-- dump date 20140619_152947 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 272631000001 SEQ_END SEQ_END NC_002677.1 3268203 3268203 DR NC_002677.1; contig end 3268203..3268203 Mycobacterium leprae TN NP_301129.1 CDS dnaA NC_002677.1 1 1566 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 1..1566 Mycobacterium leprae TN 908143 NP_301130.1 CDS dnaN NC_002677.1 2081 3280 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2081..3280 Mycobacterium leprae TN 908144 NP_301131.1 CDS recF NC_002677.1 3281 4438 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3281..4438 Mycobacterium leprae TN 910262 NP_301132.1 CDS ML0004 NC_002677.1 4435 5004 D hypothetical protein 4435..5004 Mycobacterium leprae TN 910215 NP_301133.1 CDS gyrB NC_002677.1 5229 7265 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 5229..7265 Mycobacterium leprae TN 908148 NP_301134.1 CDS gyrA NC_002677.1 7318 11067 D DNA gyrase subunit A 7318..11067 Mycobacterium leprae TN 908154 NP_301135.1 CDS ML0007 NC_002677.1 11195 12106 D hypothetical protein 11195..12106 Mycobacterium leprae TN 908160 NP_301136.1 CDS ML0008 NC_002677.1 12856 13230 R hypothetical protein complement(12856..13230) Mycobacterium leprae TN 908162 NP_301137.1 CDS ML0009 NC_002677.1 13775 13966 D hypothetical protein 13775..13966 Mycobacterium leprae TN 908165 NP_301138.1 CDS ppiA NC_002677.1 15993 16541 D peptidyl-prolyl cis-trans isomerase 15993..16541 Mycobacterium leprae TN 908167 NP_301139.1 CDS ML0012 NC_002677.1 16566 16979 R hypothetical protein complement(16566..16979) Mycobacterium leprae TN 908168 NP_301140.1 CDS ML0013 NC_002677.1 17134 17415 R integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein complement(17134..17415) Mycobacterium leprae TN 909726 NP_301141.1 CDS pabA NC_002677.1 18325 19023 D aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 18325..19023 Mycobacterium leprae TN 910411 NP_301142.1 CDS pknB NC_002677.1 19001 20869 R serine/threonine protein kinase complement(19001..20869) Mycobacterium leprae TN 908655 NP_301143.1 CDS pknA NC_002677.1 20879 22192 R serine/threonine protein kinase complement(20879..22192) Mycobacterium leprae TN 908171 NP_301144.1 CDS pbpA NC_002677.1 22189 23667 R penicillin-binding protein complement(22189..23667) Mycobacterium leprae TN 908172 NP_301145.1 CDS rodA NC_002677.1 23664 25061 R cell-division protein complement(23664..25061) Mycobacterium leprae TN 910311 NP_301146.1 CDS ML0020 NC_002677.1 25058 26587 R hypothetical protein complement(25058..26587) Mycobacterium leprae TN 908178 NP_301147.1 CDS ML0021 NC_002677.1 26584 27051 R hypothetical protein complement(26584..27051) Mycobacterium leprae TN 908179 NP_301148.1 CDS ML0022 NC_002677.1 27173 28639 R hypothetical protein complement(27173..28639) Mycobacterium leprae TN 908180 NP_301149.1 CDS ML0023 NC_002677.1 28954 29265 R hypothetical protein complement(28954..29265) Mycobacterium leprae TN 908183 NP_301150.1 CDS ML0024 NC_002677.1 29775 30026 D hypothetical protein 29775..30026 Mycobacterium leprae TN 909248 NP_301151.1 CDS ML0025 NC_002677.1 30293 30583 R hypothetical protein complement(30293..30583) Mycobacterium leprae TN 909233 NP_301152.1 CDS ML0028 NC_002677.1 33100 33705 D hypothetical protein 33100..33705 Mycobacterium leprae TN 908188 NP_301153.1 CDS ML0029 NC_002677.1 34033 34638 R hypothetical protein complement(34033..34638) Mycobacterium leprae TN 908189 NP_301154.1 CDS ML0030 NC_002677.1 34750 35091 R hypothetical protein complement(34750..35091) Mycobacterium leprae TN 908190 NP_301155.1 CDS ML0031 NC_002677.1 35287 36123 R Similar to M. tuberculosis MTC28, Rv0040c, proline rich 28 KDa antigen precursoR, SW:PR28_MYCTU (P71697) (311 aa); Fasta score E(): 0, 65.1% identity in 258 aa overlap. Previously sequenced as TR:O33075 (EMBL:Y14967) (278 aa); Fasta score E(): 0, 100.0% identity in 278 aa overlap. Contains a probable N-terminal signal sequence.; C-terminal half is similar to a region of ML0246; hypothetical protein complement(35287..36123) Mycobacterium leprae TN 908191 NP_301156.1 CDS leuS NC_002677.1 36321 39239 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 36321..39239 Mycobacterium leprae TN 908194 NP_301157.1 CDS ML0041 NC_002677.1 50656 51996 D protease 50656..51996 Mycobacterium leprae TN 908205 NP_301158.1 CDS ML0042 NC_002677.1 51993 53396 D hypothetical protein 51993..53396 Mycobacterium leprae TN 908206 NP_301159.1 CDS ML0044 NC_002677.1 54698 55039 D Similar to M. tuberculosis Rv3880c, hypothetical protein, TR:O69744 (EMBL:AL123456) (115 aa); Fasta score E(): 2.6e-21, 56.4% identity in 110 aa overlap. Previously sequenced as TR:O33080 (EMBL:Y14967) (113 aa); Fasta score E(): 0, 100.0% identity in 113 aa overlap.; hypothetical protein 54698..55039 Mycobacterium leprae TN 908209 NP_301160.1 CDS ML0047 NC_002677.1 58020 59558 R hypothetical protein complement(58020..59558) Mycobacterium leprae TN 908667 NP_301161.1 CDS ML0048 NC_002677.1 59555 61315 R hypothetical protein complement(59555..61315) Mycobacterium leprae TN 908679 NP_301162.1 CDS ML0049 NC_002677.1 61406 61693 R hypothetical protein complement(61406..61693) Mycobacterium leprae TN 908212 NP_301163.1 CDS ML0050 NC_002677.1 61720 62022 R hypothetical protein complement(61720..62022) Mycobacterium leprae TN 910497 NP_301164.1 CDS ML0051 NC_002677.1 62201 63109 R PPE family protein complement(62201..63109) Mycobacterium leprae TN 910495 NP_301165.1 CDS ML0052 NC_002677.1 63319 65112 R hypothetical protein complement(63319..65112) Mycobacterium leprae TN 910515 NP_301166.1 CDS ML0053 NC_002677.1 65186 67420 R hypothetical protein complement(65186..67420) Mycobacterium leprae TN 910139 NP_301167.1 CDS ML0054 NC_002677.1 67417 68862 R hypothetical protein complement(67417..68862) Mycobacterium leprae TN 908215 NP_301168.1 CDS ML0055 NC_002677.1 68866 70587 R hypothetical protein complement(68866..70587) Mycobacterium leprae TN 909371 NP_301169.1 CDS ML0056 NC_002677.1 70584 71093 R hypothetical protein complement(70584..71093) Mycobacterium leprae TN 909016 NP_301170.1 CDS gltB NC_002677.1 77709 82292 D ferredoxin-dependent glutamate synthase 77709..82292 Mycobacterium leprae TN 908217 NP_301171.1 CDS gltD NC_002677.1 82285 83751 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 82285..83751 Mycobacterium leprae TN 908220 NP_301172.1 CDS ML0064 NC_002677.1 85968 86612 R transcriptional regulator complement(85968..86612) Mycobacterium leprae TN 908225 NP_301173.1 CDS ML0065 NC_002677.1 86681 88165 D monooxygenase 86681..88165 Mycobacterium leprae TN 908226 NP_301174.1 CDS menG NC_002677.1 88246 88719 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(88246..88719) Mycobacterium leprae TN 908231 NP_301175.1 CDS hns NC_002677.1 88741 89106 R histone-like protein complement(88741..89106) Mycobacterium leprae TN 908182 NP_301176.1 CDS ML0068 NC_002677.1 89620 90336 R hypothetical protein complement(89620..90336) Mycobacterium leprae TN 908647 NP_301177.1 CDS ML0069 NC_002677.1 90521 90919 R hypothetical protein complement(90521..90919) Mycobacterium leprae TN 910469 NP_301178.1 CDS ML0070 NC_002677.1 91296 91559 R hypothetical protein complement(91296..91559) Mycobacterium leprae TN 910479 NP_301179.1 CDS ML0071 NC_002677.1 91913 92446 R hypothetical protein complement(91913..92446) Mycobacterium leprae TN 910383 NP_301180.1 CDS sodA NC_002677.1 92647 93270 R superoxide dismutase complement(92647..93270) Mycobacterium leprae TN 910514 NP_301181.1 CDS ML0073 NC_002677.1 94092 95126 D hypothetical protein 94092..95126 Mycobacterium leprae TN 910182 NP_301182.1 CDS glpQ NC_002677.1 95132 95947 D glycerophosphoryl diester phosphodiesterase 95132..95947 Mycobacterium leprae TN 910167 NP_301183.1 CDS pheA NC_002677.1 98425 99393 D catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 98425..99393 Mycobacterium leprae TN 910395 NP_301184.1 CDS ML0079 NC_002677.1 99390 100085 D phosphoglycerate mutase 99390..100085 Mycobacterium leprae TN 908234 NP_301185.1 CDS ML0081 NC_002677.1 100648 102000 R hypothetical protein complement(100648..102000) Mycobacterium leprae TN 908237 NP_301186.1 CDS serS NC_002677.1 102122 103375 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 102122..103375 Mycobacterium leprae TN 908238 NP_301187.1 CDS ML0087 NC_002677.1 109049 109822 D acyltransferase 109049..109822 Mycobacterium leprae TN 910442 NP_301188.1 CDS ML0089 NC_002677.1 110329 111174 D hypothetical protein 110329..111174 Mycobacterium leprae TN 908245 NP_301189.1 CDS ML0091 NC_002677.1 113153 113863 R hypothetical protein complement(113153..113863) Mycobacterium leprae TN 908705 NP_301190.1 CDS glf NC_002677.1 114130 115371 D UDP-galactopyranose mutase 114130..115371 Mycobacterium leprae TN 908271 NP_301191.1 CDS ML0093 NC_002677.1 115371 117302 D hypothetical protein 115371..117302 Mycobacterium leprae TN 908272 NP_301192.1 CDS ML0094 NC_002677.1 117295 117873 D hypothetical protein 117295..117873 Mycobacterium leprae TN 908276 NP_301193.1 CDS ML0095 NC_002677.1 117870 118778 D catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 117870..118778 Mycobacterium leprae TN 908286 NP_301194.1 CDS ML0096 NC_002677.1 118819 120768 D hypothetical protein 118819..120768 Mycobacterium leprae TN 909286 NP_301195.1 CDS fbpA NC_002677.1 121157 122149 D antigen 85A, mycolytransferase 121157..122149 Mycobacterium leprae TN 908289 NP_301196.1 CDS fbpC NC_002677.1 122310 123215 D antigen 85C, mycolyltransferase 122310..123215 Mycobacterium leprae TN 908293 NP_301197.1 CDS ML0099 NC_002677.1 123370 124380 D hypothetical protein 123370..124380 Mycobacterium leprae TN 908300 NP_301198.1 CDS fadD32 NC_002677.1 124599 126506 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 124599..126506 Mycobacterium leprae TN 908301 NP_301199.1 CDS pks13 NC_002677.1 126518 131872 D polyketide synthase 126518..131872 Mycobacterium leprae TN 908306 NP_301200.1 CDS accD4 NC_002677.1 131869 133422 D acyl CoA carboxylase [beta] subunit 131869..133422 Mycobacterium leprae TN 908326 NP_301201.1 CDS embB NC_002677.1 136573 139824 R arabinosyltransferase complement(136573..139824) Mycobacterium leprae TN 908335 NP_301202.1 CDS embA NC_002677.1 139821 143156 R arabinosyltransferase complement(139821..143156) Mycobacterium leprae TN 908337 NP_301203.1 CDS embC NC_002677.1 144115 147327 R arabinosyltransferase complement(144115..147327) Mycobacterium leprae TN 908339 NP_301204.1 CDS ML0107 NC_002677.1 147460 149358 R hypothetical protein complement(147460..149358) Mycobacterium leprae TN 908341 NP_301205.1 CDS ML0108 NC_002677.1 149361 150125 R short chain dehydrogenase complement(149361..150125) Mycobacterium leprae TN 908346 NP_301206.1 CDS ML0109 NC_002677.1 150128 151510 R FAD-linked oxidoreductase complement(150128..151510) Mycobacterium leprae TN 908350 NP_301207.1 CDS ML0110 NC_002677.1 151578 151949 R hypothetical protein complement(151578..151949) Mycobacterium leprae TN 908352 NP_301208.1 CDS ML0112 NC_002677.1 152783 153613 R ABC transporter complement(152783..153613) Mycobacterium leprae TN 908357 NP_301209.1 CDS rfbE NC_002677.1 153663 154514 R glycosyl transferase family protein complement(153663..154514) Mycobacterium leprae TN 908361 NP_301210.1 CDS ML0114 NC_002677.1 154576 155394 R ABC transporter ATP-binding protein complement(154576..155394) Mycobacterium leprae TN 908364 NP_301211.1 CDS ML0115 NC_002677.1 155413 155937 R hypothetical protein complement(155413..155937) Mycobacterium leprae TN 908366 NP_301212.1 CDS ML0116 NC_002677.1 155965 157929 R hypothetical protein complement(155965..157929) Mycobacterium leprae TN 908368 NP_301213.1 CDS ML0117 NC_002677.1 158056 159252 D hypothetical protein 158056..159252 Mycobacterium leprae TN 908375 NP_301214.1 CDS ML0118 NC_002677.1 159249 160259 R oxidireductase complement(159249..160259) Mycobacterium leprae TN 908376 NP_301215.1 CDS lipE NC_002677.1 160495 161730 R hydrolase complement(160495..161730) Mycobacterium leprae TN 908384 NP_301216.1 CDS echA1 NC_002677.1 161741 162577 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(161741..162577) Mycobacterium leprae TN 908388 NP_301217.1 CDS ML0121 NC_002677.1 163770 164039 R hypothetical protein complement(163770..164039) Mycobacterium leprae TN 908392 NP_301218.1 CDS ML0124 NC_002677.1 166949 167389 R hypothetical protein complement(166949..167389) Mycobacterium leprae TN 908405 NP_301219.1 CDS ML0125 NC_002677.1 167598 168914 D glycosyl transferase family protein 167598..168914 Mycobacterium leprae TN 908406 NP_301220.1 CDS ML0126 NC_002677.1 169585 170406 D hypothetical protein 169585..170406 Mycobacterium leprae TN 908419 NP_301221.1 CDS ML0127 NC_002677.1 170662 171351 D hypothetical protein 170662..171351 Mycobacterium leprae TN 908423 NP_301222.1 CDS ML0128 NC_002677.1 171616 172923 D glycosyl transferase family protein 171616..172923 Mycobacterium leprae TN 908425 NP_301223.1 CDS ML0129 NC_002677.1 173170 174426 R hypothetical protein complement(173170..174426) Mycobacterium leprae TN 908431 NP_301224.1 CDS ML0130 NC_002677.1 174466 175278 R hypothetical protein complement(174466..175278) Mycobacterium leprae TN 908432 NP_301225.1 CDS ML0131 NC_002677.1 175441 176589 D oxidoreductase 175441..176589 Mycobacterium leprae TN 908434 NP_301226.2 CDS fadD29 NC_002677.1 177464 179212 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 177464..179212 Mycobacterium leprae TN 908436 NP_301227.1 CDS ML0133 NC_002677.1 179256 179888 D hypothetical protein 179256..179888 Mycobacterium leprae TN 908439 NP_301228.1 CDS fadD22 NC_002677.1 180027 182150 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 180027..182150 Mycobacterium leprae TN 908446 NP_301229.1 CDS ML0135 NC_002677.1 182173 188484 D polyketide synthase 182173..188484 Mycobacterium leprae TN 908453 NP_301230.1 CDS lppX NC_002677.1 188551 189252 D lipoprotein 188551..189252 Mycobacterium leprae TN 908464 NP_301231.1 CDS mmpL7 NC_002677.1 189253 191961 R hypothetical protein complement(189253..191961) Mycobacterium leprae TN 908466 NP_301232.1 CDS fadD28 NC_002677.1 192013 193752 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(192013..193752) Mycobacterium leprae TN 908470 NP_301233.1 CDS mas NC_002677.1 194221 200571 D mycocerosic synthase 194221..200571 Mycobacterium leprae TN 908474 NP_301234.1 CDS ML0141 NC_002677.1 202307 202561 R hypothetical protein complement(202307..202561) Mycobacterium leprae TN 908482 NP_301235.1 CDS ML0142 NC_002677.1 204363 204611 D hypothetical protein 204363..204611 Mycobacterium leprae TN 908486 NP_301236.1 CDS pgi NC_002677.1 211150 212814 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(211150..212814) Mycobacterium leprae TN 908501 NP_301237.1 CDS ML0151 NC_002677.1 213175 213492 R hypothetical protein complement(213175..213492) Mycobacterium leprae TN 908503 NP_301238.1 CDS ML0152 NC_002677.1 214001 214189 D hypothetical protein 214001..214189 Mycobacterium leprae TN 908504 NP_301239.1 CDS uvrD NC_002677.1 214272 216608 D ATP-dependent DNA helicase 214272..216608 Mycobacterium leprae TN 908505 NP_301240.1 CDS ML0154 NC_002677.1 217160 218161 R hypothetical protein complement(217160..218161) Mycobacterium leprae TN 908508 NP_301241.1 CDS sucC NC_002677.1 218458 219639 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 218458..219639 Mycobacterium leprae TN 908509 NP_301242.1 CDS sucD NC_002677.1 219659 220561 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 219659..220561 Mycobacterium leprae TN 908514 NP_301243.1 CDS ML0158 NC_002677.1 221657 222601 D hypothetical protein 221657..222601 Mycobacterium leprae TN 908522 NP_301244.1 CDS ML0159 NC_002677.1 222650 223942 D hypothetical protein 222650..223942 Mycobacterium leprae TN 908525 NP_301245.1 CDS purN NC_002677.1 223972 224619 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 223972..224619 Mycobacterium leprae TN 908527 NP_301246.1 CDS purH NC_002677.1 224616 226199 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 224616..226199 Mycobacterium leprae TN 908529 NP_301247.1 CDS ML0162 NC_002677.1 227008 227286 R hypothetical protein complement(227008..227286) Mycobacterium leprae TN 908533 NP_301248.1 CDS ML0169 NC_002677.1 234932 235534 D hypothetical protein 234932..235534 Mycobacterium leprae TN 908537 NP_301249.1 CDS rpmF NC_002677.1 240237 240410 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 240237..240410 Mycobacterium leprae TN 908550 NP_301250.1 CDS ML0174 NC_002677.1 240531 241217 D two-component response regulator 240531..241217 Mycobacterium leprae TN 908551 NP_301251.1 CDS ML0175 NC_002677.1 241217 242776 D two-component system sensor kinase 241217..242776 Mycobacterium leprae TN 908554 NP_301252.1 CDS ML0176 NC_002677.1 243054 244202 D serine protease 243054..244202 Mycobacterium leprae TN 908555 NP_301253.1 CDS moaB NC_002677.1 244225 244770 D molybdenum cofactor biosynthesis protein 244225..244770 Mycobacterium leprae TN 908557 NP_301254.1 CDS mscL NC_002677.1 244787 245251 R forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel complement(244787..245251) Mycobacterium leprae TN 908560 NP_301255.1 CDS ML0180 NC_002677.1 246049 246348 R hypothetical protein complement(246049..246348) Mycobacterium leprae TN 908562 NP_301256.1 CDS ML0181 NC_002677.1 246423 247016 R hypothetical protein complement(246423..247016) Mycobacterium leprae TN 908563 NP_301257.1 CDS galU NC_002677.1 247094 248014 D UTP-glucose-1-phosphate uridylyltransferase 247094..248014 Mycobacterium leprae TN 908564 NP_301258.1 CDS moeA NC_002677.1 248102 249376 D molybdopterin biosynthesis protein 248102..249376 Mycobacterium leprae TN 908566 NP_301259.1 CDS rimJ NC_002677.1 249407 250051 D acetyltransferase 249407..250051 Mycobacterium leprae TN 908570 NP_301260.1 CDS ML0185 NC_002677.1 250221 251249 D hypothetical protein 250221..251249 Mycobacterium leprae TN 908571 NP_301261.1 CDS ML0187 NC_002677.1 252658 253719 D hypothetical protein 252658..253719 Mycobacterium leprae TN 908577 NP_301262.1 CDS ML0188 NC_002677.1 254028 254291 D hypothetical protein 254028..254291 Mycobacterium leprae TN 908579 NP_301263.1 CDS ML0190 NC_002677.1 255125 255742 R hypothetical protein complement(255125..255742) Mycobacterium leprae TN 908584 NP_301264.1 CDS ML0192 NC_002677.1 257035 258567 R hypothetical protein complement(257035..258567) Mycobacterium leprae TN 908586 NP_301265.1 CDS ML0193 NC_002677.1 258646 259491 D hypothetical protein 258646..259491 Mycobacterium leprae TN 908587 NP_301266.1 CDS cspA NC_002677.1 264898 265101 D cold shock protein 264898..265101 Mycobacterium leprae TN 908596 NP_301267.1 CDS ML0199 NC_002677.1 265213 265815 D Similar to M. tuberculosis Rv3647c, hypothetical protein, TR:O06361 (EMBL:AL123456) (192 aa); Fasta score E(): 0, 80.4% identity in 199 aa overlap. Previously sequenced as TR:O69549 (EMBL:AL023093) (200 aa); Fasta score E(): 0, 99.5% identity in 200 aa overlap.; hypothetical protein 265213..265815 Mycobacterium leprae TN 908598 NP_301268.1 CDS topA NC_002677.1 266033 268876 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 266033..268876 Mycobacterium leprae TN 908599 NP_301269.1 CDS ML0201 NC_002677.1 268857 270449 R hypothetical protein complement(268857..270449) Mycobacterium leprae TN 908603 NP_301270.1 CDS ML0202 NC_002677.1 270605 271822 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 270605..271822 Mycobacterium leprae TN 908611 NP_301271.1 CDS ML0203 NC_002677.1 273290 274999 R hypothetical protein complement(273290..274999) Mycobacterium leprae TN 908612 NP_301272.1 CDS rmlB2 NC_002677.1 275049 276008 D sugar-nucleotide dehydratase 275049..276008 Mycobacterium leprae TN 908608 NP_301273.1 CDS ML0205 NC_002677.1 276707 277777 R hypothetical protein complement(276707..277777) Mycobacterium leprae TN 909886 NP_301274.1 CDS ML0207 NC_002677.1 279051 279770 D glycosyltransferase 279051..279770 Mycobacterium leprae TN 908618 NP_301275.1 CDS ML0208 NC_002677.1 279784 280125 D hypothetical protein 279784..280125 Mycobacterium leprae TN 908621 NP_301276.1 CDS ppa NC_002677.1 281543 282031 R catalyzes the hydrolysis of pyrophosphate; inorganic pyrophosphatase complement(281543..282031) Mycobacterium leprae TN 908623 NP_301277.1 CDS ML0211 NC_002677.1 282157 283542 D carboxypeptidase 282157..283542 Mycobacterium leprae TN 909586 NP_301278.1 CDS mesJ NC_002677.1 284580 285551 D hypothetical protein 284580..285551 Mycobacterium leprae TN 909579 NP_301279.1 CDS hpt NC_002677.1 285584 286225 D Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 285584..286225 Mycobacterium leprae TN 909576 NP_301280.1 CDS ML0217 NC_002677.1 288678 288923 D hypothetical protein 288678..288923 Mycobacterium leprae TN 908629 NP_301281.1 CDS ML0218 NC_002677.1 289829 290215 R hypothetical protein complement(289829..290215) Mycobacterium leprae TN 908630 NP_301282.1 CDS ftsH NC_002677.1 293693 296065 D integral membrane peptidase 293693..296065 Mycobacterium leprae TN 908637 NP_301283.1 CDS folE NC_002677.1 296082 296699 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 296082..296699 Mycobacterium leprae TN 909895 NP_301284.1 CDS folP NC_002677.1 296696 297550 D dihydropteroate synthase 296696..297550 Mycobacterium leprae TN 908646 NP_301285.1 CDS folB NC_002677.1 297543 297941 D dihydroneopterin aldolase 297543..297941 Mycobacterium leprae TN 908411 NP_301286.1 CDS folK NC_002677.1 297941 298516 D 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 297941..298516 Mycobacterium leprae TN 908689 NP_301287.1 CDS ML0227 NC_002677.1 298516 298992 D hypothetical protein 298516..298992 Mycobacterium leprae TN 908697 NP_301288.1 CDS ML0228 NC_002677.1 299138 300436 D hypothetical protein 299138..300436 Mycobacterium leprae TN 908664 NP_301289.1 CDS ML0229 NC_002677.1 300537 301466 D hypothetical protein 300537..301466 Mycobacterium leprae TN 908662 NP_301290.1 CDS panC NC_002677.1 301463 302404 D catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 301463..302404 Mycobacterium leprae TN 908653 NP_301291.1 CDS panD NC_002677.1 302404 302832 D Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 302404..302832 Mycobacterium leprae TN 908678 NP_301292.1 CDS ML0232 NC_002677.1 302835 303659 D type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 302835..303659 Mycobacterium leprae TN 908665 NP_301293.1 CDS lysS NC_002677.1 303740 305263 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 303740..305263 Mycobacterium leprae TN 908650 NP_301294.1 CDS lsr2 NC_002677.1 305368 305706 D lsr2 protein (15 kDa antigen) 305368..305706 Mycobacterium leprae TN 909223 NP_301295.1 CDS clpC NC_002677.1 306003 308549 D ATP-dependent Clp protease 306003..308549 Mycobacterium leprae TN 908260 NP_301296.1 CDS pabB NC_002677.1 309643 310899 R catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I complement(309643..310899) Mycobacterium leprae TN 908703 NP_301297.1 CDS metG NC_002677.1 312208 313821 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(312208..313821) Mycobacterium leprae TN 908704 NP_301298.1 CDS ML0239 NC_002677.1 313910 314698 D hypothetical protein 313910..314698 Mycobacterium leprae TN 908709 NP_301299.1 CDS ML0240 NC_002677.1 314948 316075 D hypothetical protein 314948..316075 Mycobacterium leprae TN 908712 NP_301300.1 CDS ksgA NC_002677.1 316048 316968 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 316048..316968 Mycobacterium leprae TN 908714 NP_301301.1 CDS ML0242 NC_002677.1 317042 317977 D catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 317042..317977 Mycobacterium leprae TN 908715 NP_301302.1 CDS ML0243 NC_002677.1 318220 319854 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 318220..319854 Mycobacterium leprae TN 908719 NP_301303.1 CDS pth NC_002677.1 319965 320564 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(319965..320564) Mycobacterium leprae TN 908725 NP_301304.1 CDS rplY NC_002677.1 320577 321224 R the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 complement(320577..321224) Mycobacterium leprae TN 908726 NP_301305.1 CDS lpqT NC_002677.1 322399 323055 R lipoprotein complement(322399..323055) Mycobacterium leprae TN 908727 NP_301306.1 CDS arsC NC_002677.1 323092 323406 R arsenate reductase complement(323092..323406) Mycobacterium leprae TN 908728 NP_301307.1 CDS prsA NC_002677.1 323462 324445 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(323462..324445) Mycobacterium leprae TN 908729 NP_301308.1 CDS glmU NC_002677.1 324556 326034 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(324556..326034) Mycobacterium leprae TN 908736 NP_301309.1 CDS mfd NC_002677.1 328067 331741 D transcription-repair coupling factor 328067..331741 Mycobacterium leprae TN 908750 NP_301310.1 CDS eno NC_002677.1 333751 335094 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 333751..335094 Mycobacterium leprae TN 908757 NP_301311.1 CDS ML0256 NC_002677.1 335129 335812 D hypothetical protein 335129..335812 Mycobacterium leprae TN 908762 NP_301312.1 CDS ML0257 NC_002677.1 335805 336308 D hypothetical protein 335805..336308 Mycobacterium leprae TN 908763 NP_301313.1 CDS ML0258 NC_002677.1 336305 337258 D hypothetical protein 336305..337258 Mycobacterium leprae TN 909924 NP_301314.1 CDS ML0265 NC_002677.1 345708 345920 D hypothetical protein 345708..345920 Mycobacterium leprae TN 908772 NP_301315.1 CDS ML0269 NC_002677.1 353007 354017 R F420-dependent glucose-6-phosphate dehydrogenase complement(353007..354017) Mycobacterium leprae TN 908785 NP_301316.1 CDS ML0270 NC_002677.1 354105 354860 D hypothetical protein 354105..354860 Mycobacterium leprae TN 908790 NP_301317.1 CDS ML0271 NC_002677.1 354849 355220 R hypothetical protein complement(354849..355220) Mycobacterium leprae TN 908793 NP_301318.1 CDS metZ NC_002677.1 357557 358777 R O-succinylhomoserine sulfhydrylase complement(357557..358777) Mycobacterium leprae TN 908802 NP_301319.1 CDS ML0276 NC_002677.1 358834 359277 R hypothetical protein complement(358834..359277) Mycobacterium leprae TN 908803 NP_301320.1 CDS ML0279 NC_002677.1 361297 361953 R hypothetical protein complement(361297..361953) Mycobacterium leprae TN 908814 NP_301321.1 CDS purA NC_002677.1 361950 363248 R catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase complement(361950..363248) Mycobacterium leprae TN 908815 NP_301322.1 CDS ML0281 NC_002677.1 363432 364121 D hypothetical protein 363432..364121 Mycobacterium leprae TN 908819 NP_301323.1 CDS ML0283 NC_002677.1 364916 365722 D cation-efflux transporter component 364916..365722 Mycobacterium leprae TN 909352 NP_301324.1 CDS ML0284 NC_002677.1 365860 366273 R hypothetical protein complement(365860..366273) Mycobacterium leprae TN 908258 NP_301325.1 CDS ML0285 NC_002677.1 366385 367263 D hypothetical protein 366385..367263 Mycobacterium leprae TN 908823 NP_301326.1 CDS fba NC_002677.1 367279 368316 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(367279..368316) Mycobacterium leprae TN 908824 NP_301327.1 CDS ML0287 NC_002677.1 368449 369117 D hypothetical protein 368449..369117 Mycobacterium leprae TN 908826 NP_301328.1 CDS ML0291 NC_002677.1 372034 372426 R hypothetical protein complement(372034..372426) Mycobacterium leprae TN 908832 NP_301329.1 CDS ML0292 NC_002677.1 373605 373844 R hypothetical protein complement(373605..373844) Mycobacterium leprae TN 908838 NP_301330.1 CDS ML0293 NC_002677.1 375453 375662 R hypothetical protein complement(375453..375662) Mycobacterium leprae TN 908839 NP_301331.1 CDS thiC NC_002677.1 377487 379130 D required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 377487..379130 Mycobacterium leprae TN 908846 NP_301332.1 CDS thiD NC_002677.1 379127 379966 D catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 379127..379966 Mycobacterium leprae TN 908848 NP_301333.1 CDS thiG NC_002677.1 380645 381430 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(380645..381430) Mycobacterium leprae TN 908850 NP_301334.1 CDS ML0298 NC_002677.1 381423 381647 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(381423..381647) Mycobacterium leprae TN 908851 NP_301335.1 CDS ML0299 NC_002677.1 381655 382677 R oxidoreductase complement(381655..382677) Mycobacterium leprae TN 908853 NP_301336.1 CDS thiE NC_002677.1 382835 383542 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 382835..383542 Mycobacterium leprae TN 908861 NP_301337.1 CDS glnH NC_002677.1 385649 386629 D glutamine-binding protein 385649..386629 Mycobacterium leprae TN 908869 NP_301338.1 CDS pknG NC_002677.1 386629 388932 D serine-threonine protein kinase 386629..388932 Mycobacterium leprae TN 908881 NP_301339.1 CDS ML0308 NC_002677.1 394457 395161 D hypothetical protein 394457..395161 Mycobacterium leprae TN 908883 NP_301340.1 CDS pssA NC_002677.1 397046 397948 R CDP-diacylglycerol-serine o-phosphatidyltransferase complement(397046..397948) Mycobacterium leprae TN 909217 NP_301341.1 CDS ML0311 NC_002677.1 397945 398676 R catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase complement(397945..398676) Mycobacterium leprae TN 908894 NP_301342.1 CDS ML0314 NC_002677.1 400771 401778 R esterase complement(400771..401778) Mycobacterium leprae TN 908895 NP_301343.1 CDS ML0315 NC_002677.1 403698 404612 R short chain dehydrogenase complement(403698..404612) Mycobacterium leprae TN 908901 NP_301344.1 CDS ML0316 NC_002677.1 404707 405309 D TetR/AcrR family transcriptional regulator 404707..405309 Mycobacterium leprae TN 908902 NP_301345.1 CDS groEL NC_002677.1 405518 407143 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 405518..407143 Mycobacterium leprae TN 908906 NP_301346.1 CDS lpqE NC_002677.1 409442 409993 R lipoprotein complement(409442..409993) Mycobacterium leprae TN 909986 NP_301347.1 CDS ML0320 NC_002677.1 410354 410851 D transcription factor 410354..410851 Mycobacterium leprae TN 908908 NP_301348.1 CDS ispD NC_002677.1 410870 411595 D 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 410870..411595 Mycobacterium leprae TN 908913 NP_301349.1 CDS ispF NC_002677.1 411592 412068 D catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 411592..412068 Mycobacterium leprae TN 908920 NP_301350.1 CDS cysS NC_002677.1 412123 413544 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 412123..413544 Mycobacterium leprae TN 908923 NP_301351.1 CDS ML0324 NC_002677.1 413627 414463 D methyltransferase 413627..414463 Mycobacterium leprae TN 908924 NP_301352.1 CDS ML0325 NC_002677.1 414865 415128 D hypothetical protein 414865..415128 Mycobacterium leprae TN 908919 NP_301353.1 CDS ML0333 NC_002677.1 423178 423936 R LamB/YcsF family protein complement(423178..423936) Mycobacterium leprae TN 908943 NP_301354.1 CDS ML0335 NC_002677.1 424867 425727 R ABC-transporter transmembrane protein complement(424867..425727) Mycobacterium leprae TN 908949 NP_301355.1 CDS ML0336 NC_002677.1 425727 426554 R ABC-transporter ATP-binding protein complement(425727..426554) Mycobacterium leprae TN 908873 NP_301356.1 CDS ML0337 NC_002677.1 426563 427471 R periplasmic solute-binding proteins complement(426563..427471) Mycobacterium leprae TN 908929 NP_301357.1 CDS ML0348 NC_002677.1 438262 439314 D coenzyme F420-dependent oxidoreductase 438262..439314 Mycobacterium leprae TN 908969 NP_301358.1 CDS ilvX NC_002677.1 447414 448961 D thiamine-pyrophosphate requiring enzyme; hypothetical protein 447414..448961 Mycobacterium leprae TN 908997 NP_301359.1 CDS ML0363 NC_002677.1 456418 456732 D hypothetical protein 456418..456732 Mycobacterium leprae TN 909015 NP_301360.1 CDS rplM NC_002677.1 456984 457427 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 456984..457427 Mycobacterium leprae TN 909021 NP_301361.1 CDS rpsI NC_002677.1 457424 457885 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 457424..457885 Mycobacterium leprae TN 909023 NP_301362.1 CDS glmM NC_002677.1 457992 459383 D catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 457992..459383 Mycobacterium leprae TN 909025 NP_301363.1 CDS ML0369 NC_002677.1 461185 461541 R hypothetical protein complement(461185..461541) Mycobacterium leprae TN 909042 NP_301364.1 CDS ML0370 NC_002677.1 461945 462814 R hypothetical protein complement(461945..462814) Mycobacterium leprae TN 909043 NP_301365.1 CDS glmS NC_002677.1 462979 464856 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 462979..464856 Mycobacterium leprae TN 909050 NP_301366.1 CDS ML0373 NC_002677.1 465202 466623 D hypothetical protein 465202..466623 Mycobacterium leprae TN 909029 NP_301367.1 CDS alr NC_002677.1 468132 469298 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 468132..469298 Mycobacterium leprae TN 909060 NP_301368.1 CDS ML0376 NC_002677.1 469288 470289 D hypothetical protein 469288..470289 Mycobacterium leprae TN 909058 NP_301369.1 CDS ML0377 NC_002677.1 470282 470767 D Similar to M. tuberculosis Rv3422c, conserved hypothetical protein, SW:YY22_MYCTU (Q50706) (168 aa); Fasta score E(): 0, 77.4% identity in 146 aa overlap. Similar to many other bacterial hypothetical proteins. Previously sequenced as SW:YY22_MYCLE (Q49864) (161 aa); Fasta score E(): 0, 100.0% identity in 161 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein 470282..470767 Mycobacterium leprae TN 909051 NP_301370.1 CDS ML0378 NC_002677.1 470764 471843 D acetyltransferase 470764..471843 Mycobacterium leprae TN 909063 NP_301371.1 CDS gcp NC_002677.1 471840 472895 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 471840..472895 Mycobacterium leprae TN 909071 NP_301372.1 CDS groES NC_002677.1 473177 473479 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 473177..473479 Mycobacterium leprae TN 909076 NP_301373.1 CDS groEL NC_002677.1 473558 475171 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; molecular chaperone GroEL 473558..475171 Mycobacterium leprae TN 909064 NP_301374.1 CDS whiB3 NC_002677.1 475771 476079 R transcriptional regulator complement(475771..476079) Mycobacterium leprae TN 909062 NP_301375.1 CDS ML0383 NC_002677.1 476440 477285 D hypothetical protein 476440..477285 Mycobacterium leprae TN 909081 NP_301376.1 CDS ML0386 NC_002677.1 480093 480506 R hypothetical protein complement(480093..480506) Mycobacterium leprae TN 909089 NP_301377.1 CDS guaB2 NC_002677.1 480661 482250 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 480661..482250 Mycobacterium leprae TN 909092 NP_301378.1 CDS guaB3 NC_002677.1 482274 483386 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 482274..483386 Mycobacterium leprae TN 909090 NP_301379.1 CDS choD NC_002677.1 483451 485160 D cholesterol oxidase 483451..485160 Mycobacterium leprae TN 909085 NP_301380.1 CDS ML0392 NC_002677.1 486263 488641 R sugar phosphorylase complement(486263..488641) Mycobacterium leprae TN 909082 NP_301381.1 CDS ML0393 NC_002677.1 488655 489440 R hydrolase complement(488655..489440) Mycobacterium leprae TN 909103 NP_301382.1 CDS ML0394 NC_002677.1 489915 490427 R hypothetical protein complement(489915..490427) Mycobacterium leprae TN 909105 NP_301383.1 CDS guaA NC_002677.1 491043 492632 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 491043..492632 Mycobacterium leprae TN 909317 NP_301384.1 CDS ML0396 NC_002677.1 492714 493823 R hypothetical protein complement(492714..493823) Mycobacterium leprae TN 909120 NP_301385.1 CDS ML0397 NC_002677.1 493939 495747 R transporter protein complement(493939..495747) Mycobacterium leprae TN 909124 NP_301386.1 CDS ML0398 NC_002677.1 496060 497097 R D-ribose-binding protein complement(496060..497097) Mycobacterium leprae TN 909148 NP_301387.1 CDS ML0405 NC_002677.1 503217 504401 D hypothetical protein 503217..504401 Mycobacterium leprae TN 909138 NP_301388.1 CDS ML0406 NC_002677.1 504459 504779 D hypothetical protein 504459..504779 Mycobacterium leprae TN 909142 NP_301389.1 CDS ML0407 NC_002677.1 504793 505443 D hypothetical protein 504793..505443 Mycobacterium leprae TN 909144 NP_301390.1 CDS ML0410 NC_002677.1 508327 508629 D PE-family protein 508327..508629 Mycobacterium leprae TN 909139 NP_301391.1 CDS ML0411 NC_002677.1 508755 509981 D serine-rich protein 508755..509981 Mycobacterium leprae TN 909149 NP_301392.1 CDS otsB2 NC_002677.1 511984 513273 R trehalose-6-phosphate phosphatase complement(511984..513273) Mycobacterium leprae TN 909153 NP_301393.1 CDS ML0418 NC_002677.1 517644 518276 D oxidoreductase 517644..518276 Mycobacterium leprae TN 909158 NP_301394.1 CDS ML0419 NC_002677.1 518414 518890 R tRNA/rRNA methyltransferase complement(518414..518890) Mycobacterium leprae TN 909160 NP_301395.1 CDS bcp NC_002677.1 523803 524288 R antioxidant protein complement(523803..524288) Mycobacterium leprae TN 909166 NP_301396.1 CDS ML0425 NC_002677.1 524416 524643 D hypothetical protein 524416..524643 Mycobacterium leprae TN 909167 NP_301397.1 CDS lppS NC_002677.1 524929 526143 D hypothetical protein 524929..526143 Mycobacterium leprae TN 909169 NP_301398.1 CDS ML0427 NC_002677.1 526294 526941 R 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease complement(526294..526941) Mycobacterium leprae TN 909171 NP_301399.1 CDS ML0429 NC_002677.1 528621 529427 R oxidoreductase complement(528621..529427) Mycobacterium leprae TN 909173 NP_301400.1 CDS ML0430 NC_002677.1 529520 530884 D hypothetical protein 529520..530884 Mycobacterium leprae TN 909156 NP_301401.1 CDS ML0431 NC_002677.1 530916 531695 R hypothetical protein complement(530916..531695) Mycobacterium leprae TN 909174 NP_301402.1 CDS ML0447 NC_002677.1 547312 547788 D hypothetical protein 547312..547788 Mycobacterium leprae TN 909194 NP_301403.1 CDS ML0448 NC_002677.1 547992 548264 D hypothetical protein 547992..548264 Mycobacterium leprae TN 909195 NP_301404.1 CDS ML0450 NC_002677.1 550193 551116 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(550193..551116) Mycobacterium leprae TN 909197 NP_301405.1 CDS ML0451 NC_002677.1 551191 552240 R hypothetical protein complement(551191..552240) Mycobacterium leprae TN 909198 NP_301406.1 CDS ML0452 NC_002677.1 552240 553364 R glycosyltransferase complement(552240..553364) Mycobacterium leprae TN 909199 NP_301407.1 CDS ML0453 NC_002677.1 553374 554336 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(553374..554336) Mycobacterium leprae TN 909200 NP_301408.1 CDS pgsA NC_002677.1 554333 555052 R phosphatidyltransferase complement(554333..555052) Mycobacterium leprae TN 909202 NP_301409.1 CDS ML0455 NC_002677.1 555049 555669 R hypothetical protein complement(555049..555669) Mycobacterium leprae TN 909203 NP_301410.1 CDS thrS NC_002677.1 555662 557770 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(555662..557770) Mycobacterium leprae TN 909205 NP_301411.1 CDS ML0458 NC_002677.1 558363 559268 R oxidoreductase complement(558363..559268) Mycobacterium leprae TN 909365 NP_301412.1 CDS ML0464 NC_002677.1 561808 562095 D hypothetical protein 561808..562095 Mycobacterium leprae TN 909188 NP_301413.1 CDS ML0466 NC_002677.1 563632 564537 D hypothetical protein 563632..564537 Mycobacterium leprae TN 909212 NP_301414.1 CDS dedA NC_002677.1 564583 565227 D hypothetical protein 564583..565227 Mycobacterium leprae TN 909213 NP_301415.1 CDS ML0468 NC_002677.1 566057 566839 R hypothetical protein complement(566057..566839) Mycobacterium leprae TN 909214 NP_301416.1 CDS ML0470 NC_002677.1 571603 571893 R hypothetical protein complement(571603..571893) Mycobacterium leprae TN 909216 NP_301417.1 CDS ML0472 NC_002677.1 574032 574274 D hypothetical protein 574032..574274 Mycobacterium leprae TN 909219 NP_301418.1 CDS ML0473 NC_002677.1 574538 574810 D hypothetical protein 574538..574810 Mycobacterium leprae TN 909220 NP_301419.2 CDS ML0474 NC_002677.1 575544 576140 D with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 575544..576140 Mycobacterium leprae TN 909221 NP_301420.1 CDS ML0475 NC_002677.1 576361 577116 D hypothetical protein 576361..577116 Mycobacterium leprae TN 909222 NP_301421.1 CDS ruvC NC_002677.1 581224 581790 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 581224..581790 Mycobacterium leprae TN 909230 NP_301422.1 CDS ruvA NC_002677.1 581787 582398 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 581787..582398 Mycobacterium leprae TN 909231 NP_301423.1 CDS ruvB NC_002677.1 582395 583444 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 582395..583444 Mycobacterium leprae TN 909232 NP_301424.1 CDS fadD9 NC_002677.1 584381 587947 R acyl-CoA synthetase complement(584381..587947) Mycobacterium leprae TN 909234 NP_301425.1 CDS gabT NC_002677.1 588043 589383 R catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase complement(588043..589383) Mycobacterium leprae TN 909237 NP_301426.1 CDS yajC NC_002677.1 589652 589996 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 589652..589996 Mycobacterium leprae TN 909239 NP_301427.2 CDS secD NC_002677.1 590114 591829 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 590114..591829 Mycobacterium leprae TN 909240 NP_301428.1 CDS secF NC_002677.1 591834 593249 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 591834..593249 Mycobacterium leprae TN 909241 NP_301429.1 CDS ML0489 NC_002677.1 593294 594961 D lipoprotein 593294..594961 Mycobacterium leprae TN 909242 NP_301430.1 CDS relA NC_002677.1 595607 597970 D GTP pyrophosphokinase 595607..597970 Mycobacterium leprae TN 909244 NP_301431.1 CDS ppiB NC_002677.1 598029 598916 R peptidyl-prolyl cis-trans isomerase complement(598029..598916) Mycobacterium leprae TN 909245 NP_301432.1 CDS ML0493 NC_002677.1 599080 599736 D hydrolase 599080..599736 Mycobacterium leprae TN 909236 NP_301433.1 CDS hisS NC_002677.1 599740 601023 D catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 599740..601023 Mycobacterium leprae TN 909246 NP_301434.1 CDS aspS NC_002677.1 606839 608608 D catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 606839..608608 Mycobacterium leprae TN 909256 NP_301435.1 CDS ML0508 NC_002677.1 617501 618442 D hypothetical protein 617501..618442 Mycobacterium leprae TN 909264 NP_301436.1 CDS ML0510 NC_002677.1 619666 621087 D recombination factor protein RarA 619666..621087 Mycobacterium leprae TN 909266 NP_301437.1 CDS alaS NC_002677.1 622159 624885 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 622159..624885 Mycobacterium leprae TN 909268 NP_301438.1 CDS ML0513 NC_002677.1 624886 625440 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 624886..625440 Mycobacterium leprae TN 909269 NP_301439.1 CDS ML0514 NC_002677.1 625433 626698 D hypothetical protein 625433..626698 Mycobacterium leprae TN 909271 NP_301440.1 CDS aroE NC_002677.1 626676 627512 D AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 626676..627512 Mycobacterium leprae TN 909272 NP_301441.1 CDS aroF NC_002677.1 627741 628964 D catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 627741..628964 Mycobacterium leprae TN 909273 NP_301442.1 CDS aroK NC_002677.1 628972 629571 D catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 628972..629571 Mycobacterium leprae TN 909274 NP_301443.1 CDS aroB NC_002677.1 629568 630653 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 629568..630653 Mycobacterium leprae TN 909275 NP_301444.1 CDS aroD NC_002677.1 630653 631090 D catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 630653..631090 Mycobacterium leprae TN 909276 NP_301445.1 CDS ML0520 NC_002677.1 631179 631787 R hypothetical protein complement(631179..631787) Mycobacterium leprae TN 909277 NP_301446.1 CDS pepQ NC_002677.1 631821 632951 D peptidase 631821..632951 Mycobacterium leprae TN 909278 NP_301447.1 CDS efp NC_002677.1 632967 633530 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 632967..633530 Mycobacterium leprae TN 909281 NP_301448.1 CDS nusB NC_002677.1 633533 634105 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 633533..634105 Mycobacterium leprae TN 909283 NP_301449.1 CDS adi NC_002677.1 634643 637495 D amino acid decarboxylase 634643..637495 Mycobacterium leprae TN 909285 NP_301450.1 CDS ML0525 NC_002677.1 637492 637668 D hypothetical protein 637492..637668 Mycobacterium leprae TN 909288 NP_301451.1 CDS ML0527 NC_002677.1 639678 639932 R hypothetical protein complement(639678..639932) Mycobacterium leprae TN 909290 NP_301452.1 CDS pyrB NC_002677.1 645581 646546 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 645581..646546 Mycobacterium leprae TN 908253 NP_301453.1 CDS pyrC NC_002677.1 646543 647835 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 646543..647835 Mycobacterium leprae TN 909295 NP_301454.1 CDS carA NC_002677.1 648422 649549 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 648422..649549 Mycobacterium leprae TN 909297 NP_301455.2 CDS carB NC_002677.1 649632 652997 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 649632..652997 Mycobacterium leprae TN 909300 NP_301456.1 CDS pyrF NC_002677.1 652994 653842 D OMP decarboxylase; OMPDCase; OMPdecase; type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 652994..653842 Mycobacterium leprae TN 909117 NP_301457.1 CDS PE NC_002677.1 654129 654437 D PE-family protein 654129..654437 Mycobacterium leprae TN 909302 NP_301458.1 CDS PPE NC_002677.1 654434 656050 D PPE family protein 654434..656050 Mycobacterium leprae TN 909303 NP_301459.1 CDS mihF NC_002677.1 656895 657212 D integration host factor 656895..657212 Mycobacterium leprae TN 909305 NP_301460.1 CDS gmk NC_002677.1 657266 657898 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 657266..657898 Mycobacterium leprae TN 909307 NP_301461.1 CDS ML0542 NC_002677.1 657980 658312 D Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 657980..658312 Mycobacterium leprae TN 909310 NP_301462.1 CDS dfp NC_002677.1 658333 659592 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 658333..659592 Mycobacterium leprae TN 909311 NP_301463.1 CDS metK NC_002677.1 659721 660932 D methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 659721..660932 Mycobacterium leprae TN 909312 NP_301464.1 CDS priA NC_002677.1 664260 666215 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 664260..666215 Mycobacterium leprae TN 909319 NP_301465.1 CDS ML0550 NC_002677.1 667331 667816 D MarR family transcriptional regulator 667331..667816 Mycobacterium leprae TN 909322 NP_301466.1 CDS ML0551 NC_002677.1 667998 668822 R methyltransferase complement(667998..668822) Mycobacterium leprae TN 909323 NP_301467.1 CDS fmt NC_002677.1 669003 669959 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 669003..669959 Mycobacterium leprae TN 909326 NP_301468.1 CDS rpe NC_002677.1 671416 672090 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 671416..672090 Mycobacterium leprae TN 909330 NP_301469.1 CDS ribG NC_002677.1 672087 673106 D bifunctional riboflavin-specific deaminase/reductase 672087..673106 Mycobacterium leprae TN 909332 NP_301470.1 CDS ML0556 NC_002677.1 673150 674679 R integral membrane drug transport protein complement(673150..674679) Mycobacterium leprae TN 909333 NP_301471.1 CDS lprG NC_002677.1 674679 675395 R lipoprotein complement(674679..675395) Mycobacterium leprae TN 909335 NP_301472.1 CDS ribC NC_002677.1 675552 676175 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 675552..676175 Mycobacterium leprae TN 909336 NP_301473.1 CDS ribA NC_002677.1 676302 677609 D bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 676302..677609 Mycobacterium leprae TN 909338 NP_301474.1 CDS ribH NC_002677.1 677606 678088 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 677606..678088 Mycobacterium leprae TN 909339 NP_301475.1 CDS ML0561 NC_002677.1 678085 678555 D hypothetical protein 678085..678555 Mycobacterium leprae TN 909342 NP_301476.1 CDS uvrC NC_002677.1 678870 680813 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 678870..680813 Mycobacterium leprae TN 909343 NP_301477.1 CDS ML0563 NC_002677.1 680810 681706 D hypothetical protein 680810..681706 Mycobacterium leprae TN 909345 NP_301478.1 CDS ML0564 NC_002677.1 681703 682782 D hypothetical protein 681703..682782 Mycobacterium leprae TN 909346 NP_301479.1 CDS ML0565 NC_002677.1 682779 683756 D transcriptional regulator 682779..683756 Mycobacterium leprae TN 909347 NP_301480.1 CDS ML0568 NC_002677.1 686813 687406 D hypothetical protein 686813..687406 Mycobacterium leprae TN 909350 NP_301481.1 CDS ML0569 NC_002677.1 693611 694426 R hypothetical protein complement(693611..694426) Mycobacterium leprae TN 908975 NP_301482.1 CDS gap NC_002677.1 694889 695908 D catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 694889..695908 Mycobacterium leprae TN 909341 NP_301483.1 CDS pgk NC_002677.1 695911 697161 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 695911..697161 Mycobacterium leprae TN 909304 NP_301484.1 CDS tpiA NC_002677.1 697158 697943 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 697158..697943 Mycobacterium leprae TN 909354 NP_301485.1 CDS ML0573 NC_002677.1 697927 698202 D hypothetical protein 697927..698202 Mycobacterium leprae TN 909355 NP_301486.1 CDS ML0574 NC_002677.1 698199 698516 D hypothetical protein 698199..698516 Mycobacterium leprae TN 909356 NP_301487.1 CDS ML0575 NC_002677.1 698674 698892 D hypothetical protein 698674..698892 Mycobacterium leprae TN 909357 NP_301488.1 CDS ML0576 NC_002677.1 699708 699938 D hypothetical protein 699708..699938 Mycobacterium leprae TN 909358 NP_301489.1 CDS secG NC_002677.1 699950 700183 D preprotein translocase subunit SecG 699950..700183 Mycobacterium leprae TN 909359 NP_301490.1 CDS ppc NC_002677.1 700214 703018 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 700214..703018 Mycobacterium leprae TN 909360 NP_301491.1 CDS pgl NC_002677.1 703242 703985 R catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone; 6-phosphogluconolactonase complement(703242..703985) Mycobacterium leprae TN 910133 NP_301492.1 CDS ML0580 NC_002677.1 704001 704798 R hypothetical protein complement(704001..704798) Mycobacterium leprae TN 910130 NP_301493.1 CDS tal NC_002677.1 706461 707588 R catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase complement(706461..707588) Mycobacterium leprae TN 910135 NP_301494.1 CDS tkt NC_002677.1 707605 709704 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(707605..709704) Mycobacterium leprae TN 910090 NP_301495.1 CDS ctaB NC_002677.1 709904 710869 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 709904..710869 Mycobacterium leprae TN 908800 NP_301496.1 CDS ML0587 NC_002677.1 712668 713603 R hypothetical protein complement(712668..713603) Mycobacterium leprae TN 908788 NP_301497.1 CDS ML0588 NC_002677.1 713858 714100 D hypothetical protein 713858..714100 Mycobacterium leprae TN 909363 NP_301498.1 CDS ML0589 NC_002677.1 714234 715031 R hypothetical protein complement(714234..715031) Mycobacterium leprae TN 909364 NP_301499.1 CDS ML0590 NC_002677.1 715031 715978 R ABC transporter ATP-binding protein complement(715031..715978) Mycobacterium leprae TN 909361 NP_301500.1 CDS ML0591 NC_002677.1 715975 717756 R hypothetical protein complement(715975..717756) Mycobacterium leprae TN 909367 NP_301501.1 CDS ML0592 NC_002677.1 717872 718636 D DNA-binding protein 717872..718636 Mycobacterium leprae TN 909368 NP_301502.1 CDS ML0593 NC_002677.1 718688 721297 D hypothetical protein 718688..721297 Mycobacterium leprae TN 909370 NP_301503.1 CDS ML0594 NC_002677.1 721294 722472 D hypothetical protein 721294..722472 Mycobacterium leprae TN 909372 NP_301504.1 CDS ML0595 NC_002677.1 722469 723251 D ABC transporter ATP-binding protein 722469..723251 Mycobacterium leprae TN 909374 NP_301505.1 CDS ML0596 NC_002677.1 723254 724510 D aminotransferase 723254..724510 Mycobacterium leprae TN 909377 NP_301506.1 CDS ML0597 NC_002677.1 724507 725004 D hypothetical protein 724507..725004 Mycobacterium leprae TN 909378 NP_301507.1 CDS ML0598 NC_002677.1 724979 725326 D hypothetical protein 724979..725326 Mycobacterium leprae TN 909379 NP_301508.1 CDS ML0603 NC_002677.1 735002 736117 D hypothetical protein 735002..736117 Mycobacterium leprae TN 909387 NP_301509.1 CDS rpsT NC_002677.1 736154 736414 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(736154..736414) Mycobacterium leprae TN 909389 NP_301510.1 CDS ML0605 NC_002677.1 736549 738234 D hypothetical protein 736549..738234 Mycobacterium leprae TN 909390 NP_301511.1 CDS ML0606 NC_002677.1 738234 739211 D hypothetical protein 738234..739211 Mycobacterium leprae TN 909392 NP_301512.1 CDS ML0607 NC_002677.1 739211 740050 D hypothetical protein 739211..740050 Mycobacterium leprae TN 909393 NP_301513.1 CDS lepA NC_002677.1 742716 744656 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 742716..744656 Mycobacterium leprae TN 910558 NP_301514.1 CDS ML0614 NC_002677.1 747777 748064 D hypothetical protein 747777..748064 Mycobacterium leprae TN 909397 NP_301515.1 CDS subI NC_002677.1 748382 749428 D sulfate-binding protein 748382..749428 Mycobacterium leprae TN 909396 NP_301516.1 CDS mtb12 NC_002677.1 753532 754035 D hypothetical protein 753532..754035 Mycobacterium leprae TN 910360 NP_301517.1 CDS hrcA NC_002677.1 756770 757801 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 756770..757801 Mycobacterium leprae TN 909400 NP_301518.1 CDS dnaJ2 NC_002677.1 757873 759009 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 757873..759009 Mycobacterium leprae TN 909409 NP_301519.1 CDS ML0626 NC_002677.1 759041 759814 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 759041..759814 Mycobacterium leprae TN 909410 NP_301520.1 CDS phoH NC_002677.1 760114 761163 D phoH-family protein 760114..761163 Mycobacterium leprae TN 909408 NP_301521.1 CDS ML0628 NC_002677.1 761194 761730 D metalloprotease 761194..761730 Mycobacterium leprae TN 909407 NP_301522.1 CDS ML0630 NC_002677.1 763032 763358 D hypothetical protein 763032..763358 Mycobacterium leprae TN 909413 NP_301523.1 CDS era NC_002677.1 763476 764384 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 763476..764384 Mycobacterium leprae TN 910407 NP_301524.1 CDS recO NC_002677.1 765911 766717 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 765911..766717 Mycobacterium leprae TN 909415 NP_301525.1 CDS ML0634 NC_002677.1 766710 767600 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 766710..767600 Mycobacterium leprae TN 909416 NP_301526.1 CDS uvrD2 NC_002677.1 769118 771271 D ATP-dependent DNA helicase 769118..771271 Mycobacterium leprae TN 909420 NP_301527.1 CDS ML0638 NC_002677.1 771426 771728 D hypothetical protein 771426..771728 Mycobacterium leprae TN 909421 NP_301528.1 CDS whiB7 NC_002677.1 771722 771991 D transcriptional regulator 771722..771991 Mycobacterium leprae TN 909422 NP_301529.1 CDS ML0640 NC_002677.1 772068 773489 R hypothetical protein complement(772068..773489) Mycobacterium leprae TN 909423 NP_301530.1 CDS ML0642 NC_002677.1 774506 775945 R hypothetical protein complement(774506..775945) Mycobacterium leprae TN 909425 NP_301531.1 CDS ML0643 NC_002677.1 776008 777030 D hypothetical protein 776008..777030 Mycobacterium leprae TN 909426 NP_301532.1 CDS ML0644 NC_002677.1 777176 780127 D hypothetical protein 777176..780127 Mycobacterium leprae TN 909429 NP_301533.1 CDS ML0656 NC_002677.1 793592 793873 R hypothetical protein complement(793592..793873) Mycobacterium leprae TN 909452 NP_301534.1 CDS ML0659 NC_002677.1 795537 795863 R hypothetical protein complement(795537..795863) Mycobacterium leprae TN 909706 NP_301535.1 CDS fadE23 NC_002677.1 796047 797249 R acyl-CoA dehydrogenase complement(796047..797249) Mycobacterium leprae TN 909456 NP_301536.1 CDS fadE24 NC_002677.1 797292 798689 R acyl-CoA dehydrogenase complement(797292..798689) Mycobacterium leprae TN 910512 NP_301537.1 CDS ML0662 NC_002677.1 798766 799533 R monophosphatase complement(798766..799533) Mycobacterium leprae TN 909457 NP_301538.1 CDS ML0663 NC_002677.1 799661 799975 D hypothetical protein 799661..799975 Mycobacterium leprae TN 910295 NP_301539.1 CDS ML0664 NC_002677.1 800116 800379 D hypothetical protein 800116..800379 Mycobacterium leprae TN 910570 NP_301540.1 CDS fprA NC_002677.1 801976 803346 R NADPH-ferredoxin reductase complement(801976..803346) Mycobacterium leprae TN 910559 NP_301541.1 CDS prfB NC_002677.1 803526 804650 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 803526..804650 Mycobacterium leprae TN 909702 NP_301542.1 CDS ftsE NC_002677.1 805920 806609 D cell division ATP-binding protein 805920..806609 Mycobacterium leprae TN 909691 NP_301543.1 CDS ftsX NC_002677.1 806610 807503 D hypothetical protein 806610..807503 Mycobacterium leprae TN 909655 NP_301544.1 CDS smpB NC_002677.1 807506 807988 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 807506..807988 Mycobacterium leprae TN 910083 NP_301545.1 CDS folD NC_002677.1 810692 811540 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 810692..811540 Mycobacterium leprae TN 909678 NP_301546.1 CDS ML0675 NC_002677.1 811543 811818 D hypothetical protein 811543..811818 Mycobacterium leprae TN 909684 NP_301547.1 CDS ML0676 NC_002677.1 811815 812291 R hypothetical protein complement(811815..812291) Mycobacterium leprae TN 909672 NP_301548.1 CDS ML0678 NC_002677.1 813432 813959 R hypothetical protein complement(813432..813959) Mycobacterium leprae TN 909687 NP_301549.1 CDS ML0679 NC_002677.1 814145 814372 D hypothetical protein 814145..814372 Mycobacterium leprae TN 909686 NP_301550.1 CDS metX NC_002677.1 817109 818257 R Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase complement(817109..818257) Mycobacterium leprae TN 909449 NP_301551.1 CDS ML0685 NC_002677.1 821179 822090 R hydrolase complement(821179..822090) Mycobacterium leprae TN 909572 NP_301552.1 CDS trpS NC_002677.1 822126 823157 D catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 822126..823157 Mycobacterium leprae TN 909578 NP_301553.1 CDS ML0687 NC_002677.1 823169 824110 D hypothetical protein 823169..824110 Mycobacterium leprae TN 909584 NP_301554.1 CDS ML0691 NC_002677.1 827877 829112 R D-alanyl-D-alanine carboxypeptidase complement(827877..829112) Mycobacterium leprae TN 909585 NP_301555.1 CDS sdhB NC_002677.1 833872 834666 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit complement(833872..834666) Mycobacterium leprae TN 909587 NP_301556.1 CDS sdhA NC_002677.1 834666 836420 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit complement(834666..836420) Mycobacterium leprae TN 909594 NP_301557.1 CDS sdhD NC_002677.1 836441 836932 R succinate dehydrogenase hydrophobic membrane anchor protei complement(836441..836932) Mycobacterium leprae TN 909593 NP_301558.1 CDS sdhC NC_002677.1 836929 837390 R succinate dehydrogenase cytochrome B-556 subunit complement(836929..837390) Mycobacterium leprae TN 909592 NP_301559.1 CDS add NC_002677.1 837679 838767 D catalyzes the formation of inosine from adenosine; adenosine deaminase 837679..838767 Mycobacterium leprae TN 910518 NP_301560.1 CDS ML0703 NC_002677.1 840882 842153 R hypothetical protein complement(840882..842153) Mycobacterium leprae TN 909630 NP_301561.1 CDS pmmB NC_002677.1 843847 845463 R phospho-sugar mutase complement(843847..845463) Mycobacterium leprae TN 909595 NP_301562.1 CDS deoD NC_002677.1 845460 846266 R catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase complement(845460..846266) Mycobacterium leprae TN 910380 NP_301563.1 CDS ML0711 NC_002677.1 849828 850307 R hypothetical protein complement(849828..850307) Mycobacterium leprae TN 909650 NP_301564.1 CDS glpD NC_002677.1 851948 853705 D glycerol-3-phosphate dehydrogenase 851948..853705 Mycobacterium leprae TN 909648 NP_301565.1 CDS lpqC NC_002677.1 854776 855690 D hydrolase 854776..855690 Mycobacterium leprae TN 909652 NP_301566.1 CDS ML0717 NC_002677.1 859917 860588 R TetR family transcriptional regulator complement(859917..860588) Mycobacterium leprae TN 909660 NP_301567.1 CDS bccA NC_002677.1 867696 869492 R acetyl/propionyl CoA carboxylase subunit alpha complement(867696..869492) Mycobacterium leprae TN 909662 NP_301568.1 CDS sseA NC_002677.1 870028 870918 R thiosulfate sulfurtransferase complement(870028..870918) Mycobacterium leprae TN 909669 NP_301569.1 CDS maf NC_002677.1 871119 871760 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(871119..871760) Mycobacterium leprae TN 909673 NP_301570.1 CDS ML0730 NC_002677.1 871757 872011 R Similar to Mycobacterium tuberculosis hypothetical 19.0 kda protein RV3281 OR MTCY71.21 TR:P96886 (EMBL:Z92771) fasta scores: E(): 2.4e-22, 69.0% id in 87 aa. Previously sequenced as TR:Q49671 (EMBL:U00012). Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain.; hypothetical protein complement(871757..872011) Mycobacterium leprae TN 909675 NP_301571.1 CDS accD5 NC_002677.1 872008 873657 R acetyl/propionyl CoA carboxylase subunit beta complement(872008..873657) Mycobacterium leprae TN 909674 NP_301572.1 CDS birA NC_002677.1 873720 874544 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 873720..874544 Mycobacterium leprae TN 909679 NP_301573.1 CDS ML0733 NC_002677.1 874677 875195 D hypothetical protein 874677..875195 Mycobacterium leprae TN 909677 NP_301574.1 CDS ML0734 NC_002677.1 875150 875836 R hypothetical protein complement(875150..875836) Mycobacterium leprae TN 909676 NP_301575.1 CDS purK NC_002677.1 875924 877243 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 875924..877243 Mycobacterium leprae TN 909683 NP_301576.1 CDS purE NC_002677.1 877243 877758 D Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 877243..877758 Mycobacterium leprae TN 909681 NP_301577.1 CDS fadE25 NC_002677.1 877853 879022 D acyl-CoA dehydrogenase 877853..879022 Mycobacterium leprae TN 909685 NP_301578.1 CDS ctpC NC_002677.1 888793 890970 R cation transport ATPase complement(888793..890970) Mycobacterium leprae TN 909697 NP_301579.1 CDS ML0748 NC_002677.1 890981 891259 R hypothetical protein complement(890981..891259) Mycobacterium leprae TN 909701 NP_301580.1 CDS ML0750 NC_002677.1 892063 893532 R hypothetical protein complement(892063..893532) Mycobacterium leprae TN 909705 NP_301581.1 CDS rmlD NC_002677.1 893621 894556 D dTDP-rhamnose modification protein 893621..894556 Mycobacterium leprae TN 909704 NP_301582.1 CDS wbbL NC_002677.1 894549 895475 D dTDP-rhamnosyl transferase 894549..895475 Mycobacterium leprae TN 909703 NP_301583.1 CDS rmlA2 NC_002677.1 895477 896553 D sugar-phosphate nucleotidyl transferase 895477..896553 Mycobacterium leprae TN 909707 NP_301584.1 CDS ML0755 NC_002677.1 897493 897753 R hypothetical protein complement(897493..897753) Mycobacterium leprae TN 909709 NP_301585.1 CDS ML0756 NC_002677.1 897971 899638 R DNA methylase complement(897971..899638) Mycobacterium leprae TN 909708 NP_301586.1 CDS ML0757 NC_002677.1 899660 900352 R hypothetical protein complement(899660..900352) Mycobacterium leprae TN 909715 NP_301587.1 CDS ML0758 NC_002677.1 900393 901766 R catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase complement(900393..901766) Mycobacterium leprae TN 909714 NP_301588.1 CDS ML0759 NC_002677.1 901763 902902 R catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase complement(901763..902902) Mycobacterium leprae TN 909719 NP_301589.1 CDS whiB2 NC_002677.1 903227 903496 D transcriptional regulator 903227..903496 Mycobacterium leprae TN 909718 NP_301590.1 CDS ML0761 NC_002677.1 903525 904028 R hypothetical protein complement(903525..904028) Mycobacterium leprae TN 909716 NP_301591.1 CDS ML0762 NC_002677.1 904068 904565 D hypothetical protein 904068..904565 Mycobacterium leprae TN 909717 NP_301592.1 CDS manB NC_002677.1 904675 906081 D converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 904675..906081 Mycobacterium leprae TN 909722 NP_301593.1 CDS ML0764 NC_002677.1 906078 907175 D hypothetical protein 906078..907175 Mycobacterium leprae TN 909721 NP_301594.1 CDS manA NC_002677.1 907183 908415 D mannose-6-phosphate isomerase 907183..908415 Mycobacterium leprae TN 909724 NP_301595.1 CDS sahH NC_002677.1 913623 915101 D catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 913623..915101 Mycobacterium leprae TN 910325 NP_301596.1 CDS tmk NC_002677.1 915144 915776 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 915144..915776 Mycobacterium leprae TN 909725 NP_301597.1 CDS mtrA NC_002677.1 915869 916555 D two-component response regulator 915869..916555 Mycobacterium leprae TN 909727 NP_301598.1 CDS mtrB NC_002677.1 916683 918371 D two-component system sensor kinase 916683..918371 Mycobacterium leprae TN 909729 NP_301599.1 CDS lpqB NC_002677.1 918368 920137 D lipoprotein LpqB 918368..920137 Mycobacterium leprae TN 909733 NP_301600.1 CDS ML0776 NC_002677.1 920258 920515 D Similar to the N-terminal half of Mycobacterium tuberculosis hypothetical 22.5 kDa protein RV3242C OR MTCY20B11.17C TR:O05887 (EMBL:Z95121) fasta scores: E(): 6.8e-18, 78.1% id in 64 aa.; hypothetical protein 920258..920515 Mycobacterium leprae TN 909732 NP_301601.1 CDS ML0777 NC_002677.1 920655 920849 D hypothetical protein 920655..920849 Mycobacterium leprae TN 909737 NP_301602.1 CDS ML0778 NC_002677.1 920953 921642 D hypothetical protein 920953..921642 Mycobacterium leprae TN 909736 NP_301603.1 CDS secA NC_002677.1 921722 924544 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 921722..924544 Mycobacterium leprae TN 909735 NP_301604.1 CDS ML0781 NC_002677.1 925681 926163 D hypothetical protein 925681..926163 Mycobacterium leprae TN 909739 NP_301605.1 CDS ML0782 NC_002677.1 926168 927325 D transmembrane transport protein 926168..927325 Mycobacterium leprae TN 909743 NP_301606.1 CDS ML0791 NC_002677.1 934528 935511 R hypothetical protein complement(934528..935511) Mycobacterium leprae TN 909747 NP_301607.1 CDS aroA NC_002677.1 935508 936800 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(935508..936800) Mycobacterium leprae TN 909741 NP_301608.1 CDS ML0793 NC_002677.1 936847 937605 D bacteriophage protein 936847..937605 Mycobacterium leprae TN 909750 NP_301609.1 CDS ML0796 NC_002677.1 942266 942442 D hypothetical protein 942266..942442 Mycobacterium leprae TN 909753 NP_301610.1 CDS ML0798 NC_002677.1 946524 948302 R hypothetical protein complement(946524..948302) Mycobacterium leprae TN 909755 NP_301611.1 CDS ML0799 NC_002677.1 949041 949448 R hypothetical protein complement(949041..949448) Mycobacterium leprae TN 909757 NP_301612.1 CDS ML0802 NC_002677.1 951814 952053 D acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 951814..952053 Mycobacterium leprae TN 909760 NP_301613.1 CDS ML0803 NC_002677.1 952103 953605 D two-component system sensor kinase 952103..953605 Mycobacterium leprae TN 909761 NP_301614.1 CDS whiB1 NC_002677.1 953665 953919 R transcriptional regulator complement(953665..953919) Mycobacterium leprae TN 909762 NP_301615.1 CDS ML0806 NC_002677.1 955206 955727 D hypothetical protein 955206..955727 Mycobacterium leprae TN 909764 NP_301616.2 CDS entC NC_002677.1 956155 957315 R synthesizes isochorismate acid from chorismate; isochorismate synthase complement(956155..957315) Mycobacterium leprae TN 909766 NP_301617.1 CDS ML0810 NC_002677.1 958882 960105 R hypothetical protein complement(958882..960105) Mycobacterium leprae TN 909768 NP_301618.1 CDS rhlE NC_002677.1 960117 961751 R ATP-dependent RNA helicase complement(960117..961751) Mycobacterium leprae TN 910320 NP_301619.1 CDS ML0813 NC_002677.1 962707 963294 R hypothetical protein complement(962707..963294) Mycobacterium leprae TN 909771 NP_301620.1 CDS ML0814 NC_002677.1 963593 963841 D hypothetical protein 963593..963841 Mycobacterium leprae TN 909772 NP_301621.1 CDS ML0815 NC_002677.1 963828 964514 R TetR family transcriptional regulator complement(963828..964514) Mycobacterium leprae TN 909773 NP_301622.1 CDS ML0816 NC_002677.1 964701 965726 D hypothetical protein 964701..965726 Mycobacterium leprae TN 909774 NP_301623.1 CDS moeZ NC_002677.1 965930 967117 D The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 965930..967117 Mycobacterium leprae TN 909775 NP_301624.1 CDS ML0818 NC_002677.1 967172 968065 D hypothetical protein 967172..968065 Mycobacterium leprae TN 909776 NP_301625.1 CDS furB NC_002677.1 977783 978178 R ferric uptake regulatory protein complement(977783..978178) Mycobacterium leprae TN 909782 NP_301626.1 CDS ML0825 NC_002677.1 978252 978674 R ArsR family transcriptional regulator complement(978252..978674) Mycobacterium leprae TN 909783 NP_301627.1 CDS glyS NC_002677.1 978841 980232 D Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 978841..980232 Mycobacterium leprae TN 909851 NP_301628.1 CDS dgt NC_002677.1 986474 987763 D dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 986474..987763 Mycobacterium leprae TN 909794 NP_301629.1 CDS dnaG NC_002677.1 988458 990386 D synthesizes RNA primers at the replication forks; DNA primase 988458..990386 Mycobacterium leprae TN 909792 NP_301630.1 CDS ML0834 NC_002677.1 990401 990703 R hypothetical protein complement(990401..990703) Mycobacterium leprae TN 909789 NP_301631.1 CDS ML0837 NC_002677.1 993882 994265 D hypothetical protein 993882..994265 Mycobacterium leprae TN 909800 NP_301632.1 CDS cysE NC_002677.1 995670 996353 R serine acetyltransferase complement(995670..996353) Mycobacterium leprae TN 909803 NP_301633.1 CDS cysK NC_002677.1 996356 997288 R cysteine synthase complement(996356..997288) Mycobacterium leprae TN 909810 NP_301634.1 CDS ML0840 NC_002677.1 997285 998589 R hypothetical protein complement(997285..998589) Mycobacterium leprae TN 909770 NP_301635.1 CDS ML0841 NC_002677.1 998972 999895 D major membrane protein I 998972..999895 Mycobacterium leprae TN 909812 NP_301636.1 CDS ML0842 NC_002677.1 1000551 1001786 D hypothetical protein 1000551..1001786 Mycobacterium leprae TN 909813 NP_301637.1 CDS narK NC_002677.1 1002559 1004112 D nitrite extrusion protein 1002559..1004112 Mycobacterium leprae TN 909819 NP_301638.1 CDS ML0845 NC_002677.1 1004100 1004681 R hypothetical protein complement(1004100..1004681) Mycobacterium leprae TN 909821 NP_301639.1 CDS ML0848 NC_002677.1 1005906 1008080 D ABC transporter 1005906..1008080 Mycobacterium leprae TN 909826 NP_301640.1 CDS ML0849 NC_002677.1 1008077 1008928 D hypothetical protein 1008077..1008928 Mycobacterium leprae TN 909832 NP_301641.1 CDS ribF NC_002677.1 1012135 1013130 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1012135..1013130 Mycobacterium leprae TN 909839 NP_301642.1 CDS rpsO NC_002677.1 1013248 1013517 D primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1013248..1013517 Mycobacterium leprae TN 909842 NP_301643.1 CDS gpsI NC_002677.1 1013839 1016160 D polynucleotide phosphorylase 1013839..1016160 Mycobacterium leprae TN 909849 NP_301644.1 CDS pepR NC_002677.1 1016249 1017523 D zinc protease 1016249..1017523 Mycobacterium leprae TN 909854 NP_301645.1 CDS ML0857 NC_002677.1 1019690 1020442 R hypothetical protein complement(1019690..1020442) Mycobacterium leprae TN 909853 NP_301646.1 CDS lipA NC_002677.1 1020469 1021413 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(1020469..1021413) Mycobacterium leprae TN 909865 NP_301647.1 CDS lipB NC_002677.1 1021410 1022117 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(1021410..1022117) Mycobacterium leprae TN 909866 NP_301648.1 CDS ML0860 NC_002677.1 1022182 1023105 R hypothetical protein complement(1022182..1023105) Mycobacterium leprae TN 909856 NP_301649.1 CDS dlaT NC_002677.1 1023121 1024713 R E2 component; part of pyruvate dehydrogenase; forms a complex with AceA and LpdC; dihydrolipoamide acetyltransferase complement(1023121..1024713) Mycobacterium leprae TN 909857 NP_301650.1 CDS ephD NC_002677.1 1024953 1026743 D short chain dehydrogenase 1024953..1026743 Mycobacterium leprae TN 909858 NP_301651.1 CDS ML0863 NC_002677.1 1026901 1027215 D hypothetical protein 1026901..1027215 Mycobacterium leprae TN 909861 NP_301652.1 CDS pepA NC_002677.1 1027286 1028860 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(1027286..1028860) Mycobacterium leprae TN 909860 NP_301653.1 CDS gcvT NC_002677.1 1029021 1030124 D catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 1029021..1030124 Mycobacterium leprae TN 908708 NP_301654.1 CDS ilvE NC_002677.1 1030181 1031287 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1030181..1031287 Mycobacterium leprae TN 909864 NP_301655.1 CDS cobT NC_002677.1 1032056 1033111 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(1032056..1033111) Mycobacterium leprae TN 909862 NP_301656.1 CDS ML0869 NC_002677.1 1033201 1033575 R hypothetical protein complement(1033201..1033575) Mycobacterium leprae TN 909869 NP_301657.1 CDS ML0871 NC_002677.1 1035224 1035580 D hypothetical protein 1035224..1035580 Mycobacterium leprae TN 909873 NP_301658.1 CDS ML0872 NC_002677.1 1035615 1036130 R hypothetical protein complement(1035615..1036130) Mycobacterium leprae TN 909872 NP_301659.1 CDS ML0873 NC_002677.1 1036449 1037423 D carbohydrate kinase 1036449..1037423 Mycobacterium leprae TN 909871 NP_301660.1 CDS asnB NC_002677.1 1037606 1039639 R asparagine synthetase complement(1037606..1039639) Mycobacterium leprae TN 909875 NP_301661.1 CDS ctaC NC_002677.1 1039782 1040843 D cytochrome C oxidase chain II 1039782..1040843 Mycobacterium leprae TN 909877 NP_301662.1 CDS ML0876 NC_002677.1 1040896 1041315 D hypothetical protein 1040896..1041315 Mycobacterium leprae TN 909880 NP_301663.1 CDS mmpS3 NC_002677.1 1041502 1042383 D hypothetical protein 1041502..1042383 Mycobacterium leprae TN 909879 NP_301664.1 CDS ML0878 NC_002677.1 1042383 1043021 D hypothetical protein 1042383..1043021 Mycobacterium leprae TN 909876 NP_301665.1 CDS qcrB NC_002677.1 1043155 1044810 R cytochrome B complement(1043155..1044810) Mycobacterium leprae TN 909878 NP_301666.1 CDS qcrA NC_002677.1 1044807 1045991 R Rieske iron-sulfur reductase component complement(1044807..1045991) Mycobacterium leprae TN 909874 NP_301667.1 CDS qcrC NC_002677.1 1045988 1046857 R cytochrome C reductase cytochrome C component complement(1045988..1046857) Mycobacterium leprae TN 909882 NP_301668.1 CDS ctaE NC_002677.1 1046919 1047527 R cytochrome C oxidase subunit III complement(1046919..1047527) Mycobacterium leprae TN 909884 NP_301669.1 CDS trpD NC_002677.1 1047664 1048764 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1047664..1048764 Mycobacterium leprae TN 909885 NP_301670.1 CDS ML0885 NC_002677.1 1050963 1052087 D hypothetical protein 1050963..1052087 Mycobacterium leprae TN 909881 NP_301671.1 CDS ML0886 NC_002677.1 1052132 1053286 D glycosyl transferase family protein 1052132..1053286 Mycobacterium leprae TN 909887 NP_301672.1 CDS ML0887 NC_002677.1 1053283 1055085 R The C-terminus of the predicted product of; long-chain-fatty-acid-CoA ligase complement(1053283..1055085) Mycobacterium leprae TN 909888 NP_301673.1 CDS ML0888 NC_002677.1 1055260 1055667 D hypothetical protein 1055260..1055667 Mycobacterium leprae TN 909889 NP_301674.1 CDS ML0889 NC_002677.1 1055786 1056220 D hypothetical protein 1055786..1056220 Mycobacterium leprae TN 909890 NP_301675.1 CDS ML0890 NC_002677.1 1056241 1057488 D membrane transporter ATPase 1056241..1057488 Mycobacterium leprae TN 909892 NP_301676.1 CDS ML0891 NC_002677.1 1057485 1057877 D hypothetical protein 1057485..1057877 Mycobacterium leprae TN 909893 NP_301677.1 CDS ML0892 NC_002677.1 1057963 1058697 D acyltransferase 1057963..1058697 Mycobacterium leprae TN 909891 NP_301678.1 CDS ML0893 NC_002677.1 1058705 1059991 R hypothetical protein complement(1058705..1059991) Mycobacterium leprae TN 908616 NP_301679.1 CDS ML0895 NC_002677.1 1061008 1061523 D hypothetical protein 1061008..1061523 Mycobacterium leprae TN 909896 NP_301680.1 CDS aroG NC_002677.1 1061587 1062975 D DAHP synthetase; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase 1061587..1062975 Mycobacterium leprae TN 909897 NP_301681.1 CDS ML0897 NC_002677.1 1062988 1064190 R serine-threonine protein kinase complement(1062988..1064190) Mycobacterium leprae TN 909898 NP_301682.1 CDS ML0898 NC_002677.1 1064343 1064747 D DNA-binding protein 1064343..1064747 Mycobacterium leprae TN 909899 NP_301683.1 CDS ML0899 NC_002677.1 1064744 1066261 R integral-membrane protein complement(1064744..1066261) Mycobacterium leprae TN 909900 NP_301684.1 CDS ML0901 NC_002677.1 1067600 1068514 D hypothetical protein 1067600..1068514 Mycobacterium leprae TN 909903 NP_301685.1 CDS ML0902 NC_002677.1 1068511 1069230 R lipoprotein complement(1068511..1069230) Mycobacterium leprae TN 909904 NP_301686.1 CDS ML0903 NC_002677.1 1069302 1069934 R hypothetical protein complement(1069302..1069934) Mycobacterium leprae TN 909906 NP_301687.1 CDS ML0904 NC_002677.1 1070251 1070655 D hypothetical protein 1070251..1070655 Mycobacterium leprae TN 908710 NP_301688.1 CDS ML0905 NC_002677.1 1071028 1071459 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1071028..1071459 Mycobacterium leprae TN 908666 NP_301689.1 CDS mraW NC_002677.1 1071587 1072705 D S-adenosyl-methyltransferase MraW 1071587..1072705 Mycobacterium leprae TN 909902 NP_301690.1 CDS ML0907 NC_002677.1 1072702 1073835 D hypothetical protein 1072702..1073835 Mycobacterium leprae TN 909908 NP_301691.1 CDS pbpB NC_002677.1 1073832 1075859 D penicillin-binding protein 2 1073832..1075859 Mycobacterium leprae TN 909909 NP_301692.1 CDS murE NC_002677.1 1076001 1077593 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1076001..1077593 Mycobacterium leprae TN 909910 NP_301693.1 CDS murF NC_002677.1 1077590 1079143 D UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanyl ligase (D-alanine:D-alanine-adding enzyme) 1077590..1079143 Mycobacterium leprae TN 909915 NP_301694.1 CDS mraY NC_002677.1 1079140 1080219 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1079140..1080219 Mycobacterium leprae TN 909907 NP_301695.1 CDS murD NC_002677.1 1080221 1081693 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1080221..1081693 Mycobacterium leprae TN 909911 NP_301696.1 CDS ftsW NC_002677.1 1081700 1083304 D cell division protein FtsW 1081700..1083304 Mycobacterium leprae TN 909914 NP_301697.1 CDS murG NC_002677.1 1083301 1084524 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1083301..1084524 Mycobacterium leprae TN 909917 NP_301698.1 CDS murC NC_002677.1 1084521 1086008 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1084521..1086008 Mycobacterium leprae TN 909916 NP_301699.1 CDS ML0916 NC_002677.1 1086005 1087030 D cell division protein FtsQ 1086005..1087030 Mycobacterium leprae TN 909913 NP_301700.1 CDS ftsZ NC_002677.1 1087296 1088435 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1087296..1088435 Mycobacterium leprae TN 909912 NP_301701.1 CDS ML0918 NC_002677.1 1088458 1089207 D hypothetical protein 1088458..1089207 Mycobacterium leprae TN 909920 NP_301702.1 CDS ML0919 NC_002677.1 1089204 1089986 D DNA-binding protein 1089204..1089986 Mycobacterium leprae TN 909919 NP_301703.1 CDS ML0920 NC_002677.1 1090054 1090686 D hypothetical protein 1090054..1090686 Mycobacterium leprae TN 909918 NP_301704.1 CDS ML0921 NC_002677.1 1090811 1091101 D hypothetical protein 1090811..1091101 Mycobacterium leprae TN 909921 NP_301705.1 CDS ag84 NC_002677.1 1091348 1092148 D hypothetical protein 1091348..1092148 Mycobacterium leprae TN 909922 NP_301706.1 CDS ML0923 NC_002677.1 1092221 1092613 D hypothetical protein 1092221..1092613 Mycobacterium leprae TN 909923 NP_301707.1 CDS glnA NC_002677.1 1094376 1095812 D glutamine synthase class I 1094376..1095812 Mycobacterium leprae TN 909848 NP_301708.1 CDS ML0926 NC_002677.1 1096064 1096432 R hypothetical protein complement(1096064..1096432) Mycobacterium leprae TN 909929 NP_301709.1 CDS ML0927 NC_002677.1 1096524 1096832 R hypothetical protein complement(1096524..1096832) Mycobacterium leprae TN 909930 NP_301710.1 CDS ML0928 NC_002677.1 1098053 1098337 D hypothetical protein 1098053..1098337 Mycobacterium leprae TN 909932 NP_301711.1 CDS ML0938 NC_002677.1 1109892 1110188 D hypothetical protein 1109892..1110188 Mycobacterium leprae TN 909943 NP_301712.1 CDS ML0939 NC_002677.1 1110185 1110427 D hypothetical protein 1110185..1110427 Mycobacterium leprae TN 909944 NP_301713.1 CDS ML0946 NC_002677.1 1116230 1116553 D hypothetical protein 1116230..1116553 Mycobacterium leprae TN 909955 NP_301714.1 CDS ML0947 NC_002677.1 1117520 1117777 R hypothetical protein complement(1117520..1117777) Mycobacterium leprae TN 909956 NP_301715.1 CDS ML0949 NC_002677.1 1118730 1119143 R hypothetical protein complement(1118730..1119143) Mycobacterium leprae TN 909958 NP_301716.1 CDS ML0950 NC_002677.1 1119155 1119355 R hypothetical protein complement(1119155..1119355) Mycobacterium leprae TN 909959 NP_301717.1 CDS ML0953 NC_002677.1 1121893 1122132 D hypothetical protein 1121893..1122132 Mycobacterium leprae TN 909962 NP_301718.1 CDS ppdK NC_002677.1 1123017 1124822 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase complement(1123017..1124822) Mycobacterium leprae TN 909964 NP_301719.1 CDS ML0956 NC_002677.1 1124867 1125376 D hypothetical protein 1124867..1125376 Mycobacterium leprae TN 909966 NP_301720.1 CDS ML0957 NC_002677.1 1125854 1126228 R hypothetical protein complement(1125854..1126228) Mycobacterium leprae TN 909968 NP_301721.1 CDS ML0958 NC_002677.1 1126239 1126670 D hypothetical protein 1126239..1126670 Mycobacterium leprae TN 909969 NP_301722.1 CDS ML0959 NC_002677.1 1126912 1127265 D hypothetical protein 1126912..1127265 Mycobacterium leprae TN 909970 NP_301723.1 CDS metE NC_002677.1 1127777 1130059 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase complement(1127777..1130059) Mycobacterium leprae TN 909974 NP_301724.1 CDS ML0963 NC_002677.1 1131298 1131762 D hypothetical protein 1131298..1131762 Mycobacterium leprae TN 909977 NP_301725.1 CDS ML0964 NC_002677.1 1131800 1132057 D hypothetical protein 1131800..1132057 Mycobacterium leprae TN 909978 NP_301726.1 CDS ftsK NC_002677.1 1144496 1147156 D cell division protein 1144496..1147156 Mycobacterium leprae TN 909997 NP_301727.1 CDS ML0978 NC_002677.1 1147166 1147708 R catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase complement(1147166..1147708) Mycobacterium leprae TN 909998 NP_301728.1 CDS ML0979 NC_002677.1 1147775 1148356 D CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1147775..1148356 Mycobacterium leprae TN 909999 NP_301729.1 CDS ML0984 NC_002677.1 1151024 1151518 R hypothetical protein complement(1151024..1151518) Mycobacterium leprae TN 910006 NP_301730.1 CDS ML0985 NC_002677.1 1151510 1152688 D glycosyltransferase 1151510..1152688 Mycobacterium leprae TN 910007 NP_301731.1 CDS ML0986 NC_002677.1 1152702 1152905 D hypothetical protein 1152702..1152905 Mycobacterium leprae TN 910008 NP_301732.1 CDS recA NC_002677.1 1153056 1155191 D RecA protein 1153056..1155191 Mycobacterium leprae TN 910009 NP_301733.1 CDS recX NC_002677.1 1155157 1155672 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1155157..1155672 Mycobacterium leprae TN 910283 NP_301734.1 CDS ML0989 NC_002677.1 1155731 1157284 D catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1155731..1157284 Mycobacterium leprae TN 910281 NP_301735.1 CDS ML0990 NC_002677.1 1157281 1157910 D hypothetical protein 1157281..1157910 Mycobacterium leprae TN 910010 NP_301736.1 CDS ML0994 NC_002677.1 1162620 1163318 D hypothetical protein 1162620..1163318 Mycobacterium leprae TN 910015 NP_301737.1 CDS miaA NC_002677.1 1163315 1164250 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 1163315..1164250 Mycobacterium leprae TN 910017 NP_301738.1 CDS dapF NC_002677.1 1164317 1165207 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1164317..1165207 Mycobacterium leprae TN 910020 NP_301739.1 CDS ML0997 NC_002677.1 1165270 1166736 D ATP/GTP-binding protein 1165270..1166736 Mycobacterium leprae TN 910021 NP_301740.1 CDS ML1001 NC_002677.1 1172599 1172874 R hypothetical protein complement(1172599..1172874) Mycobacterium leprae TN 910031 NP_301741.1 CDS ML1002 NC_002677.1 1172919 1174982 D hypothetical protein 1172919..1174982 Mycobacterium leprae TN 910047 NP_301742.1 CDS lexA NC_002677.1 1175021 1175728 R Represses a number of genes involved in the response to DNA damage; LexA repressor complement(1175021..1175728) Mycobacterium leprae TN 910052 NP_301743.1 CDS ML1004 NC_002677.1 1176008 1176502 D hypothetical protein 1176008..1176502 Mycobacterium leprae TN 910065 NP_301744.1 CDS nrdR NC_002677.1 1176664 1177128 D transcriptional regulator NrdR 1176664..1177128 Mycobacterium leprae TN 910064 NP_301745.1 CDS ML1006 NC_002677.1 1177170 1177655 D hypothetical protein 1177170..1177655 Mycobacterium leprae TN 909391 NP_301746.1 CDS ML1009 NC_002677.1 1179519 1180499 R hypothetical protein complement(1179519..1180499) Mycobacterium leprae TN 910071 NP_301747.1 CDS ML1010 NC_002677.1 1180776 1181018 R hypothetical protein complement(1180776..1181018) Mycobacterium leprae TN 910070 NP_301748.1 CDS ML1011 NC_002677.1 1181058 1181480 R hypothetical protein complement(1181058..1181480) Mycobacterium leprae TN 910068 NP_301749.1 CDS ML1013 NC_002677.1 1183481 1184173 R iron dependent repressor complement(1183481..1184173) Mycobacterium leprae TN 910073 NP_301750.1 CDS ML1014 NC_002677.1 1184330 1185289 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB complement(1184330..1185289) Mycobacterium leprae TN 910072 NP_301751.1 CDS ML1015 NC_002677.1 1185456 1185875 R hypothetical protein complement(1185456..1185875) Mycobacterium leprae TN 910076 NP_301752.1 CDS ML1016 NC_002677.1 1185903 1186226 D hypothetical protein 1185903..1186226 Mycobacterium leprae TN 910075 NP_301753.1 CDS ML1017 NC_002677.1 1186213 1187205 R hypothetical protein complement(1186213..1187205) Mycobacterium leprae TN 910074 NP_301754.1 CDS ML1018 NC_002677.1 1187210 1187425 R hypothetical protein complement(1187210..1187425) Mycobacterium leprae TN 910079 NP_301755.1 CDS rpoT NC_002677.1 1189185 1190909 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor complement(1189185..1190909) Mycobacterium leprae TN 910077 NP_301756.1 CDS ppgK NC_002677.1 1190920 1191894 R polyphosphate glucokinase complement(1190920..1191894) Mycobacterium leprae TN 910085 NP_301757.1 CDS suhB NC_002677.1 1191843 1192718 D inositol monophosphatase 1191843..1192718 Mycobacterium leprae TN 910084 NP_301758.1 CDS ML1025 NC_002677.1 1192722 1193372 R hypothetical protein complement(1192722..1193372) Mycobacterium leprae TN 910089 NP_301759.1 CDS ML1026 NC_002677.1 1193568 1193870 D hypothetical protein 1193568..1193870 Mycobacterium leprae TN 910088 NP_301760.1 CDS ML1027 NC_002677.1 1193875 1194348 R hypothetical protein complement(1193875..1194348) Mycobacterium leprae TN 910087 NP_301761.1 CDS dut NC_002677.1 1194374 1194838 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1194374..1194838 Mycobacterium leprae TN 910096 NP_301762.1 CDS ML1029 NC_002677.1 1194835 1195656 D hypothetical protein 1194835..1195656 Mycobacterium leprae TN 910106 NP_301763.1 CDS ML1030 NC_002677.1 1195701 1196399 R hypothetical protein complement(1195701..1196399) Mycobacterium leprae TN 910112 NP_301764.1 CDS ML1036 NC_002677.1 1199237 1200526 R membrane transporter complement(1199237..1200526) Mycobacterium leprae TN 910118 NP_301765.1 CDS ML1037 NC_002677.1 1200579 1201133 R hypothetical protein complement(1200579..1201133) Mycobacterium leprae TN 910119 NP_301766.1 CDS dxs NC_002677.1 1201215 1203146 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1201215..1203146 Mycobacterium leprae TN 910120 NP_301767.1 CDS ML1040 NC_002677.1 1205247 1206536 R hypothetical protein complement(1205247..1206536) Mycobacterium leprae TN 910122 NP_301768.1 CDS ML1041 NC_002677.1 1206538 1207128 R hypothetical protein complement(1206538..1207128) Mycobacterium leprae TN 910123 NP_301769.1 CDS hemE NC_002677.1 1208217 1209290 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1208217..1209290 Mycobacterium leprae TN 910092 NP_301770.1 CDS hemY NC_002677.1 1209287 1210642 D catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 1209287..1210642 Mycobacterium leprae TN 910131 NP_301771.1 CDS ML1045 NC_002677.1 1210648 1211343 D hypothetical protein 1210648..1211343 Mycobacterium leprae TN 910132 NP_301772.1 CDS xclC NC_002677.1 1217109 1218539 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1217109..1218539 Mycobacterium leprae TN 910136 NP_301773.1 CDS ML1052 NC_002677.1 1218562 1219827 R hypothetical protein complement(1218562..1219827) Mycobacterium leprae TN 909334 NP_301774.1 CDS ML1053 NC_002677.1 1220374 1220673 D hypothetical protein 1220374..1220673 Mycobacterium leprae TN 910142 NP_301775.1 CDS ML1055 NC_002677.1 1221433 1221735 D hypothetical protein 1221433..1221735 Mycobacterium leprae TN 910144 NP_301776.1 CDS ML1056 NC_002677.1 1221787 1222074 D hypothetical protein 1221787..1222074 Mycobacterium leprae TN 910145 NP_301777.1 CDS ML1057 NC_002677.1 1222249 1222602 D hypothetical protein 1222249..1222602 Mycobacterium leprae TN 910146 NP_301778.1 CDS ML1058 NC_002677.1 1222693 1223646 R transferase complement(1222693..1223646) Mycobacterium leprae TN 910147 NP_301779.1 CDS dapE NC_002677.1 1223700 1224764 D catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1223700..1224764 Mycobacterium leprae TN 910148 NP_301780.1 CDS ML1061 NC_002677.1 1226442 1227005 D hypothetical protein 1226442..1227005 Mycobacterium leprae TN 910140 NP_301781.1 CDS folP2 NC_002677.1 1228776 1229651 D dihydropteroate synthase 1228776..1229651 Mycobacterium leprae TN 910150 NP_301782.1 CDS ML1064 NC_002677.1 1229648 1230628 D glucosyl-3-phosphoglycerate synthase 1229648..1230628 Mycobacterium leprae TN 910152 NP_301783.1 CDS ML1065 NC_002677.1 1230644 1230988 D hypothetical protein 1230644..1230988 Mycobacterium leprae TN 910151 NP_301784.1 CDS tagA NC_002677.1 1230985 1231563 D DNA-3-methyladenine glycosidase I 1230985..1231563 Mycobacterium leprae TN 910461 NP_301785.1 CDS ML1067 NC_002677.1 1231777 1232004 D hypothetical protein 1231777..1232004 Mycobacterium leprae TN 910153 NP_301786.1 CDS glgC NC_002677.1 1233349 1234563 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1233349..1234563 Mycobacterium leprae TN 910156 NP_301787.1 CDS ML1070 NC_002677.1 1234637 1235290 D TetR family transcriptional regulator 1234637..1235290 Mycobacterium leprae TN 910386 NP_301788.1 CDS ML1075 NC_002677.1 1238386 1239060 R O-methyltransferase complement(1238386..1239060) Mycobacterium leprae TN 910161 NP_301789.1 CDS sigE NC_002677.1 1239340 1240131 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 1239340..1240131 Mycobacterium leprae TN 910163 NP_301790.1 CDS ML1077 NC_002677.1 1240278 1240697 D hypothetical protein 1240278..1240697 Mycobacterium leprae TN 910162 NP_301791.1 CDS htrA NC_002677.1 1240772 1242373 D serine protease 1240772..1242373 Mycobacterium leprae TN 910155 NP_301792.1 CDS ML1079 NC_002677.1 1242373 1242735 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 1242373..1242735 Mycobacterium leprae TN 910165 NP_301793.1 CDS mrp NC_002677.1 1243755 1244906 R MRP family ATP-binding protein complement(1243755..1244906) Mycobacterium leprae TN 910166 NP_301794.1 CDS ML1086 NC_002677.1 1248325 1249731 D solute-binding transport lipoprotein 1248325..1249731 Mycobacterium leprae TN 910164 NP_301795.1 CDS ML1087 NC_002677.1 1249760 1250674 D ABC transporter inner membrane protein 1249760..1250674 Mycobacterium leprae TN 910174 NP_301796.1 CDS ML1088 NC_002677.1 1250664 1251527 D ABC transporter inner membrane protein 1250664..1251527 Mycobacterium leprae TN 910175 NP_301797.1 CDS ML1089 NC_002677.1 1251532 1252710 D ABC transporter ATP-binding protein 1251532..1252710 Mycobacterium leprae TN 910177 NP_301798.1 CDS ML1090 NC_002677.1 1253339 1254448 R membrane transporter complement(1253339..1254448) Mycobacterium leprae TN 910179 NP_301799.1 CDS mdh NC_002677.1 1254671 1255660 D catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1254671..1255660 Mycobacterium leprae TN 910180 NP_301800.1 CDS ML1093 NC_002677.1 1257729 1258586 D lipoprotein 1257729..1258586 Mycobacterium leprae TN 910184 NP_301801.1 CDS ML1094 NC_002677.1 1259132 1259965 R short chain alcohol dehydrogenase complement(1259132..1259965) Mycobacterium leprae TN 910181 NP_301802.2 CDS kgd NC_002677.1 1260028 1263744 R kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase complement(1260028..1263744) Mycobacterium leprae TN 910185 NP_301803.1 CDS ML1096 NC_002677.1 1263932 1264606 R hypothetical protein complement(1263932..1264606) Mycobacterium leprae TN 910187 NP_301804.1 CDS ML1098 NC_002677.1 1266648 1270106 R hypothetical protein complement(1266648..1270106) Mycobacterium leprae TN 910189 NP_301805.1 CDS ML1099 NC_002677.1 1270157 1270765 R lipoprotein complement(1270157..1270765) Mycobacterium leprae TN 910190 NP_301806.1 CDS ML1101 NC_002677.1 1272632 1273771 D acyltransferase 1272632..1273771 Mycobacterium leprae TN 910191 NP_301807.1 CDS ML1103 NC_002677.1 1276458 1277819 R oxidoreductase subunit complement(1276458..1277819) Mycobacterium leprae TN 910193 NP_301808.1 CDS ML1105 NC_002677.1 1279262 1279951 D hypothetical protein 1279262..1279951 Mycobacterium leprae TN 910195 NP_301809.1 CDS ML1106 NC_002677.1 1280426 1280767 D hypothetical protein 1280426..1280767 Mycobacterium leprae TN 910196 NP_301810.1 CDS ML1113 NC_002677.1 1287737 1289626 R ABC transporter ATP-binding protein complement(1287737..1289626) Mycobacterium leprae TN 910203 NP_301811.1 CDS ML1114 NC_002677.1 1289623 1291377 R ABC transporter ATP-binding protein complement(1289623..1291377) Mycobacterium leprae TN 910204 NP_301812.1 CDS ML1115 NC_002677.1 1291563 1292129 D lipoprotein 1291563..1292129 Mycobacterium leprae TN 910205 NP_301813.1 CDS ML1116 NC_002677.1 1292138 1292701 D lipoprotein 1292138..1292701 Mycobacterium leprae TN 910207 NP_301814.1 CDS ML1117 NC_002677.1 1292709 1293194 R hypothetical protein complement(1292709..1293194) Mycobacterium leprae TN 910209 NP_301815.1 CDS ML1119 NC_002677.1 1294763 1295914 D hypothetical protein 1294763..1295914 Mycobacterium leprae TN 910211 NP_301816.1 CDS ML1120 NC_002677.1 1295911 1298532 D hypothetical protein 1295911..1298532 Mycobacterium leprae TN 910212 NP_301817.1 CDS ML1121 NC_002677.1 1299720 1301393 R ABC transporter substrate-binding protein complement(1299720..1301393) Mycobacterium leprae TN 910213 NP_301818.1 CDS ML1122 NC_002677.1 1301390 1303219 R ABC transporter ATP-binding protein complement(1301390..1303219) Mycobacterium leprae TN 910208 NP_301819.1 CDS ML1123 NC_002677.1 1303216 1304115 R binding-protein dependent transport protein complement(1303216..1304115) Mycobacterium leprae TN 910214 NP_301820.1 CDS ML1124 NC_002677.1 1304112 1305089 R binding-protein dependent transport protein complement(1304112..1305089) Mycobacterium leprae TN 910216 NP_301821.1 CDS argS NC_002677.1 1316571 1318223 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1316571..1318223 Mycobacterium leprae TN 910221 NP_301822.1 CDS lysA NC_002677.1 1318220 1319638 D diaminopimelate decarboxylase 1318220..1319638 Mycobacterium leprae TN 910222 NP_301823.1 CDS hom NC_002677.1 1319642 1320967 D catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1319642..1320967 Mycobacterium leprae TN 910223 NP_301824.1 CDS thrC NC_002677.1 1320964 1322046 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1320964..1322046 Mycobacterium leprae TN 910224 NP_301825.1 CDS thrB NC_002677.1 1322114 1323061 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1322114..1323061 Mycobacterium leprae TN 910225 NP_301826.1 CDS rho NC_002677.1 1323331 1325163 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1323331..1325163 Mycobacterium leprae TN 910226 NP_301827.1 CDS rpmE NC_002677.1 1325474 1325728 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1325474..1325728 Mycobacterium leprae TN 910227 NP_301828.1 CDS prfA NC_002677.1 1325819 1326904 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1325819..1326904 Mycobacterium leprae TN 910228 NP_301829.1 CDS ML1135 NC_002677.1 1326901 1327767 D protoporphyrinogen oxidase 1326901..1327767 Mycobacterium leprae TN 910229 NP_301830.1 CDS ML1136 NC_002677.1 1327807 1328469 D hypothetical protein 1327807..1328469 Mycobacterium leprae TN 910230 NP_301831.1 CDS ML1137 NC_002677.1 1328500 1329699 D glycosyltransferase 1328500..1329699 Mycobacterium leprae TN 910220 NP_301832.1 CDS ML1138 NC_002677.1 1329962 1330423 D hypothetical protein 1329962..1330423 Mycobacterium leprae TN 910231 NP_301833.1 CDS atpB NC_002677.1 1330420 1331175 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1330420..1331175 Mycobacterium leprae TN 910232 NP_301834.1 CDS atpE NC_002677.1 1331271 1331516 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1331271..1331516 Mycobacterium leprae TN 910234 NP_301835.1 CDS atpF NC_002677.1 1331538 1332050 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1331538..1332050 Mycobacterium leprae TN 910233 NP_301836.1 CDS atpH NC_002677.1 1332056 1333396 D produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1332056..1333396 Mycobacterium leprae TN 910235 NP_301837.1 CDS atpA NC_002677.1 1333458 1335134 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1333458..1335134 Mycobacterium leprae TN 910237 NP_301838.1 CDS atpG NC_002677.1 1335152 1336048 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1335152..1336048 Mycobacterium leprae TN 910238 NP_301839.1 CDS atpD NC_002677.1 1336075 1337532 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1336075..1337532 Mycobacterium leprae TN 910239 NP_301840.1 CDS atpC NC_002677.1 1337565 1337930 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1337565..1337930 Mycobacterium leprae TN 910240 NP_301841.1 CDS ML1147 NC_002677.1 1337937 1338380 D hypothetical protein 1337937..1338380 Mycobacterium leprae TN 910241 NP_301842.1 CDS ML1148 NC_002677.1 1338519 1338674 R hypothetical protein complement(1338519..1338674) Mycobacterium leprae TN 910242 NP_301843.1 CDS ML1149 NC_002677.1 1338887 1339462 R hypothetical protein complement(1338887..1339462) Mycobacterium leprae TN 910243 NP_301844.1 CDS murA NC_002677.1 1339580 1340836 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1339580..1340836 Mycobacterium leprae TN 910244 NP_301845.1 CDS ogt NC_002677.1 1346360 1346857 R methylated-DNA--protein-cysteine methyltransferase complement(1346360..1346857) Mycobacterium leprae TN 910248 NP_301846.1 CDS ML1155 NC_002677.1 1351359 1352021 D hypothetical protein 1351359..1352021 Mycobacterium leprae TN 910253 NP_301847.1 CDS ML1157 NC_002677.1 1352353 1352820 R hypothetical protein complement(1352353..1352820) Mycobacterium leprae TN 910255 NP_301848.1 CDS fadA4 NC_002677.1 1352912 1354093 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 1352912..1354093 Mycobacterium leprae TN 910257 NP_301849.1 CDS ML1159 NC_002677.1 1354280 1355185 D hypothetical protein 1354280..1355185 Mycobacterium leprae TN 910259 NP_301850.1 CDS clpS NC_002677.1 1364612 1364938 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1364612..1364938 Mycobacterium leprae TN 910263 NP_301851.1 CDS ML1166 NC_002677.1 1364964 1365551 D hypothetical protein 1364964..1365551 Mycobacterium leprae TN 910264 NP_301852.1 CDS ML1167 NC_002677.1 1365551 1366639 D hydrolase 1365551..1366639 Mycobacterium leprae TN 910265 NP_301853.1 CDS ML1171 NC_002677.1 1368492 1369208 D hypothetical protein 1368492..1369208 Mycobacterium leprae TN 910269 NP_301854.1 CDS murI NC_002677.1 1369205 1370023 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1369205..1370023 Mycobacterium leprae TN 910270 NP_301855.1 CDS ML1173 NC_002677.1 1370096 1370878 D hypothetical protein 1370096..1370878 Mycobacterium leprae TN 910271 NP_301856.1 CDS rph NC_002677.1 1370968 1371747 D RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1370968..1371747 Mycobacterium leprae TN 910272 NP_301857.1 CDS ML1175 NC_002677.1 1371782 1372444 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1371782..1372444 Mycobacterium leprae TN 910273 NP_301858.1 CDS ML1176 NC_002677.1 1372485 1372844 R hypothetical protein complement(1372485..1372844) Mycobacterium leprae TN 910274 NP_301859.1 CDS ML1177 NC_002677.1 1372841 1373221 R lipoprotein complement(1372841..1373221) Mycobacterium leprae TN 910275 NP_301860.1 CDS ML1180 NC_002677.1 1380300 1380587 R hypothetical protein complement(1380300..1380587) Mycobacterium leprae TN 910279 NP_301861.1 CDS ML1181 NC_002677.1 1380639 1380941 R hypothetical protein complement(1380639..1380941) Mycobacterium leprae TN 910280 NP_301862.1 CDS ML1182 NC_002677.1 1381004 1382269 R PPE family protein complement(1381004..1382269) Mycobacterium leprae TN 910282 NP_301863.1 CDS ML1183 NC_002677.1 1382326 1382625 R hypothetical protein complement(1382326..1382625) Mycobacterium leprae TN 910285 NP_301864.1 CDS ML1186 NC_002677.1 1386776 1387078 R hypothetical protein complement(1386776..1387078) Mycobacterium leprae TN 910291 NP_301865.1 CDS ML1188 NC_002677.1 1390595 1390855 R hypothetical protein complement(1390595..1390855) Mycobacterium leprae TN 910289 NP_301866.1 CDS ML1189 NC_002677.1 1392493 1392876 R hypothetical protein complement(1392493..1392876) Mycobacterium leprae TN 910287 NP_301867.1 CDS ML1190 NC_002677.1 1395291 1396010 D hypothetical protein 1395291..1396010 Mycobacterium leprae TN 910286 NP_301868.1 CDS fas NC_002677.1 1396622 1405852 D fatty acid synthase 1396622..1405852 Mycobacterium leprae TN 910284 NP_301869.1 CDS acpS NC_002677.1 1405881 1406273 D Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1405881..1406273 Mycobacterium leprae TN 910293 NP_301870.1 CDS ML1193 NC_002677.1 1406363 1407691 D hypothetical protein 1406363..1407691 Mycobacterium leprae TN 910294 NP_301871.1 CDS ileS NC_002677.1 1410785 1413964 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1410785..1413964 Mycobacterium leprae TN 910297 NP_301872.1 CDS ansA NC_002677.1 1416022 1416954 R L-asparaginase/L-glutaminase complement(1416022..1416954) Mycobacterium leprae TN 910300 NP_301873.1 CDS lspA NC_002677.1 1417029 1417634 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1417029..1417634 Mycobacterium leprae TN 910324 NP_301874.1 CDS ML1200 NC_002677.1 1417753 1418679 D pseudouridine synthase 1417753..1418679 Mycobacterium leprae TN 910304 NP_301875.1 CDS dnaE NC_002677.1 1423014 1426547 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1423014..1426547 Mycobacterium leprae TN 910310 NP_301876.1 CDS ilvA NC_002677.1 1428251 1429534 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1428251..1429534 Mycobacterium leprae TN 910312 NP_301877.1 CDS ML1210 NC_002677.1 1431094 1431279 D hypothetical protein 1431094..1431279 Mycobacterium leprae TN 910313 NP_301878.1 CDS ML1213 NC_002677.1 1434679 1436880 R hypothetical protein complement(1434679..1436880) Mycobacterium leprae TN 910316 NP_301879.1 CDS ML1214 NC_002677.1 1437010 1437648 R p60-family protein complement(1437010..1437648) Mycobacterium leprae TN 910318 NP_301880.1 CDS bioA NC_002677.1 1438597 1439907 D catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1438597..1439907 Mycobacterium leprae TN 910321 NP_301881.1 CDS bioF NC_002677.1 1439914 1441071 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1439914..1441071 Mycobacterium leprae TN 910326 NP_301882.1 CDS bioD NC_002677.1 1441068 1441748 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1441068..1441748 Mycobacterium leprae TN 910322 NP_301883.1 CDS bioB NC_002677.1 1442502 1443539 D catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1442502..1443539 Mycobacterium leprae TN 910327 NP_301884.1 CDS ML1221 NC_002677.1 1443565 1443807 D hypothetical protein 1443565..1443807 Mycobacterium leprae TN 910329 NP_301885.1 CDS ML1222 NC_002677.1 1443804 1444400 D hypothetical protein 1443804..1444400 Mycobacterium leprae TN 910550 NP_301886.1 CDS ML1224 NC_002677.1 1445947 1446666 R hypothetical protein complement(1445947..1446666) Mycobacterium leprae TN 910331 NP_301887.1 CDS nadA NC_002677.1 1446713 1447771 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1446713..1447771 Mycobacterium leprae TN 910333 NP_301888.1 CDS nadB NC_002677.1 1447768 1449351 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1447768..1449351 Mycobacterium leprae TN 910334 NP_301889.1 CDS nadC NC_002677.1 1449348 1450208 D catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1449348..1450208 Mycobacterium leprae TN 910332 NP_301890.1 CDS pks3 NC_002677.1 1454299 1460655 D mycocerosic acid synthase (polyketide synthase) 1454299..1460655 Mycobacterium leprae TN 910330 NP_301891.1 CDS papA3 NC_002677.1 1460736 1462151 D hypothetical protein 1460736..1462151 Mycobacterium leprae TN 910337 NP_301892.1 CDS mmpL10 NC_002677.1 1462233 1465184 D large membrane protein 1462233..1465184 Mycobacterium leprae TN 910336 NP_301893.1 CDS ML1232 NC_002677.1 1465612 1466688 R hypothetical protein complement(1465612..1466688) Mycobacterium leprae TN 910335 NP_301894.1 CDS ML1233 NC_002677.1 1466853 1467545 R hypothetical protein complement(1466853..1467545) Mycobacterium leprae TN 910338 NP_301895.1 CDS ML1234 NC_002677.1 1467575 1469314 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1467575..1469314) Mycobacterium leprae TN 910341 NP_301896.1 CDS ML1241 NC_002677.1 1476551 1477435 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1476551..1477435 Mycobacterium leprae TN 910343 NP_301897.1 CDS ML1243 NC_002677.1 1482133 1482594 D hypothetical protein 1482133..1482594 Mycobacterium leprae TN 910350 NP_301898.1 CDS ML1244 NC_002677.1 1482817 1484292 D hypothetical protein 1482817..1484292 Mycobacterium leprae TN 910347 NP_301899.1 CDS ML1245 NC_002677.1 1484289 1486028 D transferase 1484289..1486028 Mycobacterium leprae TN 910344 NP_301900.1 CDS plsB NC_002677.1 1486025 1488352 D PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1486025..1488352 Mycobacterium leprae TN 910352 NP_301901.1 CDS ML1248 NC_002677.1 1489170 1490840 D ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 1489170..1490840 Mycobacterium leprae TN 910353 NP_301902.1 CDS ML1249 NC_002677.1 1490899 1495767 D hypothetical protein 1490899..1495767 Mycobacterium leprae TN 910359 NP_301903.1 CDS glbO NC_002677.1 1498151 1498537 R hemoglobin-like, oxygen carrier complement(1498151..1498537) Mycobacterium leprae TN 910362 NP_301904.1 CDS ML1254 NC_002677.1 1498706 1499353 D hypothetical protein 1498706..1499353 Mycobacterium leprae TN 910364 NP_301905.1 CDS ML1255 NC_002677.1 1499768 1500259 D hypothetical protein 1499768..1500259 Mycobacterium leprae TN 910367 NP_301906.1 CDS hisD NC_002677.1 1502297 1503646 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1502297..1503646 Mycobacterium leprae TN 910363 NP_301907.1 CDS hisC NC_002677.1 1503643 1504776 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1503643..1504776 Mycobacterium leprae TN 910368 NP_301908.1 CDS hisB NC_002677.1 1504773 1505405 D catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1504773..1505405 Mycobacterium leprae TN 910348 NP_301909.1 CDS hisH NC_002677.1 1505402 1506022 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1505402..1506022 Mycobacterium leprae TN 910371 NP_301910.1 CDS hisA NC_002677.1 1506032 1506769 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1506032..1506769 Mycobacterium leprae TN 910372 NP_301911.1 CDS hisF NC_002677.1 1507577 1508362 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1507577..1508362 Mycobacterium leprae TN 910374 NP_301912.1 CDS hisI NC_002677.1 1508359 1508706 D PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1508359..1508706 Mycobacterium leprae TN 910370 NP_301913.1 CDS ML1267 NC_002677.1 1510440 1511534 D antiporter 1510440..1511534 Mycobacterium leprae TN 910375 NP_301914.1 CDS trpE NC_002677.1 1512139 1513728 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1512139..1513728 Mycobacterium leprae TN 910378 NP_301915.1 CDS ML1270 NC_002677.1 1513725 1514522 D hypothetical protein 1513725..1514522 Mycobacterium leprae TN 910376 NP_301916.1 CDS trpC NC_002677.1 1514500 1515318 D involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 1514500..1515318 Mycobacterium leprae TN 910382 NP_301917.1 CDS trpB NC_002677.1 1515382 1516635 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1515382..1516635 Mycobacterium leprae TN 910381 NP_301918.1 CDS trpA NC_002677.1 1516632 1517444 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1516632..1517444 Mycobacterium leprae TN 910384 NP_301919.1 CDS ML1274 NC_002677.1 1517441 1518433 D transfers the N-acyl diglyceride moeity to the prostepctive N-terminalcysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1517441..1518433 Mycobacterium leprae TN 910385 NP_301920.1 CDS ML1275 NC_002677.1 1518430 1518666 D hypothetical protein 1518430..1518666 Mycobacterium leprae TN 910387 NP_301921.1 CDS ML1276 NC_002677.1 1519218 1519658 D hypothetical protein 1519218..1519658 Mycobacterium leprae TN 910388 NP_301922.1 CDS pykA NC_002677.1 1519741 1521159 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1519741..1521159 Mycobacterium leprae TN 910389 NP_301923.1 CDS tesB NC_002677.1 1521266 1522159 D acyl CoA thioesterase II 1521266..1522159 Mycobacterium leprae TN 910390 NP_301924.1 CDS ML1286 NC_002677.1 1531867 1532484 D two-component response regulatory protein 1531867..1532484 Mycobacterium leprae TN 910402 NP_301925.1 CDS ML1288 NC_002677.1 1536149 1537552 D hypothetical protein 1536149..1537552 Mycobacterium leprae TN 910406 NP_301926.1 CDS ML1289 NC_002677.1 1537584 1538114 D hypothetical protein 1537584..1538114 Mycobacterium leprae TN 910409 NP_301927.1 CDS ML1292 NC_002677.1 1540612 1540854 R hypothetical protein complement(1540612..1540854) Mycobacterium leprae TN 910404 NP_301928.1 CDS pyrD NC_002677.1 1543264 1544337 R catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 complement(1543264..1544337) Mycobacterium leprae TN 910412 NP_301929.1 CDS ML1294 NC_002677.1 1544355 1544609 R hypothetical protein complement(1544355..1544609) Mycobacterium leprae TN 910416 NP_301930.1 CDS ML1296 NC_002677.1 1545740 1546075 D hypothetical protein 1545740..1546075 Mycobacterium leprae TN 910417 NP_301931.1 CDS uppP NC_002677.1 1546116 1546964 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 1546116..1546964 Mycobacterium leprae TN 910413 NP_301932.1 CDS ML1298 NC_002677.1 1546961 1547713 D hypothetical protein 1546961..1547713 Mycobacterium leprae TN 910410 NP_301933.1 CDS ML1299 NC_002677.1 1547791 1548381 D hypothetical protein 1547791..1548381 Mycobacterium leprae TN 910415 NP_301934.1 CDS ML1300 NC_002677.1 1548392 1549180 D hypothetical protein 1548392..1549180 Mycobacterium leprae TN 910414 NP_301935.1 CDS ML1301 NC_002677.1 1549219 1550034 D inositol monophosphatase 1549219..1550034 Mycobacterium leprae TN 910420 NP_301936.1 CDS cysS NC_002677.1 1550230 1551384 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1550230..1551384 Mycobacterium leprae TN 910422 NP_301937.1 CDS ansP1 NC_002677.1 1552519 1554015 R L-asparagine permease complement(1552519..1554015) Mycobacterium leprae TN 910423 NP_301938.1 CDS ansP2 NC_002677.1 1554165 1555682 R L-asparagine permease complement(1554165..1555682) Mycobacterium leprae TN 910427 NP_301939.1 CDS ML1306 NC_002677.1 1555819 1556643 R hypothetical protein complement(1555819..1556643) Mycobacterium leprae TN 908155 NP_301940.1 CDS metH NC_002677.1 1556851 1560471 D 5-methyltetrahydrofolate--homocysteine methyltransferase 1556851..1560471 Mycobacterium leprae TN 910429 NP_301941.1 CDS hisE NC_002677.1 1561966 1562247 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 1561966..1562247 Mycobacterium leprae TN 910425 NP_301942.1 CDS hisG NC_002677.1 1562244 1563113 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1562244..1563113 Mycobacterium leprae TN 910435 NP_301943.1 CDS ML1312 NC_002677.1 1565153 1566037 R hypothetical protein complement(1565153..1566037) Mycobacterium leprae TN 910432 NP_301944.1 CDS ML1313 NC_002677.1 1566111 1566956 D hypothetical protein 1566111..1566956 Mycobacterium leprae TN 910431 NP_301945.1 CDS ML1314 NC_002677.1 1567070 1567363 R hypothetical protein complement(1567070..1567363) Mycobacterium leprae TN 910436 NP_301946.1 CDS ML1315 NC_002677.1 1567372 1567956 R lipoprotein complement(1567372..1567956) Mycobacterium leprae TN 910437 NP_301947.1 CDS ML1316 NC_002677.1 1568244 1570073 D ATPase AAA 1568244..1570073 Mycobacterium leprae TN 910441 NP_301948.1 CDS ML1320 NC_002677.1 1573917 1575461 D hypothetical protein 1573917..1575461 Mycobacterium leprae TN 910444 NP_301949.1 CDS ML1321 NC_002677.1 1575493 1575684 D hypothetical protein 1575493..1575684 Mycobacterium leprae TN 910443 NP_301950.1 CDS prcB NC_002677.1 1575681 1576556 D proteasome [beta]-type subunit 2 1575681..1576556 Mycobacterium leprae TN 910447 NP_301951.1 CDS prcA NC_002677.1 1576553 1577350 D proteasome [alpha]-type subunit 1 1576553..1577350 Mycobacterium leprae TN 910449 NP_301952.1 CDS ML1328 NC_002677.1 1579801 1581159 D DNA-binding protein 1579801..1581159 Mycobacterium leprae TN 910446 NP_301953.1 CDS ML1329 NC_002677.1 1581166 1582161 D hypothetical protein 1581166..1582161 Mycobacterium leprae TN 910438 NP_301954.1 CDS ML1330 NC_002677.1 1582158 1583132 D DNA-binding protein 1582158..1583132 Mycobacterium leprae TN 908553 NP_301955.2 CDS tatA NC_002677.1 1583205 1583471 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 1583205..1583471 Mycobacterium leprae TN 910454 NP_301956.1 CDS ML1332 NC_002677.1 1583610 1584470 D membrane transport protein 1583610..1584470 Mycobacterium leprae TN 910452 NP_301957.1 CDS helY NC_002677.1 1584495 1587257 D Ski2 subfamily helicase 1584495..1587257 Mycobacterium leprae TN 910456 NP_301958.1 CDS ML1334 NC_002677.1 1587322 1588140 D hypothetical protein 1587322..1588140 Mycobacterium leprae TN 910457 NP_301959.1 CDS ML1338 NC_002677.1 1595449 1596771 R hypothetical protein complement(1595449..1596771) Mycobacterium leprae TN 910464 NP_301960.1 CDS ML1339 NC_002677.1 1596791 1598368 R protease complement(1596791..1598368) Mycobacterium leprae TN 910462 NP_301961.1 CDS ML1340 NC_002677.1 1598382 1599188 R hypothetical protein complement(1598382..1599188) Mycobacterium leprae TN 910460 NP_301962.1 CDS ML1344 NC_002677.1 1602982 1603242 R hypothetical protein complement(1602982..1603242) Mycobacterium leprae TN 910474 NP_301963.1 CDS ML1346 NC_002677.1 1606113 1609121 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1606113..1609121 Mycobacterium leprae TN 910470 NP_301964.1 CDS ML1347 NC_002677.1 1609114 1609347 D hypothetical protein 1609114..1609347 Mycobacterium leprae TN 910476 NP_301965.1 CDS ML1351 NC_002677.1 1611520 1612164 D responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1611520..1612164 Mycobacterium leprae TN 910482 NP_301966.1 CDS tyrS NC_002677.1 1612175 1613455 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1612175..1613455 Mycobacterium leprae TN 910480 NP_301967.1 CDS ML1357 NC_002677.1 1617916 1618101 D hypothetical protein 1617916..1618101 Mycobacterium leprae TN 910488 NP_301968.1 CDS tlyA NC_002677.1 1618109 1618918 D cytotoxin/hemolysin 1618109..1618918 Mycobacterium leprae TN 910487 NP_301969.1 CDS ppnK NC_002677.1 1618915 1619850 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1618915..1619850 Mycobacterium leprae TN 910485 NP_301970.1 CDS recN NC_002677.1 1619874 1621637 D recombination and DNA repair 1619874..1621637 Mycobacterium leprae TN 910489 NP_301971.1 CDS ML1361 NC_002677.1 1621823 1623004 D hypothetical protein 1621823..1623004 Mycobacterium leprae TN 910490 NP_301972.1 CDS ML1362 NC_002677.1 1623026 1623979 D hypothetical protein 1623026..1623979 Mycobacterium leprae TN 910492 NP_301973.1 CDS pyrG NC_002677.1 1624152 1625924 D CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1624152..1625924 Mycobacterium leprae TN 910493 NP_301974.1 CDS xerD NC_002677.1 1626538 1627488 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1626538..1627488 Mycobacterium leprae TN 910455 NP_301975.1 CDS ML1367 NC_002677.1 1628029 1628892 D regulatory protein 1628029..1628892 Mycobacterium leprae TN 910494 NP_301976.1 CDS ML1368 NC_002677.1 1628889 1629695 D hypothetical protein 1628889..1629695 Mycobacterium leprae TN 910496 NP_301977.1 CDS ML1369 NC_002677.1 1629743 1630438 D hypothetical protein 1629743..1630438 Mycobacterium leprae TN 910491 NP_301978.1 CDS ML1370 NC_002677.1 1630435 1631208 D pseudouridine synthase 1630435..1631208 Mycobacterium leprae TN 910499 NP_301979.1 CDS cmk NC_002677.1 1631205 1631876 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1631205..1631876 Mycobacterium leprae TN 910501 NP_301980.1 CDS engA NC_002677.1 1631870 1633258 D synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1631870..1633258 Mycobacterium leprae TN 910500 NP_301981.1 CDS ML1380 NC_002677.1 1645070 1645633 D hypothetical protein 1645070..1645633 Mycobacterium leprae TN 910509 NP_301982.1 CDS polA NC_002677.1 1648220 1650955 R has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I complement(1648220..1650955) Mycobacterium leprae TN 910507 NP_301983.1 CDS rpsA NC_002677.1 1652728 1654173 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1652728..1654173 Mycobacterium leprae TN 910498 NP_301984.1 CDS coaE NC_002677.1 1654200 1655432 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1654200..1655432 Mycobacterium leprae TN 910513 NP_301985.1 CDS ML1384 NC_002677.1 1656225 1656563 D hypothetical protein 1656225..1656563 Mycobacterium leprae TN 910551 NP_301986.1 CDS uvrB NC_002677.1 1661665 1663761 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1661665..1663761 Mycobacterium leprae TN 910520 NP_301987.1 CDS ML1389 NC_002677.1 1665174 1666757 R hypothetical protein complement(1665174..1666757) Mycobacterium leprae TN 910522 NP_301988.1 CDS ML1390 NC_002677.1 1667049 1667492 D hypothetical protein 1667049..1667492 Mycobacterium leprae TN 910523 NP_301989.1 CDS ML1391 NC_002677.1 1667501 1668199 R hypothetical protein complement(1667501..1668199) Mycobacterium leprae TN 910524 NP_301990.1 CDS uvrA NC_002677.1 1668337 1671246 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1668337..1671246 Mycobacterium leprae TN 910525 NP_301991.1 CDS lysS NC_002677.1 1671923 1675042 R catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase complement(1671923..1675042) Mycobacterium leprae TN 910531 NP_301992.1 CDS infC NC_002677.1 1675807 1676364 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1675807..1676364 Mycobacterium leprae TN 910530 NP_301993.1 CDS rpmI NC_002677.1 1676415 1676609 D 50S ribosomal protein L35 1676415..1676609 Mycobacterium leprae TN 910528 NP_301994.1 CDS rplT NC_002677.1 1676663 1677052 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1676663..1677052 Mycobacterium leprae TN 910533 NP_301995.1 CDS tsnR NC_002677.1 1677107 1677886 D rRNA methyltransferase 1677107..1677886 Mycobacterium leprae TN 910536 NP_301996.1 CDS ML1399 NC_002677.1 1679214 1680188 D hypothetical protein 1679214..1680188 Mycobacterium leprae TN 910534 NP_301997.1 CDS pheS NC_002677.1 1681037 1682089 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1681037..1682089 Mycobacterium leprae TN 910539 NP_301998.1 CDS pheT NC_002677.1 1682086 1684596 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1682086..1684596 Mycobacterium leprae TN 910543 NP_301999.1 CDS argC NC_002677.1 1687672 1688715 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1687672..1688715 Mycobacterium leprae TN 910545 NP_302000.1 CDS argJ NC_002677.1 1688712 1689935 D bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 1688712..1689935 Mycobacterium leprae TN 910546 NP_302001.1 CDS argB NC_002677.1 1689932 1690837 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1689932..1690837 Mycobacterium leprae TN 910547 NP_302002.1 CDS argD NC_002677.1 1690889 1692103 D catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1690889..1692103 Mycobacterium leprae TN 910549 NP_302003.1 CDS argF NC_002677.1 1692135 1693097 D catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1692135..1693097 Mycobacterium leprae TN 910548 NP_302004.1 CDS argR NC_002677.1 1693100 1693603 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 1693100..1693603 Mycobacterium leprae TN 910553 NP_302005.1 CDS argG NC_002677.1 1693613 1694812 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1693613..1694812 Mycobacterium leprae TN 910554 NP_302006.1 CDS argH NC_002677.1 1694884 1696296 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1694884..1696296 Mycobacterium leprae TN 910552 NP_302007.1 CDS ML1417 NC_002677.1 1699648 1700454 D CDP-diacylglycerol pyrophosphatase 1699648..1700454 Mycobacterium leprae TN 910519 NP_302008.1 CDS ML1418 NC_002677.1 1700696 1701244 R hypothetical protein complement(1700696..1701244) Mycobacterium leprae TN 910556 NP_302009.1 CDS ML1419 NC_002677.1 1704354 1706045 R regulatory protein complement(1704354..1706045) Mycobacterium leprae TN 910557 NP_302010.1 CDS ML1420 NC_002677.1 1706391 1706744 D hypothetical protein 1706391..1706744 Mycobacterium leprae TN 910561 NP_302011.1 CDS ML1423 NC_002677.1 1710507 1711496 R hypothetical protein complement(1710507..1711496) Mycobacterium leprae TN 910560 NP_302012.1 CDS ML1424 NC_002677.1 1711566 1712636 R binding-protein-dependent transport protein complement(1711566..1712636) Mycobacterium leprae TN 910567 NP_302013.1 CDS ML1425 NC_002677.1 1712639 1713490 R ABC transporter inner membrane protein complement(1712639..1713490) Mycobacterium leprae TN 910568 NP_302014.1 CDS ML1426 NC_002677.1 1713477 1714436 R ABC transporter inner membrane protein complement(1713477..1714436) Mycobacterium leprae TN 909645 NP_302015.1 CDS ML1427 NC_002677.1 1714433 1715770 R lipoprotein ABC transporter complement(1714433..1715770) Mycobacterium leprae TN 910571 NP_302016.1 CDS ML1430 NC_002677.1 1716924 1717250 D hypothetical protein 1716924..1717250 Mycobacterium leprae TN 908141 NP_302017.1 CDS ML1439 NC_002677.1 1733347 1733682 D hypothetical protein 1733347..1733682 Mycobacterium leprae TN 909467 NP_302018.1 CDS ML1440 NC_002677.1 1733639 1734472 R glycosyl transferase family protein complement(1733639..1734472) Mycobacterium leprae TN 909468 NP_302019.1 CDS ML1441 NC_002677.1 1734469 1736403 R apolipoprotein N-acyltransferase complement(1734469..1736403) Mycobacterium leprae TN 909469 NP_302020.1 CDS ML1444 NC_002677.1 1738595 1739293 D dienelactone hydrolase 1738595..1739293 Mycobacterium leprae TN 909472 NP_302021.1 CDS ML1445 NC_002677.1 1739651 1739875 R hypothetical protein complement(1739651..1739875) Mycobacterium leprae TN 909473 NP_302022.1 CDS ML1446 NC_002677.1 1740098 1740484 R hypothetical protein complement(1740098..1740484) Mycobacterium leprae TN 909474 NP_302023.1 CDS ML1448 NC_002677.1 1740904 1741458 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 1740904..1741458 Mycobacterium leprae TN 909476 NP_302024.1 CDS ML1452 NC_002677.1 1746887 1747561 R phosphoglycerate mutase complement(1746887..1747561) Mycobacterium leprae TN 909480 NP_302025.1 CDS ML1453 NC_002677.1 1747561 1747950 R hypothetical protein complement(1747561..1747950) Mycobacterium leprae TN 909481 NP_302026.1 CDS nadD NC_002677.1 1747947 1748591 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1747947..1748591) Mycobacterium leprae TN 909482 NP_302027.1 CDS proA NC_002677.1 1751751 1752980 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(1751751..1752980) Mycobacterium leprae TN 909486 NP_302028.1 CDS nadE NC_002677.1 1759305 1761347 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1759305..1761347) Mycobacterium leprae TN 909491 NP_302029.1 CDS proB NC_002677.1 1761564 1762667 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(1761564..1762667) Mycobacterium leprae TN 909492 NP_302030.1 CDS obgE NC_002677.1 1762671 1764110 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1762671..1764110) Mycobacterium leprae TN 909493 NP_302031.1 CDS rpmA NC_002677.1 1764225 1764491 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(1764225..1764491) Mycobacterium leprae TN 909494 NP_302032.1 CDS rplU NC_002677.1 1764503 1764814 R 50S ribosomal protein L21 complement(1764503..1764814) Mycobacterium leprae TN 909495 NP_302033.1 CDS ML1468 NC_002677.1 1765041 1767815 R ribonuclease complement(1765041..1767815) Mycobacterium leprae TN 909496 NP_302034.1 CDS ndk NC_002677.1 1768158 1768568 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1768158..1768568) Mycobacterium leprae TN 909497 NP_302035.1 CDS ML1470 NC_002677.1 1768618 1768989 R hypothetical protein complement(1768618..1768989) Mycobacterium leprae TN 909498 NP_302036.1 CDS folC NC_002677.1 1768986 1770443 R folylpolyglutamate synthase complement(1768986..1770443) Mycobacterium leprae TN 909499 NP_302037.1 CDS valS NC_002677.1 1770440 1773100 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(1770440..1773100) Mycobacterium leprae TN 909500 NP_302038.1 CDS clpX NC_002677.1 1779773 1781053 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1779773..1781053) Mycobacterium leprae TN 909505 NP_302039.1 CDS mmuM NC_002677.1 1781326 1782207 D converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 1781326..1782207 Mycobacterium leprae TN 909506 NP_302040.1 CDS clpP2 NC_002677.1 1782204 1782848 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1782204..1782848) Mycobacterium leprae TN 909507 NP_302041.1 CDS clpP NC_002677.1 1782845 1783519 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1782845..1783519) Mycobacterium leprae TN 909508 NP_302042.1 CDS tig NC_002677.1 1783571 1784980 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(1783571..1784980) Mycobacterium leprae TN 909509 NP_302043.1 CDS ML1484 NC_002677.1 1787386 1787874 R catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B complement(1787386..1787874) Mycobacterium leprae TN 909514 NP_302044.1 CDS ML1485 NC_002677.1 1787915 1788538 R hypothetical protein complement(1787915..1788538) Mycobacterium leprae TN 909515 NP_302045.1 CDS ML1486 NC_002677.1 1788670 1791258 D aminopeptidase 1788670..1791258 Mycobacterium leprae TN 909516 NP_302046.1 CDS ML1488 NC_002677.1 1792958 1794061 R catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase complement(1792958..1794061) Mycobacterium leprae TN 909520 NP_302047.1 CDS fdxA NC_002677.1 1794099 1794425 R ferredoxin complement(1794099..1794425) Mycobacterium leprae TN 909521 NP_302048.1 CDS fbiC NC_002677.1 1797612 1800203 R 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase complement(1797612..1800203) Mycobacterium leprae TN 909524 NP_302049.1 CDS ML1494 NC_002677.1 1801370 1801723 R hypothetical protein complement(1801370..1801723) Mycobacterium leprae TN 909526 NP_302050.1 CDS ML1495 NC_002677.1 1801888 1802814 R hypothetical protein complement(1801888..1802814) Mycobacterium leprae TN 909527 NP_302051.1 CDS ML1497 NC_002677.1 1803621 1805474 R hypothetical protein complement(1803621..1805474) Mycobacterium leprae TN 909529 NP_302052.1 CDS ML1498 NC_002677.1 1805541 1807427 R GTP-binding, protein elongation factor complement(1805541..1807427) Mycobacterium leprae TN 909530 NP_302053.1 CDS phhB NC_002677.1 1815091 1815375 D 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 1815091..1815375 Mycobacterium leprae TN 909536 NP_302054.1 CDS pimE NC_002677.1 1815362 1816654 R involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase complement(1815362..1816654) Mycobacterium leprae TN 909537 NP_302055.1 CDS ML1505 NC_002677.1 1816758 1817306 D hypothetical protein 1816758..1817306 Mycobacterium leprae TN 909538 NP_302056.1 CDS ML1506 NC_002677.1 1817334 1818380 D hypothetical protein 1817334..1818380 Mycobacterium leprae TN 909539 NP_302057.1 CDS ML1508 NC_002677.1 1819557 1820048 R hypothetical protein complement(1819557..1820048) Mycobacterium leprae TN 909541 NP_302058.1 CDS ML1511 NC_002677.1 1821243 1821956 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1821243..1821956 Mycobacterium leprae TN 909544 NP_302059.1 CDS ML1512 NC_002677.1 1822931 1824607 R hypothetical protein complement(1822931..1824607) Mycobacterium leprae TN 909545 NP_302060.1 CDS dapA NC_002677.1 1824627 1825529 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(1824627..1825529) Mycobacterium leprae TN 909546 NP_302061.1 CDS thyX NC_002677.1 1825645 1826409 R flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase complement(1825645..1826409) Mycobacterium leprae TN 909547 NP_302062.1 CDS ML1517 NC_002677.1 1831393 1831674 R hypothetical protein complement(1831393..1831674) Mycobacterium leprae TN 909550 NP_302063.1 CDS folA NC_002677.1 1832476 1832973 R dihydrofolate reductase complement(1832476..1832973) Mycobacterium leprae TN 909551 NP_302064.1 CDS thyA NC_002677.1 1833026 1833826 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(1833026..1833826) Mycobacterium leprae TN 909552 NP_302065.1 CDS ML1523 NC_002677.1 1837820 1838110 R hypothetical protein complement(1837820..1838110) Mycobacterium leprae TN 909556 NP_302066.1 CDS ML1525 NC_002677.1 1840011 1840466 R hypothetical protein complement(1840011..1840466) Mycobacterium leprae TN 909558 NP_302067.1 CDS ML1526 NC_002677.1 1840474 1840956 R hypothetical protein complement(1840474..1840956) Mycobacterium leprae TN 909559 NP_302068.1 CDS ald NC_002677.1 1846966 1848081 D L-alanine dehydrogenase 1846966..1848081 Mycobacterium leprae TN 909565 NP_302069.1 CDS ML1536 NC_002677.1 1851730 1853562 R hypothetical protein complement(1851730..1853562) Mycobacterium leprae TN 909569 NP_302070.1 CDS ML1537 NC_002677.1 1853559 1854764 R hypothetical protein complement(1853559..1854764) Mycobacterium leprae TN 909570 NP_302071.1 CDS ML1538 NC_002677.1 1854785 1856488 R protease complement(1854785..1856488) Mycobacterium leprae TN 909571 NP_302072.1 CDS ML1539 NC_002677.1 1856520 1858031 R hypothetical protein complement(1856520..1858031) Mycobacterium leprae TN 909577 NP_302073.1 CDS ML1540 NC_002677.1 1858295 1859197 R hypothetical protein complement(1858295..1859197) Mycobacterium leprae TN 909597 NP_302074.1 CDS ML1543 NC_002677.1 1862215 1866252 R SpoIIIE-family membrane protein complement(1862215..1866252) Mycobacterium leprae TN 909600 NP_302075.1 CDS ML1544 NC_002677.1 1866369 1867889 R hypothetical protein complement(1866369..1867889) Mycobacterium leprae TN 909601 NP_302076.1 CDS truB NC_002677.1 1870999 1871961 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1870999..1871961) Mycobacterium leprae TN 909603 NP_302077.1 CDS ML1547 NC_002677.1 1871958 1872641 R hypothetical protein complement(1871958..1872641) Mycobacterium leprae TN 909604 NP_302078.1 CDS ML1548 NC_002677.1 1872638 1873603 R hypothetical protein complement(1872638..1873603) Mycobacterium leprae TN 909605 NP_302079.1 CDS proS NC_002677.1 1877242 1878684 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1877242..1878684 Mycobacterium leprae TN 909610 NP_302080.1 CDS rbfA NC_002677.1 1879669 1880163 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(1879669..1880163) Mycobacterium leprae TN 909612 NP_302081.1 CDS infB NC_002677.1 1880177 1882951 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(1880177..1882951) Mycobacterium leprae TN 909613 NP_302082.1 CDS ML1557 NC_002677.1 1883016 1883336 R hypothetical protein complement(1883016..1883336) Mycobacterium leprae TN 909614 NP_302083.1 CDS nusA NC_002677.1 1883536 1884579 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(1883536..1884579) Mycobacterium leprae TN 909615 NP_302084.1 CDS ML1560 NC_002677.1 1885239 1885775 D hypothetical protein 1885239..1885775 Mycobacterium leprae TN 909619 NP_302085.1 CDS ML1561 NC_002677.1 1885772 1886269 D hypothetical protein 1885772..1886269 Mycobacterium leprae TN 909618 NP_302086.1 CDS ML1562 NC_002677.1 1886294 1887898 R transmembrane efflux protein complement(1886294..1887898) Mycobacterium leprae TN 910126 NP_302087.1 CDS ML1572 NC_002677.1 1898124 1898522 D hypothetical protein 1898124..1898522 Mycobacterium leprae TN 909636 NP_302088.1 CDS ML1573 NC_002677.1 1898983 1899732 R amidotransferase complement(1898983..1899732) Mycobacterium leprae TN 909634 NP_302089.1 CDS ML1575 NC_002677.1 1900169 1900462 R hypothetical protein complement(1900169..1900462) Mycobacterium leprae TN 909631 NP_302090.1 CDS mapB NC_002677.1 1900886 1901743 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase complement(1900886..1901743) Mycobacterium leprae TN 909624 NP_302091.1 CDS ML1577 NC_002677.1 1901935 1903761 R penicillin binding protein complement(1901935..1903761) Mycobacterium leprae TN 909637 NP_302092.1 CDS ispG NC_002677.1 1905761 1906939 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(1905761..1906939) Mycobacterium leprae TN 909640 NP_302093.1 CDS ML1582 NC_002677.1 1906992 1908206 R hypothetical protein complement(1906992..1908206) Mycobacterium leprae TN 909642 NP_302094.1 CDS ML1583 NC_002677.1 1908215 1909435 R catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase complement(1908215..1909435) Mycobacterium leprae TN 909644 NP_302095.1 CDS ML1584 NC_002677.1 1909590 1909844 D hypothetical protein 1909590..1909844 Mycobacterium leprae TN 909643 NP_302096.1 CDS ML1589 NC_002677.1 1913897 1914835 R The C-terminus of this protein is; phosphatidate cytidylyltransferase complement(1913897..1914835) Mycobacterium leprae TN 909784 NP_302097.1 CDS frr NC_002677.1 1914867 1915424 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(1914867..1915424) Mycobacterium leprae TN 909787 NP_302098.1 CDS pyrH NC_002677.1 1915483 1916322 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(1915483..1916322) Mycobacterium leprae TN 909788 NP_302099.1 CDS ML1596 NC_002677.1 1920913 1922319 R catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase complement(1920913..1922319) Mycobacterium leprae TN 908490 NP_302100.1 CDS tsf NC_002677.1 1922355 1923185 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(1922355..1923185) Mycobacterium leprae TN 909802 NP_302101.1 CDS rpsB NC_002677.1 1923187 1924020 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(1923187..1924020) Mycobacterium leprae TN 909804 NP_302102.1 CDS xerC NC_002677.1 1924844 1925737 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(1924844..1925737) Mycobacterium leprae TN 909806 NP_302103.1 CDS ML1601 NC_002677.1 1926754 1927119 R hypothetical protein complement(1926754..1927119) Mycobacterium leprae TN 908176 NP_302104.1 CDS ML1602 NC_002677.1 1927803 1928123 R hypothetical protein complement(1927803..1928123) Mycobacterium leprae TN 910909 NP_302105.1 CDS ML1603 NC_002677.1 1928376 1928636 R hypothetical protein complement(1928376..1928636) Mycobacterium leprae TN 908146 NP_302106.1 CDS ML1604 NC_002677.1 1928846 1929235 R hypothetical protein complement(1928846..1929235) Mycobacterium leprae TN 909830 NP_302107.1 CDS ML1605 NC_002677.1 1931206 1931406 D hypothetical protein 1931206..1931406 Mycobacterium leprae TN 909807 NP_302108.1 CDS ML1607 NC_002677.1 1932700 1932990 R hypothetical protein complement(1932700..1932990) Mycobacterium leprae TN 909331 NP_302109.1 CDS ML1610 NC_002677.1 1935020 1935325 R hypothetical protein complement(1935020..1935325) Mycobacterium leprae TN 909809 NP_302110.1 CDS rnhB NC_002677.1 1935438 1936160 R RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII complement(1935438..1936160) Mycobacterium leprae TN 909811 NP_302111.1 CDS ML1612 NC_002677.1 1936163 1937032 R ignal peptidase I complement(1936163..1937032) Mycobacterium leprae TN 909308 NP_302112.1 CDS rplS NC_002677.1 1937112 1937453 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1937112..1937453) Mycobacterium leprae TN 909816 NP_302113.1 CDS trmD NC_002677.1 1938739 1939455 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(1938739..1939455) Mycobacterium leprae TN 909818 NP_302114.1 CDS rimM NC_002677.1 1939452 1939991 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(1939452..1939991) Mycobacterium leprae TN 909820 NP_302115.1 CDS ML1617 NC_002677.1 1939996 1940238 R hypothetical protein complement(1939996..1940238) Mycobacterium leprae TN 909822 NP_302116.1 CDS rpsP NC_002677.1 1940263 1940745 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(1940263..1940745) Mycobacterium leprae TN 909823 NP_302117.1 CDS ffh NC_002677.1 1943801 1945366 R signal recognition particle protein complement(1943801..1945366) Mycobacterium leprae TN 909829 NP_302118.1 CDS htpG NC_002677.1 1945505 1947475 D molecular chaperone; heat shock protein 90 1945505..1947475 Mycobacterium leprae TN 909831 NP_302119.1 CDS ML1624 NC_002677.1 1947637 1949427 D hypothetical protein 1947637..1949427 Mycobacterium leprae TN 910814 NP_302120.1 CDS ML1628 NC_002677.1 1953448 1954740 R SRP family GTP-binding protein complement(1953448..1954740) Mycobacterium leprae TN 910809 NP_302121.1 CDS smc NC_002677.1 1954854 1958465 R cell division protein complement(1954854..1958465) Mycobacterium leprae TN 909835 NP_302122.1 CDS glnE NC_002677.1 1959885 1962899 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(1959885..1962899) Mycobacterium leprae TN 909837 NP_302123.1 CDS glnA2 NC_002677.1 1962930 1964276 R glutamine synthase class II complement(1962930..1964276) Mycobacterium leprae TN 909840 NP_302124.1 CDS ML1632 NC_002677.1 1964373 1965908 R hydrolase complement(1964373..1965908) Mycobacterium leprae TN 909841 NP_302125.1 CDS ML1633 NC_002677.1 1965983 1967590 R hydrolase complement(1965983..1967590) Mycobacterium leprae TN 909843 NP_302126.1 CDS panB NC_002677.1 1969128 1969988 D catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1969128..1969988 Mycobacterium leprae TN 909845 NP_302127.1 CDS ML1637 NC_002677.1 1974010 1975125 R bifunctional RNase H/acid phosphatase complement(1974010..1975125) Mycobacterium leprae TN 909850 NP_302128.1 CDS ML1638 NC_002677.1 1975122 1975820 R hypothetical protein complement(1975122..1975820) Mycobacterium leprae TN 909867 NP_302129.1 CDS ML1639 NC_002677.1 1975866 1977023 R hypothetical protein complement(1975866..1977023) Mycobacterium leprae TN 909868 NP_302130.1 CDS ML1644 NC_002677.1 1978961 1979773 D hypothetical protein 1978961..1979773 Mycobacterium leprae TN 909938 NP_302131.1 CDS ML1649 NC_002677.1 1987829 1988251 R hypothetical protein complement(1987829..1988251) Mycobacterium leprae TN 909967 NP_302132.1 CDS aceE NC_002677.1 1989164 1991974 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1989164..1991974 Mycobacterium leprae TN 909973 NP_302133.1 CDS ML1652 NC_002677.1 1992060 1993304 D hypothetical protein 1992060..1993304 Mycobacterium leprae TN 909979 NP_302134.1 CDS fabD NC_002677.1 1993515 1994429 D ACP S-malonyltransferase 1993515..1994429 Mycobacterium leprae TN 909982 NP_302135.1 CDS acpP NC_002677.1 1994529 1994876 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1994529..1994876 Mycobacterium leprae TN 909992 NP_302136.1 CDS kasA NC_002677.1 1994873 1996123 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1994873..1996123 Mycobacterium leprae TN 909994 NP_302137.1 CDS kasB NC_002677.1 1996136 1997413 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1996136..1997413 Mycobacterium leprae TN 910002 NP_302138.1 CDS ML1657 NC_002677.1 1997444 1998865 D acetyl/propionyl CoA carboxylase subunit beta 1997444..1998865 Mycobacterium leprae TN 910005 NP_302139.1 CDS fpg NC_002677.1 1999991 2000839 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(1999991..2000839) Mycobacterium leprae TN 910013 NP_302140.1 CDS rnc NC_002677.1 2000894 2001610 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2000894..2001610) Mycobacterium leprae TN 910019 NP_302141.1 CDS ML1660 NC_002677.1 2001607 2002260 R hypothetical protein complement(2001607..2002260) Mycobacterium leprae TN 910024 NP_302142.1 CDS ML1661 NC_002677.1 2002294 2003037 R hypothetical protein complement(2002294..2003037) Mycobacterium leprae TN 910026 NP_302143.1 CDS coaD NC_002677.1 2005132 2005605 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(2005132..2005605) Mycobacterium leprae TN 910028 NP_302144.1 CDS ML1664 NC_002677.1 2005637 2006110 R hypothetical protein complement(2005637..2006110) Mycobacterium leprae TN 910029 NP_302145.1 CDS ML1666 NC_002677.1 2009601 2010245 R hypothetical protein complement(2009601..2010245) Mycobacterium leprae TN 910032 NP_302146.1 CDS ML1667 NC_002677.1 2010254 2011048 R hypothetical protein complement(2010254..2011048) Mycobacterium leprae TN 910033 NP_302147.1 CDS ML1669 NC_002677.1 2013056 2013904 D aldo/keto reductase 2013056..2013904 Mycobacterium leprae TN 910035 NP_302148.1 CDS recG NC_002677.1 2014723 2016954 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(2014723..2016954) Mycobacterium leprae TN 910037 NP_302149.1 CDS ung NC_002677.1 2019277 2019960 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(2019277..2019960) Mycobacterium leprae TN 910041 NP_302150.1 CDS thiL NC_002677.1 2020074 2021051 R catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase complement(2020074..2021051) Mycobacterium leprae TN 910042 NP_302151.1 CDS ML1677 NC_002677.1 2021235 2021810 D hypothetical protein 2021235..2021810 Mycobacterium leprae TN 910043 NP_302152.1 CDS ddl NC_002677.1 2021819 2022973 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(2021819..2022973) Mycobacterium leprae TN 910044 NP_302153.1 CDS gpsA NC_002677.1 2023085 2024140 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(2023085..2024140) Mycobacterium leprae TN 910045 NP_302154.1 CDS ML1680 NC_002677.1 2024681 2025331 D hypothetical protein 2024681..2025331 Mycobacterium leprae TN 910046 NP_302155.1 CDS ML1681 NC_002677.1 2025415 2027634 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2025415..2027634 Mycobacterium leprae TN 910048 NP_302156.1 CDS ML1682 NC_002677.1 2027713 2028648 D hypothetical protein 2027713..2028648 Mycobacterium leprae TN 910049 NP_302157.1 CDS ML1683 NC_002677.1 2028717 2029319 R histone-like protein complement(2028717..2029319) Mycobacterium leprae TN 910050 NP_302158.1 CDS leuD NC_002677.1 2029533 2030129 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(2029533..2030129) Mycobacterium leprae TN 910051 NP_302159.1 CDS leuC NC_002677.1 2030172 2031629 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(2030172..2031629) Mycobacterium leprae TN 910053 NP_302160.1 CDS gltX NC_002677.1 2033584 2035092 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2033584..2035092) Mycobacterium leprae TN 910058 NP_302161.1 CDS ML1689 NC_002677.1 2035089 2035817 R hydrolase complement(2035089..2035817) Mycobacterium leprae TN 910059 NP_302162.1 CDS leuB NC_002677.1 2037155 2038165 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(2037155..2038165) Mycobacterium leprae TN 910061 NP_302163.1 CDS serA NC_002677.1 2038215 2039801 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(2038215..2039801) Mycobacterium leprae TN 910062 NP_302164.1 CDS ilvC NC_002677.1 2042720 2043721 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(2042720..2043721) Mycobacterium leprae TN 910812 NP_302165.1 CDS ilvH NC_002677.1 2043774 2044283 R with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit complement(2043774..2044283) Mycobacterium leprae TN 910799 NP_302166.1 CDS ilvB NC_002677.1 2044335 2046212 R acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit complement(2044335..2046212) Mycobacterium leprae TN 910798 NP_302167.1 CDS ML1698 NC_002677.1 2046984 2047817 R hypothetical protein complement(2046984..2047817) Mycobacterium leprae TN 910796 NP_302168.1 CDS ML1699 NC_002677.1 2048060 2049178 D lipoprotein 2048060..2049178 Mycobacterium leprae TN 910795 NP_302169.1 CDS gatB NC_002677.1 2050120 2051649 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(2050120..2051649) Mycobacterium leprae TN 910794 NP_302170.1 CDS pfkA NC_002677.1 2051998 2053029 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(2051998..2053029) Mycobacterium leprae TN 910793 NP_302171.1 CDS gatA NC_002677.1 2053117 2054610 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(2053117..2054610) Mycobacterium leprae TN 910792 NP_302172.1 CDS gatC NC_002677.1 2054607 2054906 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(2054607..2054906) Mycobacterium leprae TN 910791 NP_302173.1 CDS ML1704 NC_002677.1 2055043 2055741 D hypothetical protein 2055043..2055741 Mycobacterium leprae TN 910790 NP_302174.1 CDS ligA NC_002677.1 2055744 2057828 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2055744..2057828) Mycobacterium leprae TN 910789 NP_302175.1 CDS ML1706 NC_002677.1 2057887 2058900 R hypothetical protein complement(2057887..2058900) Mycobacterium leprae TN 910788 NP_302176.1 CDS mnmA NC_002677.1 2059816 2060892 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(2059816..2060892) Mycobacterium leprae TN 910787 NP_302177.1 CDS ML1708 NC_002677.1 2060889 2062121 R aminotransferase complement(2060889..2062121) Mycobacterium leprae TN 910786 NP_302178.1 CDS eftA NC_002677.1 2064075 2065031 R electron transfer flavoprotein [alpha] subunit complement(2064075..2065031) Mycobacterium leprae TN 910783 NP_302179.1 CDS eftB NC_002677.1 2065080 2065880 R electron transfer flavoprotein [beta] subunit complement(2065080..2065880) Mycobacterium leprae TN 910782 NP_302180.1 CDS ML1713 NC_002677.1 2066108 2066950 D hypothetical protein 2066108..2066950 Mycobacterium leprae TN 910781 NP_302181.1 CDS ML1714 NC_002677.1 2066947 2068515 D hypothetical protein 2066947..2068515 Mycobacterium leprae TN 910780 NP_302182.1 CDS ML1715 NC_002677.1 2068541 2069857 D transferase 2068541..2069857 Mycobacterium leprae TN 910779 NP_302183.1 CDS ML1717 NC_002677.1 2071353 2071646 R hypothetical protein complement(2071353..2071646) Mycobacterium leprae TN 910777 NP_302184.1 CDS ML1719 NC_002677.1 2074924 2075661 R The C-terminus of this protein is; hypothetical protein complement(2074924..2075661) Mycobacterium leprae TN 910775 NP_302185.1 CDS ML1720 NC_002677.1 2076101 2077195 D hypothetical protein 2076101..2077195 Mycobacterium leprae TN 910774 NP_302186.1 CDS ML1723 NC_002677.1 2079775 2080758 R hypothetical protein complement(2079775..2080758) Mycobacterium leprae TN 910770 NP_302187.1 CDS ML1724 NC_002677.1 2080791 2081549 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2080791..2081549) Mycobacterium leprae TN 910769 NP_302188.1 CDS ML1726 NC_002677.1 2082421 2083338 R ABC transporter protein, ATP-binding component complement(2082421..2083338) Mycobacterium leprae TN 910767 NP_302189.1 CDS ML1727 NC_002677.1 2083348 2084583 R phosphoserine phosphatase complement(2083348..2084583) Mycobacterium leprae TN 910766 NP_302190.1 CDS ML1728 NC_002677.1 2084623 2086347 R cytochrome C oxidase, polypeptide I complement(2084623..2086347) Mycobacterium leprae TN 910765 NP_302191.1 CDS fecB NC_002677.1 2086562 2087656 D FeIII-dicitrate transporter lipoprotein 2086562..2087656 Mycobacterium leprae TN 910764 NP_302192.1 CDS adhA NC_002677.1 2087916 2089004 D alcohol dehydrogenase 2087916..2089004 Mycobacterium leprae TN 910763 NP_302193.1 CDS nrdF NC_002677.1 2090613 2091590 R B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta complement(2090613..2091590) Mycobacterium leprae TN 910762 NP_302194.1 CDS ML1733 NC_002677.1 2093450 2094277 R TetR family transcriptional regulator complement(2093450..2094277) Mycobacterium leprae TN 910760 NP_302195.1 CDS nrdE NC_002677.1 2094324 2096405 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(2094324..2096405) Mycobacterium leprae TN 910759 NP_302196.1 CDS nrdI NC_002677.1 2096490 2096906 R in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein complement(2096490..2096906) Mycobacterium leprae TN 910758 NP_302197.1 CDS nrdH NC_002677.1 2096935 2097177 R glutaredoxin electron transport component of NrdEF complement(2096935..2097177) Mycobacterium leprae TN 910757 NP_302198.1 CDS ML1740 NC_002677.1 2099981 2100919 R short chain dehydrogenase complement(2099981..2100919) Mycobacterium leprae TN 910753 NP_302199.1 CDS ML1750 NC_002677.1 2115121 2116992 R The C-terminus of this protein is; hypothetical protein complement(2115121..2116992) Mycobacterium leprae TN 910743 NP_302200.1 CDS ML1751 NC_002677.1 2117010 2119175 R hypothetical protein complement(2117010..2119175) Mycobacterium leprae TN 910742 NP_302201.1 CDS ML1752 NC_002677.1 2121319 2122227 R hypothetical protein complement(2121319..2122227) Mycobacterium leprae TN 910741 NP_302202.1 CDS ML1753 NC_002677.1 2123768 2127088 R transcriptional regulator complement(2123768..2127088) Mycobacterium leprae TN 910740 NP_302203.1 CDS sdaA NC_002677.1 2129657 2131033 R L-serine dehydratase complement(2129657..2131033) Mycobacterium leprae TN 910738 NP_302204.1 CDS ML1756 NC_002677.1 2131291 2131614 D multidrug resistance protein 2131291..2131614 Mycobacterium leprae TN 910737 NP_302205.1 CDS ML1761 NC_002677.1 2136027 2136371 R hypothetical protein complement(2136027..2136371) Mycobacterium leprae TN 910730 NP_302206.1 CDS ML1763 NC_002677.1 2138763 2138978 D hypothetical protein 2138763..2138978 Mycobacterium leprae TN 910728 NP_302207.1 CDS uspA NC_002677.1 2143276 2144262 D sugar transport integral membrane protein 2143276..2144262 Mycobacterium leprae TN 910723 NP_302208.1 CDS uspE NC_002677.1 2144249 2145073 D sugar transport integral membrane protein 2144249..2145073 Mycobacterium leprae TN 910722 NP_302209.1 CDS uspC NC_002677.1 2145165 2146505 D sugar transport periplasmic binding protein 2145165..2146505 Mycobacterium leprae TN 910721 NP_302210.1 CDS ML1781 NC_002677.1 2157673 2158185 R hypothetical protein complement(2157673..2158185) Mycobacterium leprae TN 910710 NP_302211.1 CDS ML1782 NC_002677.1 2158324 2159145 R hypothetical protein complement(2158324..2159145) Mycobacterium leprae TN 910709 NP_302212.1 CDS ML1783 NC_002677.1 2159145 2160113 R transcriptional regulator complement(2159145..2160113) Mycobacterium leprae TN 910708 NP_302213.1 CDS adhE2 NC_002677.1 2160275 2161360 D alcohol dehydrogenase 2160275..2161360 Mycobacterium leprae TN 910707 NP_302214.1 CDS ML1788 NC_002677.1 2163355 2163819 R hypothetical protein complement(2163355..2163819) Mycobacterium leprae TN 910703 NP_302215.1 CDS ML1791 NC_002677.1 2165620 2166063 R hypothetical protein complement(2165620..2166063) Mycobacterium leprae TN 910700 NP_302216.1 CDS ML1793 NC_002677.1 2169013 2169318 D hypothetical protein 2169013..2169318 Mycobacterium leprae TN 910698 NP_302217.1 CDS ML1794 NC_002677.1 2171512 2172720 D aminotransferase 2171512..2172720 Mycobacterium leprae TN 910697 NP_302218.1 CDS hsp18 NC_002677.1 2174297 2174743 D hypothetical protein 2174297..2174743 Mycobacterium leprae TN 910696 NP_302219.1 CDS ML1796 NC_002677.1 2175302 2175715 D hypothetical protein 2175302..2175715 Mycobacterium leprae TN 910695 NP_302220.1 CDS ML1798 NC_002677.1 2176919 2177902 R functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase complement(2176919..2177902) Mycobacterium leprae TN 910693 NP_302221.1 CDS mutB NC_002677.1 2177903 2180179 R MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase complement(2177903..2180179) Mycobacterium leprae TN 910692 NP_302222.1 CDS mutA NC_002677.1 2180185 2182095 R methylmalonyl-CoA mutase, [beta] subunit complement(2180185..2182095) Mycobacterium leprae TN 910691 NP_302223.1 CDS ML1802 NC_002677.1 2183195 2184319 R hypothetical protein complement(2183195..2184319) Mycobacterium leprae TN 910689 NP_302224.1 CDS ML1803 NC_002677.1 2184356 2184787 R hypothetical protein complement(2184356..2184787) Mycobacterium leprae TN 910688 NP_302225.1 CDS ML1804 NC_002677.1 2184845 2185741 D hypothetical protein 2184845..2185741 Mycobacterium leprae TN 910687 NP_302226.1 CDS hemH NC_002677.1 2185778 2186788 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(2185778..2186788) Mycobacterium leprae TN 910686 NP_302227.1 CDS inhA NC_002677.1 2186795 2187604 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase complement(2186795..2187604) Mycobacterium leprae TN 910685 NP_302228.1 CDS fabG1 NC_002677.1 2187634 2188395 R 3-oxoacyl-ACP reductase complement(2187634..2188395) Mycobacterium leprae TN 910684 NP_302229.1 CDS ML1808 NC_002677.1 2188468 2189475 R hypothetical protein complement(2188468..2189475) Mycobacterium leprae TN 910683 NP_302230.1 CDS ML1809 NC_002677.1 2189519 2190481 R hypothetical protein complement(2189519..2190481) Mycobacterium leprae TN 910682 NP_302231.1 CDS moxR NC_002677.1 2190478 2191611 R MoxR-like protein complement(2190478..2191611) Mycobacterium leprae TN 910681 NP_302232.1 CDS ML1811 NC_002677.1 2191846 2192571 R hypothetical protein complement(2191846..2192571) Mycobacterium leprae TN 910680 NP_302233.1 CDS ML1812 NC_002677.1 2192598 2194037 R hypothetical protein complement(2192598..2194037) Mycobacterium leprae TN 910679 NP_302234.1 CDS ML1813 NC_002677.1 2194277 2194849 R hypothetical protein complement(2194277..2194849) Mycobacterium leprae TN 910678 NP_302235.1 CDS acn NC_002677.1 2195132 2197966 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 2195132..2197966 Mycobacterium leprae TN 910677 NP_302236.1 CDS ML1816 NC_002677.1 2198955 2200592 R ABC transporter ATP-binding protein complement(2198955..2200592) Mycobacterium leprae TN 910675 NP_302237.1 CDS trxB NC_002677.1 2201521 2201913 R thioredoxin complement(2201521..2201913) Mycobacterium leprae TN 910673 NP_302238.1 CDS ML1821 NC_002677.1 2204726 2205079 R hypothetical protein complement(2204726..2205079) Mycobacterium leprae TN 910670 NP_302239.1 CDS PPE NC_002677.1 2212448 2214166 R PPE family protein complement(2212448..2214166) Mycobacterium leprae TN 910663 NP_302240.1 CDS ML1829 NC_002677.1 2214813 2215190 D hypothetical protein 2214813..2215190 Mycobacterium leprae TN 910661 NP_302241.1 CDS mapA NC_002677.1 2219402 2220202 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(2219402..2220202) Mycobacterium leprae TN 910659 NP_302242.1 CDS adk NC_002677.1 2220214 2220759 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(2220214..2220759) Mycobacterium leprae TN 910658 NP_302243.1 CDS secY NC_002677.1 2220756 2222072 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(2220756..2222072) Mycobacterium leprae TN 910657 NP_302244.1 CDS ML1835 NC_002677.1 2223216 2223899 R hypothetical protein complement(2223216..2223899) Mycobacterium leprae TN 910655 NP_302245.1 CDS sppA NC_002677.1 2226936 2228744 R endopeptidase IV complement(2226936..2228744) Mycobacterium leprae TN 910651 NP_302246.1 CDS rplO NC_002677.1 2228980 2229420 R late assembly protein; 50S ribosomal protein L15 complement(2228980..2229420) Mycobacterium leprae TN 910650 NP_302247.1 CDS rpmD NC_002677.1 2229421 2229636 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(2229421..2229636) Mycobacterium leprae TN 910649 NP_302248.1 CDS rpsE NC_002677.1 2229639 2230292 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(2229639..2230292) Mycobacterium leprae TN 910648 NP_302249.1 CDS rplR NC_002677.1 2230321 2230686 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(2230321..2230686) Mycobacterium leprae TN 910647 NP_302250.1 CDS rplF NC_002677.1 2230692 2231231 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(2230692..2231231) Mycobacterium leprae TN 910646 NP_302251.1 CDS rpsH NC_002677.1 2231257 2231655 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(2231257..2231655) Mycobacterium leprae TN 910645 NP_302252.1 CDS rpsN NC_002677.1 2231738 2231923 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 complement(2231738..2231923) Mycobacterium leprae TN 910644 NP_302253.1 CDS rplE NC_002677.1 2231929 2232492 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(2231929..2232492) Mycobacterium leprae TN 910643 NP_302254.1 CDS rplX NC_002677.1 2232493 2232810 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(2232493..2232810) Mycobacterium leprae TN 910642 NP_302255.1 CDS rplN NC_002677.1 2232811 2233152 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(2232811..2233152) Mycobacterium leprae TN 910641 NP_302256.1 CDS rpsQ NC_002677.1 2238349 2238732 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(2238349..2238732) Mycobacterium leprae TN 910636 NP_302257.1 CDS rpmC NC_002677.1 2238729 2238974 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(2238729..2238974) Mycobacterium leprae TN 910635 NP_302258.1 CDS rplP NC_002677.1 2238971 2239387 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(2238971..2239387) Mycobacterium leprae TN 910634 NP_302259.1 CDS rpsC NC_002677.1 2239391 2240236 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(2239391..2240236) Mycobacterium leprae TN 910633 NP_302260.1 CDS rplV NC_002677.1 2240236 2240763 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(2240236..2240763) Mycobacterium leprae TN 910632 NP_302261.1 CDS rpsS NC_002677.1 2240760 2241041 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(2240760..2241041) Mycobacterium leprae TN 910631 NP_302262.1 CDS rplB NC_002677.1 2241065 2241907 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(2241065..2241907) Mycobacterium leprae TN 910630 NP_302263.1 CDS rplW NC_002677.1 2241937 2242239 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(2241937..2242239) Mycobacterium leprae TN 910629 NP_302264.1 CDS rplD NC_002677.1 2242239 2242931 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(2242239..2242931) Mycobacterium leprae TN 910628 NP_302265.1 CDS rplC NC_002677.1 2242931 2243587 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(2242931..2243587) Mycobacterium leprae TN 910627 NP_302266.1 CDS rpsJ NC_002677.1 2243600 2243905 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(2243600..2243905) Mycobacterium leprae TN 910626 NP_302267.1 CDS tuf NC_002677.1 2255790 2256980 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(2255790..2256980) Mycobacterium leprae TN 910613 NP_302268.1 CDS fusA NC_002677.1 2257089 2259194 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(2257089..2259194) Mycobacterium leprae TN 910612 NP_302269.1 CDS rpsG NC_002677.1 2259288 2259758 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(2259288..2259758) Mycobacterium leprae TN 910611 NP_302270.1 CDS rpsL NC_002677.1 2259758 2260132 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(2259758..2260132) Mycobacterium leprae TN 910610 NP_302271.1 CDS ML1889 NC_002677.1 2268187 2268945 R Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV complement(2268187..2268945) Mycobacterium leprae TN 910601 NP_302272.1 CDS rpoC NC_002677.1 2269270 2273220 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(2269270..2273220) Mycobacterium leprae TN 910600 NP_302273.1 CDS rpoB NC_002677.1 2273269 2276805 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(2273269..2276805) Mycobacterium leprae TN 910599 NP_302274.1 CDS ML1892 NC_002677.1 2277260 2278276 R ABC transporter ATP-binding protein complement(2277260..2278276) Mycobacterium leprae TN 910598 NP_302275.1 CDS rplL NC_002677.1 2280435 2280827 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(2280435..2280827) Mycobacterium leprae TN 910595 NP_302276.1 CDS rplJ NC_002677.1 2280863 2281396 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(2280863..2281396) Mycobacterium leprae TN 910594 NP_302277.1 CDS ML1898 NC_002677.1 2282288 2283634 D hypothetical protein 2282288..2283634 Mycobacterium leprae TN 910592 NP_302278.1 CDS lipG NC_002677.1 2283634 2284548 D hydrolase 2283634..2284548 Mycobacterium leprae TN 910591 NP_302279.1 CDS mmaA1 NC_002677.1 2284606 2285466 D methyl mycolic acid synthase 1 2284606..2285466 Mycobacterium leprae TN 910590 NP_302280.1 CDS mmaA4 NC_002677.1 2287631 2288527 D methyl mycolic acid synthase 4 2287631..2288527 Mycobacterium leprae TN 910587 NP_302281.1 CDS rplA NC_002677.1 2290309 2291016 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(2290309..2291016) Mycobacterium leprae TN 910586 NP_302282.1 CDS rplK NC_002677.1 2291148 2291576 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(2291148..2291576) Mycobacterium leprae TN 910585 NP_302283.1 CDS nusG NC_002677.1 2291604 2292290 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(2291604..2292290) Mycobacterium leprae TN 910584 NP_302284.1 CDS secE NC_002677.1 2292368 2292808 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(2292368..2292808) Mycobacterium leprae TN 910583 NP_302285.1 CDS ML1908 NC_002677.1 2293144 2293644 R functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC complement(2293144..2293644) Mycobacterium leprae TN 910581 NP_302286.1 CDS ML1909 NC_002677.1 2293648 2294076 R functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB complement(2293648..2294076) Mycobacterium leprae TN 910580 NP_302287.1 CDS ML1910 NC_002677.1 2294063 2294542 R functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA complement(2294063..2294542) Mycobacterium leprae TN 910579 NP_302288.1 CDS rpmG NC_002677.1 2294589 2294756 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(2294589..2294756) Mycobacterium leprae TN 910578 NP_302289.1 CDS ML1911A NC_002677.1 2295156 2295371 R hypothetical protein complement(2295156..2295371) Mycobacterium leprae TN 910575 NP_302290.1 CDS ML1912 NC_002677.1 2295524 2296240 D glyoxylase 2295524..2296240 Mycobacterium leprae TN 910574 NP_302291.1 CDS ML1915 NC_002677.1 2298471 2298815 D hypothetical protein 2298471..2298815 Mycobacterium leprae TN 910345 NP_302292.1 CDS ML1918 NC_002677.1 2301835 2302626 R hypothetical protein complement(2301835..2302626) Mycobacterium leprae TN 910252 NP_302293.1 CDS ML1919 NC_002677.1 2302765 2303406 R carbonic anhydrase complement(2302765..2303406) Mycobacterium leprae TN 910236 NP_302294.1 CDS mutY NC_002677.1 2303405 2304298 D DNA glycosylase 2303405..2304298 Mycobacterium leprae TN 910168 NP_302295.1 CDS ML1921 NC_002677.1 2304307 2305077 R hypothetical protein complement(2304307..2305077) Mycobacterium leprae TN 910125 NP_302296.1 CDS ML1922 NC_002677.1 2305203 2305520 D hypothetical protein 2305203..2305520 Mycobacterium leprae TN 910111 NP_302297.1 CDS lpqF NC_002677.1 2305495 2306859 D hypothetical protein 2305495..2306859 Mycobacterium leprae TN 910110 NP_302298.1 CDS sodC NC_002677.1 2310771 2311493 R superoxide dismutase (Cu-Zn) complement(2310771..2311493) Mycobacterium leprae TN 910108 NP_302299.1 CDS ML1926 NC_002677.1 2311558 2312061 R tuberculin related peptide complement(2311558..2312061) Mycobacterium leprae TN 910107 NP_302300.1 CDS ML1927 NC_002677.1 2312092 2312400 R hypothetical protein complement(2312092..2312400) Mycobacterium leprae TN 910105 NP_302301.1 CDS ML1928 NC_002677.1 2312431 2312568 R hypothetical protein complement(2312431..2312568) Mycobacterium leprae TN 910104 NP_302302.1 CDS def NC_002677.1 2312615 2313208 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 2312615..2313208 Mycobacterium leprae TN 910103 NP_302303.1 CDS ML1932 NC_002677.1 2314821 2315234 D hypothetical protein 2314821..2315234 Mycobacterium leprae TN 910100 NP_302304.1 CDS ML1936 NC_002677.1 2322199 2323269 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(2322199..2323269) Mycobacterium leprae TN 910095 NP_302305.1 CDS ML1937 NC_002677.1 2323320 2324552 D hypothetical protein 2323320..2324552 Mycobacterium leprae TN 910094 NP_302306.1 CDS ispH NC_002677.1 2324563 2325570 R catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase complement(2324563..2325570) Mycobacterium leprae TN 910093 NP_302307.1 CDS ML1939 NC_002677.1 2325739 2326356 D hypothetical protein 2325739..2326356 Mycobacterium leprae TN 910091 NP_302308.1 CDS xseA NC_002677.1 2326353 2327639 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2326353..2327639 Mycobacterium leprae TN 910082 NP_302309.1 CDS xseB NC_002677.1 2327629 2327892 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 2327629..2327892 Mycobacterium leprae TN 910018 NP_302310.1 CDS ML1942 NC_002677.1 2327943 2329073 D cholesterol dehydrogenase 2327943..2329073 Mycobacterium leprae TN 910016 NP_302311.1 CDS ML1945 NC_002677.1 2331776 2332549 R hypothetical protein complement(2331776..2332549) Mycobacterium leprae TN 909852 NP_302312.1 CDS glpX NC_002677.1 2332629 2333615 D type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 2332629..2333615 Mycobacterium leprae TN 909793 NP_302313.2 CDS fumC NC_002677.1 2333642 2335048 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 2333642..2335048 Mycobacterium leprae TN 909446 NP_302314.1 CDS ML1949 NC_002677.1 2336277 2336636 R hypothetical protein complement(2336277..2336636) Mycobacterium leprae TN 909442 NP_302315.1 CDS ML1950 NC_002677.1 2336689 2337564 R carbohydrate degrading enzyme complement(2336689..2337564) Mycobacterium leprae TN 909441 NP_302316.1 CDS phoH2 NC_002677.1 2337619 2338920 R PhoH-like protein complement(2337619..2338920) Mycobacterium leprae TN 909438 NP_302317.1 CDS desA2 NC_002677.1 2339270 2340097 R acyl-[ACP] desaturase complement(2339270..2340097) Mycobacterium leprae TN 909437 NP_302318.1 CDS glyA NC_002677.1 2340154 2341434 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2340154..2341434) Mycobacterium leprae TN 909436 NP_302319.1 CDS coaA NC_002677.1 2341563 2342501 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 2341563..2342501 Mycobacterium leprae TN 909435 NP_302320.2 CDS truA NC_002677.1 2343329 2344291 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2343329..2344291) Mycobacterium leprae TN 909431 NP_302321.1 CDS rplQ NC_002677.1 2344170 2344682 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(2344170..2344682) Mycobacterium leprae TN 909428 NP_302322.1 CDS rpoA NC_002677.1 2344706 2345749 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(2344706..2345749) Mycobacterium leprae TN 909427 NP_302323.1 CDS rpsD NC_002677.1 2345834 2346439 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(2345834..2346439) Mycobacterium leprae TN 909424 NP_302324.1 CDS rpsK NC_002677.1 2346473 2346889 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(2346473..2346889) Mycobacterium leprae TN 909287 NP_302325.1 CDS rpsM NC_002677.1 2346893 2347267 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(2346893..2347267) Mycobacterium leprae TN 909225 NP_302326.1 CDS rpmJ NC_002677.1 2347444 2347557 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(2347444..2347557) Mycobacterium leprae TN 909164 NP_302327.1 CDS infA NC_002677.1 2347597 2347818 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(2347597..2347818) Mycobacterium leprae TN 909145 NP_302328.1 CDS rmlB NC_002677.1 2348333 2349334 D dTDP-glucose 4,6-dehydratase 2348333..2349334 Mycobacterium leprae TN 909140 NP_302329.1 CDS rmlC NC_002677.1 2349336 2349944 D dTDP-4-dehydrorhamnose 3,5-epimerase 2349336..2349944 Mycobacterium leprae TN 909135 NP_302330.1 CDS lpqH NC_002677.1 2349989 2350474 D lipoprotein 2349989..2350474 Mycobacterium leprae TN 909134 NP_302331.1 CDS ML1972 NC_002677.1 2356311 2356541 R hypothetical protein complement(2356311..2356541) Mycobacterium leprae TN 909122 NP_302332.1 CDS ML1974 NC_002677.1 2358452 2360170 D permease 2358452..2360170 Mycobacterium leprae TN 909118 NP_302333.1 CDS ML1976 NC_002677.1 2361219 2361566 R hypothetical protein complement(2361219..2361566) Mycobacterium leprae TN 909115 NP_302334.1 CDS ML1979 NC_002677.1 2363934 2364341 R hypothetical protein complement(2363934..2364341) Mycobacterium leprae TN 909111 NP_302335.1 CDS ML1982 NC_002677.1 2366597 2366905 D hypothetical protein 2366597..2366905 Mycobacterium leprae TN 909108 NP_302336.1 CDS ML1983 NC_002677.1 2367418 2367885 D hypothetical protein 2367418..2367885 Mycobacterium leprae TN 909107 NP_302337.1 CDS aceA NC_002677.1 2369802 2372198 R Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase complement(2369802..2372198) Mycobacterium leprae TN 909102 NP_302338.1 CDS ctpA NC_002677.1 2373427 2375727 D cation-transporting ATPase 2373427..2375727 Mycobacterium leprae TN 909100 NP_302339.1 CDS ML1988 NC_002677.1 2375705 2376418 R hypothetical protein complement(2375705..2376418) Mycobacterium leprae TN 909099 NP_302340.1 CDS ML1989 NC_002677.1 2376735 2377085 R hypothetical protein complement(2376735..2377085) Mycobacterium leprae TN 909098 NP_302341.1 CDS ML1990 NC_002677.1 2377165 2377407 R hypothetical protein complement(2377165..2377407) Mycobacterium leprae TN 909097 NP_302342.1 CDS PPE NC_002677.1 2378494 2379900 D PPE family protein 2378494..2379900 Mycobacterium leprae TN 909096 NP_302343.1 CDS ML1992 NC_002677.1 2380049 2380918 D oxidoreductase 2380049..2380918 Mycobacterium leprae TN 909095 NP_302344.1 CDS ML1993 NC_002677.1 2380915 2381466 D hypothetical protein 2380915..2381466 Mycobacterium leprae TN 909094 NP_302345.1 CDS fadD10 NC_002677.1 2381496 2383094 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2381496..2383094 Mycobacterium leprae TN 909091 NP_302346.1 CDS ML1995 NC_002677.1 2383087 2383323 D hypothetical protein 2383087..2383323 Mycobacterium leprae TN 909087 NP_302347.1 CDS nrp NC_002677.1 2383320 2387525 D peptide synthase 2383320..2387525 Mycobacterium leprae TN 909086 NP_302348.1 CDS ML1997 NC_002677.1 2387532 2388164 R hypothetical protein complement(2387532..2388164) Mycobacterium leprae TN 909083 NP_302349.1 CDS ML1998 NC_002677.1 2388277 2390256 D hypothetical protein 2388277..2390256 Mycobacterium leprae TN 909080 NP_302350.1 CDS ctpB NC_002677.1 2391317 2393569 R cation-transporting ATPase complement(2391317..2393569) Mycobacterium leprae TN 909077 NP_302351.1 CDS ML2010 NC_002677.1 2402973 2403434 D lipoprotein 2402973..2403434 Mycobacterium leprae TN 909065 NP_302352.1 CDS aao NC_002677.1 2403489 2404451 D D-amino acid oxidase 2403489..2404451 Mycobacterium leprae TN 909061 NP_302353.1 CDS ML2012 NC_002677.1 2404469 2404888 R hypothetical protein complement(2404469..2404888) Mycobacterium leprae TN 909059 NP_302354.1 CDS ML2013 NC_002677.1 2405356 2405736 R hypothetical protein complement(2405356..2405736) Mycobacterium leprae TN 909056 NP_302355.1 CDS cinA NC_002677.1 2407300 2408598 R competence damage-inducible protein A complement(2407300..2408598) Mycobacterium leprae TN 909054 NP_302356.1 CDS ML2020 NC_002677.1 2411315 2412229 D hypothetical protein 2411315..2412229 Mycobacterium leprae TN 909047 NP_302357.1 CDS ML2022 NC_002677.1 2413644 2414168 R hypothetical protein complement(2413644..2414168) Mycobacterium leprae TN 909045 NP_302358.1 CDS ML2023 NC_002677.1 2414264 2414668 R hypothetical protein complement(2414264..2414668) Mycobacterium leprae TN 909044 NP_302359.1 CDS fbpB NC_002677.1 2418620 2419603 D antigen 85A, mycolyltransferase 2418620..2419603 Mycobacterium leprae TN 909036 NP_302360.1 CDS ML2030 NC_002677.1 2420647 2421120 D hypothetical protein 2420647..2421120 Mycobacterium leprae TN 909030 NP_302361.1 CDS ML2031 NC_002677.1 2421151 2421606 D hypothetical protein 2421151..2421606 Mycobacterium leprae TN 909028 NP_302362.1 CDS ML2035 NC_002677.1 2425166 2425429 R hypothetical protein complement(2425166..2425429) Mycobacterium leprae TN 909020 NP_302363.1 CDS bfrA NC_002677.1 2429323 2429802 R bacterioferritin complement(2429323..2429802) Mycobacterium leprae TN 909017 NP_302364.1 CDS oxyR NC_002677.1 2431984 2432919 R LysR family transcriptional regulator complement(2431984..2432919) Mycobacterium leprae TN 909008 NP_302365.1 CDS ahpC NC_002677.1 2433029 2433616 D alkyl hydroperoxide reductase 2433029..2433616 Mycobacterium leprae TN 909002 NP_302366.1 CDS ML2044 NC_002677.1 2434368 2434589 R hypothetical protein complement(2434368..2434589) Mycobacterium leprae TN 909000 NP_302367.1 CDS ML2045 NC_002677.1 2434998 2435255 D hypothetical protein 2434998..2435255 Mycobacterium leprae TN 908999 NP_302368.1 CDS lldD2 NC_002677.1 2435559 2436803 D L-lactate dehydrogenase 2435559..2436803 Mycobacterium leprae TN 908996 NP_302369.1 CDS ML2048 NC_002677.1 2437805 2438062 D hypothetical protein 2437805..2438062 Mycobacterium leprae TN 908993 NP_302370.1 CDS ML2053 NC_002677.1 2441097 2442104 R alcohol dehydrogenase complement(2441097..2442104) Mycobacterium leprae TN 908988 NP_302371.1 CDS ML2054 NC_002677.1 2442182 2442481 R hypothetical protein complement(2442182..2442481) Mycobacterium leprae TN 908986 NP_302372.1 CDS modD NC_002677.1 2442641 2443504 R cell surface protein (associated with virulence) complement(2442641..2443504) Mycobacterium leprae TN 908985 NP_302373.1 CDS ML2059 NC_002677.1 2446556 2447230 D short chain dehydrogenase 2446556..2447230 Mycobacterium leprae TN 908980 NP_302374.1 CDS ML2061 NC_002677.1 2448422 2449822 D dehydrogenase 2448422..2449822 Mycobacterium leprae TN 908976 NP_302375.1 CDS ML2063 NC_002677.1 2450656 2451084 D regulator 2450656..2451084 Mycobacterium leprae TN 908973 NP_302376.1 CDS ML2064 NC_002677.1 2451089 2452039 D hypothetical protein 2451089..2452039 Mycobacterium leprae TN 908972 NP_302377.1 CDS gnd NC_002677.1 2452179 2453630 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2452179..2453630 Mycobacterium leprae TN 908971 NP_302378.1 CDS guaB1 NC_002677.1 2453700 2455136 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 2453700..2455136 Mycobacterium leprae TN 908961 NP_302379.1 CDS glcB NC_002677.1 2457996 2460191 D catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 2457996..2460191 Mycobacterium leprae TN 908958 NP_302380.1 CDS ML2070 NC_002677.1 2460317 2462518 D hypothetical protein 2460317..2462518 Mycobacterium leprae TN 910800 NP_302381.1 CDS gcvB NC_002677.1 2463419 2466277 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(2463419..2466277) Mycobacterium leprae TN 908561 NP_302382.1 CDS ML2073 NC_002677.1 2466445 2467140 R hypothetical protein complement(2466445..2467140) Mycobacterium leprae TN 908955 NP_302383.1 CDS ML2074 NC_002677.1 2467373 2467867 R hypothetical protein complement(2467373..2467867) Mycobacterium leprae TN 908396 NP_302384.1 CDS ML2075 NC_002677.1 2467984 2468739 R hypothetical protein complement(2467984..2468739) Mycobacterium leprae TN 908954 NP_302385.1 CDS ML2076 NC_002677.1 2468736 2469224 R hypothetical protein complement(2468736..2469224) Mycobacterium leprae TN 908186 NP_302386.1 CDS gcvH NC_002677.1 2469468 2469866 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(2469468..2469866) Mycobacterium leprae TN 909238 NP_302387.1 CDS pgsA2 NC_002677.1 2472087 2472707 R CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2472087..2472707) Mycobacterium leprae TN 908950 NP_302388.1 CDS secA2 NC_002677.1 2472769 2475105 R SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(2472769..2475105) Mycobacterium leprae TN 908485 NP_302389.1 CDS ilvG NC_002677.1 2475213 2476859 R hypothetical protein complement(2475213..2476859) Mycobacterium leprae TN 908947 NP_302390.1 CDS ML2084 NC_002677.1 2476953 2478869 D multidrug resistance pump 2476953..2478869 Mycobacterium leprae TN 908477 NP_302391.1 CDS ML2088 NC_002677.1 2481544 2482848 R cytochrome p450 complement(2481544..2482848) Mycobacterium leprae TN 908944 NP_302392.1 CDS ML2091 NC_002677.1 2487709 2487894 D hypothetical protein 2487709..2487894 Mycobacterium leprae TN 908939 NP_302393.1 CDS pstA1 NC_002677.1 2489131 2490045 R membrane-bound component of phosphate transport complement(2489131..2490045) Mycobacterium leprae TN 908938 NP_302394.1 CDS pstC2 NC_002677.1 2490063 2491022 R membrane-bound component of phosphate transport complement(2490063..2491022) Mycobacterium leprae TN 908937 NP_302395.1 CDS phoS2 NC_002677.1 2491065 2492174 R PstS component of phosphate uptake complement(2491065..2492174) Mycobacterium leprae TN 908711 NP_302396.1 CDS mntH NC_002677.1 2494502 2495782 D manganese transport protein MntH 2494502..2495782 Mycobacterium leprae TN 908932 NP_302397.1 CDS ML2111 NC_002677.1 2512539 2512973 R hypothetical protein complement(2512539..2512973) Mycobacterium leprae TN 908213 NP_302398.1 CDS ML2113 NC_002677.1 2513870 2514415 R hypothetical protein complement(2513870..2514415) Mycobacterium leprae TN 908791 NP_302399.1 CDS ML2114 NC_002677.1 2514412 2514582 R hypothetical protein complement(2514412..2514582) Mycobacterium leprae TN 908915 NP_302400.1 CDS echA6 NC_002677.1 2518770 2519513 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2518770..2519513) Mycobacterium leprae TN 908912 NP_302401.1 CDS ML2121 NC_002677.1 2521540 2521950 R hypothetical protein complement(2521540..2521950) Mycobacterium leprae TN 908910 NP_302402.1 CDS ML2123 NC_002677.1 2524150 2524851 D two-component response regulator 2524150..2524851 Mycobacterium leprae TN 908909 NP_302403.1 CDS ML2124 NC_002677.1 2524869 2526209 D sensor histidine kinase 2524869..2526209 Mycobacterium leprae TN 910405 NP_302404.1 CDS ML2129 NC_002677.1 2530687 2530848 R PE-family protein complement(2530687..2530848) Mycobacterium leprae TN 908904 NP_302405.1 CDS gltA NC_002677.1 2531614 2532909 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(2531614..2532909) Mycobacterium leprae TN 909309 NP_302406.2 CDS pdxH NC_002677.1 2533158 2533784 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(2533158..2533784) Mycobacterium leprae TN 908903 NP_302407.1 CDS fprB NC_002677.1 2535813 2537480 R ferredoxin, ferredoxin-NADP reductase complement(2535813..2537480) Mycobacterium leprae TN 909093 NP_302408.1 CDS ML2135 NC_002677.1 2537496 2538521 R transmembrane protein complement(2537496..2538521) Mycobacterium leprae TN 908285 NP_302409.1 CDS serC NC_002677.1 2538735 2539865 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 2538735..2539865 Mycobacterium leprae TN 908898 NP_302410.1 CDS ML2137 NC_002677.1 2539983 2540738 D hypothetical protein 2539983..2540738 Mycobacterium leprae TN 908321 NP_302411.1 CDS ML2140 NC_002677.1 2541985 2542416 R MarR family transcriptional regulator complement(2541985..2542416) Mycobacterium leprae TN 908892 NP_302412.1 CDS ML2141 NC_002677.1 2542620 2542895 D hypothetical protein 2542620..2542895 Mycobacterium leprae TN 908891 NP_302413.1 CDS ML2142 NC_002677.1 2543007 2543816 R hypothetical protein complement(2543007..2543816) Mycobacterium leprae TN 909161 NP_302414.1 CDS ML2143 NC_002677.1 2543926 2545665 D hypothetical protein 2543926..2545665 Mycobacterium leprae TN 908890 NP_302415.1 CDS ML2144 NC_002677.1 2545673 2546161 D hypothetical protein 2545673..2546161 Mycobacterium leprae TN 909301 NP_302416.1 CDS cspB NC_002677.1 2552011 2552421 R cold shock protein complement(2552011..2552421) Mycobacterium leprae TN 908888 NP_302417.1 CDS ML2151 NC_002677.1 2554745 2555269 D hypothetical protein 2554745..2555269 Mycobacterium leprae TN 909175 NP_302418.1 CDS ML2155 NC_002677.1 2556716 2556940 R hypothetical protein complement(2556716..2556940) Mycobacterium leprae TN 908308 NP_302419.1 CDS ML2156 NC_002677.1 2557038 2559299 D DNA-binding protein 2557038..2559299 Mycobacterium leprae TN 908878 NP_302420.1 CDS ML2157 NC_002677.1 2559336 2560985 D DNA helicase 2559336..2560985 Mycobacterium leprae TN 908199 NP_302421.1 CDS ML2158 NC_002677.1 2561097 2561489 R hypothetical protein complement(2561097..2561489) Mycobacterium leprae TN 908343 NP_302422.1 CDS fadB NC_002677.1 2569161 2571305 R fatty oxidation complex alpha subunit complement(2569161..2571305) Mycobacterium leprae TN 908456 NP_302423.1 CDS fadA NC_002677.1 2571310 2572521 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(2571310..2572521) Mycobacterium leprae TN 908875 NP_302424.1 CDS pdc NC_002677.1 2575965 2577674 D pyruvate (or indolepyruvate) decarboxylase 2575965..2577674 Mycobacterium leprae TN 908871 NP_302425.1 CDS ML2170 NC_002677.1 2579209 2579433 R hypothetical protein complement(2579209..2579433) Mycobacterium leprae TN 908867 NP_302426.1 CDS ML2172 NC_002677.1 2583247 2583603 D hypothetical protein 2583247..2583603 Mycobacterium leprae TN 908866 NP_302427.1 CDS cdd NC_002677.1 2586141 2586545 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2586141..2586545 Mycobacterium leprae TN 908480 NP_302428.1 CDS ML2176 NC_002677.1 2588187 2588444 D hypothetical protein 2588187..2588444 Mycobacterium leprae TN 909284 NP_302429.1 CDS ML2177 NC_002677.1 2588597 2589550 R uridine phosphorylase complement(2588597..2589550) Mycobacterium leprae TN 908859 NP_302430.1 CDS ML2178 NC_002677.1 2589791 2590042 R hypothetical protein complement(2589791..2590042) Mycobacterium leprae TN 908858 NP_302431.1 CDS desA1 NC_002677.1 2599216 2600232 D acyl-[ACP] desaturase 2599216..2600232 Mycobacterium leprae TN 908845 NP_302432.1 CDS ML2186 NC_002677.1 2600276 2601430 D NifR3/Smm1 family transcriptional regulator 2600276..2601430 Mycobacterium leprae TN 909337 NP_302433.1 CDS phoY1 NC_002677.1 2603578 2604246 D phosphate transport system regulator 2603578..2604246 Mycobacterium leprae TN 909204 NP_302434.1 CDS phoT NC_002677.1 2604273 2605049 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(2604273..2605049) Mycobacterium leprae TN 908843 NP_302435.1 CDS phoS3 NC_002677.1 2606831 2608120 R phosphate-binding protein 3 complement(2606831..2608120) Mycobacterium leprae TN 908840 NP_302436.1 CDS ML2193 NC_002677.1 2608113 2609048 R acetyltransferase complement(2608113..2609048) Mycobacterium leprae TN 908928 NP_302437.1 CDS ML2195 NC_002677.1 2609965 2610816 D hypothetical protein 2609965..2610816 Mycobacterium leprae TN 908837 NP_302438.1 CDS thiX NC_002677.1 2610909 2611331 D thiredoxin 2610909..2611331 Mycobacterium leprae TN 908935 NP_302439.1 CDS ML2197 NC_002677.1 2611544 2612029 D hypothetical protein 2611544..2612029 Mycobacterium leprae TN 908885 NP_302440.1 CDS cysA3 NC_002677.1 2612061 2612894 D thiosulfate sulfurtransferase 2612061..2612894 Mycobacterium leprae TN 908836 NP_302441.1 CDS ML2199 NC_002677.1 2612896 2613198 D hypothetical protein 2612896..2613198 Mycobacterium leprae TN 908835 NP_302442.1 CDS ML2200 NC_002677.1 2613457 2614143 D hypothetical protein 2613457..2614143 Mycobacterium leprae TN 908461 NP_302443.1 CDS ML2201 NC_002677.1 2615448 2615687 R hypothetical protein complement(2615448..2615687) Mycobacterium leprae TN 908834 NP_302444.1 CDS ML2203 NC_002677.1 2617849 2618970 D hypothetical protein 2617849..2618970 Mycobacterium leprae TN 908833 NP_302445.1 CDS ML2204 NC_002677.1 2619139 2619327 D hypothetical protein 2619139..2619327 Mycobacterium leprae TN 908447 NP_302446.1 CDS purM NC_002677.1 2619421 2620515 R catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase complement(2619421..2620515) Mycobacterium leprae TN 908828 NP_302447.1 CDS purF NC_002677.1 2620615 2622285 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2620615..2622285) Mycobacterium leprae TN 908827 NP_302448.1 CDS ML2207 NC_002677.1 2622297 2622692 R hypothetical protein complement(2622297..2622692) Mycobacterium leprae TN 908510 NP_302449.1 CDS cpsY NC_002677.1 2624324 2625952 D UDP-glucose-4-epimerase 2624324..2625952 Mycobacterium leprae TN 908309 NP_302450.1 CDS ML2210 NC_002677.1 2625867 2626820 R hypothetical protein complement(2625867..2626820) Mycobacterium leprae TN 908821 NP_302451.1 CDS purL NC_002677.1 2626953 2629217 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II complement(2626953..2629217) Mycobacterium leprae TN 908524 NP_302452.1 CDS pepC NC_002677.1 2630069 2631400 R catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase complement(2630069..2631400) Mycobacterium leprae TN 908471 NP_302453.1 CDS purQ NC_002677.1 2636005 2636679 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I complement(2636005..2636679) Mycobacterium leprae TN 908813 NP_302454.1 CDS ML2219A NC_002677.1 2636676 2636915 R With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS complement(2636676..2636915) Mycobacterium leprae TN 908812 NP_302455.1 CDS ptrB NC_002677.1 2642860 2645034 R oligopeptidase B complement(2642860..2645034) Mycobacterium leprae TN 908152 NP_302456.1 CDS hemH NC_002677.1 2645031 2645924 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2645031..2645924) Mycobacterium leprae TN 908227 NP_302457.1 CDS ML2228 NC_002677.1 2645990 2646610 D hypothetical protein 2645990..2646610 Mycobacterium leprae TN 908200 NP_302458.1 CDS purB NC_002677.1 2647523 2648941 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(2647523..2648941) Mycobacterium leprae TN 908158 NP_302459.1 CDS purD NC_002677.1 2653337 2654605 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(2653337..2654605) Mycobacterium leprae TN 908797 NP_302460.1 CDS ML2237 NC_002677.1 2656446 2656850 D hypothetical protein 2656446..2656850 Mycobacterium leprae TN 908360 NP_302461.1 CDS ML2242 NC_002677.1 2661044 2661775 R hypothetical protein complement(2661044..2661775) Mycobacterium leprae TN 908784 NP_302462.1 CDS ML2244 NC_002677.1 2667223 2667564 R hypothetical protein complement(2667223..2667564) Mycobacterium leprae TN 908783 NP_302463.1 CDS cpsA NC_002677.1 2670322 2671872 D hypothetical protein 2670322..2671872 Mycobacterium leprae TN 909381 NP_302464.1 CDS ML2249 NC_002677.1 2672720 2673037 R hypothetical protein complement(2672720..2673037) Mycobacterium leprae TN 908463 NP_302465.1 CDS ML2252 NC_002677.1 2675767 2676003 R hypothetical protein complement(2675767..2676003) Mycobacterium leprae TN 908777 NP_302466.1 CDS ML2253 NC_002677.1 2676319 2676534 R antigen 84-like protein complement(2676319..2676534) Mycobacterium leprae TN 908863 NP_302467.1 CDS otsA NC_002677.1 2677263 2678759 D trehalose-phosphate synthase 2677263..2678759 Mycobacterium leprae TN 908776 NP_302468.1 CDS menE NC_002677.1 2681377 2682483 R O-succinylbenzoic acid--CoA ligase complement(2681377..2682483) Mycobacterium leprae TN 908454 NP_302469.1 CDS ML2258 NC_002677.1 2682528 2682830 R hypothetical protein complement(2682528..2682830) Mycobacterium leprae TN 908768 NP_302470.1 CDS ML2259 NC_002677.1 2682860 2683150 R hypothetical protein complement(2682860..2683150) Mycobacterium leprae TN 908211 NP_302471.1 CDS pitA NC_002677.1 2683147 2684391 R low-affinity inorganic phosphate transporter complement(2683147..2684391) Mycobacterium leprae TN 908765 NP_302472.1 CDS ML2261 NC_002677.1 2684489 2684905 R hypothetical protein complement(2684489..2684905) Mycobacterium leprae TN 908761 NP_302473.1 CDS menB NC_002677.1 2686559 2687461 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2686559..2687461) Mycobacterium leprae TN 908760 NP_302474.1 CDS ML2264 NC_002677.1 2687458 2688069 R hypothetical protein complement(2687458..2688069) Mycobacterium leprae TN 908759 NP_302475.1 CDS ML2265 NC_002677.1 2688062 2688283 R hypothetical protein complement(2688062..2688283) Mycobacterium leprae TN 908150 NP_302476.1 CDS ML2268 NC_002677.1 2691797 2692801 D catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2691797..2692801 Mycobacterium leprae TN 908756 NP_302477.1 CDS ML2269 NC_002677.1 2692764 2693561 D hydrolase 2692764..2693561 Mycobacterium leprae TN 908755 NP_302478.1 CDS menD NC_002677.1 2693805 2695475 D SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2693805..2695475 Mycobacterium leprae TN 908753 NP_302479.1 CDS ML2271 NC_002677.1 2695503 2696030 D hypothetical protein 2695503..2696030 Mycobacterium leprae TN 908751 NP_302480.2 CDS ubiE NC_002677.1 2697307 2697999 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 2697307..2697999 Mycobacterium leprae TN 908749 NP_302481.1 CDS ML2274 NC_002677.1 2698017 2698355 R hypothetical protein complement(2698017..2698355) Mycobacterium leprae TN 908748 NP_302482.1 CDS ML2276 NC_002677.1 2698907 2700133 R FAD-linked oxidoreductase complement(2698907..2700133) Mycobacterium leprae TN 908747 NP_302483.1 CDS ML2277 NC_002677.1 2700164 2701156 D polyprenyl diphosphate synthase component 2700164..2701156 Mycobacterium leprae TN 908745 NP_302484.1 CDS htpX NC_002677.1 2701267 2702130 D metalloprotease; heat shock protein HtpX 2701267..2702130 Mycobacterium leprae TN 908742 NP_302485.1 CDS ML2279 NC_002677.1 2702658 2704148 R transmembrane transport protein complement(2702658..2704148) Mycobacterium leprae TN 908420 NP_302486.1 CDS ML2283 NC_002677.1 2707732 2708046 D hypothetical protein 2707732..2708046 Mycobacterium leprae TN 908739 NP_302487.1 CDS ML2284 NC_002677.1 2708438 2708797 D hypothetical protein 2708438..2708797 Mycobacterium leprae TN 909250 NP_302488.1 CDS ML2288 NC_002677.1 2712436 2712660 R hypothetical protein complement(2712436..2712660) Mycobacterium leprae TN 908232 NP_302489.1 CDS ML2289 NC_002677.1 2713408 2714178 R hypothetical protein complement(2713408..2714178) Mycobacterium leprae TN 908735 NP_302490.1 CDS ML2295 NC_002677.1 2720556 2721260 R hypothetical protein complement(2720556..2721260) Mycobacterium leprae TN 908732 NP_302491.1 CDS ML2296 NC_002677.1 2721464 2722009 D hypothetical protein 2721464..2722009 Mycobacterium leprae TN 908730 NP_302492.1 CDS ML2297 NC_002677.1 2722010 2722984 D hydrolase 2722010..2722984 Mycobacterium leprae TN 908207 NP_302493.1 CDS ML2298 NC_002677.1 2722977 2724182 R membrane-associated serine protease complement(2722977..2724182) Mycobacterium leprae TN 908147 NP_302494.1 CDS ML2299 NC_002677.1 2724179 2724979 R hypothetical protein complement(2724179..2724979) Mycobacterium leprae TN 908214 NP_302495.1 CDS ML2300 NC_002677.1 2725025 2725672 R hypothetical protein complement(2725025..2725672) Mycobacterium leprae TN 909282 NP_302496.1 CDS nth NC_002677.1 2725723 2726484 R endonuclease III complement(2725723..2726484) Mycobacterium leprae TN 908145 NP_302497.1 CDS ML2302 NC_002677.1 2726910 2727584 D Crp/Fnr family transcriptional regulator 2726910..2727584 Mycobacterium leprae TN 908399 NP_302498.1 CDS ML2303 NC_002677.1 2727662 2728450 R hydrolase complement(2727662..2728450) Mycobacterium leprae TN 908724 NP_302499.1 CDS ML2304 NC_002677.1 2728456 2728980 R hypothetical protein complement(2728456..2728980) Mycobacterium leprae TN 908723 NP_302500.1 CDS ML2305 NC_002677.1 2729191 2730216 D anion transporter protein 2729191..2730216 Mycobacterium leprae TN 908495 NP_302501.1 CDS ML2306 NC_002677.1 2730213 2731358 D anion transporter protein 2730213..2731358 Mycobacterium leprae TN 908722 NP_302502.1 CDS ML2307 NC_002677.1 2731463 2731708 R hypothetical protein complement(2731463..2731708) Mycobacterium leprae TN 908721 NP_302503.1 CDS pon1 NC_002677.1 2732187 2734598 D penicillin binding protein (class A) 2732187..2734598 Mycobacterium leprae TN 908216 NP_302504.1 CDS ML2309 NC_002677.1 2734787 2735779 D hypothetical protein 2734787..2735779 Mycobacterium leprae TN 908720 NP_302505.1 CDS ML2312 NC_002677.1 2739921 2740511 D hypothetical protein 2739921..2740511 Mycobacterium leprae TN 908202 NP_302506.1 CDS ML2313 NC_002677.1 2740945 2741547 D hypothetical protein 2740945..2741547 Mycobacterium leprae TN 908716 NP_302507.1 CDS glpK NC_002677.1 2741813 2743339 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(2741813..2743339) Mycobacterium leprae TN 908659 NP_302508.1 CDS ML2320 NC_002677.1 2747152 2747799 R hypothetical protein complement(2747152..2747799) Mycobacterium leprae TN 908648 NP_302509.1 CDS ML2321 NC_002677.1 2750468 2751478 R hypothetical protein complement(2750468..2751478) Mycobacterium leprae TN 908700 NP_302510.1 CDS asd NC_002677.1 2751624 2752679 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(2751624..2752679) Mycobacterium leprae TN 908669 NP_302511.1 CDS ask NC_002677.1 2752679 2753944 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase complement(2752679..2753944) Mycobacterium leprae TN 908699 NP_302512.2 CDS leuA NC_002677.1 2754769 2756463 D 2-isopropylmalate synthase 2754769..2756463 Mycobacterium leprae TN 908681 NP_302513.1 CDS ML2326 NC_002677.1 2757741 2758976 D ligase 2757741..2758976 Mycobacterium leprae TN 908692 NP_302514.1 CDS ML2327 NC_002677.1 2758984 2759676 D hypothetical protein 2758984..2759676 Mycobacterium leprae TN 908691 NP_302515.1 CDS recR NC_002677.1 2760630 2761241 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(2760630..2761241) Mycobacterium leprae TN 908695 NP_302516.1 CDS ML2330 NC_002677.1 2761253 2761603 R hypothetical protein complement(2761253..2761603) Mycobacterium leprae TN 908677 NP_302517.1 CDS ML2331 NC_002677.1 2761703 2762473 D hypothetical protein 2761703..2762473 Mycobacterium leprae TN 908688 NP_302518.1 CDS ML2332 NC_002677.1 2762489 2762926 R hypothetical protein complement(2762489..2762926) Mycobacterium leprae TN 908687 NP_302519.1 CDS ML2333 NC_002677.1 2763015 2764394 D hypothetical protein 2763015..2764394 Mycobacterium leprae TN 908651 NP_302520.1 CDS ML2334 NC_002677.1 2764448 2765710 D hypothetical protein 2764448..2765710 Mycobacterium leprae TN 908686 NP_302521.1 CDS dnaZX NC_002677.1 2765707 2767542 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(2765707..2767542) Mycobacterium leprae TN 908684 NP_302522.1 CDS ML2336 NC_002677.1 2767652 2769043 R hypothetical protein complement(2767652..2769043) Mycobacterium leprae TN 908683 NP_302523.1 CDS ML2337 NC_002677.1 2769442 2770194 D hypothetical protein 2769442..2770194 Mycobacterium leprae TN 908685 NP_302524.1 CDS ML2341 NC_002677.1 2779477 2781675 R regulatory protein complement(2779477..2781675) Mycobacterium leprae TN 908369 NP_302525.1 CDS ML2346 NC_002677.1 2787096 2788001 R hypothetical protein complement(2787096..2788001) Mycobacterium leprae TN 908676 NP_302526.1 CDS ML2347 NC_002677.1 2788300 2789310 D hypothetical protein 2788300..2789310 Mycobacterium leprae TN 908672 NP_302527.1 CDS ML2348 NC_002677.1 2789501 2790766 D glycosyl transferase family protein 2789501..2790766 Mycobacterium leprae TN 908657 NP_302528.1 CDS ML2349 NC_002677.1 2790912 2792183 R required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase complement(2790912..2792183) Mycobacterium leprae TN 908671 NP_302529.1 CDS ML2350 NC_002677.1 2792232 2793062 R antibiotic resistance membrane protein complement(2792232..2793062) Mycobacterium leprae TN 908701 NP_302530.1 CDS ML2351 NC_002677.1 2793059 2793925 R antibiotic resistance membrane protein complement(2793059..2793925) Mycobacterium leprae TN 908670 NP_302531.1 CDS ML2352 NC_002677.1 2793922 2794917 R antibiotic resistance efflux protein complement(2793922..2794917) Mycobacterium leprae TN 908391 NP_302532.1 CDS ML2353 NC_002677.1 2794928 2799397 R polyketide synthase complement(2794928..2799397) Mycobacterium leprae TN 908668 NP_302533.1 CDS ML2354 NC_002677.1 2799404 2804872 R polyketide synthase complement(2799404..2804872) Mycobacterium leprae TN 909375 NP_302534.1 CDS ML2355 NC_002677.1 2804869 2811474 R polyketide synthase complement(2804869..2811474) Mycobacterium leprae TN 908660 NP_302535.1 CDS ML2356 NC_002677.1 2811471 2816093 R polyketide synthase complement(2811471..2816093) Mycobacterium leprae TN 908658 NP_302536.1 CDS ML2357 NC_002677.1 2816094 2821709 R polyketide synthase complement(2816094..2821709) Mycobacterium leprae TN 908254 NP_302537.1 CDS fadD26 NC_002677.1 2821706 2823457 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(2821706..2823457) Mycobacterium leprae TN 908645 NP_302538.1 CDS ML2359 NC_002677.1 2824103 2824888 R thioesterase complement(2824103..2824888) Mycobacterium leprae TN 908644 NP_302539.1 CDS ML2366 NC_002677.1 2834617 2834958 R hypothetical protein complement(2834617..2834958) Mycobacterium leprae TN 909324 NP_302540.1 CDS ML2377 NC_002677.1 2846366 2846830 D small membrane protein 2846366..2846830 Mycobacterium leprae TN 908627 NP_302541.1 CDS ML2378 NC_002677.1 2846827 2849706 D large membrane protein 2846827..2849706 Mycobacterium leprae TN 908370 NP_302542.1 CDS ML2379 NC_002677.1 2849880 2850209 R hypothetical protein complement(2849880..2850209) Mycobacterium leprae TN 908448 NP_302543.1 CDS ML2380 NC_002677.1 2850483 2850944 R hypothetical protein complement(2850483..2850944) Mycobacterium leprae TN 908626 NP_302544.1 CDS lpd NC_002677.1 2856881 2858284 D E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 2856881..2858284 Mycobacterium leprae TN 908174 NP_302545.1 CDS ML2388 NC_002677.1 2858302 2858607 D hypothetical protein 2858302..2858607 Mycobacterium leprae TN 908619 NP_302546.1 CDS ML2390 NC_002677.1 2861300 2861605 R hypothetical protein complement(2861300..2861605) Mycobacterium leprae TN 909635 NP_302547.1 CDS ML2391 NC_002677.1 2861602 2862474 R hypothetical protein complement(2861602..2862474) Mycobacterium leprae TN 908614 NP_302548.1 CDS ML2392 NC_002677.1 2862579 2863013 D hypothetical protein 2862579..2863013 Mycobacterium leprae TN 908693 NP_302549.1 CDS greA NC_002677.1 2863237 2863731 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 2863237..2863731 Mycobacterium leprae TN 908542 NP_302550.1 CDS metB NC_002677.1 2863794 2864960 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(2863794..2864960) Mycobacterium leprae TN 908547 NP_302551.1 CDS Ag36 NC_002677.1 2865040 2865789 R hypothetical protein complement(2865040..2865789) Mycobacterium leprae TN 908610 NP_302552.1 CDS cysM2 NC_002677.1 2865939 2867333 R cystathionine [beta]-synthase complement(2865939..2867333) Mycobacterium leprae TN 908609 NP_302553.1 CDS ML2400 NC_002677.1 2870652 2871509 R transmembrane protein complement(2870652..2871509) Mycobacterium leprae TN 908606 NP_302554.1 CDS ML2401 NC_002677.1 2871769 2872806 D catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 2871769..2872806 Mycobacterium leprae TN 908605 NP_302555.1 CDS ML2402 NC_002677.1 2872831 2873604 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2872831..2873604 Mycobacterium leprae TN 908604 NP_302556.1 CDS ML2406 NC_002677.1 2877398 2878282 D catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 2877398..2878282 Mycobacterium leprae TN 908601 NP_302557.1 CDS ML2407 NC_002677.1 2878350 2878685 R hypothetical protein complement(2878350..2878685) Mycobacterium leprae TN 908224 NP_302558.1 CDS ML2409 NC_002677.1 2880041 2881024 R cytochrome C biogenesis protein complement(2880041..2881024) Mycobacterium leprae TN 908580 NP_302559.1 CDS ML2410 NC_002677.1 2881021 2882649 R hypothetical protein complement(2881021..2882649) Mycobacterium leprae TN 908437 NP_302560.1 CDS ML2411 NC_002677.1 2882646 2883434 R cytochrome C-type biogenesis protein complement(2882646..2883434) Mycobacterium leprae TN 908597 NP_302561.1 CDS ML2412 NC_002677.1 2883431 2884099 R hypothetical protein complement(2883431..2884099) Mycobacterium leprae TN 908433 NP_302562.1 CDS ML2413 NC_002677.1 2884096 2884704 R phosphoglycerate mutase complement(2884096..2884704) Mycobacterium leprae TN 908591 NP_302563.1 CDS hemL NC_002677.1 2884704 2886044 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(2884704..2886044) Mycobacterium leprae TN 908589 NP_302564.1 CDS hemB NC_002677.1 2893799 2894788 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(2893799..2894788) Mycobacterium leprae TN 908581 NP_302565.1 CDS hemD NC_002677.1 2894835 2896526 R uroporphyrin-III C-methyltransferase complement(2894835..2896526) Mycobacterium leprae TN 908323 NP_302566.1 CDS hemC NC_002677.1 2896533 2897489 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(2896533..2897489) Mycobacterium leprae TN 908457 NP_302567.1 CDS hemA NC_002677.1 2897494 2898897 R catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase complement(2897494..2898897) Mycobacterium leprae TN 909785 NP_302568.1 CDS ML2424 NC_002677.1 2899999 2900901 D hypothetical protein 2899999..2900901 Mycobacterium leprae TN 908575 NP_302569.1 CDS ML2425 NC_002677.1 2901005 2901505 D hypothetical protein 2901005..2901505 Mycobacterium leprae TN 909327 NP_302570.1 CDS cmaA2 NC_002677.1 2901516 2902442 D cyclopropane mycolic acid synthase 2901516..2902442 Mycobacterium leprae TN 908573 NP_302571.1 CDS ML2427 NC_002677.1 2902471 2903583 R hypothetical protein complement(2902471..2903583) Mycobacterium leprae TN 908458 NP_302572.1 CDS ML2428 NC_002677.1 2903580 2904674 R glucose epimerase/dehydratase complement(2903580..2904674) Mycobacterium leprae TN 908362 NP_302573.1 CDS ML2428A NC_002677.1 2904745 2904846 R hypothetical protein complement(2904745..2904846) Mycobacterium leprae TN 908568 NP_302574.1 CDS ML2429 NC_002677.1 2905089 2905349 R DNA-binding protein complement(2905089..2905349) Mycobacterium leprae TN 908567 NP_302575.1 CDS proC NC_002677.1 2905490 2906374 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(2905490..2906374) Mycobacterium leprae TN 908565 NP_302576.1 CDS ML2432 NC_002677.1 2907135 2907977 R hypothetical protein complement(2907135..2907977) Mycobacterium leprae TN 908559 NP_302577.1 CDS ML2433 NC_002677.1 2908008 2909075 R hypothetical protein complement(2908008..2909075) Mycobacterium leprae TN 909235 NP_302578.1 CDS ML2434 NC_002677.1 2909072 2910091 R hypothetical protein complement(2909072..2910091) Mycobacterium leprae TN 908558 NP_302579.1 CDS ML2435 NC_002677.1 2910195 2911028 D hypothetical protein 2910195..2911028 Mycobacterium leprae TN 908552 NP_302580.1 CDS ML2439 NC_002677.1 2914489 2915085 R two-component system response regulator complement(2914489..2915085) Mycobacterium leprae TN 908548 NP_302581.1 CDS ML2440 NC_002677.1 2915128 2916453 R two-component system sensor histidine kinase complement(2915128..2916453) Mycobacterium leprae TN 908546 NP_302582.1 CDS gpmA NC_002677.1 2916616 2917359 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(2916616..2917359) Mycobacterium leprae TN 908545 NP_302583.1 CDS ML2442 NC_002677.1 2917372 2917926 R hypothetical protein complement(2917372..2917926) Mycobacterium leprae TN 908544 NP_302584.1 CDS ML2443 NC_002677.1 2918000 2919286 R glycosyl transferase family protein complement(2918000..2919286) Mycobacterium leprae TN 908203 NP_302585.1 CDS ML2446 NC_002677.1 2921383 2922708 R lipoprotein complement(2921383..2922708) Mycobacterium leprae TN 908347 NP_302586.1 CDS murB NC_002677.1 2922789 2923892 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(2922789..2923892) Mycobacterium leprae TN 908302 NP_302587.1 CDS ML2449 NC_002677.1 2924641 2925456 D hydrolase 2924641..2925456 Mycobacterium leprae TN 908531 NP_302588.1 CDS ML2450 NC_002677.1 2925762 2926499 D hypothetical protein 2925762..2926499 Mycobacterium leprae TN 908371 NP_302589.1 CDS deoC NC_002677.1 2926556 2927236 R catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase complement(2926556..2927236) Mycobacterium leprae TN 908530 NP_302590.1 CDS ML2452 NC_002677.1 2927236 2927607 R hypothetical protein complement(2927236..2927607) Mycobacterium leprae TN 908528 NP_302591.1 CDS ML2453 NC_002677.1 2927710 2927997 R hypothetical protein complement(2927710..2927997) Mycobacterium leprae TN 909786 NP_302592.1 CDS ML2454 NC_002677.1 2928117 2928683 R hemagglutinin complement(2928117..2928683) Mycobacterium leprae TN 908523 NP_302593.1 CDS ML2457 NC_002677.1 2930178 2930879 D TetR family transcriptional regulator 2930178..2930879 Mycobacterium leprae TN 908519 NP_302594.1 CDS umaA2 NC_002677.1 2932062 2932949 D mycolic acid synthase 2932062..2932949 Mycobacterium leprae TN 908512 NP_302595.1 CDS fadB2 NC_002677.1 2934086 2934949 R converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase complement(2934086..2934949) Mycobacterium leprae TN 908515 NP_302596.1 CDS ML2463 NC_002677.1 2936751 2937545 R hypothetical protein complement(2936751..2937545) Mycobacterium leprae TN 908229 NP_302597.1 CDS ML2465 NC_002677.1 2939177 2939743 D hypothetical protein 2939177..2939743 Mycobacterium leprae TN 908595 NP_302598.1 CDS ML2467 NC_002677.1 2940904 2941692 D undecaprenyl pyrophosphate synthetase 2940904..2941692 Mycobacterium leprae TN 908506 NP_302599.1 CDS ML2468 NC_002677.1 2942027 2942407 R hypothetical protein complement(2942027..2942407) Mycobacterium leprae TN 908164 NP_302600.1 CDS ML2472 NC_002677.1 2947158 2948141 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(2947158..2948141) Mycobacterium leprae TN 908169 NP_302601.1 CDS ML2473 NC_002677.1 2948272 2948751 D hypothetical protein 2948272..2948751 Mycobacterium leprae TN 908518 NP_302602.1 CDS ML2474 NC_002677.1 2948766 2949281 D cytidine/deoxycytidylate deaminase 2948766..2949281 Mycobacterium leprae TN 908496 NP_302603.1 CDS ML2476 NC_002677.1 2950639 2950806 R hypothetical protein complement(2950639..2950806) Mycobacterium leprae TN 908488 NP_302604.1 CDS ML2478 NC_002677.1 2952757 2953146 R hypothetical protein complement(2952757..2953146) Mycobacterium leprae TN 908487 NP_302605.1 CDS ML2485 NC_002677.1 2959460 2960008 R RNA methyltransferase complement(2959460..2960008) Mycobacterium leprae TN 908219 NP_302606.1 CDS pyrE NC_002677.1 2961000 2961539 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(2961000..2961539) Mycobacterium leprae TN 908475 NP_302607.1 CDS ML2489 NC_002677.1 2962275 2963135 R hypothetical protein complement(2962275..2963135) Mycobacterium leprae TN 908170 NP_302608.1 CDS clpB NC_002677.1 2963220 2965766 R heat shock protein complement(2963220..2965766) Mycobacterium leprae TN 908472 NP_302609.1 CDS ML2491 NC_002677.1 2966697 2967698 D hypothetical protein 2966697..2967698 Mycobacterium leprae TN 908469 NP_302610.1 CDS hspR NC_002677.1 2969298 2969696 R heat shock regulator complement(2969298..2969696) Mycobacterium leprae TN 908468 NP_302611.1 CDS dnaJ NC_002677.1 2969700 2970866 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ complement(2969700..2970866) Mycobacterium leprae TN 908467 NP_302612.1 CDS grpE NC_002677.1 2970880 2971569 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2970880..2971569) Mycobacterium leprae TN 908465 NP_302613.1 CDS dnaK NC_002677.1 2971566 2973428 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(2971566..2973428) Mycobacterium leprae TN 908588 NP_302614.1 CDS ML2497 NC_002677.1 2974117 2974590 D hypothetical protein 2974117..2974590 Mycobacterium leprae TN 908462 NP_302615.1 CDS ML2498 NC_002677.1 2974620 2975279 D enoyl-CoA hydratase 2974620..2975279 Mycobacterium leprae TN 908304 NP_302616.1 CDS ML2501 NC_002677.1 2980181 2982823 D iron-sulfur-binding reductase 2980181..2982823 Mycobacterium leprae TN 908459 NP_302617.1 CDS ML2502 NC_002677.1 2982832 2984145 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2982832..2984145 Mycobacterium leprae TN 908455 NP_302618.1 CDS rfbA NC_002677.1 2984300 2985166 R glucose-1-phosphate thymidylyltransferase complement(2984300..2985166) Mycobacterium leprae TN 908452 NP_302619.1 CDS dcd NC_002677.1 2987949 2988521 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2987949..2988521) Mycobacterium leprae TN 910802 NP_302620.1 CDS ML2518 NC_002677.1 2999816 3000208 R hypothetical protein complement(2999816..3000208) Mycobacterium leprae TN 908440 NP_302621.1 CDS ML2522 NC_002677.1 3004590 3005246 R hypothetical protein complement(3004590..3005246) Mycobacterium leprae TN 910807 NP_302622.1 CDS ML2527 NC_002677.1 3009256 3010275 R hypothetical protein complement(3009256..3010275) Mycobacterium leprae TN 908427 NP_302623.1 CDS ML2528 NC_002677.1 3010272 3011699 R protease complement(3010272..3011699) Mycobacterium leprae TN 910803 NP_302624.1 CDS ML2529 NC_002677.1 3011710 3013167 R hypothetical protein complement(3011710..3013167) Mycobacterium leprae TN 910804 NP_302625.1 CDS ML2530 NC_002677.1 3013309 3014178 R DNA-binding protein complement(3013309..3014178) Mycobacterium leprae TN 908426 NP_302626.1 CDS ML2531 NC_002677.1 3014189 3014479 R cell surface protein complement(3014189..3014479) Mycobacterium leprae TN 908479 NP_302627.1 CDS ML2532 NC_002677.1 3014518 3014814 R PE-family protein complement(3014518..3014814) Mycobacterium leprae TN 908424 NP_302628.1 CDS ML2534 NC_002677.1 3016103 3016411 R PE-family protein complement(3016103..3016411) Mycobacterium leprae TN 910907 NP_302629.1 CDS ML2535 NC_002677.1 3016446 3020435 R hypothetical protein complement(3016446..3020435) Mycobacterium leprae TN 908421 NP_302630.1 CDS ML2536 NC_002677.1 3020432 3022090 R hypothetical protein complement(3020432..3022090) Mycobacterium leprae TN 910905 NP_302631.1 CDS ML2537 NC_002677.1 3022083 3024005 R hypothetical protein complement(3022083..3024005) Mycobacterium leprae TN 908418 NP_302632.1 CDS fadD2 NC_002677.1 3033660 3035306 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3033660..3035306) Mycobacterium leprae TN 910899 NP_302633.1 CDS ML2549 NC_002677.1 3037538 3038206 D hypothetical protein 3037538..3038206 Mycobacterium leprae TN 908412 NP_302634.1 CDS ML2550 NC_002677.1 3038228 3039145 D hypothetical protein 3038228..3039145 Mycobacterium leprae TN 910897 NP_302635.1 CDS aac NC_002677.1 3039192 3039740 D aminoglycoside 2'-N-acetyltransferase 3039192..3039740 Mycobacterium leprae TN 908410 NP_302636.1 CDS ML2557 NC_002677.1 3049294 3049590 D hypothetical protein 3049294..3049590 Mycobacterium leprae TN 910893 NP_302637.1 CDS ML2561 NC_002677.1 3053222 3053710 R oxidoreductase complement(3053222..3053710) Mycobacterium leprae TN 910892 NP_302638.1 CDS ML2562 NC_002677.1 3054587 3054877 D hypothetical protein 3054587..3054877 Mycobacterium leprae TN 908401 NP_302639.1 CDS fadE5 NC_002677.1 3055229 3057064 D acyl-CoA dehydrogenase 3055229..3057064 Mycobacterium leprae TN 908400 NP_302640.1 CDS fadA2 NC_002677.1 3057486 3058859 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(3057486..3058859) Mycobacterium leprae TN 910891 NP_302641.1 CDS fabG NC_002677.1 3058964 3060328 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3058964..3060328 Mycobacterium leprae TN 908398 NP_302642.1 CDS ML2566 NC_002677.1 3061369 3062271 D hypothetical protein 3061369..3062271 Mycobacterium leprae TN 908394 NP_302643.1 CDS ML2567 NC_002677.1 3062380 3062859 D hypothetical protein 3062380..3062859 Mycobacterium leprae TN 910889 NP_302644.1 CDS ML2568 NC_002677.1 3063262 3063888 R TetR family transcriptional regulator complement(3063262..3063888) Mycobacterium leprae TN 908390 NP_302645.1 CDS ML2569 NC_002677.1 3063958 3065121 R glycosyl hydrolase complement(3063958..3065121) Mycobacterium leprae TN 908389 NP_302646.1 CDS ML2569A NC_002677.1 3065268 3065441 D hypothetical protein 3065268..3065441 Mycobacterium leprae TN 910887 NP_302647.1 CDS ML2570 NC_002677.1 3065557 3069774 D hypothetical protein 3065557..3069774 Mycobacterium leprae TN 908387 NP_302648.1 CDS gabD1 NC_002677.1 3072684 3074057 D NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 3072684..3074057 Mycobacterium leprae TN 910883 NP_302649.1 CDS ML2580 NC_002677.1 3080175 3081329 R acyltransferase complement(3080175..3081329) Mycobacterium leprae TN 910886 NP_302650.1 CDS ML2581 NC_002677.1 3081538 3082821 D hypothetical protein 3081538..3082821 Mycobacterium leprae TN 910878 NP_302651.1 CDS ML2582 NC_002677.1 3082923 3084725 D hypothetical protein 3082923..3084725 Mycobacterium leprae TN 908377 NP_302652.1 CDS ML2583 NC_002677.1 3085088 3086272 R glycosyl transferase family protein complement(3085088..3086272) Mycobacterium leprae TN 910885 NP_302653.1 CDS ML2584 NC_002677.1 3086325 3087134 D hypothetical protein 3086325..3087134 Mycobacterium leprae TN 910879 NP_302654.1 CDS yrbE1A NC_002677.1 3090766 3091569 D hypothetical protein 3090766..3091569 Mycobacterium leprae TN 910875 NP_302655.1 CDS yrbE1B NC_002677.1 3091573 3092442 D hypothetical protein 3091573..3092442 Mycobacterium leprae TN 908358 NP_302656.1 CDS mce1A NC_002677.1 3092446 3093771 D cell invasion protein 3092446..3093771 Mycobacterium leprae TN 910890 NP_302657.1 CDS mce1B NC_002677.1 3093768 3094808 D hypothetical protein 3093768..3094808 Mycobacterium leprae TN 908355 NP_302658.1 CDS mce1C NC_002677.1 3094805 3096364 D hypothetical protein 3094805..3096364 Mycobacterium leprae TN 910873 NP_302659.1 CDS mce1D NC_002677.1 3096361 3097956 D hypothetical protein 3096361..3097956 Mycobacterium leprae TN 908354 NP_302660.1 CDS lprK NC_002677.1 3097953 3099131 D lipoprotein 3097953..3099131 Mycobacterium leprae TN 908351 NP_302661.1 CDS mce1F NC_002677.1 3099125 3100675 D hypothetical protein 3099125..3100675 Mycobacterium leprae TN 908342 NP_302662.1 CDS ML2595 NC_002677.1 3100808 3101356 D hypothetical protein 3100808..3101356 Mycobacterium leprae TN 910876 NP_302663.1 CDS ML2596 NC_002677.1 3101353 3102330 D hypothetical protein 3101353..3102330 Mycobacterium leprae TN 908340 NP_302664.1 CDS ML2597 NC_002677.1 3102327 3102881 D hypothetical protein 3102327..3102881 Mycobacterium leprae TN 910872 NP_302665.1 CDS ML2598 NC_002677.1 3102971 3103525 D hypothetical protein 3102971..3103525 Mycobacterium leprae TN 910874 NP_302666.1 CDS ML2600 NC_002677.1 3104660 3106057 R hypothetical protein complement(3104660..3106057) Mycobacterium leprae TN 910869 NP_302667.1 CDS ML2603 NC_002677.1 3107546 3108385 D hypothetical protein 3107546..3108385 Mycobacterium leprae TN 910871 NP_302668.1 CDS ML2604 NC_002677.1 3108446 3109195 D hypothetical protein 3108446..3109195 Mycobacterium leprae TN 908331 NP_302669.1 CDS ML2605 NC_002677.1 3109192 3109698 D hypothetical protein 3109192..3109698 Mycobacterium leprae TN 910867 NP_302670.1 CDS ilvD NC_002677.1 3113024 3114718 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(3113024..3114718) Mycobacterium leprae TN 910866 NP_302671.1 CDS ML2609 NC_002677.1 3114782 3115189 D hypothetical protein 3114782..3115189 Mycobacterium leprae TN 908329 NP_302672.1 CDS ML2613 NC_002677.1 3118765 3120768 R zinc metalloprotease complement(3118765..3120768) Mycobacterium leprae TN 908327 NP_302673.1 CDS ML2614 NC_002677.1 3120828 3121502 D hypothetical protein 3120828..3121502 Mycobacterium leprae TN 910861 NP_302674.1 CDS ML2615 NC_002677.1 3121499 3122188 D hypothetical protein 3121499..3122188 Mycobacterium leprae TN 908325 NP_302675.1 CDS ML2616 NC_002677.1 3122267 3122779 R hypothetical protein complement(3122267..3122779) Mycobacterium leprae TN 910859 NP_302676.1 CDS ML2617 NC_002677.1 3122776 3125817 R hypothetical protein complement(3122776..3125817) Mycobacterium leprae TN 910858 NP_302677.1 CDS ML2618 NC_002677.1 3126434 3127492 R hypothetical protein complement(3126434..3127492) Mycobacterium leprae TN 910860 NP_302678.1 CDS ML2620 NC_002677.1 3128833 3131700 R hypothetical protein complement(3128833..3131700) Mycobacterium leprae TN 910862 NP_302679.1 CDS ML2621 NC_002677.1 3131780 3132367 R Some; hypothetical protein complement(3131780..3132367) Mycobacterium leprae TN 910863 NP_302680.1 CDS trmB NC_002677.1 3132576 3133268 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3132576..3133268) Mycobacterium leprae TN 910881 NP_302681.1 CDS pckA NC_002677.1 3135274 3137103 D catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 3135274..3137103 Mycobacterium leprae TN 910856 NP_302682.1 CDS ML2627 NC_002677.1 3140261 3141280 D hypothetical protein 3140261..3141280 Mycobacterium leprae TN 908319 NP_302683.1 CDS ML2629 NC_002677.1 3144572 3145042 R hypothetical protein complement(3144572..3145042) Mycobacterium leprae TN 910855 NP_302684.1 CDS ML2630 NC_002677.1 3145226 3145597 R hypothetical protein complement(3145226..3145597) Mycobacterium leprae TN 910851 NP_302685.1 CDS ML2631 NC_002677.1 3147695 3149044 R oxidoreductase complement(3147695..3149044) Mycobacterium leprae TN 908317 NP_302686.1 CDS pntB NC_002677.1 3151464 3152882 R [beta]; pyridine transhydrogenase subunit complement(3151464..3152882) Mycobacterium leprae TN 908314 NP_302687.1 CDS pntAB NC_002677.1 3152879 3153217 R pyridine transhydrogenase subunit [alpha]2 complement(3152879..3153217) Mycobacterium leprae TN 910853 NP_302688.1 CDS pntAA NC_002677.1 3153210 3154313 R pyridine transhydrogenase subunit [alpha]1 complement(3153210..3154313) Mycobacterium leprae TN 908312 NP_302689.1 CDS ML2639 NC_002677.1 3157362 3158867 R aldehyde dehydrogenase complement(3157362..3158867) Mycobacterium leprae TN 908307 NP_302690.1 CDS ML2640 NC_002677.1 3159055 3159987 R hypothetical protein complement(3159055..3159987) Mycobacterium leprae TN 910852 NP_302691.1 CDS ML2647 NC_002677.1 3166865 3167398 D this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 3166865..3167398 Mycobacterium leprae TN 908295 NP_302692.1 CDS ML2649 NC_002677.1 3169324 3170139 R hypothetical protein complement(3169324..3170139) Mycobacterium leprae TN 910845 NP_302693.1 CDS ML2651 NC_002677.1 3173289 3173606 D hypothetical protein 3173289..3173606 Mycobacterium leprae TN 908292 NP_302694.1 CDS ML2654 NC_002677.1 3176727 3177224 D hypothetical protein 3176727..3177224 Mycobacterium leprae TN 910844 NP_302695.1 CDS fbpC2 NC_002677.1 3177813 3178814 D antigen 85A, mycolyltransferase 3177813..3178814 Mycobacterium leprae TN 910842 NP_302696.1 CDS ML2659 NC_002677.1 3182074 3183138 R serine protease complement(3182074..3183138) Mycobacterium leprae TN 908288 NP_302697.1 CDS ML2661 NC_002677.1 3185860 3187506 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3185860..3187506) Mycobacterium leprae TN 908287 NP_302698.1 CDS oxyS NC_002677.1 3189375 3190307 R LysR family transcriptional regulator complement(3189375..3190307) Mycobacterium leprae TN 908284 NP_302699.1 CDS ML2664 NC_002677.1 3190775 3191530 D hypothetical protein 3190775..3191530 Mycobacterium leprae TN 908283 NP_302700.1 CDS ML2666 NC_002677.1 3193706 3193960 R hypothetical protein complement(3193706..3193960) Mycobacterium leprae TN 908282 NP_302701.1 CDS ML2667 NC_002677.1 3194549 3196405 R membrane transporter complement(3194549..3196405) Mycobacterium leprae TN 910834 NP_302702.1 CDS ML2669 NC_002677.1 3197427 3197747 D hypothetical protein 3197427..3197747 Mycobacterium leprae TN 910833 NP_302703.1 CDS ML2670 NC_002677.1 3197961 3199961 R hypothetical protein complement(3197961..3199961) Mycobacterium leprae TN 908280 NP_302704.1 CDS ML2671 NC_002677.1 3204710 3209539 D cation transport ATPase 3204710..3209539 Mycobacterium leprae TN 910835 NP_302705.1 CDS icd2 NC_002677.1 3210647 3212887 R [NADP]; isocitrate dehydrogenase complement(3210647..3212887) Mycobacterium leprae TN 910837 NP_302706.1 CDS ML2677 NC_002677.1 3221695 3222405 D TetR family transcriptional regulator 3221695..3222405 Mycobacterium leprae TN 910830 NP_302707.1 CDS ML2678 NC_002677.1 3222402 3225404 D hypothetical protein 3222402..3225404 Mycobacterium leprae TN 910831 NP_302708.1 CDS ML2679 NC_002677.1 3225401 3228082 D hypothetical protein 3225401..3228082 Mycobacterium leprae TN 908273 NP_302709.1 CDS dnaB NC_002677.1 3230314 3232128 R replicative DNA helicase complement(3230314..3232128) Mycobacterium leprae TN 910801 NP_302710.1 CDS rplI NC_002677.1 3232678 3233136 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(3232678..3233136) Mycobacterium leprae TN 908270 NP_302711.1 CDS rpsR NC_002677.1 3233184 3233438 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(3233184..3233438) Mycobacterium leprae TN 910829 NP_302712.1 CDS ssb NC_002677.1 3233464 3233970 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(3233464..3233970) Mycobacterium leprae TN 908269 NP_302713.1 CDS rpsF NC_002677.1 3234130 3234420 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(3234130..3234420) Mycobacterium leprae TN 910827 NP_302714.1 CDS ML2687 NC_002677.1 3234968 3236662 R hypothetical protein complement(3234968..3236662) Mycobacterium leprae TN 910826 NP_302715.1 CDS ponA NC_002677.1 3236659 3238785 R penicillin-bonding protein complement(3236659..3238785) Mycobacterium leprae TN 908266 NP_302716.1 CDS ML2689 NC_002677.1 3239183 3239599 R hypothetical protein complement(3239183..3239599) Mycobacterium leprae TN 910824 NP_302717.1 CDS ML2691 NC_002677.1 3240798 3241340 D hypothetical protein 3240798..3241340 Mycobacterium leprae TN 910823 NP_302718.1 CDS ML2692 NC_002677.1 3241421 3242530 D hypothetical protein 3241421..3242530 Mycobacterium leprae TN 908264 NP_302719.1 CDS ML2696 NC_002677.1 3246782 3247513 D MarR family transcriptional regulator 3246782..3247513 Mycobacterium leprae TN 910822 NP_302720.1 CDS pcnA NC_002677.1 3248268 3249728 R hypothetical protein complement(3248268..3249728) Mycobacterium leprae TN 908259 NP_302721.1 CDS ML2698 NC_002677.1 3249915 3250670 D hypothetical protein 3249915..3250670 Mycobacterium leprae TN 908257 NP_302722.1 CDS ML2699 NC_002677.1 3250667 3253060 D hypothetical protein 3250667..3253060 Mycobacterium leprae TN 910820 NP_302723.1 CDS ML2700 NC_002677.1 3253057 3256677 D hypothetical protein 3253057..3256677 Mycobacterium leprae TN 908256 NP_302724.1 CDS trxB NC_002677.1 3258250 3259626 D thioredoxin; bifunctional thioredoxin reductase/thioredoxin 3258250..3259626 Mycobacterium leprae TN 910819 NP_302725.1 CDS ML2704 NC_002677.1 3259759 3260979 D hydrolase 3259759..3260979 Mycobacterium leprae TN 908251 NP_302726.1 CDS ML2705 NC_002677.1 3260976 3261755 R hypothetical protein complement(3260976..3261755) Mycobacterium leprae TN 908250 NP_302727.1 CDS parB NC_002677.1 3262108 3263115 R cell division protein complement(3262108..3263115) Mycobacterium leprae TN 910817 NP_302728.1 CDS parA NC_002677.1 3263112 3264167 R cell division protein complement(3263112..3264167) Mycobacterium leprae TN 910816 NP_302729.1 CDS gidB NC_002677.1 3264164 3264910 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(3264164..3264910) Mycobacterium leprae TN 910815 NP_302730.1 CDS ML2709 NC_002677.1 3264982 3265563 R hypothetical protein complement(3264982..3265563) Mycobacterium leprae TN 908249 NP_302731.1 CDS ML2710 NC_002677.1 3265645 3266787 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC complement(3265645..3266787) Mycobacterium leprae TN 908248 NP_302732.1 CDS rnpA NC_002677.1 3267126 3267488 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(3267126..3267488) Mycobacterium leprae TN 908246 NP_302733.1 CDS rpmH NC_002677.1 3267510 3267653 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(3267510..3267653) Mycobacterium leprae TN 910818 MLt01 tRNA ileT NC_002677.1 12194 12270 D tRNA-Ile 12194..12270 Mycobacterium leprae TN 908161 MLt02 tRNA alaT NC_002677.1 12404 12479 D tRNA-Ala 12404..12479 Mycobacterium leprae TN 910206 MLt03 tRNA leuT NC_002677.1 28890 28972 D tRNA-Leu 28890..28972 Mycobacterium leprae TN 908181 MLt04 tRNA serU NC_002677.1 160312 160401 D tRNA-Ser 160312..160401 Mycobacterium leprae TN 908379 MLt05 tRNA serT NC_002677.1 165035 165127 D tRNA-Ser 165035..165127 Mycobacterium leprae TN 908397 MLt06 tRNA argU NC_002677.1 165147 165219 D tRNA-Arg 165147..165219 Mycobacterium leprae TN 908402 MLt07 tRNA alaV NC_002677.1 251305 251377 D tRNA-Ala 251305..251377 Mycobacterium leprae TN 908572 MLt08 tRNA thrU NC_002677.1 271901 271976 D tRNA-Thr 271901..271976 Mycobacterium leprae TN 908613 MLt09 tRNA glnT NC_002677.1 326132 326203 R tRNA-Gln complement(326132..326203) Mycobacterium leprae TN 908743 MLt10 tRNA leuX NC_002677.1 344340 344413 D tRNA-Leu 344340..344413 Mycobacterium leprae TN 908770 MLt11 tRNA lysU NC_002677.1 524675 524750 R tRNA-Lys complement(524675..524750) Mycobacterium leprae TN 909168 MLt12 tRNA hisT NC_002677.1 526168 526243 R tRNA-His complement(526168..526243) Mycobacterium leprae TN 909170 MLt13 tRNA metU NC_002677.1 780284 780360 D tRNA-Met 780284..780360 Mycobacterium leprae TN 909430 MLt14 tRNA asnT NC_002677.1 990844 990916 D tRNA-Asn 990844..990916 Mycobacterium leprae TN 909796 MLt15 tRNA argV NC_002677.1 1316300 1316375 R tRNA-Arg complement(1316300..1316375) Mycobacterium leprae TN 910219 MLt16 tRNA leuW NC_002677.1 1374076 1374158 D tRNA-Leu 1374076..1374158 Mycobacterium leprae TN 910276 MLt17 tRNA argW NC_002677.1 1481448 1481521 R tRNA-Arg complement(1481448..1481521) Mycobacterium leprae TN 910349 MLt18 tRNA leuV NC_002677.1 1531698 1531774 R tRNA-Leu complement(1531698..1531774) Mycobacterium leprae TN 910535 MLt19 tRNA leuU NC_002677.1 1535951 1536036 R tRNA-Leu complement(1535951..1536036) Mycobacterium leprae TN 910400 MLt20 tRNA valU NC_002677.1 1602376 1602450 R tRNA-Val complement(1602376..1602450) Mycobacterium leprae TN 910465 MLt21 tRNA cysU NC_002677.1 1602465 1602538 R tRNA-Cys complement(1602465..1602538) Mycobacterium leprae TN 910471 MLt22 tRNA glyT NC_002677.1 1602564 1602639 R tRNA-Gly complement(1602564..1602639) Mycobacterium leprae TN 910472 MLt23 tRNA valT NC_002677.1 1602818 1602892 D tRNA-Val 1602818..1602892 Mycobacterium leprae TN 910475 MLt24 tRNA proT NC_002677.1 1638366 1638442 D tRNA-Pro 1638366..1638442 Mycobacterium leprae TN 910504 MLt25 tRNA proU NC_002677.1 1785013 1785089 R tRNA-Pro complement(1785013..1785089) Mycobacterium leprae TN 909510 MLt26 tRNA glyV NC_002677.1 1785225 1785295 D tRNA-Gly 1785225..1785295 Mycobacterium leprae TN 909511 MLt27 tRNA valV NC_002677.1 1987240 1987314 R tRNA-Val complement(1987240..1987314) Mycobacterium leprae TN 909954 MLt28 tRNA gluU NC_002677.1 2033106 2033181 R tRNA-Glu complement(2033106..2033181) Mycobacterium leprae TN 910056 MLt29 tRNA glnU NC_002677.1 2033269 2033343 R tRNA-Gln complement(2033269..2033343) Mycobacterium leprae TN 910057 MLt30 tRNA alaU NC_002677.1 2133844 2133919 R tRNA-Ala complement(2133844..2133919) Mycobacterium leprae TN 910734 MLt31 tRNA metV NC_002677.1 2135494 2135567 R tRNA-Met complement(2135494..2135567) Mycobacterium leprae TN 910732 MLt32 tRNA trpT NC_002677.1 2292901 2292973 R tRNA-Trp complement(2292901..2292973) Mycobacterium leprae TN 910582 MLt33 tRNA metT NC_002677.1 2294800 2294876 R tRNA-Met complement(2294800..2294876) Mycobacterium leprae TN 910577 MLt34 tRNA thrT NC_002677.1 2294930 2295002 R tRNA-Thr complement(2294930..2295002) Mycobacterium leprae TN 910576 MLt35 tRNA argT NC_002677.1 2506601 2506673 D tRNA-Arg 2506601..2506673 Mycobacterium leprae TN 909024 MLt36 tRNA pheU NC_002677.1 2594578 2594654 R tRNA-Phe complement(2594578..2594654) Mycobacterium leprae TN 908857 MLt37 tRNA aspT NC_002677.1 2594683 2594759 R tRNA-Asp complement(2594683..2594759) Mycobacterium leprae TN 908856 MLt38 tRNA gluT NC_002677.1 2594790 2594862 R tRNA-Glu complement(2594790..2594862) Mycobacterium leprae TN 908855 MLt39 tRNA lysT NC_002677.1 2594986 2595058 D tRNA-Lys 2594986..2595058 Mycobacterium leprae TN 908854 MLt40 tRNA thrV NC_002677.1 2659692 2659766 D tRNA-Thr 2659692..2659766 Mycobacterium leprae TN 908380 MLt41 tRNA tyrT NC_002677.1 2707385 2707468 D tRNA-Tyr 2707385..2707468 Mycobacterium leprae TN 908740 MLt42 tRNA proY NC_002677.1 2736797 2736870 D tRNA-Pro 2736797..2736870 Mycobacterium leprae TN 908718 MLt43 tRNA serV NC_002677.1 2769253 2769338 D tRNA-Ser 2769253..2769338 Mycobacterium leprae TN 908698 MLt44 tRNA serX NC_002677.1 2949298 2949388 D tRNA-Ser 2949298..2949388 Mycobacterium leprae TN 908395 MLt45 tRNA glyU NC_002677.1 2989356 2989429 D tRNA-Gly 2989356..2989429 Mycobacterium leprae TN 908649 MLr01 rRNA rrs NC_002677.1 1341144 1342692 D 16S ribosomal RNA 1341144..1342692 Mycobacterium leprae TN 910245 MLr02 rRNA rrl NC_002677.1 1342976 1346100 D 23S ribosomal RNA 1342976..1346100 Mycobacterium leprae TN 910246 MLr03 rRNA rrf NC_002677.1 1346186 1346301 D 5S ribosomal RNA 1346186..1346301 Mycobacterium leprae TN 910247