-- dump date 20140619_152948 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272631000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 272631000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631000003 Walker A motif; other site 272631000004 ATP binding site [chemical binding]; other site 272631000005 Walker B motif; other site 272631000006 arginine finger; other site 272631000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272631000008 DnaA box-binding interface [nucleotide binding]; other site 272631000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 272631000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272631000011 putative DNA binding surface [nucleotide binding]; other site 272631000012 dimer interface [polypeptide binding]; other site 272631000013 beta-clamp/clamp loader binding surface; other site 272631000014 beta-clamp/translesion DNA polymerase binding surface; other site 272631000015 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 272631000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 272631000017 Walker A/P-loop; other site 272631000018 ATP binding site [chemical binding]; other site 272631000019 Q-loop/lid; other site 272631000020 ABC transporter signature motif; other site 272631000021 Walker B; other site 272631000022 D-loop; other site 272631000023 H-loop/switch region; other site 272631000024 hypothetical protein; Provisional; Region: PRK03195 272631000025 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272631000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272631000027 ATP binding site [chemical binding]; other site 272631000028 Mg2+ binding site [ion binding]; other site 272631000029 G-X-G motif; other site 272631000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272631000031 anchoring element; other site 272631000032 dimer interface [polypeptide binding]; other site 272631000033 ATP binding site [chemical binding]; other site 272631000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272631000035 active site 272631000036 metal binding site [ion binding]; metal-binding site 272631000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272631000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272631000039 CAP-like domain; other site 272631000040 active site 272631000041 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272631000042 protein-splicing catalytic site; other site 272631000043 thioester formation/cholesterol transfer; other site 272631000044 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 272631000045 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 272631000046 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 272631000047 DNA gyrase subunit A; Validated; Region: PRK05560 272631000048 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272631000049 primary dimer interface [polypeptide binding]; other site 272631000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272631000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272631000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272631000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272631000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272631000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272631000056 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 272631000057 hypothetical protein (pseudogene) 272631000058 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272631000059 active site 272631000060 Bacterial PH domain; Region: bPH_6; pfam10756 272631000061 putative septation inhibitor protein; Reviewed; Region: PRK00159 272631000062 possible cell division protein (pseudogene) 272631000063 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272631000064 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272631000065 glutamine binding [chemical binding]; other site 272631000066 catalytic triad [active] 272631000067 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272631000068 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272631000069 active site 272631000070 ATP binding site [chemical binding]; other site 272631000071 substrate binding site [chemical binding]; other site 272631000072 activation loop (A-loop); other site 272631000073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 272631000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272631000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272631000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272631000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272631000078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272631000079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272631000080 active site 272631000081 ATP binding site [chemical binding]; other site 272631000082 substrate binding site [chemical binding]; other site 272631000083 activation loop (A-loop); other site 272631000084 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272631000085 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272631000086 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 272631000087 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272631000088 active site 272631000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272631000090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272631000091 phosphopeptide binding site; other site 272631000092 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 272631000093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272631000094 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272631000095 phosphopeptide binding site; other site 272631000096 PPE-family protein (pseudogene) 272631000097 probable membrane protein (pseudogene) 272631000098 hypothetical protein; Validated; Region: PRK00228 272631000099 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 272631000100 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 272631000101 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272631000102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272631000103 active site 272631000104 HIGH motif; other site 272631000105 nucleotide binding site [chemical binding]; other site 272631000106 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272631000107 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272631000108 active site 272631000109 KMSKS motif; other site 272631000110 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272631000111 tRNA binding surface [nucleotide binding]; other site 272631000112 conserved hypothetical protein (pseudogene) 272631000113 hypothetical protein (pseudogene) 272631000114 conserved hypothetical protein (pseudogene) 272631000115 probable membrane protein (pseudogene) 272631000116 protease (pseudogene) 272631000117 hypothetical protein (pseudogene) 272631000118 conserved hypothetical protein (pseudogene) 272631000119 transposase remnant 272631000120 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272631000121 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 272631000122 active site 272631000123 catalytic residues [active] 272631000124 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 272631000125 conserved hypothetical protein (pseudogene) 272631000126 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 272631000127 hypothetical protein (pseudogene) 272631000128 hypothetical protein (pseudogene) 272631000129 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 272631000130 RAM signalling pathway protein; Region: SOG2; pfam10428 272631000131 hypothetical protein; Provisional; Region: PHA03160 272631000132 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 272631000133 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272631000134 P-loop; other site 272631000135 Magnesium ion binding site [ion binding]; other site 272631000136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272631000137 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 272631000138 PPE family; Region: PPE; pfam00823 272631000139 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 272631000140 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631000141 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631000142 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 272631000143 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631000144 Protein of unknown function (DUF690); Region: DUF690; pfam05108 272631000145 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 272631000146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631000147 Walker A motif; other site 272631000148 ATP binding site [chemical binding]; other site 272631000149 Walker B motif; other site 272631000150 arginine finger; other site 272631000151 EspG family; Region: ESX-1_EspG; pfam14011 272631000152 conserved hypothetical protein (pseudogene) 272631000153 conserved hypothetical protein (pseudogene) 272631000154 hypothetical protein (pseudogene) 272631000155 conserved hypothetical protein (pseudogene) 272631000156 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272631000157 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272631000158 active site 272631000159 dimer interface [polypeptide binding]; other site 272631000160 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272631000161 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272631000162 active site 272631000163 FMN binding site [chemical binding]; other site 272631000164 substrate binding site [chemical binding]; other site 272631000165 3Fe-4S cluster binding site [ion binding]; other site 272631000166 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272631000167 domain interface; other site 272631000168 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 272631000169 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 272631000170 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272631000171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272631000172 NAD(P) binding pocket [chemical binding]; other site 272631000173 conserved hypothetical protein (pseudogene) 272631000174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631000175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631000176 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 272631000177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272631000178 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 272631000179 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 272631000180 sequence-specific DNA binding site [nucleotide binding]; other site 272631000181 salt bridge; other site 272631000182 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272631000183 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272631000184 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272631000185 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 272631000186 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272631000187 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 272631000188 putative active site [active] 272631000189 catalytic site [active] 272631000190 putative metal binding site [ion binding]; other site 272631000191 bacterioferritin (pseudogene) 272631000192 hypothetical protein (pseudogene) 272631000193 hypothetical protein (pseudogene) 272631000194 prephenate dehydratase; Provisional; Region: PRK11898 272631000195 Prephenate dehydratase; Region: PDT; pfam00800 272631000196 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272631000197 putative L-Phe binding site [chemical binding]; other site 272631000198 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272631000199 catalytic core [active] 272631000200 hypothetical protein (pseudogene) 272631000201 Septum formation; Region: Septum_form; pfam13845 272631000202 Septum formation; Region: Septum_form; pfam13845 272631000203 seryl-tRNA synthetase; Provisional; Region: PRK05431 272631000204 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272631000205 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272631000206 motif 1; other site 272631000207 dimer interface [polypeptide binding]; other site 272631000208 active site 272631000209 motif 2; other site 272631000210 motif 3; other site 272631000211 hypothetical protein (pseudogene) 272631000212 hypothetical protein (pseudogene) 272631000213 hypothetical protein (pseudogene) 272631000214 probable aminoglycoside 3'-phosphotransferase (pseudogene) 272631000215 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272631000216 putative acyl-acceptor binding pocket; other site 272631000217 probable acyltransferase (pseudogene) 272631000218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272631000219 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272631000220 active site 272631000221 motif I; other site 272631000222 motif II; other site 272631000223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272631000224 hypothetical protein (pseudogene) 272631000225 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 272631000226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272631000227 UDP-galactopyranose mutase; Region: GLF; pfam03275 272631000228 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272631000229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272631000230 active site 272631000231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272631000232 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272631000233 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 272631000234 active site 272631000235 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 272631000236 putative active site [active] 272631000237 Predicted esterase [General function prediction only]; Region: COG0627 272631000238 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 272631000239 Predicted esterase [General function prediction only]; Region: COG0627 272631000240 Cutinase; Region: Cutinase; pfam01083 272631000241 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 272631000242 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272631000243 acyl-activating enzyme (AAE) consensus motif; other site 272631000244 active site 272631000245 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272631000246 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631000247 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631000248 active site 272631000249 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272631000250 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272631000251 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 272631000252 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272631000253 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272631000254 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272631000255 acyl-CoA dehydrogenase (pseudogene) 272631000256 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 272631000257 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 272631000258 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 272631000259 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 272631000260 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 272631000261 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 272631000262 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 272631000263 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 272631000264 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272631000265 classical (c) SDRs; Region: SDR_c; cd05233 272631000266 NAD(P) binding site [chemical binding]; other site 272631000267 active site 272631000268 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272631000269 FAD binding domain; Region: FAD_binding_4; pfam01565 272631000270 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 272631000271 Predicted membrane protein [Function unknown]; Region: COG2246 272631000272 conserved hypothetical protein (pseudogene) 272631000273 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272631000274 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272631000275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272631000276 active site 272631000277 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272631000278 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272631000279 Walker A/P-loop; other site 272631000280 ATP binding site [chemical binding]; other site 272631000281 Q-loop/lid; other site 272631000282 ABC transporter signature motif; other site 272631000283 Walker B; other site 272631000284 D-loop; other site 272631000285 H-loop/switch region; other site 272631000286 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 272631000287 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 272631000288 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272631000289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272631000290 catalytic residue [active] 272631000291 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 272631000292 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 272631000293 NAD(P) binding site [chemical binding]; other site 272631000294 Beta-lactamase; Region: Beta-lactamase; pfam00144 272631000295 enoyl-CoA hydratase; Provisional; Region: PRK06142 272631000296 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631000297 substrate binding site [chemical binding]; other site 272631000298 oxyanion hole (OAH) forming residues; other site 272631000299 trimer interface [polypeptide binding]; other site 272631000300 GXWXG protein; Region: GXWXG; pfam14231 272631000301 histidinol-phosphate aminotransferase (pseudogene) 272631000302 conserved hypothetical protein (pseudogene) 272631000303 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272631000304 hydrophobic ligand binding site; other site 272631000305 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 272631000306 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 272631000307 homodimer interface [polypeptide binding]; other site 272631000308 active site 272631000309 TDP-binding site; other site 272631000310 acceptor substrate-binding pocket; other site 272631000311 Methyltransferase domain; Region: Methyltransf_24; pfam13578 272631000312 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 272631000313 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 272631000314 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 272631000315 homodimer interface [polypeptide binding]; other site 272631000316 active site 272631000317 TDP-binding site; other site 272631000318 Uncharacterized conserved protein [Function unknown]; Region: COG3268 272631000319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631000320 S-adenosylmethionine binding site [chemical binding]; other site 272631000321 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 272631000322 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 272631000323 acyl-CoA synthetase; Validated; Region: PRK05850 272631000324 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272631000325 acyl-activating enzyme (AAE) consensus motif; other site 272631000326 active site 272631000327 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 272631000328 acyl-CoA synthetase; Validated; Region: PRK06060 272631000329 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631000330 acyl-activating enzyme (AAE) consensus motif; other site 272631000331 AMP binding site [chemical binding]; other site 272631000332 active site 272631000333 CoA binding site [chemical binding]; other site 272631000334 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272631000335 Erythronolide synthase docking; Region: Docking; pfam08990 272631000336 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631000337 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631000338 active site 272631000339 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272631000340 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 272631000341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631000342 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 272631000343 Enoylreductase; Region: PKS_ER; smart00829 272631000344 NAD(P) binding site [chemical binding]; other site 272631000345 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 272631000346 short chain dehydrogenase; Region: adh_short; pfam00106 272631000347 putative NADP binding site [chemical binding]; other site 272631000348 active site 272631000349 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272631000350 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 272631000351 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 272631000352 MMPL family; Region: MMPL; cl14618 272631000353 MMPL family; Region: MMPL; cl14618 272631000354 acyl-CoA synthetase; Validated; Region: PRK05850 272631000355 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272631000356 acyl-activating enzyme (AAE) consensus motif; other site 272631000357 active site 272631000358 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631000359 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631000360 active site 272631000361 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 272631000362 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 272631000363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631000364 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 272631000365 Enoylreductase; Region: PKS_ER; smart00829 272631000366 NAD(P) binding site [chemical binding]; other site 272631000367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631000368 NAD(P) binding site [chemical binding]; other site 272631000369 short chain dehydrogenase; Region: adh_short; pfam00106 272631000370 active site 272631000371 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272631000372 conserved hypothetical protein (pseudogene) 272631000373 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 272631000375 group II intron maturase-related protein 272631000377 hypothetical protein (pseudogene) 272631000379 possible formamidopyrimidine-DNA glycosylase (pseudogene) 272631000380 ketoacyl reductase (pseudogene) 272631000381 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 272631000382 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272631000383 active site 272631000384 dimer interface [polypeptide binding]; other site 272631000385 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272631000386 dimer interface [polypeptide binding]; other site 272631000387 active site 272631000388 hypothetical protein; Provisional; Region: PRK07857 272631000389 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272631000390 Part of AAA domain; Region: AAA_19; pfam13245 272631000391 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272631000392 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272631000393 Peptidase family M23; Region: Peptidase_M23; pfam01551 272631000394 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 272631000395 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272631000396 CoA-ligase; Region: Ligase_CoA; pfam00549 272631000397 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272631000398 CoA binding domain; Region: CoA_binding; smart00881 272631000399 CoA-ligase; Region: Ligase_CoA; pfam00549 272631000400 similar to alkanal monooxygenase beta chains (pseudogene) 272631000401 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272631000402 active site 272631000403 substrate binding site [chemical binding]; other site 272631000404 cosubstrate binding site; other site 272631000405 catalytic site [active] 272631000406 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272631000407 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272631000408 purine monophosphate binding site [chemical binding]; other site 272631000409 dimer interface [polypeptide binding]; other site 272631000410 putative catalytic residues [active] 272631000411 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272631000412 hypothetical protein (pseudogene) 272631000413 acyl-CoA dehydrogenase (pseudogene) 272631000414 acetyl/propionyl-CoA carboxylase, [beta] subunit (pseudogene) 272631000415 acetyl/propionyl-CoA carboxylase, [alpha] subunit (pseudogene) 272631000416 acyl-CoA dehydrogenase (pseudogene) 272631000417 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631000418 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 272631000419 conserved hypothetical protein (pseudogene) 272631000420 conserved hypothetical protein (pseudogene) 272631000421 hypothetical protein (pseudogene) 272631000422 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 272631000423 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272631000424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272631000425 active site 272631000426 phosphorylation site [posttranslational modification] 272631000427 intermolecular recognition site; other site 272631000428 dimerization interface [polypeptide binding]; other site 272631000429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272631000430 DNA binding site [nucleotide binding] 272631000431 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272631000432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272631000433 dimerization interface [polypeptide binding]; other site 272631000434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272631000435 dimer interface [polypeptide binding]; other site 272631000436 phosphorylation site [posttranslational modification] 272631000437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272631000438 ATP binding site [chemical binding]; other site 272631000439 Mg2+ binding site [ion binding]; other site 272631000440 G-X-G motif; other site 272631000441 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272631000442 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 272631000443 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272631000444 MPT binding site; other site 272631000445 trimer interface [polypeptide binding]; other site 272631000446 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272631000447 hypothetical protein (pseudogene) 272631000448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 272631000449 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272631000450 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 272631000451 active site 272631000452 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272631000453 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272631000454 dimer interface [polypeptide binding]; other site 272631000455 putative functional site; other site 272631000456 putative MPT binding site; other site 272631000457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272631000458 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272631000459 hypothetical protein (pseudogene) 272631000460 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272631000461 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272631000462 ligand binding site [chemical binding]; other site 272631000463 flexible hinge region; other site 272631000464 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272631000465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272631000466 Coenzyme A binding pocket [chemical binding]; other site 272631000467 hypothetical protein (pseudogene) 272631000468 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 272631000469 arginine deiminase (pseudogene) 272631000470 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 272631000471 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 272631000472 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272631000473 putative SAM binding site [chemical binding]; other site 272631000474 putative homodimer interface [polypeptide binding]; other site 272631000475 PE_PGRS-family protein (pseudogene) 272631000476 hypothetical protein (pseudogene) 272631000477 PE-family protein (pseudogene) 272631000478 ATP-dependent DNA/RNA helicase (pseudogene) 272631000479 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272631000480 DNA-binding site [nucleotide binding]; DNA binding site 272631000481 RNA-binding motif; other site 272631000482 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 272631000483 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272631000484 active site 272631000485 interdomain interaction site; other site 272631000486 putative metal-binding site [ion binding]; other site 272631000487 nucleotide binding site [chemical binding]; other site 272631000488 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272631000489 domain I; other site 272631000490 DNA binding groove [nucleotide binding] 272631000491 phosphate binding site [ion binding]; other site 272631000492 domain II; other site 272631000493 domain III; other site 272631000494 nucleotide binding site [chemical binding]; other site 272631000495 catalytic site [active] 272631000496 domain IV; other site 272631000497 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272631000498 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272631000499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272631000500 dimerization interface [polypeptide binding]; other site 272631000501 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272631000502 cyclase homology domain; Region: CHD; cd07302 272631000503 nucleotidyl binding site; other site 272631000504 metal binding site [ion binding]; metal-binding site 272631000505 dimer interface [polypeptide binding]; other site 272631000506 DNA polymerase III subunit delta'; Validated; Region: PRK07940 272631000507 AAA ATPase domain; Region: AAA_16; pfam13191 272631000508 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272631000509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272631000510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631000511 NAD(P) binding site [chemical binding]; other site 272631000512 active site 272631000513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 272631000514 unknown membrane protein (pseudogene) 272631000515 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272631000516 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272631000517 Ligand binding site; other site 272631000518 Putative Catalytic site; other site 272631000519 DXD motif; other site 272631000520 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 272631000521 hypothetical protein (pseudogene) 272631000522 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272631000523 dimer interface [polypeptide binding]; other site 272631000524 substrate binding site [chemical binding]; other site 272631000525 metal binding sites [ion binding]; metal-binding site 272631000526 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 272631000527 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 272631000528 hypothetical protein (pseudogene) 272631000529 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272631000530 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272631000531 Ligand Binding Site [chemical binding]; other site 272631000532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272631000533 active site 272631000534 lipoprotein (pseudogene) 272631000535 conserved hypothetical protein (pseudogene) 272631000536 alcohol dehydrogenase, zinc-type (pseudogene) 272631000537 similar bacterial luciferase alpha chains (pseudogene) 272631000538 hydrolase (pseudogene) 272631000539 FtsH Extracellular; Region: FtsH_ext; pfam06480 272631000540 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272631000541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631000542 Walker A motif; other site 272631000543 ATP binding site [chemical binding]; other site 272631000544 Walker B motif; other site 272631000545 arginine finger; other site 272631000546 Peptidase family M41; Region: Peptidase_M41; pfam01434 272631000547 YppG-like protein; Region: YppG; pfam14179 272631000548 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 272631000549 active site 272631000550 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272631000551 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272631000552 substrate binding pocket [chemical binding]; other site 272631000553 dimer interface [polypeptide binding]; other site 272631000554 inhibitor binding site; inhibition site 272631000555 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272631000556 homooctamer interface [polypeptide binding]; other site 272631000557 active site 272631000558 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272631000559 catalytic center binding site [active] 272631000560 ATP binding site [chemical binding]; other site 272631000561 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 272631000562 Uncharacterized conserved protein [Function unknown]; Region: COG5495 272631000563 Rossmann-like domain; Region: Rossmann-like; pfam10727 272631000564 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 272631000565 Panthothenate synthetase [Coenzyme metabolism]; Region: PanC; COG0414 272631000566 active site 272631000567 nucleotide binding site [chemical binding]; other site 272631000568 HIGH motif; other site 272631000569 KMSKS motif; other site 272631000570 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 272631000571 tetramerization interface [polypeptide binding]; other site 272631000572 active site 272631000573 pantothenate kinase; Reviewed; Region: PRK13318 272631000574 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272631000575 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272631000576 dimer interface [polypeptide binding]; other site 272631000577 putative anticodon binding site; other site 272631000578 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272631000579 motif 1; other site 272631000580 dimer interface [polypeptide binding]; other site 272631000581 active site 272631000582 motif 2; other site 272631000583 motif 3; other site 272631000584 Lsr2; Region: Lsr2; pfam11774 272631000585 Clp protease ATP binding subunit; Region: clpC; CHL00095 272631000586 Clp amino terminal domain; Region: Clp_N; pfam02861 272631000587 Clp amino terminal domain; Region: Clp_N; pfam02861 272631000588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631000589 Walker A motif; other site 272631000590 ATP binding site [chemical binding]; other site 272631000591 Walker B motif; other site 272631000592 arginine finger; other site 272631000593 UvrB/uvrC motif; Region: UVR; pfam02151 272631000594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631000595 Walker A motif; other site 272631000596 ATP binding site [chemical binding]; other site 272631000597 Walker B motif; other site 272631000598 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272631000599 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 272631000600 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272631000601 hypothetical protein (pseudogene) 272631000602 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 272631000603 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272631000604 active site 272631000605 HIGH motif; other site 272631000606 KMSKS motif; other site 272631000607 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272631000608 tRNA binding surface [nucleotide binding]; other site 272631000609 anticodon binding site; other site 272631000610 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272631000611 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272631000612 active site 272631000613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 272631000614 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272631000615 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272631000616 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272631000617 G5 domain; Region: G5; pfam07501 272631000618 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 272631000619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631000620 S-adenosylmethionine binding site [chemical binding]; other site 272631000621 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 272631000622 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272631000623 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272631000624 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 272631000625 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272631000626 acyl-activating enzyme (AAE) consensus motif; other site 272631000627 active site 272631000628 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272631000629 putative active site [active] 272631000630 catalytic residue [active] 272631000631 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272631000632 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 272631000633 5S rRNA interface [nucleotide binding]; other site 272631000634 CTC domain interface [polypeptide binding]; other site 272631000635 L16 interface [polypeptide binding]; other site 272631000636 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 272631000637 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 272631000638 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 272631000639 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272631000640 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 272631000641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272631000642 active site 272631000643 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 272631000644 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272631000645 Substrate binding site; other site 272631000646 Mg++ binding site; other site 272631000647 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272631000648 active site 272631000649 substrate binding site [chemical binding]; other site 272631000650 CoA binding site [chemical binding]; other site 272631000651 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631000652 diaminopimelate decarboxylase (pseudogene) 272631000653 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272631000654 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272631000655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272631000656 ATP binding site [chemical binding]; other site 272631000657 putative Mg++ binding site [ion binding]; other site 272631000658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272631000659 nucleotide binding region [chemical binding]; other site 272631000660 ATP-binding site [chemical binding]; other site 272631000661 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 272631000662 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272631000663 conserved hypothetical protein (pseudogene) 272631000664 lipoprotein (pseudogene) 272631000665 enolase; Provisional; Region: eno; PRK00077 272631000666 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272631000667 dimer interface [polypeptide binding]; other site 272631000668 metal binding site [ion binding]; metal-binding site 272631000669 substrate binding pocket [chemical binding]; other site 272631000670 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272631000671 Uncharacterized conserved protein [Function unknown]; Region: COG1507 272631000672 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 272631000673 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 272631000674 conserved large membrane protein (pseudogene) 272631000675 sensor histidine kinase (pseudogene) 272631000676 two-component response regulator (pseudogene) 272631000677 conserved hypothetical protein (pseudogene) 272631000678 PE-family protein (pseudogene) 272631000679 hypothetical protein (pseudogene) 272631000680 conserved hypothetical protein (pseudogene) 272631000681 acetate kinase (pseudogene) 272631000682 phosphate acetyltransferase (pseudogene) 272631000683 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 272631000684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272631000685 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 272631000686 oxidoreductase (pseudogene) 272631000687 acyl-CoA dehydrogenase (pseudogene) 272631000688 hypothetical protein (pseudogene) 272631000689 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272631000690 homodimer interface [polypeptide binding]; other site 272631000691 substrate-cofactor binding pocket; other site 272631000692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631000693 catalytic residue [active] 272631000694 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 272631000695 active site residue [active] 272631000696 PPE-family protein (pseudogene) 272631000697 conserved hypothetical protein (pseudogene) 272631000698 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272631000699 CoenzymeA binding site [chemical binding]; other site 272631000700 subunit interaction site [polypeptide binding]; other site 272631000701 PHB binding site; other site 272631000702 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272631000703 GDP-binding site [chemical binding]; other site 272631000704 ACT binding site; other site 272631000705 IMP binding site; other site 272631000706 conserved hypothetical protein (pseudogene) 272631000707 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272631000708 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 272631000709 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272631000710 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 272631000711 active site 272631000712 intersubunit interface [polypeptide binding]; other site 272631000713 zinc binding site [ion binding]; other site 272631000714 Na+ binding site [ion binding]; other site 272631000715 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272631000717 group II intron maturase-related protein 272631000719 MarR family; Region: MarR_2; cl17246 272631000720 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 272631000721 ThiC-associated domain; Region: ThiC-associated; pfam13667 272631000722 ThiC family; Region: ThiC; pfam01964 272631000723 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272631000724 dimer interface [polypeptide binding]; other site 272631000725 substrate binding site [chemical binding]; other site 272631000726 ATP binding site [chemical binding]; other site 272631000727 hypothetical protein (pseudogene) 272631000728 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 272631000729 ThiS interaction site; other site 272631000730 putative active site [active] 272631000731 tetramer interface [polypeptide binding]; other site 272631000732 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 272631000733 thiS-thiF/thiG interaction site; other site 272631000734 FAD dependent oxidoreductase; Region: DAO; pfam01266 272631000735 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 272631000736 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272631000737 thiamine phosphate binding site [chemical binding]; other site 272631000738 active site 272631000739 pyrophosphate binding site [ion binding]; other site 272631000740 MutT homologue (pseudogene) 272631000741 membrane protein (pseudogene) 272631000742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272631000743 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272631000744 substrate binding pocket [chemical binding]; other site 272631000745 membrane-bound complex binding site; other site 272631000746 hinge residues; other site 272631000747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272631000748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272631000749 active site 272631000750 ATP binding site [chemical binding]; other site 272631000751 substrate binding site [chemical binding]; other site 272631000752 activation loop (A-loop); other site 272631000753 unknown, possible membrane protein, (pseudogene) 272631000754 possible transmembrane protein (pseudogene) 272631000755 conserved hypothetical protein (pseudogene) 272631000756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272631000757 ATPase of AAA-family (pseudogene) 272631000758 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272631000759 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272631000760 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 272631000761 molybdenum cofactor biosynthesis, protein A (pseudogene) 272631000762 probable oxidoreductase (pseudogene) 272631000763 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 272631000764 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272631000765 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272631000766 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 272631000767 putative NAD(P) binding site [chemical binding]; other site 272631000768 active site 272631000769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631000770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631000771 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272631000772 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272631000773 ring oligomerisation interface [polypeptide binding]; other site 272631000774 ATP/Mg binding site [chemical binding]; other site 272631000775 stacking interactions; other site 272631000776 hinge regions; other site 272631000777 probable DNA repair RadA homologue (pseudogene) 272631000778 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 272631000779 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272631000780 substrate binding site; other site 272631000781 dimer interface; other site 272631000782 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272631000783 homotrimer interaction site [polypeptide binding]; other site 272631000784 zinc binding site [ion binding]; other site 272631000785 CDP-binding sites; other site 272631000786 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272631000787 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272631000788 active site 272631000789 HIGH motif; other site 272631000790 KMSKS motif; other site 272631000791 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272631000792 tRNA binding surface [nucleotide binding]; other site 272631000793 anticodon binding site; other site 272631000794 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272631000795 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272631000796 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272631000797 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272631000798 conserved hypothetical protein (pseudogene) 272631000799 conserved hypothetical protein (pseudogene) 272631000800 PPE-family protein (pseudogene) 272631000801 conserved hypothetical protein (pseudogene) 272631000802 conserved hypothetical protein (pseudogene) 272631000803 probable arsenical pump (pseudogene) 272631000804 hypothetical protein (pseudogene) 272631000805 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 272631000806 putative active site [active] 272631000807 similar to ser-thr-protein kinases (pseudogene) 272631000808 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272631000809 ABC-ATPase subunit interface; other site 272631000810 dimer interface [polypeptide binding]; other site 272631000811 putative PBP binding regions; other site 272631000812 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272631000813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272631000814 Walker A/P-loop; other site 272631000815 ATP binding site [chemical binding]; other site 272631000816 Q-loop/lid; other site 272631000817 ABC transporter signature motif; other site 272631000818 Walker B; other site 272631000819 D-loop; other site 272631000820 H-loop/switch region; other site 272631000821 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272631000822 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 272631000823 metal binding site [ion binding]; metal-binding site 272631000824 transcriptional regulator (LacI family) (pseudogene) 272631000825 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631000826 acyl-CoA dehydrogenase (pseudogene) 272631000827 hypothetical protein (pseudogene) 272631000828 electron transfer component of (pseudogene) 272631000829 oxidoreductase (pseudogene) 272631000830 probable hydrolase (pseudogene) 272631000831 lipid carrier protein (pseudogene) 272631000832 transcriptional regulator (pseudogene) 272631000833 conserved hypothetical protein (pseudogene) 272631000834 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 272631000835 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 272631000836 hypothetical protein (pseudogene) 272631000837 probable transferase (pseudogene) 272631000838 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631000839 acyl-CoA synthase (pseudogene) 272631000840 conserved hypothetical protein (pseudogene) 272631000841 hypothetical protein; Validated; Region: PRK07586 272631000842 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272631000843 PYR/PP interface [polypeptide binding]; other site 272631000844 dimer interface [polypeptide binding]; other site 272631000845 TPP binding site [chemical binding]; other site 272631000846 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 272631000847 TPP-binding site [chemical binding]; other site 272631000848 dimer interface [polypeptide binding]; other site 272631000849 acyl-CoA synthase (pseudogene) 272631000850 acyl-CoA dehydrogenase (pseudogene) 272631000851 acyl-CoA dehydrogenase (pseudogene) 272631000852 ferredoxin (pseudogene) 272631000853 dehydrogenase (pseudogene) 272631000854 part of mce4 operon (pseudogene) 272631000855 part of mce4 operon (pseudogene) 272631000856 cell invasion protein (pseudogene) 272631000857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272631000858 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272631000859 23S rRNA interface [nucleotide binding]; other site 272631000860 L3 interface [polypeptide binding]; other site 272631000861 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272631000862 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 272631000863 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272631000864 active site 272631000865 substrate binding site [chemical binding]; other site 272631000866 metal binding site [ion binding]; metal-binding site 272631000867 hypothetical protein (pseudogene) 272631000868 conserved hypothetical protein (pseudogene) 272631000869 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 272631000870 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272631000871 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272631000872 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272631000873 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272631000874 glutaminase active site [active] 272631000875 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272631000876 dimer interface [polypeptide binding]; other site 272631000877 active site 272631000878 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272631000879 dimer interface [polypeptide binding]; other site 272631000880 active site 272631000881 conserved hypothetical protein (pseudogene) 272631000882 Uncharacterized conserved protein [Function unknown]; Region: COG0062 272631000883 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272631000884 putative substrate binding site [chemical binding]; other site 272631000885 putative ATP binding site [chemical binding]; other site 272631000886 glutamate decarboxylase (pseudogene) 272631000887 alanine racemase; Reviewed; Region: alr; PRK00053 272631000888 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272631000889 active site 272631000890 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272631000891 dimer interface [polypeptide binding]; other site 272631000892 substrate binding site [chemical binding]; other site 272631000893 catalytic residues [active] 272631000894 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272631000895 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 272631000896 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 272631000897 Glycoprotease family; Region: Peptidase_M22; pfam00814 272631000898 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272631000899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272631000900 Coenzyme A binding pocket [chemical binding]; other site 272631000901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272631000902 UGMP family protein; Validated; Region: PRK09604 272631000903 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272631000904 oligomerisation interface [polypeptide binding]; other site 272631000905 mobile loop; other site 272631000906 roof hairpin; other site 272631000907 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272631000908 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272631000909 ring oligomerisation interface [polypeptide binding]; other site 272631000910 ATP/Mg binding site [chemical binding]; other site 272631000911 stacking interactions; other site 272631000912 hinge regions; other site 272631000913 Transcription factor WhiB; Region: Whib; pfam02467 272631000914 ECF subfamily sigma subunit (pseudogene) 272631000915 hypothetical protein (pseudogene) 272631000916 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272631000917 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272631000918 active site 272631000919 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272631000920 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 272631000921 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272631000922 phosphate binding site [ion binding]; other site 272631000923 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 272631000924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272631000925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631000926 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272631000927 possibe dioxygenase (pseudogene) 272631000928 transcriptional regulator (pseudogene) 272631000929 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 272631000930 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272631000931 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272631000932 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272631000933 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 272631000934 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272631000935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272631000936 motif II; other site 272631000937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631000938 S-adenosylmethionine binding site [chemical binding]; other site 272631000939 GMP synthase; Reviewed; Region: guaA; PRK00074 272631000940 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272631000941 AMP/PPi binding site [chemical binding]; other site 272631000942 candidate oxyanion hole; other site 272631000943 catalytic triad [active] 272631000944 potential glutamine specificity residues [chemical binding]; other site 272631000945 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272631000946 ATP Binding subdomain [chemical binding]; other site 272631000947 Ligand Binding sites [chemical binding]; other site 272631000948 Dimerization subdomain; other site 272631000949 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 272631000950 PAS domain S-box; Region: sensory_box; TIGR00229 272631000951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272631000952 putative active site [active] 272631000953 heme pocket [chemical binding]; other site 272631000954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272631000955 metal binding site [ion binding]; metal-binding site 272631000956 active site 272631000957 I-site; other site 272631000958 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272631000959 TM-ABC transporter signature motif; other site 272631000960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272631000961 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 272631000962 putative ligand binding site [chemical binding]; other site 272631000963 hypothetical protein (pseudogene) 272631000964 hypothetical protein (pseudogene) 272631000965 phosphate transport system regulator (pseudogene) 272631000966 cutinase (pseudogene) 272631000967 probable inosine-uridine preferring nucleoside (pseudogene) 272631000968 cyclopropanemycolic acid synthase (pseudogene) 272631000969 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 272631000970 FeS assembly ATPase SufC; Region: sufC; TIGR01978 272631000971 possible IS1081 transposase (pseudogene) 272631000972 possible IS6110 transposase (pseudogene) 272631000973 PE family; Region: PE; pfam00934 272631000974 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 272631000975 PPE family; Region: PPE; pfam00823 272631000976 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 272631000977 lipoprotein (pseudogene) 272631000978 dehydrogenase (pseudogene) 272631000979 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272631000980 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 272631000981 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 272631000982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272631000983 active site 272631000984 motif I; other site 272631000985 motif II; other site 272631000986 conserved hypothetical protein (pseudogene) 272631000987 DNA polymerase III [alpha] chain (pseudogene) 272631000988 conserved hypothetical protein (pseudogene) 272631000989 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 272631000990 FMN binding site [chemical binding]; other site 272631000991 dimer interface [polypeptide binding]; other site 272631000992 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272631000993 conserved hypothetical protein (pseudogene) 272631000994 hypothetical protein (pseudogene) 272631000995 hypothetical protein (pseudogene) 272631000996 hypothetical protein (pseudogene) 272631000997 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272631000998 catalytic triad [active] 272631000999 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 272631001000 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 272631001001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272631001002 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 272631001003 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272631001004 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 272631001005 catalytic site [active] 272631001006 putative active site [active] 272631001007 putative substrate binding site [chemical binding]; other site 272631001008 dimer interface [polypeptide binding]; other site 272631001009 conserved hypothetical protein (pseudogene) 272631001010 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272631001011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631001012 NAD(P) binding site [chemical binding]; other site 272631001013 active site 272631001014 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 272631001015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272631001016 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631001017 acyl-CoA synthase (pseudogene) 272631001018 3-oxo acid:CoA transferase, [alpha] subunit (pseudogene) 272631001019 3-oxo acid:CoA transferase, [beta] subunit (pseudogene) 272631001020 acetyl/propionyl-CoA carboxylase, [beta] subunit (pseudogene) 272631001021 acetyl/propionyl-CoA carboxylase, [alpha] subunit (pseudogene) 272631001022 acyl-CoA dehydrogenase (aka mmgC) (pseudogene) 272631001023 aldehyde dehydrogenase (pseudogene) 272631001024 citrate lyase [beta] chain (pseudogene) 272631001025 pyruvate dehydrogenase E1 component [alpha] subunit (pseudogene) 272631001026 pyruvate dehydrogenase E1 component [beta] subunit (pseudogene) 272631001027 dihydrolipoamide acetyltransferase (pseudogene) 272631001028 group II intron maturase (pseudogene) 272631001029 REP-family protein (pseudogene) 272631001030 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631001031 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272631001032 thioesterase II (pseudogene) 272631001033 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 272631001034 active site 272631001035 multimer interface [polypeptide binding]; other site 272631001036 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272631001037 nudix motif; other site 272631001038 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272631001039 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272631001040 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 272631001041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272631001042 putative acyl-acceptor binding pocket; other site 272631001043 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 272631001044 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 272631001045 nucleotide binding site/active site [active] 272631001046 HIT family signature motif; other site 272631001047 catalytic residue [active] 272631001048 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 272631001049 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 272631001050 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 272631001051 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272631001052 active site 272631001053 dimer interface [polypeptide binding]; other site 272631001054 motif 1; other site 272631001055 motif 2; other site 272631001056 motif 3; other site 272631001057 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272631001058 anticodon binding site; other site 272631001059 hypothetical protein (pseudogene) 272631001060 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272631001061 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 272631001062 active site 272631001063 catalytic tetrad [active] 272631001064 hypothetical protein (pseudogene) 272631001065 hypothetical protein (pseudogene) 272631001066 conserved hypothetical protein (pseudogene) 272631001067 conserved hypothetical protein (pseudogene) 272631001068 hypothetical protein (pseudogene) 272631001069 hypothetical protein (pseudogene) 272631001070 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 272631001071 active site 272631001072 catalytic triad [active] 272631001073 oxyanion hole [active] 272631001074 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272631001075 Predicted permeases [General function prediction only]; Region: COG0730 272631001076 acyl-CoA synthase (pseudogene) 272631001077 ferrous iron transport protein (pseudogene) 272631001078 pyruvate dehydrogenase; Provisional; Region: PRK06546 272631001079 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 272631001080 predicted active site [active] 272631001081 catalytic triad [active] 272631001082 hypothetical protein; Validated; Region: PRK00110 272631001083 spermidine synthase (pseudogene) 272631001084 hypothetical protein (pseudogene) 272631001085 hypothetical protein (pseudogene) 272631001086 hypothetical protein (pseudogene) 272631001087 hypothetical protein (pseudogene) 272631001088 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272631001089 active site 272631001090 putative DNA-binding cleft [nucleotide binding]; other site 272631001091 dimer interface [polypeptide binding]; other site 272631001092 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272631001093 RuvA N terminal domain; Region: RuvA_N; pfam01330 272631001094 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272631001095 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272631001096 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272631001097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631001098 Walker A motif; other site 272631001099 ATP binding site [chemical binding]; other site 272631001100 Walker B motif; other site 272631001101 arginine finger; other site 272631001102 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272631001103 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 272631001104 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631001105 acyl-activating enzyme (AAE) consensus motif; other site 272631001106 AMP binding site [chemical binding]; other site 272631001107 active site 272631001108 CoA binding site [chemical binding]; other site 272631001109 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272631001110 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 272631001111 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 272631001112 putative NAD(P) binding site [chemical binding]; other site 272631001113 active site 272631001114 putative substrate binding site [chemical binding]; other site 272631001115 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272631001116 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272631001117 inhibitor-cofactor binding pocket; inhibition site 272631001118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631001119 catalytic residue [active] 272631001120 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 272631001121 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 272631001122 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272631001123 MMPL family; Region: MMPL; cl14618 272631001124 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272631001125 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 272631001126 Protein export membrane protein; Region: SecD_SecF; pfam02355 272631001127 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272631001128 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272631001129 adenine phosphoribosyltransferases (pseudogene) 272631001130 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 272631001131 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272631001132 Zn2+ binding site [ion binding]; other site 272631001133 Mg2+ binding site [ion binding]; other site 272631001134 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272631001135 synthetase active site [active] 272631001136 NTP binding site [chemical binding]; other site 272631001137 metal binding site [ion binding]; metal-binding site 272631001138 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272631001139 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272631001140 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272631001141 active site 272631001142 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272631001143 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272631001144 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272631001145 dimer interface [polypeptide binding]; other site 272631001146 motif 1; other site 272631001147 active site 272631001148 motif 2; other site 272631001149 motif 3; other site 272631001150 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272631001151 anticodon binding site; other site 272631001152 PE_PGRS-family protein (pseudogene) 272631001153 hypothetical protein (pseudogene) 272631001154 hypothetical protein (pseudogene) 272631001155 hypothetical protein (pseudogene) 272631001156 conserved hypothetical protein (pseudogene) 272631001157 hypothetical protein (pseudogene) 272631001158 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272631001159 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272631001160 dimer interface [polypeptide binding]; other site 272631001161 anticodon binding site; other site 272631001162 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272631001163 homodimer interface [polypeptide binding]; other site 272631001164 motif 1; other site 272631001165 active site 272631001166 motif 2; other site 272631001167 GAD domain; Region: GAD; pfam02938 272631001168 motif 3; other site 272631001169 conserved hypothetical protein (pseudogene) 272631001170 PPE-family protein (pseudogene) 272631001171 transposase (pseudogene) 272631001172 hypothetical protein (pseudogene) 272631001173 hypothetical protein (pseudogene) 272631001174 conserved hypothetical protein (pseudogene) 272631001175 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272631001176 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272631001177 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272631001178 conserved hypothetical protein (pseudogene) 272631001179 recombination factor protein RarA; Reviewed; Region: PRK13342 272631001180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631001181 Walker A motif; other site 272631001182 ATP binding site [chemical binding]; other site 272631001183 Walker B motif; other site 272631001184 arginine finger; other site 272631001185 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272631001186 conserved hypothetical protein (pseudogene) 272631001187 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272631001188 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272631001189 motif 1; other site 272631001190 active site 272631001191 motif 2; other site 272631001192 motif 3; other site 272631001193 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272631001194 DHHA1 domain; Region: DHHA1; pfam02272 272631001195 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272631001196 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 272631001197 dimerization interface [polypeptide binding]; other site 272631001198 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 272631001199 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272631001200 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272631001201 shikimate binding site; other site 272631001202 NAD(P) binding site [chemical binding]; other site 272631001203 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272631001204 Tetramer interface [polypeptide binding]; other site 272631001205 active site 272631001206 FMN-binding site [chemical binding]; other site 272631001207 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 272631001208 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272631001209 ADP binding site [chemical binding]; other site 272631001210 magnesium binding site [ion binding]; other site 272631001211 putative shikimate binding site; other site 272631001212 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272631001213 active site 272631001214 dimer interface [polypeptide binding]; other site 272631001215 metal binding site [ion binding]; metal-binding site 272631001216 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272631001217 trimer interface [polypeptide binding]; other site 272631001218 active site 272631001219 dimer interface [polypeptide binding]; other site 272631001220 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 272631001221 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272631001222 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272631001223 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272631001224 active site 272631001225 elongation factor P; Validated; Region: PRK00529 272631001226 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272631001227 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272631001228 RNA binding site [nucleotide binding]; other site 272631001229 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272631001230 RNA binding site [nucleotide binding]; other site 272631001231 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 272631001232 putative RNA binding site [nucleotide binding]; other site 272631001233 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 272631001234 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272631001235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272631001236 catalytic residue [active] 272631001237 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272631001238 possible oxidoreductase (pseudogene) 272631001239 probable penicillin binding protein (pseudogene) 272631001240 some similarity to methyltransferases (pseudogene) 272631001241 conserved hypothetical protein (pseudogene) 272631001242 regulatory protein pyrimidine biosynthesis (pseudogene) 272631001243 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272631001244 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272631001245 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272631001246 dihydroorotase; Validated; Region: pyrC; PRK09357 272631001247 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272631001248 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272631001249 active site 272631001250 hypothetical protein (pseudogene) 272631001251 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272631001252 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 272631001253 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272631001254 catalytic site [active] 272631001255 subunit interface [polypeptide binding]; other site 272631001256 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272631001257 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272631001258 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272631001259 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 272631001260 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272631001261 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272631001262 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272631001263 IMP binding site; other site 272631001264 dimer interface [polypeptide binding]; other site 272631001265 interdomain contacts; other site 272631001266 partial ornithine binding site; other site 272631001267 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272631001268 active site 272631001269 dimer interface [polypeptide binding]; other site 272631001270 PE family; Region: PE; pfam00934 272631001271 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 272631001272 PPE family; Region: PPE; pfam00823 272631001273 Guanylate kinase; Region: Guanylate_kin; pfam00625 272631001274 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272631001275 catalytic site [active] 272631001276 G-X2-G-X-G-K; other site 272631001277 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 272631001278 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272631001279 Flavoprotein; Region: Flavoprotein; cl19190 272631001280 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 272631001281 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272631001282 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272631001283 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272631001284 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272631001285 probable lipase (pseudogene) 272631001286 probable lipase (pseudogene) 272631001287 possible membrane protein (pseudogene) 272631001288 primosome assembly protein PriA; Provisional; Region: PRK14873 272631001289 similar to phosphatidylethanolamine N-methyltransferase (pseudogene) 272631001290 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272631001291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272631001292 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272631001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631001294 S-adenosylmethionine binding site [chemical binding]; other site 272631001295 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272631001296 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272631001297 putative active site [active] 272631001298 substrate binding site [chemical binding]; other site 272631001299 putative cosubstrate binding site; other site 272631001300 catalytic site [active] 272631001301 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272631001302 substrate binding site [chemical binding]; other site 272631001303 similar to Fmu protein (pseudogene) 272631001304 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272631001305 substrate binding site [chemical binding]; other site 272631001306 hexamer interface [polypeptide binding]; other site 272631001307 metal binding site [ion binding]; metal-binding site 272631001308 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 272631001309 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272631001310 catalytic motif [active] 272631001311 Zn binding site [ion binding]; other site 272631001312 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 272631001313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272631001314 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272631001315 putative substrate translocation pore; other site 272631001316 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 272631001317 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272631001318 Lumazine binding domain; Region: Lum_binding; pfam00677 272631001319 Lumazine binding domain; Region: Lum_binding; pfam00677 272631001320 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272631001321 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 272631001322 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272631001323 dimerization interface [polypeptide binding]; other site 272631001324 active site 272631001325 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272631001326 homopentamer interface [polypeptide binding]; other site 272631001327 active site 272631001328 Bacterial PH domain; Region: bPH_6; pfam10756 272631001329 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272631001330 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272631001331 GIY-YIG motif/motif A; other site 272631001332 active site 272631001333 catalytic site [active] 272631001334 putative DNA binding site [nucleotide binding]; other site 272631001335 metal binding site [ion binding]; metal-binding site 272631001336 UvrB/uvrC motif; Region: UVR; pfam02151 272631001337 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272631001338 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272631001339 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 272631001340 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 272631001341 phosphate binding site [ion binding]; other site 272631001342 putative substrate binding pocket [chemical binding]; other site 272631001343 dimer interface [polypeptide binding]; other site 272631001344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272631001345 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 272631001346 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 272631001347 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 272631001348 conserved hypothetical protein (pseudogene) 272631001349 possible transporter (pseudogene) 272631001350 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 272631001351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272631001352 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272631001353 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272631001354 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272631001355 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272631001356 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272631001357 substrate binding site [chemical binding]; other site 272631001358 hinge regions; other site 272631001359 ADP binding site [chemical binding]; other site 272631001360 catalytic site [active] 272631001361 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272631001362 substrate binding site [chemical binding]; other site 272631001363 dimer interface [polypeptide binding]; other site 272631001364 catalytic triad [active] 272631001365 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 272631001366 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 272631001367 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 272631001368 putative active site [active] 272631001369 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 272631001370 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 272631001371 glucose-6-phosphate 1-dehydrogenase (pseudogene) 272631001372 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 272631001373 putative active site [active] 272631001374 catalytic residue [active] 272631001375 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272631001376 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272631001377 TPP-binding site [chemical binding]; other site 272631001378 dimer interface [polypeptide binding]; other site 272631001379 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272631001380 PYR/PP interface [polypeptide binding]; other site 272631001381 dimer interface [polypeptide binding]; other site 272631001382 TPP binding site [chemical binding]; other site 272631001383 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272631001384 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 272631001385 putative active site [active] 272631001386 Probable quinone oxidoreductase (pseudogene) 272631001387 conserved hypothetical protein (pseudogene) 272631001388 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 272631001389 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272631001390 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272631001391 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272631001392 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272631001393 Walker A/P-loop; other site 272631001394 ATP binding site [chemical binding]; other site 272631001395 Q-loop/lid; other site 272631001396 ABC transporter signature motif; other site 272631001397 Walker B; other site 272631001398 D-loop; other site 272631001399 H-loop/switch region; other site 272631001400 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 272631001401 Predicted transcriptional regulator [Transcription]; Region: COG2345 272631001402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272631001403 putative DNA binding site [nucleotide binding]; other site 272631001404 dimerization interface [polypeptide binding]; other site 272631001405 putative Zn2+ binding site [ion binding]; other site 272631001406 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272631001407 protein-splicing catalytic site; other site 272631001408 thioester formation/cholesterol transfer; other site 272631001409 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 272631001410 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 272631001411 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 272631001412 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272631001413 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272631001414 FeS assembly protein SufD; Region: sufD; TIGR01981 272631001415 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 272631001416 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272631001417 Walker A/P-loop; other site 272631001418 ATP binding site [chemical binding]; other site 272631001419 Q-loop/lid; other site 272631001420 ABC transporter signature motif; other site 272631001421 Walker B; other site 272631001422 D-loop; other site 272631001423 H-loop/switch region; other site 272631001424 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272631001425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272631001426 catalytic residue [active] 272631001427 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272631001428 trimerization site [polypeptide binding]; other site 272631001429 active site 272631001430 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272631001431 acyl-CoA dehydrogenase (pseudogene) 272631001432 acyl-CoA dehydrogenase (pseudogene) 272631001433 conserved hypothetical protein (pseudogene) 272631001434 conserved hypothetical protein (pseudogene) 272631001435 hypothetical protein; Reviewed; Region: PRK07914 272631001436 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 272631001437 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272631001438 Uncharacterized conserved protein [Function unknown]; Region: COG2308 272631001439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 272631001440 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272631001441 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272631001442 Transglutaminase/protease-like homologues; Region: TGc; smart00460 272631001443 conserved hypothetical protein (pseudogene) 272631001444 conserved hypothetical protein (pseudogene) 272631001445 hypothetical protein (pseudogene) 272631001446 GTP-binding protein LepA; Provisional; Region: PRK05433 272631001447 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272631001448 G1 box; other site 272631001449 putative GEF interaction site [polypeptide binding]; other site 272631001450 GTP/Mg2+ binding site [chemical binding]; other site 272631001451 Switch I region; other site 272631001452 G2 box; other site 272631001453 G3 box; other site 272631001454 Switch II region; other site 272631001455 G4 box; other site 272631001456 G5 box; other site 272631001457 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272631001458 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272631001459 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272631001460 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272631001461 conserved hypothetical protein (pseudogene) 272631001462 possible hydroxylase (pseudogene) 272631001463 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 272631001464 sulphate transport system permease protein (pseudogene) 272631001465 sulphate transport system permease protein (pseudogene) 272631001466 sulphate transport ATP-binding protein (pseudogene) 272631001467 conserved hypothetical protein (pseudogene) 272631001468 ECF family sigma factor (pseudogene) 272631001469 hypothetical protein (pseudogene) 272631001470 conserved hypothetical protein (pseudogene) 272631001471 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272631001472 HrcA protein C terminal domain; Region: HrcA; pfam01628 272631001473 chaperone protein DnaJ; Provisional; Region: PRK14278 272631001474 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272631001475 HSP70 interaction site [polypeptide binding]; other site 272631001476 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272631001477 Zn binding sites [ion binding]; other site 272631001478 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272631001479 dimer interface [polypeptide binding]; other site 272631001480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 272631001481 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272631001482 K homology RNA-binding domain; Region: KH; smart00322 272631001483 PhoH-like protein; Region: PhoH; pfam02562 272631001484 metal-binding heat shock protein; Provisional; Region: PRK00016 272631001485 conserved hypothetical protein (pseudogene) 272631001486 GTPase Era; Reviewed; Region: era; PRK00089 272631001487 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272631001488 G1 box; other site 272631001489 GTP/Mg2+ binding site [chemical binding]; other site 272631001490 Switch I region; other site 272631001491 G2 box; other site 272631001492 Switch II region; other site 272631001493 G3 box; other site 272631001494 G4 box; other site 272631001495 G5 box; other site 272631001496 KH domain; Region: KH_2; pfam07650 272631001497 amidase (pseudogene) 272631001498 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272631001499 Recombination protein O N terminal; Region: RecO_N; pfam11967 272631001500 Recombination protein O C terminal; Region: RecO_C; pfam02565 272631001501 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272631001502 active site 272631001503 dimer interface [polypeptide binding]; other site 272631001504 hypothetical protein (pseudogene) 272631001505 lipoprotein (pseudogene) 272631001507 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272631001508 Part of AAA domain; Region: AAA_19; pfam13245 272631001509 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272631001510 HRDC domain; Region: HRDC; pfam00570 272631001511 Transcription factor WhiB; Region: Whib; pfam02467 272631001512 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272631001513 active site 272631001514 ATP binding site [chemical binding]; other site 272631001515 hypothetical protein (pseudogene) 272631001516 Uncharacterized conserved protein [Function unknown]; Region: COG5282 272631001517 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 272631001518 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 272631001519 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272631001520 hypothetical protein; Validated; Region: PRK00068 272631001521 hypothetical protein (pseudogene) 272631001522 probable non-heme haloperoxidase (pseudogene) 272631001523 Probable flavin-containing monoamine oxidase (pseudogene) 272631001524 conserved hypothetical protein (pseudogene) 272631001525 conserved hypothetical protein (pseudogene) 272631001526 transcriptional regulator (pseudogene) 272631001527 REP-family protein (pseudogene) 272631001528 conserved hypothetical protein (pseudogene) 272631001529 hypothetical protein (pseudogene) 272631001530 transcriptional regulator, MoxR homologue (pseudogene) 272631001531 possible membrane protein (pseudogene) 272631001532 NADH dehydrogenase chain N (pseudogene) 272631001533 3-hydroxyacyl-CoA dehydrogenase (pseudogene) 272631001534 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272631001535 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272631001536 active site 272631001537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272631001538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272631001539 active site 272631001540 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 272631001541 active site 272631001542 Some similarity to D-lactate dehydrogenase (pseudogene) 272631001543 ferredoxin-NADP+ reductase; Region: PLN02852 272631001544 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272631001545 Alpha C protein N terminal; Region: AlphaC_N; pfam08829 272631001546 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272631001547 RF-1 domain; Region: RF-1; pfam00472 272631001548 conserved hypothetical protein (pseudogene) 272631001549 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272631001550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272631001551 Walker A/P-loop; other site 272631001552 ATP binding site [chemical binding]; other site 272631001553 Q-loop/lid; other site 272631001554 ABC transporter signature motif; other site 272631001555 Walker B; other site 272631001556 D-loop; other site 272631001557 H-loop/switch region; other site 272631001558 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272631001559 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272631001560 FtsX-like permease family; Region: FtsX; pfam02687 272631001561 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272631001562 SmpB-tmRNA interface; other site 272631001563 hypothetical protein (pseudogene) 272631001564 probable oxidoreductase (pseudogene) 272631001565 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 272631001566 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272631001567 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272631001568 homodimer interface [polypeptide binding]; other site 272631001569 NADP binding site [chemical binding]; other site 272631001570 substrate binding site [chemical binding]; other site 272631001571 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 272631001572 Protein of unknown function (DUF732); Region: DUF732; pfam05305 272631001573 probable oxidoreductase (pseudogene) 272631001574 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272631001575 REP-family protein (pseudogene) 272631001576 conserved hypothetical protein (pseudogene) 272631001577 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 272631001578 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 272631001579 cystathionine [beta]-lyase (pseudogene) 272631001580 isocitrate dehydrogenase (pseudogene) 272631001581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272631001582 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272631001583 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272631001584 active site 272631001585 HIGH motif; other site 272631001586 dimer interface [polypeptide binding]; other site 272631001587 KMSKS motif; other site 272631001588 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 272631001589 N-acetylglucosamine-6-P-deacetylase (pseudogene) 272631001590 glucosamine-fructose-6-phosphateaminotransferase( pseudogene) 272631001591 probable sugar transport protein (pseudogene) 272631001592 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272631001593 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272631001594 probable aminotransferase (pseudogene) 272631001595 similar to SigI, ECF family (pseudogene) 272631001596 hypothetical protein (pseudogene) 272631001597 hypothetical protein (pseudogene) 272631001598 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 272631001599 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272631001600 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272631001601 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 272631001602 L-aspartate oxidase; Provisional; Region: PRK06175 272631001603 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272631001604 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 272631001605 putative Iron-sulfur protein interface [polypeptide binding]; other site 272631001606 putative proximal heme binding site [chemical binding]; other site 272631001607 putative SdhC-like subunit interface [polypeptide binding]; other site 272631001608 putative distal heme binding site [chemical binding]; other site 272631001609 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 272631001610 putative Iron-sulfur protein interface [polypeptide binding]; other site 272631001611 putative proximal heme binding site [chemical binding]; other site 272631001612 putative SdhD-like interface [polypeptide binding]; other site 272631001613 putative distal heme binding site [chemical binding]; other site 272631001614 adenosine deaminase; Provisional; Region: PRK09358 272631001615 active site 272631001616 possible membrane protein (pseudogene) 272631001617 possible membrane protein (pseudogene) 272631001618 probable acid phosphatase (pseudogene) 272631001619 uracil phophoribosyltransferase (pseudogene) 272631001620 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 272631001621 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272631001622 active site 272631001623 substrate binding site [chemical binding]; other site 272631001624 metal binding site [ion binding]; metal-binding site 272631001625 purine nucleoside phosphorylase; Provisional; Region: PRK08202 272631001626 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 272631001627 probable aminohydrolase (pseudogene) 272631001628 probable aminohydrolase (pseudogene) 272631001629 conserved hypothetical protein (pseudogene) 272631001630 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272631001631 putative active site pocket [active] 272631001632 dimerization interface [polypeptide binding]; other site 272631001633 putative catalytic residue [active] 272631001634 dihydrolipoamide dehydrogenase (pseudogene) 272631001635 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 272631001636 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631001637 probable deaminase, riboflavin synthesis (pseudogene) 272631001638 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 272631001639 ATP-dependent helicase (pseudogene) 272631001640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631001641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631001642 aldehyde dehydrogenase (pseudogene) 272631001643 conserved hypothetical protein (pseudogene) 272631001644 transcriptional regulator (Lrp/AsnC family) (pseudogene) 272631001645 lysine-[epsilon] aminotransferase (pseudogene) 272631001646 hypothetical protein (pseudogene) 272631001647 conserved hypothetical protein (pseudogene) 272631001648 anti-sigma B factor (pseudogene) 272631001649 ECF subfamily sigma subunit (pseudogene) 272631001650 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 272631001651 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272631001652 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272631001653 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272631001654 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272631001655 carboxyltransferase (CT) interaction site; other site 272631001656 biotinylation site [posttranslational modification]; other site 272631001657 conserved hypothetical protein (pseudogene) 272631001658 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272631001659 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272631001660 active site residue [active] 272631001661 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272631001662 active site residue [active] 272631001663 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272631001664 active site 272631001665 dimer interface [polypeptide binding]; other site 272631001666 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 272631001667 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272631001668 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272631001669 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272631001670 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272631001671 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 272631001672 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272631001673 Bacterial PH domain; Region: bPH_2; pfam03703 272631001674 Predicted membrane protein [Function unknown]; Region: COG2246 272631001675 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 272631001676 ATP-grasp domain; Region: ATP-grasp; pfam02222 272631001677 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272631001678 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272631001679 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 272631001680 FAD binding site [chemical binding]; other site 272631001681 homotetramer interface [polypeptide binding]; other site 272631001682 substrate binding pocket [chemical binding]; other site 272631001683 catalytic base [active] 272631001684 PstA component of phosphate uptake (pseudogene) 272631001685 PstC component of phosphate uptake (pseudogene) 272631001686 PstS component of phosphate uptake (pseudogene) 272631001687 ABC transport component of phosphate uptake (pseudogene) 272631001688 PstS component of phosphate uptake (pseudogene) 272631001689 serine-threonine protein kinase (pseudogene) 272631001690 conserved hypothetical protein (pseudogene) 272631001691 conserved hypothetical protein (pseudogene) 272631001692 hypothetical protein (pseudogene) 272631001693 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272631001694 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272631001695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272631001696 active site 272631001697 motif I; other site 272631001698 motif II; other site 272631001699 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272631001700 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 272631001701 hypothetical protein (pseudogene) 272631001702 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272631001703 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 272631001704 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272631001705 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272631001706 NADP binding site [chemical binding]; other site 272631001707 active site 272631001708 putative substrate binding site [chemical binding]; other site 272631001709 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272631001710 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272631001711 Probable Catalytic site; other site 272631001712 metal-binding site 272631001713 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272631001714 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 272631001715 active site 272631001716 Substrate binding site; other site 272631001717 Mg++ binding site; other site 272631001718 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272631001719 conserved hypothetical protein (pseudogene) 272631001720 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272631001721 nudix motif; other site 272631001722 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272631001723 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272631001724 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 272631001725 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 272631001726 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 272631001727 putative FMN binding site [chemical binding]; other site 272631001728 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 272631001729 dimer interface [polypeptide binding]; other site 272631001730 phosphate binding site [ion binding]; other site 272631001731 Transcription factor WhiB; Region: Whib; pfam02467 272631001732 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 272631001733 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 272631001734 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 272631001735 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 272631001736 active site 272631001737 substrate binding site [chemical binding]; other site 272631001738 metal binding site [ion binding]; metal-binding site 272631001739 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272631001740 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 272631001741 hypothetical protein (pseudogene) 272631001742 probable cationic amino acid transporter (pseudogene) 272631001743 possible alkane-1 monooxygenase (pseudogene) 272631001744 possible rubredoxin (pseudogene) 272631001745 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631001746 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 272631001747 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 272631001748 homotetramer interface [polypeptide binding]; other site 272631001749 ligand binding site [chemical binding]; other site 272631001750 catalytic site [active] 272631001751 NAD binding site [chemical binding]; other site 272631001752 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 272631001753 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272631001754 TMP-binding site; other site 272631001755 ATP-binding site [chemical binding]; other site 272631001756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272631001757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272631001758 active site 272631001759 phosphorylation site [posttranslational modification] 272631001760 intermolecular recognition site; other site 272631001761 dimerization interface [polypeptide binding]; other site 272631001762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272631001763 DNA binding site [nucleotide binding] 272631001764 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272631001765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272631001766 dimerization interface [polypeptide binding]; other site 272631001767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272631001768 dimer interface [polypeptide binding]; other site 272631001769 phosphorylation site [posttranslational modification] 272631001770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272631001771 ATP binding site [chemical binding]; other site 272631001772 Mg2+ binding site [ion binding]; other site 272631001773 G-X-G motif; other site 272631001774 lipoprotein LpqB; Provisional; Region: PRK13616 272631001775 Sporulation and spore germination; Region: Germane; pfam10646 272631001776 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 272631001777 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272631001778 30S subunit binding site; other site 272631001779 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272631001780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272631001781 ATP binding site [chemical binding]; other site 272631001782 putative Mg++ binding site [ion binding]; other site 272631001783 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272631001784 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272631001785 membrane protein (pseudogene) 272631001786 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 272631001787 TrkA-C domain; Region: TrkA_C; pfam02080 272631001788 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272631001789 hypothetical protein (pseudogene) 272631001790 conserved hypothetical protein (pseudogene) 272631001791 conserved hypothetical protein (pseudogene) 272631001792 conserved hypothetical protein (pseudogene) 272631001793 hypothetical protein (pseudogene) 272631001794 oxidoreductase (pseudogene) 272631001795 acyl-[ACP] desaturase (pseudogene) 272631001796 beta-ketoadipyl-CoA thiolase (pseudogene) 272631001797 Predicted GTPases [General function prediction only]; Region: COG1162 272631001798 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272631001799 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272631001800 GTP/Mg2+ binding site [chemical binding]; other site 272631001801 G4 box; other site 272631001802 G5 box; other site 272631001803 G1 box; other site 272631001804 Switch I region; other site 272631001805 G2 box; other site 272631001806 G3 box; other site 272631001807 Switch II region; other site 272631001808 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272631001809 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272631001810 hinge; other site 272631001811 active site 272631001812 Uncharacterized conserved protein [Function unknown]; Region: COG2135 272631001813 REP-family protein (pseudogene) 272631001814 arylsulfatase (pseudogene) 272631001815 PPE-family protein (pseudogene) 272631001816 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 272631001817 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 272631001818 Uncharacterized conserved protein [Function unknown]; Region: EbsC; COG2606 272631001819 putative deacylase active site [active] 272631001820 oxidoreductase (pseudogene) 272631001821 ECF subfamily sigma subunit (pseudogene) 272631001823 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272631001824 carboxyltransferase (CT) interaction site; other site 272631001825 biotinylation site [posttranslational modification]; other site 272631001826 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 272631001827 PAS domain S-box; Region: sensory_box; TIGR00229 272631001828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272631001829 Histidine kinase; Region: HisKA_2; pfam07568 272631001830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272631001831 ATP binding site [chemical binding]; other site 272631001832 Mg2+ binding site [ion binding]; other site 272631001833 G-X-G motif; other site 272631001834 Transcription factor WhiB; Region: Whib; pfam02467 272631001835 conserved hypothetical protein (pseudogene) 272631001836 possible acyltransferase (pseudogene) 272631001837 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 272631001838 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272631001839 hypothetical protein (pseudogene) 272631001840 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272631001841 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272631001842 ATP binding site [chemical binding]; other site 272631001843 Mg++ binding site [ion binding]; other site 272631001844 motif III; other site 272631001845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272631001846 nucleotide binding region [chemical binding]; other site 272631001847 ATP-binding site [chemical binding]; other site 272631001848 hypothetical protein (pseudogene) 272631001849 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 272631001850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631001851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631001852 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 272631001853 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 272631001854 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272631001855 ATP binding site [chemical binding]; other site 272631001856 substrate interface [chemical binding]; other site 272631001857 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272631001858 active site residue [active] 272631001859 TIGR02569 family protein; Region: TIGR02569_actnb 272631001860 methyltransferase (pseudogene) 272631001861 probable lipase (pseudogene) 272631001862 hypothetical protein (pseudogene) 272631001863 probable ATP-dependent DNA helicase (pseudogene) 272631001864 potassium channel (pseudogene) 272631001865 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272631001866 metal binding site 2 [ion binding]; metal-binding site 272631001867 putative DNA binding helix; other site 272631001868 metal binding site 1 [ion binding]; metal-binding site 272631001869 dimer interface [polypeptide binding]; other site 272631001870 structural Zn2+ binding site [ion binding]; other site 272631001871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272631001872 dimerization interface [polypeptide binding]; other site 272631001873 putative DNA binding site [nucleotide binding]; other site 272631001874 putative Zn2+ binding site [ion binding]; other site 272631001875 glycyl-tRNA synthetase; Provisional; Region: PRK04173 272631001876 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 272631001877 dimer interface [polypeptide binding]; other site 272631001878 motif 1; other site 272631001879 active site 272631001880 motif 2; other site 272631001881 motif 3; other site 272631001882 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 272631001883 anticodon binding site; other site 272631001884 transposase (pseudogene) 272631001885 PPE-family protein (pseudogene) 272631001886 phospholipase C precursor (pseudogene) 272631001887 precursor of probable membrane protein (pseudogene) 272631001888 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 272631001889 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272631001890 Zn2+ binding site [ion binding]; other site 272631001891 Mg2+ binding site [ion binding]; other site 272631001892 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272631001893 superoxide dismutase precursor (Cu-Zn) (pseudogene) 272631001894 DNA primase; Validated; Region: dnaG; PRK05667 272631001895 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272631001896 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272631001897 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272631001898 active site 272631001899 metal binding site [ion binding]; metal-binding site 272631001900 interdomain interaction site; other site 272631001901 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272631001902 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 272631001903 probable malate oxidoreductase (pseudogene) 272631001904 hypothetical protein (pseudogene) 272631001905 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 272631001906 active site 272631001907 Zn2+ binding site [ion binding]; other site 272631001908 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 272631001909 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 272631001910 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272631001911 trimer interface [polypeptide binding]; other site 272631001912 active site 272631001913 substrate binding site [chemical binding]; other site 272631001914 CoA binding site [chemical binding]; other site 272631001915 cysteine synthase; Region: PLN02565 272631001916 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272631001917 dimer interface [polypeptide binding]; other site 272631001918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631001919 catalytic residue [active] 272631001920 TQXA domain; Region: TQXA_dom; TIGR03934 272631001921 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272631001922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272631001923 catalytic residue [active] 272631001924 lipoprotein (pseudogene) 272631001925 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 272631001926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272631001927 putative substrate translocation pore; other site 272631001928 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272631001929 ABC transporter (pseudogene) 272631001930 conserved hypothetical protein (pseudogene) 272631001931 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 272631001932 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272631001933 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272631001934 Walker A/P-loop; other site 272631001935 ATP binding site [chemical binding]; other site 272631001936 Q-loop/lid; other site 272631001937 ABC transporter signature motif; other site 272631001938 Walker B; other site 272631001939 D-loop; other site 272631001940 H-loop/switch region; other site 272631001941 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272631001942 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272631001943 Walker A/P-loop; other site 272631001944 ATP binding site [chemical binding]; other site 272631001945 Q-loop/lid; other site 272631001946 ABC transporter signature motif; other site 272631001947 Walker B; other site 272631001948 D-loop; other site 272631001949 H-loop/switch region; other site 272631001950 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272631001951 non-specific lipid transport protein (pseudogene) 272631001952 iron-dependent transcriptional repressor (pseudogene) 272631001953 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272631001954 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272631001955 active site 272631001956 Riboflavin kinase; Region: Flavokinase; smart00904 272631001957 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272631001958 16S/18S rRNA binding site [nucleotide binding]; other site 272631001959 S13e-L30e interaction site [polypeptide binding]; other site 272631001960 25S rRNA binding site [nucleotide binding]; other site 272631001961 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 272631001962 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 272631001963 oligomer interface [polypeptide binding]; other site 272631001964 RNA binding site [nucleotide binding]; other site 272631001965 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272631001966 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272631001967 RNase E interface [polypeptide binding]; other site 272631001968 trimer interface [polypeptide binding]; other site 272631001969 active site 272631001970 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272631001971 putative nucleic acid binding region [nucleotide binding]; other site 272631001972 G-X-X-G motif; other site 272631001973 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272631001974 RNA binding site [nucleotide binding]; other site 272631001975 domain interface; other site 272631001976 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272631001977 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272631001978 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272631001979 probable oxidoreductase (pseudogene) 272631001980 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 272631001981 lipoyl synthase; Provisional; Region: PRK05481 272631001982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272631001983 FeS/SAM binding site; other site 272631001984 lipoate-protein ligase B; Provisional; Region: PRK14345 272631001985 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 272631001986 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 272631001987 putative NAD(P) binding site [chemical binding]; other site 272631001988 putative active site [active] 272631001989 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 272631001990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272631001991 E3 interaction surface; other site 272631001992 lipoyl attachment site [posttranslational modification]; other site 272631001993 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272631001994 E3 interaction surface; other site 272631001995 lipoyl attachment site [posttranslational modification]; other site 272631001996 e3 binding domain; Region: E3_binding; pfam02817 272631001997 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272631001998 short chain dehydrogenase; Validated; Region: PRK05855 272631001999 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272631002000 classical (c) SDRs; Region: SDR_c; cd05233 272631002001 NAD(P) binding site [chemical binding]; other site 272631002002 active site 272631002003 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272631002004 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272631002005 interface (dimer of trimers) [polypeptide binding]; other site 272631002006 Substrate-binding/catalytic site; other site 272631002007 Zn-binding sites [ion binding]; other site 272631002008 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 272631002009 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 272631002010 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272631002011 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272631002012 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272631002013 homodimer interface [polypeptide binding]; other site 272631002014 substrate-cofactor binding pocket; other site 272631002015 catalytic residue [active] 272631002016 cobalamin (5'-phosphate) synthase (pseudogene) 272631002017 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272631002018 putative dimer interface [polypeptide binding]; other site 272631002019 active site pocket [active] 272631002020 putative cataytic base [active] 272631002021 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 272631002022 conserved hypothetical protein (pseudogene) 272631002023 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272631002024 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 272631002025 substrate binding site [chemical binding]; other site 272631002026 ATP binding site [chemical binding]; other site 272631002027 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 272631002028 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272631002029 active site 272631002030 dimer interface [polypeptide binding]; other site 272631002031 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272631002032 Ligand Binding Site [chemical binding]; other site 272631002033 Molecular Tunnel; other site 272631002034 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 272631002035 Cupredoxin superfamily; Region: Cupredoxin; cl19115 272631002036 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 272631002037 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 272631002038 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 272631002039 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 272631002040 heme bH binding site [chemical binding]; other site 272631002041 Qi binding site; other site 272631002042 intrachain domain interface; other site 272631002043 heme bL binding site [chemical binding]; other site 272631002044 interchain domain interface [polypeptide binding]; other site 272631002045 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 272631002046 Qo binding site; other site 272631002047 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 272631002048 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 272631002049 iron-sulfur cluster [ion binding]; other site 272631002050 [2Fe-2S] cluster binding site [ion binding]; other site 272631002051 Cytochrome c; Region: Cytochrom_C; cl11414 272631002052 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272631002053 Cytochrome c; Region: Cytochrom_C; pfam00034 272631002054 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272631002055 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272631002056 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 272631002057 Subunit I/III interface [polypeptide binding]; other site 272631002058 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272631002059 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272631002060 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272631002061 conserved hypothetical protein (pseudogene) 272631002062 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272631002063 NlpC/P60 family; Region: NLPC_P60; pfam00877 272631002064 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272631002065 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272631002066 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 272631002067 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 272631002068 acyl-activating enzyme (AAE) consensus motif; other site 272631002069 putative AMP binding site [chemical binding]; other site 272631002070 putative active site [active] 272631002071 putative CoA binding site [chemical binding]; other site 272631002072 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 272631002073 putative hydrophobic ligand binding site [chemical binding]; other site 272631002074 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 272631002075 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272631002076 P loop; other site 272631002077 Nucleotide binding site [chemical binding]; other site 272631002078 DTAP/Switch II; other site 272631002079 Switch I; other site 272631002080 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272631002081 putative acyl-acceptor binding pocket; other site 272631002082 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 272631002083 probable integral membrane protein (pseudogene) 272631002084 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 272631002085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272631002086 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272631002087 active site 272631002088 ATP binding site [chemical binding]; other site 272631002089 substrate binding site [chemical binding]; other site 272631002090 activation loop (A-loop); other site 272631002091 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 272631002092 geranylgeranyl pyrophosphate synthase (pseudogene) 272631002093 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 272631002094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272631002095 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272631002096 Coenzyme A binding pocket [chemical binding]; other site 272631002097 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 272631002098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 272631002099 MraZ protein; Region: MraZ; pfam02381 272631002100 MraZ protein; Region: MraZ; pfam02381 272631002101 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 272631002102 large tegument protein UL36; Provisional; Region: PHA03247 272631002103 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272631002104 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272631002105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272631002106 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272631002107 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272631002108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272631002109 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272631002110 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272631002111 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272631002112 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272631002113 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272631002114 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272631002115 Mg++ binding site [ion binding]; other site 272631002116 putative catalytic motif [active] 272631002117 putative substrate binding site [chemical binding]; other site 272631002118 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 272631002119 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 272631002120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272631002121 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272631002122 cell division protein FtsW; Region: ftsW; TIGR02614 272631002123 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272631002124 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272631002125 active site 272631002126 homodimer interface [polypeptide binding]; other site 272631002127 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272631002128 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272631002129 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272631002130 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272631002131 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272631002132 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272631002133 Cell division protein FtsQ; Region: FtsQ; pfam03799 272631002134 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272631002135 nucleotide binding site [chemical binding]; other site 272631002136 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 272631002137 SulA interaction site; other site 272631002138 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272631002139 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 272631002140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272631002141 catalytic residue [active] 272631002142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 272631002143 Predicted integral membrane protein [Function unknown]; Region: COG0762 272631002144 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272631002145 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272631002146 Flagellar assembly protein FliH; Region: FliH; cl19405 272631002147 Ca2+ regulator and membrane fusion protein Fig1; Region: Fig1; pfam12351 272631002148 conserved hypothetical protein (pseudogene) 272631002149 glutamine synthetase, type I; Region: GlnA; TIGR00653 272631002150 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272631002151 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272631002152 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 272631002153 probable magnesium transport ATPase protein C (pseudogene) 272631002154 probable dehydrogenase (pseudogene) 272631002155 hypothetical protein (pseudogene) 272631002156 conserved hypothetical protein (pseudogene) 272631002157 hypothetical protein (pseudogene) 272631002158 flavoprotein (pseudogene) 272631002160 group II intron maturase-related protein 272631002162 hypothetical protein (pseudogene) 272631002163 conserved hypothetical protein (pseudogene) 272631002164 hypothetical protein (pseudogene) 272631002165 glucose-6-phosphate 1-dehydrogenase (pseudogene) 272631002166 6-phosphogluconate dehydrogenase (Gram +) (pseudogene) 272631002167 possible non-heme bromoperoxidase (pseudogene) 272631002168 PE family; Region: PE; pfam00934 272631002169 hypothetical protein (pseudogene). 272631002170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631002171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631002172 possible epoxide hydrolase (pseudogene) 272631002173 hypothetical protein (pseudogene) 272631002174 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272631002175 conserved hypothetical protein (pseudogene) 272631002176 pyruvate phosphate dikinase; Provisional; Region: PRK05878 272631002177 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272631002178 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272631002179 Predicted membrane protein [Function unknown]; Region: COG2259 272631002180 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 272631002181 possible membrane transporter (pseudogene) 272631002182 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 272631002183 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 272631002184 THF binding site; other site 272631002185 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272631002186 substrate binding site [chemical binding]; other site 272631002187 THF binding site; other site 272631002188 zinc-binding site [ion binding]; other site 272631002189 possible transposase (pseudogene) 272631002190 possible conserved hypothetical protein (pseudogene) 272631002191 conserved hypothetical protein (pseudogene) 272631002192 polyketide synthase (chalcone synthase-like) (pseudogene) 272631002193 conserved hypothetical protein (pseudogene) 272631002194 [alpha]-methyl acyl-CoA racemase (pseudogene) 272631002195 short-chain alcohol dehydrogenase (pseudogene) 272631002196 probable drug transport protein (pseudogene) 272631002197 probable drug transporter (pseudogene) 272631002198 hypothetical protein (pseudogene). 272631002199 conserved hypothetical protein (pseudogene) 272631002200 dehydrogenase (pseudogene) 272631002201 conserved hypothetical protein (pseudogene) 272631002202 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272631002203 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272631002204 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631002205 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272631002206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272631002207 Coenzyme A binding pocket [chemical binding]; other site 272631002208 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272631002209 hypothetical protein (pseudogene). 272631002210 hypothetical protein (pseudogene) 272631002211 conserved hypothetical protein (pseudogene) 272631002212 conserved hypothetical protein (pseudogene) 272631002213 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 272631002214 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 272631002215 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 272631002216 homodimer interface [polypeptide binding]; other site 272631002217 active site 272631002218 TDP-binding site; other site 272631002219 acceptor substrate-binding pocket; other site 272631002220 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 272631002221 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 272631002222 recA bacterial DNA recombination protein; Region: RecA; cl19152 272631002223 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272631002224 protein-splicing catalytic site; other site 272631002225 thioester formation/cholesterol transfer; other site 272631002226 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 272631002227 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272631002228 recA bacterial DNA recombination protein; Region: RecA; cl19152 272631002229 protein-splicing catalytic site; other site 272631002230 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 272631002231 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 272631002232 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272631002233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272631002234 FeS/SAM binding site; other site 272631002235 hypothetical protein (pseudogene) 272631002236 serine-threonine protein kinase (pseudogene) 272631002237 conserved hypothetical protein (pseudogene) 272631002238 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 272631002239 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272631002240 diaminopimelate epimerase; Region: DapF; TIGR00652 272631002241 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272631002242 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272631002243 GTPases [General function prediction only]; Region: HflX; COG2262 272631002244 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272631002245 HflX GTPase family; Region: HflX; cd01878 272631002246 G1 box; other site 272631002247 GTP/Mg2+ binding site [chemical binding]; other site 272631002248 Switch I region; other site 272631002249 G2 box; other site 272631002250 G3 box; other site 272631002251 Switch II region; other site 272631002252 G4 box; other site 272631002253 G5 box; other site 272631002254 possible acyl-CoA dehydrogenase (pseudogene) 272631002255 possible transposase (pseudogene) 272631002256 conserved hypothetical protein (pseudogene) 272631002257 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 272631002258 LGFP repeat; Region: LGFP; pfam08310 272631002259 LGFP repeat; Region: LGFP; pfam08310 272631002260 LGFP repeat; Region: LGFP; pfam08310 272631002261 LGFP repeat; Region: LGFP; pfam08310 272631002262 LGFP repeat; Region: LGFP; pfam08310 272631002263 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 272631002264 LexA repressor; Validated; Region: PRK00215 272631002265 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272631002266 Catalytic site [active] 272631002267 LysM domain; Region: LysM; pfam01476 272631002268 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272631002269 ATP cone domain; Region: ATP-cone; pfam03477 272631002270 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 272631002271 heme-binding site [chemical binding]; other site 272631002272 conserved hypothetical protein (pseudogene) 272631002273 possible hydrolase (pseudogene) 272631002274 PAC2 family; Region: PAC2; pfam09754 272631002275 possible dehydrogenase (pseudogene) 272631002276 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 272631002277 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272631002278 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 272631002279 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 272631002280 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 272631002281 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272631002282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272631002283 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272631002284 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272631002285 DNA binding residues [nucleotide binding] 272631002286 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 272631002287 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 272631002288 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272631002289 hypothetical protein (pseudogene) 272631002290 hypothetical protein (pseudogene) 272631002291 conserved hypothetical protein (pseudogene) 272631002292 Mucin-like glycoprotein; Region: Mucin; pfam01456 272631002293 RNA polymerase sigma factor; Provisional; Region: PRK05901 272631002294 hypothetical protein; Provisional; Region: PHA03151 272631002295 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272631002296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272631002297 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272631002298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272631002299 DNA binding residues [nucleotide binding] 272631002300 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272631002301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272631002302 nucleotide binding site [chemical binding]; other site 272631002303 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 272631002304 active site 272631002305 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 272631002306 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 272631002307 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 272631002308 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272631002309 trimer interface [polypeptide binding]; other site 272631002310 active site 272631002311 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 272631002312 conserved hypothetical protein (pseudogene) 272631002313 conserved hypothetical protein (pseudogene) 272631002314 potassium uptake protein (pseudogene) 272631002315 hypothetical protein (pseudogene) 272631002316 possible membrane protein (pseudogene) 272631002317 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 272631002318 Citrate transporter; Region: CitMHS; pfam03600 272631002319 transmembrane helices; other site 272631002320 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 272631002321 FOG: CBS domain [General function prediction only]; Region: COG0517 272631002322 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 272631002323 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272631002324 TPP-binding site; other site 272631002325 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272631002326 PYR/PP interface [polypeptide binding]; other site 272631002327 dimer interface [polypeptide binding]; other site 272631002328 TPP binding site [chemical binding]; other site 272631002329 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272631002330 conserved hypothetical protein (pseudogene) 272631002331 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272631002332 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272631002333 catalytic site [active] 272631002334 putative active site [active] 272631002335 putative substrate binding site [chemical binding]; other site 272631002336 Helicase and RNase D C-terminal; Region: HRDC; smart00341 272631002337 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 272631002338 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631002339 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272631002340 substrate binding site [chemical binding]; other site 272631002341 active site 272631002342 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 272631002343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272631002344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631002345 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 272631002346 methyltransferase (pseudogene) 272631002347 conserved hypothetical protein (pseudogene) 272631002348 transposase (pseudogene) 272631002349 resolvase (pseudogene) 272631002350 conserved hypothetical protein (pseudogene) 272631002351 acyl-CoA synthetase; Validated; Region: PRK07787 272631002352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631002353 acyl-activating enzyme (AAE) consensus motif; other site 272631002354 AMP binding site [chemical binding]; other site 272631002355 active site 272631002356 CoA binding site [chemical binding]; other site 272631002357 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272631002358 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272631002359 PE family; Region: PE; pfam00934 272631002360 possible PPE-family protein (pseudogene) 272631002361 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 272631002362 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 272631002363 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 272631002364 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 272631002365 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 272631002366 putative trimer interface [polypeptide binding]; other site 272631002367 putative CoA binding site [chemical binding]; other site 272631002368 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 272631002369 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 272631002370 metal binding site [ion binding]; metal-binding site 272631002371 putative dimer interface [polypeptide binding]; other site 272631002372 conserved hypothetical protein (pseudogene) 272631002373 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 272631002374 acyl CoA-ligase (pseudogene) 272631002375 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272631002376 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272631002377 substrate binding pocket [chemical binding]; other site 272631002378 dimer interface [polypeptide binding]; other site 272631002379 inhibitor binding site; inhibition site 272631002380 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 272631002381 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272631002382 DivIVA domain; Region: DivI1A_domain; TIGR03544 272631002383 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 272631002384 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 272631002385 hypothetical protein (pseudogene) 272631002386 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 272631002387 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272631002388 ligand binding site; other site 272631002389 oligomer interface; other site 272631002390 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272631002391 dimer interface [polypeptide binding]; other site 272631002392 N-terminal domain interface [polypeptide binding]; other site 272631002393 sulfate 1 binding site; other site 272631002394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631002395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631002396 conserved hypothetical protein (pseudogene) 272631002397 probable integral membrane protein (pseudogene) 272631002398 probable ABC transmembrane transport protein (pseudogene) 272631002399 transcriptional regulator (pseudogene) 272631002400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631002401 S-adenosylmethionine binding site [chemical binding]; other site 272631002402 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 272631002403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272631002404 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272631002405 DNA binding residues [nucleotide binding] 272631002406 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272631002407 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272631002408 protein binding site [polypeptide binding]; other site 272631002409 sec-independent translocase; Provisional; Region: PRK03100 272631002410 Domain of unknown function DUF59; Region: DUF59; pfam01883 272631002411 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 272631002412 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272631002413 Walker A motif; other site 272631002414 possible membrane protein (pseudogene) 272631002415 hypothetical protein (pseudogene) 272631002416 hypothetical protein (pseudogene) 272631002417 hypothetical protein (pseudogene) 272631002418 hypothetical protein (pseudogene) 272631002419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272631002420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272631002421 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272631002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631002423 dimer interface [polypeptide binding]; other site 272631002424 conserved gate region; other site 272631002425 putative PBP binding loops; other site 272631002426 ABC-ATPase subunit interface; other site 272631002427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272631002428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631002429 dimer interface [polypeptide binding]; other site 272631002430 conserved gate region; other site 272631002431 putative PBP binding loops; other site 272631002432 ABC-ATPase subunit interface; other site 272631002433 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272631002434 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272631002435 Walker A/P-loop; other site 272631002436 ATP binding site [chemical binding]; other site 272631002437 Q-loop/lid; other site 272631002438 ABC transporter signature motif; other site 272631002439 Walker B; other site 272631002440 D-loop; other site 272631002441 H-loop/switch region; other site 272631002442 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272631002443 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 272631002444 oligomer interface [polypeptide binding]; other site 272631002445 metal binding site [ion binding]; metal-binding site 272631002446 metal binding site [ion binding]; metal-binding site 272631002447 putative Cl binding site [ion binding]; other site 272631002448 basic sphincter; other site 272631002449 hydrophobic gate; other site 272631002450 periplasmic entrance; other site 272631002451 malate dehydrogenase; Provisional; Region: PRK05442 272631002452 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 272631002453 NAD(P) binding site [chemical binding]; other site 272631002454 dimer interface [polypeptide binding]; other site 272631002455 malate binding site [chemical binding]; other site 272631002456 PE_PGRS-family protein (pseudogene) 272631002457 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272631002458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631002459 short chain dehydrogenase; Provisional; Region: PRK06181 272631002460 NAD(P) binding site [chemical binding]; other site 272631002461 active site 272631002462 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 272631002463 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272631002464 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272631002465 TPP-binding site [chemical binding]; other site 272631002466 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272631002467 dimer interface [polypeptide binding]; other site 272631002468 PYR/PP interface [polypeptide binding]; other site 272631002469 TPP binding site [chemical binding]; other site 272631002470 probable drug efflux protein (pseudogene) 272631002471 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 272631002472 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272631002473 RNase_H superfamily; Region: RNase_H_2; pfam13482 272631002474 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272631002475 AAA domain; Region: AAA_30; pfam13604 272631002476 AAA domain; Region: AAA_12; pfam13087 272631002477 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 272631002478 possible ATP-dependent DNA/RNA helicase (pseudogene) 272631002479 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272631002480 possible cytochrome P-450 (pseudogene) 272631002481 FAD binding domain; Region: FAD_binding_4; pfam01565 272631002482 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 272631002483 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272631002484 probable multidrug resistance pump (pseudogene) 272631002485 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 272631002486 Fe-S cluster binding site [ion binding]; other site 272631002487 DNA binding site [nucleotide binding] 272631002488 active site 272631002489 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 272631002490 conserved hypothetical protein (pseudogene) 272631002491 probable aminotransferase (pseudogene) 272631002492 amidase AMI2_MYCTU Q11056 (pseudogene) 272631002493 conserved hypothetical protein (pseudogene) 272631002494 similar to adenylate cyclases (pseudogene) 272631002495 hypothetical protein (pseudogene) 272631002496 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272631002497 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272631002498 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272631002499 Walker A/P-loop; other site 272631002500 ATP binding site [chemical binding]; other site 272631002501 Q-loop/lid; other site 272631002502 ABC transporter signature motif; other site 272631002503 Walker B; other site 272631002504 D-loop; other site 272631002505 H-loop/switch region; other site 272631002506 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272631002507 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272631002508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272631002509 Walker A/P-loop; other site 272631002510 ATP binding site [chemical binding]; other site 272631002511 Q-loop/lid; other site 272631002512 ABC transporter signature motif; other site 272631002513 Walker B; other site 272631002514 D-loop; other site 272631002515 H-loop/switch region; other site 272631002516 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 272631002517 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 272631002518 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272631002519 catalytic core [active] 272631002520 hypothetical protein (pseudogene) 272631002521 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272631002522 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272631002523 active site 272631002524 metal binding site [ion binding]; metal-binding site 272631002525 DNA binding site [nucleotide binding] 272631002526 AAA domain; Region: AAA_23; pfam13476 272631002527 Walker A/P-loop; other site 272631002528 ATP binding site [chemical binding]; other site 272631002529 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272631002530 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 272631002531 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272631002532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272631002533 Walker A/P-loop; other site 272631002534 ATP binding site [chemical binding]; other site 272631002535 Q-loop/lid; other site 272631002536 ABC transporter signature motif; other site 272631002537 Walker B; other site 272631002538 D-loop; other site 272631002539 H-loop/switch region; other site 272631002540 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272631002541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272631002542 Walker A/P-loop; other site 272631002543 ATP binding site [chemical binding]; other site 272631002544 Q-loop/lid; other site 272631002545 ABC transporter signature motif; other site 272631002546 Walker B; other site 272631002547 D-loop; other site 272631002548 H-loop/switch region; other site 272631002549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272631002550 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272631002551 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272631002552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631002553 dimer interface [polypeptide binding]; other site 272631002554 conserved gate region; other site 272631002555 putative PBP binding loops; other site 272631002556 ABC-ATPase subunit interface; other site 272631002557 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272631002558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631002559 dimer interface [polypeptide binding]; other site 272631002560 conserved gate region; other site 272631002561 putative PBP binding loops; other site 272631002562 ABC-ATPase subunit interface; other site 272631002563 conserved hypothetical protein (pseudogene) 272631002564 lipoprotein (pseudogene) 272631002565 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 272631002566 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272631002567 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272631002568 active site 272631002569 HIGH motif; other site 272631002570 KMSK motif region; other site 272631002571 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272631002572 tRNA binding surface [nucleotide binding]; other site 272631002573 anticodon binding site; other site 272631002574 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272631002575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272631002576 active site 272631002577 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272631002578 substrate binding site [chemical binding]; other site 272631002579 catalytic residues [active] 272631002580 dimer interface [polypeptide binding]; other site 272631002581 homoserine dehydrogenase; Provisional; Region: PRK06349 272631002582 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272631002583 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272631002584 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 272631002585 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 272631002586 homodimer interface [polypeptide binding]; other site 272631002587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631002588 catalytic residue [active] 272631002589 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 272631002590 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272631002591 transcription termination factor Rho; Provisional; Region: PRK12678 272631002592 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 272631002593 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272631002594 RNA binding site [nucleotide binding]; other site 272631002595 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272631002596 multimer interface [polypeptide binding]; other site 272631002597 Walker A motif; other site 272631002598 ATP binding site [chemical binding]; other site 272631002599 Walker B motif; other site 272631002600 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 272631002601 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272631002602 PCRF domain; Region: PCRF; pfam03462 272631002603 RF-1 domain; Region: RF-1; pfam00472 272631002604 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272631002605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631002606 S-adenosylmethionine binding site [chemical binding]; other site 272631002607 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 272631002608 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272631002609 Mg++ binding site [ion binding]; other site 272631002610 putative catalytic motif [active] 272631002611 substrate binding site [chemical binding]; other site 272631002612 Protein of unknown function (DUF475); Region: DUF475; cl17481 272631002613 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272631002614 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 272631002615 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272631002616 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 272631002617 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 272631002618 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272631002619 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 272631002620 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272631002621 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272631002622 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272631002623 beta subunit interaction interface [polypeptide binding]; other site 272631002624 Walker A motif; other site 272631002625 ATP binding site [chemical binding]; other site 272631002626 Walker B motif; other site 272631002627 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272631002628 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272631002629 core domain interface [polypeptide binding]; other site 272631002630 delta subunit interface [polypeptide binding]; other site 272631002631 epsilon subunit interface [polypeptide binding]; other site 272631002632 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272631002633 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272631002634 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272631002635 alpha subunit interaction interface [polypeptide binding]; other site 272631002636 Walker A motif; other site 272631002637 ATP binding site [chemical binding]; other site 272631002638 Walker B motif; other site 272631002639 inhibitor binding site; inhibition site 272631002640 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272631002641 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272631002642 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272631002643 gamma subunit interface [polypeptide binding]; other site 272631002644 epsilon subunit interface [polypeptide binding]; other site 272631002645 LBP interface [polypeptide binding]; other site 272631002646 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 272631002647 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272631002648 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 272631002649 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272631002650 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272631002651 hinge; other site 272631002652 active site 272631002653 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 272631002654 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 272631002655 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272631002656 DNA binding site [nucleotide binding] 272631002657 active site 272631002658 DNA-3-methyladenine glycosidase II (pseudogene) 272631002659 probable oxidoreductase (pseudogene) 272631002660 hypothetical protein (pseudogene) 272631002661 hypothetical protein; Provisional; Region: PRK03298 272631002662 hypothetical protein (pseudogene) 272631002663 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 272631002664 dimer interface [polypeptide binding]; other site 272631002665 substrate binding site [chemical binding]; other site 272631002666 metal binding site [ion binding]; metal-binding site 272631002667 putative acyltransferase; Provisional; Region: PRK05790 272631002668 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272631002669 dimer interface [polypeptide binding]; other site 272631002670 active site 272631002671 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 272631002672 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 272631002673 Tetratricopeptide repeat; Region: TPR_20; pfam14561 272631002674 1,4-[alpha]-glucan branching enzyme (pseudogene) 272631002675 hypothetical protein (pseudogene) 272631002676 possible glycogen phosphorylase (pseudogene) 272631002677 possible antibiotic efflux protein (pseudogene) 272631002678 conserved hypothetical protein (pseudogene) 272631002679 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 272631002680 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 272631002681 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 272631002682 putative active site pocket [active] 272631002683 cleavage site 272631002684 conserved hypothetical protein (pseudogene) 272631002685 conserved hypothetical protein (pseudogene) 272631002686 cysteine synthase B (pseudogene) 272631002687 Rhomboid family; Region: Rhomboid; pfam01694 272631002688 glutamate racemase; Provisional; Region: PRK00865 272631002689 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272631002690 ribonuclease PH; Reviewed; Region: rph; PRK00173 272631002691 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272631002692 hexamer interface [polypeptide binding]; other site 272631002693 active site 272631002694 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272631002695 active site 272631002696 dimerization interface [polypeptide binding]; other site 272631002697 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 272631002698 Glucitol operon activator [Transcription]; Region: GutM; COG4578 272631002699 possible 3-oxoacyl-[ACP] reductase (pseudogene) 272631002700 possible acyl-CoA dehydrogenase (pseudogene) 272631002701 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 272631002702 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 272631002703 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 272631002704 PPE family; Region: PPE; pfam00823 272631002705 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 272631002706 PE family; Region: PE; pfam00934 272631002707 zinc-containing alcohol dehydrogenase (pseudogene) 272631002708 probable cytochrome p450 (pseudogene) 272631002709 acyl-CoA synthase (pseudogene) 272631002710 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272631002711 Cytochrome P450; Region: p450; cl12078 272631002712 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 272631002713 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272631002714 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 272631002715 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272631002716 phosphate binding site [ion binding]; other site 272631002717 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 272631002718 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 272631002719 putative active site [active] 272631002720 putative catalytic site [active] 272631002721 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272631002722 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 272631002723 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 272631002724 putative NAD(P) binding site [chemical binding]; other site 272631002725 active site 272631002726 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 272631002727 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 272631002728 active site 272631002729 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272631002730 hypothetical protein; Provisional; Region: PRK08201 272631002731 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 272631002732 active site 272631002733 metal binding site [ion binding]; metal-binding site 272631002734 dimer interface [polypeptide binding]; other site 272631002735 conserved hypothetical protein (pseudogene) 272631002736 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 272631002737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272631002738 active site 272631002739 HIGH motif; other site 272631002740 nucleotide binding site [chemical binding]; other site 272631002741 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272631002742 active site 272631002743 KMSKS motif; other site 272631002744 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 272631002745 tRNA binding surface [nucleotide binding]; other site 272631002746 anticodon binding site; other site 272631002747 hypothetical protein (pseudogene) 272631002748 probable DNA-damage-inducible protein (pseudogene) 272631002749 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272631002750 active site 272631002751 homotetramer interface [polypeptide binding]; other site 272631002752 homodimer interface [polypeptide binding]; other site 272631002753 lipoprotein signal peptidase; Provisional; Region: PRK14764 272631002754 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272631002755 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272631002756 active site 272631002757 conserved hypothetical protein (pseudogene) 272631002758 lipoprotein (pseudogene) 272631002759 hemoglobin-like, oxygen carrier (pseudogene) 272631002760 probable fatty-acyl CoA reductase (pseudogene) 272631002761 probable ketoacyl reductase (pseudogene) 272631002762 conserved hypothetical protein (pseudogene) 272631002763 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272631002764 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 272631002765 active site 272631002766 PHP Thumb interface [polypeptide binding]; other site 272631002767 metal binding site [ion binding]; metal-binding site 272631002768 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272631002769 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272631002770 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272631002771 generic binding surface II; other site 272631002772 generic binding surface I; other site 272631002773 conserved hypothetical protein (pseudogene) 272631002774 threonine dehydratase; Validated; Region: PRK08639 272631002775 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272631002776 tetramer interface [polypeptide binding]; other site 272631002777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631002778 catalytic residue [active] 272631002779 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 272631002780 putative Ile/Val binding site [chemical binding]; other site 272631002781 [alpha]-amylase (pseudogene) 272631002782 probable glycogen debranching enzyme (pseudogene) 272631002783 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272631002784 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272631002785 NlpC/P60 family; Region: NLPC_P60; pfam00877 272631002786 hypothetical protein (pseudogene) 272631002787 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272631002788 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272631002789 inhibitor-cofactor binding pocket; inhibition site 272631002790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631002791 catalytic residue [active] 272631002792 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 272631002793 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 272631002794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272631002795 catalytic residue [active] 272631002796 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 272631002797 conserved hypothetical protein (pseudogene) 272631002798 biotin synthase; Validated; Region: PRK06256 272631002799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272631002800 FeS/SAM binding site; other site 272631002801 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 272631002802 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 272631002803 conserved hypothetical protein (pseudogene) 272631002804 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272631002805 nudix motif; other site 272631002806 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 272631002807 quinolinate synthetase; Provisional; Region: PRK09375 272631002808 L-aspartate oxidase; Provisional; Region: PRK07804 272631002809 L-aspartate oxidase; Provisional; Region: PRK06175 272631002810 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272631002811 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 272631002812 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272631002813 dimerization interface [polypeptide binding]; other site 272631002814 active site 272631002815 probable esterase (pseudogene) 272631002816 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631002817 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631002818 active site 272631002819 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 272631002820 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 272631002821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631002822 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 272631002823 Enoylreductase; Region: PKS_ER; smart00829 272631002824 NAD(P) binding site [chemical binding]; other site 272631002825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631002826 NAD(P) binding site [chemical binding]; other site 272631002827 short chain dehydrogenase; Region: adh_short; pfam00106 272631002828 active site 272631002829 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272631002830 Condensation domain; Region: Condensation; cl19241 272631002831 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 272631002832 MMPL family; Region: MMPL; pfam03176 272631002833 MMPL family; Region: MMPL; pfam03176 272631002834 PE-PPE domain; Region: PE-PPE; pfam08237 272631002835 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 272631002836 acyl-CoA synthetase; Validated; Region: PRK05850 272631002837 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272631002838 acyl-activating enzyme (AAE) consensus motif; other site 272631002839 active site 272631002840 polyketide synthase (pseudogene) 272631002841 polyketide synthase (chalcone synthase-like) (pseudogene) 272631002842 possible cytochrome P450 (pseudogene) 272631002843 Probable cytochrome p450 (pseudogene) 272631002844 Probable ABC transporter (pseudogene) 272631002845 probable ABC transporter (pseudogene) 272631002846 enoyl-CoA hydratase; Provisional; Region: PRK05864 272631002847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631002848 substrate binding site [chemical binding]; other site 272631002849 oxyanion hole (OAH) forming residues; other site 272631002850 trimer interface [polypeptide binding]; other site 272631002851 transcriptional regulator (LuxR/UhpA family) (pseudogene) 272631002852 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 272631002853 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 272631002854 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 272631002855 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272631002856 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272631002857 putative acyl-acceptor binding pocket; other site 272631002858 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 272631002859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 272631002860 putative acyl-acceptor binding pocket; other site 272631002861 hypothetical protein (pseudogene) 272631002862 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 272631002863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272631002864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272631002865 Walker A/P-loop; other site 272631002866 ATP binding site [chemical binding]; other site 272631002867 Q-loop/lid; other site 272631002868 ABC transporter signature motif; other site 272631002869 ABC transporter; Region: ABC_tran_2; pfam12848 272631002870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272631002871 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 272631002872 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 272631002873 conserved hypothetical protein (pseudogene) 272631002874 hypothetical protein (pseudogene) 272631002875 probable maltase [alpha]-glucosidase (pseudogene) 272631002876 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 272631002877 apolar tunnel; other site 272631002878 heme binding site [chemical binding]; other site 272631002879 dimerization interface [polypeptide binding]; other site 272631002880 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272631002881 active site 272631002882 conserved hypothetical protein (pseudogene) 272631002883 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272631002884 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272631002885 NAD binding site [chemical binding]; other site 272631002886 dimerization interface [polypeptide binding]; other site 272631002887 product binding site; other site 272631002888 substrate binding site [chemical binding]; other site 272631002889 zinc binding site [ion binding]; other site 272631002890 catalytic residues [active] 272631002891 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 272631002892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272631002893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631002894 homodimer interface [polypeptide binding]; other site 272631002895 catalytic residue [active] 272631002896 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272631002897 putative active site pocket [active] 272631002898 4-fold oligomerization interface [polypeptide binding]; other site 272631002899 metal binding residues [ion binding]; metal-binding site 272631002900 3-fold/trimer interface [polypeptide binding]; other site 272631002901 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272631002902 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 272631002903 putative active site [active] 272631002904 oxyanion strand; other site 272631002905 catalytic triad [active] 272631002906 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272631002907 catalytic residues [active] 272631002908 impA, inositol monophosphtase (pseudogene) 272631002909 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272631002910 substrate binding site [chemical binding]; other site 272631002911 glutamase interaction surface [polypeptide binding]; other site 272631002912 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 272631002913 possible membrane protein (pseudogene) 272631002914 serine-threonine protein kinase (pseudogene) 272631002915 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 272631002916 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272631002917 conserved hypothetical protein (bacterioferritin comigratory protein) (pseudogene) 272631002918 anthranilate synthase component I; Provisional; Region: PRK13571 272631002919 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272631002920 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272631002921 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 272631002922 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272631002923 active site 272631002924 ribulose/triose binding site [chemical binding]; other site 272631002925 phosphate binding site [ion binding]; other site 272631002926 substrate (anthranilate) binding pocket [chemical binding]; other site 272631002927 product (indole) binding pocket [chemical binding]; other site 272631002928 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272631002929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631002930 catalytic residue [active] 272631002931 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272631002932 substrate binding site [chemical binding]; other site 272631002933 active site 272631002934 catalytic residues [active] 272631002935 heterodimer interface [polypeptide binding]; other site 272631002936 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 272631002937 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 272631002938 pyruvate kinase; Provisional; Region: PRK06247 272631002939 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272631002940 domain interfaces; other site 272631002941 active site 272631002942 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 272631002943 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 272631002944 active site 272631002945 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 272631002946 catalytic triad [active] 272631002947 dimer interface [polypeptide binding]; other site 272631002948 conserved hypothetical protein (pseudogene) 272631002949 short-chain alcohol dehydrogenase family (pseudogene) 272631002950 ABC transporter (pseudogene) 272631002951 ABC transporter (pseudogene) 272631002952 cytochrome d ubiquinol oxidase subunit II (pseudogene) 272631002953 cytochrome bd-II oxidase subunit I (pseudogene) 272631002954 C-term similar eukaryotic adenylate/guanylate cyclases (pseudogene) 272631002955 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 272631002956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272631002957 active site 272631002958 phosphorylation site [posttranslational modification] 272631002959 intermolecular recognition site; other site 272631002960 dimerization interface [polypeptide binding]; other site 272631002961 ANTAR domain; Region: ANTAR; pfam03861 272631002962 lipid carrier protein (pseudogene) 272631002963 hypothetical protein; Provisional; Region: PRK07906 272631002964 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 272631002965 putative metal binding site [ion binding]; other site 272631002966 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272631002967 substrate binding site [chemical binding]; other site 272631002968 conserved hypothetical protein (pseudogene) 272631002969 transposase (pseudogene) 272631002970 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 272631002971 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 272631002972 quinone interaction residues [chemical binding]; other site 272631002973 active site 272631002974 catalytic residues [active] 272631002975 FMN binding site [chemical binding]; other site 272631002976 substrate binding site [chemical binding]; other site 272631002978 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272631002979 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272631002980 catalytic core [active] 272631002981 conserved hypothetical protein; Region: TIGR03847 272631002982 conserved hypothetical protein; Region: TIGR03843 272631002983 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272631002984 active site 272631002985 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 272631002986 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272631002987 active site 272631002988 nucleotide binding site [chemical binding]; other site 272631002989 HIGH motif; other site 272631002990 KMSKS motif; other site 272631002991 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 272631002992 putative tRNA binding surface [nucleotide binding]; other site 272631002993 oxidoreductase (pseudogene) 272631002994 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272631002995 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272631002996 PAC2 family; Region: PAC2; pfam09754 272631002997 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272631002998 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 272631002999 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 272631003000 substrate binding pocket [chemical binding]; other site 272631003001 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 272631003002 B12 binding site [chemical binding]; other site 272631003003 cobalt ligand [ion binding]; other site 272631003004 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 272631003005 PPE-family protein (pseudogene) 272631003006 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 272631003007 homodimer interface [polypeptide binding]; other site 272631003008 putative metal binding site [ion binding]; other site 272631003009 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 272631003010 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 272631003011 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 272631003012 hypothetical protein (pseudogene) 272631003013 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 272631003014 tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801 272631003015 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 272631003016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631003017 S-adenosylmethionine binding site [chemical binding]; other site 272631003018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 272631003019 proteasome ATPase; Region: pup_AAA; TIGR03689 272631003020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631003021 Walker A motif; other site 272631003022 ATP binding site [chemical binding]; other site 272631003023 Walker B motif; other site 272631003024 arginine finger; other site 272631003025 hypothetical protein (pseudogene) 272631003026 possible integral membrane protein (pseudogene) 272631003027 similar to phytoene dehydrogenase precursor (pseudogene) 272631003028 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 272631003029 Pup-like protein; Region: Pup; pfam05639 272631003030 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 272631003031 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 272631003032 active site 272631003033 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 272631003034 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 272631003035 active site 272631003036 conserved hypothetical protein (pseudogene) 272631003037 conserved hypothetical protein (pseudogene) 272631003038 conserved hypothetical protein (pseudogene) 272631003039 conserved hypothetical protein (pseudogene) 272631003040 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 272631003041 Predicted transcriptional regulator [Transcription]; Region: COG2378 272631003042 WYL domain; Region: WYL; pfam13280 272631003043 Predicted transcriptional regulator [Transcription]; Region: COG2378 272631003044 WYL domain; Region: WYL; pfam13280 272631003045 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 272631003046 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 272631003047 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 272631003048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272631003049 ATP binding site [chemical binding]; other site 272631003050 putative Mg++ binding site [ion binding]; other site 272631003051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272631003052 nucleotide binding region [chemical binding]; other site 272631003053 ATP-binding site [chemical binding]; other site 272631003054 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 272631003055 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 272631003056 partially similar to DNA polymerase I (pseudogene) 272631003057 cytoplasmic peptidase (pseudogene) 272631003058 conserved hypothetical protein (pseudogene) 272631003059 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 272631003060 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272631003061 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272631003062 TAP-like protein; Region: Abhydrolase_4; pfam08386 272631003063 hypothetical protein; Provisional; Region: PRK14059 272631003064 conserved hypothetical protein (pseudogene) 272631003065 conserved hypothetical protein (pseudogene) 272631003066 conserved hypothetical protein (pseudogene) 272631003067 transcriptional regulator (LuxR/UhpA family) (pseudogene) 272631003068 acyl-CoA synthetase; Validated; Region: PRK07868 272631003069 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 272631003070 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631003071 acyl-activating enzyme (AAE) consensus motif; other site 272631003072 AMP binding site [chemical binding]; other site 272631003073 active site 272631003074 CoA binding site [chemical binding]; other site 272631003075 Uncharacterized conserved protein [Function unknown]; Region: COG2835 272631003076 conserved hypothetical protein (pseudogene) 272631003077 probable transmembrane protein (pseudogene) 272631003078 probable ABC transporter (pseudogene) 272631003079 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 272631003080 active site 272631003081 DNA binding site [nucleotide binding] 272631003082 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272631003083 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272631003084 active site 272631003085 HIGH motif; other site 272631003086 dimer interface [polypeptide binding]; other site 272631003087 KMSKS motif; other site 272631003088 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272631003089 RNA binding surface [nucleotide binding]; other site 272631003090 conserved hypothetical protein (pseudogene) 272631003091 conserved hypothetical protein (pseudogene) 272631003092 hypothetical protein (pseudogene) 272631003093 probable hydrolase (pseudogene) 272631003094 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272631003095 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272631003096 RNA binding surface [nucleotide binding]; other site 272631003097 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272631003098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631003099 S-adenosylmethionine binding site [chemical binding]; other site 272631003100 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 272631003101 DNA repair protein RecN; Region: recN; TIGR00634 272631003102 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272631003103 Walker A/P-loop; other site 272631003104 ATP binding site [chemical binding]; other site 272631003105 Q-loop/lid; other site 272631003106 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272631003107 ABC transporter signature motif; other site 272631003108 Walker B; other site 272631003109 D-loop; other site 272631003110 H-loop/switch region; other site 272631003111 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 272631003112 Thiamine pyrophosphokinase; Region: TPK; cd07995 272631003113 active site 272631003114 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 272631003115 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 272631003116 CTP synthetase; Validated; Region: pyrG; PRK05380 272631003117 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272631003118 Catalytic site [active] 272631003119 active site 272631003120 UTP binding site [chemical binding]; other site 272631003121 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272631003122 active site 272631003123 putative oxyanion hole; other site 272631003124 catalytic triad [active] 272631003125 conserved hypothetical protein (pseudogene) 272631003126 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 272631003127 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 272631003128 active site 272631003129 Int/Topo IB signature motif; other site 272631003130 methyltransferase (pseudogene) 272631003131 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272631003132 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272631003133 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 272631003134 P-loop; other site 272631003135 Magnesium ion binding site [ion binding]; other site 272631003136 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 272631003137 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 272631003138 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272631003139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272631003140 RNA binding surface [nucleotide binding]; other site 272631003141 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 272631003142 active site 272631003143 cytidylate kinase; Provisional; Region: cmk; PRK00023 272631003144 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272631003145 CMP-binding site; other site 272631003146 The sites determining sugar specificity; other site 272631003147 GTP-binding protein Der; Reviewed; Region: PRK03003 272631003148 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272631003149 G1 box; other site 272631003150 GTP/Mg2+ binding site [chemical binding]; other site 272631003151 Switch I region; other site 272631003152 G2 box; other site 272631003153 Switch II region; other site 272631003154 G3 box; other site 272631003155 G4 box; other site 272631003156 G5 box; other site 272631003157 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272631003158 G1 box; other site 272631003159 GTP/Mg2+ binding site [chemical binding]; other site 272631003160 Switch I region; other site 272631003161 G2 box; other site 272631003162 G3 box; other site 272631003163 Switch II region; other site 272631003164 G4 box; other site 272631003165 G5 box; other site 272631003166 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272631003167 hypothetical protein (pseudogene) 272631003168 conserved hypothetical protein (pseudogene) 272631003169 transcriptional regulator (IclR family) (pseudogene) 272631003170 probable aminoglycoside 3'-phosphotransferases (pseudogene) 272631003171 hypothetical protein (pseudogene) 272631003172 conserved hypothetical protein (pseudogene) 272631003173 oxidoreductase, possible (pseudogene) 272631003174 DNA polymerase I; Region: pola; TIGR00593 272631003175 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272631003176 active site 272631003177 metal binding site 1 [ion binding]; metal-binding site 272631003178 putative 5' ssDNA interaction site; other site 272631003179 metal binding site 3; metal-binding site 272631003180 metal binding site 2 [ion binding]; metal-binding site 272631003181 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272631003182 putative DNA binding site [nucleotide binding]; other site 272631003183 putative metal binding site [ion binding]; other site 272631003184 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272631003185 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272631003186 active site 272631003187 DNA binding site [nucleotide binding] 272631003188 catalytic site [active] 272631003189 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 272631003190 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272631003191 RNA binding site [nucleotide binding]; other site 272631003192 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272631003193 RNA binding site [nucleotide binding]; other site 272631003194 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272631003195 RNA binding site [nucleotide binding]; other site 272631003196 S1 RNA binding domain; Region: S1; pfam00575 272631003197 RNA binding site [nucleotide binding]; other site 272631003198 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272631003199 ATP-binding [chemical binding]; other site 272631003200 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 272631003201 CoA-binding site [chemical binding]; other site 272631003202 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 272631003203 ABC transporter (pseudogene) 272631003204 serine-threonine protein kinase (pseudogene) 272631003205 excinuclease ABC subunit B; Provisional; Region: PRK05298 272631003206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272631003207 ATP binding site [chemical binding]; other site 272631003208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272631003209 nucleotide binding region [chemical binding]; other site 272631003210 ATP-binding site [chemical binding]; other site 272631003211 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272631003212 UvrB/uvrC motif; Region: UVR; pfam02151 272631003213 probable drug efflux protein (pseudogene) 272631003214 Predicted membrane protein [Function unknown]; Region: COG5305 272631003215 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272631003216 Ligand Binding Site [chemical binding]; other site 272631003217 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272631003218 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272631003219 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272631003220 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272631003221 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272631003222 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 272631003223 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 272631003224 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272631003225 dimer interface [polypeptide binding]; other site 272631003226 putative anticodon binding site; other site 272631003227 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272631003228 motif 1; other site 272631003229 dimer interface [polypeptide binding]; other site 272631003230 active site 272631003231 motif 2; other site 272631003232 motif 3; other site 272631003233 translation initiation factor IF-3; Region: infC; TIGR00168 272631003234 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272631003235 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272631003236 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272631003237 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272631003238 23S rRNA binding site [nucleotide binding]; other site 272631003239 L21 binding site [polypeptide binding]; other site 272631003240 L13 binding site [polypeptide binding]; other site 272631003241 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272631003242 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272631003243 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272631003244 conserved hypothetical protein (pseudogene) 272631003245 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272631003246 cyclase homology domain; Region: CHD; cd07302 272631003247 nucleotidyl binding site; other site 272631003248 metal binding site [ion binding]; metal-binding site 272631003249 dimer interface [polypeptide binding]; other site 272631003250 possible membrane protein (pseudogene) 272631003251 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272631003252 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272631003253 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272631003254 dimer interface [polypeptide binding]; other site 272631003255 motif 1; other site 272631003256 active site 272631003257 motif 2; other site 272631003258 motif 3; other site 272631003259 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272631003260 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272631003261 putative tRNA-binding site [nucleotide binding]; other site 272631003262 B3/4 domain; Region: B3_4; pfam03483 272631003263 tRNA synthetase B5 domain; Region: B5; smart00874 272631003264 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272631003265 dimer interface [polypeptide binding]; other site 272631003266 motif 1; other site 272631003267 motif 3; other site 272631003268 motif 2; other site 272631003269 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272631003270 PE-family protein (pseudogene) 272631003271 transposase(pseudogene) 272631003272 transposase(pseudogene) 272631003273 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 272631003274 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272631003275 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272631003276 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272631003277 heterotetramer interface [polypeptide binding]; other site 272631003278 active site pocket [active] 272631003279 cleavage site 272631003280 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272631003281 feedback inhibition sensing region; other site 272631003282 homohexameric interface [polypeptide binding]; other site 272631003283 nucleotide binding site [chemical binding]; other site 272631003284 N-acetyl-L-glutamate binding site [chemical binding]; other site 272631003285 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272631003286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272631003287 inhibitor-cofactor binding pocket; inhibition site 272631003288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631003289 catalytic residue [active] 272631003290 ornithine carbamoyltransferase; Provisional; Region: PRK00779 272631003291 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272631003292 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272631003293 arginine repressor; Provisional; Region: PRK03341 272631003294 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272631003295 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272631003296 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272631003297 ANP binding site [chemical binding]; other site 272631003298 Substrate Binding Site II [chemical binding]; other site 272631003299 Substrate Binding Site I [chemical binding]; other site 272631003300 argininosuccinate lyase; Provisional; Region: PRK00855 272631003301 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272631003302 active sites [active] 272631003303 tetramer interface [polypeptide binding]; other site 272631003304 PGRS-family protein(pseudogene) 272631003305 polyketide synthase (chalcone synthase-like) (pseudogene) 272631003306 polyketide synthase (pseudogene) 272631003307 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 272631003308 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 272631003309 putative catalytic residue [active] 272631003310 PAS domain S-box; Region: sensory_box; TIGR00229 272631003311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272631003312 putative active site [active] 272631003313 heme pocket [chemical binding]; other site 272631003314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272631003315 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272631003316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272631003317 putative active site [active] 272631003318 heme pocket [chemical binding]; other site 272631003319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272631003320 metal binding site [ion binding]; metal-binding site 272631003321 active site 272631003322 I-site; other site 272631003323 conserved hypothetical protein (pseudogene) 272631003324 hypothetical protein (pseudogene) 272631003325 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272631003326 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 272631003327 active site 272631003328 nucleophile elbow; other site 272631003329 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272631003330 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272631003331 Walker A/P-loop; other site 272631003332 ATP binding site [chemical binding]; other site 272631003333 Q-loop/lid; other site 272631003334 ABC transporter signature motif; other site 272631003335 Walker B; other site 272631003336 D-loop; other site 272631003337 H-loop/switch region; other site 272631003338 TOBE domain; Region: TOBE_2; pfam08402 272631003339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272631003340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631003341 dimer interface [polypeptide binding]; other site 272631003342 conserved gate region; other site 272631003343 putative PBP binding loops; other site 272631003344 ABC-ATPase subunit interface; other site 272631003345 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272631003346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631003347 dimer interface [polypeptide binding]; other site 272631003348 conserved gate region; other site 272631003349 putative PBP binding loops; other site 272631003350 ABC-ATPase subunit interface; other site 272631003351 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272631003352 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272631003353 ECF family sigma factor (pseudogene) 272631003354 DoxX-like family; Region: DoxX_2; pfam13564 272631003355 conserved hypothetical protein (pseudogene) 272631003356 pyrazinamide resistance/sensitivity (pseudogene) 272631003357 hypothetical protein (pseudogene) 272631003358 probable carboxylesterase (pseudogene) 272631003359 probable lipoprotein (pseudogene) 272631003360 conserved hypothetical protein (pseudogene) 272631003361 polyketide synthase (pseudogene) 272631003362 hypothetical protein (pseudogene) 272631003363 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 272631003364 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272631003365 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 272631003366 Ligand binding site; other site 272631003367 Putative Catalytic site; other site 272631003368 DXD motif; other site 272631003369 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 272631003370 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272631003371 putative active site [active] 272631003372 catalytic triad [active] 272631003373 putative dimer interface [polypeptide binding]; other site 272631003374 hypothetical protein (pseudogene) 272631003375 conserved hypothetical protein (pseudogene) 272631003376 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272631003377 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272631003378 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 272631003379 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 272631003380 cobalt insertion (pseudogene) 272631003381 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 272631003382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272631003383 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272631003384 DNA binding residues [nucleotide binding] 272631003385 precorrin reductase (pseudogene) 272631003386 precorrin-3 methylase (pseudogene) 272631003387 conserved hypothetical protein (pseudogene) 272631003388 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272631003389 catalytic core [active] 272631003390 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 272631003391 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272631003392 active site 272631003393 (T/H)XGH motif; other site 272631003394 conserved hypothetical protein (pseudogene) 272631003395 conserved hypothetical protein (pseudogene) 272631003396 conserved hypothetical protein (pseudogene) 272631003397 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272631003398 putative catalytic cysteine [active] 272631003399 possible monooxygenasemonoxygenase (pseudogene) 272631003400 hypothetical protein (pseudogene) 272631003401 ribokinase (pseudogene) 272631003402 conserved hypothetical protein (pseudogene) 272631003403 NAD synthetase; Reviewed; Region: nadE; PRK02628 272631003404 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 272631003405 multimer interface [polypeptide binding]; other site 272631003406 active site 272631003407 catalytic triad [active] 272631003408 protein interface 1 [polypeptide binding]; other site 272631003409 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272631003410 homodimer interface [polypeptide binding]; other site 272631003411 NAD binding pocket [chemical binding]; other site 272631003412 ATP binding pocket [chemical binding]; other site 272631003413 Mg binding site [ion binding]; other site 272631003414 active-site loop [active] 272631003415 gamma-glutamyl kinase; Provisional; Region: PRK05429 272631003416 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272631003417 nucleotide binding site [chemical binding]; other site 272631003418 homotetrameric interface [polypeptide binding]; other site 272631003419 putative phosphate binding site [ion binding]; other site 272631003420 putative allosteric binding site; other site 272631003421 PUA domain; Region: PUA; pfam01472 272631003422 GTPase CgtA; Reviewed; Region: obgE; PRK12296 272631003423 GTP1/OBG; Region: GTP1_OBG; pfam01018 272631003424 Obg GTPase; Region: Obg; cd01898 272631003425 G1 box; other site 272631003426 GTP/Mg2+ binding site [chemical binding]; other site 272631003427 Switch I region; other site 272631003428 G2 box; other site 272631003429 G3 box; other site 272631003430 Switch II region; other site 272631003431 G4 box; other site 272631003432 G5 box; other site 272631003433 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 272631003434 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272631003435 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272631003436 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 272631003437 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272631003438 homodimer interface [polypeptide binding]; other site 272631003439 oligonucleotide binding site [chemical binding]; other site 272631003440 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272631003441 Uncharacterized conserved protein [Function unknown]; Region: COG5134 272631003442 Nucleoside diphosphate kinase; Region: NDK; pfam00334 272631003443 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272631003444 active site 272631003445 multimer interface [polypeptide binding]; other site 272631003446 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 272631003447 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272631003448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272631003449 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272631003450 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272631003451 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272631003452 active site 272631003453 HIGH motif; other site 272631003454 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272631003455 KMSKS motif; other site 272631003456 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272631003457 tRNA binding surface [nucleotide binding]; other site 272631003458 anticodon binding site; other site 272631003459 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272631003460 conserved hypothetical protein (pseudogene) 272631003461 hypothetical protein (pseudogene) 272631003462 oxidoreductase, beta subunit (pseudogene) 272631003463 probable oxidoreductase alpha subunit (pseudogene) 272631003464 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272631003465 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272631003466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631003467 Walker A motif; other site 272631003468 ATP binding site [chemical binding]; other site 272631003469 Walker B motif; other site 272631003470 arginine finger; other site 272631003471 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272631003472 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 272631003473 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272631003474 oligomer interface [polypeptide binding]; other site 272631003475 active site residues [active] 272631003476 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272631003477 oligomer interface [polypeptide binding]; other site 272631003478 active site residues [active] 272631003479 trigger factor; Provisional; Region: tig; PRK01490 272631003480 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272631003481 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272631003482 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272631003483 probable esterase (pseudogene) 272631003484 probable DNA glycosylase, endonuclease VIII (pseudogene) 272631003485 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 272631003486 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272631003487 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 272631003488 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 272631003489 Zn binding site [ion binding]; other site 272631003490 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 272631003491 possible transport protein (pseudogene) 272631003492 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 272631003493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272631003494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631003495 homodimer interface [polypeptide binding]; other site 272631003496 catalytic residue [active] 272631003497 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272631003498 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 272631003499 2,4-Dienoyl-CoA Reductase (pseudogene) 272631003500 hypothetical protein (pseudogene) 272631003501 FO synthase; Reviewed; Region: fbiC; PRK09234 272631003502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272631003503 FeS/SAM binding site; other site 272631003504 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272631003505 FeS/SAM binding site; other site 272631003506 PE-family protein (pseudogene) 272631003507 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 272631003508 transcriptional regulator (pseudogene) 272631003509 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272631003510 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 272631003511 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272631003512 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 272631003513 G1 box; other site 272631003514 putative GEF interaction site [polypeptide binding]; other site 272631003515 GTP/Mg2+ binding site [chemical binding]; other site 272631003516 Switch I region; other site 272631003517 G2 box; other site 272631003518 G3 box; other site 272631003519 Switch II region; other site 272631003520 G4 box; other site 272631003521 G5 box; other site 272631003522 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272631003523 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272631003524 nitrate reductase [gamma] chain (pseudogene) 272631003525 nitrate reductase [delta] chain (pseudogene) 272631003526 nitrate reductase [beta] chain (pseudogene) 272631003527 nitrate reductase [alpha] subunit (pseudogene) 272631003528 MutT homologue (pseudogene) 272631003529 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 272631003530 aromatic arch; other site 272631003531 DCoH dimer interaction site [polypeptide binding]; other site 272631003532 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 272631003533 DCoH tetramer interaction site [polypeptide binding]; other site 272631003534 substrate binding site [chemical binding]; other site 272631003535 mannosyltransferase; Provisional; Region: pimE; PRK13375 272631003536 hypothetical protein; Region: PHA02030 272631003537 large tegument protein UL36; Provisional; Region: PHA03247 272631003538 hypothetical protein (pseudogene) 272631003539 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 272631003540 hypothetical protein (pseudogene) 272631003541 transcriptional regulator (GntR family) (pseudogene) 272631003542 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 272631003543 NAD+ binding site [chemical binding]; other site 272631003544 substrate binding site [chemical binding]; other site 272631003545 Zn binding site [ion binding]; other site 272631003546 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272631003547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272631003548 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272631003549 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272631003550 dimer interface [polypeptide binding]; other site 272631003551 active site 272631003552 catalytic residue [active] 272631003553 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 272631003554 hypothetical protein (pseudogene) 272631003555 type I restriction/modification system DNA (pseudogene) 272631003556 Winged helix DNA-binding domain; Region: HTH_42; cl19833 272631003557 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272631003558 folate binding site [chemical binding]; other site 272631003559 NADP+ binding site [chemical binding]; other site 272631003560 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272631003561 dimerization interface [polypeptide binding]; other site 272631003562 active site 272631003563 hypothetical protein (pseudogene) 272631003564 acyl-CoA dehydrogenase (pseudogene) 272631003565 3-oxoacyl-[ACP] reductase (pseudogene) 272631003566 acyl-CoA synthase (pseudogene) 272631003567 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272631003568 dihydrodipicolinate reductase (pseudogene) 272631003569 REP-family protein (pseudogene) 272631003570 probable oxidoreductase (pseudogene) 272631003571 hypothetical protein (pseudogene) 272631003572 transcriptional regulator (Lrp/AsnC family) (pseudogene) 272631003573 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272631003574 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 272631003575 hexamer interface [polypeptide binding]; other site 272631003576 ligand binding site [chemical binding]; other site 272631003577 putative active site [active] 272631003578 NAD(P) binding site [chemical binding]; other site 272631003579 PPE-family protein (pseudogene) 272631003580 PE_PGRS-family protein (pseudogene) 272631003581 hypothetical protein (pseudogene) 272631003582 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 272631003583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272631003584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631003585 Walker A motif; other site 272631003586 ATP binding site [chemical binding]; other site 272631003587 Walker B motif; other site 272631003588 arginine finger; other site 272631003589 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 272631003590 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 272631003591 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272631003592 catalytic residues [active] 272631003593 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 272631003594 active site 272631003595 catalytic residues [active] 272631003596 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 272631003597 EspG family; Region: ESX-1_EspG; pfam14011 272631003598 Probable ferredoxin (pseudogene) 272631003599 Probable member of the cytochrome P450 (pseudogene) 272631003600 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 272631003601 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631003602 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 272631003603 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631003604 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631003605 Protein of unknown function (DUF690); Region: DUF690; pfam05108 272631003606 probable 4-[alpha]-glucanotransferase (pseudogene) 272631003607 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 272631003608 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272631003609 RNA binding site [nucleotide binding]; other site 272631003610 active site 272631003611 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 272631003612 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 272631003613 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272631003614 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272631003615 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272631003616 active site 272631003617 metal binding site [ion binding]; metal-binding site 272631003618 hypothetical protein (pseudogene) 272631003619 conserved hypothetical protein (pseudogene) 272631003620 conserved hypothetical protein (pseudogene) 272631003621 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631003622 prolyl-tRNA synthetase; Provisional; Region: PRK08661 272631003623 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 272631003624 dimer interface [polypeptide binding]; other site 272631003625 motif 1; other site 272631003626 active site 272631003627 motif 2; other site 272631003628 motif 3; other site 272631003629 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 272631003630 anticodon binding site; other site 272631003631 zinc-binding site [ion binding]; other site 272631003632 conserved hypothetical protein (pseudogene) 272631003633 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272631003634 translation initiation factor IF-2; Validated; Region: infB; PRK05306 272631003635 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272631003636 Proline-rich; Region: Pro-rich; pfam15240 272631003637 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272631003638 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272631003639 G1 box; other site 272631003640 putative GEF interaction site [polypeptide binding]; other site 272631003641 GTP/Mg2+ binding site [chemical binding]; other site 272631003642 Switch I region; other site 272631003643 G2 box; other site 272631003644 G3 box; other site 272631003645 Switch II region; other site 272631003646 G4 box; other site 272631003647 G5 box; other site 272631003648 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272631003649 Translation-initiation factor 2; Region: IF-2; pfam11987 272631003650 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272631003651 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 272631003652 putative RNA binding cleft [nucleotide binding]; other site 272631003653 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272631003654 NusA N-terminal domain; Region: NusA_N; pfam08529 272631003655 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272631003656 RNA binding site [nucleotide binding]; other site 272631003657 homodimer interface [polypeptide binding]; other site 272631003658 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272631003659 G-X-X-G motif; other site 272631003660 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272631003661 G-X-X-G motif; other site 272631003662 conserved hypothetical protein (pseudogene) 272631003663 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272631003664 dinuclear metal binding motif [ion binding]; other site 272631003665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272631003666 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272631003667 putative substrate translocation pore; other site 272631003668 multifunctional enzyme, siroheme synthase (pseudogene) 272631003669 cobyrinic acid a,c-diamide synthase (pseudogene) 272631003670 cob(I)alamin adenosyltransferase (pseudogene) 272631003671 possible magnesium-chelatase (pseudogene) 272631003672 conserved hypothetical protein (pseudogene) 272631003673 conserved hypothetical protein (pseudogene) 272631003674 hypothetical protein (pseudogene) 272631003675 glutathione reductase homologue (pseudogene) 272631003676 probable nickel transport protein (pseudogene) 272631003677 Sulfatase; Region: Sulfatase; cl19157 272631003678 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 272631003679 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272631003680 catalytic triad [active] 272631003681 proable glutamine synthase (pseudogene) 272631003682 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272631003683 active site 272631003684 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 272631003685 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272631003686 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272631003687 conserved hypothetical protein (pseudogene) 272631003688 conserved hypothetical protein (pseudogene) 272631003689 hypothetical protein (pseudogene) 272631003690 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272631003691 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 272631003692 RIP metalloprotease RseP; Region: TIGR00054 272631003693 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272631003694 active site 272631003695 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272631003696 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272631003697 putative substrate binding region [chemical binding]; other site 272631003698 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272631003699 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272631003700 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272631003701 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272631003702 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 272631003703 possible mercury resistance transport system (pseudogene) 272631003704 hypothetical protein Mpt53 (pseudogene) 272631003705 conserved hypothetical protein (pseudogene) 272631003706 conserved hypothetical protein (pseudogene) 272631003707 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 272631003708 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272631003709 hinge region; other site 272631003710 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272631003711 putative nucleotide binding site [chemical binding]; other site 272631003712 uridine monophosphate binding site [chemical binding]; other site 272631003713 homohexameric interface [polypeptide binding]; other site 272631003714 two-component response regulator (pseudogene) 272631003715 hypothetical protein (pseudogene) 272631003716 multidrug resistance protein (pseudogene) 272631003717 possible regulatory protein (pseudogene) 272631003718 amidase; Provisional; Region: PRK07869 272631003719 elongation factor Ts; Provisional; Region: tsf; PRK09377 272631003720 UBA/TS-N domain; Region: UBA; pfam00627 272631003721 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272631003722 rRNA interaction site [nucleotide binding]; other site 272631003723 S8 interaction site; other site 272631003724 putative laminin-1 binding site; other site 272631003725 hypothetical protein (pseudogene) 272631003726 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272631003727 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272631003728 active site 272631003729 DNA binding site [nucleotide binding] 272631003730 Int/Topo IB signature motif; other site 272631003731 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272631003732 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272631003733 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 272631003734 hypothetical protein (pseudogene) 272631003735 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 272631003736 affects formate dehydrogenase-N (pseudogene) 272631003737 molybdopterin-containing oxidoreductase (pseudogene) 272631003738 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 272631003739 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272631003740 RNA/DNA hybrid binding site [nucleotide binding]; other site 272631003741 active site 272631003742 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272631003743 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272631003744 Catalytic site [active] 272631003745 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 272631003746 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272631003747 Slight similarity to beta-lactamase (pseudogene) 272631003748 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272631003749 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272631003750 RimM N-terminal domain; Region: RimM; pfam01782 272631003751 PRC-barrel domain; Region: PRC; pfam05239 272631003752 hypothetical protein; Provisional; Region: PRK02821 272631003753 G-X-X-G motif; other site 272631003754 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 272631003755 ribosomal protein S16; Region: S16; TIGR00002 272631003756 conserved hypothetical protein (pseudogene) 272631003757 serine-threonine protein kinase (pseudogene) 272631003758 conserved hypothetical protein (pseudogene) 272631003759 signal recognition particle protein; Provisional; Region: PRK10867 272631003760 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272631003761 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272631003762 P loop; other site 272631003763 GTP binding site [chemical binding]; other site 272631003764 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272631003765 heat shock protein 90; Provisional; Region: PRK05218 272631003766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272631003767 ATP binding site [chemical binding]; other site 272631003768 Mg2+ binding site [ion binding]; other site 272631003769 G-X-G motif; other site 272631003770 Hsp90 protein; Region: HSP90; pfam00183 272631003771 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 272631003772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272631003773 ATP binding site [chemical binding]; other site 272631003774 putative Mg++ binding site [ion binding]; other site 272631003775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 272631003776 Helicase conserved C-terminal domain; Region: Helicase_C; cl17351 272631003777 uridylyltransferase (pseudogene) 272631003778 nitrogen regulatory protein (pseudogene) 272631003779 ammonium transporter (pseudogene) 272631003780 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272631003781 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272631003782 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 272631003783 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272631003784 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272631003785 Walker A/P-loop; other site 272631003786 ATP binding site [chemical binding]; other site 272631003787 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272631003788 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272631003789 ABC transporter signature motif; other site 272631003790 Walker B; other site 272631003791 D-loop; other site 272631003792 H-loop/switch region; other site 272631003793 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 272631003794 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272631003795 metal binding triad; other site 272631003796 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272631003797 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272631003798 metal binding triad; other site 272631003799 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272631003800 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272631003801 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272631003802 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272631003803 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 272631003804 TAP-like protein; Region: Abhydrolase_4; pfam08386 272631003805 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 272631003806 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272631003807 TAP-like protein; Region: Abhydrolase_4; pfam08386 272631003808 conserved hypothetical protein (pseudogene) 272631003809 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272631003810 oligomerization interface [polypeptide binding]; other site 272631003811 active site 272631003812 metal binding site [ion binding]; metal-binding site 272631003813 hypothetical protein (pseudogene) 272631003814 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 272631003815 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 272631003816 RNA/DNA hybrid binding site [nucleotide binding]; other site 272631003817 active site 272631003818 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272631003819 catalytic core [active] 272631003820 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 272631003821 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272631003822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 272631003823 aminotransferase (pseudogene) 272631003824 hypothetical protein (pseudogene) 272631003825 hypothetical protein (pseudogene) 272631003826 low molecular weight protein-tyrosine-phosphatase (pseudogene) 272631003827 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 272631003828 cobinamide synthase (pseudogene) 272631003829 hypothetical protein (pseudogene) 272631003830 conserved hypothetical protein (pseudogene) 272631003831 member of AhpC/TSA family (pseudogene) 272631003832 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 272631003833 conserved hypothetical protein (pseudogene) 272631003834 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 272631003835 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 272631003836 dimer interface [polypeptide binding]; other site 272631003837 TPP-binding site [chemical binding]; other site 272631003838 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 272631003839 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272631003840 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272631003841 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272631003842 acyl carrier protein; Provisional; Region: acpP; PRK00982 272631003843 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 272631003844 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272631003845 dimer interface [polypeptide binding]; other site 272631003846 active site 272631003847 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 272631003848 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272631003849 dimer interface [polypeptide binding]; other site 272631003850 active site 272631003851 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272631003852 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272631003853 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272631003854 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272631003855 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272631003856 DNA binding site [nucleotide binding] 272631003857 catalytic residue [active] 272631003858 H2TH interface [polypeptide binding]; other site 272631003859 putative catalytic residues [active] 272631003860 turnover-facilitating residue; other site 272631003861 intercalation triad [nucleotide binding]; other site 272631003862 8OG recognition residue [nucleotide binding]; other site 272631003863 putative reading head residues; other site 272631003864 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272631003865 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272631003866 ribonuclease III; Reviewed; Region: rnc; PRK00102 272631003867 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272631003868 dimerization interface [polypeptide binding]; other site 272631003869 active site 272631003870 metal binding site [ion binding]; metal-binding site 272631003871 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272631003872 dsRNA binding site [nucleotide binding]; other site 272631003873 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 272631003874 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272631003875 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272631003876 integral membrane protein (pseudogene) 272631003877 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272631003878 active site 272631003879 (T/H)XGH motif; other site 272631003880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631003881 S-adenosylmethionine binding site [chemical binding]; other site 272631003882 pyruvate carboxylase (pseudogene) 272631003883 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 272631003884 putative active site [active] 272631003885 redox center [active] 272631003886 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272631003887 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 272631003888 catalytic residues [active] 272631003889 probable lipase/esterase (pseudogene) 272631003890 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272631003891 active site 272631003892 catalytic tetrad [active] 272631003893 hypothetical protein (pseudogene) 272631003894 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 272631003895 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272631003896 generic binding surface II; other site 272631003897 ssDNA binding site; other site 272631003898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272631003899 ATP binding site [chemical binding]; other site 272631003900 putative Mg++ binding site [ion binding]; other site 272631003901 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272631003902 nucleotide binding region [chemical binding]; other site 272631003903 ATP-binding site [chemical binding]; other site 272631003904 conserved hypothetical protein (pseudogene) 272631003905 conserved hypothetical protein (pseudogene) 272631003906 50S ribosomal protein L28 (pseudogene) 272631003907 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272631003908 ligand binding site [chemical binding]; other site 272631003909 active site 272631003910 UGI interface [polypeptide binding]; other site 272631003911 catalytic site [active] 272631003912 thiamine monophosphate kinase; Provisional; Region: PRK05731 272631003913 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 272631003914 ATP binding site [chemical binding]; other site 272631003915 dimerization interface [polypeptide binding]; other site 272631003916 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 272631003917 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272631003918 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272631003919 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272631003920 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272631003921 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272631003922 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272631003923 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 272631003924 polyphosphate kinase; Provisional; Region: PRK05443 272631003925 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272631003926 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272631003927 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 272631003928 putative domain interface [polypeptide binding]; other site 272631003929 putative active site [active] 272631003930 catalytic site [active] 272631003931 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272631003932 putative active site [active] 272631003933 catalytic site [active] 272631003934 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 272631003935 active site 272631003936 Ap6A binding site [chemical binding]; other site 272631003937 nudix motif; other site 272631003938 metal binding site [ion binding]; metal-binding site 272631003939 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272631003940 catalytic core [active] 272631003941 histone-like DNA-binding protein HU; Region: HU; cd13831 272631003942 dimer interface [polypeptide binding]; other site 272631003943 DNA binding site [nucleotide binding] 272631003944 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272631003945 substrate binding site [chemical binding]; other site 272631003946 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272631003947 substrate binding site [chemical binding]; other site 272631003948 ligand binding site [chemical binding]; other site 272631003949 transcriptional regulator (IclR family) (pseudogene) 272631003950 hypothetical protein (pseudogene) 272631003951 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272631003952 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272631003953 active site 272631003954 HIGH motif; other site 272631003955 KMSKS motif; other site 272631003956 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 272631003957 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 272631003958 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272631003959 probable fluoroquinolone efflux protein (pseudogene) 272631003960 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 272631003961 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 272631003962 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 272631003963 ligand binding site [chemical binding]; other site 272631003964 NAD binding site [chemical binding]; other site 272631003965 dimerization interface [polypeptide binding]; other site 272631003966 catalytic site [active] 272631003967 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 272631003968 putative L-serine binding site [chemical binding]; other site 272631003969 dehydrogenase (pseudogene) 272631003970 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272631003971 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272631003972 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272631003973 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272631003974 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272631003975 putative valine binding site [chemical binding]; other site 272631003976 dimer interface [polypeptide binding]; other site 272631003977 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272631003978 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 272631003979 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272631003980 PYR/PP interface [polypeptide binding]; other site 272631003981 dimer interface [polypeptide binding]; other site 272631003982 TPP binding site [chemical binding]; other site 272631003983 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272631003984 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272631003985 TPP-binding site [chemical binding]; other site 272631003986 dimer interface [polypeptide binding]; other site 272631003987 hypothetical protein (pseudogene) 272631003988 Predicted membrane protein [Function unknown]; Region: COG2259 272631003989 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272631003990 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272631003991 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272631003992 GatB domain; Region: GatB_Yqey; pfam02637 272631003993 6-phosphofructokinase; Provisional; Region: PRK03202 272631003994 active site 272631003995 ADP/pyrophosphate binding site [chemical binding]; other site 272631003996 dimerization interface [polypeptide binding]; other site 272631003997 allosteric effector site; other site 272631003998 fructose-1,6-bisphosphate binding site; other site 272631003999 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272631004000 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 272631004001 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272631004002 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272631004003 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272631004004 nucleotide binding pocket [chemical binding]; other site 272631004005 K-X-D-G motif; other site 272631004006 catalytic site [active] 272631004007 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272631004008 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272631004009 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272631004010 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272631004011 Dimer interface [polypeptide binding]; other site 272631004012 BRCT sequence motif; other site 272631004013 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 272631004014 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272631004015 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272631004016 Ligand Binding Site [chemical binding]; other site 272631004017 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272631004018 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272631004019 catalytic residue [active] 272631004020 some similarity to acyltransferase Q59601 (pseudogene) 272631004021 hypothetical protein (pseudogene) 272631004022 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 272631004023 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272631004024 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272631004025 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272631004026 Ligand binding site [chemical binding]; other site 272631004027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631004028 S-adenosylmethionine binding site [chemical binding]; other site 272631004029 Uncharacterized conserved protein [Function unknown]; Region: COG1543 272631004030 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 272631004031 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 272631004032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272631004033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272631004034 unknown membrane protein (pseudogene) 272631004035 conserved hypothetical protein (pseudogene) 272631004036 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272631004037 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 272631004038 trimer interface [polypeptide binding]; other site 272631004039 active site 272631004040 substrate binding site [chemical binding]; other site 272631004041 CoA binding site [chemical binding]; other site 272631004042 FOG: WD40-like repeat [Function unknown]; Region: COG1520 272631004043 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 272631004044 active site 272631004045 probable hypothetical protein (pseudogene) 272631004046 hypothetical protein (pseudogene) 272631004047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631004048 S-adenosylmethionine binding site [chemical binding]; other site 272631004049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631004050 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 272631004051 substrate binding site [chemical binding]; other site 272631004052 oxyanion hole (OAH) forming residues; other site 272631004053 trimer interface [polypeptide binding]; other site 272631004054 hypothetical protein (pseudogene) 272631004055 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 272631004056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272631004057 Walker A/P-loop; other site 272631004058 ATP binding site [chemical binding]; other site 272631004059 ABC transporter signature motif; other site 272631004060 Walker B; other site 272631004061 D-loop; other site 272631004062 H-loop/switch region; other site 272631004063 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 272631004064 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272631004065 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 272631004066 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272631004067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272631004068 motif II; other site 272631004069 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272631004070 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272631004071 D-pathway; other site 272631004072 Putative ubiquinol binding site [chemical binding]; other site 272631004073 Low-spin heme (heme b) binding site [chemical binding]; other site 272631004074 Putative water exit pathway; other site 272631004075 Binuclear center (heme o3/CuB) [ion binding]; other site 272631004076 K-pathway; other site 272631004077 Putative proton exit pathway; other site 272631004078 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272631004079 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272631004080 siderophore binding site; other site 272631004081 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272631004082 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 272631004083 putative NAD(P) binding site [chemical binding]; other site 272631004084 putative substrate binding site [chemical binding]; other site 272631004085 catalytic Zn binding site [ion binding]; other site 272631004086 structural Zn binding site [ion binding]; other site 272631004087 dimer interface [polypeptide binding]; other site 272631004088 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272631004089 dimer interface [polypeptide binding]; other site 272631004090 putative radical transfer pathway; other site 272631004091 diiron center [ion binding]; other site 272631004092 tyrosyl radical; other site 272631004093 Probable monooxygenase (pseudogene) 272631004094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631004095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631004096 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 272631004097 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272631004098 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272631004099 active site 272631004100 dimer interface [polypeptide binding]; other site 272631004101 catalytic residues [active] 272631004102 effector binding site; other site 272631004103 R2 peptide binding site; other site 272631004104 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 272631004105 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 272631004106 catalytic residues [active] 272631004107 conserved hypothetical protein (pseudogene) 272631004108 transcriptional regulator (pseudogene) 272631004109 DNA-damage-inducible protein (pseudogene) 272631004110 short chain dehydrogenase; Provisional; Region: PRK05650 272631004111 classical (c) SDRs; Region: SDR_c; cd05233 272631004112 NAD(P) binding site [chemical binding]; other site 272631004113 active site 272631004114 transcriptional regulator (pseudogene) 272631004115 possible lanosterol 14-alpha-demethylases (pseudogene) 272631004116 PE-family protein (pseudogene) 272631004117 transcriptional regulator (GntR family) (pseudogene) 272631004118 acyl-CoA dehydrogenase (pseudogene) 272631004119 short-chain alcohol dehydrogenase (pseudogene) 272631004120 DNA ligase (pseudogene) 272631004121 starvation-induced stress response protein (pseudogene) 272631004123 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272631004124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272631004125 metal binding site [ion binding]; metal-binding site 272631004126 active site 272631004127 I-site; other site 272631004128 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272631004129 hypothetical protein; Provisional; Region: PRK07877 272631004130 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 272631004131 ATP binding site [chemical binding]; other site 272631004132 substrate interface [chemical binding]; other site 272631004133 Nitroreductase family; Region: Nitroreductase; pfam00881 272631004134 FMN binding site [chemical binding]; other site 272631004135 dimer interface [polypeptide binding]; other site 272631004136 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272631004137 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272631004138 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 272631004139 nucleotidyl binding site; other site 272631004140 metal binding site [ion binding]; metal-binding site 272631004141 Predicted ATPase [General function prediction only]; Region: COG3903 272631004142 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272631004143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272631004144 DNA binding residues [nucleotide binding] 272631004145 dimerization interface [polypeptide binding]; other site 272631004146 PPE-family protein (pseudogene) 272631004147 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 272631004148 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272631004149 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 272631004150 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272631004151 transcriptional regulator (pseudogene) 272631004152 probable oxidoreductase (pseudogene) 272631004153 phosphoglucomutase (pseudogene) 272631004154 integrase (pseudogene) 272631004155 possible transport protein (pseudogene) 272631004156 transport protein (pseudogene) 272631004157 hypothetical protein (pseudogene) 272631004158 conserved hypothetical protein (pseudogene) 272631004159 conserved hypothetical protein (pseudogene) 272631004160 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272631004161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631004162 dimer interface [polypeptide binding]; other site 272631004163 conserved gate region; other site 272631004164 putative PBP binding loops; other site 272631004165 ABC-ATPase subunit interface; other site 272631004166 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272631004167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631004168 dimer interface [polypeptide binding]; other site 272631004169 conserved gate region; other site 272631004170 putative PBP binding loops; other site 272631004171 ABC-ATPase subunit interface; other site 272631004172 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272631004173 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272631004174 hypothetical protein (pseudogene) 272631004175 arginine/ornithine transporter (pseudogene) 272631004176 ornithine aminotransferase (pseudogene) 272631004177 ornithine aminotransferase (pseudogene) 272631004178 conserved hypothetical protein (pseudogene) 272631004179 transcriptional regulator (Lrp/AsnC family) (pseudogene) 272631004180 glycerol-3-phosphate dehydrogenase (pseudogene) 272631004181 transcriptional regulator (pseudogene) 272631004182 conserved hypothetical protein (pseudogene) 272631004183 conserved hypothetical protein (pseudogene) 272631004184 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 272631004185 Beta-lactamase; Region: Beta-lactamase; pfam00144 272631004186 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272631004187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631004188 S-adenosylmethionine binding site [chemical binding]; other site 272631004189 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 272631004190 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 272631004191 NAD binding site [chemical binding]; other site 272631004192 catalytic Zn binding site [ion binding]; other site 272631004193 substrate binding site [chemical binding]; other site 272631004194 structural Zn binding site [ion binding]; other site 272631004195 hypothetical protein (pseudogene) 272631004196 apolipoprotein N-acyltransferase-a (pseudogene) 272631004197 Probable cytochrome P-450 (pseudogene) 272631004198 conserved hypothetical protein (pseudogene) 272631004199 hypothetical protein (pseudogene) 272631004200 YacP-like NYN domain; Region: NYN_YacP; cl01491 272631004201 probable Na+/H+ exchanger (pseudogene) 272631004202 Predicted ATPase [General function prediction only]; Region: COG4637 272631004203 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 272631004204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272631004205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631004206 homodimer interface [polypeptide binding]; other site 272631004207 catalytic residue [active] 272631004208 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272631004209 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272631004210 putative dimer interface [polypeptide binding]; other site 272631004211 probable esterase (pseudogene) 272631004212 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 272631004213 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 272631004214 Walker A; other site 272631004215 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 272631004216 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 272631004217 active site 272631004218 substrate binding site [chemical binding]; other site 272631004219 coenzyme B12 binding site [chemical binding]; other site 272631004220 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 272631004221 B12 binding site [chemical binding]; other site 272631004222 cobalt ligand [ion binding]; other site 272631004223 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 272631004224 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 272631004225 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 272631004226 probable membrane protein (pseudogene) 272631004227 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272631004228 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 272631004229 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 272631004230 structural protein; Region: PHA01972 272631004231 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 272631004232 ferrochelatase; Reviewed; Region: hemH; PRK00035 272631004233 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272631004234 C-terminal domain interface [polypeptide binding]; other site 272631004235 active site 272631004236 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272631004237 active site 272631004238 N-terminal domain interface [polypeptide binding]; other site 272631004239 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272631004240 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272631004241 NAD binding site [chemical binding]; other site 272631004242 homotetramer interface [polypeptide binding]; other site 272631004243 homodimer interface [polypeptide binding]; other site 272631004244 substrate binding site [chemical binding]; other site 272631004245 active site 272631004246 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272631004247 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 272631004248 NAD(P) binding site [chemical binding]; other site 272631004249 homotetramer interface [polypeptide binding]; other site 272631004250 homodimer interface [polypeptide binding]; other site 272631004251 active site 272631004252 hypothetical protein; Provisional; Region: PRK13685 272631004253 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272631004254 metal ion-dependent adhesion site (MIDAS); other site 272631004255 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272631004256 Protein of unknown function DUF58; Region: DUF58; pfam01882 272631004257 MoxR-like ATPases [General function prediction only]; Region: COG0714 272631004258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631004259 Walker A motif; other site 272631004260 ATP binding site [chemical binding]; other site 272631004261 Walker B motif; other site 272631004262 arginine finger; other site 272631004263 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272631004264 NlpC/P60 family; Region: NLPC_P60; pfam00877 272631004265 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272631004266 NlpC/P60 family; Region: NLPC_P60; pfam00877 272631004267 aconitate hydratase; Validated; Region: PRK09277 272631004268 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 272631004269 substrate binding site [chemical binding]; other site 272631004270 ligand binding site [chemical binding]; other site 272631004271 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272631004272 substrate binding site [chemical binding]; other site 272631004273 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631004274 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272631004275 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272631004276 ABC transporter; Region: ABC_tran_2; pfam12848 272631004277 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272631004278 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631004279 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272631004280 catalytic residues [active] 272631004281 cation-transporting ATPase (pseudogene) 272631004282 similar at C-term to adenylate cyclases (pseudogene) 272631004283 probable cutinase (pseudogene) 272631004284 transposase (pseudogene) 272631004285 group II intron maturase-related protein 272631004287 cobinamide kinase (pseudogene) 272631004288 cobyric acid synthase (pseudogene) 272631004289 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 272631004290 PPE family; Region: PPE; pfam00823 272631004292 aminotransferase (pseudogene) 272631004293 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272631004294 active site 272631004295 adenylate kinase; Reviewed; Region: adk; PRK00279 272631004296 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272631004297 AMP-binding site [chemical binding]; other site 272631004298 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272631004299 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272631004300 SecY translocase; Region: SecY; pfam00344 272631004301 conserved hypothetical protein (pseudogene) 272631004302 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272631004303 primary dimer interface [polypeptide binding]; other site 272631004304 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272631004305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272631004306 Coenzyme A binding pocket [chemical binding]; other site 272631004307 xylulose kinase (pseudogene) 272631004308 similar to D-3-phosphoglycerate dehydrogenases (pseudogene) 272631004309 L-fuculose phosphate aldolase (pseudogene) 272631004310 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 272631004311 tandem repeat interface [polypeptide binding]; other site 272631004312 oligomer interface [polypeptide binding]; other site 272631004313 active site residues [active] 272631004314 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272631004315 tandem repeat interface [polypeptide binding]; other site 272631004316 oligomer interface [polypeptide binding]; other site 272631004317 active site residues [active] 272631004318 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272631004319 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272631004320 23S rRNA binding site [nucleotide binding]; other site 272631004321 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 272631004322 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272631004323 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272631004324 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272631004325 5S rRNA interface [nucleotide binding]; other site 272631004326 L27 interface [polypeptide binding]; other site 272631004327 23S rRNA interface [nucleotide binding]; other site 272631004328 L5 interface [polypeptide binding]; other site 272631004329 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272631004330 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272631004331 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272631004332 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272631004333 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272631004334 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272631004335 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272631004336 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272631004337 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272631004338 RNA binding site [nucleotide binding]; other site 272631004339 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272631004340 conserved hypothetical protein (pseudogene) 272631004341 conserved hypothetical protein (pseudogene) 272631004342 integral membrane protein (pseudogene) 272631004343 arylsulfatase (pseudogene) 272631004344 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272631004345 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272631004346 putative translocon interaction site; other site 272631004347 23S rRNA interface [nucleotide binding]; other site 272631004348 signal recognition particle (SRP54) interaction site; other site 272631004349 L23 interface [polypeptide binding]; other site 272631004350 trigger factor interaction site; other site 272631004351 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272631004352 23S rRNA interface [nucleotide binding]; other site 272631004353 5S rRNA interface [nucleotide binding]; other site 272631004354 putative antibiotic binding site [chemical binding]; other site 272631004355 L25 interface [polypeptide binding]; other site 272631004356 L27 interface [polypeptide binding]; other site 272631004357 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272631004358 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272631004359 G-X-X-G motif; other site 272631004360 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272631004361 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272631004362 putative translocon binding site; other site 272631004363 protein-rRNA interface [nucleotide binding]; other site 272631004364 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272631004365 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272631004366 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272631004367 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272631004368 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272631004369 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272631004370 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272631004371 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272631004372 PE-family protein (pseudogene) 272631004373 gmc-type oxidoreductase (pseudogene) 272631004374 glycosyltransferase (pseudogene) 272631004375 conserved hypothetical protein (pseudogene) 272631004376 L-lactate dehydrogenase (cytochrome) (pseudogene) 272631004377 coenzyme pqq synthesis protein E (pseudogene) 272631004378 hypothetical protein (pseudogene) 272631004379 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631004380 hypothetical protein (pseudogene) 272631004381 oxidoreductase (pseudogene) 272631004382 dehydrogenase, SDR family (pseudogene) 272631004383 potential membrane protein (pseudogene) 272631004384 elongation factor Tu; Reviewed; Region: PRK00049 272631004385 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272631004386 G1 box; other site 272631004387 GEF interaction site [polypeptide binding]; other site 272631004388 GTP/Mg2+ binding site [chemical binding]; other site 272631004389 Switch I region; other site 272631004390 G2 box; other site 272631004391 G3 box; other site 272631004392 Switch II region; other site 272631004393 G4 box; other site 272631004394 G5 box; other site 272631004395 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272631004396 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272631004397 Antibiotic Binding Site [chemical binding]; other site 272631004398 elongation factor G; Reviewed; Region: PRK00007 272631004399 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272631004400 G1 box; other site 272631004401 putative GEF interaction site [polypeptide binding]; other site 272631004402 GTP/Mg2+ binding site [chemical binding]; other site 272631004403 Switch I region; other site 272631004404 G2 box; other site 272631004405 G3 box; other site 272631004406 Switch II region; other site 272631004407 G4 box; other site 272631004408 G5 box; other site 272631004409 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272631004410 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272631004411 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272631004412 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272631004413 30S ribosomal protein S7; Validated; Region: PRK05302 272631004414 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272631004415 S17 interaction site [polypeptide binding]; other site 272631004416 S8 interaction site; other site 272631004417 16S rRNA interaction site [nucleotide binding]; other site 272631004418 streptomycin interaction site [chemical binding]; other site 272631004419 23S rRNA interaction site [nucleotide binding]; other site 272631004420 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272631004421 glycosyltransferase (pseudogene) 272631004422 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631004423 possible membrane protein (pseudogene) 272631004424 possible membrane protein (pseudogene) 272631004425 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631004426 hypothetical protein (pseudogene) 272631004427 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631004428 acyl-CoA dehydrogenase (aka aidB) (pseudogene) 272631004429 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 272631004430 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272631004431 AP (apurinic/apyrimidinic) site pocket; other site 272631004432 DNA interaction; other site 272631004433 Metal-binding active site; metal-binding site 272631004434 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272631004435 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272631004436 beta and beta' interface [polypeptide binding]; other site 272631004437 beta' and sigma factor interface [polypeptide binding]; other site 272631004438 Zn-binding [ion binding]; other site 272631004439 active site region [active] 272631004440 catalytic site [active] 272631004441 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272631004442 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272631004443 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272631004444 G-loop; other site 272631004445 DNA binding site [nucleotide binding] 272631004446 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272631004447 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272631004448 RPB12 interaction site [polypeptide binding]; other site 272631004449 RPB1 interaction site [polypeptide binding]; other site 272631004450 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272631004451 RPB10 interaction site [polypeptide binding]; other site 272631004452 RPB11 interaction site [polypeptide binding]; other site 272631004453 RPB3 interaction site [polypeptide binding]; other site 272631004454 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272631004455 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 272631004456 Walker A/P-loop; other site 272631004457 ATP binding site [chemical binding]; other site 272631004458 Q-loop/lid; other site 272631004459 ABC transporter signature motif; other site 272631004460 Walker B; other site 272631004461 D-loop; other site 272631004462 H-loop/switch region; other site 272631004463 dioxygenase (pseudogene) 272631004464 transcriptional regulator (pseudogene) 272631004465 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272631004466 core dimer interface [polypeptide binding]; other site 272631004467 peripheral dimer interface [polypeptide binding]; other site 272631004468 L10 interface [polypeptide binding]; other site 272631004469 L11 interface [polypeptide binding]; other site 272631004470 putative EF-Tu interaction site [polypeptide binding]; other site 272631004471 putative EF-G interaction site [polypeptide binding]; other site 272631004472 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272631004473 23S rRNA interface [nucleotide binding]; other site 272631004474 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272631004475 transcriptional regulator (ROK family) (pseudogene) 272631004476 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272631004477 active site 272631004478 ATP binding site [chemical binding]; other site 272631004479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272631004480 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272631004481 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272631004482 TAP-like protein; Region: Abhydrolase_4; pfam08386 272631004483 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272631004484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631004485 S-adenosylmethionine binding site [chemical binding]; other site 272631004486 methyl mycolic acid synthase 2 (pseudogene) 272631004487 methyl mycolic acid synthase 3 (pseudogene) 272631004488 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272631004489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631004490 S-adenosylmethionine binding site [chemical binding]; other site 272631004491 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272631004492 mRNA/rRNA interface [nucleotide binding]; other site 272631004493 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272631004494 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272631004495 23S rRNA interface [nucleotide binding]; other site 272631004496 L7/L12 interface [polypeptide binding]; other site 272631004497 putative thiostrepton binding site; other site 272631004498 L25 interface [polypeptide binding]; other site 272631004499 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272631004500 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272631004501 putative homodimer interface [polypeptide binding]; other site 272631004502 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272631004503 heterodimer interface [polypeptide binding]; other site 272631004504 homodimer interface [polypeptide binding]; other site 272631004505 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 272631004506 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 272631004507 active site 272631004508 catalytic site [active] 272631004509 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 272631004510 active site 272631004511 catalytic site [active] 272631004512 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 272631004513 active site 272631004514 catalytic site [active] 272631004515 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272631004516 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 272631004517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272631004518 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631004519 equivalent to MKU20446_1 MK35 (pseudogene) 272631004520 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 272631004521 hypothetical protein (pseudogene) 272631004522 conserved hypothetical protein (pseudogene) 272631004523 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 272631004524 active site clefts [active] 272631004525 zinc binding site [ion binding]; other site 272631004526 dimer interface [polypeptide binding]; other site 272631004527 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272631004528 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272631004529 minor groove reading motif; other site 272631004530 helix-hairpin-helix signature motif; other site 272631004531 substrate binding pocket [chemical binding]; other site 272631004532 active site 272631004533 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272631004534 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272631004535 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272631004536 catalytic site [active] 272631004537 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 272631004538 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 272631004539 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272631004540 conserved hypothetical protein (pseudogene) 272631004541 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 272631004542 E-class dimer interface [polypeptide binding]; other site 272631004543 P-class dimer interface [polypeptide binding]; other site 272631004544 active site 272631004545 Cu2+ binding site [ion binding]; other site 272631004546 Zn2+ binding site [ion binding]; other site 272631004547 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 272631004548 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 272631004549 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272631004550 active site 272631004551 catalytic residues [active] 272631004552 metal binding site [ion binding]; metal-binding site 272631004553 hypothetical protein (pseudogene) 272631004554 exodeoxyribonuclease III (pseudogene) 272631004555 cation-transporting (pseudogene) 272631004556 hypothetical protein (pseudogene) 272631004557 PPE-family protein (pseudogene) 272631004558 GTP-binding protein YchF; Reviewed; Region: PRK09601 272631004559 YchF GTPase; Region: YchF; cd01900 272631004560 G1 box; other site 272631004561 GTP/Mg2+ binding site [chemical binding]; other site 272631004562 Switch I region; other site 272631004563 G2 box; other site 272631004564 Switch II region; other site 272631004565 G3 box; other site 272631004566 G4 box; other site 272631004567 G5 box; other site 272631004568 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272631004569 hypothetical protein; Provisional; Region: PHA02666 272631004570 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 272631004571 Fe-S cluster binding site [ion binding]; other site 272631004572 substrate binding site [chemical binding]; other site 272631004573 catalytic site [active] 272631004574 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 272631004575 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272631004576 generic binding surface II; other site 272631004577 generic binding surface I; other site 272631004578 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 272631004579 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272631004580 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 272631004581 putative NAD(P) binding site [chemical binding]; other site 272631004582 active site 272631004583 putative substrate binding site [chemical binding]; other site 272631004584 conserved hypothetical protein (pseudogene) 272631004585 possible IS1081 transposase (pseudogene) 272631004586 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 272631004587 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272631004588 putative active site [active] 272631004589 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272631004590 Class II fumarases; Region: Fumarase_classII; cd01362 272631004591 active site 272631004592 tetramer interface [polypeptide binding]; other site 272631004593 probable transmembrane protein (pseudogene) 272631004594 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272631004595 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 272631004596 NodB motif; other site 272631004597 active site 272631004598 catalytic site [active] 272631004599 metal binding site [ion binding]; metal-binding site 272631004600 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 272631004601 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 272631004602 putative active site [active] 272631004603 PhoH-like protein; Region: PhoH; pfam02562 272631004604 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 272631004605 dinuclear metal binding motif [ion binding]; other site 272631004606 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272631004607 dimer interface [polypeptide binding]; other site 272631004608 active site 272631004609 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272631004610 folate binding site [chemical binding]; other site 272631004611 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272631004612 ATP-binding site [chemical binding]; other site 272631004613 CoA-binding site [chemical binding]; other site 272631004614 Mg2+-binding site [ion binding]; other site 272631004615 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 272631004616 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272631004617 dimerization interface 3.5A [polypeptide binding]; other site 272631004618 active site 272631004619 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272631004620 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272631004621 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272631004622 alphaNTD - beta interaction site [polypeptide binding]; other site 272631004623 alphaNTD homodimer interface [polypeptide binding]; other site 272631004624 alphaNTD - beta' interaction site [polypeptide binding]; other site 272631004625 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272631004626 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272631004627 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272631004628 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272631004629 RNA binding surface [nucleotide binding]; other site 272631004630 30S ribosomal protein S11; Validated; Region: PRK05309 272631004631 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272631004632 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 272631004633 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272631004634 rRNA binding site [nucleotide binding]; other site 272631004635 predicted 30S ribosome binding site; other site 272631004636 probable neuraminidase (pseudogene) 272631004637 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272631004638 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272631004639 NAD binding site [chemical binding]; other site 272631004640 substrate binding site [chemical binding]; other site 272631004641 homodimer interface [polypeptide binding]; other site 272631004642 active site 272631004643 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272631004644 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 272631004645 PPE family protein (pseudogene) 272631004646 PE family protein (pseudogene) 272631004648 group II intron maturase-related protein 272631004650 glycosyl hydrolase (pseudogene) 272631004651 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272631004652 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272631004653 probable oxidoreductase (pseudogene) 272631004654 membrane protein (pseudogene) 272631004655 probable epoxide hydrolase (pseudogene) 272631004656 acyl-CoA synthase (pseudogene) 272631004657 hypothetical protein (pseudogene) 272631004658 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 272631004659 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 272631004660 putative hydrophobic ligand binding site [chemical binding]; other site 272631004661 protein interface [polypeptide binding]; other site 272631004662 gate; other site 272631004663 possible oxidoreductase (pseudogene) 272631004664 isocitrate lyase; Region: PLN02892 272631004665 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272631004666 tetramer interface [polypeptide binding]; other site 272631004667 active site 272631004668 Mg2+/Mn2+ binding site [ion binding]; other site 272631004669 ECF subfamily sigma subunit (pseudogene) 272631004670 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272631004671 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272631004672 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272631004673 Predicted integral membrane protein [Function unknown]; Region: COG5660 272631004674 Putative zinc-finger; Region: zf-HC2; pfam13490 272631004675 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 272631004676 PPE family; Region: PPE; pfam00823 272631004677 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 272631004678 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 272631004679 FcoT-like thioesterase domain; Region: FcoT; pfam10862 272631004680 acyl-CoA synthetase; Validated; Region: PRK05857 272631004681 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 272631004682 acyl-activating enzyme (AAE) consensus motif; other site 272631004683 AMP binding site [chemical binding]; other site 272631004684 active site 272631004685 CoA binding site [chemical binding]; other site 272631004686 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272631004687 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 272631004688 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631004689 acyl-activating enzyme (AAE) consensus motif; other site 272631004690 AMP binding site [chemical binding]; other site 272631004691 active site 272631004692 CoA binding site [chemical binding]; other site 272631004693 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272631004694 thioester reductase domain; Region: Thioester-redct; TIGR01746 272631004695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631004696 NAD(P) binding site [chemical binding]; other site 272631004697 active site 272631004698 Predicted membrane protein [Function unknown]; Region: COG3336 272631004699 carboxyvinyl-carboxyphosphonate phosphorylmutase (pseudogene) 272631004700 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272631004701 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272631004702 metal-binding site [ion binding] 272631004703 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272631004704 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272631004705 hypothetical protein (pseudogene) 272631004706 3-hydroxyacyl-CoA dehydrogenase (pseudogene) 272631004707 probable ketoacyl reductase (pseudogene) 272631004708 hydrolase (pseudogene) 272631004709 conserved hypothetical protein (pseudogene) 272631004710 conserved hypothetical protein (pseudogene) 272631004711 hypothetical protein (pseudogene) 272631004712 ferric uptake regulatory protein (pseudogene) 272631004713 catalase-peroxidase (pseudogene) 272631004714 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631004715 FAD dependent oxidoreductase; Region: DAO; pfam01266 272631004716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631004717 Predicted membrane protein [Function unknown]; Region: COG1950 272631004718 probable sialic acid transporter (pseudogene) 272631004719 competence damage-inducible protein A; Provisional; Region: PRK00549 272631004720 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272631004721 putative MPT binding site; other site 272631004722 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 272631004723 probable esterase (pseudogene) 272631004724 lipoprotein (pseudogene) 272631004725 hypothetical protein (pseudogene) 272631004726 conserved hypothetical protein (pseudogene) 272631004727 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 272631004728 some similarity to dioxygenases (pseudogene) 272631004729 cytochrome p450 (pseudogene) 272631004730 alcohol dehydrogenase (pseudogene) 272631004731 hypothetical protein (pseudogene) 272631004732 hypothetical protein (pseudogene) 272631004733 Predicted esterase [General function prediction only]; Region: COG0627 272631004734 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 272631004735 hypothetical protein (pseudogene) 272631004736 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 272631004737 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 272631004738 hydrophobic ligand binding site; other site 272631004739 lipoprotein (pseudogene) 272631004740 Similar to 6-deoxyerythronolide beta hydroxylase (pseudogene) 272631004741 methyltransferase (pseudogene) 272631004742 conserved hypothetical protein (pseudogene) 272631004743 probable glutamine synthase (pseudogene) 272631004744 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 272631004745 Ferritin-like domain; Region: Ferritin; pfam00210 272631004746 heme binding site [chemical binding]; other site 272631004747 ferroxidase pore; other site 272631004748 ferroxidase diiron center [ion binding]; other site 272631004749 conserved hypothetical protein (pseudogene) 272631004750 hypothetical protein (pseudogene) 272631004751 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 272631004752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272631004753 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 272631004754 dimerization interface [polypeptide binding]; other site 272631004755 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272631004756 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272631004757 dimer interface [polypeptide binding]; other site 272631004758 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272631004759 catalytic triad [active] 272631004760 peroxidatic and resolving cysteines [active] 272631004761 member of AhpC/TSA family (pseudogene) 272631004762 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272631004763 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 272631004764 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 272631004765 active site 272631004766 substrate binding site [chemical binding]; other site 272631004767 FMN binding site [chemical binding]; other site 272631004768 putative catalytic residues [active] 272631004769 conserved hypothetical protein (pseudogene) 272631004770 Domain of unknown function (DUF385); Region: DUF385; cl04387 272631004771 hypothetical protein (pseudogene) 272631004772 probable reductase (like rhodocoxin reductase) (pseudogene) 272631004773 conserved hypothetical protein (pseudogene) 272631004774 probable membrane protein (pseudogene) 272631004775 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 272631004776 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 272631004777 putative NAD(P) binding site [chemical binding]; other site 272631004778 putative substrate binding site [chemical binding]; other site 272631004779 catalytic Zn binding site [ion binding]; other site 272631004780 structural Zn binding site [ion binding]; other site 272631004781 Predicted membrane protein [Function unknown]; Region: COG2261 272631004782 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 272631004783 molybdate uptake ABC-transporter (pseudogene) 272631004784 transport system permease, molybdate uptake (pseudogene) 272631004785 molybdate binding protein (pseudogene) 272631004786 classical (c) SDRs; Region: SDR_c; cd05233 272631004787 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 272631004788 NAD(P) binding site [chemical binding]; other site 272631004789 active site 272631004790 probable monooxygenase (pseudogene) 272631004791 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272631004792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272631004793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272631004794 conserved hypothetical protein (pseudogene) 272631004795 Predicted transcriptional regulator [Transcription]; Region: COG3682 272631004796 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272631004797 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272631004798 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 272631004799 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272631004800 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 272631004801 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272631004802 active site 272631004803 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 272631004804 possible membrane protein (pseudogene) 272631004805 possible membrane protein (pseudogene) 272631004806 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 272631004807 active site 272631004808 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272631004809 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 272631004810 metal ion-dependent adhesion site (MIDAS); other site 272631004811 similar to 1,3,4,6-tetrachloro-1,4-cyclohexadien (pseudogene) 272631004812 glycine dehydrogenase; Provisional; Region: PRK05367 272631004813 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272631004814 tetramer interface [polypeptide binding]; other site 272631004815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631004816 catalytic residue [active] 272631004817 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272631004818 tetramer interface [polypeptide binding]; other site 272631004819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631004820 catalytic residue [active] 272631004821 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 272631004822 DNA binding residues [nucleotide binding] 272631004823 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272631004824 putative dimer interface [polypeptide binding]; other site 272631004825 Bifunctional nuclease; Region: DNase-RNase; pfam02577 272631004826 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272631004827 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 272631004828 DNA binding residues [nucleotide binding] 272631004829 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272631004830 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272631004831 phosphopeptide binding site; other site 272631004832 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272631004833 lipoyl attachment site [posttranslational modification]; other site 272631004834 hypothetical protein (pseudogene) 272631004835 small basic protein similar SBP_BACSU (pseudogene) 272631004836 conserved hypothetical protein (pseudogene) 272631004837 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 272631004838 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 272631004839 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 272631004840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272631004841 nucleotide binding region [chemical binding]; other site 272631004842 ATP-binding site [chemical binding]; other site 272631004843 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272631004844 hypothetical protein; Provisional; Region: PRK05858 272631004845 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272631004846 PYR/PP interface [polypeptide binding]; other site 272631004847 dimer interface [polypeptide binding]; other site 272631004848 TPP binding site [chemical binding]; other site 272631004849 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272631004850 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 272631004851 TPP-binding site; other site 272631004852 dimer interface [polypeptide binding]; other site 272631004853 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 272631004854 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 272631004855 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 272631004857 group II intron maturase-related protein 272631004859 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272631004860 probable dehydrase (pseudogene) 272631004861 conserved hypothetical protein (pseudogene) 272631004862 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 272631004863 ATP binding site [chemical binding]; other site 272631004864 substrate binding site [chemical binding]; other site 272631004865 conserved hypothetical protein (pseudogene) 272631004866 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272631004867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631004868 dimer interface [polypeptide binding]; other site 272631004869 conserved gate region; other site 272631004870 putative PBP binding loops; other site 272631004871 ABC-ATPase subunit interface; other site 272631004872 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272631004873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272631004874 dimer interface [polypeptide binding]; other site 272631004875 conserved gate region; other site 272631004876 putative PBP binding loops; other site 272631004877 ABC-ATPase subunit interface; other site 272631004878 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272631004879 short-chain alcohol dehydrogenase family (pseudogene) 272631004880 conserved hypothetical protein (pseudogene) 272631004881 manganese transport protein MntH; Reviewed; Region: PRK00701 272631004882 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272631004883 ribonucleotide reductase, class II (pseudogene) 272631004884 conserved hypothetical protein (pseudogene) 272631004885 conserved hypothetical protein (pseudogene) 272631004886 esterase (pseudogene) 272631004887 conserved hypothetical protein (pseudogene) 272631004888 hypothetical protein (pseudogene) 272631004889 conserved hypothetical protein (pseudogene) 272631004890 conserved hypothetical protein (pseudogene) 272631004891 conserved hypothetical protein (pseudogene) 272631004892 conserved hypothetical protein (pseudogene) 272631004893 lipid transfer protein (pseudogene) 272631004894 probable dioxygenase (pseudogene) 272631004895 conserved hypothetical protein (pseudogene) 272631004896 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 272631004897 hydrophobic ligand binding site; other site 272631004898 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 272631004899 probable cation transport ATPase (pseudogene) 272631004900 probable penicillin binding protein (pseudogene) 272631004901 probable membrane protein (pseudogene) 272631004902 enoyl-CoA hydratase; Provisional; Region: PRK07854 272631004903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631004904 substrate binding site [chemical binding]; other site 272631004905 oxyanion hole (OAH) forming residues; other site 272631004906 trimer interface [polypeptide binding]; other site 272631004907 acetyl/propionyl CoA carboxylase [beta] subunit (pseudogene) 272631004908 conserved hypothetical protein (pseudogene) 272631004909 dehydrogenase (pseudogene) 272631004910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272631004911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272631004912 active site 272631004913 phosphorylation site [posttranslational modification] 272631004914 intermolecular recognition site; other site 272631004915 dimerization interface [polypeptide binding]; other site 272631004916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272631004917 DNA binding site [nucleotide binding] 272631004918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272631004919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272631004920 dimerization interface [polypeptide binding]; other site 272631004921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272631004922 dimer interface [polypeptide binding]; other site 272631004923 phosphorylation site [posttranslational modification] 272631004924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272631004925 ATP binding site [chemical binding]; other site 272631004926 Mg2+ binding site [ion binding]; other site 272631004927 G-X-G motif; other site 272631004928 conserved hypothetical protein (pseudogene) 272631004929 member of OmpA family (pseudogene) 272631004930 possible oxidoreductase (pseudogene) 272631004931 PPE-family protein (pseudogene) 272631004932 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 272631004933 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272631004934 dimer interface [polypeptide binding]; other site 272631004935 active site 272631004936 citrylCoA binding site [chemical binding]; other site 272631004937 NADH binding [chemical binding]; other site 272631004938 cationic pore residues; other site 272631004939 oxalacetate/citrate binding site [chemical binding]; other site 272631004940 coenzyme A binding site [chemical binding]; other site 272631004941 catalytic triad [active] 272631004942 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 272631004943 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272631004944 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 272631004945 citrate synthase 2 (pseudogene) 272631004946 hypothetical protein (pseudogene) 272631004947 Ferredoxin [Energy production and conversion]; Region: COG1146 272631004948 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272631004949 4Fe-4S binding domain; Region: Fer4; pfam00037 272631004950 ferredoxin-NADP+ reductase; Region: PLN02852 272631004951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631004952 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 272631004953 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272631004954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272631004955 catalytic residue [active] 272631004956 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 272631004957 unknown hydrophobic protein (pseudogene) 272631004958 possible rRNA methyltransferase (pseudogene) 272631004959 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272631004960 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272631004961 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 272631004962 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 272631004963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272631004964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272631004965 putative substrate translocation pore; other site 272631004966 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 272631004967 transport of D-alanine, D-serine and glycine (pseudogene) 272631004968 acyl-CoA dehydrogenase (pseudogene) 272631004969 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272631004970 DNA-binding site [nucleotide binding]; DNA binding site 272631004971 RNA-binding motif; other site 272631004972 unknown hydrophobic protein (pseudogene) 272631004973 molybdenum cofactor biosynthesis, protein A (pseudogene) 272631004974 molybdopterin converting factor subunit 1 (pseudogene) 272631004975 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 272631004976 molybdopterin-converting factor subunit 2 (pseudogene) 272631004977 molybdopterin biosynthesis (pseudogene) 272631004978 molybdenum cofactor biosynthesis, protein C (pseudogene) 272631004979 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 272631004980 WYL domain; Region: WYL; pfam13280 272631004981 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 272631004982 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 272631004983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272631004984 ATP binding site [chemical binding]; other site 272631004985 putative Mg++ binding site [ion binding]; other site 272631004986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272631004987 nucleotide binding region [chemical binding]; other site 272631004988 ATP-binding site [chemical binding]; other site 272631004989 possible cytochrome P450 (pseudogene) 272631004990 probable oxidoreductase (pseudogene) 272631004991 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 272631004992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631004993 substrate binding site [chemical binding]; other site 272631004994 oxyanion hole (OAH) forming residues; other site 272631004995 trimer interface [polypeptide binding]; other site 272631004996 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272631004997 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272631004998 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 272631004999 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272631005000 dimer interface [polypeptide binding]; other site 272631005001 active site 272631005002 possible aminotransferase (pseudogene) 272631005003 conserved hypothetical protein (pseudogene) 272631005004 fatty acyl-CoA racemase (pseudogene) 272631005005 conserved hypothetical protein (pseudogene) 272631005006 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 272631005007 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 272631005008 dimer interface [polypeptide binding]; other site 272631005009 PYR/PP interface [polypeptide binding]; other site 272631005010 TPP binding site [chemical binding]; other site 272631005011 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272631005012 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 272631005013 TPP-binding site [chemical binding]; other site 272631005014 dimer interface [polypeptide binding]; other site 272631005015 acyl-CoA synthase (pseudogene) 272631005016 acyl-CoA synthase (pseudogene) 272631005017 similar to several L-ascorbate oxidases (pseudogene) 272631005018 possible oxidoredutase (pseudogene) 272631005019 cytidine deaminase, homotetrameric; Region: cyt_deam_tetra; TIGR01354 272631005020 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272631005021 active site 272631005022 catalytic motif [active] 272631005023 Zn binding site [ion binding]; other site 272631005024 possible sugar transporter (pseudogene) 272631005025 uridine phosphorylase; Region: euk_UDPppase; TIGR01719 272631005026 transcriptional regulator (pseudogene) 272631005027 conserved hypothetical protein (pseudogene) 272631005028 conserved hypothetical protein (pseudogene) 272631005029 transcriptional regulator (ArsR family) (pseudogene) 272631005030 conserved hypothetical protein (pseudogene) 272631005031 conserved hypothetical protein (pseudogene) 272631005032 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 272631005033 homodimer interface [polypeptide binding]; other site 272631005034 putative substrate binding pocket [chemical binding]; other site 272631005035 diiron center [ion binding]; other site 272631005036 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272631005037 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272631005038 FMN binding site [chemical binding]; other site 272631005039 active site 272631005040 catalytic residues [active] 272631005041 substrate binding site [chemical binding]; other site 272631005042 conserved hypothetical protein (pseudogene) 272631005043 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272631005044 PhoU domain; Region: PhoU; pfam01895 272631005045 PhoU domain; Region: PhoU; pfam01895 272631005046 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 272631005047 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272631005048 Walker A/P-loop; other site 272631005049 ATP binding site [chemical binding]; other site 272631005050 Q-loop/lid; other site 272631005051 ABC transporter signature motif; other site 272631005052 Walker B; other site 272631005053 D-loop; other site 272631005054 H-loop/switch region; other site 272631005055 PstA component of phosphate uptake (pseudogene) 272631005056 membrane-bound component of phosphate transport (pseudogene) 272631005057 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272631005058 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 272631005059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272631005060 Coenzyme A binding pocket [chemical binding]; other site 272631005061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272631005062 Coenzyme A binding pocket [chemical binding]; other site 272631005063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272631005064 two-component response regulator (pseudogene) 272631005065 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 272631005066 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272631005067 catalytic residues [active] 272631005068 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 272631005069 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272631005070 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272631005071 active site residue [active] 272631005072 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272631005073 active site residue [active] 272631005074 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 272631005075 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 272631005076 heme-binding site [chemical binding]; other site 272631005077 aminodeoxychorismate lyase (pseudogene) 272631005078 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 272631005079 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 272631005080 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272631005081 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272631005082 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 272631005083 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272631005084 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272631005085 dimerization interface [polypeptide binding]; other site 272631005086 putative ATP binding site [chemical binding]; other site 272631005087 amidophosphoribosyltransferase; Provisional; Region: PRK07847 272631005088 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272631005089 active site 272631005090 tetramer interface [polypeptide binding]; other site 272631005091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272631005092 active site 272631005093 cell invasion protein (pseudogene) 272631005094 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272631005095 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 272631005096 active site 272631005097 metal binding site [ion binding]; metal-binding site 272631005098 hexamer interface [polypeptide binding]; other site 272631005099 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272631005100 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272631005101 dimerization interface [polypeptide binding]; other site 272631005102 ATP binding site [chemical binding]; other site 272631005103 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272631005104 dimerization interface [polypeptide binding]; other site 272631005105 ATP binding site [chemical binding]; other site 272631005106 acetyltransferase (pseudogene) 272631005107 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 272631005108 active site 272631005109 metal binding site [ion binding]; metal-binding site 272631005110 conserved hypothetical protein (pseudogene) 272631005111 probable penicillin binding protein (pseudogene) 272631005112 dihydrolipoamide dehydrogenase (pseudogene) 272631005113 hypothetical protein (pseudogene) 272631005114 hypothetical protein (pseudogene) 272631005115 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272631005116 putative active site [active] 272631005117 catalytic triad [active] 272631005118 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 272631005119 hypothetical protein (pseudogene) 272631005120 conserved hypothetical protein (pseudogene) 272631005121 dehydrogenases (pseudogene) 272631005122 conserved hypothetical protein (pseudogene) 272631005123 multidrug resistance protein (pseudogene) 272631005124 transcriptional regulator, tetr family (pseudogene) 272631005125 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 272631005126 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272631005127 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 272631005128 ATP binding site [chemical binding]; other site 272631005129 active site 272631005130 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 272631005131 substrate binding site [chemical binding]; other site 272631005132 similar linalool 8-monooxygenase, cytochrome p-450 (pseudogene) 272631005133 adenylosuccinate lyase; Region: purB; TIGR00928 272631005134 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 272631005135 tetramer interface [polypeptide binding]; other site 272631005136 conserved hypothetical protein (pseudogene) 272631005137 conserved hypothetical protein (pseudogene) 272631005138 conserved hypothetical protein (pseudogene) 272631005139 [gamma]-glutamyl transpeptidase (pseudogene) 272631005140 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272631005141 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272631005142 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272631005143 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272631005144 REP13E12-family protein (pseudogene) 272631005145 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 272631005146 nucleotide binding site/active site [active] 272631005147 HIT family signature motif; other site 272631005148 catalytic residue [active] 272631005149 sensor histidine kinase (pseudogene) 272631005150 two-component response regulator (pseudogene) 272631005151 hypothetical protein (pseudogene) 272631005152 PE_PGRS-family protein (pseudogene) 272631005153 PPE-family protein (pseudogene) 272631005154 sarcosine oxidase (pseudogene) 272631005155 unknown membrane protein (pseudogene) 272631005156 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272631005157 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 272631005158 probable fatty-acyl CoA reductase (pseudogene) 272631005159 short-chain alcohol dehydrogenase family (pseudogene) 272631005160 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631005161 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 272631005162 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 272631005163 active site 272631005164 homotetramer interface [polypeptide binding]; other site 272631005165 hypothetical protein (pseudogene) 272631005166 unknown membrane protein (pseudogene) 272631005167 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 272631005168 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631005169 acyl-activating enzyme (AAE) consensus motif; other site 272631005170 AMP binding site [chemical binding]; other site 272631005171 active site 272631005172 CoA binding site [chemical binding]; other site 272631005173 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 272631005174 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272631005175 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272631005176 active site 272631005177 oxidoreductase (pseudogene) 272631005178 Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447 272631005179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631005180 substrate binding site [chemical binding]; other site 272631005181 oxyanion hole (OAH) forming residues; other site 272631005182 trimer interface [polypeptide binding]; other site 272631005183 acyl-CoA synthase (pseudogene) 272631005184 transcriptional regulator (pseudogene) 272631005185 O-succinylbenzoate synthase; Provisional; Region: PRK02901 272631005186 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 272631005187 active site 272631005188 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272631005189 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272631005190 TAP-like protein; Region: Abhydrolase_4; pfam08386 272631005191 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 272631005192 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 272631005193 dimer interface [polypeptide binding]; other site 272631005194 tetramer interface [polypeptide binding]; other site 272631005195 PYR/PP interface [polypeptide binding]; other site 272631005196 TPP binding site [chemical binding]; other site 272631005197 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 272631005198 TPP-binding site; other site 272631005199 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 272631005200 conserved hypothetical protein (pseudogene) 272631005201 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272631005202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631005203 S-adenosylmethionine binding site [chemical binding]; other site 272631005204 Protein of unknown function (DUF732); Region: DUF732; pfam05305 272631005205 methyl transferase (pseudogene) 272631005206 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 272631005207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631005208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631005209 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272631005210 substrate binding pocket [chemical binding]; other site 272631005211 chain length determination region; other site 272631005212 substrate-Mg2+ binding site; other site 272631005213 catalytic residues [active] 272631005214 aspartate-rich region 1; other site 272631005215 active site lid residues [active] 272631005216 aspartate-rich region 2; other site 272631005217 heat shock protein HtpX; Provisional; Region: PRK03072 272631005218 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272631005219 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272631005220 Sulfate transporter family; Region: Sulfate_transp; cl19250 272631005221 glycerol-3-phosphate dehydrogenase (pseudogene) 272631005222 Probable monooxygenasemonoxygenase (pseudogene) 272631005223 conserved hypothetical protein (pseudogene) 272631005224 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272631005225 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 272631005226 probable membrane protein (pseudogene) 272631005227 transcriptional regulator (LysR family) (pseudogene) 272631005228 possible oxidoreductase (pseudogene) 272631005229 probable ABC-transporter (pseudogene) 272631005230 probable peptide transport system permease (pseudogene) 272631005231 probable peptide transport system permease (pseudogene) 272631005232 peptide transport system peptide-binding protein (pseudogene) 272631005233 acetyl-CoA synthase (pseudogene) 272631005234 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272631005235 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 272631005236 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272631005237 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272631005238 Colicin V production protein; Region: Colicin_V; pfam02674 272631005239 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272631005240 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 272631005241 putative active site [active] 272631005242 putative CoA binding site [chemical binding]; other site 272631005243 nudix motif; other site 272631005244 metal binding site [ion binding]; metal-binding site 272631005245 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272631005246 catalytic residues [active] 272631005247 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272631005248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272631005249 minor groove reading motif; other site 272631005250 helix-hairpin-helix signature motif; other site 272631005251 substrate binding pocket [chemical binding]; other site 272631005252 active site 272631005253 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272631005254 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272631005255 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272631005256 ligand binding site [chemical binding]; other site 272631005257 flexible hinge region; other site 272631005258 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272631005259 putative switch regulator; other site 272631005260 non-specific DNA interactions [nucleotide binding]; other site 272631005261 DNA binding site [nucleotide binding] 272631005262 sequence specific DNA binding site [nucleotide binding]; other site 272631005263 putative cAMP binding site [chemical binding]; other site 272631005264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272631005265 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 272631005266 homotrimer interaction site [polypeptide binding]; other site 272631005267 putative active site [active] 272631005268 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 272631005269 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272631005270 P loop; other site 272631005271 Nucleotide binding site [chemical binding]; other site 272631005272 DTAP/Switch II; other site 272631005273 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 272631005274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272631005275 Transcription factor WhiB; Region: Whib; pfam02467 272631005276 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272631005277 Transglycosylase; Region: Transgly; pfam00912 272631005278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272631005279 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272631005280 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272631005281 putative active site [active] 272631005282 putative metal binding site [ion binding]; other site 272631005283 Probable lyase, cysteine metabolism (pseudogene) 272631005284 conserved hypothetical protein (pseudogene) 272631005285 Predicted membrane protein/domain [Function unknown]; Region: COG1714 272631005286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272631005287 dimerization interface [polypeptide binding]; other site 272631005288 putative DNA binding site [nucleotide binding]; other site 272631005289 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272631005290 putative Zn2+ binding site [ion binding]; other site 272631005291 glycerol kinase; Provisional; Region: glpK; PRK00047 272631005292 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272631005293 nucleotide binding site [chemical binding]; other site 272631005294 hypothetical protein (pseudogene) 272631005295 Probable methyltransferase (pseudogene) 272631005296 conserved hypothetical protein (pseudogene) 272631005297 conserved hypothetical protein (pseudogene) 272631005298 possible [gamma]-glutamylcysteine synthase (pseudogene) 272631005299 PknH-like extracellular domain; Region: PknH_C; pfam14032 272631005300 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 272631005301 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272631005302 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272631005303 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272631005304 aspartate kinase; Reviewed; Region: PRK06635 272631005305 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 272631005306 putative nucleotide binding site [chemical binding]; other site 272631005307 putative catalytic residues [active] 272631005308 putative Mg ion binding site [ion binding]; other site 272631005309 putative aspartate binding site [chemical binding]; other site 272631005310 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 272631005311 putative allosteric regulatory site; other site 272631005312 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 272631005313 2-isopropylmalate synthase; Validated; Region: PRK03739 272631005314 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 272631005315 active site 272631005316 catalytic residues [active] 272631005317 metal binding site [ion binding]; metal-binding site 272631005318 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272631005319 DNA polymerase III [epsilon] chain (pseudogene) 272631005320 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 272631005321 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272631005322 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 272631005323 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272631005324 catalytic triad [active] 272631005325 conserved hypothetical protein (pseudogene) 272631005326 recombination protein RecR; Reviewed; Region: recR; PRK00076 272631005327 Helix-hairpin-helix motif; Region: HHH; pfam00633 272631005328 RecR protein; Region: RecR; pfam02132 272631005329 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272631005330 putative active site [active] 272631005331 putative metal-binding site [ion binding]; other site 272631005332 tetramer interface [polypeptide binding]; other site 272631005333 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 272631005334 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272631005335 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272631005336 active site 272631005337 metal binding site [ion binding]; metal-binding site 272631005338 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 272631005339 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272631005340 FAD binding domain; Region: FAD_binding_4; cl19922 272631005341 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272631005342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631005343 S-adenosylmethionine binding site [chemical binding]; other site 272631005344 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 272631005345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631005346 Walker A motif; other site 272631005347 ATP binding site [chemical binding]; other site 272631005348 Walker B motif; other site 272631005349 arginine finger; other site 272631005350 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272631005351 Immediate early response protein (IER); Region: IER; pfam05760 272631005352 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272631005353 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272631005354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272631005355 catalytic residue [active] 272631005356 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 272631005357 probable esterase (pseudogene) 272631005358 probable cutinase precursor (pseudogene) 272631005359 possible sugar transporter (pseudogene) 272631005360 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272631005361 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 272631005362 cyclase homology domain; Region: CHD; cd07302 272631005363 nucleotidyl binding site; other site 272631005364 metal binding site [ion binding]; metal-binding site 272631005365 dimer interface [polypeptide binding]; other site 272631005366 Predicted ATPase [General function prediction only]; Region: COG3899 272631005367 AAA ATPase domain; Region: AAA_16; pfam13191 272631005368 conserved hypothetical protein (pseudogene) 272631005369 L-asparaginase (pseudogene) 272631005370 probable sugar transporter (pseudogene) 272631005371 transcriptional regulator (Crp/Fnr family) (pseudogene) 272631005372 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 272631005373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631005374 S-adenosylmethionine binding site [chemical binding]; other site 272631005375 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 272631005376 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 272631005377 homodimer interface [polypeptide binding]; other site 272631005378 active site 272631005379 TDP-binding site; other site 272631005380 acceptor substrate-binding pocket; other site 272631005381 acyltransferase PapA5; Provisional; Region: PRK09294 272631005382 Condensation domain; Region: Condensation; cl19241 272631005383 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272631005384 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272631005385 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272631005386 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272631005387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272631005388 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 272631005389 Walker A/P-loop; other site 272631005390 ATP binding site [chemical binding]; other site 272631005391 Q-loop/lid; other site 272631005392 ABC transporter signature motif; other site 272631005393 Walker B; other site 272631005394 D-loop; other site 272631005395 H-loop/switch region; other site 272631005396 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631005397 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631005398 active site 272631005399 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272631005400 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272631005401 Condensation domain; Region: Condensation; cl19241 272631005402 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 272631005403 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631005404 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631005405 active site 272631005406 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272631005407 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 272631005408 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 272631005409 putative NADP binding site [chemical binding]; other site 272631005410 short chain dehydrogenase; Region: adh_short; pfam00106 272631005411 active site 272631005412 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272631005413 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631005414 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631005415 active site 272631005416 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 272631005417 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 272631005418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631005419 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 272631005420 Enoylreductase; Region: PKS_ER; smart00829 272631005421 NAD(P) binding site [chemical binding]; other site 272631005422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631005423 short chain dehydrogenase; Region: adh_short; pfam00106 272631005424 NAD(P) binding site [chemical binding]; other site 272631005425 active site 272631005426 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272631005427 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631005428 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631005429 active site 272631005430 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 272631005431 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 272631005432 short chain dehydrogenase; Region: adh_short; pfam00106 272631005433 NADP binding site [chemical binding]; other site 272631005434 active site 272631005435 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272631005436 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272631005437 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272631005438 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272631005439 active site 272631005440 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 272631005441 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 272631005442 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 272631005443 short chain dehydrogenase; Region: adh_short; pfam00106 272631005444 NADP binding site [chemical binding]; other site 272631005445 active site 272631005446 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272631005447 acyl-CoA synthetase; Validated; Region: PRK05850 272631005448 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272631005449 acyl-activating enzyme (AAE) consensus motif; other site 272631005450 active site 272631005451 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 272631005452 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272631005453 hypothetical protein (pseudogene) 272631005454 two-component response regulator (pseudogene) 272631005455 sensor histidine kinase (pseudogene) 272631005456 19 kDa antigenic lipoprotein 272631005457 probable alkyl sulfatase (pseudogene) 272631005458 acyl-CoA dehydrogenase (pseudogene) 272631005459 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 272631005460 similar to osmoprotection proteins (pseudogene) 272631005461 transposase (pseudogene) 272631005462 PPE-family protein (pseudogene) 272631005463 ECF-type sigma factor (pseudogene) 272631005464 conserved hypothetical protein (pseudogene) 272631005465 unknown fatty acid methyltransferase (pseudogene) 272631005466 conserved hypothetical protein (pseudogene) 272631005467 integral membrane protein (pseudogene) 272631005468 conserved large membrane protein (pseudogene) 272631005469 transcriptional regulator (pseudogene) 272631005470 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 272631005471 Transport protein; Region: actII; TIGR00833 272631005472 MMPL family; Region: MMPL; pfam03176 272631005473 MMPL family; Region: MMPL; pfam03176 272631005474 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 272631005475 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631005476 probable peptidase (pseudogene) 272631005477 aldehyde dehydrogenase (pseudogene) 272631005478 conserved hypothetical protein (pseudogene) 272631005479 conserved hypothetical protein (pseudogene) 272631005480 unknown possible membrane protein (pseudogene) 272631005481 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 272631005482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631005483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272631005484 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272631005485 conserved hypothetical protein (pseudogene) 272631005486 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 272631005487 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 272631005488 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272631005489 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272631005490 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272631005491 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272631005492 homodimer interface [polypeptide binding]; other site 272631005493 substrate-cofactor binding pocket; other site 272631005494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631005495 catalytic residue [active] 272631005496 RDD family; Region: RDD; pfam06271 272631005497 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 272631005498 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272631005499 dimer interface [polypeptide binding]; other site 272631005500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631005501 catalytic residue [active] 272631005502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 272631005503 probable esterase (pseudogene) 272631005504 conserved hypothetical protein (pseudogene) 272631005505 acetyl-CoA C-acetyltransferase (pseudogene) 272631005506 Predicted membrane protein [Function unknown]; Region: COG4760 272631005507 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 272631005508 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631005509 substrate binding site [chemical binding]; other site 272631005510 oxyanion hole (OAH) forming residues; other site 272631005511 trimer interface [polypeptide binding]; other site 272631005512 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 272631005513 enoyl-CoA hydratase; Provisional; Region: PRK05862 272631005514 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631005515 substrate binding site [chemical binding]; other site 272631005516 oxyanion hole (OAH) forming residues; other site 272631005517 trimer interface [polypeptide binding]; other site 272631005518 conserved hypothetical protein (pseudogene) 272631005519 UDP-glucose 4-epimerase (pseudogene) 272631005520 phosphorylase from Pnp/MtaP family 2 (pseudogene) 272631005521 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 272631005522 putative active site [active] 272631005523 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 272631005524 conserved hypothetical protein (pseudogene) 272631005525 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 272631005526 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 272631005527 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272631005528 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272631005529 catalytic residues [active] 272631005530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272631005531 catalytic core [active] 272631005532 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 272631005533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272631005534 inhibitor-cofactor binding pocket; inhibition site 272631005535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631005536 catalytic residue [active] 272631005537 conserved hypothetical protein (pseudogene) 272631005538 probable 4-amino butyrate transporter (pseudogene) 272631005539 conserved hypothetical protein (pseudogene) 272631005540 probable membrane protein (pseudogene) 272631005541 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 272631005542 dimer interface [polypeptide binding]; other site 272631005543 active site 272631005544 Schiff base residues; other site 272631005545 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 272631005546 active site 272631005547 homodimer interface [polypeptide binding]; other site 272631005548 SAM binding site [chemical binding]; other site 272631005549 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272631005550 active site 272631005551 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272631005552 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272631005553 domain interfaces; other site 272631005554 active site 272631005555 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 272631005556 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 272631005557 tRNA; other site 272631005558 putative tRNA binding site [nucleotide binding]; other site 272631005559 putative NADP binding site [chemical binding]; other site 272631005560 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 272631005561 hypothetical protein (pseudogene) 272631005562 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272631005563 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272631005564 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 272631005565 active site 272631005566 catalytic site [active] 272631005567 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272631005568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272631005569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631005570 S-adenosylmethionine binding site [chemical binding]; other site 272631005571 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 272631005572 putative acyl-acceptor binding pocket; other site 272631005573 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272631005574 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 272631005575 putative NAD(P) binding site [chemical binding]; other site 272631005576 active site 272631005577 putative substrate binding site [chemical binding]; other site 272631005578 DNA binding domain, excisionase family; Region: excise; TIGR01764 272631005579 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272631005580 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272631005581 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 272631005582 hypothetical protein (pseudogene) 272631005583 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272631005584 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272631005585 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 272631005586 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 272631005587 transcriptional regulator (GntR family) (pseudogene) 272631005588 conserved hypothetical protein (pseudogene) 272631005589 gmc-type oxidoreductase (pseudogene) 272631005590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272631005591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272631005592 active site 272631005593 phosphorylation site [posttranslational modification] 272631005594 intermolecular recognition site; other site 272631005595 dimerization interface [polypeptide binding]; other site 272631005596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272631005597 DNA binding site [nucleotide binding] 272631005598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272631005599 dimer interface [polypeptide binding]; other site 272631005600 phosphorylation site [posttranslational modification] 272631005601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272631005602 ATP binding site [chemical binding]; other site 272631005603 Mg2+ binding site [ion binding]; other site 272631005604 G-X-G motif; other site 272631005605 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 272631005606 ATP-binding site [chemical binding]; other site 272631005607 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272631005608 catalytic core [active] 272631005609 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 272631005610 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 272631005611 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 272631005612 putative ADP-binding pocket [chemical binding]; other site 272631005613 transcriptional regulator (ROK family) (pseudogene) 272631005614 oxidoreductase (pseudogene) 272631005615 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 272631005616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272631005617 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 272631005618 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272631005619 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 272631005620 FAD binding domain; Region: FAD_binding_4; pfam01565 272631005621 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272631005622 hypothetical protein (pseudogene) 272631005623 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 272631005624 putative active site [active] 272631005625 catalytic triad [active] 272631005626 putative dimer interface [polypeptide binding]; other site 272631005627 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 272631005628 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272631005629 intersubunit interface [polypeptide binding]; other site 272631005630 active site 272631005631 catalytic residue [active] 272631005632 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 272631005633 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 272631005634 transcriptional regulator (PbsX/Xre family) (pseudogene) 272631005635 possible membrane protein (pseudogene) 272631005636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631005637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272631005638 salt bridge; other site 272631005639 non-specific DNA binding site [nucleotide binding]; other site 272631005640 sequence-specific DNA binding site [nucleotide binding]; other site 272631005641 hypothetical protein (pseudogene) 272631005642 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272631005643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272631005644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631005645 S-adenosylmethionine binding site [chemical binding]; other site 272631005646 unknown mycolic acid methyltransferase (pseudogene) 272631005647 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 272631005648 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272631005649 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272631005650 isocitrate lyase (pseudogene) 272631005651 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 272631005652 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272631005653 active site 2 [active] 272631005654 active site 1 [active] 272631005655 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272631005656 active site 2 [active] 272631005657 transcriptional regulator (PbsX/Xre family) (pseudogene) 272631005658 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272631005659 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272631005660 possible hemolysin (pseudogene) 272631005661 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272631005662 active site 272631005663 dimer interface [polypeptide binding]; other site 272631005664 osmoprotection ABC transporter (pseudogene) 272631005665 transport system permease (pseudogene) 272631005666 hypothetical protein (pseudogene) 272631005667 prephenate dehydrogenase; Validated; Region: PRK06545 272631005668 prephenate dehydrogenase; Validated; Region: PRK08507 272631005669 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 272631005670 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272631005671 nucleoside/Zn binding site; other site 272631005672 dimer interface [polypeptide binding]; other site 272631005673 catalytic motif [active] 272631005674 possible glycerolphosphodiesterase (pseudogene) 272631005675 Uncharacterized conserved protein [Function unknown]; Region: COG0393 272631005676 PE protein (pseudogene) 272631005677 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 272631005678 conserved hypothetical protein (pseudogene) 272631005679 CO dehydrogenase gene cluster (pseudogene) 272631005680 CO dehydrogenase gene cluster (pseudogene) 272631005681 Possible membrane protein (pseudogene) 272631005682 conserved hypothetical protein (pseudogene) 272631005683 transcriptional regulator (LysR family) (pseudogene) 272631005684 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272631005685 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272631005686 hypothetical protein (pseudogene) 272631005687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272631005688 active site 272631005689 ketoacyl reductase (pseudogene) 272631005690 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272631005691 Clp amino terminal domain; Region: Clp_N; pfam02861 272631005692 Clp amino terminal domain; Region: Clp_N; pfam02861 272631005693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631005694 Walker A motif; other site 272631005695 ATP binding site [chemical binding]; other site 272631005696 Walker B motif; other site 272631005697 arginine finger; other site 272631005698 Sperm tail; Region: NYD-SP28; pfam14772 272631005699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631005700 Walker A motif; other site 272631005701 ATP binding site [chemical binding]; other site 272631005702 Walker B motif; other site 272631005703 arginine finger; other site 272631005704 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272631005705 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 272631005706 similar to oxidoreductases (pseudogene) 272631005707 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 272631005708 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272631005709 DNA binding residues [nucleotide binding] 272631005710 putative dimer interface [polypeptide binding]; other site 272631005711 chaperone protein DnaJ; Provisional; Region: PRK14279 272631005712 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272631005713 HSP70 interaction site [polypeptide binding]; other site 272631005714 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272631005715 Zn binding sites [ion binding]; other site 272631005716 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272631005717 dimer interface [polypeptide binding]; other site 272631005718 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272631005719 dimer interface [polypeptide binding]; other site 272631005720 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272631005721 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272631005722 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272631005723 nucleotide binding site [chemical binding]; other site 272631005724 NEF interaction site [polypeptide binding]; other site 272631005725 SBD interface [polypeptide binding]; other site 272631005726 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272631005727 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272631005728 substrate binding site [chemical binding]; other site 272631005729 oxyanion hole (OAH) forming residues; other site 272631005730 trimer interface [polypeptide binding]; other site 272631005731 CO dehydrogenase gene cluster (pseudogene) 272631005732 conserved hypothetical protein (pseudogene) 272631005733 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 272631005734 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272631005735 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272631005736 Cysteine-rich domain; Region: CCG; pfam02754 272631005737 Cysteine-rich domain; Region: CCG; pfam02754 272631005738 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 272631005739 aminotransferase AlaT; Validated; Region: PRK09265 272631005740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272631005741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272631005742 homodimer interface [polypeptide binding]; other site 272631005743 catalytic residue [active] 272631005744 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272631005745 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272631005746 substrate binding site; other site 272631005747 tetramer interface; other site 272631005748 hypothetical protein (pseudogene) 272631005749 hypothetical protein (pseudogene) 272631005750 UDP-glucose dehydrogenase/GDP-mannose (pseudogene) 272631005751 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272631005752 trimer interface [polypeptide binding]; other site 272631005753 active site 272631005754 conserved hypothetical protein (pseudogene) 272631005755 hypothetical protein (pseudogene) 272631005756 enoyl-CoA hydratase/isomerase superfamily (pseudogene) 272631005757 probable sugar transport protein (pseudogene) 272631005758 hypothetical protein (pseudogene) 272631005759 immunogenic protein Mpb64/Mpt64 (pseudogene) 272631005760 possible membrane protein (pseudogene) 272631005761 unknown membrane protein (pseudogene) 272631005762 probable [beta]-1,3-glucanase (pseudogene) 272631005763 unknown hydrophobic protein (pseudogene) 272631005764 conserved hypothetical protein (pseudogene) 272631005765 hypothetical protein (pseudogene) 272631005766 conserved hypothetical protein (pseudogene) 272631005767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 272631005768 conserved hypothetical protein (pseudogene) 272631005769 hypothetical protein (pseudogene) 272631005770 proable arylsulfatase (pseudogene) 272631005771 hypothetical protein (pseudogene) 272631005772 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 272631005773 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272631005774 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 272631005775 active site 272631005776 catalytic residues [active] 272631005777 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 272631005778 EspG family; Region: ESX-1_EspG; pfam14011 272631005779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272631005780 Proteins of 100 residues with WXG; Region: WXG100; cl02005 272631005781 PE-family protein (pseudogene) 272631005782 PE family; Region: PE; pfam00934 272631005783 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 272631005784 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631005785 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 272631005786 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631005787 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272631005788 Protein of unknown function (DUF690); Region: DUF690; pfam05108 272631005789 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 272631005790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272631005791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272631005792 Walker A motif; other site 272631005793 ATP binding site [chemical binding]; other site 272631005794 Walker B motif; other site 272631005795 arginine finger; other site 272631005796 PPE-family protein (pseudogene) 272631005797 conserved hypothetical protein (pseudogene) 272631005798 conserved hypothetical protein (pseudogene) 272631005799 acyl-CoA synthase (pseudogene) 272631005800 hypothetical protein (pseudogene) 272631005801 transcriptional regulator (pseudogene) 272631005802 hypothetical protein (pseudogene) 272631005803 acyl-CoA dehydrogenase (pseudogene) 272631005804 acyl-CoA synthetase; Validated; Region: PRK07788 272631005805 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631005806 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631005807 acyl-activating enzyme (AAE) consensus motif; other site 272631005808 acyl-activating enzyme (AAE) consensus motif; other site 272631005809 AMP binding site [chemical binding]; other site 272631005810 active site 272631005811 active site 272631005812 AMP binding site [chemical binding]; other site 272631005813 CoA binding site [chemical binding]; other site 272631005814 CoA binding site [chemical binding]; other site 272631005815 conserved hypothetical protein (pseudogene) 272631005816 iron transport protein FeIII dicitrate transporter (pseudogene) 272631005817 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 272631005818 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 272631005819 Predicted acetyltransferase [General function prediction only]; Region: COG3393 272631005820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272631005821 Coenzyme A binding pocket [chemical binding]; other site 272631005822 nitrite extrusion protein1 (pseudogene) 272631005823 conserved hypothetical protein (pseudogene) 272631005824 probable nitrite reductase small subunit (pseudogene) 272631005825 nitrite reductase flavoprotein (pseudogene) 272631005826 possible heat shock protein (pseudogene) 272631005827 probable membrane anchor protein (pseudogene) 272631005828 probable flavoprotein subunit of Rv0247c (pseudogene) 272631005829 probable iron-sulphur protein (pseudogene) 272631005830 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272631005831 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 272631005832 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 272631005833 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 272631005834 FAD binding site [chemical binding]; other site 272631005835 substrate binding site [chemical binding]; other site 272631005836 catalytic residues [active] 272631005837 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 272631005838 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 272631005839 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272631005840 dimer interface [polypeptide binding]; other site 272631005841 active site 272631005842 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 272631005843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272631005844 NAD(P) binding site [chemical binding]; other site 272631005845 active site 272631005846 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272631005847 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272631005848 active site 2 [active] 272631005849 active site 1 [active] 272631005850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631005851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631005852 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272631005853 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 272631005854 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 272631005855 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 272631005856 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 272631005857 glycerophosphoryl diester phosphodiesterase (pseudogene) 272631005858 conserved hypothetical protein (pseudogene) 272631005859 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 272631005860 NAD(P) binding site [chemical binding]; other site 272631005861 catalytic residues [active] 272631005862 ribonucleoside-diphosphate reductase B2 (pseudogene) 272631005863 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631005864 conserved hypothetical protein (pseudogene) 272631005865 hypothetical protein (pseudogene) 272631005866 acyl-CoA dehydrogenase (pseudogene) 272631005867 conserved hypothetical protein (pseudogene) 272631005868 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272631005869 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 272631005870 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 272631005871 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272631005872 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272631005873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631005874 S-adenosylmethionine binding site [chemical binding]; other site 272631005875 aldehyde dehydrogenase (possible betB) (pseudogene) 272631005876 acyl-CoA synthase (pseudogene) 272631005877 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272631005878 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272631005879 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 272631005880 mce related protein; Region: MCE; pfam02470 272631005881 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 272631005882 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272631005883 mce related protein; Region: MCE; pfam02470 272631005884 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 272631005885 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272631005886 mce related protein; Region: MCE; pfam02470 272631005887 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 272631005888 mce related protein; Region: MCE; pfam02470 272631005889 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 272631005890 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 272631005891 mce related protein; Region: MCE; pfam02470 272631005892 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272631005893 mce related protein; Region: MCE; pfam02470 272631005894 Predicted membrane protein/domain [Function unknown]; Region: COG1714 272631005895 lipoprotein (pseudogene) 272631005896 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 272631005897 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 272631005898 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 272631005899 conserved hypothetical protein (pseudogene) 272631005900 sigma-70 factors ECF subfamily (pseudogene) 272631005901 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272631005902 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272631005903 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 272631005904 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 272631005905 [beta]-glucosidase (pseudogene) 272631005906 polyketide synthase (pseudogene) 272631005907 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 272631005908 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 272631005909 putative homodimer interface [polypeptide binding]; other site 272631005910 putative homotetramer interface [polypeptide binding]; other site 272631005911 putative allosteric switch controlling residues; other site 272631005912 putative metal binding site [ion binding]; other site 272631005913 putative homodimer-homodimer interface [polypeptide binding]; other site 272631005914 probable chloramphenicol resistance protein (pseudogene) 272631005915 conserved hypothetical protein (pseudogene) 272631005916 conserved hypothetical protein (pseudogene) 272631005917 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272631005918 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272631005919 active site 272631005920 Zn binding site [ion binding]; other site 272631005921 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 272631005922 MMPL family; Region: MMPL; cl14618 272631005923 MMPL family; Region: MMPL; cl14618 272631005924 Predicted integral membrane protein [Function unknown]; Region: COG0392 272631005925 probable membrane protein (pseudogene) 272631005926 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 272631005927 MMPL family; Region: MMPL; cl14618 272631005928 MMPL family; Region: MMPL; cl14618 272631005929 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 272631005930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631005931 S-adenosylmethionine binding site [chemical binding]; other site 272631005932 hypothetical protein (pseudogene) 272631005933 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 272631005934 active site 272631005935 substrate-binding site [chemical binding]; other site 272631005936 metal-binding site [ion binding] 272631005937 GTP binding site [chemical binding]; other site 272631005938 acyl-CoA synthase (pseudogene) 272631005939 acyl-CoA dehydrogenase (pseudogene) 272631005940 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 272631005941 putative active site [active] 272631005942 putative catalytic site [active] 272631005943 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272631005944 active site 2 [active] 272631005945 active site 1 [active] 272631005946 acyl-CoA synthase (pseudogene) 272631005947 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 272631005948 putative hydrophobic ligand binding site [chemical binding]; other site 272631005949 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272631005950 FAD binding domain; Region: FAD_binding_4; pfam01565 272631005951 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272631005952 PE-family protein (pseudogene) 272631005953 transcriptional regulator (TetR/AcrR family) (pseudogene) 272631005954 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 272631005955 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 272631005956 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 272631005957 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 272631005958 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 272631005959 ligand binding site [chemical binding]; other site 272631005960 homodimer interface [polypeptide binding]; other site 272631005961 NAD(P) binding site [chemical binding]; other site 272631005962 trimer interface B [polypeptide binding]; other site 272631005963 trimer interface A [polypeptide binding]; other site 272631005964 acyl-CoA dehydrogenase (pseudogene) 272631005965 oxidoreductase (pseudogene) 272631005966 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 272631005967 NAD(P) binding site [chemical binding]; other site 272631005968 catalytic residues [active] 272631005969 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 272631005970 conserved hypothetical protein (pseudogene) 272631005971 transcriptional regulator (pseudogene) 272631005972 probable chloride channel (pseudogene) 272631005973 hypothetical protein (pseudogene) 272631005974 oxidoreductase (pseudogene) 272631005975 conserved hypothetical protein (pseudogene) 272631005976 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272631005977 cytochrome p450 (pseudogene) 272631005978 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272631005979 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 272631005980 NodB motif; other site 272631005981 active site 272631005982 catalytic site [active] 272631005983 metal binding site [ion binding]; metal-binding site 272631005984 conserved hypothetical protein (pseudogene) 272631005985 hypothetical protein (pseudogene) 272631005986 hypothetical protein (pseudogene) 272631005987 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272631005988 active site 272631005989 metal binding site [ion binding]; metal-binding site 272631005990 homotetramer interface [polypeptide binding]; other site 272631005991 Predicted esterase [General function prediction only]; Region: COG0627 272631005992 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 272631005993 conserved hypothetical protein (pseudogene) 272631005994 conserved hypothetical protein (pseudogene) 272631005995 probable glycosyl hydrolase (pseudogene) 272631005996 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272631005997 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272631005998 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272631005999 elongation factor G (pseudogene) 272631006000 acyl-CoA synthetase; Validated; Region: PRK05852 272631006001 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631006002 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272631006003 acyl-activating enzyme (AAE) consensus motif; other site 272631006004 acyl-activating enzyme (AAE) consensus motif; other site 272631006005 AMP binding site [chemical binding]; other site 272631006006 active site 272631006007 CoA binding site [chemical binding]; other site 272631006008 oxalyl-CoA decarboxylase (pseudogene) 272631006009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272631006010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272631006011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272631006012 dimerization interface [polypeptide binding]; other site 272631006013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272631006014 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 272631006015 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272631006016 acyl-CoA synthase (pseudogene) 272631006017 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 272631006018 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272631006019 hypothetical protein (pseudogene) 272631006020 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272631006021 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272631006022 active site 272631006023 catalytic triad [active] 272631006024 oxyanion hole [active] 272631006025 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272631006026 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272631006027 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272631006028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272631006029 motif II; other site 272631006030 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272631006031 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 272631006032 sensor histidine kinase (pseudogene) 272631006033 Region of low G+C content 39.32% 272631006034 possible membrane protein (pseudogene) 272631006035 probable ATP-binding transport protein (pseudogene) 272631006036 probable oxidoreductase (pseudogene) 272631006037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272631006038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272631006039 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272631006040 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272631006041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 272631006042 Uncharacterized conserved protein [Function unknown]; Region: COG2308 272631006043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 272631006044 replicative DNA helicase; Region: DnaB; TIGR00665 272631006045 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272631006046 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 272631006047 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272631006048 Walker A motif; other site 272631006049 ATP binding site [chemical binding]; other site 272631006050 Walker B motif; other site 272631006051 DNA binding loops [nucleotide binding] 272631006052 hypothetical protein (pseudogene) 272631006053 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272631006054 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272631006055 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272631006056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272631006057 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272631006058 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272631006059 dimer interface [polypeptide binding]; other site 272631006060 ssDNA binding site [nucleotide binding]; other site 272631006061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272631006062 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272631006063 conserved hypothetical protein (pseudogene) 272631006064 Predicted integral membrane protein [Function unknown]; Region: COG5650 272631006065 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272631006066 Transglycosylase; Region: Transgly; pfam00912 272631006067 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272631006068 hypothetical protein (pseudogene) 272631006069 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272631006070 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 272631006071 possible dihydrolipoamide acetyltransferase (pseudogene) 272631006072 possible monooxygenase (pseudogene) 272631006073 ABC transporter (pseudogene) 272631006074 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272631006075 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272631006076 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 272631006077 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272631006078 active site 272631006079 NTP binding site [chemical binding]; other site 272631006080 metal binding triad [ion binding]; metal-binding site 272631006081 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272631006082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272631006083 Zn2+ binding site [ion binding]; other site 272631006084 Mg2+ binding site [ion binding]; other site 272631006085 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272631006086 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 272631006087 active site 272631006088 Ap6A binding site [chemical binding]; other site 272631006089 nudix motif; other site 272631006090 metal binding site [ion binding]; metal-binding site 272631006091 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272631006092 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272631006093 probable sigma factor, similar to SigE (pseudogene) 272631006094 hypothetical protein (pseudogene) 272631006095 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272631006096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272631006097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272631006098 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272631006099 catalytic residues [active] 272631006100 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272631006101 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272631006102 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272631006103 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272631006104 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272631006105 active site 272631006106 metal binding site [ion binding]; metal-binding site 272631006107 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272631006108 ParB-like nuclease domain; Region: ParBc; pfam02195 272631006109 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272631006110 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272631006111 P-loop; other site 272631006112 Magnesium ion binding site [ion binding]; other site 272631006113 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272631006114 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272631006115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272631006116 S-adenosylmethionine binding site [chemical binding]; other site 272631006117 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 272631006118 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 272631006119 G-X-X-G motif; other site 272631006120 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 272631006121 RxxxH motif; other site 272631006122 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 272631006123 possible hemolysin (pseudogene) 272631006124 ribonuclease P; Reviewed; Region: rnpA; PRK00588 272631006125 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399