-- dump date   	20140619_153031
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
459424000001	Predicted membrane protein [Function unknown]; Region: COG5373
459424000002	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
459424000003	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
459424000004	P-loop; other site
459424000005	Magnesium ion binding site [ion binding]; other site
459424000006	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
459424000007	Magnesium ion binding site [ion binding]; other site
459424000008	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
459424000009	NlpC/P60 family; Region: NLPC_P60; cl17555
459424000010	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
459424000011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424000012	non-specific DNA binding site [nucleotide binding]; other site
459424000013	salt bridge; other site
459424000014	sequence-specific DNA binding site [nucleotide binding]; other site
459424000015	Transcription factor WhiB; Region: Whib; pfam02467
459424000016	NusA-like KH domain; Region: KH_5; pfam13184
459424000017	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
459424000018	G-X-X-G motif; other site
459424000019	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
459424000020	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424000021	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424000022	active site
459424000023	ATP binding site [chemical binding]; other site
459424000024	substrate binding site [chemical binding]; other site
459424000025	activation loop (A-loop); other site
459424000026	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424000027	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424000028	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424000029	active site
459424000030	ATP binding site [chemical binding]; other site
459424000031	substrate binding site [chemical binding]; other site
459424000032	activation loop (A-loop); other site
459424000033	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
459424000034	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
459424000035	intersubunit interface [polypeptide binding]; other site
459424000036	DivIVA domain; Region: DivI1A_domain; TIGR03544
459424000037	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424000038	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424000039	phosphopeptide binding site; other site
459424000040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424000041	non-specific DNA binding site [nucleotide binding]; other site
459424000042	salt bridge; other site
459424000043	sequence-specific DNA binding site [nucleotide binding]; other site
459424000044	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424000045	Transcription factor WhiB; Region: Whib; pfam02467
459424000046	RES domain; Region: RES; pfam08808
459424000047	Helix-turn-helix domain; Region: HTH_17; pfam12728
459424000048	Transposase [DNA replication, recombination, and repair]; Region: COG5421
459424000049	Transposase [DNA replication, recombination, and repair]; Region: COG5421
459424000050	Transposase, Mutator family; Region: Transposase_mut; pfam00872
459424000051	MULE transposase domain; Region: MULE; pfam10551
459424000052	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
459424000053	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
459424000054	Transposase [DNA replication, recombination, and repair]; Region: COG5421
459424000055	Transposase [DNA replication, recombination, and repair]; Region: COG5421
459424000056	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000057	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000058	active site
459424000059	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000060	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000061	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000062	putative NADP binding site [chemical binding]; other site
459424000063	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000064	active site
459424000065	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000066	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000067	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
459424000068	active site
459424000069	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424000070	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000071	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
459424000072	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000073	NADP binding site [chemical binding]; other site
459424000074	active site
459424000075	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000076	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000077	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
459424000078	active site
459424000079	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424000080	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000081	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
459424000082	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000083	NADP binding site [chemical binding]; other site
459424000084	active site
459424000085	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000086	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000087	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000088	active site
459424000089	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000090	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000091	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000092	putative NADP binding site [chemical binding]; other site
459424000093	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000094	active site
459424000095	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000096	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000097	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000098	active site
459424000099	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000100	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000101	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000102	putative NADP binding site [chemical binding]; other site
459424000103	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000104	active site
459424000105	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000106	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000107	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000108	active site
459424000109	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000110	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000111	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000112	putative NADP binding site [chemical binding]; other site
459424000113	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000114	active site
459424000115	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000116	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000117	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000118	active site
459424000119	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000120	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000121	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000122	putative NADP binding site [chemical binding]; other site
459424000123	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000124	active site
459424000125	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000126	Thioesterase; Region: PKS_TE; smart00824
459424000127	DDE domain; Region: DDE_Tnp_IS240; pfam13610
459424000128	Transposase; Region: DEDD_Tnp_IS110; pfam01548
459424000129	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
459424000130	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
459424000131	Transposase [DNA replication, recombination, and repair]; Region: COG5421
459424000132	Transposase [DNA replication, recombination, and repair]; Region: COG5421
459424000133	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424000134	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000135	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000136	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424000137	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424000138	Erythronolide synthase docking; Region: Docking; pfam08990
459424000139	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000140	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000141	active site
459424000142	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000143	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000144	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424000145	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424000146	Enoylreductase; Region: PKS_ER; smart00829
459424000147	NAD(P) binding site [chemical binding]; other site
459424000148	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000149	putative NADP binding site [chemical binding]; other site
459424000150	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000151	active site
459424000152	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000153	Thioesterase; Region: PKS_TE; smart00824
459424000154	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000155	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000156	active site
459424000157	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000158	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000159	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000160	putative NADP binding site [chemical binding]; other site
459424000161	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000162	active site
459424000163	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000164	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000165	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000166	active site
459424000167	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000168	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000169	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000170	putative NADP binding site [chemical binding]; other site
459424000171	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000172	active site
459424000173	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000174	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000175	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000176	active site
459424000177	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000178	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424000180	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424000181	Enoylreductase; Region: PKS_ER; smart00829
459424000182	NAD(P) binding site [chemical binding]; other site
459424000183	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000184	putative NADP binding site [chemical binding]; other site
459424000185	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000186	active site
459424000187	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000188	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000189	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000190	active site
459424000191	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000192	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000193	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000194	putative NADP binding site [chemical binding]; other site
459424000195	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000196	active site
459424000197	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000198	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000199	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000200	active site
459424000201	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000202	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424000204	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424000205	Enoylreductase; Region: PKS_ER; smart00829
459424000206	NAD(P) binding site [chemical binding]; other site
459424000207	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000208	putative NADP binding site [chemical binding]; other site
459424000209	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000210	active site
459424000211	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000212	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000213	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
459424000214	active site
459424000215	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424000216	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000217	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
459424000218	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000219	NADP binding site [chemical binding]; other site
459424000220	active site
459424000221	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000222	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000223	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000224	active site
459424000225	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000226	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000227	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000228	putative NADP binding site [chemical binding]; other site
459424000229	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000230	active site
459424000231	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000232	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000233	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000234	active site
459424000235	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000236	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000237	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424000238	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424000239	Enoylreductase; Region: PKS_ER; smart00829
459424000240	NAD(P) binding site [chemical binding]; other site
459424000241	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000242	putative NADP binding site [chemical binding]; other site
459424000243	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000244	active site
459424000245	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000246	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424000247	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424000248	active site
459424000249	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424000250	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424000251	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424000252	putative NADP binding site [chemical binding]; other site
459424000253	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424000254	active site
459424000255	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424000256	DDE domain; Region: DDE_Tnp_IS240; pfam13610
459424000257	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
459424000258	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
459424000259	dimer interface [polypeptide binding]; other site
459424000260	active site
459424000261	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
459424000262	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
459424000263	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
459424000264	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
459424000265	active site
459424000266	DNA binding site [nucleotide binding]
459424000267	Int/Topo IB signature motif; other site
459424000268	ERCC4 domain; Region: ERCC4; smart00891
459424000269	Lsr2; Region: Lsr2; pfam11774
459424000270	transposase/IS protein; Provisional; Region: PRK09183
459424000271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424000272	Walker A motif; other site
459424000273	ATP binding site [chemical binding]; other site
459424000274	Walker B motif; other site
459424000275	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
459424000276	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
459424000277	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
459424000278	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
459424000279	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424000280	Walker A motif; other site
459424000281	ATP binding site [chemical binding]; other site
459424000282	Walker B motif; other site
459424000283	arginine finger; other site
459424000284	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
459424000285	DnaA box-binding interface [nucleotide binding]; other site
459424000286	DNA polymerase III subunit beta; Validated; Region: PRK07761
459424000287	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
459424000288	putative DNA binding surface [nucleotide binding]; other site
459424000289	dimer interface [polypeptide binding]; other site
459424000290	beta-clamp/clamp loader binding surface; other site
459424000291	beta-clamp/translesion DNA polymerase binding surface; other site
459424000292	recF protein; Region: recf; TIGR00611
459424000293	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
459424000294	Walker A/P-loop; other site
459424000295	ATP binding site [chemical binding]; other site
459424000296	Q-loop/lid; other site
459424000297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424000298	ABC transporter signature motif; other site
459424000299	Walker B; other site
459424000300	D-loop; other site
459424000301	H-loop/switch region; other site
459424000302	hypothetical protein; Provisional; Region: PRK03195
459424000303	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
459424000304	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424000305	Mg2+ binding site [ion binding]; other site
459424000306	G-X-G motif; other site
459424000307	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
459424000308	anchoring element; other site
459424000309	dimer interface [polypeptide binding]; other site
459424000310	ATP binding site [chemical binding]; other site
459424000311	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
459424000312	active site
459424000313	putative metal-binding site [ion binding]; other site
459424000314	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
459424000315	DNA gyrase subunit A; Validated; Region: PRK05560
459424000316	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
459424000317	CAP-like domain; other site
459424000318	active site
459424000319	primary dimer interface [polypeptide binding]; other site
459424000320	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
459424000321	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
459424000322	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
459424000323	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
459424000324	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
459424000325	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
459424000326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424000327	S-adenosylmethionine binding site [chemical binding]; other site
459424000328	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
459424000329	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
459424000330	DNA binding residues [nucleotide binding]
459424000331	dimer interface [polypeptide binding]; other site
459424000332	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
459424000333	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
459424000334	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
459424000335	active site
459424000336	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
459424000337	putative septation inhibitor protein; Reviewed; Region: PRK00159
459424000338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
459424000339	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
459424000340	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
459424000341	Glutamine amidotransferase class-I; Region: GATase; pfam00117
459424000342	glutamine binding [chemical binding]; other site
459424000343	catalytic triad [active]
459424000344	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
459424000345	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424000346	active site
459424000347	ATP binding site [chemical binding]; other site
459424000348	substrate binding site [chemical binding]; other site
459424000349	activation loop (A-loop); other site
459424000350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
459424000351	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
459424000352	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
459424000353	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
459424000354	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
459424000355	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424000356	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424000357	active site
459424000358	ATP binding site [chemical binding]; other site
459424000359	substrate binding site [chemical binding]; other site
459424000360	activation loop (A-loop); other site
459424000361	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
459424000362	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
459424000363	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
459424000364	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
459424000365	active site
459424000366	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424000367	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424000368	phosphopeptide binding site; other site
459424000369	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
459424000370	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424000371	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424000372	phosphopeptide binding site; other site
459424000373	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
459424000374	ligand binding site [chemical binding]; other site
459424000375	active site
459424000376	classical (c) SDRs; Region: SDR_c; cd05233
459424000377	NAD(P) binding site [chemical binding]; other site
459424000378	active site
459424000379	hypothetical protein; Validated; Region: PRK02101
459424000380	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
459424000381	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
459424000382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424000383	dimer interface [polypeptide binding]; other site
459424000384	conserved gate region; other site
459424000385	ABC-ATPase subunit interface; other site
459424000386	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
459424000387	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
459424000388	Walker A/P-loop; other site
459424000389	ATP binding site [chemical binding]; other site
459424000390	Q-loop/lid; other site
459424000391	ABC transporter signature motif; other site
459424000392	Walker B; other site
459424000393	D-loop; other site
459424000394	H-loop/switch region; other site
459424000395	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
459424000396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424000397	putative PBP binding loops; other site
459424000398	dimer interface [polypeptide binding]; other site
459424000399	ABC-ATPase subunit interface; other site
459424000400	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
459424000401	DNA-binding site [nucleotide binding]; DNA binding site
459424000402	RNA-binding motif; other site
459424000403	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424000404	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
459424000405	active site
459424000406	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
459424000407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424000408	Coenzyme A binding pocket [chemical binding]; other site
459424000409	Pirin-related protein [General function prediction only]; Region: COG1741
459424000410	Pirin; Region: Pirin; pfam02678
459424000411	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
459424000412	Transcription factor WhiB; Region: Whib; pfam02467
459424000413	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
459424000414	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424000415	non-specific DNA binding site [nucleotide binding]; other site
459424000416	salt bridge; other site
459424000417	sequence-specific DNA binding site [nucleotide binding]; other site
459424000418	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
459424000419	NlpC/P60 family; Region: NLPC_P60; pfam00877
459424000420	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
459424000421	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
459424000422	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
459424000423	Protein of unknown function (DUF2694); Region: DUF2694; pfam10904
459424000424	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
459424000425	TIGR03084 family protein; Region: TIGR03084
459424000426	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
459424000427	Wyosine base formation; Region: Wyosine_form; pfam08608
459424000428	H+ Antiporter protein; Region: 2A0121; TIGR00900
459424000429	hypothetical protein; Validated; Region: PRK00228
459424000430	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
459424000431	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
459424000432	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
459424000433	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
459424000434	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
459424000435	active site
459424000436	HIGH motif; other site
459424000437	nucleotide binding site [chemical binding]; other site
459424000438	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
459424000439	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
459424000440	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
459424000441	active site
459424000442	KMSKS motif; other site
459424000443	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
459424000444	tRNA binding surface [nucleotide binding]; other site
459424000445	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
459424000446	short chain dehydrogenase; Provisional; Region: PRK08219
459424000447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424000448	NAD(P) binding site [chemical binding]; other site
459424000449	active site
459424000450	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424000451	MarR family; Region: MarR; pfam01047
459424000452	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
459424000453	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
459424000454	Walker A/P-loop; other site
459424000455	ATP binding site [chemical binding]; other site
459424000456	Q-loop/lid; other site
459424000457	ABC transporter signature motif; other site
459424000458	Walker B; other site
459424000459	D-loop; other site
459424000460	H-loop/switch region; other site
459424000461	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
459424000462	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
459424000463	substrate binding pocket [chemical binding]; other site
459424000464	membrane-bound complex binding site; other site
459424000465	hinge residues; other site
459424000466	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424000467	dimer interface [polypeptide binding]; other site
459424000468	conserved gate region; other site
459424000469	putative PBP binding loops; other site
459424000470	ABC-ATPase subunit interface; other site
459424000471	Transcriptional regulators [Transcription]; Region: GntR; COG1802
459424000472	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424000473	DNA-binding site [nucleotide binding]; DNA binding site
459424000474	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
459424000475	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424000476	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424000477	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
459424000478	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
459424000479	Predicted transcriptional regulators [Transcription]; Region: COG1695
459424000480	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
459424000481	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
459424000482	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
459424000483	Transglycosylase; Region: Transgly; pfam00912
459424000484	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
459424000485	Predicted integral membrane protein [Function unknown]; Region: COG5650
459424000486	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
459424000487	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
459424000488	conserved cys residue [active]
459424000489	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
459424000490	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
459424000491	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
459424000492	dimer interface [polypeptide binding]; other site
459424000493	ssDNA binding site [nucleotide binding]; other site
459424000494	tetramer (dimer of dimers) interface [polypeptide binding]; other site
459424000495	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
459424000496	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
459424000497	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
459424000498	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
459424000499	replicative DNA helicase; Region: DnaB; TIGR00665
459424000500	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
459424000501	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
459424000502	Walker A motif; other site
459424000503	ATP binding site [chemical binding]; other site
459424000504	Walker B motif; other site
459424000505	DNA binding loops [nucleotide binding]
459424000506	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424000507	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
459424000508	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
459424000509	Condensation domain; Region: Condensation; pfam00668
459424000510	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
459424000511	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000512	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000513	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
459424000514	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424000515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424000516	putative substrate translocation pore; other site
459424000517	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000518	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000519	Chorismate lyase; Region: Chor_lyase; cl01230
459424000520	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
459424000521	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
459424000522	2TM domain; Region: 2TM; pfam13239
459424000523	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
459424000524	active site
459424000525	catalytic site [active]
459424000526	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424000527	active site 2 [active]
459424000528	active site 1 [active]
459424000529	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
459424000530	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000531	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000532	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000533	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000534	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
459424000535	FAD binding domain; Region: FAD_binding_4; pfam01565
459424000536	Berberine and berberine like; Region: BBE; pfam08031
459424000537	PE family; Region: PE; pfam00934
459424000538	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424000539	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000540	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000541	haloalkane dehalogenase; Provisional; Region: PRK03592
459424000542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424000543	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
459424000544	Walker A motif; other site
459424000545	ATP binding site [chemical binding]; other site
459424000546	Walker B motif; other site
459424000547	arginine finger; other site
459424000548	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424000549	Cytochrome P450; Region: p450; cl12078
459424000550	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424000551	cyclase homology domain; Region: CHD; cd07302
459424000552	nucleotidyl binding site; other site
459424000553	metal binding site [ion binding]; metal-binding site
459424000554	dimer interface [polypeptide binding]; other site
459424000555	Predicted ATPase [General function prediction only]; Region: COG3903
459424000556	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
459424000557	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
459424000558	DNA binding residues [nucleotide binding]
459424000559	dimerization interface [polypeptide binding]; other site
459424000560	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
459424000561	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
459424000562	NAD(P) binding site [chemical binding]; other site
459424000563	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424000564	MarR family; Region: MarR_2; pfam12802
459424000565	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
459424000566	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
459424000567	NAD binding site [chemical binding]; other site
459424000568	catalytic Zn binding site [ion binding]; other site
459424000569	substrate binding site [chemical binding]; other site
459424000570	structural Zn binding site [ion binding]; other site
459424000571	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
459424000572	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424000573	catalytic loop [active]
459424000574	iron binding site [ion binding]; other site
459424000575	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
459424000576	FAD binding pocket [chemical binding]; other site
459424000577	conserved FAD binding motif [chemical binding]; other site
459424000578	phosphate binding motif [ion binding]; other site
459424000579	beta-alpha-beta structure motif; other site
459424000580	NAD binding pocket [chemical binding]; other site
459424000581	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
459424000582	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
459424000583	dimerization interface [polypeptide binding]; other site
459424000584	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
459424000585	dinuclear metal binding motif [ion binding]; other site
459424000586	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
459424000587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424000588	active site
459424000589	phosphorylation site [posttranslational modification]
459424000590	intermolecular recognition site; other site
459424000591	dimerization interface [polypeptide binding]; other site
459424000592	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
459424000593	DNA binding residues [nucleotide binding]
459424000594	dimerization interface [polypeptide binding]; other site
459424000595	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
459424000596	GAF domain; Region: GAF_2; pfam13185
459424000597	Histidine kinase; Region: HisKA_3; pfam07730
459424000598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424000599	ATP binding site [chemical binding]; other site
459424000600	Mg2+ binding site [ion binding]; other site
459424000601	G-X-G motif; other site
459424000602	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
459424000603	putative active site [active]
459424000604	putative CoA binding site [chemical binding]; other site
459424000605	nudix motif; other site
459424000606	metal binding site [ion binding]; metal-binding site
459424000607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424000608	Major Facilitator Superfamily; Region: MFS_1; pfam07690
459424000609	putative substrate translocation pore; other site
459424000610	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
459424000611	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424000612	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424000613	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424000614	active site
459424000615	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424000616	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424000617	active site
459424000618	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424000619	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000620	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000621	acetyl-CoA acetyltransferase; Validated; Region: PRK06157
459424000622	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424000623	active site
459424000624	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
459424000625	DUF35 OB-fold domain; Region: DUF35; pfam01796
459424000626	Transcriptional regulators [Transcription]; Region: MarR; COG1846
459424000627	MarR family; Region: MarR; pfam01047
459424000628	Predicted ATPase [General function prediction only]; Region: COG4637
459424000629	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424000630	Walker A/P-loop; other site
459424000631	ATP binding site [chemical binding]; other site
459424000632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424000633	ABC transporter signature motif; other site
459424000634	Walker B; other site
459424000635	D-loop; other site
459424000636	H-loop/switch region; other site
459424000637	CAAX protease self-immunity; Region: Abi; pfam02517
459424000638	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
459424000639	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
459424000640	homodimer interface [polypeptide binding]; other site
459424000641	active site
459424000642	TDP-binding site; other site
459424000643	acceptor substrate-binding pocket; other site
459424000644	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424000645	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424000646	active site
459424000647	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000648	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000649	hypothetical protein; Provisional; Region: PRK01346
459424000650	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424000651	Coenzyme A binding pocket [chemical binding]; other site
459424000652	Predicted transcriptional regulators [Transcription]; Region: COG1695
459424000653	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
459424000654	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
459424000655	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424000656	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
459424000657	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424000658	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
459424000659	putative active site [active]
459424000660	putative substrate binding site [chemical binding]; other site
459424000661	ATP binding site [chemical binding]; other site
459424000662	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424000663	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424000664	active site
459424000665	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424000666	cyclase homology domain; Region: CHD; cd07302
459424000667	nucleotidyl binding site; other site
459424000668	metal binding site [ion binding]; metal-binding site
459424000669	dimer interface [polypeptide binding]; other site
459424000670	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
459424000671	Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
459424000672	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424000673	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000674	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000675	Mannan-binding protein; Region: MVL; pfam12151
459424000676	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424000677	Coenzyme A binding pocket [chemical binding]; other site
459424000678	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
459424000679	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
459424000680	putative NADP binding site [chemical binding]; other site
459424000681	putative substrate binding site [chemical binding]; other site
459424000682	active site
459424000683	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
459424000684	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424000685	inhibitor-cofactor binding pocket; inhibition site
459424000686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424000687	catalytic residue [active]
459424000688	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
459424000689	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424000690	catalytic residue [active]
459424000691	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
459424000692	hydrophobic ligand binding site; other site
459424000693	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
459424000694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424000695	Walker A/P-loop; other site
459424000696	ATP binding site [chemical binding]; other site
459424000697	Q-loop/lid; other site
459424000698	ABC transporter signature motif; other site
459424000699	Walker B; other site
459424000700	D-loop; other site
459424000701	H-loop/switch region; other site
459424000702	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424000703	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
459424000704	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424000705	acyl-activating enzyme (AAE) consensus motif; other site
459424000706	active site
459424000707	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
459424000708	Permease; Region: Permease; pfam02405
459424000709	Permease; Region: Permease; pfam02405
459424000710	mce related protein; Region: MCE; pfam02470
459424000711	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424000712	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
459424000713	mce related protein; Region: MCE; pfam02470
459424000714	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424000715	mce related protein; Region: MCE; pfam02470
459424000716	mce related protein; Region: MCE; pfam02470
459424000717	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424000718	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424000719	mce related protein; Region: MCE; pfam02470
459424000720	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424000721	mce related protein; Region: MCE; pfam02470
459424000722	PE family; Region: PE; pfam00934
459424000723	Proteins of 100 residues with WXG; Region: WXG100; cl02005
459424000724	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000725	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000726	hypothetical protein; Validated; Region: PRK07121
459424000727	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
459424000728	Predicted oxidoreductase [General function prediction only]; Region: COG3573
459424000729	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
459424000730	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
459424000731	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
459424000732	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
459424000733	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
459424000734	dimer interface [polypeptide binding]; other site
459424000735	active site
459424000736	glycine-pyridoxal phosphate binding site [chemical binding]; other site
459424000737	folate binding site [chemical binding]; other site
459424000738	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
459424000739	lipoyl attachment site [posttranslational modification]; other site
459424000740	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
459424000741	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
459424000742	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
459424000743	glycine dehydrogenase; Provisional; Region: PRK05367
459424000744	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
459424000745	tetramer interface [polypeptide binding]; other site
459424000746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424000747	catalytic residue [active]
459424000748	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
459424000749	tetramer interface [polypeptide binding]; other site
459424000750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424000751	catalytic residue [active]
459424000752	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
459424000753	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
459424000754	[2Fe-2S] cluster binding site [ion binding]; other site
459424000755	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
459424000756	hydrophobic ligand binding site; other site
459424000757	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424000758	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
459424000759	active site
459424000760	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424000761	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
459424000762	anti sigma factor interaction site; other site
459424000763	regulatory phosphorylation site [posttranslational modification]; other site
459424000764	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
459424000765	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
459424000766	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
459424000767	Walker A/P-loop; other site
459424000768	ATP binding site [chemical binding]; other site
459424000769	Q-loop/lid; other site
459424000770	ABC transporter signature motif; other site
459424000771	Walker B; other site
459424000772	D-loop; other site
459424000773	H-loop/switch region; other site
459424000774	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424000775	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424000776	ligand binding site [chemical binding]; other site
459424000777	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000778	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000779	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000780	Acyltransferase family; Region: Acyl_transf_3; pfam01757
459424000781	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424000782	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000783	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000784	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
459424000785	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000786	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424000787	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000789	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000790	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000791	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
459424000792	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424000793	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
459424000794	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
459424000795	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
459424000796	[2Fe-2S] cluster binding site [ion binding]; other site
459424000797	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
459424000798	putative alpha subunit interface [polypeptide binding]; other site
459424000799	putative active site [active]
459424000800	putative substrate binding site [chemical binding]; other site
459424000801	Fe binding site [ion binding]; other site
459424000802	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
459424000803	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
459424000804	metal-binding site [ion binding]
459424000805	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424000806	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
459424000807	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
459424000808	metal-binding site [ion binding]
459424000809	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
459424000810	putative hydrophobic ligand binding site [chemical binding]; other site
459424000811	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
459424000812	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
459424000813	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424000814	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000815	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000816	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000817	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424000818	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000819	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000820	Predicted membrane protein [Function unknown]; Region: COG3305
459424000821	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
459424000822	CoenzymeA binding site [chemical binding]; other site
459424000823	subunit interaction site [polypeptide binding]; other site
459424000824	PHB binding site; other site
459424000825	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424000826	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
459424000827	NAD(P) binding site [chemical binding]; other site
459424000828	active site
459424000829	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
459424000830	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
459424000831	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
459424000832	putative hydrophobic ligand binding site [chemical binding]; other site
459424000833	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
459424000834	classical (c) SDRs; Region: SDR_c; cd05233
459424000835	NAD(P) binding site [chemical binding]; other site
459424000836	active site
459424000837	Transport protein; Region: actII; TIGR00833
459424000838	AMP-binding enzyme; Region: AMP-binding; pfam00501
459424000839	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424000840	acyl-activating enzyme (AAE) consensus motif; other site
459424000841	AMP binding site [chemical binding]; other site
459424000842	active site
459424000843	CoA binding site [chemical binding]; other site
459424000844	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424000845	NAD(P) binding site [chemical binding]; other site
459424000846	active site
459424000847	Phosphopantetheine attachment site; Region: PP-binding; cl09936
459424000848	acyl-CoA synthetase; Validated; Region: PRK05857
459424000849	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424000850	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
459424000851	acyl-activating enzyme (AAE) consensus motif; other site
459424000852	acyl-activating enzyme (AAE) consensus motif; other site
459424000853	AMP binding site [chemical binding]; other site
459424000854	active site
459424000855	CoA binding site [chemical binding]; other site
459424000856	FcoT-like thioesterase domain; Region: FcoT; pfam10862
459424000857	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
459424000858	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
459424000859	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424000860	PPE family; Region: PPE; pfam00823
459424000861	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424000862	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
459424000863	Predicted integral membrane protein [Function unknown]; Region: COG5660
459424000864	Putative zinc-finger; Region: zf-HC2; pfam13490
459424000865	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
459424000866	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
459424000867	metal-binding site [ion binding]
459424000868	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424000869	Soluble P-type ATPase [General function prediction only]; Region: COG4087
459424000870	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
459424000871	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424000872	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424000873	DNA binding residues [nucleotide binding]
459424000874	Predicted membrane protein [Function unknown]; Region: COG3336
459424000875	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
459424000876	metal-binding site [ion binding]
459424000877	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
459424000878	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
459424000879	metal-binding site [ion binding]
459424000880	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424000881	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
459424000882	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
459424000883	classical (c) SDRs; Region: SDR_c; cd05233
459424000884	NAD(P) binding site [chemical binding]; other site
459424000885	active site
459424000886	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424000887	Cytochrome P450; Region: p450; cl12078
459424000888	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424000889	Cytochrome P450; Region: p450; cl12078
459424000890	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424000891	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
459424000892	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
459424000893	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
459424000894	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
459424000895	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
459424000896	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424000897	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000898	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000899	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
459424000900	substrate binding pocket [chemical binding]; other site
459424000901	substrate-Mg2+ binding site; other site
459424000902	aspartate-rich region 2; other site
459424000903	Cytochrome P450; Region: p450; cl12078
459424000904	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424000905	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
459424000906	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
459424000907	substrate binding pocket [chemical binding]; other site
459424000908	chain length determination region; other site
459424000909	substrate-Mg2+ binding site; other site
459424000910	catalytic residues [active]
459424000911	aspartate-rich region 1; other site
459424000912	active site lid residues [active]
459424000913	aspartate-rich region 2; other site
459424000914	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424000915	Cytochrome P450; Region: p450; cl12078
459424000916	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
459424000917	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424000918	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424000919	ligand binding site [chemical binding]; other site
459424000920	flexible hinge region; other site
459424000921	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424000922	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424000923	cyclase homology domain; Region: CHD; cd07302
459424000924	nucleotidyl binding site; other site
459424000925	metal binding site [ion binding]; metal-binding site
459424000926	dimer interface [polypeptide binding]; other site
459424000927	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424000928	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424000929	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
459424000930	30S ribosomal protein S18; Provisional; Region: PRK13401
459424000931	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
459424000932	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
459424000933	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
459424000934	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
459424000935	short chain dehydrogenase; Provisional; Region: PRK07454
459424000936	classical (c) SDRs; Region: SDR_c; cd05233
459424000937	NAD(P) binding site [chemical binding]; other site
459424000938	active site
459424000939	acyl-CoA synthetase; Provisional; Region: PRK13383
459424000940	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424000941	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424000942	AMP binding site [chemical binding]; other site
459424000943	active site
459424000944	acyl-activating enzyme (AAE) consensus motif; other site
459424000945	CoA binding site [chemical binding]; other site
459424000946	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424000947	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
459424000948	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
459424000949	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424000950	motif II; other site
459424000951	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
459424000952	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424000953	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000954	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000955	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424000956	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424000957	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424000958	PE family; Region: PE; pfam00934
459424000959	Rhomboid family; Region: Rhomboid; pfam01694
459424000960	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
459424000961	hydrophobic ligand binding site; other site
459424000962	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
459424000963	classical (c) SDRs; Region: SDR_c; cd05233
459424000964	NAD(P) binding site [chemical binding]; other site
459424000965	active site
459424000966	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
459424000967	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
459424000968	acyl-activating enzyme (AAE) consensus motif; other site
459424000969	putative AMP binding site [chemical binding]; other site
459424000970	putative active site [active]
459424000971	putative CoA binding site [chemical binding]; other site
459424000972	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
459424000973	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424000974	DNA-binding site [nucleotide binding]; DNA binding site
459424000975	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
459424000976	PQQ-like domain; Region: PQQ_2; pfam13360
459424000977	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
459424000978	classical (c) SDRs; Region: SDR_c; cd05233
459424000979	NAD(P) binding site [chemical binding]; other site
459424000980	active site
459424000981	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
459424000982	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
459424000983	[2Fe-2S] cluster binding site [ion binding]; other site
459424000984	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
459424000985	hydrophobic ligand binding site; other site
459424000986	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424000987	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424000988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424000989	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
459424000990	NAD(P) binding site [chemical binding]; other site
459424000991	active site
459424000992	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424000993	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424000994	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
459424000995	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
459424000996	active site
459424000997	catalytic triad [active]
459424000998	oxyanion hole [active]
459424000999	Methyltransferase domain; Region: Methyltransf_24; pfam13578
459424001000	S-adenosylmethionine binding site [chemical binding]; other site
459424001001	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
459424001002	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
459424001003	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
459424001004	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
459424001005	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
459424001006	Transcriptional regulator [Transcription]; Region: LysR; COG0583
459424001007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
459424001008	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
459424001009	dimerization interface [polypeptide binding]; other site
459424001010	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
459424001011	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
459424001012	PYR/PP interface [polypeptide binding]; other site
459424001013	dimer interface [polypeptide binding]; other site
459424001014	TPP binding site [chemical binding]; other site
459424001015	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
459424001016	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
459424001017	TPP-binding site; other site
459424001018	dimer interface [polypeptide binding]; other site
459424001019	acyl-CoA synthetase; Validated; Region: PRK05852
459424001020	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424001021	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
459424001022	acyl-activating enzyme (AAE) consensus motif; other site
459424001023	acyl-activating enzyme (AAE) consensus motif; other site
459424001024	putative AMP binding site [chemical binding]; other site
459424001025	putative active site [active]
459424001026	putative CoA binding site [chemical binding]; other site
459424001027	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
459424001028	elongation factor G; Reviewed; Region: PRK12740
459424001029	G1 box; other site
459424001030	putative GEF interaction site [polypeptide binding]; other site
459424001031	GTP/Mg2+ binding site [chemical binding]; other site
459424001032	Switch I region; other site
459424001033	G2 box; other site
459424001034	G3 box; other site
459424001035	Switch II region; other site
459424001036	G4 box; other site
459424001037	G5 box; other site
459424001038	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
459424001039	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
459424001040	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
459424001041	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
459424001042	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
459424001043	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
459424001044	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
459424001045	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
459424001046	protein binding site [polypeptide binding]; other site
459424001047	trehalose synthase; Region: treS_nterm; TIGR02456
459424001048	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
459424001049	active site
459424001050	catalytic site [active]
459424001051	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
459424001052	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
459424001053	Predicted membrane protein [Function unknown]; Region: COG3619
459424001054	Putative esterase; Region: Esterase; pfam00756
459424001055	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
459424001056	active site
459424001057	metal binding site [ion binding]; metal-binding site
459424001058	homotetramer interface [polypeptide binding]; other site
459424001059	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
459424001060	putative active site [active]
459424001061	putative catalytic site [active]
459424001062	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424001063	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424001064	active site
459424001065	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
459424001066	Coenzyme A binding pocket [chemical binding]; other site
459424001067	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424001068	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424001069	ligand binding site [chemical binding]; other site
459424001070	flexible hinge region; other site
459424001071	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424001072	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424001073	ligand binding site [chemical binding]; other site
459424001074	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
459424001075	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001076	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
459424001077	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
459424001078	FAD binding pocket [chemical binding]; other site
459424001079	FAD binding motif [chemical binding]; other site
459424001080	phosphate binding motif [ion binding]; other site
459424001081	beta-alpha-beta structure motif; other site
459424001082	NAD binding pocket [chemical binding]; other site
459424001083	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424001084	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
459424001085	catalytic loop [active]
459424001086	iron binding site [ion binding]; other site
459424001087	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
459424001088	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
459424001089	putative di-iron ligands [ion binding]; other site
459424001090	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
459424001091	hydrophobic ligand binding site; other site
459424001092	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001093	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001094	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424001095	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424001096	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
459424001097	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
459424001098	putative NAD(P) binding site [chemical binding]; other site
459424001099	catalytic Zn binding site [ion binding]; other site
459424001100	structural Zn binding site [ion binding]; other site
459424001101	TOBE domain; Region: TOBE; cl01440
459424001102	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001103	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001104	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424001105	Cytochrome P450; Region: p450; cl12078
459424001106	methionine sulfoxide reductase A; Provisional; Region: PRK14054
459424001107	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424001108	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
459424001109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424001110	NAD(P) binding site [chemical binding]; other site
459424001111	active site
459424001112	Domain of unknown function (DUF427); Region: DUF427; cl00998
459424001113	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
459424001114	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
459424001115	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
459424001116	minor groove reading motif; other site
459424001117	helix-hairpin-helix signature motif; other site
459424001118	active site
459424001119	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
459424001120	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
459424001121	Cl- selectivity filter; other site
459424001122	Cl- binding residues [ion binding]; other site
459424001123	pore gating glutamate residue; other site
459424001124	dimer interface [polypeptide binding]; other site
459424001125	Pirin-related protein [General function prediction only]; Region: COG1741
459424001126	Pirin; Region: Pirin; pfam02678
459424001127	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
459424001128	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001129	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001130	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424001131	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424001132	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424001133	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424001134	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424001135	Leucine carboxyl methyltransferase; Region: LCM; cl01306
459424001136	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
459424001137	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
459424001138	NAD(P) binding site [chemical binding]; other site
459424001139	catalytic residues [active]
459424001140	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
459424001141	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
459424001142	homodimer interface [polypeptide binding]; other site
459424001143	NAD binding site [chemical binding]; other site
459424001144	active site
459424001145	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
459424001146	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
459424001147	NAD(P) binding site [chemical binding]; other site
459424001148	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424001149	FMN binding site [chemical binding]; other site
459424001150	dimer interface [polypeptide binding]; other site
459424001151	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424001152	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424001153	active site
459424001154	ATP binding site [chemical binding]; other site
459424001155	substrate binding site [chemical binding]; other site
459424001156	activation loop (A-loop); other site
459424001157	Predicted ATPase [General function prediction only]; Region: COG3903
459424001158	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
459424001159	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001160	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001161	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001162	PE family; Region: PE; pfam00934
459424001163	PE-PPE domain; Region: PE-PPE; pfam08237
459424001164	PE family; Region: PE; pfam00934
459424001165	PE-PPE domain; Region: PE-PPE; pfam08237
459424001166	PE family; Region: PE; pfam00934
459424001167	PE-PPE domain; Region: PE-PPE; pfam08237
459424001168	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001169	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001170	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001171	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
459424001172	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
459424001173	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
459424001174	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424001175	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
459424001176	FAD binding site [chemical binding]; other site
459424001177	substrate binding site [chemical binding]; other site
459424001178	catalytic base [active]
459424001179	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424001180	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
459424001181	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
459424001182	ligand binding site [chemical binding]; other site
459424001183	homodimer interface [polypeptide binding]; other site
459424001184	NAD(P) binding site [chemical binding]; other site
459424001185	trimer interface B [polypeptide binding]; other site
459424001186	trimer interface A [polypeptide binding]; other site
459424001187	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
459424001188	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
459424001189	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
459424001190	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
459424001191	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001192	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001193	PE family; Region: PE; pfam00934
459424001194	PE-PPE domain; Region: PE-PPE; pfam08237
459424001195	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001196	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
459424001197	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424001198	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
459424001199	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
459424001200	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
459424001201	homotetramer interface [polypeptide binding]; other site
459424001202	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424001203	NAD binding site [chemical binding]; other site
459424001204	homodimer interface [polypeptide binding]; other site
459424001205	active site
459424001206	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
459424001207	FAD binding domain; Region: FAD_binding_4; pfam01565
459424001208	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001209	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001210	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
459424001211	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
459424001212	Strictosidine synthase; Region: Str_synth; pfam03088
459424001213	acyl-CoA thioesterase II; Region: tesB; TIGR00189
459424001214	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
459424001215	active site
459424001216	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
459424001217	catalytic triad [active]
459424001218	dimer interface [polypeptide binding]; other site
459424001219	Domain of unknown function (DUF427); Region: DUF427; cl00998
459424001220	Domain of unknown function (DUF427); Region: DUF427; pfam04248
459424001221	Ecdysteroid kinase; Region: EcKinase; cl17738
459424001222	Phosphotransferase enzyme family; Region: APH; pfam01636
459424001223	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424001224	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424001225	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424001226	Cytochrome P450; Region: p450; cl12078
459424001227	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
459424001228	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
459424001229	NAD(P) binding site [chemical binding]; other site
459424001230	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
459424001231	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
459424001232	classical (c) SDRs; Region: SDR_c; cd05233
459424001233	NAD(P) binding site [chemical binding]; other site
459424001234	active site
459424001235	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424001236	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424001237	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424001238	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424001239	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
459424001240	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
459424001241	NAD(P) binding site [chemical binding]; other site
459424001242	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
459424001243	active site
459424001244	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
459424001245	putative hydrophobic ligand binding site [chemical binding]; other site
459424001246	Transcriptional regulators [Transcription]; Region: FadR; COG2186
459424001247	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424001248	DNA-binding site [nucleotide binding]; DNA binding site
459424001249	FCD domain; Region: FCD; pfam07729
459424001250	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
459424001251	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424001252	acyl-activating enzyme (AAE) consensus motif; other site
459424001253	AMP binding site [chemical binding]; other site
459424001254	active site
459424001255	CoA binding site [chemical binding]; other site
459424001256	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
459424001257	Permease; Region: Permease; pfam02405
459424001258	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
459424001259	Permease; Region: Permease; pfam02405
459424001260	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424001261	mce related protein; Region: MCE; pfam02470
459424001262	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424001263	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424001264	mce related protein; Region: MCE; pfam02470
459424001265	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424001266	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424001267	mce related protein; Region: MCE; pfam02470
459424001268	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424001269	mce related protein; Region: MCE; pfam02470
459424001270	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424001271	mce related protein; Region: MCE; pfam02470
459424001272	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
459424001273	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424001274	mce related protein; Region: MCE; pfam02470
459424001275	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
459424001276	Predicted membrane protein [Function unknown]; Region: COG1511
459424001277	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
459424001278	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
459424001279	RNA polymerase factor sigma-70; Validated; Region: PRK08241
459424001280	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424001281	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424001282	DNA binding residues [nucleotide binding]
459424001283	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424001284	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
459424001285	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424001286	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
459424001287	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
459424001288	PE family; Region: PE; pfam00934
459424001289	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
459424001290	6-phosphogluconate dehydratase; Region: edd; TIGR01196
459424001291	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
459424001292	putative homodimer interface [polypeptide binding]; other site
459424001293	putative homotetramer interface [polypeptide binding]; other site
459424001294	putative allosteric switch controlling residues; other site
459424001295	putative metal binding site [ion binding]; other site
459424001296	putative homodimer-homodimer interface [polypeptide binding]; other site
459424001297	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
459424001298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424001299	putative substrate translocation pore; other site
459424001300	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
459424001301	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
459424001302	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
459424001303	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001304	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424001306	non-specific DNA binding site [nucleotide binding]; other site
459424001307	salt bridge; other site
459424001308	sequence-specific DNA binding site [nucleotide binding]; other site
459424001309	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
459424001310	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
459424001311	Predicted integral membrane protein [Function unknown]; Region: COG0392
459424001312	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
459424001313	Domain of unknown function DUF20; Region: UPF0118; pfam01594
459424001314	MMPL family; Region: MMPL; pfam03176
459424001315	MMPL family; Region: MMPL; pfam03176
459424001316	LabA_like proteins; Region: LabA_like; cd06167
459424001317	putative metal binding site [ion binding]; other site
459424001318	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
459424001319	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
459424001320	active site
459424001321	substrate-binding site [chemical binding]; other site
459424001322	metal-binding site [ion binding]
459424001323	GTP binding site [chemical binding]; other site
459424001324	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424001325	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
459424001326	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
459424001327	acyl-activating enzyme (AAE) consensus motif; other site
459424001328	acyl-activating enzyme (AAE) consensus motif; other site
459424001329	putative AMP binding site [chemical binding]; other site
459424001330	putative active site [active]
459424001331	putative CoA binding site [chemical binding]; other site
459424001332	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424001333	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424001334	substrate binding site [chemical binding]; other site
459424001335	oxyanion hole (OAH) forming residues; other site
459424001336	trimer interface [polypeptide binding]; other site
459424001337	Interferon-induced transmembrane protein; Region: CD225; pfam04505
459424001338	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
459424001339	putative active site [active]
459424001340	putative catalytic site [active]
459424001341	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424001342	active site 2 [active]
459424001343	active site 1 [active]
459424001344	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424001345	Amidohydrolase family; Region: Amidohydro_3; pfam07969
459424001346	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424001347	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424001348	active site
459424001349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424001350	S-adenosylmethionine binding site [chemical binding]; other site
459424001351	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
459424001352	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
459424001353	Moco binding site; other site
459424001354	metal coordination site [ion binding]; other site
459424001355	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424001356	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424001357	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424001358	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424001359	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424001360	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
459424001361	enoyl-CoA hydratase; Provisional; Region: PRK08252
459424001362	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424001363	substrate binding site [chemical binding]; other site
459424001364	oxyanion hole (OAH) forming residues; other site
459424001365	trimer interface [polypeptide binding]; other site
459424001366	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
459424001367	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424001368	acyl-activating enzyme (AAE) consensus motif; other site
459424001369	AMP binding site [chemical binding]; other site
459424001370	active site
459424001371	CoA binding site [chemical binding]; other site
459424001372	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424001373	AMP-binding enzyme; Region: AMP-binding; pfam00501
459424001374	acyl-activating enzyme (AAE) consensus motif; other site
459424001375	active site
459424001376	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001377	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001378	enoyl-CoA hydratase; Provisional; Region: PRK06563
459424001379	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424001380	substrate binding site [chemical binding]; other site
459424001381	oxyanion hole (OAH) forming residues; other site
459424001382	trimer interface [polypeptide binding]; other site
459424001383	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
459424001384	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
459424001385	NAD binding site [chemical binding]; other site
459424001386	catalytic residues [active]
459424001387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424001388	S-adenosylmethionine binding site [chemical binding]; other site
459424001389	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
459424001390	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424001391	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
459424001392	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
459424001393	PE family; Region: PE; pfam00934
459424001394	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001395	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001396	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001397	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
459424001398	homodimer interaction site [polypeptide binding]; other site
459424001399	substrate binding pocket [chemical binding]; other site
459424001400	active site
459424001401	PE family; Region: PE; pfam00934
459424001402	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
459424001403	active site
459424001404	catalytic site [active]
459424001405	substrate binding site [chemical binding]; other site
459424001406	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001407	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001408	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001409	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424001410	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
459424001411	active site
459424001412	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001413	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001414	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
459424001415	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
459424001416	NAD(P) binding site [chemical binding]; other site
459424001417	catalytic residues [active]
459424001418	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001419	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001420	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001421	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424001422	PPE family; Region: PPE; pfam00823
459424001423	PE family; Region: PE; pfam00934
459424001424	Lipase maturation factor; Region: LMF1; pfam06762
459424001425	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
459424001426	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
459424001427	putative active site [active]
459424001428	catalytic site [active]
459424001429	putative metal binding site [ion binding]; other site
459424001430	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
459424001431	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
459424001432	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
459424001433	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
459424001434	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
459424001435	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001436	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001437	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424001438	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424001439	active site 2 [active]
459424001440	active site 1 [active]
459424001441	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
459424001442	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424001443	NAD(P) binding site [chemical binding]; other site
459424001444	active site
459424001445	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
459424001446	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424001447	dimer interface [polypeptide binding]; other site
459424001448	active site
459424001449	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
459424001450	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
459424001451	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
459424001452	FAD binding site [chemical binding]; other site
459424001453	substrate binding site [chemical binding]; other site
459424001454	catalytic residues [active]
459424001455	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
459424001456	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
459424001457	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001458	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001459	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001460	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
459424001461	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424001462	catalytic loop [active]
459424001463	iron binding site [ion binding]; other site
459424001464	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
459424001465	L-aspartate oxidase; Provisional; Region: PRK06175
459424001466	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
459424001467	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
459424001468	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
459424001469	tetramer interface [polypeptide binding]; other site
459424001470	active site
459424001471	Mg2+/Mn2+ binding site [ion binding]; other site
459424001472	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
459424001473	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
459424001474	putative dimer interface [polypeptide binding]; other site
459424001475	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
459424001476	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424001477	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424001478	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
459424001479	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
459424001480	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
459424001481	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
459424001482	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
459424001483	putative active site [active]
459424001484	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
459424001485	active site
459424001486	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
459424001487	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
459424001488	active site
459424001489	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
459424001490	DNA binding site [nucleotide binding]
459424001491	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424001492	Coenzyme A binding pocket [chemical binding]; other site
459424001493	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
459424001494	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
459424001495	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
459424001496	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
459424001497	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
459424001498	intersubunit interface [polypeptide binding]; other site
459424001499	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
459424001500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424001501	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
459424001502	nucleotide binding site [chemical binding]; other site
459424001503	acyl-CoA synthetase; Validated; Region: PRK07788
459424001504	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424001505	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424001506	active site
459424001507	CoA binding site [chemical binding]; other site
459424001508	AMP binding site [chemical binding]; other site
459424001509	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424001510	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424001511	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424001512	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424001513	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
459424001514	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424001515	FAD binding site [chemical binding]; other site
459424001516	substrate binding site [chemical binding]; other site
459424001517	catalytic base [active]
459424001518	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
459424001519	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175
459424001520	putative ligand binding site [chemical binding]; other site
459424001521	putative NAD binding site [chemical binding]; other site
459424001522	catalytic site [active]
459424001523	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001524	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001525	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
459424001526	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424001527	Zn binding site [ion binding]; other site
459424001528	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001529	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
459424001530	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424001531	PPE family; Region: PPE; pfam00823
459424001532	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424001533	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424001534	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
459424001535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424001536	Walker A motif; other site
459424001537	ATP binding site [chemical binding]; other site
459424001538	Walker B motif; other site
459424001539	arginine finger; other site
459424001540	Protein of unknown function (DUF690); Region: DUF690; pfam05108
459424001541	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
459424001542	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424001543	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
459424001544	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424001545	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424001546	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424001547	PPE family; Region: PPE; pfam00823
459424001548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
459424001549	EspG family; Region: ESX-1_EspG; pfam14011
459424001550	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
459424001551	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
459424001552	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
459424001553	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
459424001554	active site
459424001555	catalytic residues [active]
459424001556	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
459424001557	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424001558	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
459424001559	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
459424001560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424001561	S-adenosylmethionine binding site [chemical binding]; other site
459424001562	Sulfatase; Region: Sulfatase; pfam00884
459424001563	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
459424001564	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
459424001565	putative FMN binding site [chemical binding]; other site
459424001566	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
459424001567	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
459424001568	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
459424001569	active site
459424001570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
459424001571	SnoaL-like domain; Region: SnoaL_4; pfam13577
459424001572	SnoaL-like domain; Region: SnoaL_3; pfam13474
459424001573	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
459424001574	nucleotide binding site [chemical binding]; other site
459424001575	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
459424001576	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
459424001577	Prostaglandin dehydrogenases; Region: PGDH; cd05288
459424001578	NAD(P) binding site [chemical binding]; other site
459424001579	substrate binding site [chemical binding]; other site
459424001580	dimer interface [polypeptide binding]; other site
459424001581	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001582	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001583	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001584	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
459424001585	active site
459424001586	catalytic residues [active]
459424001587	Muconolactone delta-isomerase; Region: MIase; cl01992
459424001588	Muconolactone delta-isomerase; Region: MIase; cl01992
459424001589	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
459424001590	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
459424001591	active site
459424001592	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
459424001593	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
459424001594	nucleotide binding site [chemical binding]; other site
459424001595	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
459424001596	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
459424001597	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
459424001598	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
459424001599	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424001600	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
459424001601	dinuclear metal binding motif [ion binding]; other site
459424001602	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424001603	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424001604	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424001605	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424001606	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424001607	substrate binding pocket [chemical binding]; other site
459424001608	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001609	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001610	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001611	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001612	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001613	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001614	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001615	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001616	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001617	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
459424001618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424001619	putative substrate translocation pore; other site
459424001620	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
459424001621	putative substrate binding pocket [chemical binding]; other site
459424001622	AC domain interface; other site
459424001623	catalytic triad [active]
459424001624	AB domain interface; other site
459424001625	interchain disulfide; other site
459424001626	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
459424001627	trimer interface [polypeptide binding]; other site
459424001628	active site
459424001629	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
459424001630	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
459424001631	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
459424001632	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
459424001633	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
459424001634	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424001635	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
459424001636	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
459424001637	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
459424001638	substrate binding site; other site
459424001639	tetramer interface; other site
459424001640	PE family; Region: PE; pfam00934
459424001641	PE family; Region: PE; pfam00934
459424001642	PE family; Region: PE; pfam00934
459424001643	aminotransferase AlaT; Validated; Region: PRK09265
459424001644	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424001645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424001646	homodimer interface [polypeptide binding]; other site
459424001647	catalytic residue [active]
459424001648	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
459424001649	4Fe-4S binding domain; Region: Fer4; pfam00037
459424001650	Cysteine-rich domain; Region: CCG; pfam02754
459424001651	Cysteine-rich domain; Region: CCG; pfam02754
459424001652	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
459424001653	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
459424001654	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424001655	catalytic loop [active]
459424001656	iron binding site [ion binding]; other site
459424001657	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
459424001658	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
459424001659	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
459424001660	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
459424001661	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
459424001662	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
459424001663	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
459424001664	PE family; Region: PE; pfam00934
459424001665	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
459424001666	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
459424001667	nucleotide binding site [chemical binding]; other site
459424001668	NEF interaction site [polypeptide binding]; other site
459424001669	SBD interface [polypeptide binding]; other site
459424001670	GrpE; Region: GrpE; pfam01025
459424001671	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
459424001672	dimer interface [polypeptide binding]; other site
459424001673	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
459424001674	chaperone protein DnaJ; Provisional; Region: PRK14279
459424001675	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
459424001676	HSP70 interaction site [polypeptide binding]; other site
459424001677	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
459424001678	Zn binding sites [ion binding]; other site
459424001679	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
459424001680	dimer interface [polypeptide binding]; other site
459424001681	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
459424001682	DNA binding residues [nucleotide binding]
459424001683	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
459424001684	putative dimer interface [polypeptide binding]; other site
459424001685	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001686	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001687	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001688	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
459424001689	active site
459424001690	catalytic residues [active]
459424001691	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
459424001692	heme-binding site [chemical binding]; other site
459424001693	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
459424001694	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
459424001695	FAD binding pocket [chemical binding]; other site
459424001696	FAD binding motif [chemical binding]; other site
459424001697	phosphate binding motif [ion binding]; other site
459424001698	beta-alpha-beta structure motif; other site
459424001699	NAD binding pocket [chemical binding]; other site
459424001700	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
459424001701	Clp amino terminal domain; Region: Clp_N; pfam02861
459424001702	Clp amino terminal domain; Region: Clp_N; pfam02861
459424001703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424001704	Walker A motif; other site
459424001705	ATP binding site [chemical binding]; other site
459424001706	Walker B motif; other site
459424001707	arginine finger; other site
459424001708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424001709	Walker A motif; other site
459424001710	ATP binding site [chemical binding]; other site
459424001711	Walker B motif; other site
459424001712	arginine finger; other site
459424001713	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
459424001714	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424001715	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424001716	substrate binding site [chemical binding]; other site
459424001717	oxyanion hole (OAH) forming residues; other site
459424001718	trimer interface [polypeptide binding]; other site
459424001719	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
459424001720	classical (c) SDRs; Region: SDR_c; cd05233
459424001721	NAD(P) binding site [chemical binding]; other site
459424001722	active site
459424001723	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
459424001724	active site
459424001725	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
459424001726	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
459424001727	Uncharacterized conserved protein [Function unknown]; Region: COG3360
459424001728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
459424001729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
459424001730	LysR substrate binding domain; Region: LysR_substrate; pfam03466
459424001731	dimerization interface [polypeptide binding]; other site
459424001732	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
459424001733	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
459424001734	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
459424001735	XdhC Rossmann domain; Region: XdhC_C; pfam13478
459424001736	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
459424001737	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
459424001738	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
459424001739	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424001740	catalytic loop [active]
459424001741	iron binding site [ion binding]; other site
459424001742	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
459424001743	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
459424001744	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
459424001745	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
459424001746	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
459424001747	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
459424001748	XdhC Rossmann domain; Region: XdhC_C; pfam13478
459424001749	metallochaperone-like domain; Region: TRASH; smart00746
459424001750	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
459424001751	Ligand binding site; other site
459424001752	metal-binding site
459424001753	MoxR-like ATPases [General function prediction only]; Region: COG0714
459424001754	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
459424001755	putative hydrophobic ligand binding site [chemical binding]; other site
459424001756	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
459424001757	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
459424001758	metal ion-dependent adhesion site (MIDAS); other site
459424001759	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
459424001760	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
459424001761	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
459424001762	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
459424001763	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
459424001764	active site
459424001765	intersubunit interface [polypeptide binding]; other site
459424001766	zinc binding site [ion binding]; other site
459424001767	Na+ binding site [ion binding]; other site
459424001768	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
459424001769	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
459424001770	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
459424001771	Heme NO binding associated; Region: HNOBA; pfam07701
459424001772	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
459424001773	cyclase homology domain; Region: CHD; cd07302
459424001774	nucleotidyl binding site; other site
459424001775	metal binding site [ion binding]; metal-binding site
459424001776	dimer interface [polypeptide binding]; other site
459424001777	MgtE intracellular N domain; Region: MgtE_N; cl15244
459424001778	FOG: CBS domain [General function prediction only]; Region: COG0517
459424001779	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
459424001780	Divalent cation transporter; Region: MgtE; cl00786
459424001781	Divalent cation transporter; Region: MgtE; cl00786
459424001782	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001783	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001784	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424001785	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
459424001786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424001787	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
459424001788	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
459424001789	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
459424001790	Peptidase family M50; Region: Peptidase_M50; pfam02163
459424001791	active site
459424001792	putative substrate binding region [chemical binding]; other site
459424001793	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
459424001794	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
459424001795	GDP-binding site [chemical binding]; other site
459424001796	ACT binding site; other site
459424001797	IMP binding site; other site
459424001798	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
459424001799	CoenzymeA binding site [chemical binding]; other site
459424001800	subunit interaction site [polypeptide binding]; other site
459424001801	PHB binding site; other site
459424001802	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
459424001803	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424001804	substrate binding pocket [chemical binding]; other site
459424001805	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001806	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001807	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001808	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001809	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001810	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001811	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424001812	PPE family; Region: PPE; pfam00823
459424001813	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
459424001814	active site residue [active]
459424001815	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
459424001816	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
459424001817	homodimer interface [polypeptide binding]; other site
459424001818	substrate-cofactor binding pocket; other site
459424001819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424001820	catalytic residue [active]
459424001821	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
459424001822	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424001823	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424001824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424001825	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
459424001826	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
459424001827	Protein of unknown function (DUF971); Region: DUF971; cl01414
459424001828	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
459424001829	substrate binding pocket [chemical binding]; other site
459424001830	active site
459424001831	iron coordination sites [ion binding]; other site
459424001832	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
459424001833	tetramerization interface [polypeptide binding]; other site
459424001834	active site
459424001835	Methyltransferase domain; Region: Methyltransf_31; pfam13847
459424001836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424001837	S-adenosylmethionine binding site [chemical binding]; other site
459424001838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424001839	S-adenosylmethionine binding site [chemical binding]; other site
459424001840	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424001841	Beta-lactamase; Region: Beta-lactamase; pfam00144
459424001842	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424001843	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424001844	active site
459424001845	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
459424001846	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424001847	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
459424001848	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
459424001849	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
459424001850	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
459424001851	active site
459424001852	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
459424001853	non-prolyl cis peptide bond; other site
459424001854	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
459424001855	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424001856	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424001857	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
459424001858	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
459424001859	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
459424001860	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424001861	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
459424001862	propionate/acetate kinase; Provisional; Region: PRK12379
459424001863	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
459424001864	putative active site [active]
459424001865	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424001866	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424001867	active site
459424001868	ATP binding site [chemical binding]; other site
459424001869	substrate binding site [chemical binding]; other site
459424001870	activation loop (A-loop); other site
459424001871	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
459424001872	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
459424001873	substrate binding pocket [chemical binding]; other site
459424001874	membrane-bound complex binding site; other site
459424001875	hinge residues; other site
459424001876	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
459424001877	nudix motif; other site
459424001878	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
459424001879	thiamine phosphate binding site [chemical binding]; other site
459424001880	active site
459424001881	pyrophosphate binding site [ion binding]; other site
459424001882	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424001883	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
459424001884	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
459424001885	thiS-thiF/thiG interaction site; other site
459424001886	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
459424001887	ThiS interaction site; other site
459424001888	putative active site [active]
459424001889	tetramer interface [polypeptide binding]; other site
459424001890	Interferon-induced transmembrane protein; Region: CD225; pfam04505
459424001891	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
459424001892	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
459424001893	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
459424001894	PA/protease or protease-like domain interface [polypeptide binding]; other site
459424001895	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
459424001896	Peptidase family M28; Region: Peptidase_M28; pfam04389
459424001897	active site
459424001898	metal binding site [ion binding]; metal-binding site
459424001899	Predicted metalloprotease [General function prediction only]; Region: COG2321
459424001900	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
459424001901	Response regulator receiver domain; Region: Response_reg; pfam00072
459424001902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424001903	active site
459424001904	phosphorylation site [posttranslational modification]
459424001905	intermolecular recognition site; other site
459424001906	dimerization interface [polypeptide binding]; other site
459424001907	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424001908	cyclase homology domain; Region: CHD; cd07302
459424001909	nucleotidyl binding site; other site
459424001910	metal binding site [ion binding]; metal-binding site
459424001911	dimer interface [polypeptide binding]; other site
459424001912	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
459424001913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001914	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001915	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424001916	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424001917	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
459424001918	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
459424001919	dimer interface [polypeptide binding]; other site
459424001920	substrate binding site [chemical binding]; other site
459424001921	ATP binding site [chemical binding]; other site
459424001922	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
459424001923	ThiC-associated domain; Region: ThiC-associated; pfam13667
459424001924	ThiC family; Region: ThiC; pfam01964
459424001925	PAS fold; Region: PAS_3; pfam08447
459424001926	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
459424001927	putative active site [active]
459424001928	heme pocket [chemical binding]; other site
459424001929	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
459424001930	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
459424001931	anti sigma factor interaction site; other site
459424001932	regulatory phosphorylation site [posttranslational modification]; other site
459424001933	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
459424001934	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
459424001935	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424001936	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424001937	motif II; other site
459424001938	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
459424001939	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
459424001940	putative catalytic site [active]
459424001941	putative phosphate binding site [ion binding]; other site
459424001942	active site
459424001943	metal binding site A [ion binding]; metal-binding site
459424001944	DNA binding site [nucleotide binding]
459424001945	putative AP binding site [nucleotide binding]; other site
459424001946	putative metal binding site B [ion binding]; other site
459424001947	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
459424001948	active site
459424001949	catalytic residues [active]
459424001950	metal binding site [ion binding]; metal-binding site
459424001951	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
459424001952	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
459424001953	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
459424001954	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
459424001955	E-class dimer interface [polypeptide binding]; other site
459424001956	P-class dimer interface [polypeptide binding]; other site
459424001957	active site
459424001958	Cu2+ binding site [ion binding]; other site
459424001959	Zn2+ binding site [ion binding]; other site
459424001960	carboxylate-amine ligase; Provisional; Region: PRK13517
459424001961	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
459424001962	Transcriptional regulators [Transcription]; Region: FadR; COG2186
459424001963	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424001964	DNA-binding site [nucleotide binding]; DNA binding site
459424001965	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
459424001966	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
459424001967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424001968	putative substrate translocation pore; other site
459424001969	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
459424001970	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
459424001971	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
459424001972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424001973	Walker A motif; other site
459424001974	ATP binding site [chemical binding]; other site
459424001975	Walker B motif; other site
459424001976	arginine finger; other site
459424001977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424001978	Walker A motif; other site
459424001979	ATP binding site [chemical binding]; other site
459424001980	Walker B motif; other site
459424001981	arginine finger; other site
459424001982	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
459424001983	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
459424001984	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
459424001985	PE family; Region: PE; pfam00934
459424001986	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
459424001987	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
459424001988	dimer interface [polypeptide binding]; other site
459424001989	putative functional site; other site
459424001990	putative MPT binding site; other site
459424001991	short chain dehydrogenase; Provisional; Region: PRK06197
459424001992	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
459424001993	putative NAD(P) binding site [chemical binding]; other site
459424001994	active site
459424001995	Cupin domain; Region: Cupin_2; pfam07883
459424001996	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
459424001997	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
459424001998	ring oligomerisation interface [polypeptide binding]; other site
459424001999	ATP/Mg binding site [chemical binding]; other site
459424002000	stacking interactions; other site
459424002001	hinge regions; other site
459424002002	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424002003	PPE family; Region: PPE; pfam00823
459424002004	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
459424002005	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
459424002006	active site
459424002007	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424002008	Protein of unknown function (DUF664); Region: DUF664; pfam04978
459424002009	DinB superfamily; Region: DinB_2; pfam12867
459424002010	Anti-sigma-K factor rskA; Region: RskA; pfam10099
459424002011	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
459424002012	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424002013	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424002014	DNA binding residues [nucleotide binding]
459424002015	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
459424002016	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424002017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002018	S-adenosylmethionine binding site [chemical binding]; other site
459424002019	Protein of unknown function (DUF1365); Region: DUF1365; cl17838
459424002020	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
459424002021	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424002022	Transport protein; Region: actII; TIGR00833
459424002023	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424002024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424002025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424002026	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424002027	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
459424002028	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002029	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002030	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002031	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
459424002032	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424002033	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002034	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002035	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002036	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
459424002037	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
459424002038	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424002039	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
459424002040	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002042	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002043	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002044	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002045	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002046	Protein of unknown function (DUF779); Region: DUF779; pfam05610
459424002047	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002048	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002049	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002050	Uncharacterized conserved protein [Function unknown]; Region: COG2128
459424002051	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
459424002052	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
459424002053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424002054	non-specific DNA binding site [nucleotide binding]; other site
459424002055	salt bridge; other site
459424002056	sequence-specific DNA binding site [nucleotide binding]; other site
459424002057	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
459424002058	Domain of unknown function (DUF955); Region: DUF955; pfam06114
459424002059	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
459424002060	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
459424002061	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424002062	active site 2 [active]
459424002063	active site 1 [active]
459424002064	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424002065	active site 2 [active]
459424002066	isocitrate lyase; Provisional; Region: PRK15063
459424002067	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
459424002068	tetramer interface [polypeptide binding]; other site
459424002069	active site
459424002070	Mg2+/Mn2+ binding site [ion binding]; other site
459424002071	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
459424002072	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
459424002073	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
459424002074	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424002075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424002076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002077	S-adenosylmethionine binding site [chemical binding]; other site
459424002078	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424002079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002080	S-adenosylmethionine binding site [chemical binding]; other site
459424002081	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424002082	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424002083	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
459424002084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424002085	non-specific DNA binding site [nucleotide binding]; other site
459424002086	salt bridge; other site
459424002087	sequence-specific DNA binding site [nucleotide binding]; other site
459424002088	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
459424002089	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
459424002090	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
459424002091	intersubunit interface [polypeptide binding]; other site
459424002092	active site
459424002093	catalytic residue [active]
459424002094	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
459424002095	Predicted amidohydrolase [General function prediction only]; Region: COG0388
459424002096	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
459424002097	putative active site [active]
459424002098	catalytic triad [active]
459424002099	putative dimer interface [polypeptide binding]; other site
459424002100	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
459424002101	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
459424002102	FAD binding domain; Region: FAD_binding_4; pfam01565
459424002103	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
459424002104	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
459424002105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
459424002106	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
459424002107	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
459424002108	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
459424002109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424002110	NAD(P) binding site [chemical binding]; other site
459424002111	active site
459424002112	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
459424002113	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
459424002114	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
459424002115	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
459424002116	putative ADP-binding pocket [chemical binding]; other site
459424002117	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
459424002118	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424002119	catalytic core [active]
459424002120	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424002121	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
459424002122	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
459424002123	dimer interface [polypeptide binding]; other site
459424002124	phosphorylation site [posttranslational modification]
459424002125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424002126	ATP binding site [chemical binding]; other site
459424002127	Mg2+ binding site [ion binding]; other site
459424002128	G-X-G motif; other site
459424002129	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424002130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424002131	active site
459424002132	phosphorylation site [posttranslational modification]
459424002133	intermolecular recognition site; other site
459424002134	dimerization interface [polypeptide binding]; other site
459424002135	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424002136	DNA binding site [nucleotide binding]
459424002137	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
459424002138	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
459424002139	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
459424002140	Transcriptional regulators [Transcription]; Region: FadR; COG2186
459424002141	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424002142	DNA-binding site [nucleotide binding]; DNA binding site
459424002143	FCD domain; Region: FCD; cl11656
459424002144	exopolyphosphatase; Region: exo_poly_only; TIGR03706
459424002145	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
459424002146	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
459424002147	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
459424002148	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
459424002149	Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046
459424002150	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
459424002151	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
459424002152	DNA binding domain, excisionase family; Region: excise; TIGR01764
459424002153	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424002154	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
459424002155	putative NAD(P) binding site [chemical binding]; other site
459424002156	active site
459424002157	putative substrate binding site [chemical binding]; other site
459424002158	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424002159	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
459424002160	putative acyl-acceptor binding pocket; other site
459424002161	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424002162	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424002163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002164	S-adenosylmethionine binding site [chemical binding]; other site
459424002165	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
459424002166	active site
459424002167	catalytic site [active]
459424002168	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
459424002169	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
459424002170	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424002171	active site
459424002172	motif I; other site
459424002173	motif II; other site
459424002174	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
459424002175	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424002176	catalytic loop [active]
459424002177	iron binding site [ion binding]; other site
459424002178	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
459424002179	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
459424002180	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
459424002181	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
459424002182	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
459424002183	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
459424002184	PE family; Region: PE; pfam00934
459424002185	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424002186	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002187	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002188	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002189	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
459424002190	dimer interface [polypeptide binding]; other site
459424002191	active site
459424002192	Schiff base residues; other site
459424002193	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
459424002194	active site
459424002195	homodimer interface [polypeptide binding]; other site
459424002196	SAM binding site [chemical binding]; other site
459424002197	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
459424002198	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
459424002199	active site
459424002200	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
459424002201	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
459424002202	domain interfaces; other site
459424002203	active site
459424002204	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
459424002205	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
459424002206	tRNA; other site
459424002207	putative tRNA binding site [nucleotide binding]; other site
459424002208	putative NADP binding site [chemical binding]; other site
459424002209	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
459424002210	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
459424002211	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
459424002212	anti sigma factor interaction site; other site
459424002213	regulatory phosphorylation site [posttranslational modification]; other site
459424002214	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
459424002215	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
459424002216	active site
459424002217	catalytic triad [active]
459424002218	oxyanion hole [active]
459424002219	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
459424002220	Putative esterase; Region: Esterase; pfam00756
459424002221	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424002222	Ligand Binding Site [chemical binding]; other site
459424002223	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
459424002224	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
459424002225	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424002226	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
459424002227	Soluble P-type ATPase [General function prediction only]; Region: COG4087
459424002228	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
459424002229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002230	S-adenosylmethionine binding site [chemical binding]; other site
459424002231	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424002232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002233	S-adenosylmethionine binding site [chemical binding]; other site
459424002234	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
459424002235	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
459424002236	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
459424002237	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
459424002238	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
459424002239	metal binding site [ion binding]; metal-binding site
459424002240	substrate binding pocket [chemical binding]; other site
459424002241	Domain of unknown function (DUF427); Region: DUF427; pfam04248
459424002242	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
459424002243	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424002244	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424002245	active site
459424002246	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
459424002247	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424002248	inhibitor-cofactor binding pocket; inhibition site
459424002249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424002250	catalytic residue [active]
459424002251	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
459424002252	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
459424002253	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
459424002254	catalytic residues [active]
459424002255	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
459424002256	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
459424002257	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
459424002258	ResB-like family; Region: ResB; pfam05140
459424002259	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
459424002260	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
459424002261	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
459424002262	P-loop; other site
459424002263	Magnesium ion binding site [ion binding]; other site
459424002264	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
459424002265	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
459424002266	dimer interface [polypeptide binding]; other site
459424002267	active site
459424002268	CoA binding pocket [chemical binding]; other site
459424002269	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
459424002270	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
459424002271	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424002272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424002273	NAD(P) binding site [chemical binding]; other site
459424002274	active site
459424002275	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
459424002276	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
459424002277	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424002278	acyl-activating enzyme (AAE) consensus motif; other site
459424002279	AMP binding site [chemical binding]; other site
459424002280	active site
459424002281	CoA binding site [chemical binding]; other site
459424002282	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
459424002283	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
459424002284	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424002285	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
459424002286	active site
459424002287	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424002288	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
459424002289	short chain dehydrogenase; Provisional; Region: PRK05866
459424002290	classical (c) SDRs; Region: SDR_c; cd05233
459424002291	NAD(P) binding site [chemical binding]; other site
459424002292	active site
459424002293	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424002294	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
459424002295	substrate binding site [chemical binding]; other site
459424002296	oxyanion hole (OAH) forming residues; other site
459424002297	trimer interface [polypeptide binding]; other site
459424002298	acyl-CoA synthetase; Validated; Region: PRK06188
459424002299	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424002300	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
459424002301	putative active site [active]
459424002302	putative CoA binding site [chemical binding]; other site
459424002303	putative AMP binding site [chemical binding]; other site
459424002304	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
459424002305	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
459424002306	active site
459424002307	O-succinylbenzoate synthase; Provisional; Region: PRK02901
459424002308	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
459424002309	active site
459424002310	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424002311	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424002312	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
459424002313	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424002314	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
459424002315	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424002316	MarR family; Region: MarR; pfam01047
459424002317	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
459424002318	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002319	S-adenosylmethionine binding site [chemical binding]; other site
459424002320	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424002321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424002322	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
459424002323	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424002324	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
459424002325	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
459424002326	substrate binding pocket [chemical binding]; other site
459424002327	chain length determination region; other site
459424002328	substrate-Mg2+ binding site; other site
459424002329	catalytic residues [active]
459424002330	aspartate-rich region 1; other site
459424002331	active site lid residues [active]
459424002332	aspartate-rich region 2; other site
459424002333	heat shock protein HtpX; Provisional; Region: PRK03072
459424002334	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
459424002335	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
459424002336	Sulfate transporter family; Region: Sulfate_transp; pfam00916
459424002337	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
459424002338	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
459424002339	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
459424002340	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
459424002341	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
459424002342	TPR repeat; Region: TPR_11; pfam13414
459424002343	Tetratricopeptide repeat; Region: TPR_2; pfam07719
459424002344	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
459424002345	Double zinc ribbon; Region: DZR; pfam12773
459424002346	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424002347	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424002348	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
459424002349	Domain of unknown function (DUF4135); Region: DUF4135; pfam13575
459424002350	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
459424002351	active site
459424002352	zinc binding site [ion binding]; other site
459424002353	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
459424002354	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
459424002355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
459424002356	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
459424002357	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
459424002358	FtsX-like permease family; Region: FtsX; pfam02687
459424002359	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
459424002360	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
459424002361	Walker A/P-loop; other site
459424002362	ATP binding site [chemical binding]; other site
459424002363	Q-loop/lid; other site
459424002364	ABC transporter signature motif; other site
459424002365	Walker B; other site
459424002366	D-loop; other site
459424002367	H-loop/switch region; other site
459424002368	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424002369	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424002370	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
459424002371	classical (c) SDRs; Region: SDR_c; cd05233
459424002372	NAD(P) binding site [chemical binding]; other site
459424002373	active site
459424002374	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
459424002375	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424002376	PPE family; Region: PPE; pfam00823
459424002377	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424002378	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
459424002379	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002380	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002381	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002382	MULiRD3
459424002383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424002384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424002385	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
459424002386	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
459424002387	DNA binding site [nucleotide binding]
459424002388	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002389	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002390	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002391	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
459424002392	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
459424002393	putative Mg++ binding site [ion binding]; other site
459424002394	helicase superfamily c-terminal domain; Region: HELICc; smart00490
459424002395	Helicase associated domain; Region: HA; pfam03457
459424002396	Helicase associated domain; Region: HA; pfam03457
459424002397	Helicase associated domain; Region: HA; pfam03457
459424002398	Helicase associated domain; Region: HA; pfam03457
459424002399	Helicase associated domain; Region: HA; pfam03457
459424002400	Helicase associated domain; Region: HA; pfam03457
459424002401	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
459424002402	putative active site [active]
459424002403	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
459424002404	oligomeric interface; other site
459424002405	putative active site [active]
459424002406	homodimer interface [polypeptide binding]; other site
459424002407	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
459424002408	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
459424002409	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
459424002410	sequence-specific DNA binding site [nucleotide binding]; other site
459424002411	salt bridge; other site
459424002412	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
459424002413	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
459424002414	active site
459424002415	DNA binding site [nucleotide binding]
459424002416	Int/Topo IB signature motif; other site
459424002417	malonyl-CoA synthase; Validated; Region: PRK07514
459424002418	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
459424002419	acyl-activating enzyme (AAE) consensus motif; other site
459424002420	active site
459424002421	AMP binding site [chemical binding]; other site
459424002422	CoA binding site [chemical binding]; other site
459424002423	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
459424002424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424002425	metabolite-proton symporter; Region: 2A0106; TIGR00883
459424002426	putative substrate translocation pore; other site
459424002427	Predicted amidohydrolase [General function prediction only]; Region: COG0388
459424002428	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
459424002429	putative active site [active]
459424002430	catalytic triad [active]
459424002431	putative dimer interface [polypeptide binding]; other site
459424002432	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
459424002433	Predicted amidohydrolase [General function prediction only]; Region: COG0388
459424002434	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
459424002435	active site
459424002436	catalytic triad [active]
459424002437	dimer interface [polypeptide binding]; other site
459424002438	Cupin domain; Region: Cupin_2; cl17218
459424002439	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
459424002440	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
459424002441	tetramer interface [polypeptide binding]; other site
459424002442	heme binding pocket [chemical binding]; other site
459424002443	NADPH binding site [chemical binding]; other site
459424002444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002445	S-adenosylmethionine binding site [chemical binding]; other site
459424002446	Helix-turn-helix domain; Region: HTH_18; pfam12833
459424002447	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
459424002448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424002449	non-specific DNA binding site [nucleotide binding]; other site
459424002450	salt bridge; other site
459424002451	sequence-specific DNA binding site [nucleotide binding]; other site
459424002452	Cupin domain; Region: Cupin_2; pfam07883
459424002453	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
459424002454	intersubunit interface [polypeptide binding]; other site
459424002455	active site
459424002456	Zn2+ binding site [ion binding]; other site
459424002457	dihydrodipicolinate synthase; Region: dapA; TIGR00674
459424002458	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
459424002459	inhibitor site; inhibition site
459424002460	active site
459424002461	dimer interface [polypeptide binding]; other site
459424002462	catalytic residue [active]
459424002463	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002464	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002465	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002466	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
459424002467	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
459424002468	dimer interface [polypeptide binding]; other site
459424002469	decamer (pentamer of dimers) interface [polypeptide binding]; other site
459424002470	catalytic triad [active]
459424002471	peroxidatic and resolving cysteines [active]
459424002472	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
459424002473	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424002474	active site
459424002475	metal binding site [ion binding]; metal-binding site
459424002476	L-lactate permease; Region: Lactate_perm; cl00701
459424002477	Domain of unknown function (DUF309); Region: DUF309; pfam03745
459424002478	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
459424002479	FMN binding site [chemical binding]; other site
459424002480	substrate binding site [chemical binding]; other site
459424002481	putative catalytic residue [active]
459424002482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002483	S-adenosylmethionine binding site [chemical binding]; other site
459424002484	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
459424002485	Cupin domain; Region: Cupin_2; cl17218
459424002486	Predicted transcriptional regulator [Transcription]; Region: COG2345
459424002487	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424002488	putative DNA binding site [nucleotide binding]; other site
459424002489	putative Zn2+ binding site [ion binding]; other site
459424002490	Predicted permease [General function prediction only]; Region: COG3329
459424002491	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424002492	MarR family; Region: MarR; pfam01047
459424002493	Uncharacterized conserved protein [Function unknown]; Region: COG3189
459424002494	Predicted transcriptional regulator [Transcription]; Region: COG2345
459424002495	Hemerythrin-like domain; Region: Hr-like; cd12108
459424002496	Fe binding site [ion binding]; other site
459424002497	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
459424002498	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
459424002499	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
459424002500	Hemerythrin-like domain; Region: Hr-like; cd12108
459424002501	Fe binding site [ion binding]; other site
459424002502	OsmC-like protein; Region: OsmC; cl00767
459424002503	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
459424002504	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
459424002505	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
459424002506	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
459424002507	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
459424002508	Binuclear center (active site) [active]
459424002509	K-pathway; other site
459424002510	Putative proton exit pathway; other site
459424002511	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424002512	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
459424002513	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424002514	FMN binding site [chemical binding]; other site
459424002515	dimer interface [polypeptide binding]; other site
459424002516	Predicted transcriptional regulator [Transcription]; Region: COG2345
459424002517	HTH domain; Region: HTH_11; pfam08279
459424002518	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
459424002519	heme-binding site [chemical binding]; other site
459424002520	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002521	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002522	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002523	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
459424002524	Cupin domain; Region: Cupin_2; cl17218
459424002525	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002526	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002527	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002528	O-methyltransferase; Region: Methyltransf_2; pfam00891
459424002529	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424002530	cyclase homology domain; Region: CHD; cd07302
459424002531	nucleotidyl binding site; other site
459424002532	metal binding site [ion binding]; metal-binding site
459424002533	dimer interface [polypeptide binding]; other site
459424002534	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
459424002535	Sulfatase; Region: Sulfatase; pfam00884
459424002536	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
459424002537	amidase; Provisional; Region: PRK08137
459424002538	Amidase; Region: Amidase; cl11426
459424002539	hypothetical protein; Provisional; Region: PRK07588
459424002540	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424002541	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
459424002542	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
459424002543	dimer interface [polypeptide binding]; other site
459424002544	active site
459424002545	galactokinase; Provisional; Region: PRK00555
459424002546	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
459424002547	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
459424002548	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
459424002549	putative hydrophobic ligand binding site [chemical binding]; other site
459424002550	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424002551	TIGR03086 family protein; Region: TIGR03086
459424002552	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
459424002553	Uncharacterized conserved protein [Function unknown]; Region: COG1656
459424002554	Protein of unknown function DUF82; Region: DUF82; pfam01927
459424002555	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424002556	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424002557	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424002558	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
459424002559	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
459424002560	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
459424002561	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
459424002562	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
459424002563	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
459424002564	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
459424002565	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
459424002566	Amidohydrolase; Region: Amidohydro_4; pfam13147
459424002567	active site
459424002568	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424002569	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424002570	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
459424002571	AAA domain; Region: AAA_30; pfam13604
459424002572	Family description; Region: UvrD_C_2; pfam13538
459424002573	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
459424002574	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
459424002575	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
459424002576	putative FMN binding site [chemical binding]; other site
459424002577	cyanate hydratase; Validated; Region: PRK02866
459424002578	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
459424002579	oligomer interface [polypeptide binding]; other site
459424002580	active site
459424002581	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
459424002582	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
459424002583	active site
459424002584	nucleophile elbow; other site
459424002585	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
459424002586	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424002587	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424002588	substrate binding site [chemical binding]; other site
459424002589	oxyanion hole (OAH) forming residues; other site
459424002590	trimer interface [polypeptide binding]; other site
459424002591	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
459424002592	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
459424002593	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
459424002594	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
459424002595	active site
459424002596	catalytic site [active]
459424002597	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
459424002598	active site
459424002599	catalytic site [active]
459424002600	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
459424002601	active site
459424002602	catalytic site [active]
459424002603	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
459424002604	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
459424002605	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
459424002606	putative homodimer interface [polypeptide binding]; other site
459424002607	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
459424002608	heterodimer interface [polypeptide binding]; other site
459424002609	homodimer interface [polypeptide binding]; other site
459424002610	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
459424002611	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
459424002612	23S rRNA interface [nucleotide binding]; other site
459424002613	L7/L12 interface [polypeptide binding]; other site
459424002614	putative thiostrepton binding site; other site
459424002615	L25 interface [polypeptide binding]; other site
459424002616	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
459424002617	mRNA/rRNA interface [nucleotide binding]; other site
459424002618	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
459424002619	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
459424002620	DNA binding residues [nucleotide binding]
459424002621	YCII-related domain; Region: YCII; cl00999
459424002622	YCII-related domain; Region: YCII; cl00999
459424002623	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424002624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002625	S-adenosylmethionine binding site [chemical binding]; other site
459424002626	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424002627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424002628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002629	S-adenosylmethionine binding site [chemical binding]; other site
459424002630	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424002631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424002632	S-adenosylmethionine binding site [chemical binding]; other site
459424002633	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424002634	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
459424002635	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
459424002636	active site
459424002637	ATP binding site [chemical binding]; other site
459424002638	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
459424002639	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424002640	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
459424002641	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424002642	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
459424002643	Amidase; Region: Amidase; pfam01425
459424002644	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
459424002645	active site
459424002646	catalytic site [active]
459424002647	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
459424002648	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
459424002649	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
459424002650	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
459424002651	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
459424002652	nucleotide binding site [chemical binding]; other site
459424002653	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
459424002654	23S rRNA interface [nucleotide binding]; other site
459424002655	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
459424002656	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
459424002657	core dimer interface [polypeptide binding]; other site
459424002658	peripheral dimer interface [polypeptide binding]; other site
459424002659	L10 interface [polypeptide binding]; other site
459424002660	L11 interface [polypeptide binding]; other site
459424002661	putative EF-Tu interaction site [polypeptide binding]; other site
459424002662	putative EF-G interaction site [polypeptide binding]; other site
459424002663	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424002664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424002665	WHG domain; Region: WHG; pfam13305
459424002666	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
459424002667	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
459424002668	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
459424002669	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
459424002670	Walker A/P-loop; other site
459424002671	ATP binding site [chemical binding]; other site
459424002672	Q-loop/lid; other site
459424002673	ABC transporter signature motif; other site
459424002674	Walker B; other site
459424002675	D-loop; other site
459424002676	H-loop/switch region; other site
459424002677	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
459424002678	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
459424002679	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
459424002680	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
459424002681	RPB10 interaction site [polypeptide binding]; other site
459424002682	RPB1 interaction site [polypeptide binding]; other site
459424002683	RPB11 interaction site [polypeptide binding]; other site
459424002684	RPB3 interaction site [polypeptide binding]; other site
459424002685	RPB12 interaction site [polypeptide binding]; other site
459424002686	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
459424002687	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
459424002688	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
459424002689	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
459424002690	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
459424002691	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
459424002692	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
459424002693	G-loop; other site
459424002694	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
459424002695	DNA binding site [nucleotide binding]
459424002696	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
459424002697	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002698	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002699	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002700	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
459424002701	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424002702	endonuclease IV; Provisional; Region: PRK01060
459424002703	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
459424002704	AP (apurinic/apyrimidinic) site pocket; other site
459424002705	DNA interaction; other site
459424002706	Metal-binding active site; metal-binding site
459424002707	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
459424002708	enoyl-CoA hydratase; Provisional; Region: PRK12478
459424002709	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424002710	substrate binding site [chemical binding]; other site
459424002711	oxyanion hole (OAH) forming residues; other site
459424002712	trimer interface [polypeptide binding]; other site
459424002713	PaaX-like protein; Region: PaaX; pfam07848
459424002714	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
459424002715	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424002716	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424002717	substrate binding site [chemical binding]; other site
459424002718	oxyanion hole (OAH) forming residues; other site
459424002719	trimer interface [polypeptide binding]; other site
459424002720	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
459424002721	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424002722	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
459424002723	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
459424002724	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424002725	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424002726	WHG domain; Region: WHG; pfam13305
459424002727	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
459424002728	S17 interaction site [polypeptide binding]; other site
459424002729	S8 interaction site; other site
459424002730	16S rRNA interaction site [nucleotide binding]; other site
459424002731	streptomycin interaction site [chemical binding]; other site
459424002732	23S rRNA interaction site [nucleotide binding]; other site
459424002733	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
459424002734	30S ribosomal protein S7; Validated; Region: PRK05302
459424002735	elongation factor G; Reviewed; Region: PRK00007
459424002736	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
459424002737	G1 box; other site
459424002738	putative GEF interaction site [polypeptide binding]; other site
459424002739	GTP/Mg2+ binding site [chemical binding]; other site
459424002740	Switch I region; other site
459424002741	G2 box; other site
459424002742	G3 box; other site
459424002743	Switch II region; other site
459424002744	G4 box; other site
459424002745	G5 box; other site
459424002746	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
459424002747	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
459424002748	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
459424002749	elongation factor Tu; Reviewed; Region: PRK00049
459424002750	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
459424002751	G1 box; other site
459424002752	GEF interaction site [polypeptide binding]; other site
459424002753	GTP/Mg2+ binding site [chemical binding]; other site
459424002754	Switch I region; other site
459424002755	G2 box; other site
459424002756	G3 box; other site
459424002757	Switch II region; other site
459424002758	G4 box; other site
459424002759	G5 box; other site
459424002760	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
459424002761	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
459424002762	Antibiotic Binding Site [chemical binding]; other site
459424002763	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
459424002764	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424002765	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
459424002766	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
459424002767	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424002768	mycofactocin precursor; Region: mycofactocin; TIGR03969
459424002769	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
459424002770	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
459424002771	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424002772	FeS/SAM binding site; other site
459424002773	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
459424002774	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
459424002775	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
459424002776	phosphate binding site [ion binding]; other site
459424002777	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
459424002778	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
459424002779	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
459424002780	Probable Catalytic site; other site
459424002781	metal-binding site
459424002782	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
459424002783	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
459424002784	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424002785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424002786	sequence-specific DNA binding site [nucleotide binding]; other site
459424002787	salt bridge; other site
459424002788	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424002789	PPE family; Region: PPE; pfam00823
459424002790	PE-PPE domain; Region: PE-PPE; pfam08237
459424002791	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002792	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002793	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002794	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424002795	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002796	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002797	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424002798	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424002799	Secretory lipase; Region: LIP; pfam03583
459424002800	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
459424002801	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
459424002802	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
459424002803	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
459424002804	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
459424002805	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
459424002806	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
459424002807	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
459424002808	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
459424002809	putative translocon binding site; other site
459424002810	protein-rRNA interface [nucleotide binding]; other site
459424002811	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
459424002812	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
459424002813	G-X-X-G motif; other site
459424002814	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
459424002815	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
459424002816	23S rRNA interface [nucleotide binding]; other site
459424002817	5S rRNA interface [nucleotide binding]; other site
459424002818	putative antibiotic binding site [chemical binding]; other site
459424002819	L25 interface [polypeptide binding]; other site
459424002820	L27 interface [polypeptide binding]; other site
459424002821	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
459424002822	L23 interface [polypeptide binding]; other site
459424002823	signal recognition particle (SRP54) interaction site; other site
459424002824	trigger factor interaction site; other site
459424002825	23S rRNA interface [nucleotide binding]; other site
459424002826	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
459424002827	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
459424002828	Sulfatase; Region: Sulfatase; pfam00884
459424002829	Laminin G domain; Region: LamG; smart00282
459424002830	Uncharacterized conserved protein [Function unknown]; Region: COG1262
459424002831	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
459424002832	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
459424002833	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
459424002834	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
459424002835	RNA binding site [nucleotide binding]; other site
459424002836	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
459424002837	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
459424002838	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
459424002839	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
459424002840	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
459424002841	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
459424002842	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
459424002843	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
459424002844	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
459424002845	5S rRNA interface [nucleotide binding]; other site
459424002846	23S rRNA interface [nucleotide binding]; other site
459424002847	L5 interface [polypeptide binding]; other site
459424002848	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
459424002849	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
459424002850	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
459424002851	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
459424002852	23S rRNA binding site [nucleotide binding]; other site
459424002853	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
459424002854	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
459424002855	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424002856	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424002857	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424002858	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424002859	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424002860	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424002861	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424002862	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
459424002863	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
459424002864	L-fuculose-phosphate aldolase; Validated; Region: PRK05874
459424002865	intersubunit interface [polypeptide binding]; other site
459424002866	active site
459424002867	Zn2+ binding site [ion binding]; other site
459424002868	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
459424002869	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
459424002870	putative ligand binding site [chemical binding]; other site
459424002871	putative NAD binding site [chemical binding]; other site
459424002872	catalytic site [active]
459424002873	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
459424002874	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
459424002875	nucleotide binding site [chemical binding]; other site
459424002876	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
459424002877	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424002878	Coenzyme A binding pocket [chemical binding]; other site
459424002879	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424002880	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424002881	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424002882	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424002883	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
459424002884	SecY translocase; Region: SecY; pfam00344
459424002885	adenylate kinase; Reviewed; Region: adk; PRK00279
459424002886	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
459424002887	AMP-binding site [chemical binding]; other site
459424002888	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
459424002889	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
459424002890	active site
459424002891	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
459424002892	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424002893	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424002894	DNA binding residues [nucleotide binding]
459424002895	Putative zinc-finger; Region: zf-HC2; pfam13490
459424002896	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424002897	MarR family; Region: MarR; pfam01047
459424002898	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424002899	TIGR03086 family protein; Region: TIGR03086
459424002900	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
459424002901	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
459424002902	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424002903	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
459424002904	substrate binding pocket [chemical binding]; other site
459424002905	FAD binding site [chemical binding]; other site
459424002906	catalytic base [active]
459424002907	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
459424002908	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
459424002909	tetrameric interface [polypeptide binding]; other site
459424002910	NAD binding site [chemical binding]; other site
459424002911	catalytic residues [active]
459424002912	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
459424002913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424002914	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
459424002915	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
459424002916	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
459424002917	NAD binding site [chemical binding]; other site
459424002918	substrate binding site [chemical binding]; other site
459424002919	homodimer interface [polypeptide binding]; other site
459424002920	active site
459424002921	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
459424002922	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
459424002923	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
459424002924	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
459424002925	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
459424002926	rRNA binding site [nucleotide binding]; other site
459424002927	predicted 30S ribosome binding site; other site
459424002928	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
459424002929	30S ribosomal protein S13; Region: bact_S13; TIGR03631
459424002930	30S ribosomal protein S11; Validated; Region: PRK05309
459424002931	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
459424002932	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
459424002933	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
459424002934	RNA binding surface [nucleotide binding]; other site
459424002935	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
459424002936	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
459424002937	alphaNTD homodimer interface [polypeptide binding]; other site
459424002938	alphaNTD - beta interaction site [polypeptide binding]; other site
459424002939	alphaNTD - beta' interaction site [polypeptide binding]; other site
459424002940	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
459424002941	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
459424002942	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
459424002943	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
459424002944	active site
459424002945	dimerization interface 3.5A [polypeptide binding]; other site
459424002946	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
459424002947	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424002948	PPE family; Region: PPE; pfam00823
459424002949	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424002950	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424002951	PPE family; Region: PPE; pfam00823
459424002952	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424002953	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
459424002954	Cutinase; Region: Cutinase; pfam01083
459424002955	Cutinase; Region: Cutinase; pfam01083
459424002956	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
459424002957	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
459424002958	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
459424002959	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
459424002960	active site
459424002961	catalytic residues [active]
459424002962	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
459424002963	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
459424002964	Proteins of 100 residues with WXG; Region: WXG100; cl02005
459424002965	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
459424002966	23S rRNA interface [nucleotide binding]; other site
459424002967	L3 interface [polypeptide binding]; other site
459424002968	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
459424002969	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
459424002970	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
459424002971	active site
459424002972	substrate binding site [chemical binding]; other site
459424002973	metal binding site [ion binding]; metal-binding site
459424002974	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
459424002975	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424002976	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
459424002977	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
459424002978	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
459424002979	glutaminase active site [active]
459424002980	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
459424002981	dimer interface [polypeptide binding]; other site
459424002982	active site
459424002983	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
459424002984	dimer interface [polypeptide binding]; other site
459424002985	active site
459424002986	Uncharacterized conserved protein [Function unknown]; Region: COG0062
459424002987	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
459424002988	putative substrate binding site [chemical binding]; other site
459424002989	putative ATP binding site [chemical binding]; other site
459424002990	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
459424002991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424002992	catalytic residue [active]
459424002993	alanine racemase; Reviewed; Region: alr; PRK00053
459424002994	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
459424002995	active site
459424002996	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
459424002997	dimer interface [polypeptide binding]; other site
459424002998	substrate binding site [chemical binding]; other site
459424002999	catalytic residues [active]
459424003000	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424003001	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
459424003002	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
459424003003	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
459424003004	Glycoprotease family; Region: Peptidase_M22; pfam00814
459424003005	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
459424003006	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424003007	Coenzyme A binding pocket [chemical binding]; other site
459424003008	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
459424003009	UGMP family protein; Validated; Region: PRK09604
459424003010	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
459424003011	oligomerisation interface [polypeptide binding]; other site
459424003012	mobile loop; other site
459424003013	roof hairpin; other site
459424003014	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
459424003015	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
459424003016	ring oligomerisation interface [polypeptide binding]; other site
459424003017	ATP/Mg binding site [chemical binding]; other site
459424003018	stacking interactions; other site
459424003019	hinge regions; other site
459424003020	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
459424003021	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003022	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003023	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003024	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003025	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003026	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003027	Transcription factor WhiB; Region: Whib; pfam02467
459424003028	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
459424003029	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424003030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
459424003031	DNA binding residues [nucleotide binding]
459424003032	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
459424003033	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
459424003034	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
459424003035	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
459424003036	active site
459424003037	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
459424003038	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
459424003039	phosphate binding site [ion binding]; other site
459424003040	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
459424003041	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424003042	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
459424003043	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
459424003044	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
459424003045	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003046	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003047	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
459424003048	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
459424003049	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
459424003050	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
459424003051	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
459424003052	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424003053	motif II; other site
459424003054	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424003055	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003056	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003057	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
459424003058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424003059	putative substrate translocation pore; other site
459424003060	Predicted transcriptional regulators [Transcription]; Region: COG1733
459424003061	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
459424003062	GMP synthase; Reviewed; Region: guaA; PRK00074
459424003063	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
459424003064	AMP/PPi binding site [chemical binding]; other site
459424003065	candidate oxyanion hole; other site
459424003066	catalytic triad [active]
459424003067	potential glutamine specificity residues [chemical binding]; other site
459424003068	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
459424003069	ATP Binding subdomain [chemical binding]; other site
459424003070	Ligand Binding sites [chemical binding]; other site
459424003071	Dimerization subdomain; other site
459424003072	DNA Polymerase Y-family; Region: PolY_like; cd03468
459424003073	active site
459424003074	DNA binding site [nucleotide binding]
459424003075	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
459424003076	active site
459424003077	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424003078	catalytic core [active]
459424003079	enoyl-CoA hydratase; Region: PLN02864
459424003080	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424003081	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
459424003082	dimer interaction site [polypeptide binding]; other site
459424003083	substrate-binding tunnel; other site
459424003084	active site
459424003085	catalytic site [active]
459424003086	substrate binding site [chemical binding]; other site
459424003087	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
459424003088	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
459424003089	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424003090	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424003091	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
459424003092	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
459424003093	active site
459424003094	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
459424003095	generic binding surface II; other site
459424003096	generic binding surface I; other site
459424003097	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
459424003098	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
459424003099	FMN binding site [chemical binding]; other site
459424003100	dimer interface [polypeptide binding]; other site
459424003101	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
459424003102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424003103	S-adenosylmethionine binding site [chemical binding]; other site
459424003104	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
459424003105	Protein of unknown function (DUF742); Region: DUF742; pfam05331
459424003106	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
459424003107	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
459424003108	G1 box; other site
459424003109	GTP/Mg2+ binding site [chemical binding]; other site
459424003110	G2 box; other site
459424003111	Switch I region; other site
459424003112	G3 box; other site
459424003113	Switch II region; other site
459424003114	G4 box; other site
459424003115	G5 box; other site
459424003116	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
459424003117	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
459424003118	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424003119	AMP-binding enzyme; Region: AMP-binding; pfam00501
459424003120	acyl-activating enzyme (AAE) consensus motif; other site
459424003121	active site
459424003122	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003123	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003124	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003125	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
459424003126	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
459424003127	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
459424003128	active site
459424003129	FMN binding site [chemical binding]; other site
459424003130	substrate binding site [chemical binding]; other site
459424003131	putative catalytic residue [active]
459424003132	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
459424003133	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
459424003134	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
459424003135	homodimer interface [polypeptide binding]; other site
459424003136	NADP binding site [chemical binding]; other site
459424003137	substrate binding site [chemical binding]; other site
459424003138	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
459424003139	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424003140	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
459424003141	FAD binding domain; Region: FAD_binding_4; pfam01565
459424003142	Berberine and berberine like; Region: BBE; pfam08031
459424003143	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424003144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424003145	S-adenosylmethionine binding site [chemical binding]; other site
459424003146	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
459424003147	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
459424003148	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
459424003149	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
459424003150	homodimer interface [polypeptide binding]; other site
459424003151	substrate-cofactor binding pocket; other site
459424003152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424003153	catalytic residue [active]
459424003154	isocitrate dehydrogenase; Validated; Region: PRK08299
459424003155	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424003156	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
459424003157	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
459424003158	active site
459424003159	HIGH motif; other site
459424003160	dimer interface [polypeptide binding]; other site
459424003161	KMSKS motif; other site
459424003162	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
459424003163	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
459424003164	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
459424003165	active site
459424003166	dimer interface [polypeptide binding]; other site
459424003167	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
459424003168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424003169	putative substrate translocation pore; other site
459424003170	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
459424003171	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
459424003172	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
459424003173	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
459424003174	DNA binding residues [nucleotide binding]
459424003175	PE family; Region: PE; pfam00934
459424003176	PE family; Region: PE; pfam00934
459424003177	Uncharacterized conserved protein [Function unknown]; Region: COG2128
459424003178	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
459424003179	peptide synthase; Provisional; Region: PRK12316
459424003180	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
459424003181	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
459424003182	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
459424003183	L-aspartate oxidase; Provisional; Region: PRK06175
459424003184	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
459424003185	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
459424003186	putative Iron-sulfur protein interface [polypeptide binding]; other site
459424003187	putative proximal heme binding site [chemical binding]; other site
459424003188	putative SdhC-like subunit interface [polypeptide binding]; other site
459424003189	putative distal heme binding site [chemical binding]; other site
459424003190	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
459424003191	putative Iron-sulfur protein interface [polypeptide binding]; other site
459424003192	putative proximal heme binding site [chemical binding]; other site
459424003193	putative SdhD-like interface [polypeptide binding]; other site
459424003194	putative distal heme binding site [chemical binding]; other site
459424003195	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
459424003196	active site
459424003197	catalytic motif [active]
459424003198	Zn binding site [ion binding]; other site
459424003199	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
459424003200	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
459424003201	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
459424003202	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
459424003203	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
459424003204	adenosine deaminase; Provisional; Region: PRK09358
459424003205	active site
459424003206	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
459424003207	allantoicase; Provisional; Region: PRK13257
459424003208	Allantoicase repeat; Region: Allantoicase; pfam03561
459424003209	Allantoicase repeat; Region: Allantoicase; pfam03561
459424003210	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
459424003211	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
459424003212	active site
459424003213	catalytic site [active]
459424003214	tetramer interface [polypeptide binding]; other site
459424003215	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
459424003216	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
459424003217	Na binding site [ion binding]; other site
459424003218	putative substrate binding site [chemical binding]; other site
459424003219	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424003220	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424003221	active site
459424003222	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
459424003223	Phosphoesterase family; Region: Phosphoesterase; pfam04185
459424003224	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
459424003225	active site
459424003226	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
459424003227	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
459424003228	active site
459424003229	substrate binding site [chemical binding]; other site
459424003230	metal binding site [ion binding]; metal-binding site
459424003231	purine nucleoside phosphorylase; Provisional; Region: PRK08202
459424003232	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
459424003233	amidohydrolase; Region: amidohydrolases; TIGR01891
459424003234	metal binding site [ion binding]; metal-binding site
459424003235	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
459424003236	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
459424003237	metal binding site [ion binding]; metal-binding site
459424003238	putative dimer interface [polypeptide binding]; other site
459424003239	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
459424003240	dimerization interface [polypeptide binding]; other site
459424003241	putative active site pocket [active]
459424003242	putative catalytic residue [active]
459424003243	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
459424003244	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424003245	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
459424003246	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
459424003247	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
459424003248	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
459424003249	active site
459424003250	FMN binding site [chemical binding]; other site
459424003251	substrate binding site [chemical binding]; other site
459424003252	3Fe-4S cluster binding site [ion binding]; other site
459424003253	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424003254	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
459424003255	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424003256	motif II; other site
459424003257	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
459424003258	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
459424003259	PhoU domain; Region: PhoU; pfam01895
459424003260	PhoU domain; Region: PhoU; pfam01895
459424003261	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
459424003262	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
459424003263	active site
459424003264	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
459424003265	Sulfatase; Region: Sulfatase; pfam00884
459424003266	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424003267	PBP superfamily domain; Region: PBP_like_2; cl17296
459424003268	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
459424003269	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
459424003270	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
459424003271	putative DNA binding site [nucleotide binding]; other site
459424003272	catalytic residue [active]
459424003273	putative H2TH interface [polypeptide binding]; other site
459424003274	putative catalytic residues [active]
459424003275	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
459424003276	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003277	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003278	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
459424003279	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
459424003280	tetrameric interface [polypeptide binding]; other site
459424003281	NAD binding site [chemical binding]; other site
459424003282	catalytic residues [active]
459424003283	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
459424003284	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
459424003285	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
459424003286	AsnC family; Region: AsnC_trans_reg; pfam01037
459424003287	L-lysine aminotransferase; Provisional; Region: PRK08297
459424003288	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424003289	inhibitor-cofactor binding pocket; inhibition site
459424003290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424003291	catalytic residue [active]
459424003292	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
459424003293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
459424003294	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
459424003295	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424003296	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
459424003297	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
459424003298	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003299	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003300	WHG domain; Region: WHG; pfam13305
459424003301	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
459424003302	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
459424003303	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
459424003304	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
459424003305	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
459424003306	carboxyltransferase (CT) interaction site; other site
459424003307	biotinylation site [posttranslational modification]; other site
459424003308	Fe-S metabolism associated domain; Region: SufE; cl00951
459424003309	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
459424003310	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
459424003311	active site residue [active]
459424003312	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
459424003313	active site residue [active]
459424003314	Maf-like protein; Region: Maf; pfam02545
459424003315	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
459424003316	active site
459424003317	dimer interface [polypeptide binding]; other site
459424003318	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
459424003319	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
459424003320	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
459424003321	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
459424003322	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
459424003323	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
459424003324	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
459424003325	Bacterial PH domain; Region: DUF304; pfam03703
459424003326	Predicted membrane protein [Function unknown]; Region: COG2246
459424003327	GtrA-like protein; Region: GtrA; pfam04138
459424003328	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
459424003329	ATP-grasp domain; Region: ATP-grasp; pfam02222
459424003330	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
459424003331	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424003332	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
459424003333	FAD binding site [chemical binding]; other site
459424003334	homotetramer interface [polypeptide binding]; other site
459424003335	substrate binding pocket [chemical binding]; other site
459424003336	catalytic base [active]
459424003337	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
459424003338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424003339	active site
459424003340	phosphorylation site [posttranslational modification]
459424003341	intermolecular recognition site; other site
459424003342	dimerization interface [polypeptide binding]; other site
459424003343	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
459424003344	Response regulator receiver domain; Region: Response_reg; pfam00072
459424003345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424003346	active site
459424003347	phosphorylation site [posttranslational modification]
459424003348	intermolecular recognition site; other site
459424003349	dimerization interface [polypeptide binding]; other site
459424003350	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
459424003351	Sulfate transporter family; Region: Sulfate_transp; pfam00916
459424003352	active site clefts [active]
459424003353	Carbonic anhydrase; Region: Pro_CA; smart00947
459424003354	zinc binding site [ion binding]; other site
459424003355	dimer interface [polypeptide binding]; other site
459424003356	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424003357	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424003358	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003360	Predicted acyl esterases [General function prediction only]; Region: COG2936
459424003361	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
459424003362	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
459424003363	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424003364	Soluble P-type ATPase [General function prediction only]; Region: COG4087
459424003365	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
459424003366	TIGR03089 family protein; Region: TIGR03089
459424003367	Transcriptional regulator [Transcription]; Region: LytR; COG1316
459424003368	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
459424003369	dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214
459424003370	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
459424003371	NADP binding site [chemical binding]; other site
459424003372	active site
459424003373	putative substrate binding site [chemical binding]; other site
459424003374	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
459424003375	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
459424003376	Probable Catalytic site; other site
459424003377	metal-binding site
459424003378	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
459424003379	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
459424003380	active site
459424003381	Substrate binding site; other site
459424003382	Mg++ binding site; other site
459424003383	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
459424003384	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
459424003385	nudix motif; other site
459424003386	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
459424003387	Methyltransferase domain; Region: Methyltransf_26; pfam13659
459424003388	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
459424003389	F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916
459424003390	F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553
459424003391	FMN binding site [chemical binding]; other site
459424003392	dimer interface [polypeptide binding]; other site
459424003393	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
459424003394	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
459424003395	dimer interface [polypeptide binding]; other site
459424003396	substrate binding site [chemical binding]; other site
459424003397	phosphate binding site [ion binding]; other site
459424003398	Transcription factor WhiB; Region: Whib; pfam02467
459424003399	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
459424003400	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
459424003401	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
459424003402	active site
459424003403	substrate binding site [chemical binding]; other site
459424003404	metal binding site [ion binding]; metal-binding site
459424003405	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
459424003406	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
459424003407	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
459424003408	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
459424003409	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424003410	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
459424003411	amino acid transporter; Region: 2A0306; TIGR00909
459424003412	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
459424003413	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
459424003414	Fatty acid desaturase; Region: FA_desaturase; pfam00487
459424003415	Di-iron ligands [ion binding]; other site
459424003416	Rubredoxin [Energy production and conversion]; Region: COG1773
459424003417	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
459424003418	iron binding site [ion binding]; other site
459424003419	Rubredoxin [Energy production and conversion]; Region: COG1773
459424003420	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
459424003421	iron binding site [ion binding]; other site
459424003422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003423	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
459424003424	Adenosylhomocysteinase; Provisional; Region: PTZ00075
459424003425	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
459424003426	homotetramer interface [polypeptide binding]; other site
459424003427	ligand binding site [chemical binding]; other site
459424003428	catalytic site [active]
459424003429	NAD binding site [chemical binding]; other site
459424003430	PE family; Region: PE; pfam00934
459424003431	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003432	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003433	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003434	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
459424003435	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
459424003436	TMP-binding site; other site
459424003437	ATP-binding site [chemical binding]; other site
459424003438	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424003439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424003440	active site
459424003441	phosphorylation site [posttranslational modification]
459424003442	intermolecular recognition site; other site
459424003443	dimerization interface [polypeptide binding]; other site
459424003444	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424003445	DNA binding site [nucleotide binding]
459424003446	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
459424003447	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424003448	dimerization interface [polypeptide binding]; other site
459424003449	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
459424003450	dimer interface [polypeptide binding]; other site
459424003451	phosphorylation site [posttranslational modification]
459424003452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424003453	ATP binding site [chemical binding]; other site
459424003454	Mg2+ binding site [ion binding]; other site
459424003455	G-X-G motif; other site
459424003456	lipoprotein LpqB; Provisional; Region: PRK13616
459424003457	Sporulation and spore germination; Region: Germane; pfam10646
459424003458	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
459424003459	30S subunit binding site; other site
459424003460	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
459424003461	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
459424003462	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003463	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003464	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003465	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003466	Phospholipid methyltransferase; Region: PEMT; cl17370
459424003467	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
459424003468	TrkA-C domain; Region: TrkA_C; pfam02080
459424003469	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
459424003470	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
459424003471	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424003472	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424003473	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
459424003474	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
459424003475	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
459424003476	FAD binding pocket [chemical binding]; other site
459424003477	FAD binding motif [chemical binding]; other site
459424003478	phosphate binding motif [ion binding]; other site
459424003479	beta-alpha-beta structure motif; other site
459424003480	NAD binding pocket [chemical binding]; other site
459424003481	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424003482	catalytic loop [active]
459424003483	iron binding site [ion binding]; other site
459424003484	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
459424003485	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
459424003486	putative di-iron ligands [ion binding]; other site
459424003487	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
459424003488	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
459424003489	putative di-iron ligands [ion binding]; other site
459424003490	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
459424003491	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424003492	dimer interface [polypeptide binding]; other site
459424003493	active site
459424003494	Predicted transcriptional regulators [Transcription]; Region: COG1733
459424003495	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
459424003496	Predicted GTPases [General function prediction only]; Region: COG1162
459424003497	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
459424003498	GTPase/Zn-binding domain interface [polypeptide binding]; other site
459424003499	GTP/Mg2+ binding site [chemical binding]; other site
459424003500	G4 box; other site
459424003501	G5 box; other site
459424003502	G1 box; other site
459424003503	Switch I region; other site
459424003504	G2 box; other site
459424003505	G3 box; other site
459424003506	Switch II region; other site
459424003507	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
459424003508	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
459424003509	hinge; other site
459424003510	active site
459424003511	Uncharacterized conserved protein [Function unknown]; Region: COG2135
459424003512	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
459424003513	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
459424003514	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
459424003515	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424003516	AAA ATPase domain; Region: AAA_16; pfam13191
459424003517	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
459424003518	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
459424003519	DNA binding residues [nucleotide binding]
459424003520	dimerization interface [polypeptide binding]; other site
459424003521	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003522	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003523	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003524	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
459424003525	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
459424003526	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
459424003527	putative deacylase active site [active]
459424003528	short chain dehydrogenase; Provisional; Region: PRK08278
459424003529	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
459424003530	NAD(P) binding site [chemical binding]; other site
459424003531	homodimer interface [polypeptide binding]; other site
459424003532	active site
459424003533	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
459424003534	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424003535	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424003536	DNA binding residues [nucleotide binding]
459424003537	anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin
459424003538	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
459424003539	carboxyltransferase (CT) interaction site; other site
459424003540	biotinylation site [posttranslational modification]; other site
459424003541	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
459424003542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
459424003543	Histidine kinase; Region: HisKA_2; pfam07568
459424003544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424003545	ATP binding site [chemical binding]; other site
459424003546	Mg2+ binding site [ion binding]; other site
459424003547	G-X-G motif; other site
459424003548	Transcription factor WhiB; Region: Whib; pfam02467
459424003549	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
459424003550	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
459424003551	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
459424003552	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
459424003553	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
459424003554	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424003555	catalytic core [active]
459424003556	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
459424003557	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
459424003558	P-loop; other site
459424003559	Magnesium ion binding site [ion binding]; other site
459424003560	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
459424003561	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
459424003562	Magnesium ion binding site [ion binding]; other site
459424003563	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
459424003564	DEAD-like helicases superfamily; Region: DEXDc; smart00487
459424003565	ATP binding site [chemical binding]; other site
459424003566	Mg++ binding site [ion binding]; other site
459424003567	motif III; other site
459424003568	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
459424003569	nucleotide binding region [chemical binding]; other site
459424003570	ATP-binding site [chemical binding]; other site
459424003571	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
459424003572	dinuclear metal binding motif [ion binding]; other site
459424003573	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
459424003574	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003576	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
459424003577	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
459424003578	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
459424003579	ATP binding site [chemical binding]; other site
459424003580	substrate interface [chemical binding]; other site
459424003581	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
459424003582	active site residue [active]
459424003583	TIGR02569 family protein; Region: TIGR02569_actnb
459424003584	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
459424003585	active site
459424003586	DNA binding site [nucleotide binding]
459424003587	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424003588	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424003589	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
459424003590	catalytic site [active]
459424003591	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
459424003592	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
459424003593	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
459424003594	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
459424003595	Part of AAA domain; Region: AAA_19; pfam13245
459424003596	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
459424003597	Ion channel; Region: Ion_trans_2; pfam07885
459424003598	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
459424003599	TrkA-N domain; Region: TrkA_N; pfam02254
459424003600	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
459424003601	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
459424003602	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
459424003603	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
459424003604	putative NADH binding site [chemical binding]; other site
459424003605	putative active site [active]
459424003606	nudix motif; other site
459424003607	putative metal binding site [ion binding]; other site
459424003608	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424003609	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
459424003610	catalytic residues [active]
459424003611	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
459424003612	Part of AAA domain; Region: AAA_19; pfam13245
459424003613	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
459424003614	Family description; Region: UvrD_C_2; pfam13538
459424003615	HRDC domain; Region: HRDC; pfam00570
459424003616	Transcription factor WhiB; Region: Whib; pfam02467
459424003617	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
459424003618	ABC1 family; Region: ABC1; pfam03109
459424003619	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
459424003620	active site
459424003621	ATP binding site [chemical binding]; other site
459424003622	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
459424003623	Uncharacterized conserved protein [Function unknown]; Region: COG5282
459424003624	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
459424003625	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
459424003626	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
459424003627	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
459424003628	hypothetical protein; Validated; Region: PRK00068
459424003629	Uncharacterized conserved protein [Function unknown]; Region: COG1615
459424003630	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
459424003631	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424003632	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
459424003633	SnoaL-like domain; Region: SnoaL_4; pfam13577
459424003634	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424003635	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424003636	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
459424003637	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424003638	non-specific DNA binding site [nucleotide binding]; other site
459424003639	salt bridge; other site
459424003640	sequence-specific DNA binding site [nucleotide binding]; other site
459424003641	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
459424003642	Domain of unknown function (DUF955); Region: DUF955; pfam06114
459424003643	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
459424003644	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
459424003645	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
459424003646	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
459424003647	tetramer interface [polypeptide binding]; other site
459424003648	active site
459424003649	Mg2+/Mn2+ binding site [ion binding]; other site
459424003650	citrate synthase; Provisional; Region: PRK14033
459424003651	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
459424003652	oxalacetate binding site [chemical binding]; other site
459424003653	citrylCoA binding site [chemical binding]; other site
459424003654	coenzyme A binding site [chemical binding]; other site
459424003655	catalytic triad [active]
459424003656	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
459424003657	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
459424003658	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424003659	probable polyamine oxidase; Region: PLN02268
459424003660	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424003661	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424003662	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424003663	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
459424003664	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424003665	hydroxyglutarate oxidase; Provisional; Region: PRK11728
459424003666	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
459424003667	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424003668	PE family; Region: PE; pfam00934
459424003669	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
459424003670	putative active site [active]
459424003671	putative substrate binding site [chemical binding]; other site
459424003672	ATP binding site [chemical binding]; other site
459424003673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003675	classical (c) SDRs; Region: SDR_c; cd05233
459424003676	NAD(P) binding site [chemical binding]; other site
459424003677	active site
459424003678	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
459424003679	MoxR-like ATPases [General function prediction only]; Region: COG0714
459424003680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424003681	Walker A motif; other site
459424003682	ATP binding site [chemical binding]; other site
459424003683	Walker B motif; other site
459424003684	arginine finger; other site
459424003685	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
459424003686	Protein of unknown function DUF58; Region: DUF58; pfam01882
459424003687	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003688	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003689	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003690	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003691	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003692	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003693	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424003694	PPE family; Region: PPE; pfam00823
459424003695	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
459424003696	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
459424003697	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
459424003698	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
459424003699	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
459424003700	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
459424003701	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
459424003702	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
459424003703	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
459424003704	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
459424003705	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
459424003706	4Fe-4S binding domain; Region: Fer4; pfam00037
459424003707	4Fe-4S binding domain; Region: Fer4; pfam00037
459424003708	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
459424003709	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
459424003710	NADH dehydrogenase subunit G; Validated; Region: PRK07860
459424003711	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424003712	catalytic loop [active]
459424003713	iron binding site [ion binding]; other site
459424003714	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
459424003715	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
459424003716	molybdopterin cofactor binding site; other site
459424003717	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
459424003718	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
459424003719	SLBB domain; Region: SLBB; pfam10531
459424003720	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
459424003721	NADH dehydrogenase subunit E; Validated; Region: PRK07539
459424003722	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
459424003723	putative dimer interface [polypeptide binding]; other site
459424003724	[2Fe-2S] cluster binding site [ion binding]; other site
459424003725	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
459424003726	NADH dehydrogenase subunit D; Validated; Region: PRK06075
459424003727	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
459424003728	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
459424003729	NADH dehydrogenase subunit B; Validated; Region: PRK06411
459424003730	NADH dehydrogenase subunit A; Validated; Region: PRK07928
459424003731	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003732	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003733	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
459424003735	active site
459424003736	phosphorylation site [posttranslational modification]
459424003737	intermolecular recognition site; other site
459424003738	YceI-like domain; Region: YceI; pfam04264
459424003739	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003740	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003741	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003742	Phosphotransferase enzyme family; Region: APH; pfam01636
459424003743	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
459424003744	putative active site [active]
459424003745	putative substrate binding site [chemical binding]; other site
459424003746	ATP binding site [chemical binding]; other site
459424003747	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424003748	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424003749	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
459424003750	active site
459424003751	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003752	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003753	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
459424003754	active site
459424003755	catalytic residues [active]
459424003756	metal binding site [ion binding]; metal-binding site
459424003757	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424003758	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424003759	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
459424003760	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424003761	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
459424003762	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
459424003763	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003764	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003765	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003766	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
459424003767	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
459424003768	NAD(P) binding site [chemical binding]; other site
459424003769	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
459424003770	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
459424003771	NADP binding site [chemical binding]; other site
459424003772	dimer interface [polypeptide binding]; other site
459424003773	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424003774	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
459424003775	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
459424003776	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
459424003777	active site
459424003778	Fe binding site [ion binding]; other site
459424003779	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
459424003780	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
459424003781	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424003782	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424003783	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003784	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003785	acetaldehyde dehydrogenase; Validated; Region: PRK08300
459424003786	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
459424003787	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
459424003788	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
459424003789	active site
459424003790	metal binding site [ion binding]; metal-binding site
459424003791	DmpG-like communication domain; Region: DmpG_comm; pfam07836
459424003792	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
459424003793	acetolactate synthase; Reviewed; Region: PRK08617
459424003794	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
459424003795	PYR/PP interface [polypeptide binding]; other site
459424003796	dimer interface [polypeptide binding]; other site
459424003797	TPP binding site [chemical binding]; other site
459424003798	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
459424003799	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
459424003800	TPP-binding site [chemical binding]; other site
459424003801	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424003802	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424003803	active site
459424003804	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424003805	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424003806	active site
459424003807	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
459424003808	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
459424003809	active site
459424003810	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424003811	PPE family; Region: PPE; pfam00823
459424003812	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424003813	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003814	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003815	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003816	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003817	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003818	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003819	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424003820	Ligand Binding Site [chemical binding]; other site
459424003821	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
459424003822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424003823	active site
459424003824	phosphorylation site [posttranslational modification]
459424003825	intermolecular recognition site; other site
459424003826	dimerization interface [polypeptide binding]; other site
459424003827	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
459424003828	DNA binding residues [nucleotide binding]
459424003829	dimerization interface [polypeptide binding]; other site
459424003830	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
459424003831	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
459424003832	GAF domain; Region: GAF_3; pfam13492
459424003833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
459424003834	Histidine kinase; Region: HisKA_3; pfam07730
459424003835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424003836	ATP binding site [chemical binding]; other site
459424003837	Mg2+ binding site [ion binding]; other site
459424003838	G-X-G motif; other site
459424003839	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424003840	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424003841	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424003842	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
459424003843	heme-binding site [chemical binding]; other site
459424003844	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
459424003845	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424003846	dimer interface [polypeptide binding]; other site
459424003847	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424003848	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
459424003849	FAD binding domain; Region: FAD_binding_4; pfam01565
459424003850	ferredoxin-NADP+ reductase; Region: PLN02852
459424003851	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424003852	peptide chain release factor 2; Validated; Region: prfB; PRK00578
459424003853	This domain is found in peptide chain release factors; Region: PCRF; smart00937
459424003854	RF-1 domain; Region: RF-1; pfam00472
459424003855	Mechanosensitive ion channel; Region: MS_channel; pfam00924
459424003856	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
459424003857	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
459424003858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424003859	Walker A/P-loop; other site
459424003860	ATP binding site [chemical binding]; other site
459424003861	Q-loop/lid; other site
459424003862	ABC transporter signature motif; other site
459424003863	Walker B; other site
459424003864	D-loop; other site
459424003865	H-loop/switch region; other site
459424003866	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
459424003867	FtsX-like permease family; Region: FtsX; pfam02687
459424003868	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
459424003869	SmpB-tmRNA interface; other site
459424003870	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003871	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003872	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003873	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003874	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003875	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
459424003876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424003877	ATP binding site [chemical binding]; other site
459424003878	Walker B motif; other site
459424003879	arginine finger; other site
459424003880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
459424003881	TPR motif; other site
459424003882	binding surface
459424003883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
459424003884	TPR motif; other site
459424003885	TPR repeat; Region: TPR_11; pfam13414
459424003886	binding surface
459424003887	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424003888	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
459424003889	MspA; Region: MspA; pfam09203
459424003890	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424003891	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
459424003892	active site
459424003893	Predicted transcriptional regulators [Transcription]; Region: COG1695
459424003894	Transcriptional regulator PadR-like family; Region: PadR; cl17335
459424003895	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
459424003896	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424003897	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003898	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003899	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003900	PPE family; Region: PPE; pfam00823
459424003901	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424003902	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
459424003903	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424003904	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003905	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003906	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003907	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
459424003908	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424003909	PPE family; Region: PPE; pfam00823
459424003910	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
459424003911	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
459424003912	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
459424003913	Predicted transcriptional regulators [Transcription]; Region: COG1733
459424003914	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424003915	dimerization interface [polypeptide binding]; other site
459424003916	putative DNA binding site [nucleotide binding]; other site
459424003917	putative Zn2+ binding site [ion binding]; other site
459424003918	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424003919	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424003920	active site
459424003921	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
459424003922	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424003923	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
459424003924	Prostaglandin dehydrogenases; Region: PGDH; cd05288
459424003925	NAD(P) binding site [chemical binding]; other site
459424003926	substrate binding site [chemical binding]; other site
459424003927	dimer interface [polypeptide binding]; other site
459424003928	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
459424003929	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
459424003930	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
459424003931	homodimer interface [polypeptide binding]; other site
459424003932	metal binding site [ion binding]; metal-binding site
459424003933	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
459424003934	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
459424003935	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
459424003936	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
459424003937	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424003938	Cytochrome P450; Region: p450; cl12078
459424003939	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424003940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424003941	S-adenosylmethionine binding site [chemical binding]; other site
459424003942	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003943	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003944	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003945	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
459424003946	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
459424003947	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424003948	FeS/SAM binding site; other site
459424003949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
459424003950	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424003951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424003952	NAD(P) binding site [chemical binding]; other site
459424003953	active site
459424003954	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424003955	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424003956	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424003957	SPFH domain / Band 7 family; Region: Band_7; pfam01145
459424003958	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
459424003959	hypothetical protein; Validated; Region: PRK00029
459424003960	Uncharacterized conserved protein [Function unknown]; Region: COG0397
459424003961	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
459424003962	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424003963	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424003964	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
459424003965	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
459424003966	putative hydrophobic ligand binding site [chemical binding]; other site
459424003967	protein interface [polypeptide binding]; other site
459424003968	gate; other site
459424003969	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
459424003970	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
459424003971	active site
459424003972	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
459424003973	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424003974	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
459424003975	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424003976	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424003977	active site
459424003978	Protein of unknown function, DUF488; Region: DUF488; cl01246
459424003979	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424003980	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424003981	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
459424003982	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
459424003983	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
459424003984	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
459424003985	Uncharacterized ACR, COG1993; Region: DUF190; pfam02641
459424003986	camphor resistance protein CrcB; Provisional; Region: PRK14228
459424003987	camphor resistance protein CrcB; Provisional; Region: PRK14216
459424003988	phosphoglucomutase; Validated; Region: PRK07564
459424003989	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
459424003990	active site
459424003991	substrate binding site [chemical binding]; other site
459424003992	metal binding site [ion binding]; metal-binding site
459424003993	Uncharacterized conserved protein [Function unknown]; Region: COG3391
459424003994	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003995	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424003996	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424003997	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424003998	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424003999	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424004000	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424004001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424004002	S-adenosylmethionine binding site [chemical binding]; other site
459424004003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424004004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424004005	Transposase; Region: HTH_Tnp_1; cl17663
459424004006	HTH-like domain; Region: HTH_21; pfam13276
459424004007	Integrase core domain; Region: rve; pfam00665
459424004008	Integrase core domain; Region: rve_3; pfam13683
459424004009	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424004010	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004011	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004012	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004013	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
459424004014	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
459424004015	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
459424004016	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424004017	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424004018	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
459424004019	putative acyl-acceptor binding pocket; other site
459424004020	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424004021	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424004022	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
459424004023	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
459424004024	acyl-activating enzyme (AAE) consensus motif; other site
459424004025	putative AMP binding site [chemical binding]; other site
459424004026	putative active site [active]
459424004027	putative CoA binding site [chemical binding]; other site
459424004028	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
459424004029	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
459424004030	NAD(P) binding site [chemical binding]; other site
459424004031	catalytic residues [active]
459424004032	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
459424004033	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
459424004034	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
459424004035	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424004036	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
459424004037	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
459424004038	short chain dehydrogenase; Provisional; Region: PRK06180
459424004039	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
459424004040	NADP binding site [chemical binding]; other site
459424004041	active site
459424004042	steroid binding site; other site
459424004043	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004044	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004045	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004046	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
459424004047	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
459424004048	nucleotide binding site [chemical binding]; other site
459424004049	putative NEF/HSP70 interaction site [polypeptide binding]; other site
459424004050	SBD interface [polypeptide binding]; other site
459424004051	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004052	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004053	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004054	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004055	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004056	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004057	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424004058	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424004059	ligand binding site [chemical binding]; other site
459424004060	flexible hinge region; other site
459424004061	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
459424004062	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
459424004063	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
459424004064	active site
459424004065	DNA binding site [nucleotide binding]
459424004066	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
459424004067	DNA binding site [nucleotide binding]
459424004068	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424004069	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424004070	NAD(P) binding site [chemical binding]; other site
459424004071	active site
459424004072	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424004073	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424004074	Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441
459424004075	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424004076	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424004077	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424004078	active site
459424004079	Predicted transcriptional regulators [Transcription]; Region: COG1733
459424004080	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424004081	dimerization interface [polypeptide binding]; other site
459424004082	putative DNA binding site [nucleotide binding]; other site
459424004083	putative Zn2+ binding site [ion binding]; other site
459424004084	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424004085	S-adenosylmethionine binding site [chemical binding]; other site
459424004086	DUF35 OB-fold domain; Region: DUF35; pfam01796
459424004087	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424004088	active site
459424004089	Transcriptional regulators [Transcription]; Region: FadR; COG2186
459424004090	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424004091	DNA-binding site [nucleotide binding]; DNA binding site
459424004092	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
459424004093	Transcriptional regulators [Transcription]; Region: FadR; COG2186
459424004094	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
459424004095	DNA-binding site [nucleotide binding]; DNA binding site
459424004096	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
459424004097	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
459424004098	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
459424004099	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
459424004100	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
459424004101	Cytochrome P450; Region: p450; cl12078
459424004102	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424004103	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424004104	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424004105	short chain dehydrogenase; Provisional; Region: PRK07832
459424004106	classical (c) SDRs; Region: SDR_c; cd05233
459424004107	NAD(P) binding site [chemical binding]; other site
459424004108	active site
459424004109	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424004110	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424004111	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
459424004112	Predicted flavoprotein [General function prediction only]; Region: COG0431
459424004113	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
459424004114	catalytic residues [active]
459424004115	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
459424004116	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
459424004117	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
459424004118	Class I ribonucleotide reductase; Region: RNR_I; cd01679
459424004119	active site
459424004120	dimer interface [polypeptide binding]; other site
459424004121	catalytic residues [active]
459424004122	effector binding site; other site
459424004123	R2 peptide binding site; other site
459424004124	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424004125	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424004126	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424004127	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424004128	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424004129	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424004130	Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
459424004131	putative hydrophobic ligand binding site [chemical binding]; other site
459424004132	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
459424004133	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
459424004134	dimer interface [polypeptide binding]; other site
459424004135	putative radical transfer pathway; other site
459424004136	diiron center [ion binding]; other site
459424004137	tyrosyl radical; other site
459424004138	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
459424004139	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
459424004140	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
459424004141	putative NAD(P) binding site [chemical binding]; other site
459424004142	putative substrate binding site [chemical binding]; other site
459424004143	catalytic Zn binding site [ion binding]; other site
459424004144	structural Zn binding site [ion binding]; other site
459424004145	dimer interface [polypeptide binding]; other site
459424004146	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
459424004147	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
459424004148	siderophore binding site; other site
459424004149	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
459424004150	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
459424004151	D-pathway; other site
459424004152	Putative ubiquinol binding site [chemical binding]; other site
459424004153	Low-spin heme (heme b) binding site [chemical binding]; other site
459424004154	Putative water exit pathway; other site
459424004155	Binuclear center (heme o3/CuB) [ion binding]; other site
459424004156	K-pathway; other site
459424004157	Putative proton exit pathway; other site
459424004158	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
459424004159	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
459424004160	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
459424004161	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424004162	motif II; other site
459424004163	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424004164	dimerization interface [polypeptide binding]; other site
459424004165	putative DNA binding site [nucleotide binding]; other site
459424004166	putative Zn2+ binding site [ion binding]; other site
459424004167	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
459424004168	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
459424004169	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
459424004170	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
459424004171	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
459424004172	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
459424004173	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
459424004174	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
459424004175	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424004176	Walker A/P-loop; other site
459424004177	ATP binding site [chemical binding]; other site
459424004178	Q-loop/lid; other site
459424004179	ABC transporter signature motif; other site
459424004180	Walker B; other site
459424004181	D-loop; other site
459424004182	H-loop/switch region; other site
459424004183	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
459424004184	nudix motif; other site
459424004185	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424004186	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
459424004187	substrate binding site [chemical binding]; other site
459424004188	oxyanion hole (OAH) forming residues; other site
459424004189	trimer interface [polypeptide binding]; other site
459424004190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424004191	S-adenosylmethionine binding site [chemical binding]; other site
459424004192	Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263
459424004193	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
459424004194	FOG: WD40-like repeat [Function unknown]; Region: COG1520
459424004195	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
459424004196	Trp docking motif [polypeptide binding]; other site
459424004197	active site
459424004198	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
459424004199	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
459424004200	trimer interface [polypeptide binding]; other site
459424004201	active site
459424004202	substrate binding site [chemical binding]; other site
459424004203	CoA binding site [chemical binding]; other site
459424004204	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424004205	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
459424004206	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
459424004207	DNA photolyase; Region: DNA_photolyase; pfam00875
459424004208	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
459424004209	TspO/MBR family; Region: TspO_MBR; pfam03073
459424004210	MMPL family; Region: MMPL; pfam03176
459424004211	MMPL family; Region: MMPL; pfam03176
459424004212	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
459424004213	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424004214	Transcriptional regulators [Transcription]; Region: MarR; COG1846
459424004215	MarR family; Region: MarR; pfam01047
459424004216	SOUL heme-binding protein; Region: SOUL; pfam04832
459424004217	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
459424004218	putative hydrophobic ligand binding site [chemical binding]; other site
459424004219	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
459424004220	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
459424004221	putative NAD(P) binding site [chemical binding]; other site
459424004222	putative active site [active]
459424004223	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
459424004224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424004225	NAD(P) binding site [chemical binding]; other site
459424004226	active site
459424004227	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424004228	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
459424004229	Uncharacterized conserved protein [Function unknown]; Region: COG1543
459424004230	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
459424004231	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
459424004232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424004233	S-adenosylmethionine binding site [chemical binding]; other site
459424004234	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
459424004235	Ligand binding site [chemical binding]; other site
459424004236	Electron transfer flavoprotein domain; Region: ETF; pfam01012
459424004237	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
459424004238	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
459424004239	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
459424004240	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
459424004241	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424004242	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
459424004243	putative acyl-acceptor binding pocket; other site
459424004244	Domain of unknown function (DUF427); Region: DUF427; pfam04248
459424004245	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
459424004246	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
459424004247	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424004248	catalytic residue [active]
459424004249	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
459424004250	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
459424004251	Ligand Binding Site [chemical binding]; other site
459424004252	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424004253	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
459424004254	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
459424004255	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
459424004256	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424004257	FeS/SAM binding site; other site
459424004258	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
459424004259	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
459424004260	nucleotide binding pocket [chemical binding]; other site
459424004261	K-X-D-G motif; other site
459424004262	catalytic site [active]
459424004263	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
459424004264	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
459424004265	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
459424004266	Dimer interface [polypeptide binding]; other site
459424004267	BRCT sequence motif; other site
459424004268	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424004269	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424004270	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424004271	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
459424004272	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
459424004273	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
459424004274	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
459424004275	6-phosphofructokinase; Provisional; Region: PRK03202
459424004276	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
459424004277	dimerization interface [polypeptide binding]; other site
459424004278	allosteric effector site; other site
459424004279	active site
459424004280	ADP/pyrophosphate binding site [chemical binding]; other site
459424004281	fructose-1,6-bisphosphate binding site; other site
459424004282	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
459424004283	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
459424004284	GatB domain; Region: GatB_Yqey; smart00845
459424004285	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
459424004286	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
459424004287	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
459424004288	Predicted membrane protein [Function unknown]; Region: COG2259
459424004289	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
459424004290	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
459424004291	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
459424004292	PYR/PP interface [polypeptide binding]; other site
459424004293	dimer interface [polypeptide binding]; other site
459424004294	TPP binding site [chemical binding]; other site
459424004295	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
459424004296	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
459424004297	TPP-binding site [chemical binding]; other site
459424004298	dimer interface [polypeptide binding]; other site
459424004299	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
459424004300	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
459424004301	putative valine binding site [chemical binding]; other site
459424004302	dimer interface [polypeptide binding]; other site
459424004303	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
459424004304	ketol-acid reductoisomerase; Provisional; Region: PRK05479
459424004305	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
459424004306	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
459424004307	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
459424004308	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
459424004309	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
459424004310	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
459424004311	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
459424004312	ligand binding site [chemical binding]; other site
459424004313	NAD binding site [chemical binding]; other site
459424004314	dimerization interface [polypeptide binding]; other site
459424004315	catalytic site [active]
459424004316	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
459424004317	putative L-serine binding site [chemical binding]; other site
459424004318	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
459424004319	tartrate dehydrogenase; Region: TTC; TIGR02089
459424004320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424004321	Major Facilitator Superfamily; Region: MFS_1; pfam07690
459424004322	putative substrate translocation pore; other site
459424004323	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004324	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
459424004325	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
459424004326	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
459424004327	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
459424004328	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
459424004329	HIGH motif; other site
459424004330	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
459424004331	active site
459424004332	KMSKS motif; other site
459424004333	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
459424004334	Nitronate monooxygenase; Region: NMO; pfam03060
459424004335	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
459424004336	FMN binding site [chemical binding]; other site
459424004337	substrate binding site [chemical binding]; other site
459424004338	putative catalytic residue [active]
459424004339	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
459424004340	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424004341	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004342	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004343	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004344	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
459424004345	Transcriptional regulator [Transcription]; Region: IclR; COG1414
459424004346	Bacterial transcriptional regulator; Region: IclR; pfam01614
459424004347	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
459424004348	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
459424004349	substrate binding site [chemical binding]; other site
459424004350	ligand binding site [chemical binding]; other site
459424004351	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
459424004352	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
459424004353	substrate binding site [chemical binding]; other site
459424004354	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
459424004355	IHF - DNA interface [nucleotide binding]; other site
459424004356	IHF dimer interface [polypeptide binding]; other site
459424004357	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
459424004358	active site
459424004359	Ap6A binding site [chemical binding]; other site
459424004360	nudix motif; other site
459424004361	metal binding site [ion binding]; metal-binding site
459424004362	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424004363	catalytic core [active]
459424004364	polyphosphate kinase; Provisional; Region: PRK05443
459424004365	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
459424004366	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
459424004367	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
459424004368	putative domain interface [polypeptide binding]; other site
459424004369	putative active site [active]
459424004370	catalytic site [active]
459424004371	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
459424004372	putative active site [active]
459424004373	catalytic site [active]
459424004374	Guanylyl transferase CofC like; Region: CofC; cl17472
459424004375	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
459424004376	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
459424004377	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
459424004378	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
459424004379	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
459424004380	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
459424004381	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
459424004382	thiamine monophosphate kinase; Provisional; Region: PRK05731
459424004383	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
459424004384	ATP binding site [chemical binding]; other site
459424004385	dimerization interface [polypeptide binding]; other site
459424004386	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
459424004387	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
459424004388	ligand binding site [chemical binding]; other site
459424004389	active site
459424004390	UGI interface [polypeptide binding]; other site
459424004391	catalytic site [active]
459424004392	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
459424004393	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
459424004394	putative NAD(P) binding site [chemical binding]; other site
459424004395	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
459424004396	putative FMN binding site [chemical binding]; other site
459424004397	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
459424004398	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
459424004399	DAK2 domain; Region: Dak2; cl03685
459424004400	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
459424004401	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
459424004402	generic binding surface II; other site
459424004403	ssDNA binding site; other site
459424004404	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
459424004405	ATP binding site [chemical binding]; other site
459424004406	putative Mg++ binding site [ion binding]; other site
459424004407	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
459424004408	nucleotide binding region [chemical binding]; other site
459424004409	ATP-binding site [chemical binding]; other site
459424004410	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
459424004411	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
459424004412	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
459424004413	active site
459424004414	catalytic tetrad [active]
459424004415	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424004416	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
459424004417	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
459424004418	catalytic residues [active]
459424004419	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
459424004420	putative active site [active]
459424004421	redox center [active]
459424004422	pyruvate carboxylase; Reviewed; Region: PRK12999
459424004423	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
459424004424	ATP-grasp domain; Region: ATP-grasp_4; cl17255
459424004425	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
459424004426	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
459424004427	active site
459424004428	catalytic residues [active]
459424004429	metal binding site [ion binding]; metal-binding site
459424004430	homodimer binding site [polypeptide binding]; other site
459424004431	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
459424004432	carboxyltransferase (CT) interaction site; other site
459424004433	biotinylation site [posttranslational modification]; other site
459424004434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424004435	S-adenosylmethionine binding site [chemical binding]; other site
459424004436	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
459424004437	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
459424004438	active site
459424004439	(T/H)XGH motif; other site
459424004440	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
459424004441	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
459424004442	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
459424004443	putative active site [active]
459424004444	putative substrate binding site [chemical binding]; other site
459424004445	putative cosubstrate binding site; other site
459424004446	catalytic site [active]
459424004447	Predicted permease; Region: DUF318; pfam03773
459424004448	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
459424004449	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
459424004450	active site
459424004451	TDP-binding site; other site
459424004452	acceptor substrate-binding pocket; other site
459424004453	Methyltransferase domain; Region: Methyltransf_24; pfam13578
459424004454	Uncharacterized conserved protein [Function unknown]; Region: COG3268
459424004455	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
459424004456	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424004457	acyl-CoA synthetase; Validated; Region: PRK05850
459424004458	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424004459	acyl-activating enzyme (AAE) consensus motif; other site
459424004460	active site
459424004461	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
459424004462	acyl-CoA synthetase; Validated; Region: PRK06060
459424004463	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424004464	acyl-activating enzyme (AAE) consensus motif; other site
459424004465	AMP binding site [chemical binding]; other site
459424004466	active site
459424004467	CoA binding site [chemical binding]; other site
459424004468	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424004469	Erythronolide synthase docking; Region: Docking; pfam08990
459424004470	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424004471	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424004472	active site
459424004473	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424004474	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424004475	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424004476	Enoylreductase; Region: PKS_ER; smart00829
459424004477	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424004478	NAD(P) binding site [chemical binding]; other site
459424004479	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424004480	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424004481	putative NADP binding site [chemical binding]; other site
459424004482	active site
459424004483	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424004484	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
459424004485	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
459424004486	acyl-CoA synthetase; Validated; Region: PRK05850
459424004487	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424004488	acyl-activating enzyme (AAE) consensus motif; other site
459424004489	active site
459424004490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424004491	S-adenosylmethionine binding site [chemical binding]; other site
459424004492	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004493	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004494	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004495	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424004496	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424004497	active site
459424004498	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
459424004499	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424004500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424004501	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424004502	Enoylreductase; Region: PKS_ER; smart00829
459424004503	NAD(P) binding site [chemical binding]; other site
459424004504	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
459424004505	KR domain; Region: KR; pfam08659
459424004506	putative NADP binding site [chemical binding]; other site
459424004507	active site
459424004508	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424004509	acyltransferase PapA5; Provisional; Region: PRK09294
459424004510	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
459424004511	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
459424004512	ABC-2 type transporter; Region: ABC2_membrane; cl17235
459424004513	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
459424004514	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424004515	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
459424004516	Walker A/P-loop; other site
459424004517	ATP binding site [chemical binding]; other site
459424004518	Q-loop/lid; other site
459424004519	ABC transporter signature motif; other site
459424004520	Walker B; other site
459424004521	D-loop; other site
459424004522	H-loop/switch region; other site
459424004523	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424004524	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424004525	active site
459424004526	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424004527	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424004528	Condensation domain; Region: Condensation; pfam00668
459424004529	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
459424004530	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424004531	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424004532	active site
459424004533	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424004534	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424004535	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
459424004536	KR domain; Region: KR; pfam08659
459424004537	putative NADP binding site [chemical binding]; other site
459424004538	active site
459424004539	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424004540	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424004541	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424004542	active site
459424004543	Acyl transferase domain; Region: Acyl_transf_1; cl08282
459424004544	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424004545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424004546	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424004547	Enoylreductase; Region: PKS_ER; smart00829
459424004548	NAD(P) binding site [chemical binding]; other site
459424004549	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
459424004550	KR domain; Region: KR; pfam08659
459424004551	putative NADP binding site [chemical binding]; other site
459424004552	active site
459424004553	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424004554	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424004555	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
459424004556	active site
459424004557	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424004558	Acyl transferase domain; Region: Acyl_transf_1; cl08282
459424004559	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
459424004560	KR domain; Region: KR; pfam08659
459424004561	NADP binding site [chemical binding]; other site
459424004562	active site
459424004563	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424004564	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424004565	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424004566	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
459424004567	active site
459424004568	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424004569	Acyl transferase domain; Region: Acyl_transf_1; cl08282
459424004570	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
459424004571	KR domain; Region: KR; pfam08659
459424004572	NADP binding site [chemical binding]; other site
459424004573	active site
459424004574	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424004575	acyl-CoA synthetase; Validated; Region: PRK05850
459424004576	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424004577	acyl-activating enzyme (AAE) consensus motif; other site
459424004578	active site
459424004579	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
459424004580	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
459424004581	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
459424004582	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
459424004583	ribonuclease III; Reviewed; Region: rnc; PRK00102
459424004584	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
459424004585	dimerization interface [polypeptide binding]; other site
459424004586	active site
459424004587	metal binding site [ion binding]; metal-binding site
459424004588	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
459424004589	dsRNA binding site [nucleotide binding]; other site
459424004590	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
459424004591	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
459424004592	DNA binding site [nucleotide binding]
459424004593	catalytic residue [active]
459424004594	H2TH interface [polypeptide binding]; other site
459424004595	putative catalytic residues [active]
459424004596	turnover-facilitating residue; other site
459424004597	intercalation triad [nucleotide binding]; other site
459424004598	8OG recognition residue [nucleotide binding]; other site
459424004599	putative reading head residues; other site
459424004600	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
459424004601	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
459424004602	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
459424004603	acylphosphatase; Provisional; Region: PRK14422
459424004604	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
459424004605	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
459424004606	Walker A/P-loop; other site
459424004607	ATP binding site [chemical binding]; other site
459424004608	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
459424004609	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
459424004610	ABC transporter signature motif; other site
459424004611	Walker B; other site
459424004612	D-loop; other site
459424004613	H-loop/switch region; other site
459424004614	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
459424004615	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
459424004616	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
459424004617	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
459424004618	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
459424004619	Nitrogen regulatory protein P-II; Region: P-II; smart00938
459424004620	PII uridylyl-transferase; Provisional; Region: PRK03381
459424004621	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
459424004622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
459424004623	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
459424004624	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
459424004625	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
459424004626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
459424004627	ATP binding site [chemical binding]; other site
459424004628	putative Mg++ binding site [ion binding]; other site
459424004629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
459424004630	ATP-binding site [chemical binding]; other site
459424004631	signal recognition particle protein; Provisional; Region: PRK10867
459424004632	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
459424004633	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
459424004634	P loop; other site
459424004635	GTP binding site [chemical binding]; other site
459424004636	Signal peptide binding domain; Region: SRP_SPB; pfam02978
459424004637	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
459424004638	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
459424004639	active site
459424004640	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
459424004641	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424004642	active site
459424004643	substrate binding site [chemical binding]; other site
459424004644	ATP binding site [chemical binding]; other site
459424004645	activation loop (A-loop); other site
459424004646	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424004647	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424004648	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
459424004649	SnoaL-like domain; Region: SnoaL_4; pfam13577
459424004650	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
459424004651	hypothetical protein; Provisional; Region: PRK02821
459424004652	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
459424004653	G-X-X-G motif; other site
459424004654	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
459424004655	RimM N-terminal domain; Region: RimM; pfam01782
459424004656	PRC-barrel domain; Region: PRC; pfam05239
459424004657	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
459424004658	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
459424004659	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
459424004660	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
459424004661	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
459424004662	Catalytic site [active]
459424004663	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
459424004664	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
459424004665	RNA/DNA hybrid binding site [nucleotide binding]; other site
459424004666	active site
459424004667	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
459424004668	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424004669	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424004670	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424004671	NAD(P) binding site [chemical binding]; other site
459424004672	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424004673	active site
459424004674	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
459424004675	hypothetical protein; Reviewed; Region: PRK12497
459424004676	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
459424004677	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
459424004678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424004679	Walker A motif; other site
459424004680	ATP binding site [chemical binding]; other site
459424004681	Walker B motif; other site
459424004682	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
459424004683	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
459424004684	DNA protecting protein DprA; Region: dprA; TIGR00732
459424004685	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
459424004686	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
459424004687	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
459424004688	FAD binding pocket [chemical binding]; other site
459424004689	FAD binding motif [chemical binding]; other site
459424004690	phosphate binding motif [ion binding]; other site
459424004691	NAD binding pocket [chemical binding]; other site
459424004692	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
459424004693	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
459424004694	putative active site [active]
459424004695	putative substrate binding site [chemical binding]; other site
459424004696	putative FMN binding site [chemical binding]; other site
459424004697	putative catalytic residues [active]
459424004698	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
459424004699	Peptidase family M23; Region: Peptidase_M23; pfam01551
459424004700	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
459424004701	rRNA interaction site [nucleotide binding]; other site
459424004702	S8 interaction site; other site
459424004703	putative laminin-1 binding site; other site
459424004704	elongation factor Ts; Provisional; Region: tsf; PRK09377
459424004705	UBA/TS-N domain; Region: UBA; pfam00627
459424004706	Elongation factor TS; Region: EF_TS; pfam00889
459424004707	Elongation factor TS; Region: EF_TS; pfam00889
459424004708	amidase; Provisional; Region: PRK07869
459424004709	Amidase; Region: Amidase; pfam01425
459424004710	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424004711	MarR family; Region: MarR; pfam01047
459424004712	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
459424004713	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424004714	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
459424004715	putative acyl-acceptor binding pocket; other site
459424004716	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424004717	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424004718	DNA binding site [nucleotide binding]
459424004719	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004720	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004721	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004722	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
459424004723	putative nucleotide binding site [chemical binding]; other site
459424004724	uridine monophosphate binding site [chemical binding]; other site
459424004725	homohexameric interface [polypeptide binding]; other site
459424004726	ribosome recycling factor; Reviewed; Region: frr; PRK00083
459424004727	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
459424004728	hinge region; other site
459424004729	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
459424004730	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
459424004731	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
459424004732	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424004733	FeS/SAM binding site; other site
459424004734	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
459424004735	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
459424004736	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
459424004737	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
459424004738	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
459424004739	Fasciclin domain; Region: Fasciclin; pfam02469
459424004740	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
459424004741	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
459424004742	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
459424004743	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
459424004744	catalytic residues [active]
459424004745	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
459424004746	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
459424004747	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
459424004748	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
459424004749	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
459424004750	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
459424004751	active site
459424004752	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
459424004753	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
459424004754	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
459424004755	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
459424004756	Predicted acetyltransferase [General function prediction only]; Region: COG3393
459424004757	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
459424004758	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
459424004759	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
459424004760	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
459424004761	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
459424004762	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
459424004763	active site
459424004764	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424004765	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
459424004766	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
459424004767	catalytic triad [active]
459424004768	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424004769	PPE family; Region: PPE; pfam00823
459424004770	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424004771	PPE family; Region: PPE; pfam00823
459424004772	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424004773	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424004774	PPE family; Region: PPE; pfam00823
459424004775	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424004776	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004777	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004778	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004779	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004780	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004781	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004782	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
459424004783	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
459424004784	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
459424004785	HupF/HypC family; Region: HupF_HypC; pfam01455
459424004786	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
459424004787	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
459424004788	dimerization interface [polypeptide binding]; other site
459424004789	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
459424004790	ATP binding site [chemical binding]; other site
459424004791	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
459424004792	HupF/HypC family; Region: HupF_HypC; cl00394
459424004793	HupF/HypC family; Region: HupF_HypC; pfam01455
459424004794	Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068
459424004795	nickel binding site [ion binding]; other site
459424004796	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004797	NifU-like domain; Region: NifU; cl00484
459424004798	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
459424004799	[2Fe-2S] cluster binding site [ion binding]; other site
459424004800	iron-sulfur cluster [ion binding]; other site
459424004801	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
459424004802	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
459424004803	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
459424004804	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004805	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004806	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004807	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
459424004808	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
459424004809	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
459424004810	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
459424004811	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
459424004812	metal binding site 2 [ion binding]; metal-binding site
459424004813	putative DNA binding helix; other site
459424004814	metal binding site 1 [ion binding]; metal-binding site
459424004815	dimer interface [polypeptide binding]; other site
459424004816	structural Zn2+ binding site [ion binding]; other site
459424004817	mycothione reductase; Reviewed; Region: PRK07846
459424004818	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424004819	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424004820	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
459424004821	acyl-CoA synthetase; Validated; Region: PRK05850
459424004822	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424004823	acyl-activating enzyme (AAE) consensus motif; other site
459424004824	active site
459424004825	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424004826	Thioesterase; Region: PKS_TE; smart00824
459424004827	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424004828	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004829	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424004831	putative substrate translocation pore; other site
459424004832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424004833	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
459424004834	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424004835	malate:quinone oxidoreductase; Validated; Region: PRK05257
459424004836	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
459424004837	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
459424004838	Coenzyme A binding pocket [chemical binding]; other site
459424004839	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
459424004840	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
459424004841	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
459424004842	metal ion-dependent adhesion site (MIDAS); other site
459424004843	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
459424004844	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
459424004845	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
459424004846	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
459424004847	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
459424004848	catalytic triad [active]
459424004849	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
459424004850	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
459424004851	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
459424004852	active site
459424004853	SAM binding site [chemical binding]; other site
459424004854	homodimer interface [polypeptide binding]; other site
459424004855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424004856	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424004857	putative substrate translocation pore; other site
459424004858	prolyl-tRNA synthetase; Provisional; Region: PRK09194
459424004859	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
459424004860	dimer interface [polypeptide binding]; other site
459424004861	motif 1; other site
459424004862	active site
459424004863	motif 2; other site
459424004864	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
459424004865	putative deacylase active site [active]
459424004866	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
459424004867	active site
459424004868	motif 3; other site
459424004869	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
459424004870	anticodon binding site; other site
459424004871	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
459424004872	dinuclear metal binding motif [ion binding]; other site
459424004873	ribosome maturation protein RimP; Reviewed; Region: PRK00092
459424004874	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
459424004875	putative oligomer interface [polypeptide binding]; other site
459424004876	putative RNA binding site [nucleotide binding]; other site
459424004877	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
459424004878	NusA N-terminal domain; Region: NusA_N; pfam08529
459424004879	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
459424004880	RNA binding site [nucleotide binding]; other site
459424004881	homodimer interface [polypeptide binding]; other site
459424004882	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
459424004883	G-X-X-G motif; other site
459424004884	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
459424004885	G-X-X-G motif; other site
459424004886	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
459424004887	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
459424004888	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
459424004889	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
459424004890	G1 box; other site
459424004891	putative GEF interaction site [polypeptide binding]; other site
459424004892	GTP/Mg2+ binding site [chemical binding]; other site
459424004893	Switch I region; other site
459424004894	G2 box; other site
459424004895	G3 box; other site
459424004896	Switch II region; other site
459424004897	G4 box; other site
459424004898	G5 box; other site
459424004899	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
459424004900	Translation-initiation factor 2; Region: IF-2; pfam11987
459424004901	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
459424004902	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
459424004903	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
459424004904	DHH family; Region: DHH; pfam01368
459424004905	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
459424004906	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
459424004907	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004908	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004909	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004910	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004911	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424004912	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424004913	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
459424004914	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
459424004915	Walker A/P-loop; other site
459424004916	ATP binding site [chemical binding]; other site
459424004917	Q-loop/lid; other site
459424004918	ABC transporter signature motif; other site
459424004919	Walker B; other site
459424004920	D-loop; other site
459424004921	H-loop/switch region; other site
459424004922	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
459424004923	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
459424004924	enoyl-CoA hydratase; Provisional; Region: PRK06190
459424004925	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424004926	substrate binding site [chemical binding]; other site
459424004927	oxyanion hole (OAH) forming residues; other site
459424004928	trimer interface [polypeptide binding]; other site
459424004929	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424004930	PPE family; Region: PPE; pfam00823
459424004931	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424004932	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424004933	PPE family; Region: PPE; pfam00823
459424004934	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424004935	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
459424004936	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
459424004937	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
459424004938	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
459424004939	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
459424004940	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
459424004941	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
459424004942	Predicted acyl esterases [General function prediction only]; Region: COG2936
459424004943	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424004944	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
459424004945	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
459424004946	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
459424004947	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
459424004948	active site
459424004949	metal binding site [ion binding]; metal-binding site
459424004950	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
459424004951	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
459424004952	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
459424004953	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
459424004954	RNA binding site [nucleotide binding]; other site
459424004955	active site
459424004956	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
459424004957	lipid-transfer protein; Provisional; Region: PRK08256
459424004958	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424004959	active site
459424004960	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424004961	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424004962	active site
459424004963	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
459424004964	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424004965	putative DNA binding site [nucleotide binding]; other site
459424004966	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
459424004967	FeoA domain; Region: FeoA; pfam04023
459424004968	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
459424004969	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
459424004970	active site
459424004971	Riboflavin kinase; Region: Flavokinase; pfam01687
459424004972	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
459424004973	16S/18S rRNA binding site [nucleotide binding]; other site
459424004974	S13e-L30e interaction site [polypeptide binding]; other site
459424004975	25S rRNA binding site [nucleotide binding]; other site
459424004976	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
459424004977	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
459424004978	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
459424004979	oligomer interface [polypeptide binding]; other site
459424004980	RNA binding site [nucleotide binding]; other site
459424004981	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
459424004982	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
459424004983	RNase E interface [polypeptide binding]; other site
459424004984	trimer interface [polypeptide binding]; other site
459424004985	active site
459424004986	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
459424004987	putative nucleic acid binding region [nucleotide binding]; other site
459424004988	G-X-X-G motif; other site
459424004989	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
459424004990	RNA binding site [nucleotide binding]; other site
459424004991	domain interface; other site
459424004992	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
459424004993	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
459424004994	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
459424004995	Nitronate monooxygenase; Region: NMO; pfam03060
459424004996	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
459424004997	FMN binding site [chemical binding]; other site
459424004998	substrate binding site [chemical binding]; other site
459424004999	putative catalytic residue [active]
459424005000	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
459424005001	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
459424005002	hexamer interface [polypeptide binding]; other site
459424005003	ligand binding site [chemical binding]; other site
459424005004	putative active site [active]
459424005005	NAD(P) binding site [chemical binding]; other site
459424005006	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424005007	putative DNA binding site [nucleotide binding]; other site
459424005008	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
459424005009	putative Zn2+ binding site [ion binding]; other site
459424005010	AsnC family; Region: AsnC_trans_reg; pfam01037
459424005011	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
459424005012	hydrophobic ligand binding site; other site
459424005013	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
459424005014	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
459424005015	short chain dehydrogenase; Validated; Region: PRK05855
459424005016	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424005017	classical (c) SDRs; Region: SDR_c; cd05233
459424005018	NAD(P) binding site [chemical binding]; other site
459424005019	active site
459424005020	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
459424005021	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
459424005022	FMN-binding pocket [chemical binding]; other site
459424005023	flavin binding motif; other site
459424005024	phosphate binding motif [ion binding]; other site
459424005025	beta-alpha-beta structure motif; other site
459424005026	NAD binding pocket [chemical binding]; other site
459424005027	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424005028	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
459424005029	catalytic loop [active]
459424005030	iron binding site [ion binding]; other site
459424005031	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424005032	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
459424005033	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
459424005034	[2Fe-2S] cluster binding site [ion binding]; other site
459424005035	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
459424005036	hydrophobic ligand binding site; other site
459424005037	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
459424005038	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
459424005039	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424005040	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424005041	active site
459424005042	dihydrodipicolinate reductase; Provisional; Region: PRK00048
459424005043	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
459424005044	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
459424005045	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
459424005046	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
459424005047	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005048	PPE family; Region: PPE; pfam00823
459424005049	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424005050	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
459424005051	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424005052	acyl-activating enzyme (AAE) consensus motif; other site
459424005053	AMP binding site [chemical binding]; other site
459424005054	active site
459424005055	CoA binding site [chemical binding]; other site
459424005056	PE family; Region: PE; pfam00934
459424005057	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424005058	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
459424005059	classical (c) SDRs; Region: SDR_c; cd05233
459424005060	NAD(P) binding site [chemical binding]; other site
459424005061	active site
459424005062	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424005063	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424005064	active site
459424005065	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424005066	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424005067	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424005068	active site
459424005069	Dienelactone hydrolase family; Region: DLH; pfam01738
459424005070	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424005071	thymidylate synthase; Reviewed; Region: thyA; PRK01827
459424005072	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
459424005073	dimerization interface [polypeptide binding]; other site
459424005074	active site
459424005075	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
459424005076	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
459424005077	folate binding site [chemical binding]; other site
459424005078	NADP+ binding site [chemical binding]; other site
459424005079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
459424005080	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
459424005081	HsdM N-terminal domain; Region: HsdM_N; pfam12161
459424005082	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
459424005083	Methyltransferase domain; Region: Methyltransf_26; pfam13659
459424005084	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
459424005085	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
459424005086	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
459424005087	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
459424005088	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
459424005089	dimer interface [polypeptide binding]; other site
459424005090	active site
459424005091	catalytic residue [active]
459424005092	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
459424005093	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
459424005094	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
459424005095	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424005096	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424005097	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
459424005098	classical (c) SDRs; Region: SDR_c; cd05233
459424005099	NAD(P) binding site [chemical binding]; other site
459424005100	active site
459424005101	Uncharacterized conserved protein [Function unknown]; Region: COG1359
459424005102	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
459424005103	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
459424005104	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424005105	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
459424005106	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424005107	Coenzyme A binding pocket [chemical binding]; other site
459424005108	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
459424005109	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424005110	non-specific DNA binding site [nucleotide binding]; other site
459424005111	salt bridge; other site
459424005112	sequence-specific DNA binding site [nucleotide binding]; other site
459424005113	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
459424005114	Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858
459424005115	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
459424005116	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
459424005117	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
459424005118	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
459424005119	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
459424005120	recombinase A; Provisional; Region: recA; PRK09354
459424005121	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
459424005122	hexamer interface [polypeptide binding]; other site
459424005123	Walker A motif; other site
459424005124	ATP binding site [chemical binding]; other site
459424005125	Walker B motif; other site
459424005126	recombination regulator RecX; Reviewed; Region: recX; PRK00117
459424005127	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
459424005128	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
459424005129	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424005130	FeS/SAM binding site; other site
459424005131	TRAM domain; Region: TRAM; cl01282
459424005132	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
459424005133	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
459424005134	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
459424005135	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424005136	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424005137	active site
459424005138	ATP binding site [chemical binding]; other site
459424005139	substrate binding site [chemical binding]; other site
459424005140	activation loop (A-loop); other site
459424005141	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
459424005142	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
459424005143	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
459424005144	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
459424005145	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
459424005146	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
459424005147	GTPases [General function prediction only]; Region: HflX; COG2262
459424005148	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
459424005149	HflX GTPase family; Region: HflX; cd01878
459424005150	G1 box; other site
459424005151	GTP/Mg2+ binding site [chemical binding]; other site
459424005152	Switch I region; other site
459424005153	G2 box; other site
459424005154	G3 box; other site
459424005155	Switch II region; other site
459424005156	G4 box; other site
459424005157	G5 box; other site
459424005158	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424005159	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424005160	active site
459424005161	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005162	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005163	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005164	LexA repressor; Validated; Region: PRK00215
459424005165	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
459424005166	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
459424005167	Catalytic site [active]
459424005168	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
459424005169	ATP cone domain; Region: ATP-cone; pfam03477
459424005170	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
459424005171	heme-binding site [chemical binding]; other site
459424005172	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
459424005173	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424005174	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
459424005175	PAC2 family; Region: PAC2; pfam09754
459424005176	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
459424005177	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
459424005178	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424005179	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424005180	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
459424005181	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005182	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005183	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005184	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
459424005185	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
459424005186	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
459424005187	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
459424005188	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
459424005189	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
459424005190	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424005191	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
459424005192	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424005193	DNA binding residues [nucleotide binding]
459424005194	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
459424005195	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
459424005196	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
459424005197	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
459424005198	homotrimer interaction site [polypeptide binding]; other site
459424005199	putative active site [active]
459424005200	PE family; Region: PE; pfam00934
459424005201	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
459424005202	active site
459424005203	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
459424005204	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424005205	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
459424005206	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424005207	DNA binding residues [nucleotide binding]
459424005208	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
459424005209	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
459424005210	nucleotide binding site [chemical binding]; other site
459424005211	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
459424005212	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
459424005213	active site
459424005214	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
459424005215	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
459424005216	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
459424005217	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
459424005218	trimer interface [polypeptide binding]; other site
459424005219	active site
459424005220	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
459424005221	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
459424005222	generic binding surface II; other site
459424005223	ssDNA binding site; other site
459424005224	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
459424005225	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
459424005226	TrkA-N domain; Region: TrkA_N; pfam02254
459424005227	TrkA-C domain; Region: TrkA_C; pfam02080
459424005228	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
459424005229	TrkA-N domain; Region: TrkA_N; pfam02254
459424005230	TrkA-C domain; Region: TrkA_C; pfam02080
459424005231	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
459424005232	TRAM domain; Region: TRAM; cl01282
459424005233	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
459424005234	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
459424005235	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
459424005236	transmembrane helices; other site
459424005237	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
459424005238	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
459424005239	transmembrane helices; other site
459424005240	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
459424005241	FOG: CBS domain [General function prediction only]; Region: COG0517
459424005242	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
459424005243	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
459424005244	TPP-binding site; other site
459424005245	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
459424005246	PYR/PP interface [polypeptide binding]; other site
459424005247	dimer interface [polypeptide binding]; other site
459424005248	TPP binding site [chemical binding]; other site
459424005249	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
459424005250	PE family; Region: PE; pfam00934
459424005251	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
459424005252	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
459424005253	catalytic site [active]
459424005254	putative active site [active]
459424005255	putative substrate binding site [chemical binding]; other site
459424005256	Helicase and RNase D C-terminal; Region: HRDC; smart00341
459424005257	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
459424005258	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
459424005259	substrate binding site [chemical binding]; other site
459424005260	active site
459424005261	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
459424005262	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424005263	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424005264	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
459424005265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424005266	Methyltransferase domain; Region: Methyltransf_31; pfam13847
459424005267	S-adenosylmethionine binding site [chemical binding]; other site
459424005268	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
459424005269	SelR domain; Region: SelR; pfam01641
459424005270	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
459424005271	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424005272	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424005273	hypothetical protein; Provisional; Region: PRK14059
459424005274	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
459424005275	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
459424005276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424005277	Coenzyme A binding pocket [chemical binding]; other site
459424005278	Clp protease ATP binding subunit; Region: clpC; CHL00095
459424005279	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424005280	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424005281	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424005282	TPR repeat; Region: TPR_11; pfam13414
459424005283	Tetratricopeptide repeat; Region: TPR_2; pfam07719
459424005284	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
459424005285	binding surface
459424005286	TPR motif; other site
459424005287	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
459424005288	PE family; Region: PE; pfam00934
459424005289	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005290	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005291	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005292	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005293	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005294	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005295	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424005296	dimerization interface [polypeptide binding]; other site
459424005297	putative DNA binding site [nucleotide binding]; other site
459424005298	putative Zn2+ binding site [ion binding]; other site
459424005299	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
459424005300	active site
459424005301	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424005302	putative DNA binding site [nucleotide binding]; other site
459424005303	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
459424005304	putative heme binding pocket [chemical binding]; other site
459424005305	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
459424005306	anti sigma factor interaction site; other site
459424005307	regulatory phosphorylation site [posttranslational modification]; other site
459424005308	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424005309	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424005310	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
459424005311	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
459424005312	acyl-CoA synthetase; Validated; Region: PRK07798
459424005313	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424005314	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
459424005315	acyl-activating enzyme (AAE) consensus motif; other site
459424005316	acyl-activating enzyme (AAE) consensus motif; other site
459424005317	putative AMP binding site [chemical binding]; other site
459424005318	putative active site [active]
459424005319	putative CoA binding site [chemical binding]; other site
459424005320	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005321	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005322	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005323	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
459424005324	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
459424005325	P loop; other site
459424005326	Nucleotide binding site [chemical binding]; other site
459424005327	DTAP/Switch II; other site
459424005328	Switch I; other site
459424005329	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
459424005330	Magnesium ion binding site [ion binding]; other site
459424005331	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
459424005332	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
459424005333	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
459424005334	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
459424005335	RNA binding surface [nucleotide binding]; other site
459424005336	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
459424005337	active site
459424005338	cytidylate kinase; Provisional; Region: cmk; PRK00023
459424005339	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
459424005340	CMP-binding site; other site
459424005341	The sites determining sugar specificity; other site
459424005342	GTP-binding protein Der; Reviewed; Region: PRK03003
459424005343	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
459424005344	G1 box; other site
459424005345	GTP/Mg2+ binding site [chemical binding]; other site
459424005346	Switch I region; other site
459424005347	G2 box; other site
459424005348	Switch II region; other site
459424005349	G3 box; other site
459424005350	G4 box; other site
459424005351	G5 box; other site
459424005352	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
459424005353	G1 box; other site
459424005354	GTP/Mg2+ binding site [chemical binding]; other site
459424005355	Switch I region; other site
459424005356	G2 box; other site
459424005357	G3 box; other site
459424005358	Switch II region; other site
459424005359	G4 box; other site
459424005360	G5 box; other site
459424005361	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
459424005362	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
459424005363	catalytic residues [active]
459424005364	Recombinase; Region: Recombinase; pfam07508
459424005365	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
459424005366	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005367	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005368	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005369	putative phiMU02 phage
459424005370	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005371	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005372	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005373	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005374	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
459424005375	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
459424005376	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
459424005377	TatD related DNase; Region: TatD_DNase; pfam01026
459424005378	active site
459424005379	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005380	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005381	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005382	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424005383	dimerization interface [polypeptide binding]; other site
459424005384	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424005385	cyclase homology domain; Region: CHD; cd07302
459424005386	nucleotidyl binding site; other site
459424005387	metal binding site [ion binding]; metal-binding site
459424005388	dimer interface [polypeptide binding]; other site
459424005389	3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474
459424005390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424005391	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
459424005392	active site
459424005393	catalytic residues [active]
459424005394	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
459424005395	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
459424005396	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424005397	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
459424005398	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
459424005399	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424005400	DNA-binding site [nucleotide binding]; DNA binding site
459424005401	UTRA domain; Region: UTRA; pfam07702
459424005402	Uncharacterized conserved protein [Function unknown]; Region: COG1359
459424005403	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
459424005404	homotrimer interaction site [polypeptide binding]; other site
459424005405	putative active site [active]
459424005406	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
459424005407	substrate binding pocket [chemical binding]; other site
459424005408	substrate-Mg2+ binding site; other site
459424005409	aspartate-rich region 1; other site
459424005410	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424005411	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
459424005412	homodimer interface [polypeptide binding]; other site
459424005413	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
459424005414	active site pocket [active]
459424005415	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
459424005416	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
459424005417	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
459424005418	NAD(P) binding site [chemical binding]; other site
459424005419	catalytic residues [active]
459424005420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424005421	putative substrate translocation pore; other site
459424005422	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
459424005423	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424005424	PE family; Region: PE; pfam00934
459424005425	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
459424005426	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
459424005427	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
459424005428	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424005429	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
459424005430	amino acid transporter; Region: 2A0306; TIGR00909
459424005431	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424005432	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424005433	active site
459424005434	ATP binding site [chemical binding]; other site
459424005435	substrate binding site [chemical binding]; other site
459424005436	activation loop (A-loop); other site
459424005437	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
459424005438	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
459424005439	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
459424005440	TrkA-C domain; Region: TrkA_C; pfam02080
459424005441	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
459424005442	TrkA-N domain; Region: TrkA_N; pfam02254
459424005443	TrkA-C domain; Region: TrkA_C; pfam02080
459424005444	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
459424005445	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
459424005446	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
459424005447	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
459424005448	RNA binding site [nucleotide binding]; other site
459424005449	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
459424005450	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
459424005451	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
459424005452	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
459424005453	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
459424005454	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
459424005455	putative FPP binding hydrophobic cleft; other site
459424005456	dimer interface [polypeptide binding]; other site
459424005457	putative IPP diphosphate binding site; other site
459424005458	NYN domain; Region: NYN; pfam01936
459424005459	putative metal binding site [ion binding]; other site
459424005460	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
459424005461	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005462	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005463	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005464	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
459424005465	classical (c) SDRs; Region: SDR_c; cd05233
459424005466	NAD(P) binding site [chemical binding]; other site
459424005467	active site
459424005468	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
459424005469	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
459424005470	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
459424005471	PE family; Region: PE; pfam00934
459424005472	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
459424005473	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424005474	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
459424005475	acyl-activating enzyme (AAE) consensus motif; other site
459424005476	acyl-activating enzyme (AAE) consensus motif; other site
459424005477	putative AMP binding site [chemical binding]; other site
459424005478	putative active site [active]
459424005479	putative CoA binding site [chemical binding]; other site
459424005480	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424005481	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424005482	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424005483	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424005484	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
459424005485	classical (c) SDRs; Region: SDR_c; cd05233
459424005486	short chain dehydrogenase; Provisional; Region: PRK07832
459424005487	NAD(P) binding site [chemical binding]; other site
459424005488	active site
459424005489	Cupin domain; Region: Cupin_2; cl17218
459424005490	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
459424005491	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424005492	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424005493	active site
459424005494	ATP binding site [chemical binding]; other site
459424005495	substrate binding site [chemical binding]; other site
459424005496	activation loop (A-loop); other site
459424005497	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005498	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005499	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005500	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
459424005501	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
459424005502	tetrameric interface [polypeptide binding]; other site
459424005503	NAD binding site [chemical binding]; other site
459424005504	catalytic residues [active]
459424005505	substrate binding site [chemical binding]; other site
459424005506	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424005507	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424005508	phosphopeptide binding site; other site
459424005509	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424005510	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424005511	phosphopeptide binding site; other site
459424005512	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
459424005513	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
459424005514	Walker A/P-loop; other site
459424005515	ATP binding site [chemical binding]; other site
459424005516	Q-loop/lid; other site
459424005517	ABC transporter signature motif; other site
459424005518	Walker B; other site
459424005519	D-loop; other site
459424005520	H-loop/switch region; other site
459424005521	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
459424005522	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
459424005523	Peptidase family M48; Region: Peptidase_M48; pfam01435
459424005524	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
459424005525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424005526	Coenzyme A binding pocket [chemical binding]; other site
459424005527	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
459424005528	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
459424005529	acyl-activating enzyme (AAE) consensus motif; other site
459424005530	putative AMP binding site [chemical binding]; other site
459424005531	putative active site [active]
459424005532	putative CoA binding site [chemical binding]; other site
459424005533	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
459424005534	intersubunit interface [polypeptide binding]; other site
459424005535	active site
459424005536	Zn2+ binding site [ion binding]; other site
459424005537	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424005538	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
459424005539	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424005540	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424005541	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424005542	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424005543	short chain dehydrogenase; Provisional; Region: PRK08267
459424005544	classical (c) SDRs; Region: SDR_c; cd05233
459424005545	NAD(P) binding site [chemical binding]; other site
459424005546	active site
459424005547	acyl-CoA synthetase; Provisional; Region: PRK13388
459424005548	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424005549	acyl-activating enzyme (AAE) consensus motif; other site
459424005550	AMP binding site [chemical binding]; other site
459424005551	active site
459424005552	CoA binding site [chemical binding]; other site
459424005553	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
459424005554	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424005555	hypothetical protein; Provisional; Region: PRK06185
459424005556	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424005557	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
459424005558	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
459424005559	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424005560	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
459424005561	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
459424005562	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424005563	Cytochrome P450; Region: p450; cl12078
459424005564	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
459424005565	classical (c) SDRs; Region: SDR_c; cd05233
459424005566	NAD(P) binding site [chemical binding]; other site
459424005567	active site
459424005568	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424005569	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424005570	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
459424005571	Uncharacterized conserved protein [Function unknown]; Region: COG0393
459424005572	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
459424005573	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424005574	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424005575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424005576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424005577	S-adenosylmethionine binding site [chemical binding]; other site
459424005578	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
459424005579	catalytic residues [active]
459424005580	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
459424005581	putative homotetramer interface [polypeptide binding]; other site
459424005582	putative homodimer interface [polypeptide binding]; other site
459424005583	putative allosteric switch controlling residues; other site
459424005584	putative metal binding site [ion binding]; other site
459424005585	putative homodimer-homodimer interface [polypeptide binding]; other site
459424005586	Domain of unknown function DUF302; Region: DUF302; pfam03625
459424005587	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
459424005588	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
459424005589	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
459424005590	dimer interface [polypeptide binding]; other site
459424005591	active site
459424005592	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
459424005593	substrate binding site [chemical binding]; other site
459424005594	catalytic residue [active]
459424005595	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
459424005596	Peptidase family M28; Region: Peptidase_M28; pfam04389
459424005597	metal binding site [ion binding]; metal-binding site
459424005598	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
459424005599	FAD binding domain; Region: FAD_binding_4; pfam01565
459424005600	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
459424005601	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005602	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005603	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005604	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005605	PPE family; Region: PPE; pfam00823
459424005606	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424005607	PE family; Region: PE; pfam00934
459424005608	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424005609	Cytochrome P450; Region: p450; cl12078
459424005610	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005611	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005612	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005613	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005614	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005615	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005616	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
459424005617	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
459424005618	Protein of unknown function (DUF690); Region: DUF690; pfam05108
459424005619	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
459424005620	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424005621	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
459424005622	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424005623	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424005624	Cytochrome P450; Region: p450; cl12078
459424005625	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
459424005626	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005627	PPE family; Region: PPE; pfam00823
459424005628	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424005629	PE family; Region: PE; pfam00934
459424005630	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005631	PPE family; Region: PPE; pfam00823
459424005632	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424005633	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424005634	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005635	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005636	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005637	PE family; Region: PE; pfam00934
459424005638	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
459424005639	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
459424005640	EspG family; Region: ESX-1_EspG; pfam14011
459424005641	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
459424005642	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
459424005643	catalytic residues [active]
459424005644	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
459424005645	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
459424005646	active site
459424005647	catalytic residues [active]
459424005648	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
459424005649	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
459424005650	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424005651	Walker A motif; other site
459424005652	ATP binding site [chemical binding]; other site
459424005653	Walker B motif; other site
459424005654	arginine finger; other site
459424005655	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005656	PPE family; Region: PPE; pfam00823
459424005657	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005658	PPE family; Region: PPE; pfam00823
459424005659	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424005660	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005661	PPE family; Region: PPE; pfam00823
459424005662	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005663	PPE family; Region: PPE; pfam00823
459424005664	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424005665	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005666	PPE family; Region: PPE; pfam00823
459424005667	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424005668	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
459424005669	MgtC family; Region: MgtC; pfam02308
459424005670	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
459424005671	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424005672	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424005673	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
459424005674	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
459424005675	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
459424005676	active site
459424005677	metal binding site [ion binding]; metal-binding site
459424005678	hypothetical protein; Validated; Region: PRK07121
459424005679	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
459424005680	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005681	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005682	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005683	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
459424005684	ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472
459424005685	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
459424005686	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005687	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005688	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005689	hypothetical protein; Provisional; Region: PRK05858
459424005690	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
459424005691	PYR/PP interface [polypeptide binding]; other site
459424005692	dimer interface [polypeptide binding]; other site
459424005693	TPP binding site [chemical binding]; other site
459424005694	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
459424005695	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
459424005696	TPP-binding site; other site
459424005697	dimer interface [polypeptide binding]; other site
459424005698	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
459424005699	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
459424005700	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
459424005701	nucleotide binding region [chemical binding]; other site
459424005702	ATP-binding site [chemical binding]; other site
459424005703	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
459424005704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
459424005705	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
459424005706	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
459424005707	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
459424005708	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
459424005709	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
459424005710	lipoyl attachment site [posttranslational modification]; other site
459424005711	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424005712	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424005713	phosphopeptide binding site; other site
459424005714	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
459424005715	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
459424005716	DNA binding residues [nucleotide binding]
459424005717	Bifunctional nuclease; Region: DNase-RNase; pfam02577
459424005718	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
459424005719	DNA binding residues [nucleotide binding]
459424005720	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
459424005721	putative dimer interface [polypeptide binding]; other site
459424005722	glycine dehydrogenase; Provisional; Region: PRK05367
459424005723	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
459424005724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424005725	tetramer interface [polypeptide binding]; other site
459424005726	catalytic residue [active]
459424005727	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
459424005728	tetramer interface [polypeptide binding]; other site
459424005729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424005730	catalytic residue [active]
459424005731	PE family; Region: PE; pfam00934
459424005732	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005733	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005734	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005735	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424005736	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
459424005737	metal ion-dependent adhesion site (MIDAS); other site
459424005738	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
459424005739	active site
459424005740	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
459424005741	Domain of unknown function DUF21; Region: DUF21; pfam01595
459424005742	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
459424005743	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
459424005744	Domain of unknown function DUF21; Region: DUF21; pfam01595
459424005745	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
459424005746	Transporter associated domain; Region: CorC_HlyC; smart01091
459424005747	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
459424005748	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
459424005749	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
459424005750	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
459424005751	active site
459424005752	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005753	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005754	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005755	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
459424005756	Predicted transcriptional regulator [Transcription]; Region: COG3682
459424005757	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
459424005758	CoenzymeA binding site [chemical binding]; other site
459424005759	subunit interaction site [polypeptide binding]; other site
459424005760	PHB binding site; other site
459424005761	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
459424005762	alpha-gamma subunit interface [polypeptide binding]; other site
459424005763	beta-gamma subunit interface [polypeptide binding]; other site
459424005764	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
459424005765	gamma-beta subunit interface [polypeptide binding]; other site
459424005766	alpha-beta subunit interface [polypeptide binding]; other site
459424005767	urease subunit alpha; Reviewed; Region: ureC; PRK13206
459424005768	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
459424005769	subunit interactions [polypeptide binding]; other site
459424005770	active site
459424005771	flap region; other site
459424005772	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
459424005773	UreF; Region: UreF; pfam01730
459424005774	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
459424005775	UreD urease accessory protein; Region: UreD; cl00530
459424005776	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
459424005777	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424005778	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
459424005779	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424005780	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424005781	classical (c) SDRs; Region: SDR_c; cd05233
459424005782	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
459424005783	NAD(P) binding site [chemical binding]; other site
459424005784	active site
459424005785	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
459424005786	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
459424005787	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
459424005788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424005789	dimer interface [polypeptide binding]; other site
459424005790	conserved gate region; other site
459424005791	putative PBP binding loops; other site
459424005792	ABC-ATPase subunit interface; other site
459424005793	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424005794	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
459424005795	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
459424005796	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
459424005797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424005798	Walker A/P-loop; other site
459424005799	ATP binding site [chemical binding]; other site
459424005800	Q-loop/lid; other site
459424005801	ABC transporter signature motif; other site
459424005802	Walker B; other site
459424005803	D-loop; other site
459424005804	H-loop/switch region; other site
459424005805	TOBE domain; Region: TOBE; pfam03459
459424005806	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
459424005807	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
459424005808	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
459424005809	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
459424005810	NAD(P) binding site [chemical binding]; other site
459424005811	CAAX protease self-immunity; Region: Abi; pfam02517
459424005812	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
459424005813	MOSC domain; Region: MOSC; pfam03473
459424005814	putative phosphoketolase; Provisional; Region: PRK05261
459424005815	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
459424005816	TPP-binding site; other site
459424005817	XFP C-terminal domain; Region: XFP_C; pfam09363
459424005818	short chain dehydrogenase; Provisional; Region: PRK07825
459424005819	classical (c) SDRs; Region: SDR_c; cd05233
459424005820	NAD(P) binding site [chemical binding]; other site
459424005821	active site
459424005822	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
459424005823	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424005824	Coenzyme A binding pocket [chemical binding]; other site
459424005825	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
459424005826	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424005827	active site
459424005828	hypothetical protein; Provisional; Region: PRK12320
459424005829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424005830	NAD(P) binding site [chemical binding]; other site
459424005831	active site
459424005832	Protein of unknown function, DUF606; Region: DUF606; pfam04657
459424005833	Domain of unknown function (DUF385); Region: DUF385; pfam04075
459424005834	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
459424005835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424005836	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
459424005837	Walker A motif; other site
459424005838	ATP binding site [chemical binding]; other site
459424005839	Walker B motif; other site
459424005840	arginine finger; other site
459424005841	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
459424005842	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
459424005843	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
459424005844	active site
459424005845	substrate binding site [chemical binding]; other site
459424005846	FMN binding site [chemical binding]; other site
459424005847	putative catalytic residues [active]
459424005848	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
459424005849	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
459424005850	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
459424005851	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
459424005852	dimer interface [polypeptide binding]; other site
459424005853	decamer (pentamer of dimers) interface [polypeptide binding]; other site
459424005854	catalytic triad [active]
459424005855	peroxidatic and resolving cysteines [active]
459424005856	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
459424005857	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
459424005858	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
459424005859	dimerization interface [polypeptide binding]; other site
459424005860	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
459424005861	enoyl-CoA hydratase; Provisional; Region: PRK06688
459424005862	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424005863	substrate binding site [chemical binding]; other site
459424005864	oxyanion hole (OAH) forming residues; other site
459424005865	trimer interface [polypeptide binding]; other site
459424005866	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
459424005867	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
459424005868	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
459424005869	heme binding site [chemical binding]; other site
459424005870	ferroxidase pore; other site
459424005871	ferroxidase diiron center [ion binding]; other site
459424005872	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
459424005873	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
459424005874	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
459424005875	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424005876	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
459424005877	Amidase; Region: Amidase; cl11426
459424005878	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005879	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005880	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005881	Condensation domain; Region: Condensation; pfam00668
459424005882	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
459424005883	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
459424005884	acyl-activating enzyme (AAE) consensus motif; other site
459424005885	AMP binding site [chemical binding]; other site
459424005886	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424005887	Condensation domain; Region: Condensation; pfam00668
459424005888	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
459424005889	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
459424005890	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
459424005891	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424005892	Cytochrome P450; Region: p450; cl12078
459424005893	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
459424005894	short chain dehydrogenase; Provisional; Region: PRK08267
459424005895	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424005896	NAD(P) binding site [chemical binding]; other site
459424005897	active site
459424005898	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
459424005899	hydrophobic ligand binding site; other site
459424005900	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
459424005901	chorismate mutase; Provisional; Region: PRK09269
459424005902	chorismate mutase, putative; Region: CM_mono2; TIGR01806
459424005903	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424005904	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
459424005905	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424005906	Putative esterase; Region: Esterase; pfam00756
459424005907	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005908	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005909	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005910	YceI-like domain; Region: YceI; pfam04264
459424005911	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
459424005912	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
459424005913	putative NAD(P) binding site [chemical binding]; other site
459424005914	putative substrate binding site [chemical binding]; other site
459424005915	catalytic Zn binding site [ion binding]; other site
459424005916	structural Zn binding site [ion binding]; other site
459424005917	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424005918	Cytochrome P450; Region: p450; cl12078
459424005919	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005920	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005921	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005922	Nitronate monooxygenase; Region: NMO; pfam03060
459424005923	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
459424005924	FMN binding site [chemical binding]; other site
459424005925	substrate binding site [chemical binding]; other site
459424005926	putative catalytic residue [active]
459424005927	PE family; Region: PE; pfam00934
459424005928	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005929	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005930	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005931	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424005932	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424005933	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
459424005934	dimerization interface [polypeptide binding]; other site
459424005935	putative tRNAtyr binding site [nucleotide binding]; other site
459424005936	putative active site [active]
459424005937	Domain of unknown function DUF77; Region: DUF77; pfam01910
459424005938	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
459424005939	putative ADP-ribose binding site [chemical binding]; other site
459424005940	competence damage-inducible protein A; Provisional; Region: PRK00549
459424005941	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
459424005942	putative MPT binding site; other site
459424005943	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
459424005944	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424005945	Predicted membrane protein [Function unknown]; Region: COG1950
459424005946	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
459424005947	anti sigma factor interaction site; other site
459424005948	regulatory phosphorylation site [posttranslational modification]; other site
459424005949	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
459424005950	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424005951	PPE family; Region: PPE; pfam00823
459424005952	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
459424005953	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424005954	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
459424005955	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
459424005956	NAD(P) binding site [chemical binding]; other site
459424005957	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
459424005958	putative hydrophobic ligand binding site [chemical binding]; other site
459424005959	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424005960	dimerization interface [polypeptide binding]; other site
459424005961	putative DNA binding site [nucleotide binding]; other site
459424005962	putative Zn2+ binding site [ion binding]; other site
459424005963	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
459424005964	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
459424005965	tetramer interface [polypeptide binding]; other site
459424005966	active site
459424005967	Mg2+/Mn2+ binding site [ion binding]; other site
459424005968	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
459424005969	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005970	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005971	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005972	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424005973	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424005974	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424005975	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424005976	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
459424005977	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424005978	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
459424005979	putative hydrophobic ligand binding site [chemical binding]; other site
459424005980	protein interface [polypeptide binding]; other site
459424005981	gate; other site
459424005982	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424005983	Beta-lactamase; Region: Beta-lactamase; pfam00144
459424005984	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424005985	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
459424005986	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424005987	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424005988	Predicted ATPase [General function prediction only]; Region: COG3903
459424005989	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
459424005990	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
459424005991	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424005992	acyl-activating enzyme (AAE) consensus motif; other site
459424005993	active site
459424005994	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
459424005995	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424005996	Coenzyme A binding pocket [chemical binding]; other site
459424005997	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
459424005998	Phosphotransferase enzyme family; Region: APH; pfam01636
459424005999	putative active site [active]
459424006000	putative substrate binding site [chemical binding]; other site
459424006001	ATP binding site [chemical binding]; other site
459424006002	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006003	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006004	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006005	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006006	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
459424006007	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
459424006008	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
459424006009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
459424006010	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
459424006011	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
459424006012	active site
459424006013	putative substrate binding pocket [chemical binding]; other site
459424006014	peroxiredoxin; Provisional; Region: PRK13189
459424006015	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
459424006016	dimer interface [polypeptide binding]; other site
459424006017	decamer (pentamer of dimers) interface [polypeptide binding]; other site
459424006018	catalytic triad [active]
459424006019	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
459424006020	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
459424006021	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
459424006022	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
459424006023	short chain dehydrogenase; Provisional; Region: PRK05867
459424006024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424006025	NAD(P) binding site [chemical binding]; other site
459424006026	active site
459424006027	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424006028	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424006029	RibD C-terminal domain; Region: RibD_C; cl17279
459424006030	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
459424006031	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
459424006032	conserved cys residue [active]
459424006033	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
459424006034	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
459424006035	conserved cys residue [active]
459424006036	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
459424006037	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
459424006038	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
459424006039	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
459424006040	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
459424006041	FeS/SAM binding site; other site
459424006042	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
459424006043	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
459424006044	dimer interface [polypeptide binding]; other site
459424006045	catalytic triad [active]
459424006046	peroxidatic and resolving cysteines [active]
459424006047	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424006048	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424006049	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424006050	Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441
459424006051	active site
459424006052	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
459424006053	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424006054	FAD binding site [chemical binding]; other site
459424006055	substrate binding site [chemical binding]; other site
459424006056	catalytic base [active]
459424006057	enoyl-CoA hydratase; Provisional; Region: PRK08290
459424006058	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424006059	substrate binding site [chemical binding]; other site
459424006060	oxyanion hole (OAH) forming residues; other site
459424006061	trimer interface [polypeptide binding]; other site
459424006062	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424006063	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
459424006064	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
459424006065	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424006066	catalytic loop [active]
459424006067	iron binding site [ion binding]; other site
459424006068	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
459424006069	FAD binding pocket [chemical binding]; other site
459424006070	FAD binding motif [chemical binding]; other site
459424006071	phosphate binding motif [ion binding]; other site
459424006072	beta-alpha-beta structure motif; other site
459424006073	NAD binding pocket [chemical binding]; other site
459424006074	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
459424006075	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
459424006076	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
459424006077	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
459424006078	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
459424006079	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424006080	putative Zn2+ binding site [ion binding]; other site
459424006081	putative DNA binding site [nucleotide binding]; other site
459424006082	dimerization interface [polypeptide binding]; other site
459424006083	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006084	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
459424006085	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424006086	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424006087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424006088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424006089	SCP-2 sterol transfer family; Region: SCP2; cl01225
459424006090	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
459424006091	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
459424006092	NAD(P) binding site [chemical binding]; other site
459424006093	catalytic residues [active]
459424006094	GAF domain; Region: GAF; cl17456
459424006095	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
459424006096	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
459424006097	DNA binding residues [nucleotide binding]
459424006098	dimerization interface [polypeptide binding]; other site
459424006099	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424006100	Cytochrome P450; Region: p450; cl12078
459424006101	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424006102	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
459424006103	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
459424006104	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
459424006105	Permease; Region: Permease; pfam02405
459424006106	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
459424006107	Permease; Region: Permease; pfam02405
459424006108	mce related protein; Region: MCE; pfam02470
459424006109	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424006110	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424006111	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424006112	mce related protein; Region: MCE; pfam02470
459424006113	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424006114	Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123
459424006115	dimer interface [polypeptide binding]; other site
459424006116	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424006117	mce related protein; Region: MCE; pfam02470
459424006118	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
459424006119	mce related protein; Region: MCE; pfam02470
459424006120	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
459424006121	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424006122	mce related protein; Region: MCE; pfam02470
459424006123	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424006124	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424006125	mce related protein; Region: MCE; pfam02470
459424006126	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
459424006127	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424006128	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006129	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006130	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424006131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424006132	NAD(P) binding site [chemical binding]; other site
459424006133	active site
459424006134	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
459424006135	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
459424006136	active site
459424006137	catalytic residues [active]
459424006138	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424006139	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
459424006140	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006141	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006142	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006143	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006144	Peptidase family M48; Region: Peptidase_M48; pfam01435
459424006145	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
459424006146	Cutinase; Region: Cutinase; pfam01083
459424006147	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006148	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006149	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
459424006150	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
459424006151	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424006152	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
459424006153	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
459424006154	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
459424006155	Phosphoglycerate kinase; Region: PGK; pfam00162
459424006156	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
459424006157	substrate binding site [chemical binding]; other site
459424006158	hinge regions; other site
459424006159	ADP binding site [chemical binding]; other site
459424006160	catalytic site [active]
459424006161	triosephosphate isomerase; Provisional; Region: PRK14567
459424006162	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
459424006163	substrate binding site [chemical binding]; other site
459424006164	dimer interface [polypeptide binding]; other site
459424006165	catalytic triad [active]
459424006166	hypothetical protein; Provisional; Region: PRK06149
459424006167	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
459424006168	active site
459424006169	ATP binding site [chemical binding]; other site
459424006170	substrate binding site [chemical binding]; other site
459424006171	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424006172	inhibitor-cofactor binding pocket; inhibition site
459424006173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424006174	catalytic residue [active]
459424006175	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
459424006176	Transcriptional regulators [Transcription]; Region: GntR; COG1802
459424006177	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424006178	DNA-binding site [nucleotide binding]; DNA binding site
459424006179	FCD domain; Region: FCD; pfam07729
459424006180	Ciliary basal body-associated, B9 protein; Region: B9-C2; pfam07162
459424006181	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
459424006182	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
459424006183	PE family; Region: PE; pfam00934
459424006184	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
459424006185	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
459424006186	putative active site [active]
459424006187	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
459424006188	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
459424006189	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
459424006190	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
459424006191	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
459424006192	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
459424006193	putative active site [active]
459424006194	transaldolase; Provisional; Region: PRK03903
459424006195	catalytic residue [active]
459424006196	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
459424006197	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
459424006198	TPP-binding site [chemical binding]; other site
459424006199	dimer interface [polypeptide binding]; other site
459424006200	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
459424006201	PYR/PP interface [polypeptide binding]; other site
459424006202	dimer interface [polypeptide binding]; other site
459424006203	TPP binding site [chemical binding]; other site
459424006204	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
459424006205	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
459424006206	UbiA prenyltransferase family; Region: UbiA; pfam01040
459424006207	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006208	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006209	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006210	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006211	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006212	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006213	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
459424006214	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
459424006215	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
459424006216	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424006217	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006218	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006219	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006220	Protein of unknown function (DUF503); Region: DUF503; cl00669
459424006221	proteasome ATPase; Region: pup_AAA; TIGR03689
459424006222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424006223	Walker A motif; other site
459424006224	ATP binding site [chemical binding]; other site
459424006225	Walker B motif; other site
459424006226	arginine finger; other site
459424006227	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
459424006228	Pup-like protein; Region: Pup; cl05289
459424006229	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
459424006230	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
459424006231	active site
459424006232	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
459424006233	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
459424006234	active site
459424006235	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
459424006236	Predicted transcriptional regulator [Transcription]; Region: COG2378
459424006237	WYL domain; Region: WYL; pfam13280
459424006238	Predicted transcriptional regulator [Transcription]; Region: COG2378
459424006239	WYL domain; Region: WYL; pfam13280
459424006240	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
459424006241	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
459424006242	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
459424006243	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
459424006244	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
459424006245	ATP binding site [chemical binding]; other site
459424006246	putative Mg++ binding site [ion binding]; other site
459424006247	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
459424006248	nucleotide binding region [chemical binding]; other site
459424006249	ATP-binding site [chemical binding]; other site
459424006250	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
459424006251	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
459424006252	5'-3' exonuclease; Region: 53EXOc; smart00475
459424006253	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
459424006254	active site
459424006255	metal binding site 1 [ion binding]; metal-binding site
459424006256	putative 5' ssDNA interaction site; other site
459424006257	metal binding site 3; metal-binding site
459424006258	metal binding site 2 [ion binding]; metal-binding site
459424006259	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
459424006260	putative DNA binding site [nucleotide binding]; other site
459424006261	putative metal binding site [ion binding]; other site
459424006262	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
459424006263	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
459424006264	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
459424006265	active site
459424006266	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424006267	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424006268	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006269	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006270	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006271	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006272	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006273	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006274	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
459424006275	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
459424006276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
459424006277	P-loop containing region of AAA domain; Region: AAA_29; cl17516
459424006278	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
459424006279	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
459424006280	active site
459424006281	catalytic site [active]
459424006282	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
459424006283	ligand binding surface [chemical binding]; other site
459424006284	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
459424006285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424006286	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
459424006287	NAD(P) binding site [chemical binding]; other site
459424006288	active site
459424006289	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
459424006290	active site
459424006291	putative homodimer interface [polypeptide binding]; other site
459424006292	SAM binding site [chemical binding]; other site
459424006293	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
459424006294	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
459424006295	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
459424006296	active site
459424006297	SAM binding site [chemical binding]; other site
459424006298	homodimer interface [polypeptide binding]; other site
459424006299	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
459424006300	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
459424006301	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
459424006302	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424006303	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
459424006304	DNA binding residues [nucleotide binding]
459424006305	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424006306	Methyltransferase domain; Region: Methyltransf_31; pfam13847
459424006307	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424006308	S-adenosylmethionine binding site [chemical binding]; other site
459424006309	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
459424006310	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
459424006311	active site
459424006312	SAM binding site [chemical binding]; other site
459424006313	homodimer interface [polypeptide binding]; other site
459424006314	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
459424006315	active site
459424006316	SAM binding site [chemical binding]; other site
459424006317	homodimer interface [polypeptide binding]; other site
459424006318	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
459424006319	Precorrin-8X methylmutase; Region: CbiC; pfam02570
459424006320	precorrin-3B synthase; Region: CobG; TIGR02435
459424006321	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
459424006322	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
459424006323	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424006324	cyclase homology domain; Region: CHD; cd07302
459424006325	nucleotidyl binding site; other site
459424006326	metal binding site [ion binding]; metal-binding site
459424006327	dimer interface [polypeptide binding]; other site
459424006328	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
459424006329	short chain dehydrogenase; Provisional; Region: PRK07825
459424006330	classical (c) SDRs; Region: SDR_c; cd05233
459424006331	NAD(P) binding site [chemical binding]; other site
459424006332	active site
459424006333	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
459424006334	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
459424006335	Moco binding site; other site
459424006336	metal coordination site [ion binding]; other site
459424006337	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
459424006338	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
459424006339	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
459424006340	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
459424006341	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
459424006342	conserved cys residue [active]
459424006343	Uncharacterized conserved protein [Function unknown]; Region: COG2966
459424006344	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
459424006345	Uncharacterized conserved protein [Function unknown]; Region: COG3610
459424006346	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006347	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006348	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006349	Dienelactone hydrolase family; Region: DLH; pfam01738
459424006350	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
459424006351	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
459424006352	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
459424006353	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424006354	active site
459424006355	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
459424006356	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
459424006357	putative active site [active]
459424006358	catalytic triad [active]
459424006359	putative dimer interface [polypeptide binding]; other site
459424006360	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
459424006361	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
459424006362	Ligand binding site; other site
459424006363	Putative Catalytic site; other site
459424006364	DXD motif; other site
459424006365	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006366	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006367	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006368	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
459424006369	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424006370	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424006371	active site
459424006372	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424006373	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424006374	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424006375	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424006376	Enoylreductase; Region: PKS_ER; smart00829
459424006377	NAD(P) binding site [chemical binding]; other site
459424006378	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424006379	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424006380	putative NADP binding site [chemical binding]; other site
459424006381	active site
459424006382	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424006383	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424006384	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424006385	active site
459424006386	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424006387	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424006388	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424006389	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424006390	Enoylreductase; Region: PKS_ER; smart00829
459424006391	NAD(P) binding site [chemical binding]; other site
459424006392	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424006393	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424006394	putative NADP binding site [chemical binding]; other site
459424006395	active site
459424006396	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424006397	hypothetical protein; Provisional; Region: PRK05865
459424006398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424006399	NAD(P) binding site [chemical binding]; other site
459424006400	active site
459424006401	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
459424006402	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
459424006403	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
459424006404	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
459424006405	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424006406	substrate binding pocket [chemical binding]; other site
459424006407	catalytic triad [active]
459424006408	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006409	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006410	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006411	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
459424006412	AAA domain; Region: AAA_33; pfam13671
459424006413	ATP-binding site [chemical binding]; other site
459424006414	Gluconate-6-phosphate binding site [chemical binding]; other site
459424006415	Predicted membrane protein [Function unknown]; Region: COG2259
459424006416	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
459424006417	Isochorismatase family; Region: Isochorismatase; pfam00857
459424006418	catalytic triad [active]
459424006419	metal binding site [ion binding]; metal-binding site
459424006420	conserved cis-peptide bond; other site
459424006421	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
459424006422	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
459424006423	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
459424006424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424006425	dimer interface [polypeptide binding]; other site
459424006426	conserved gate region; other site
459424006427	putative PBP binding loops; other site
459424006428	ABC-ATPase subunit interface; other site
459424006429	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
459424006430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424006431	dimer interface [polypeptide binding]; other site
459424006432	conserved gate region; other site
459424006433	putative PBP binding loops; other site
459424006434	ABC-ATPase subunit interface; other site
459424006435	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
459424006436	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
459424006437	Walker A/P-loop; other site
459424006438	ATP binding site [chemical binding]; other site
459424006439	Q-loop/lid; other site
459424006440	ABC transporter signature motif; other site
459424006441	Walker B; other site
459424006442	D-loop; other site
459424006443	H-loop/switch region; other site
459424006444	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
459424006445	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
459424006446	nucleophile elbow; other site
459424006447	PE family; Region: PE; pfam00934
459424006448	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
459424006449	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424006450	PPE family; Region: PPE; pfam00823
459424006451	PE family; Region: PE; pfam00934
459424006452	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424006453	PPE family; Region: PPE; pfam00823
459424006454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
459424006455	OsmC-like protein; Region: OsmC; pfam02566
459424006456	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
459424006457	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424006458	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424006459	DNA binding residues [nucleotide binding]
459424006460	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424006461	Ligand Binding Site [chemical binding]; other site
459424006462	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424006463	Ligand Binding Site [chemical binding]; other site
459424006464	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424006465	Ligand Binding Site [chemical binding]; other site
459424006466	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424006467	Ligand Binding Site [chemical binding]; other site
459424006468	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
459424006469	active site
459424006470	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
459424006471	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
459424006472	putative dimer interface [polypeptide binding]; other site
459424006473	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
459424006474	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
459424006475	DNA binding residues [nucleotide binding]
459424006476	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
459424006477	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
459424006478	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424006479	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
459424006480	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424006481	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424006482	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424006483	Ligand Binding Site [chemical binding]; other site
459424006484	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424006485	Ligand Binding Site [chemical binding]; other site
459424006486	Acyltransferase family; Region: Acyl_transf_3; pfam01757
459424006487	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
459424006488	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
459424006489	homotetramer interface [polypeptide binding]; other site
459424006490	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424006491	NAD binding site [chemical binding]; other site
459424006492	homodimer interface [polypeptide binding]; other site
459424006493	active site
459424006494	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
459424006495	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424006496	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424006497	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424006498	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424006499	Cytochrome P450; Region: p450; cl12078
459424006500	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
459424006501	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424006502	active site 2 [active]
459424006503	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006504	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006505	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006506	Predicted membrane protein [Function unknown]; Region: COG4325
459424006507	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
459424006508	enoyl-CoA hydratase; Provisional; Region: PRK08260
459424006509	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424006510	substrate binding site [chemical binding]; other site
459424006511	oxyanion hole (OAH) forming residues; other site
459424006512	trimer interface [polypeptide binding]; other site
459424006513	PE family; Region: PE; pfam00934
459424006514	Cupin; Region: Cupin_1; smart00835
459424006515	Cupin; Region: Cupin_1; smart00835
459424006516	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424006517	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
459424006518	Hemerythrin-like domain; Region: Hr-like; cd12108
459424006519	Fe binding site [ion binding]; other site
459424006520	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
459424006521	putative catalytic residues [active]
459424006522	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424006523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424006524	putative substrate translocation pore; other site
459424006525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424006526	putative substrate translocation pore; other site
459424006527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424006528	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424006529	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424006530	ligand binding site [chemical binding]; other site
459424006531	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
459424006532	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
459424006533	nucleophile elbow; other site
459424006534	hypothetical protein; Provisional; Region: PRK02237
459424006535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424006536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424006537	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
459424006538	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
459424006539	NAD(P) binding site [chemical binding]; other site
459424006540	PemK-like protein; Region: PemK; pfam02452
459424006541	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
459424006542	active site
459424006543	Cellulose binding domain; Region: CBM_2; pfam00553
459424006544	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
459424006545	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
459424006546	putative NAD(P) binding site [chemical binding]; other site
459424006547	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006548	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
459424006549	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
459424006550	oligomer interface [polypeptide binding]; other site
459424006551	D-cysteine desulfhydrase; Validated; Region: PRK03910
459424006552	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
459424006553	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424006554	catalytic residue [active]
459424006555	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424006556	PPE family; Region: PPE; pfam00823
459424006557	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424006558	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424006559	ligand binding site [chemical binding]; other site
459424006560	flexible hinge region; other site
459424006561	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
459424006562	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424006563	active site
459424006564	ATP binding site [chemical binding]; other site
459424006565	substrate binding site [chemical binding]; other site
459424006566	activation loop (A-loop); other site
459424006567	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
459424006568	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424006569	MarR family; Region: MarR; pfam01047
459424006570	Nitroreductase family; Region: Nitroreductase; pfam00881
459424006571	FMN binding site [chemical binding]; other site
459424006572	dimer interface [polypeptide binding]; other site
459424006573	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
459424006574	putative catalytic residue [active]
459424006575	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
459424006576	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424006577	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424006578	acyl-activating enzyme (AAE) consensus motif; other site
459424006579	acyl-activating enzyme (AAE) consensus motif; other site
459424006580	AMP binding site [chemical binding]; other site
459424006581	active site
459424006582	CoA binding site [chemical binding]; other site
459424006583	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424006584	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
459424006585	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
459424006586	putative NAD(P) binding site [chemical binding]; other site
459424006587	active site
459424006588	putative substrate binding site [chemical binding]; other site
459424006589	YcaO-like family; Region: YcaO; pfam02624
459424006590	Cutinase; Region: Cutinase; pfam01083
459424006591	PE family; Region: PE; pfam00934
459424006592	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
459424006593	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
459424006594	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424006595	Cytochrome P450; Region: p450; cl12078
459424006596	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006597	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006598	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006599	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424006600	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424006601	PPE family; Region: PPE; pfam00823
459424006602	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424006603	Short C-terminal domain; Region: SHOCT; pfam09851
459424006604	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
459424006605	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424006606	active site
459424006607	metal binding site [ion binding]; metal-binding site
459424006608	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
459424006609	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424006610	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
459424006611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424006612	S-adenosylmethionine binding site [chemical binding]; other site
459424006613	Protein of unknown function, DUF608; Region: DUF608; pfam04685
459424006614	Methyltransferase domain; Region: Methyltransf_24; pfam13578
459424006615	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424006616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424006617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424006618	S-adenosylmethionine binding site [chemical binding]; other site
459424006619	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
459424006620	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
459424006621	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
459424006622	active site residue [active]
459424006623	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
459424006624	active site residue [active]
459424006625	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
459424006626	Domain of unknown function (DUF385); Region: DUF385; cl04387
459424006627	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
459424006628	metal binding site 2 [ion binding]; metal-binding site
459424006629	putative DNA binding helix; other site
459424006630	metal binding site 1 [ion binding]; metal-binding site
459424006631	dimer interface [polypeptide binding]; other site
459424006632	structural Zn2+ binding site [ion binding]; other site
459424006633	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
459424006634	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
459424006635	heme binding site [chemical binding]; other site
459424006636	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
459424006637	BCCT family transporter; Region: BCCT; pfam02028
459424006638	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006639	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006640	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006641	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424006642	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
459424006643	nucleophilic elbow; other site
459424006644	catalytic triad; other site
459424006645	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
459424006646	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424006647	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424006648	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424006649	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424006650	PE family; Region: PE; pfam00934
459424006651	PE-PPE domain; Region: PE-PPE; pfam08237
459424006652	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424006653	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
459424006654	putative acyl-acceptor binding pocket; other site
459424006655	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424006656	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424006657	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424006658	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424006659	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424006660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
459424006661	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
459424006662	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
459424006663	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
459424006664	phosphate binding site [ion binding]; other site
459424006665	putative substrate binding pocket [chemical binding]; other site
459424006666	dimer interface [polypeptide binding]; other site
459424006667	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
459424006668	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
459424006669	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
459424006670	GIY-YIG motif/motif A; other site
459424006671	active site
459424006672	catalytic site [active]
459424006673	putative DNA binding site [nucleotide binding]; other site
459424006674	metal binding site [ion binding]; metal-binding site
459424006675	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
459424006676	Helix-hairpin-helix motif; Region: HHH; pfam00633
459424006677	helix-hairpin-helix signature motif; other site
459424006678	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424006679	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424006680	active site
459424006681	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424006682	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
459424006683	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
459424006684	homopentamer interface [polypeptide binding]; other site
459424006685	active site
459424006686	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
459424006687	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
459424006688	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
459424006689	dimerization interface [polypeptide binding]; other site
459424006690	active site
459424006691	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
459424006692	Lumazine binding domain; Region: Lum_binding; pfam00677
459424006693	Lumazine binding domain; Region: Lum_binding; pfam00677
459424006694	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
459424006695	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424006696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424006697	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
459424006698	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
459424006699	catalytic motif [active]
459424006700	Zn binding site [ion binding]; other site
459424006701	RibD C-terminal domain; Region: RibD_C; pfam01872
459424006702	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
459424006703	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
459424006704	substrate binding site [chemical binding]; other site
459424006705	hexamer interface [polypeptide binding]; other site
459424006706	metal binding site [ion binding]; metal-binding site
459424006707	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
459424006708	putative RNA binding site [nucleotide binding]; other site
459424006709	16S rRNA methyltransferase B; Provisional; Region: PRK14902
459424006710	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
459424006711	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
459424006712	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
459424006713	putative active site [active]
459424006714	substrate binding site [chemical binding]; other site
459424006715	putative cosubstrate binding site; other site
459424006716	catalytic site [active]
459424006717	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
459424006718	substrate binding site [chemical binding]; other site
459424006719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424006720	S-adenosylmethionine binding site [chemical binding]; other site
459424006721	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424006722	MarR family; Region: MarR; pfam01047
459424006723	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
459424006724	Methyltransferase domain; Region: Methyltransf_11; pfam08241
459424006725	primosome assembly protein PriA; Provisional; Region: PRK14873
459424006726	Predicted membrane protein [Function unknown]; Region: COG3714
459424006727	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424006728	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424006729	substrate binding pocket [chemical binding]; other site
459424006730	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424006731	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424006732	substrate binding pocket [chemical binding]; other site
459424006733	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424006734	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424006735	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
459424006736	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
459424006737	S-adenosylmethionine synthetase; Validated; Region: PRK05250
459424006738	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
459424006739	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
459424006740	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
459424006741	Flavoprotein; Region: Flavoprotein; pfam02441
459424006742	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
459424006743	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
459424006744	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
459424006745	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
459424006746	catalytic site [active]
459424006747	G-X2-G-X-G-K; other site
459424006748	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
459424006749	active site
459424006750	dimer interface [polypeptide binding]; other site
459424006751	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
459424006752	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
459424006753	ATP-grasp domain; Region: ATP-grasp_4; cl17255
459424006754	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
459424006755	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
459424006756	ATP-grasp domain; Region: ATP-grasp_4; cl17255
459424006757	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
459424006758	IMP binding site; other site
459424006759	dimer interface [polypeptide binding]; other site
459424006760	interdomain contacts; other site
459424006761	partial ornithine binding site; other site
459424006762	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
459424006763	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
459424006764	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
459424006765	catalytic site [active]
459424006766	subunit interface [polypeptide binding]; other site
459424006767	dihydroorotase; Validated; Region: pyrC; PRK09357
459424006768	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424006769	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
459424006770	active site
459424006771	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
459424006772	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
459424006773	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
459424006774	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
459424006775	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
459424006776	active site
459424006777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424006778	S-adenosylmethionine binding site [chemical binding]; other site
459424006779	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
459424006780	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
459424006781	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
459424006782	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
459424006783	malonyl-CoA binding site [chemical binding]; other site
459424006784	dimer interface [polypeptide binding]; other site
459424006785	active site
459424006786	product binding site; other site
459424006787	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173
459424006788	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
459424006789	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
459424006790	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424006791	Beta-lactamase; Region: Beta-lactamase; pfam00144
459424006792	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
459424006793	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
459424006794	hypothetical protein; Provisional; Region: PRK07236
459424006795	hypothetical protein; Provisional; Region: PRK07588
459424006796	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
459424006797	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
459424006798	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424006799	catalytic residue [active]
459424006800	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
459424006801	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
459424006802	putative RNA binding site [nucleotide binding]; other site
459424006803	elongation factor P; Validated; Region: PRK00529
459424006804	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
459424006805	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
459424006806	RNA binding site [nucleotide binding]; other site
459424006807	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
459424006808	RNA binding site [nucleotide binding]; other site
459424006809	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
459424006810	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
459424006811	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
459424006812	active site
459424006813	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
459424006814	Dehydroquinase class II; Region: DHquinase_II; pfam01220
459424006815	trimer interface [polypeptide binding]; other site
459424006816	active site
459424006817	dimer interface [polypeptide binding]; other site
459424006818	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
459424006819	active site
459424006820	dimer interface [polypeptide binding]; other site
459424006821	metal binding site [ion binding]; metal-binding site
459424006822	shikimate kinase; Reviewed; Region: aroK; PRK00131
459424006823	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
459424006824	ADP binding site [chemical binding]; other site
459424006825	magnesium binding site [ion binding]; other site
459424006826	putative shikimate binding site; other site
459424006827	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
459424006828	chorismate synthase; Validated; Region: PRK05382
459424006829	Tetramer interface [polypeptide binding]; other site
459424006830	active site
459424006831	FMN-binding site [chemical binding]; other site
459424006832	shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809
459424006833	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
459424006834	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
459424006835	shikimate binding site; other site
459424006836	NAD(P) binding site [chemical binding]; other site
459424006837	YceG-like family; Region: YceG; pfam02618
459424006838	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
459424006839	dimerization interface [polypeptide binding]; other site
459424006840	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
459424006841	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
459424006842	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
459424006843	motif 1; other site
459424006844	active site
459424006845	motif 2; other site
459424006846	motif 3; other site
459424006847	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
459424006848	DHHA1 domain; Region: DHHA1; pfam02272
459424006849	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
459424006850	recombination factor protein RarA; Reviewed; Region: PRK13342
459424006851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424006852	Walker A motif; other site
459424006853	ATP binding site [chemical binding]; other site
459424006854	Walker B motif; other site
459424006855	arginine finger; other site
459424006856	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
459424006857	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
459424006858	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
459424006859	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
459424006860	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
459424006861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
459424006862	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
459424006863	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
459424006864	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
459424006865	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
459424006866	Protein of unknown function (DUF419); Region: DUF419; cl15265
459424006867	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
459424006868	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
459424006869	dimer interface [polypeptide binding]; other site
459424006870	anticodon binding site; other site
459424006871	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
459424006872	homodimer interface [polypeptide binding]; other site
459424006873	motif 1; other site
459424006874	active site
459424006875	motif 2; other site
459424006876	GAD domain; Region: GAD; pfam02938
459424006877	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
459424006878	active site
459424006879	motif 3; other site
459424006880	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
459424006881	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
459424006882	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
459424006883	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
459424006884	putative hydrophobic ligand binding site [chemical binding]; other site
459424006885	protein interface [polypeptide binding]; other site
459424006886	gate; other site
459424006887	Predicted metalloprotease [General function prediction only]; Region: COG2321
459424006888	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
459424006889	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
459424006890	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
459424006891	inhibitor site; inhibition site
459424006892	active site
459424006893	dimer interface [polypeptide binding]; other site
459424006894	catalytic residue [active]
459424006895	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
459424006896	intersubunit interface [polypeptide binding]; other site
459424006897	active site
459424006898	Zn2+ binding site [ion binding]; other site
459424006899	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
459424006900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
459424006901	non-specific DNA binding site [nucleotide binding]; other site
459424006902	salt bridge; other site
459424006903	sequence-specific DNA binding site [nucleotide binding]; other site
459424006904	Cupin domain; Region: Cupin_2; pfam07883
459424006905	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
459424006906	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
459424006907	active site
459424006908	nucleophile elbow; other site
459424006909	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
459424006910	active site
459424006911	metal binding site [ion binding]; metal-binding site
459424006912	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
459424006913	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
459424006914	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424006915	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424006916	active site
459424006917	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
459424006918	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
459424006919	dimer interface [polypeptide binding]; other site
459424006920	motif 1; other site
459424006921	active site
459424006922	motif 2; other site
459424006923	motif 3; other site
459424006924	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
459424006925	anticodon binding site; other site
459424006926	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
459424006927	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
459424006928	active site
459424006929	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
459424006930	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
459424006931	Zn2+ binding site [ion binding]; other site
459424006932	Mg2+ binding site [ion binding]; other site
459424006933	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
459424006934	synthetase active site [active]
459424006935	NTP binding site [chemical binding]; other site
459424006936	metal binding site [ion binding]; metal-binding site
459424006937	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
459424006938	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
459424006939	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
459424006940	active site
459424006941	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
459424006942	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
459424006943	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
459424006944	Protein export membrane protein; Region: SecD_SecF; pfam02355
459424006945	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
459424006946	Protein export membrane protein; Region: SecD_SecF; cl14618
459424006947	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
459424006948	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
459424006949	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424006950	inhibitor-cofactor binding pocket; inhibition site
459424006951	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424006952	catalytic residue [active]
459424006953	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
459424006954	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424006955	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424006956	acyl-activating enzyme (AAE) consensus motif; other site
459424006957	acyl-activating enzyme (AAE) consensus motif; other site
459424006958	AMP binding site [chemical binding]; other site
459424006959	active site
459424006960	CoA binding site [chemical binding]; other site
459424006961	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424006962	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
459424006963	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
459424006964	putative NAD(P) binding site [chemical binding]; other site
459424006965	active site
459424006966	putative substrate binding site [chemical binding]; other site
459424006967	PE family; Region: PE; pfam00934
459424006968	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
459424006969	PE family; Region: PE; pfam00934
459424006970	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
459424006971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424006972	Walker A motif; other site
459424006973	ATP binding site [chemical binding]; other site
459424006974	Walker B motif; other site
459424006975	arginine finger; other site
459424006976	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
459424006977	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
459424006978	RuvA N terminal domain; Region: RuvA_N; pfam01330
459424006979	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
459424006980	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
459424006981	active site
459424006982	putative DNA-binding cleft [nucleotide binding]; other site
459424006983	dimer interface [polypeptide binding]; other site
459424006984	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
459424006985	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
459424006986	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
459424006987	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
459424006988	spermidine synthase; Provisional; Region: PRK03612
459424006989	Spermine/spermidine synthase; Region: Spermine_synth; pfam01564
459424006990	PE family; Region: PE; pfam00934
459424006991	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
459424006992	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424006993	hypothetical protein; Validated; Region: PRK00110
459424006994	PE family; Region: PE; pfam00934
459424006995	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
459424006996	predicted active site [active]
459424006997	catalytic triad [active]
459424006998	acyl-CoA thioesterase II; Region: tesB; TIGR00189
459424006999	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
459424007000	active site
459424007001	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
459424007002	catalytic triad [active]
459424007003	dimer interface [polypeptide binding]; other site
459424007004	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
459424007005	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
459424007006	active site
459424007007	multimer interface [polypeptide binding]; other site
459424007008	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
459424007009	nudix motif; other site
459424007010	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424007011	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
459424007012	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
459424007013	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
459424007014	putative acyl-acceptor binding pocket; other site
459424007015	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
459424007016	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
459424007017	nucleotide binding site/active site [active]
459424007018	HIT family signature motif; other site
459424007019	catalytic residue [active]
459424007020	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
459424007021	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
459424007022	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
459424007023	active site
459424007024	dimer interface [polypeptide binding]; other site
459424007025	motif 1; other site
459424007026	motif 2; other site
459424007027	motif 3; other site
459424007028	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
459424007029	anticodon binding site; other site
459424007030	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
459424007031	CoenzymeA binding site [chemical binding]; other site
459424007032	subunit interaction site [polypeptide binding]; other site
459424007033	PHB binding site; other site
459424007034	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
459424007035	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
459424007036	active site
459424007037	catalytic tetrad [active]
459424007038	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
459424007039	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
459424007040	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
459424007041	Predicted transcriptional regulator [Transcription]; Region: COG2345
459424007042	putative DNA binding site [nucleotide binding]; other site
459424007043	putative Zn2+ binding site [ion binding]; other site
459424007044	Ferredoxin [Energy production and conversion]; Region: COG1146
459424007045	4Fe-4S binding domain; Region: Fer4; pfam00037
459424007046	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
459424007047	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
459424007048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424007049	S-adenosylmethionine binding site [chemical binding]; other site
459424007050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424007051	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424007052	Ligand Binding Site [chemical binding]; other site
459424007053	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424007054	Ligand Binding Site [chemical binding]; other site
459424007055	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424007056	Ligand Binding Site [chemical binding]; other site
459424007057	Universal stress protein family; Region: Usp; pfam00582
459424007058	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
459424007059	active site
459424007060	Peptidase family M50; Region: Peptidase_M50; pfam02163
459424007061	putative substrate binding region [chemical binding]; other site
459424007062	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
459424007063	FOG: CBS domain [General function prediction only]; Region: COG0517
459424007064	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424007065	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424007066	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
459424007067	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
459424007068	acyl-activating enzyme (AAE) consensus motif; other site
459424007069	putative AMP binding site [chemical binding]; other site
459424007070	putative active site [active]
459424007071	putative CoA binding site [chemical binding]; other site
459424007072	Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503
459424007073	peptide chain release factor 1; Provisional; Region: PRK04011
459424007074	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926
459424007075	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
459424007076	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
459424007077	PE family; Region: PE; pfam00934
459424007078	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007079	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007080	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007081	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007082	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007083	MbtH-like protein; Region: MbtH; pfam03621
459424007084	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
459424007085	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
459424007086	acyl-activating enzyme (AAE) consensus motif; other site
459424007087	AMP binding site [chemical binding]; other site
459424007088	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424007089	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424007090	PPE family; Region: PPE; pfam00823
459424007091	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424007092	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424007093	PPE family; Region: PPE; pfam00823
459424007094	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424007095	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424007096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424007097	putative substrate translocation pore; other site
459424007098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424007099	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007100	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007101	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007102	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
459424007103	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
459424007104	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
459424007105	TatD related DNase; Region: TatD_DNase; pfam01026
459424007106	active site
459424007107	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
459424007108	Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945
459424007109	UbiA prenyltransferase family; Region: UbiA; pfam01040
459424007110	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
459424007111	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
459424007112	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
459424007113	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424007114	S-adenosylmethionine binding site [chemical binding]; other site
459424007115	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
459424007116	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
459424007117	active site
459424007118	DNA binding site [nucleotide binding]
459424007119	Int/Topo IB signature motif; other site
459424007120	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
459424007121	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
459424007122	dimer interface [polypeptide binding]; other site
459424007123	ADP-ribose binding site [chemical binding]; other site
459424007124	active site
459424007125	nudix motif; other site
459424007126	metal binding site [ion binding]; metal-binding site
459424007127	CTP synthetase; Validated; Region: pyrG; PRK05380
459424007128	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
459424007129	Catalytic site [active]
459424007130	active site
459424007131	UTP binding site [chemical binding]; other site
459424007132	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
459424007133	active site
459424007134	putative oxyanion hole; other site
459424007135	catalytic triad [active]
459424007136	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
459424007137	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
459424007138	Thiamine pyrophosphokinase; Region: TPK; cl08415
459424007139	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
459424007140	DNA repair protein RecN; Region: recN; TIGR00634
459424007141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424007142	Walker A/P-loop; other site
459424007143	ATP binding site [chemical binding]; other site
459424007144	Q-loop/lid; other site
459424007145	ABC transporter signature motif; other site
459424007146	Walker B; other site
459424007147	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
459424007148	ABC transporter signature motif; other site
459424007149	Walker B; other site
459424007150	D-loop; other site
459424007151	H-loop/switch region; other site
459424007152	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
459424007153	ATP-NAD kinase; Region: NAD_kinase; pfam01513
459424007154	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
459424007155	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
459424007156	RNA binding surface [nucleotide binding]; other site
459424007157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424007158	S-adenosylmethionine binding site [chemical binding]; other site
459424007159	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
459424007160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424007161	active site
459424007162	motif I; other site
459424007163	motif II; other site
459424007164	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
459424007165	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
459424007166	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424007167	uncharacterized domain; Region: TIGR00702
459424007168	YcaO-like family; Region: YcaO; pfam02624
459424007169	Uncharacterized conserved protein [Function unknown]; Region: COG3482
459424007170	PE family; Region: PE; pfam00934
459424007171	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
459424007172	Double zinc ribbon; Region: DZR; pfam12773
459424007173	PE family; Region: PE; pfam00934
459424007174	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007175	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007176	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007177	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
459424007178	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
459424007179	active site
459424007180	HIGH motif; other site
459424007181	dimer interface [polypeptide binding]; other site
459424007182	KMSKS motif; other site
459424007183	S4 RNA-binding domain; Region: S4; smart00363
459424007184	RNA binding surface [nucleotide binding]; other site
459424007185	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
459424007186	active site
459424007187	DNA binding site [nucleotide binding]
459424007188	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
459424007189	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
459424007190	Walker A/P-loop; other site
459424007191	ATP binding site [chemical binding]; other site
459424007192	Q-loop/lid; other site
459424007193	ABC transporter signature motif; other site
459424007194	Walker B; other site
459424007195	D-loop; other site
459424007196	H-loop/switch region; other site
459424007197	PE family; Region: PE; pfam00934
459424007198	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
459424007199	putative dimer interface [polypeptide binding]; other site
459424007200	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424007201	Trm112p-like protein; Region: Trm112p; cl01066
459424007202	acyl-CoA synthetase; Validated; Region: PRK07868
459424007203	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424007204	acyl-activating enzyme (AAE) consensus motif; other site
459424007205	AMP binding site [chemical binding]; other site
459424007206	active site
459424007207	CoA binding site [chemical binding]; other site
459424007208	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
459424007209	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
459424007210	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
459424007211	ABC transporter; Region: ABC_tran_2; pfam12848
459424007212	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
459424007213	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424007214	Cytochrome P450; Region: p450; cl12078
459424007215	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
459424007216	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
459424007217	malonyl-CoA binding site [chemical binding]; other site
459424007218	dimer interface [polypeptide binding]; other site
459424007219	active site
459424007220	product binding site; other site
459424007221	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424007222	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424007223	active site
459424007224	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424007225	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424007226	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424007227	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424007228	active site
459424007229	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424007230	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424007231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424007232	Enoylreductase; Region: PKS_ER; smart00829
459424007233	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424007234	NAD(P) binding site [chemical binding]; other site
459424007235	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424007236	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424007237	putative NADP binding site [chemical binding]; other site
459424007238	active site
459424007239	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424007240	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424007241	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
459424007242	active site
459424007243	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424007244	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424007245	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424007246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424007247	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424007248	Enoylreductase; Region: PKS_ER; smart00829
459424007249	NAD(P) binding site [chemical binding]; other site
459424007250	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
459424007251	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424007252	putative NADP binding site [chemical binding]; other site
459424007253	active site
459424007254	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424007255	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
459424007256	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
459424007257	malonyl-CoA binding site [chemical binding]; other site
459424007258	dimer interface [polypeptide binding]; other site
459424007259	active site
459424007260	product binding site; other site
459424007261	argininosuccinate lyase; Provisional; Region: PRK00855
459424007262	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
459424007263	active sites [active]
459424007264	tetramer interface [polypeptide binding]; other site
459424007265	argininosuccinate synthase; Provisional; Region: PRK13820
459424007266	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
459424007267	ANP binding site [chemical binding]; other site
459424007268	Substrate Binding Site II [chemical binding]; other site
459424007269	Substrate Binding Site I [chemical binding]; other site
459424007270	arginine repressor; Provisional; Region: PRK03341
459424007271	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
459424007272	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
459424007273	ornithine carbamoyltransferase; Provisional; Region: PRK00779
459424007274	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
459424007275	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
459424007276	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
459424007277	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424007278	inhibitor-cofactor binding pocket; inhibition site
459424007279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424007280	catalytic residue [active]
459424007281	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
459424007282	feedback inhibition sensing region; other site
459424007283	homohexameric interface [polypeptide binding]; other site
459424007284	nucleotide binding site [chemical binding]; other site
459424007285	N-acetyl-L-glutamate binding site [chemical binding]; other site
459424007286	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
459424007287	heterotetramer interface [polypeptide binding]; other site
459424007288	active site pocket [active]
459424007289	cleavage site
459424007290	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
459424007291	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
459424007292	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007293	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007294	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007295	PE family; Region: PE; pfam00934
459424007296	PE family; Region: PE; pfam00934
459424007297	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
459424007298	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
459424007299	putative tRNA-binding site [nucleotide binding]; other site
459424007300	B3/4 domain; Region: B3_4; pfam03483
459424007301	tRNA synthetase B5 domain; Region: B5; pfam03484
459424007302	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
459424007303	dimer interface [polypeptide binding]; other site
459424007304	motif 1; other site
459424007305	motif 3; other site
459424007306	motif 2; other site
459424007307	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
459424007308	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
459424007309	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
459424007310	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
459424007311	dimer interface [polypeptide binding]; other site
459424007312	motif 1; other site
459424007313	active site
459424007314	motif 2; other site
459424007315	motif 3; other site
459424007316	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424007317	cyclase homology domain; Region: CHD; cd07302
459424007318	nucleotidyl binding site; other site
459424007319	metal binding site [ion binding]; metal-binding site
459424007320	dimer interface [polypeptide binding]; other site
459424007321	PE family; Region: PE; pfam00934
459424007322	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
459424007323	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
459424007324	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
459424007325	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
459424007326	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
459424007327	23S rRNA binding site [nucleotide binding]; other site
459424007328	L21 binding site [polypeptide binding]; other site
459424007329	L13 binding site [polypeptide binding]; other site
459424007330	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
459424007331	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
459424007332	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
459424007333	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
459424007334	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
459424007335	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
459424007336	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
459424007337	dimer interface [polypeptide binding]; other site
459424007338	putative anticodon binding site; other site
459424007339	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
459424007340	motif 1; other site
459424007341	dimer interface [polypeptide binding]; other site
459424007342	active site
459424007343	motif 2; other site
459424007344	motif 3; other site
459424007345	Predicted esterase [General function prediction only]; Region: COG0627
459424007346	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
459424007347	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
459424007348	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
459424007349	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
459424007350	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
459424007351	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
459424007352	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
459424007353	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424007354	Ligand Binding Site [chemical binding]; other site
459424007355	Predicted membrane protein [Function unknown]; Region: COG5305
459424007356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424007357	Major Facilitator Superfamily; Region: MFS_1; pfam07690
459424007358	putative substrate translocation pore; other site
459424007359	excinuclease ABC subunit B; Provisional; Region: PRK05298
459424007360	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
459424007361	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
459424007362	nucleotide binding region [chemical binding]; other site
459424007363	ATP-binding site [chemical binding]; other site
459424007364	Ultra-violet resistance protein B; Region: UvrB; pfam12344
459424007365	UvrB/uvrC motif; Region: UVR; pfam02151
459424007366	Protein of unknown function (DUF402); Region: DUF402; cl00979
459424007367	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
459424007368	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
459424007369	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
459424007370	CoA-binding site [chemical binding]; other site
459424007371	ATP-binding [chemical binding]; other site
459424007372	Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320
459424007373	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
459424007374	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
459424007375	RNA binding site [nucleotide binding]; other site
459424007376	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
459424007377	RNA binding site [nucleotide binding]; other site
459424007378	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
459424007379	RNA binding site [nucleotide binding]; other site
459424007380	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
459424007381	RNA binding site [nucleotide binding]; other site
459424007382	DNA polymerase I; Provisional; Region: PRK05755
459424007383	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
459424007384	active site
459424007385	metal binding site 1 [ion binding]; metal-binding site
459424007386	putative 5' ssDNA interaction site; other site
459424007387	metal binding site 3; metal-binding site
459424007388	metal binding site 2 [ion binding]; metal-binding site
459424007389	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
459424007390	putative DNA binding site [nucleotide binding]; other site
459424007391	putative metal binding site [ion binding]; other site
459424007392	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
459424007393	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
459424007394	active site
459424007395	DNA binding site [nucleotide binding]
459424007396	catalytic site [active]
459424007397	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
459424007398	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
459424007399	DUF35 OB-fold domain; Region: DUF35; pfam01796
459424007400	lipid-transfer protein; Provisional; Region: PRK06059
459424007401	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424007402	active site
459424007403	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
459424007404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424007405	active site
459424007406	phosphorylation site [posttranslational modification]
459424007407	intermolecular recognition site; other site
459424007408	dimerization interface [polypeptide binding]; other site
459424007409	ANTAR domain; Region: ANTAR; pfam03861
459424007410	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
459424007411	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
459424007412	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
459424007413	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
459424007414	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
459424007415	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
459424007416	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
459424007417	Walker A/P-loop; other site
459424007418	ATP binding site [chemical binding]; other site
459424007419	Q-loop/lid; other site
459424007420	ABC transporter signature motif; other site
459424007421	Walker B; other site
459424007422	D-loop; other site
459424007423	H-loop/switch region; other site
459424007424	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
459424007425	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
459424007426	Walker A/P-loop; other site
459424007427	ATP binding site [chemical binding]; other site
459424007428	Q-loop/lid; other site
459424007429	ABC transporter signature motif; other site
459424007430	Walker B; other site
459424007431	D-loop; other site
459424007432	H-loop/switch region; other site
459424007433	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
459424007434	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
459424007435	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
459424007436	active site
459424007437	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
459424007438	catalytic triad [active]
459424007439	dimer interface [polypeptide binding]; other site
459424007440	pyruvate kinase; Provisional; Region: PRK06247
459424007441	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
459424007442	domain interfaces; other site
459424007443	active site
459424007444	Cutinase; Region: Cutinase; pfam01083
459424007445	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
459424007446	TM2 domain; Region: TM2; pfam05154
459424007447	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
459424007448	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
459424007449	substrate binding site [chemical binding]; other site
459424007450	active site
459424007451	catalytic residues [active]
459424007452	heterodimer interface [polypeptide binding]; other site
459424007453	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
459424007454	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
459424007455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424007456	catalytic residue [active]
459424007457	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
459424007458	active site
459424007459	ribulose/triose binding site [chemical binding]; other site
459424007460	phosphate binding site [ion binding]; other site
459424007461	substrate (anthranilate) binding pocket [chemical binding]; other site
459424007462	product (indole) binding pocket [chemical binding]; other site
459424007463	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
459424007464	anthranilate synthase component I; Provisional; Region: PRK13571
459424007465	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
459424007466	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
459424007467	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007468	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
459424007469	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424007470	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424007471	active site
459424007472	ATP binding site [chemical binding]; other site
459424007473	substrate binding site [chemical binding]; other site
459424007474	activation loop (A-loop); other site
459424007475	Repair protein; Region: Repair_PSII; pfam04536
459424007476	amino acid transporter; Region: 2A0306; TIGR00909
459424007477	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
459424007478	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
459424007479	proposed catalytic triad [active]
459424007480	active site nucleophile [active]
459424007481	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
459424007482	conserved cys residue [active]
459424007483	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
459424007484	active site
459424007485	Zn binding site [ion binding]; other site
459424007486	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
459424007487	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
459424007488	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
459424007489	substrate binding site [chemical binding]; other site
459424007490	glutamase interaction surface [polypeptide binding]; other site
459424007491	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
459424007492	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
459424007493	active site
459424007494	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
459424007495	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
459424007496	catalytic residues [active]
459424007497	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
459424007498	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
459424007499	putative active site [active]
459424007500	oxyanion strand; other site
459424007501	catalytic triad [active]
459424007502	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
459424007503	4-fold oligomerization interface [polypeptide binding]; other site
459424007504	putative active site pocket [active]
459424007505	metal binding residues [ion binding]; metal-binding site
459424007506	3-fold/trimer interface [polypeptide binding]; other site
459424007507	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
459424007508	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424007509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424007510	homodimer interface [polypeptide binding]; other site
459424007511	catalytic residue [active]
459424007512	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
459424007513	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
459424007514	NAD binding site [chemical binding]; other site
459424007515	dimerization interface [polypeptide binding]; other site
459424007516	product binding site; other site
459424007517	substrate binding site [chemical binding]; other site
459424007518	zinc binding site [ion binding]; other site
459424007519	catalytic residues [active]
459424007520	Domain of unknown function (DUF385); Region: DUF385; cl04387
459424007521	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
459424007522	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
459424007523	dimerization interface [polypeptide binding]; other site
459424007524	active site
459424007525	L-aspartate oxidase; Provisional; Region: PRK07804
459424007526	L-aspartate oxidase; Provisional; Region: PRK06175
459424007527	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
459424007528	quinolinate synthetase; Provisional; Region: PRK09375
459424007529	Secretory lipase; Region: LIP; pfam03583
459424007530	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
459424007531	biotin synthase; Validated; Region: PRK06256
459424007532	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424007533	FeS/SAM binding site; other site
459424007534	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
459424007535	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
459424007536	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
459424007537	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
459424007538	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
459424007539	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424007540	catalytic residue [active]
459424007541	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
459424007542	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424007543	inhibitor-cofactor binding pocket; inhibition site
459424007544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424007545	catalytic residue [active]
459424007546	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
459424007547	NlpC/P60 family; Region: NLPC_P60; pfam00877
459424007548	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
459424007549	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
459424007550	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
459424007551	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
459424007552	active site
459424007553	catalytic site [active]
459424007554	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
459424007555	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
459424007556	active site
459424007557	catalytic site [active]
459424007558	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
459424007559	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
459424007560	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
459424007561	catalytic site [active]
459424007562	active site
459424007563	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
459424007564	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
459424007565	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424007566	DNA-binding site [nucleotide binding]; DNA binding site
459424007567	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424007568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424007569	homodimer interface [polypeptide binding]; other site
459424007570	catalytic residue [active]
459424007571	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
459424007572	threonine dehydratase; Validated; Region: PRK08639
459424007573	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
459424007574	tetramer interface [polypeptide binding]; other site
459424007575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424007576	catalytic residue [active]
459424007577	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
459424007578	Domain of unknown function (DUF385); Region: DUF385; pfam04075
459424007579	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
459424007580	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
459424007581	acyl-activating enzyme (AAE) consensus motif; other site
459424007582	putative AMP binding site [chemical binding]; other site
459424007583	putative active site [active]
459424007584	putative CoA binding site [chemical binding]; other site
459424007585	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
459424007586	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
459424007587	active site
459424007588	PHP Thumb interface [polypeptide binding]; other site
459424007589	metal binding site [ion binding]; metal-binding site
459424007590	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
459424007591	generic binding surface II; other site
459424007592	generic binding surface I; other site
459424007593	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
459424007594	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424007595	NAD(P) binding site [chemical binding]; other site
459424007596	active site
459424007597	short chain dehydrogenase; Provisional; Region: PRK05866
459424007598	classical (c) SDRs; Region: SDR_c; cd05233
459424007599	NAD(P) binding site [chemical binding]; other site
459424007600	active site
459424007601	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
459424007602	apolar tunnel; other site
459424007603	heme binding site [chemical binding]; other site
459424007604	dimerization interface [polypeptide binding]; other site
459424007605	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
459424007606	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
459424007607	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
459424007608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424007609	S-adenosylmethionine binding site [chemical binding]; other site
459424007610	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
459424007611	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
459424007612	active site
459424007613	lipoprotein signal peptidase; Provisional; Region: PRK14764
459424007614	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
459424007615	active site
459424007616	homodimer interface [polypeptide binding]; other site
459424007617	homotetramer interface [polypeptide binding]; other site
459424007618	DNA polymerase IV; Provisional; Region: PRK03348
459424007619	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
459424007620	active site
459424007621	DNA binding site [nucleotide binding]
459424007622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424007623	S-adenosylmethionine binding site [chemical binding]; other site
459424007624	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
459424007625	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
459424007626	HIGH motif; other site
459424007627	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
459424007628	active site
459424007629	KMSKS motif; other site
459424007630	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
459424007631	tRNA binding surface [nucleotide binding]; other site
459424007632	anticodon binding site; other site
459424007633	Condensation domain; Region: Condensation; pfam00668
459424007634	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424007635	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007636	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007637	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007638	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
459424007639	homodimer interface [polypeptide binding]; other site
459424007640	active site
459424007641	TDP-binding site; other site
459424007642	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
459424007643	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
459424007644	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
459424007645	active site
459424007646	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424007647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424007648	S-adenosylmethionine binding site [chemical binding]; other site
459424007649	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
459424007650	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
459424007651	Probable Catalytic site; other site
459424007652	metal-binding site
459424007653	Nitronate monooxygenase; Region: NMO; pfam03060
459424007654	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
459424007655	FMN binding site [chemical binding]; other site
459424007656	substrate binding site [chemical binding]; other site
459424007657	putative catalytic residue [active]
459424007658	Uncharacterized conserved protein [Function unknown]; Region: COG2128
459424007659	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
459424007660	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
459424007661	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424007662	active site
459424007663	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424007664	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
459424007665	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424007666	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
459424007667	Enoylreductase; Region: PKS_ER; smart00829
459424007668	NAD(P) binding site [chemical binding]; other site
459424007669	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
459424007670	KR domain; Region: KR; pfam08659
459424007671	putative NADP binding site [chemical binding]; other site
459424007672	active site
459424007673	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424007674	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424007675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424007676	S-adenosylmethionine binding site [chemical binding]; other site
459424007677	Predicted membrane protein [Function unknown]; Region: COG2246
459424007678	GtrA-like protein; Region: GtrA; pfam04138
459424007679	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
459424007680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424007681	NAD(P) binding site [chemical binding]; other site
459424007682	active site
459424007683	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
459424007684	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
459424007685	inhibitor-cofactor binding pocket; inhibition site
459424007686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424007687	catalytic residue [active]
459424007688	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
459424007689	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
459424007690	substrate binding site; other site
459424007691	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
459424007692	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
459424007693	Ligand binding site; other site
459424007694	Putative Catalytic site; other site
459424007695	DXD motif; other site
459424007696	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
459424007697	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
459424007698	PYR/PP interface [polypeptide binding]; other site
459424007699	dimer interface [polypeptide binding]; other site
459424007700	TPP binding site [chemical binding]; other site
459424007701	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
459424007702	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
459424007703	TPP-binding site [chemical binding]; other site
459424007704	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424007705	classical (c) SDRs; Region: SDR_c; cd05233
459424007706	NAD(P) binding site [chemical binding]; other site
459424007707	active site
459424007708	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
459424007709	active site
459424007710	NAD binding site [chemical binding]; other site
459424007711	metal binding site [ion binding]; metal-binding site
459424007712	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
459424007713	nucleotide binding site [chemical binding]; other site
459424007714	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007715	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007716	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007717	WbqC-like protein family; Region: WbqC; pfam08889
459424007718	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424007719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424007720	NAD(P) binding site [chemical binding]; other site
459424007721	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424007722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424007723	S-adenosylmethionine binding site [chemical binding]; other site
459424007724	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
459424007725	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
459424007726	active site
459424007727	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424007728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424007729	NAD(P) binding site [chemical binding]; other site
459424007730	active site
459424007731	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
459424007732	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
459424007733	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
459424007734	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
459424007735	GtrA-like protein; Region: GtrA; pfam04138
459424007736	Dodecin; Region: Dodecin; pfam07311
459424007737	Beta-lactamase; Region: Beta-lactamase; pfam00144
459424007738	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424007739	membrane ATPase/protein kinase; Provisional; Region: PRK09435
459424007740	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
459424007741	Walker A; other site
459424007742	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
459424007743	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
459424007744	active site
459424007745	substrate binding site [chemical binding]; other site
459424007746	coenzyme B12 binding site [chemical binding]; other site
459424007747	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
459424007748	B12 binding site [chemical binding]; other site
459424007749	cobalt ligand [ion binding]; other site
459424007750	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
459424007751	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
459424007752	heterodimer interface [polypeptide binding]; other site
459424007753	substrate interaction site [chemical binding]; other site
459424007754	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
459424007755	Uncharacterized conserved protein [Function unknown]; Region: COG0398
459424007756	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
459424007757	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
459424007758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
459424007759	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
459424007760	dimer interface [polypeptide binding]; other site
459424007761	phosphorylation site [posttranslational modification]
459424007762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424007763	ATP binding site [chemical binding]; other site
459424007764	Mg2+ binding site [ion binding]; other site
459424007765	G-X-G motif; other site
459424007766	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424007767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424007768	active site
459424007769	phosphorylation site [posttranslational modification]
459424007770	intermolecular recognition site; other site
459424007771	dimerization interface [polypeptide binding]; other site
459424007772	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424007773	DNA binding site [nucleotide binding]
459424007774	ferrochelatase; Reviewed; Region: hemH; PRK00035
459424007775	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
459424007776	C-terminal domain interface [polypeptide binding]; other site
459424007777	active site
459424007778	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
459424007779	active site
459424007780	N-terminal domain interface [polypeptide binding]; other site
459424007781	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
459424007782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424007783	NAD(P) binding site [chemical binding]; other site
459424007784	active site
459424007785	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
459424007786	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
459424007787	NAD(P) binding site [chemical binding]; other site
459424007788	homotetramer interface [polypeptide binding]; other site
459424007789	homodimer interface [polypeptide binding]; other site
459424007790	active site
459424007791	hypothetical protein; Provisional; Region: PRK13685
459424007792	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
459424007793	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
459424007794	metal ion-dependent adhesion site (MIDAS); other site
459424007795	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
459424007796	Protein of unknown function DUF58; Region: DUF58; pfam01882
459424007797	MoxR-like ATPases [General function prediction only]; Region: COG0714
459424007798	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424007799	Walker A motif; other site
459424007800	ATP binding site [chemical binding]; other site
459424007801	Walker B motif; other site
459424007802	arginine finger; other site
459424007803	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
459424007804	NlpC/P60 family; Region: NLPC_P60; pfam00877
459424007805	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
459424007806	NlpC/P60 family; Region: NLPC_P60; pfam00877
459424007807	aconitate hydratase; Validated; Region: PRK09277
459424007808	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
459424007809	substrate binding site [chemical binding]; other site
459424007810	ligand binding site [chemical binding]; other site
459424007811	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
459424007812	substrate binding site [chemical binding]; other site
459424007813	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424007814	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424007815	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
459424007816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424007817	Walker A/P-loop; other site
459424007818	ATP binding site [chemical binding]; other site
459424007819	Q-loop/lid; other site
459424007820	ABC transporter signature motif; other site
459424007821	Walker B; other site
459424007822	D-loop; other site
459424007823	H-loop/switch region; other site
459424007824	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
459424007825	enoyl-CoA hydratase; Provisional; Region: PRK05864
459424007826	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424007827	substrate binding site [chemical binding]; other site
459424007828	oxyanion hole (OAH) forming residues; other site
459424007829	trimer interface [polypeptide binding]; other site
459424007830	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
459424007831	catalytic residues [active]
459424007832	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
459424007833	catalytic residues [active]
459424007834	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007835	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007836	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007837	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
459424007838	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
459424007839	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424007840	active site
459424007841	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
459424007842	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007843	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007844	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007845	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
459424007846	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
459424007847	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
459424007848	trimerization site [polypeptide binding]; other site
459424007849	active site
459424007850	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
459424007851	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
459424007852	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424007853	catalytic residue [active]
459424007854	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
459424007855	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
459424007856	Walker A/P-loop; other site
459424007857	ATP binding site [chemical binding]; other site
459424007858	Q-loop/lid; other site
459424007859	ABC transporter signature motif; other site
459424007860	Walker B; other site
459424007861	D-loop; other site
459424007862	H-loop/switch region; other site
459424007863	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
459424007864	FeS assembly protein SufD; Region: sufD; TIGR01981
459424007865	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
459424007866	FeS assembly protein SufB; Region: sufB; TIGR01980
459424007867	Predicted transcriptional regulator [Transcription]; Region: COG2345
459424007868	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424007869	putative Zn2+ binding site [ion binding]; other site
459424007870	putative DNA binding site [nucleotide binding]; other site
459424007871	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
459424007872	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
459424007873	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
459424007874	Walker A/P-loop; other site
459424007875	ATP binding site [chemical binding]; other site
459424007876	Q-loop/lid; other site
459424007877	ABC transporter signature motif; other site
459424007878	Walker B; other site
459424007879	D-loop; other site
459424007880	H-loop/switch region; other site
459424007881	ABC-2 type transporter; Region: ABC2_membrane; cl17235
459424007882	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
459424007883	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
459424007884	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
459424007885	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
459424007886	NADP binding site [chemical binding]; other site
459424007887	dimer interface [polypeptide binding]; other site
459424007888	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
459424007889	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424007890	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
459424007891	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
459424007892	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
459424007893	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
459424007894	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
459424007895	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007896	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007897	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007898	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424007899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424007900	putative substrate translocation pore; other site
459424007901	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424007902	mercuric reductase; Validated; Region: PRK06370
459424007903	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
459424007904	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424007905	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
459424007906	Predicted membrane protein [Function unknown]; Region: COG3918
459424007907	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
459424007908	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
459424007909	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
459424007910	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
459424007911	homodimer interface [polypeptide binding]; other site
459424007912	putative metal binding site [ion binding]; other site
459424007913	PE family; Region: PE; pfam00934
459424007914	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424007915	PPE family; Region: PPE; pfam00823
459424007916	PAC2 family; Region: PAC2; pfam09754
459424007917	hypothetical protein; Provisional; Region: PRK07588
459424007918	hypothetical protein; Provisional; Region: PRK07236
459424007919	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424007920	short chain dehydrogenase; Provisional; Region: PRK05872
459424007921	classical (c) SDRs; Region: SDR_c; cd05233
459424007922	NAD(P) binding site [chemical binding]; other site
459424007923	active site
459424007924	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
459424007925	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
459424007926	active site
459424007927	HIGH motif; other site
459424007928	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
459424007929	active site
459424007930	KMSKS motif; other site
459424007931	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
459424007932	putative tRNA binding surface [nucleotide binding]; other site
459424007933	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007934	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007935	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007936	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
459424007937	active site
459424007938	conserved hypothetical protein; Region: TIGR03843
459424007939	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
459424007940	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424007941	catalytic core [active]
459424007942	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
459424007943	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
459424007944	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
459424007945	quinone interaction residues [chemical binding]; other site
459424007946	active site
459424007947	catalytic residues [active]
459424007948	FMN binding site [chemical binding]; other site
459424007949	substrate binding site [chemical binding]; other site
459424007950	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424007951	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424007952	active site
459424007953	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
459424007954	substrate binding site [chemical binding]; other site
459424007955	hypothetical protein; Provisional; Region: PRK07906
459424007956	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
459424007957	putative metal binding site [ion binding]; other site
459424007958	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007959	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007960	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007961	MbtH-like protein; Region: MbtH; pfam03621
459424007962	Transport protein; Region: actII; TIGR00833
459424007963	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424007964	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007965	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007966	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007967	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424007968	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424007969	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424007970	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424007971	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
459424007972	putative active site [active]
459424007973	DivIVA domain; Region: DivI1A_domain; TIGR03544
459424007974	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
459424007975	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
459424007976	Predicted integral membrane protein [Function unknown]; Region: COG0762
459424007977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
459424007978	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
459424007979	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
459424007980	catalytic residue [active]
459424007981	cell division protein FtsZ; Validated; Region: PRK09330
459424007982	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
459424007983	nucleotide binding site [chemical binding]; other site
459424007984	SulA interaction site; other site
459424007985	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
459424007986	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
459424007987	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
459424007988	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
459424007989	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
459424007990	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
459424007991	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
459424007992	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
459424007993	active site
459424007994	homodimer interface [polypeptide binding]; other site
459424007995	cell division protein FtsW; Region: ftsW; TIGR02614
459424007996	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
459424007997	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
459424007998	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
459424007999	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
459424008000	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
459424008001	Mg++ binding site [ion binding]; other site
459424008002	putative catalytic motif [active]
459424008003	putative substrate binding site [chemical binding]; other site
459424008004	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
459424008005	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
459424008006	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
459424008007	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
459424008008	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
459424008009	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
459424008010	PE family; Region: PE; pfam00934
459424008011	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
459424008012	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
459424008013	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
459424008014	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
459424008015	MraW methylase family; Region: Methyltransf_5; cl17771
459424008016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
459424008017	MraZ protein; Region: MraZ; pfam02381
459424008018	MraZ protein; Region: MraZ; pfam02381
459424008019	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
459424008020	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
459424008021	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
459424008022	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
459424008023	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
459424008024	substrate binding pocket [chemical binding]; other site
459424008025	chain length determination region; other site
459424008026	substrate-Mg2+ binding site; other site
459424008027	catalytic residues [active]
459424008028	aspartate-rich region 1; other site
459424008029	active site lid residues [active]
459424008030	aspartate-rich region 2; other site
459424008031	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
459424008032	Helix-turn-helix domain; Region: HTH_17; cl17695
459424008033	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424008034	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424008035	active site
459424008036	ATP binding site [chemical binding]; other site
459424008037	substrate binding site [chemical binding]; other site
459424008038	activation loop (A-loop); other site
459424008039	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
459424008040	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
459424008041	dimer interface [polypeptide binding]; other site
459424008042	active site
459424008043	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
459424008044	homodimer interface [polypeptide binding]; other site
459424008045	substrate binding pocket [chemical binding]; other site
459424008046	catalytic residues [active]
459424008047	NADH/NADPH cofactor binding site [chemical binding]; other site
459424008048	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
459424008049	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
459424008050	diphosphomevalonate decarboxylase; Region: PLN02407
459424008051	diphosphomevalonate decarboxylase; Region: PLN02407
459424008052	mevalonate kinase; Region: mevalon_kin; TIGR00549
459424008053	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
459424008054	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
459424008055	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
459424008056	active site
459424008057	metal binding site [ion binding]; metal-binding site
459424008058	nudix motif; other site
459424008059	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
459424008060	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
459424008061	substrate binding pocket [chemical binding]; other site
459424008062	chain length determination region; other site
459424008063	substrate-Mg2+ binding site; other site
459424008064	catalytic residues [active]
459424008065	aspartate-rich region 1; other site
459424008066	active site lid residues [active]
459424008067	aspartate-rich region 2; other site
459424008068	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
459424008069	substrate binding pocket [chemical binding]; other site
459424008070	substrate-Mg2+ binding site; other site
459424008071	aspartate-rich region 1; other site
459424008072	aspartate-rich region 2; other site
459424008073	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
459424008074	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
459424008075	dimer interface [polypeptide binding]; other site
459424008076	active site
459424008077	CoA binding pocket [chemical binding]; other site
459424008078	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
459424008079	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424008080	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
459424008081	putative acyl-acceptor binding pocket; other site
459424008082	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
459424008083	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
459424008084	DTAP/Switch II; other site
459424008085	Switch I; other site
459424008086	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
459424008087	putative hydrophobic ligand binding site [chemical binding]; other site
459424008088	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
459424008089	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
459424008090	acyl-activating enzyme (AAE) consensus motif; other site
459424008091	putative AMP binding site [chemical binding]; other site
459424008092	putative active site [active]
459424008093	putative CoA binding site [chemical binding]; other site
459424008094	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
459424008095	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424008096	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
459424008097	NlpC/P60 family; Region: NLPC_P60; pfam00877
459424008098	hypothetical protein; Validated; Region: PRK07883
459424008099	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
459424008100	active site
459424008101	substrate binding site [chemical binding]; other site
459424008102	catalytic site [active]
459424008103	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
459424008104	GIY-YIG motif/motif A; other site
459424008105	active site
459424008106	catalytic site [active]
459424008107	putative DNA binding site [nucleotide binding]; other site
459424008108	metal binding site [ion binding]; metal-binding site
459424008109	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
459424008110	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
459424008111	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
459424008112	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
459424008113	Subunit I/III interface [polypeptide binding]; other site
459424008114	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
459424008115	Cytochrome c; Region: Cytochrom_C; pfam00034
459424008116	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
459424008117	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
459424008118	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
459424008119	iron-sulfur cluster [ion binding]; other site
459424008120	[2Fe-2S] cluster binding site [ion binding]; other site
459424008121	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
459424008122	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
459424008123	heme bH binding site [chemical binding]; other site
459424008124	intrachain domain interface; other site
459424008125	heme bL binding site [chemical binding]; other site
459424008126	interchain domain interface [polypeptide binding]; other site
459424008127	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
459424008128	Qo binding site; other site
459424008129	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
459424008130	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
459424008131	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
459424008132	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
459424008133	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
459424008134	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
459424008135	dimer interface [polypeptide binding]; other site
459424008136	active site
459424008137	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
459424008138	Ligand Binding Site [chemical binding]; other site
459424008139	Molecular Tunnel; other site
459424008140	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
459424008141	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
459424008142	substrate binding site [chemical binding]; other site
459424008143	ATP binding site [chemical binding]; other site
459424008144	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
459424008145	Glycerate kinase family; Region: Gly_kinase; pfam02595
459424008146	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
459424008147	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
459424008148	homotrimer interface [polypeptide binding]; other site
459424008149	Walker A motif; other site
459424008150	GTP binding site [chemical binding]; other site
459424008151	Walker B motif; other site
459424008152	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
459424008153	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
459424008154	active site pocket [active]
459424008155	putative dimer interface [polypeptide binding]; other site
459424008156	putative cataytic base [active]
459424008157	cobalamin synthase; Reviewed; Region: cobS; PRK00235
459424008158	MFS/sugar transport protein; Region: MFS_2; pfam13347
459424008159	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
459424008160	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
459424008161	homodimer interface [polypeptide binding]; other site
459424008162	substrate-cofactor binding pocket; other site
459424008163	catalytic residue [active]
459424008164	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
459424008165	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
459424008166	multifunctional aminopeptidase A; Provisional; Region: PRK00913
459424008167	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
459424008168	interface (dimer of trimers) [polypeptide binding]; other site
459424008169	Substrate-binding/catalytic site; other site
459424008170	Zn-binding sites [ion binding]; other site
459424008171	short chain dehydrogenase; Validated; Region: PRK05855
459424008172	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424008173	classical (c) SDRs; Region: SDR_c; cd05233
459424008174	NAD(P) binding site [chemical binding]; other site
459424008175	active site
459424008176	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
459424008177	E3 interaction surface; other site
459424008178	lipoyl attachment site [posttranslational modification]; other site
459424008179	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
459424008180	E3 interaction surface; other site
459424008181	lipoyl attachment site [posttranslational modification]; other site
459424008182	e3 binding domain; Region: E3_binding; pfam02817
459424008183	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
459424008184	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
459424008185	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
459424008186	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
459424008187	putative NAD(P) binding site [chemical binding]; other site
459424008188	putative active site [active]
459424008189	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008190	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424008191	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008192	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008193	PA26 p53-induced protein (sestrin); Region: PA26; pfam04636
459424008194	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
459424008195	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
459424008196	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
459424008197	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424008198	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424008199	DNA binding residues [nucleotide binding]
459424008200	Putative zinc-finger; Region: zf-HC2; pfam13490
459424008201	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
459424008202	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
459424008203	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
459424008204	acetolactate synthase; Reviewed; Region: PRK08322
459424008205	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
459424008206	PYR/PP interface [polypeptide binding]; other site
459424008207	dimer interface [polypeptide binding]; other site
459424008208	TPP binding site [chemical binding]; other site
459424008209	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
459424008210	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
459424008211	TPP-binding site [chemical binding]; other site
459424008212	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
459424008213	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
459424008214	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
459424008215	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
459424008216	Walker A/P-loop; other site
459424008217	ATP binding site [chemical binding]; other site
459424008218	Q-loop/lid; other site
459424008219	ABC transporter signature motif; other site
459424008220	Walker B; other site
459424008221	D-loop; other site
459424008222	H-loop/switch region; other site
459424008223	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
459424008224	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
459424008225	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424008226	Walker A/P-loop; other site
459424008227	ATP binding site [chemical binding]; other site
459424008228	Q-loop/lid; other site
459424008229	ABC transporter signature motif; other site
459424008230	Walker B; other site
459424008231	D-loop; other site
459424008232	H-loop/switch region; other site
459424008233	lipoate-protein ligase B; Provisional; Region: PRK14345
459424008234	lipoyl synthase; Provisional; Region: PRK05481
459424008235	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424008236	FeS/SAM binding site; other site
459424008237	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
459424008238	RDD family; Region: RDD; pfam06271
459424008239	glutamine synthetase, type I; Region: GlnA; TIGR00653
459424008240	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
459424008241	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
459424008242	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424008243	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424008244	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
459424008245	CoenzymeA binding site [chemical binding]; other site
459424008246	subunit interaction site [polypeptide binding]; other site
459424008247	PHB binding site; other site
459424008248	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
459424008249	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
459424008250	metal binding triad; other site
459424008251	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
459424008252	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
459424008253	metal binding triad; other site
459424008254	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
459424008255	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
459424008256	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
459424008257	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
459424008258	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
459424008259	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424008260	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
459424008261	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
459424008262	D-pathway; other site
459424008263	Putative ubiquinol binding site [chemical binding]; other site
459424008264	Low-spin heme (heme b) binding site [chemical binding]; other site
459424008265	Putative water exit pathway; other site
459424008266	Binuclear center (heme o3/CuB) [ion binding]; other site
459424008267	K-pathway; other site
459424008268	Putative proton exit pathway; other site
459424008269	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
459424008270	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424008271	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424008272	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424008273	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
459424008274	oligomerization interface [polypeptide binding]; other site
459424008275	active site
459424008276	metal binding site [ion binding]; metal-binding site
459424008277	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
459424008278	putative active site; other site
459424008279	putative metal binding residues [ion binding]; other site
459424008280	signature motif; other site
459424008281	putative triphosphate binding site [ion binding]; other site
459424008282	CHAD domain; Region: CHAD; pfam05235
459424008283	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
459424008284	PE family; Region: PE; pfam00934
459424008285	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
459424008286	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
459424008287	RNA/DNA hybrid binding site [nucleotide binding]; other site
459424008288	active site
459424008289	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424008290	catalytic core [active]
459424008291	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
459424008292	Putative zinc ribbon domain; Region: DUF164; pfam02591
459424008293	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
459424008294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
459424008295	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
459424008296	hypothetical protein; Provisional; Region: PRK07908
459424008297	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424008298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424008299	homodimer interface [polypeptide binding]; other site
459424008300	catalytic residue [active]
459424008301	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
459424008302	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424008303	motif II; other site
459424008304	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
459424008305	Low molecular weight phosphatase family; Region: LMWPc; cd00115
459424008306	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
459424008307	active site
459424008308	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
459424008309	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
459424008310	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
459424008311	Cation efflux family; Region: Cation_efflux; cl00316
459424008312	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
459424008313	Epoxide hydrolase N terminus; Region: EHN; pfam06441
459424008314	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424008315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424008316	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424008317	NAD(P) binding site [chemical binding]; other site
459424008318	active site
459424008319	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
459424008320	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
459424008321	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
459424008322	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424008323	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
459424008324	active site
459424008325	metal binding site [ion binding]; metal-binding site
459424008326	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424008327	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
459424008328	active site
459424008329	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
459424008330	putative hydrophobic ligand binding site [chemical binding]; other site
459424008331	protein interface [polypeptide binding]; other site
459424008332	gate; other site
459424008333	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
459424008334	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
459424008335	PYR/PP interface [polypeptide binding]; other site
459424008336	dimer interface [polypeptide binding]; other site
459424008337	TPP binding site [chemical binding]; other site
459424008338	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
459424008339	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
459424008340	TPP-binding site [chemical binding]; other site
459424008341	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424008342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424008343	NAD(P) binding site [chemical binding]; other site
459424008344	active site
459424008345	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
459424008346	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
459424008347	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
459424008348	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
459424008349	putative NAD(P) binding site [chemical binding]; other site
459424008350	catalytic Zn binding site [ion binding]; other site
459424008351	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424008352	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424008353	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424008354	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424008355	Fic family protein [Function unknown]; Region: COG3177
459424008356	Fic/DOC family; Region: Fic; pfam02661
459424008357	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424008358	Cytochrome P450; Region: p450; cl12078
459424008359	Orotate phosphoribosyltransferase homologs [Nucleotide transport and metabolism]; Region: COG0856
459424008360	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
459424008361	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
459424008362	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
459424008363	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
459424008364	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
459424008365	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
459424008366	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
459424008367	NADH dehydrogenase; Region: NADHdh; cl00469
459424008368	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
459424008369	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
459424008370	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424008371	dimerization interface [polypeptide binding]; other site
459424008372	putative DNA binding site [nucleotide binding]; other site
459424008373	putative Zn2+ binding site [ion binding]; other site
459424008374	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008375	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008376	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008377	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
459424008378	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
459424008379	dinuclear metal binding motif [ion binding]; other site
459424008380	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
459424008381	active site
459424008382	NTP binding site [chemical binding]; other site
459424008383	metal binding triad [ion binding]; metal-binding site
459424008384	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
459424008385	TrwC relaxase; Region: TrwC; pfam08751
459424008386	AAA domain; Region: AAA_30; pfam13604
459424008387	Family description; Region: UvrD_C_2; pfam13538
459424008388	Helix-turn-helix domain; Region: HTH_17; pfam12728
459424008389	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
459424008390	Int/Topo IB signature motif; other site
459424008391	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
459424008392	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
459424008393	tetramer interface [polypeptide binding]; other site
459424008394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424008395	catalytic residue [active]
459424008396	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
459424008397	Predicted transcriptional regulators [Transcription]; Region: COG1733
459424008398	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
459424008399	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
459424008400	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
459424008401	dimer interface [polypeptide binding]; other site
459424008402	catalytic triad [active]
459424008403	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
459424008404	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
459424008405	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
459424008406	dimer interface [polypeptide binding]; other site
459424008407	TPP-binding site [chemical binding]; other site
459424008408	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
459424008409	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424008410	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
459424008411	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424008412	acyl carrier protein; Provisional; Region: acpP; PRK00982
459424008413	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
459424008414	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
459424008415	dimer interface [polypeptide binding]; other site
459424008416	active site
459424008417	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
459424008418	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
459424008419	dimer interface [polypeptide binding]; other site
459424008420	active site
459424008421	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
459424008422	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
459424008423	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
459424008424	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
459424008425	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424008426	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424008427	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
459424008428	FAD binding domain; Region: FAD_binding_4; pfam01565
459424008429	diacylglycerol kinase; Reviewed; Region: PRK11914
459424008430	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
459424008431	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008432	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008433	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008434	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
459424008435	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424008436	Beta-lactamase; Region: Beta-lactamase; pfam00144
459424008437	Methyltransferase domain; Region: Methyltransf_31; pfam13847
459424008438	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424008439	S-adenosylmethionine binding site [chemical binding]; other site
459424008440	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
459424008441	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
459424008442	NAD binding site [chemical binding]; other site
459424008443	catalytic Zn binding site [ion binding]; other site
459424008444	substrate binding site [chemical binding]; other site
459424008445	structural Zn binding site [ion binding]; other site
459424008446	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
459424008447	Short C-terminal domain; Region: SHOCT; pfam09851
459424008448	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
459424008449	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
459424008450	putative active site [active]
459424008451	catalytic triad [active]
459424008452	putative dimer interface [polypeptide binding]; other site
459424008453	short chain dehydrogenase; Provisional; Region: PRK05854
459424008454	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
459424008455	putative NAD(P) binding site [chemical binding]; other site
459424008456	active site
459424008457	SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109
459424008458	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
459424008459	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
459424008460	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424008461	Cytochrome P450; Region: p450; cl12078
459424008462	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424008463	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008464	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
459424008465	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424008466	hydroxyglutarate oxidase; Provisional; Region: PRK11728
459424008467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424008468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424008469	S-adenosylmethionine binding site [chemical binding]; other site
459424008470	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
459424008471	Predicted membrane protein [Function unknown]; Region: COG2149
459424008472	Domain of unknown function (DUF202); Region: DUF202; pfam02656
459424008473	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008474	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008475	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008476	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
459424008477	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
459424008478	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
459424008479	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
459424008480	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
459424008481	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008482	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008483	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008484	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
459424008485	Beta-lactamase; Region: Beta-lactamase; pfam00144
459424008486	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424008487	biotin carboxylase-like protein; Validated; Region: PRK06524
459424008488	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
459424008489	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424008490	Domain of unknown function (DUF385); Region: DUF385; cl04387
459424008491	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424008492	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424008493	S-adenosylmethionine binding site [chemical binding]; other site
459424008494	hypothetical protein; Provisional; Region: PRK06185
459424008495	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424008496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424008497	S-adenosylmethionine binding site [chemical binding]; other site
459424008498	Domain of unknown function (DUF385); Region: DUF385; cl04387
459424008499	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
459424008500	PE family; Region: PE; pfam00934
459424008501	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424008502	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424008503	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
459424008504	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424008505	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424008506	4Fe-4S binding domain; Region: Fer4; pfam00037
459424008507	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
459424008508	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
459424008509	dimer interface [polypeptide binding]; other site
459424008510	PYR/PP interface [polypeptide binding]; other site
459424008511	TPP binding site [chemical binding]; other site
459424008512	substrate binding site [chemical binding]; other site
459424008513	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
459424008514	Domain of unknown function; Region: EKR; smart00890
459424008515	4Fe-4S binding domain; Region: Fer4_6; pfam12837
459424008516	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
459424008517	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
459424008518	TPP-binding site [chemical binding]; other site
459424008519	dimer interface [polypeptide binding]; other site
459424008520	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
459424008521	phosphate binding site [ion binding]; other site
459424008522	phosphoenolpyruvate synthase; Validated; Region: PRK06464
459424008523	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
459424008524	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
459424008525	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
459424008526	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
459424008527	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
459424008528	active site
459424008529	ADP/pyrophosphate binding site [chemical binding]; other site
459424008530	dimerization interface [polypeptide binding]; other site
459424008531	allosteric effector site; other site
459424008532	fructose-1,6-bisphosphate binding site; other site
459424008533	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424008534	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
459424008535	active site
459424008536	metal binding site [ion binding]; metal-binding site
459424008537	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
459424008538	FAD binding domain; Region: FAD_binding_4; pfam01565
459424008539	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
459424008540	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
459424008541	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
459424008542	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
459424008543	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
459424008544	Active Sites [active]
459424008545	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
459424008546	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
459424008547	putative active site [active]
459424008548	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
459424008549	putative active site [active]
459424008550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
459424008551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
459424008552	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
459424008553	dimerization interface [polypeptide binding]; other site
459424008554	ferredoxin-NADP+ reductase; Region: PLN02852
459424008555	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
459424008556	4Fe-4S binding domain; Region: Fer4; cl02805
459424008557	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424008558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424008559	PE family; Region: PE; pfam00934
459424008560	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
459424008561	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424008562	putative acyl-acceptor binding pocket; other site
459424008563	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008564	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008565	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008566	Tocopherol cyclase; Region: Tocopherol_cycl; cl14571
459424008567	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424008568	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424008569	active site
459424008570	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
459424008571	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
459424008572	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
459424008573	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
459424008574	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
459424008575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424008576	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
459424008577	hypothetical protein; Provisional; Region: PRK06834
459424008578	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424008579	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
459424008580	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424008581	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
459424008582	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424008583	PPE family; Region: PPE; pfam00823
459424008584	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424008585	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
459424008586	Soybean trypsin inhibitor (Kunitz) family of protease inhibitors. Inhibit proteases by binding with high affinity to their active sites. Trefoil fold, common to interleukins and fibroblast growth factors; Region: STI; cl11466
459424008587	Peptidase family M23; Region: Peptidase_M23; pfam01551
459424008588	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
459424008589	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424008590	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424008591	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424008592	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
459424008593	active site
459424008594	metal binding site [ion binding]; metal-binding site
459424008595	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
459424008596	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
459424008597	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
459424008598	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
459424008599	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424008600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424008601	homodimer interface [polypeptide binding]; other site
459424008602	catalytic residue [active]
459424008603	Predicted transcriptional regulators [Transcription]; Region: COG1695
459424008604	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
459424008605	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
459424008606	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
459424008607	active site
459424008608	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
459424008609	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
459424008610	active site
459424008611	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424008612	dimer interface [polypeptide binding]; other site
459424008613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
459424008614	Predicted kinase [General function prediction only]; Region: COG0645
459424008615	AAA domain; Region: AAA_17; pfam13207
459424008616	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424008617	Ligand Binding Site [chemical binding]; other site
459424008618	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424008619	Ligand Binding Site [chemical binding]; other site
459424008620	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424008621	Ligand Binding Site [chemical binding]; other site
459424008622	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424008623	Ligand Binding Site [chemical binding]; other site
459424008624	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
459424008625	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
459424008626	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
459424008627	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
459424008628	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
459424008629	Histidine kinase; Region: HisKA_3; pfam07730
459424008630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424008631	ATP binding site [chemical binding]; other site
459424008632	Mg2+ binding site [ion binding]; other site
459424008633	G-X-G motif; other site
459424008634	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
459424008635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424008636	active site
459424008637	phosphorylation site [posttranslational modification]
459424008638	intermolecular recognition site; other site
459424008639	dimerization interface [polypeptide binding]; other site
459424008640	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
459424008641	DNA binding residues [nucleotide binding]
459424008642	dimerization interface [polypeptide binding]; other site
459424008643	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424008644	Ligand Binding Site [chemical binding]; other site
459424008645	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
459424008646	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
459424008647	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
459424008648	putative substrate binding site [chemical binding]; other site
459424008649	putative ATP binding site [chemical binding]; other site
459424008650	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
459424008651	active site
459424008652	Erythromycin esterase; Region: Erythro_esteras; pfam05139
459424008653	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
459424008654	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
459424008655	putative dimer interface [polypeptide binding]; other site
459424008656	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424008657	dimer interface [polypeptide binding]; other site
459424008658	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424008659	acetyl-CoA synthetase; Provisional; Region: PRK04319
459424008660	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
459424008661	active site
459424008662	acyl-activating enzyme (AAE) consensus motif; other site
459424008663	putative CoA binding site [chemical binding]; other site
459424008664	AMP binding site [chemical binding]; other site
459424008665	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
459424008666	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
459424008667	tetramer interface [polypeptide binding]; other site
459424008668	TPP-binding site [chemical binding]; other site
459424008669	heterodimer interface [polypeptide binding]; other site
459424008670	phosphorylation loop region [posttranslational modification]
459424008671	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
459424008672	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
459424008673	alpha subunit interface [polypeptide binding]; other site
459424008674	TPP binding site [chemical binding]; other site
459424008675	heterodimer interface [polypeptide binding]; other site
459424008676	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
459424008677	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
459424008678	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
459424008679	E3 interaction surface; other site
459424008680	lipoyl attachment site [posttranslational modification]; other site
459424008681	e3 binding domain; Region: E3_binding; pfam02817
459424008682	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
459424008683	Phosphopantetheine attachment site; Region: PP-binding; cl09936
459424008684	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
459424008685	PE family; Region: PE; pfam00934
459424008686	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
459424008687	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
459424008688	nickel binding site [ion binding]; other site
459424008689	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
459424008690	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
459424008691	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
459424008692	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
459424008693	FAD binding pocket [chemical binding]; other site
459424008694	FAD binding motif [chemical binding]; other site
459424008695	phosphate binding motif [ion binding]; other site
459424008696	beta-alpha-beta structure motif; other site
459424008697	NAD binding pocket [chemical binding]; other site
459424008698	Iron coordination center [ion binding]; other site
459424008699	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
459424008700	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424008701	dimer interface [polypeptide binding]; other site
459424008702	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
459424008703	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
459424008704	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424008705	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
459424008706	dimer interface [polypeptide binding]; other site
459424008707	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424008708	ligand binding site [chemical binding]; other site
459424008709	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424008710	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424008711	cyclase homology domain; Region: CHD; cd07302
459424008712	nucleotidyl binding site; other site
459424008713	metal binding site [ion binding]; metal-binding site
459424008714	dimer interface [polypeptide binding]; other site
459424008715	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
459424008716	Transcriptional regulator [Transcription]; Region: IclR; COG1414
459424008717	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
459424008718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424008719	NAD(P) binding site [chemical binding]; other site
459424008720	active site
459424008721	enoyl-CoA hydratase; Provisional; Region: PRK09245
459424008722	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424008723	substrate binding site [chemical binding]; other site
459424008724	oxyanion hole (OAH) forming residues; other site
459424008725	trimer interface [polypeptide binding]; other site
459424008726	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424008727	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
459424008728	active site
459424008729	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424008730	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424008731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424008732	NAD(P) binding site [chemical binding]; other site
459424008733	active site
459424008734	short chain dehydrogenase; Provisional; Region: PRK06482
459424008735	classical (c) SDRs; Region: SDR_c; cd05233
459424008736	NAD(P) binding site [chemical binding]; other site
459424008737	active site
459424008738	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
459424008739	Fatty acid desaturase; Region: FA_desaturase; pfam00487
459424008740	Di-iron ligands [ion binding]; other site
459424008741	Rubredoxin [Energy production and conversion]; Region: COG1773
459424008742	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
459424008743	iron binding site [ion binding]; other site
459424008744	Rubredoxin [Energy production and conversion]; Region: COG1773
459424008745	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
459424008746	iron binding site [ion binding]; other site
459424008747	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424008748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424008749	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
459424008750	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
459424008751	active site
459424008752	catalytic tetrad [active]
459424008753	heat shock protein 90; Provisional; Region: PRK05218
459424008754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424008755	ATP binding site [chemical binding]; other site
459424008756	Mg2+ binding site [ion binding]; other site
459424008757	G-X-G motif; other site
459424008758	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008759	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008760	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008761	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
459424008762	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
459424008763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424008764	putative substrate translocation pore; other site
459424008765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424008766	S-adenosylmethionine binding site [chemical binding]; other site
459424008767	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
459424008768	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424008769	Uncharacterized conserved protein [Function unknown]; Region: COG1359
459424008770	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
459424008771	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
459424008772	NAD(P) binding site [chemical binding]; other site
459424008773	glycerol-3-phosphate dehydrogenase; Region: PLN02464
459424008774	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
459424008775	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
459424008776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424008777	S-adenosylmethionine binding site [chemical binding]; other site
459424008778	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424008779	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424008780	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
459424008781	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
459424008782	active site
459424008783	NTP binding site [chemical binding]; other site
459424008784	nucleic acid binding site [nucleotide binding]; other site
459424008785	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008786	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008787	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008788	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
459424008789	CAS motifs; other site
459424008790	active site
459424008791	Uncharacterized conserved protein [Function unknown]; Region: COG0398
459424008792	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
459424008793	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
459424008794	Mechanosensitive ion channel; Region: MS_channel; pfam00924
459424008795	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
459424008796	DNA binding residues [nucleotide binding]
459424008797	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
459424008798	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
459424008799	DNA binding site [nucleotide binding]
459424008800	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424008801	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424008802	phosphopeptide binding site; other site
459424008803	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008804	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008805	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008806	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
459424008807	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
459424008808	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
459424008809	PE family; Region: PE; pfam00934
459424008810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
459424008811	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
459424008812	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
459424008813	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
459424008814	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008815	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008816	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008817	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
459424008818	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
459424008819	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
459424008820	NAD(P) binding site [chemical binding]; other site
459424008821	catalytic residues [active]
459424008822	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
459424008823	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
459424008824	AsnC family; Region: AsnC_trans_reg; pfam01037
459424008825	hypothetical protein; Provisional; Region: PRK06541
459424008826	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424008827	inhibitor-cofactor binding pocket; inhibition site
459424008828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424008829	catalytic residue [active]
459424008830	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424008831	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424008832	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424008833	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424008834	short chain dehydrogenase; Provisional; Region: PRK06179
459424008835	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
459424008836	NADP binding site [chemical binding]; other site
459424008837	active site
459424008838	steroid binding site; other site
459424008839	Domain of unknown function (DUF385); Region: DUF385; cl04387
459424008840	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
459424008841	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
459424008842	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
459424008843	NADP binding site [chemical binding]; other site
459424008844	dimer interface [polypeptide binding]; other site
459424008845	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
459424008846	Amidase; Region: Amidase; pfam01425
459424008847	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
459424008848	Phosphoesterase family; Region: Phosphoesterase; pfam04185
459424008849	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008850	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424008851	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008852	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008853	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008854	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
459424008855	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
459424008856	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
459424008857	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
459424008858	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008859	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
459424008860	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008861	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
459424008862	PE family; Region: PE; pfam00934
459424008863	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008864	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008865	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008866	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
459424008867	SnoaL-like domain; Region: SnoaL_3; pfam13474
459424008868	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
459424008869	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
459424008870	DNA binding site [nucleotide binding]
459424008871	active site
459424008872	Int/Topo IB signature motif; other site
459424008873	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
459424008874	putative dimer interface [polypeptide binding]; other site
459424008875	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424008876	ligand binding site [chemical binding]; other site
459424008877	Zn binding site [ion binding]; other site
459424008878	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
459424008879	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
459424008880	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424008881	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
459424008882	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424008883	motif II; other site
459424008884	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
459424008885	Uncharacterized conserved protein [Function unknown]; Region: COG2128
459424008886	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
459424008887	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
459424008888	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
459424008889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424008890	dimer interface [polypeptide binding]; other site
459424008891	conserved gate region; other site
459424008892	putative PBP binding loops; other site
459424008893	ABC-ATPase subunit interface; other site
459424008894	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
459424008895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424008896	dimer interface [polypeptide binding]; other site
459424008897	conserved gate region; other site
459424008898	putative PBP binding loops; other site
459424008899	ABC-ATPase subunit interface; other site
459424008900	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
459424008901	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
459424008902	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424008903	Ligand Binding Site [chemical binding]; other site
459424008904	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424008905	Ligand Binding Site [chemical binding]; other site
459424008906	amino acid transporter; Region: 2A0306; TIGR00909
459424008907	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
459424008908	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
459424008909	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
459424008910	inhibitor-cofactor binding pocket; inhibition site
459424008911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424008912	catalytic residue [active]
459424008913	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
459424008914	Amidinotransferase; Region: Amidinotransf; pfam02274
459424008915	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
459424008916	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
459424008917	putative DNA binding site [nucleotide binding]; other site
459424008918	putative Zn2+ binding site [ion binding]; other site
459424008919	AsnC family; Region: AsnC_trans_reg; pfam01037
459424008920	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
459424008921	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644
459424008922	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
459424008923	Walker A/P-loop; other site
459424008924	ATP binding site [chemical binding]; other site
459424008925	Q-loop/lid; other site
459424008926	ABC transporter signature motif; other site
459424008927	Walker B; other site
459424008928	D-loop; other site
459424008929	H-loop/switch region; other site
459424008930	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
459424008931	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
459424008932	Walker A/P-loop; other site
459424008933	ATP binding site [chemical binding]; other site
459424008934	Q-loop/lid; other site
459424008935	ABC transporter signature motif; other site
459424008936	Walker B; other site
459424008937	D-loop; other site
459424008938	H-loop/switch region; other site
459424008939	Transcriptional regulators [Transcription]; Region: MarR; COG1846
459424008940	MarR family; Region: MarR; pfam01047
459424008941	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424008942	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
459424008943	Walker A/P-loop; other site
459424008944	ATP binding site [chemical binding]; other site
459424008945	Q-loop/lid; other site
459424008946	ABC transporter signature motif; other site
459424008947	Walker B; other site
459424008948	D-loop; other site
459424008949	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
459424008950	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
459424008951	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
459424008952	Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135
459424008953	CCC1-related family of proteins; Region: CCC1_like; cl00278
459424008954	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424008955	acyl-coenzyme A oxidase; Region: PLN02636
459424008956	active site
459424008957	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008958	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008959	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008960	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
459424008961	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
459424008962	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
459424008963	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008964	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424008965	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424008966	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424008967	dimerization interface [polypeptide binding]; other site
459424008968	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424008969	cyclase homology domain; Region: CHD; cd07302
459424008970	nucleotidyl binding site; other site
459424008971	metal binding site [ion binding]; metal-binding site
459424008972	dimer interface [polypeptide binding]; other site
459424008973	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
459424008974	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
459424008975	[4Fe-4S] binding site [ion binding]; other site
459424008976	molybdopterin cofactor binding site; other site
459424008977	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
459424008978	molybdopterin cofactor binding site; other site
459424008979	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
459424008980	Flavodoxin; Region: Flavodoxin_1; pfam00258
459424008981	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
459424008982	FAD binding pocket [chemical binding]; other site
459424008983	FAD binding motif [chemical binding]; other site
459424008984	catalytic residues [active]
459424008985	NAD binding pocket [chemical binding]; other site
459424008986	phosphate binding motif [ion binding]; other site
459424008987	beta-alpha-beta structure motif; other site
459424008988	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
459424008989	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
459424008990	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424008991	NADP-dependent malic enzyme; Provisional; Region: PTZ00317
459424008992	Malic enzyme, N-terminal domain; Region: malic; pfam00390
459424008993	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
459424008994	NAD(P) binding pocket [chemical binding]; other site
459424008995	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
459424008996	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
459424008997	dimer interface [polypeptide binding]; other site
459424008998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424008999	catalytic residue [active]
459424009000	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
459424009001	trimer interface [polypeptide binding]; other site
459424009002	active site
459424009003	substrate binding site [chemical binding]; other site
459424009004	CoA binding site [chemical binding]; other site
459424009005	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
459424009006	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
459424009007	catalytic residues [active]
459424009008	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
459424009009	DNA primase; Validated; Region: dnaG; PRK05667
459424009010	CHC2 zinc finger; Region: zf-CHC2; cl17510
459424009011	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
459424009012	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
459424009013	active site
459424009014	metal binding site [ion binding]; metal-binding site
459424009015	interdomain interaction site; other site
459424009016	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
459424009017	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
459424009018	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
459424009019	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
459424009020	Zn2+ binding site [ion binding]; other site
459424009021	Mg2+ binding site [ion binding]; other site
459424009022	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
459424009023	Repair protein; Region: Repair_PSII; pfam04536
459424009024	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
459424009025	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
459424009026	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009027	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009028	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009029	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
459424009030	Phosphoesterase family; Region: Phosphoesterase; pfam04185
459424009031	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009032	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009033	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009034	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424009035	PPE family; Region: PPE; pfam00823
459424009036	Transposase, Mutator family; Region: Transposase_mut; pfam00872
459424009037	MULE transposase domain; Region: MULE; pfam10551
459424009038	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009039	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009040	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009042	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009043	glycyl-tRNA synthetase; Provisional; Region: PRK04173
459424009044	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
459424009045	motif 1; other site
459424009046	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
459424009047	active site
459424009048	motif 2; other site
459424009049	motif 3; other site
459424009050	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
459424009051	anticodon binding site; other site
459424009052	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424009053	dimerization interface [polypeptide binding]; other site
459424009054	putative DNA binding site [nucleotide binding]; other site
459424009055	putative Zn2+ binding site [ion binding]; other site
459424009056	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
459424009057	metal binding site 2 [ion binding]; metal-binding site
459424009058	putative DNA binding helix; other site
459424009059	metal binding site 1 [ion binding]; metal-binding site
459424009060	dimer interface [polypeptide binding]; other site
459424009061	structural Zn2+ binding site [ion binding]; other site
459424009062	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
459424009063	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
459424009064	catalytic residue [active]
459424009065	putative FPP diphosphate  binding site; other site
459424009066	putative FPP binding hydrophobic cleft; other site
459424009067	dimer interface [polypeptide binding]; other site
459424009068	putative IPP diphosphate binding site; other site
459424009069	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
459424009070	Recombination protein O N terminal; Region: RecO_N; pfam11967
459424009071	Recombination protein O C terminal; Region: RecO_C; pfam02565
459424009072	amidase; Provisional; Region: PRK06061
459424009073	Amidase; Region: Amidase; pfam01425
459424009074	GTPase Era; Reviewed; Region: era; PRK00089
459424009075	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
459424009076	G1 box; other site
459424009077	GTP/Mg2+ binding site [chemical binding]; other site
459424009078	Switch I region; other site
459424009079	G2 box; other site
459424009080	Switch II region; other site
459424009081	G3 box; other site
459424009082	G4 box; other site
459424009083	G5 box; other site
459424009084	KH domain; Region: KH_2; pfam07650
459424009085	Domain of unknown function DUF21; Region: DUF21; pfam01595
459424009086	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
459424009087	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
459424009088	Transporter associated domain; Region: CorC_HlyC; smart01091
459424009089	metal-binding heat shock protein; Provisional; Region: PRK00016
459424009090	K homology RNA-binding domain; Region: KH; smart00322
459424009091	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
459424009092	PhoH-like protein; Region: PhoH; pfam02562
459424009093	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424009094	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
459424009095	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424009096	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424009097	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424009098	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
459424009099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
459424009100	RNA methyltransferase, RsmE family; Region: TIGR00046
459424009101	chaperone protein DnaJ; Provisional; Region: PRK14278
459424009102	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
459424009103	HSP70 interaction site [polypeptide binding]; other site
459424009104	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
459424009105	Zn binding sites [ion binding]; other site
459424009106	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
459424009107	dimer interface [polypeptide binding]; other site
459424009108	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
459424009109	HTH domain; Region: HTH_11; cl17392
459424009110	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
459424009111	Uncharacterized conserved protein [Function unknown]; Region: COG2128
459424009112	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
459424009113	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
459424009114	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424009115	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009116	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009117	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009118	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
459424009119	Condensation domain; Region: Condensation; pfam00668
459424009120	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
459424009121	Nonribosomal peptide synthase; Region: NRPS; pfam08415
459424009122	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
459424009123	acyl-activating enzyme (AAE) consensus motif; other site
459424009124	AMP binding site [chemical binding]; other site
459424009125	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424009126	Condensation domain; Region: Condensation; pfam00668
459424009127	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
459424009128	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
459424009129	acyl-activating enzyme (AAE) consensus motif; other site
459424009130	AMP binding site [chemical binding]; other site
459424009131	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424009132	Condensation domain; Region: Condensation; pfam00668
459424009133	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
459424009134	Condensation domain; Region: Condensation; pfam00668
459424009135	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
459424009136	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
459424009137	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
459424009138	acyl-activating enzyme (AAE) consensus motif; other site
459424009139	AMP binding site [chemical binding]; other site
459424009140	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424009141	Condensation domain; Region: Condensation; pfam00668
459424009142	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
459424009143	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
459424009144	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424009145	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
459424009146	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
459424009147	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
459424009148	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424009149	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
459424009150	active site
459424009151	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424009152	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424009153	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
459424009154	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
459424009155	NADP binding site [chemical binding]; other site
459424009156	active site
459424009157	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424009158	MbtH-like protein; Region: MbtH; pfam03621
459424009159	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
459424009160	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
459424009161	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
459424009162	acyl-activating enzyme (AAE) consensus motif; other site
459424009163	active site
459424009164	AMP binding site [chemical binding]; other site
459424009165	substrate binding site [chemical binding]; other site
459424009166	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
459424009167	short chain dehydrogenase; Provisional; Region: PRK07832
459424009168	classical (c) SDRs; Region: SDR_c; cd05233
459424009169	NAD(P) binding site [chemical binding]; other site
459424009170	active site
459424009171	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
459424009172	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
459424009173	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
459424009174	DNA binding residues [nucleotide binding]
459424009175	putative dimer interface [polypeptide binding]; other site
459424009176	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
459424009177	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
459424009178	homodimer interface [polypeptide binding]; other site
459424009179	putative substrate binding pocket [chemical binding]; other site
459424009180	diiron center [ion binding]; other site
459424009181	salicylate synthase MbtI; Reviewed; Region: PRK07912
459424009182	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
459424009183	Predicted permease [General function prediction only]; Region: COG3329
459424009184	coproporphyrinogen III oxidase; Validated; Region: PRK05628
459424009185	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
459424009186	active site
459424009187	HemN C-terminal domain; Region: HemN_C; pfam06969
459424009188	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
459424009189	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
459424009190	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
459424009191	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
459424009192	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
459424009193	Active Sites [active]
459424009194	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
459424009195	putative active site [active]
459424009196	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
459424009197	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
459424009198	Predicted membrane protein [Function unknown]; Region: COG1297
459424009199	putative oligopeptide transporter, OPT family; Region: TIGR00733
459424009200	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
459424009201	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
459424009202	Walker A/P-loop; other site
459424009203	ATP binding site [chemical binding]; other site
459424009204	Q-loop/lid; other site
459424009205	ABC transporter signature motif; other site
459424009206	Walker B; other site
459424009207	D-loop; other site
459424009208	H-loop/switch region; other site
459424009209	TOBE domain; Region: TOBE; pfam03459
459424009210	sulfate transport protein; Provisional; Region: cysT; CHL00187
459424009211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424009212	dimer interface [polypeptide binding]; other site
459424009213	conserved gate region; other site
459424009214	putative PBP binding loops; other site
459424009215	ABC-ATPase subunit interface; other site
459424009216	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
459424009217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424009218	dimer interface [polypeptide binding]; other site
459424009219	conserved gate region; other site
459424009220	putative PBP binding loops; other site
459424009221	ABC-ATPase subunit interface; other site
459424009222	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
459424009223	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
459424009224	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
459424009225	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
459424009226	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424009227	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424009228	GTP-binding protein LepA; Provisional; Region: PRK05433
459424009229	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
459424009230	G1 box; other site
459424009231	putative GEF interaction site [polypeptide binding]; other site
459424009232	GTP/Mg2+ binding site [chemical binding]; other site
459424009233	Switch I region; other site
459424009234	G2 box; other site
459424009235	G3 box; other site
459424009236	Switch II region; other site
459424009237	G4 box; other site
459424009238	G5 box; other site
459424009239	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
459424009240	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
459424009241	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
459424009242	PemK-like protein; Region: PemK; pfam02452
459424009243	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
459424009244	FOG: CBS domain [General function prediction only]; Region: COG0517
459424009245	ribonuclease Z; Reviewed; Region: PRK00055
459424009246	PE family; Region: PE; pfam00934
459424009247	PE family; Region: PE; pfam00934
459424009248	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
459424009249	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
459424009250	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
459424009251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
459424009252	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
459424009253	Uncharacterized conserved protein [Function unknown]; Region: COG2308
459424009254	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
459424009255	hypothetical protein; Reviewed; Region: PRK07914
459424009256	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
459424009257	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
459424009258	Competence protein; Region: Competence; cl00471
459424009259	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
459424009260	Helix-hairpin-helix motif; Region: HHH; pfam00633
459424009261	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
459424009262	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009263	active site
459424009264	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
459424009265	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424009266	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
459424009267	active site
459424009268	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424009269	hypothetical protein; Provisional; Region: PRK01346
459424009270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424009271	Coenzyme A binding pocket [chemical binding]; other site
459424009272	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
459424009273	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
459424009274	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
459424009275	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
459424009276	EDD domain protein, DegV family; Region: DegV; TIGR00762
459424009277	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
459424009278	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
459424009279	active site
459424009280	catalytic triad [active]
459424009281	oxyanion hole [active]
459424009282	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424009283	catalytic core [active]
459424009284	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
459424009285	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
459424009286	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
459424009287	active site
459424009288	(T/H)XGH motif; other site
459424009289	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424009290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424009291	S-adenosylmethionine binding site [chemical binding]; other site
459424009292	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
459424009293	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
459424009294	metal ion-dependent adhesion site (MIDAS); other site
459424009295	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
459424009296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424009297	Walker A motif; other site
459424009298	ATP binding site [chemical binding]; other site
459424009299	Walker B motif; other site
459424009300	arginine finger; other site
459424009301	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
459424009302	putative catalytic cysteine [active]
459424009303	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
459424009304	Mechanosensitive ion channel; Region: MS_channel; pfam00924
459424009305	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424009306	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424009307	ligand binding site [chemical binding]; other site
459424009308	flexible hinge region; other site
459424009309	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424009310	dimerization interface [polypeptide binding]; other site
459424009311	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
459424009312	cyclase homology domain; Region: CHD; cd07302
459424009313	nucleotidyl binding site; other site
459424009314	metal binding site [ion binding]; metal-binding site
459424009315	dimer interface [polypeptide binding]; other site
459424009316	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
459424009317	Mechanosensitive ion channel; Region: MS_channel; pfam00924
459424009318	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424009319	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424009320	ligand binding site [chemical binding]; other site
459424009321	flexible hinge region; other site
459424009322	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009323	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009324	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009325	PE family; Region: PE; pfam00934
459424009326	NAD synthetase; Reviewed; Region: nadE; PRK02628
459424009327	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
459424009328	multimer interface [polypeptide binding]; other site
459424009329	active site
459424009330	catalytic triad [active]
459424009331	protein interface 1 [polypeptide binding]; other site
459424009332	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
459424009333	homodimer interface [polypeptide binding]; other site
459424009334	NAD binding pocket [chemical binding]; other site
459424009335	ATP binding pocket [chemical binding]; other site
459424009336	Mg binding site [ion binding]; other site
459424009337	active-site loop [active]
459424009338	NAD-dependent deacetylase; Provisional; Region: PRK05333
459424009339	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
459424009340	NAD+ binding site [chemical binding]; other site
459424009341	substrate binding site [chemical binding]; other site
459424009342	Zn binding site [ion binding]; other site
459424009343	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424009344	Cytochrome P450; Region: p450; cl12078
459424009345	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424009346	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424009347	gamma-glutamyl kinase; Provisional; Region: PRK05429
459424009348	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
459424009349	nucleotide binding site [chemical binding]; other site
459424009350	homotetrameric interface [polypeptide binding]; other site
459424009351	putative phosphate binding site [ion binding]; other site
459424009352	putative allosteric binding site; other site
459424009353	PUA domain; Region: PUA; pfam01472
459424009354	GTPase CgtA; Reviewed; Region: obgE; PRK12296
459424009355	GTP1/OBG; Region: GTP1_OBG; pfam01018
459424009356	Obg GTPase; Region: Obg; cd01898
459424009357	G1 box; other site
459424009358	GTP/Mg2+ binding site [chemical binding]; other site
459424009359	Switch I region; other site
459424009360	G2 box; other site
459424009361	G3 box; other site
459424009362	Switch II region; other site
459424009363	G4 box; other site
459424009364	G5 box; other site
459424009365	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
459424009366	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
459424009367	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
459424009368	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
459424009369	active site
459424009370	multimer interface [polypeptide binding]; other site
459424009371	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
459424009372	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
459424009373	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
459424009374	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
459424009375	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
459424009376	active site
459424009377	HIGH motif; other site
459424009378	nucleotide binding site [chemical binding]; other site
459424009379	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
459424009380	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
459424009381	active site
459424009382	KMSKS motif; other site
459424009383	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
459424009384	tRNA binding surface [nucleotide binding]; other site
459424009385	anticodon binding site; other site
459424009386	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
459424009387	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
459424009388	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
459424009389	dimerization interface [polypeptide binding]; other site
459424009390	mannose binding site [chemical binding]; other site
459424009391	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
459424009392	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
459424009393	Uncharacterized conserved protein [Function unknown]; Region: COG3268
459424009394	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
459424009395	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009396	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009397	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009398	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009399	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009400	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009401	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
459424009402	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
459424009403	GTP binding site; other site
459424009404	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
459424009405	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
459424009406	TPP-binding site [chemical binding]; other site
459424009407	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
459424009408	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
459424009409	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
459424009410	dimer interface [polypeptide binding]; other site
459424009411	PYR/PP interface [polypeptide binding]; other site
459424009412	TPP binding site [chemical binding]; other site
459424009413	substrate binding site [chemical binding]; other site
459424009414	Major Facilitator Superfamily; Region: MFS_1; pfam07690
459424009415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424009416	putative substrate translocation pore; other site
459424009417	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
459424009418	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
459424009419	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424009420	Walker A motif; other site
459424009421	ATP binding site [chemical binding]; other site
459424009422	Walker B motif; other site
459424009423	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
459424009424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424009425	putative substrate translocation pore; other site
459424009426	Major Facilitator Superfamily; Region: MFS_1; pfam07690
459424009427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424009428	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
459424009429	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
459424009430	oligomer interface [polypeptide binding]; other site
459424009431	active site residues [active]
459424009432	Clp protease; Region: CLP_protease; pfam00574
459424009433	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
459424009434	oligomer interface [polypeptide binding]; other site
459424009435	active site residues [active]
459424009436	trigger factor; Provisional; Region: tig; PRK01490
459424009437	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
459424009438	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
459424009439	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424009440	Beta-lactamase; Region: Beta-lactamase; pfam00144
459424009441	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
459424009442	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
459424009443	putative DNA binding site [nucleotide binding]; other site
459424009444	catalytic residue [active]
459424009445	putative H2TH interface [polypeptide binding]; other site
459424009446	putative catalytic residues [active]
459424009447	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
459424009448	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
459424009449	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
459424009450	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
459424009451	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
459424009452	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
459424009453	catalytic residues [active]
459424009454	PE family; Region: PE; pfam00934
459424009455	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
459424009456	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
459424009457	Zn binding site [ion binding]; other site
459424009458	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
459424009459	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424009460	active site
459424009461	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
459424009462	apolar tunnel; other site
459424009463	heme binding site [chemical binding]; other site
459424009464	dimerization interface [polypeptide binding]; other site
459424009465	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
459424009466	Phosphoesterase family; Region: Phosphoesterase; pfam04185
459424009467	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
459424009468	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
459424009469	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424009470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424009471	putative substrate translocation pore; other site
459424009472	hypothetical protein; Provisional; Region: PRK07877
459424009473	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
459424009474	ATP binding site [chemical binding]; other site
459424009475	substrate interface [chemical binding]; other site
459424009476	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009477	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009478	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009479	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009480	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009481	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009482	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
459424009483	active site
459424009484	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
459424009485	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
459424009486	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
459424009487	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
459424009488	ABC transporter; Region: ABC_tran_2; pfam12848
459424009489	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
459424009490	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
459424009491	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
459424009492	dimer interface [polypeptide binding]; other site
459424009493	ssDNA binding site [nucleotide binding]; other site
459424009494	tetramer (dimer of dimers) interface [polypeptide binding]; other site
459424009495	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
459424009496	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
459424009497	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
459424009498	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
459424009499	putative acyl-acceptor binding pocket; other site
459424009500	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
459424009501	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
459424009502	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424009503	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
459424009504	putative acyl-acceptor binding pocket; other site
459424009505	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424009506	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424009507	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424009508	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
459424009509	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424009510	Cutinase; Region: Cutinase; pfam01083
459424009511	cobyric acid synthase; Provisional; Region: PRK00784
459424009512	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
459424009513	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
459424009514	catalytic triad [active]
459424009515	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009516	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009517	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009518	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009519	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009520	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009521	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424009522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
459424009523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424009524	S-adenosylmethionine binding site [chemical binding]; other site
459424009525	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
459424009526	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
459424009527	E3 interaction surface; other site
459424009528	lipoyl attachment site [posttranslational modification]; other site
459424009529	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
459424009530	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
459424009531	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
459424009532	alpha subunit interface [polypeptide binding]; other site
459424009533	TPP binding site [chemical binding]; other site
459424009534	heterodimer interface [polypeptide binding]; other site
459424009535	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
459424009536	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
459424009537	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
459424009538	tetramer interface [polypeptide binding]; other site
459424009539	TPP-binding site [chemical binding]; other site
459424009540	heterodimer interface [polypeptide binding]; other site
459424009541	phosphorylation loop region [posttranslational modification]
459424009542	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
459424009543	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
459424009544	putative active site [active]
459424009545	putative catalytic site [active]
459424009546	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424009547	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009548	active site
459424009549	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
459424009550	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
459424009551	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
459424009552	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
459424009553	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
459424009554	carboxyltransferase (CT) interaction site; other site
459424009555	biotinylation site [posttranslational modification]; other site
459424009556	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
459424009557	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
459424009558	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
459424009559	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
459424009560	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
459424009561	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009562	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009563	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009564	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424009565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424009566	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
459424009567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424009568	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
459424009569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424009570	NAD(P) binding site [chemical binding]; other site
459424009571	active site
459424009572	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
459424009573	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
459424009574	catalytic site [active]
459424009575	putative active site [active]
459424009576	putative substrate binding site [chemical binding]; other site
459424009577	dimer interface [polypeptide binding]; other site
459424009578	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
459424009579	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424009580	Permease; Region: Permease; pfam02405
459424009581	Permease; Region: Permease; pfam02405
459424009582	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
459424009583	mce related protein; Region: MCE; pfam02470
459424009584	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424009585	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009586	mce related protein; Region: MCE; pfam02470
459424009587	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009588	mce related protein; Region: MCE; pfam02470
459424009589	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009590	mce related protein; Region: MCE; pfam02470
459424009591	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009592	mce related protein; Region: MCE; pfam02470
459424009593	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009594	mce related protein; Region: MCE; pfam02470
459424009595	Mannan-binding protein; Region: MVL; pfam12151
459424009596	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
459424009597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
459424009598	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
459424009599	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
459424009600	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
459424009601	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424009602	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424009603	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
459424009604	putative acyl-acceptor binding pocket; other site
459424009605	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
459424009606	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
459424009607	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
459424009608	catalytic triad [active]
459424009609	hypothetical protein; Provisional; Region: PRK07907
459424009610	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
459424009611	active site
459424009612	metal binding site [ion binding]; metal-binding site
459424009613	dimer interface [polypeptide binding]; other site
459424009614	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009615	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009616	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009617	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
459424009618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424009619	ATP binding site [chemical binding]; other site
459424009620	Mg2+ binding site [ion binding]; other site
459424009621	G-X-G motif; other site
459424009622	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
459424009623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424009624	active site
459424009625	phosphorylation site [posttranslational modification]
459424009626	intermolecular recognition site; other site
459424009627	dimerization interface [polypeptide binding]; other site
459424009628	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
459424009629	DNA binding residues [nucleotide binding]
459424009630	dimerization interface [polypeptide binding]; other site
459424009631	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
459424009632	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
459424009633	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
459424009634	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
459424009635	phosphate binding site [ion binding]; other site
459424009636	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
459424009637	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
459424009638	putative active site [active]
459424009639	putative catalytic site [active]
459424009640	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
459424009641	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424009642	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
459424009643	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
459424009644	putative NAD(P) binding site [chemical binding]; other site
459424009645	active site
459424009646	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
459424009647	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
459424009648	active site
459424009649	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
459424009650	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
459424009651	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
459424009652	[2Fe-2S] cluster binding site [ion binding]; other site
459424009653	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
459424009654	putative alpha subunit interface [polypeptide binding]; other site
459424009655	putative active site [active]
459424009656	putative substrate binding site [chemical binding]; other site
459424009657	Fe binding site [ion binding]; other site
459424009658	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
459424009659	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
459424009660	NAD binding site [chemical binding]; other site
459424009661	catalytic residues [active]
459424009662	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
459424009663	putative active site [active]
459424009664	putative catalytic site [active]
459424009665	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424009666	active site 2 [active]
459424009667	active site 1 [active]
459424009668	SnoaL-like domain; Region: SnoaL_4; pfam13577
459424009669	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009670	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009671	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424009672	Cytochrome P450; Region: p450; cl12078
459424009673	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
459424009674	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
459424009675	[2Fe-2S] cluster binding site [ion binding]; other site
459424009676	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
459424009677	hydrophobic ligand binding site; other site
459424009678	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
459424009679	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
459424009680	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424009681	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424009682	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424009683	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424009684	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424009685	Cytochrome P450; Region: p450; cl12078
459424009686	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009687	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009688	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009689	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424009690	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009691	active site
459424009692	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009693	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424009694	active site
459424009695	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009696	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
459424009697	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424009698	acyl-activating enzyme (AAE) consensus motif; other site
459424009699	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
459424009700	putative AMP binding site [chemical binding]; other site
459424009701	putative active site [active]
459424009702	acyl-activating enzyme (AAE) consensus motif; other site
459424009703	putative CoA binding site [chemical binding]; other site
459424009704	PE family; Region: PE; pfam00934
459424009705	PE-PPE domain; Region: PE-PPE; pfam08237
459424009706	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
459424009707	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
459424009708	putative sugar binding sites [chemical binding]; other site
459424009709	Q-X-W motif; other site
459424009710	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424009711	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424009712	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
459424009713	CoenzymeA binding site [chemical binding]; other site
459424009714	subunit interaction site [polypeptide binding]; other site
459424009715	PHB binding site; other site
459424009716	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424009717	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424009718	PPE family; Region: PPE; pfam00823
459424009719	PAS fold; Region: PAS_4; pfam08448
459424009720	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
459424009721	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
459424009722	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
459424009723	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
459424009724	anti sigma factor interaction site; other site
459424009725	regulatory phosphorylation site [posttranslational modification]; other site
459424009726	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424009727	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
459424009728	acyl-activating enzyme (AAE) consensus motif; other site
459424009729	acyl-activating enzyme (AAE) consensus motif; other site
459424009730	putative AMP binding site [chemical binding]; other site
459424009731	putative active site [active]
459424009732	putative CoA binding site [chemical binding]; other site
459424009733	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424009734	Cytochrome P450; Region: p450; cl12078
459424009735	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424009736	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424009737	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424009738	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009739	active site
459424009740	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
459424009741	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424009742	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009743	active site
459424009744	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424009745	acyl-CoA synthetase; Validated; Region: PRK07798
459424009746	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424009747	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
459424009748	acyl-activating enzyme (AAE) consensus motif; other site
459424009749	acyl-activating enzyme (AAE) consensus motif; other site
459424009750	putative AMP binding site [chemical binding]; other site
459424009751	putative active site [active]
459424009752	putative CoA binding site [chemical binding]; other site
459424009753	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424009754	enoyl-CoA hydratase; Provisional; Region: PRK06210
459424009755	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424009756	substrate binding site [chemical binding]; other site
459424009757	oxyanion hole (OAH) forming residues; other site
459424009758	trimer interface [polypeptide binding]; other site
459424009759	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
459424009760	tetracycline repressor protein TetR; Provisional; Region: PRK13756
459424009761	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424009762	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
459424009763	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424009764	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424009765	substrate binding site [chemical binding]; other site
459424009766	oxyanion hole (OAH) forming residues; other site
459424009767	trimer interface [polypeptide binding]; other site
459424009768	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424009769	enoyl-CoA hydratase; Provisional; Region: PRK06688
459424009770	substrate binding site [chemical binding]; other site
459424009771	oxyanion hole (OAH) forming residues; other site
459424009772	trimer interface [polypeptide binding]; other site
459424009773	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424009774	enoyl-CoA hydratase; Provisional; Region: PRK06494
459424009775	substrate binding site [chemical binding]; other site
459424009776	oxyanion hole (OAH) forming residues; other site
459424009777	trimer interface [polypeptide binding]; other site
459424009778	enoyl-CoA hydratase; Provisional; Region: PRK05980
459424009779	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424009780	substrate binding site [chemical binding]; other site
459424009781	oxyanion hole (OAH) forming residues; other site
459424009782	trimer interface [polypeptide binding]; other site
459424009783	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424009784	AMP-binding enzyme; Region: AMP-binding; pfam00501
459424009785	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424009786	acyl-activating enzyme (AAE) consensus motif; other site
459424009787	acyl-activating enzyme (AAE) consensus motif; other site
459424009788	AMP binding site [chemical binding]; other site
459424009789	active site
459424009790	CoA binding site [chemical binding]; other site
459424009791	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
459424009792	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424009793	acyl-activating enzyme (AAE) consensus motif; other site
459424009794	AMP binding site [chemical binding]; other site
459424009795	active site
459424009796	CoA binding site [chemical binding]; other site
459424009797	Transcriptional regulators [Transcription]; Region: GntR; COG1802
459424009798	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424009799	DNA-binding site [nucleotide binding]; DNA binding site
459424009800	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
459424009801	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424009802	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009803	active site
459424009804	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
459424009805	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424009806	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
459424009807	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424009808	dimer interface [polypeptide binding]; other site
459424009809	active site
459424009810	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424009811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424009812	NAD(P) binding site [chemical binding]; other site
459424009813	active site
459424009814	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424009815	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424009816	active site
459424009817	Phosphotransferase enzyme family; Region: APH; pfam01636
459424009818	Ecdysteroid kinase; Region: EcKinase; cl17738
459424009819	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
459424009820	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424009821	Walker A/P-loop; other site
459424009822	ATP binding site [chemical binding]; other site
459424009823	Q-loop/lid; other site
459424009824	ABC transporter signature motif; other site
459424009825	Walker B; other site
459424009826	D-loop; other site
459424009827	H-loop/switch region; other site
459424009828	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
459424009829	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
459424009830	FAD binding pocket [chemical binding]; other site
459424009831	FAD binding motif [chemical binding]; other site
459424009832	phosphate binding motif [ion binding]; other site
459424009833	NAD binding pocket [chemical binding]; other site
459424009834	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
459424009835	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
459424009836	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424009837	Walker A/P-loop; other site
459424009838	ATP binding site [chemical binding]; other site
459424009839	Q-loop/lid; other site
459424009840	ABC transporter signature motif; other site
459424009841	Walker B; other site
459424009842	D-loop; other site
459424009843	H-loop/switch region; other site
459424009844	Glucitol operon activator protein (GutM); Region: GutM; cl01890
459424009845	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
459424009846	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
459424009847	active site
459424009848	dimerization interface [polypeptide binding]; other site
459424009849	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
459424009850	ribonuclease PH; Reviewed; Region: rph; PRK00173
459424009851	Ribonuclease PH; Region: RNase_PH_bact; cd11362
459424009852	hexamer interface [polypeptide binding]; other site
459424009853	active site
459424009854	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
459424009855	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
459424009856	TPP-binding site [chemical binding]; other site
459424009857	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
459424009858	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
459424009859	dimerization interface [polypeptide binding]; other site
459424009860	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
459424009861	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
459424009862	putative DNA binding site [nucleotide binding]; other site
459424009863	putative Zn2+ binding site [ion binding]; other site
459424009864	AsnC family; Region: AsnC_trans_reg; pfam01037
459424009865	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009866	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424009867	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009868	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424009869	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424009870	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009871	mce related protein; Region: MCE; pfam02470
459424009872	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424009873	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009874	mce related protein; Region: MCE; pfam02470
459424009875	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009876	mce related protein; Region: MCE; pfam02470
459424009877	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009878	mce related protein; Region: MCE; pfam02470
459424009879	mce related protein; Region: MCE; pfam02470
459424009880	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424009881	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424009882	mce related protein; Region: MCE; pfam02470
459424009883	glutamate racemase; Provisional; Region: PRK00865
459424009884	Rhomboid family; Region: Rhomboid; pfam01694
459424009885	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
459424009886	MoaE interaction surface [polypeptide binding]; other site
459424009887	MoeB interaction surface [polypeptide binding]; other site
459424009888	thiocarboxylated glycine; other site
459424009889	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
459424009890	MPN+ (JAMM) motif; other site
459424009891	Zinc-binding site [ion binding]; other site
459424009892	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
459424009893	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
459424009894	cleavage site
459424009895	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
459424009896	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
459424009897	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
459424009898	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
459424009899	active site
459424009900	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
459424009901	DEAD/DEAH box helicase; Region: DEAD; pfam00270
459424009902	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
459424009903	putative Mg++ binding site [ion binding]; other site
459424009904	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
459424009905	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
459424009906	putative homodimer interface [polypeptide binding]; other site
459424009907	putative active site pocket [active]
459424009908	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
459424009909	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
459424009910	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
459424009911	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
459424009912	active site
459424009913	homodimer interface [polypeptide binding]; other site
459424009914	catalytic site [active]
459424009915	acceptor binding site [chemical binding]; other site
459424009916	glycogen branching enzyme; Provisional; Region: PRK05402
459424009917	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
459424009918	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
459424009919	active site
459424009920	catalytic site [active]
459424009921	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
459424009922	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
459424009923	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
459424009924	putative acyltransferase; Provisional; Region: PRK05790
459424009925	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424009926	dimer interface [polypeptide binding]; other site
459424009927	active site
459424009928	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424009929	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
459424009930	dimer interface [polypeptide binding]; other site
459424009931	substrate binding site [chemical binding]; other site
459424009932	metal binding site [ion binding]; metal-binding site
459424009933	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
459424009934	hypothetical protein; Provisional; Region: PRK03298
459424009935	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424009936	dimerization interface [polypeptide binding]; other site
459424009937	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424009938	cyclase homology domain; Region: CHD; cd07302
459424009939	nucleotidyl binding site; other site
459424009940	metal binding site [ion binding]; metal-binding site
459424009941	dimer interface [polypeptide binding]; other site
459424009942	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
459424009943	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
459424009944	AlkA N-terminal domain; Region: AlkA_N; pfam06029
459424009945	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
459424009946	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
459424009947	minor groove reading motif; other site
459424009948	helix-hairpin-helix signature motif; other site
459424009949	substrate binding pocket [chemical binding]; other site
459424009950	active site
459424009951	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
459424009952	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
459424009953	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
459424009954	DNA binding site [nucleotide binding]
459424009955	active site
459424009956	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
459424009957	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
459424009958	hinge; other site
459424009959	active site
459424009960	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
459424009961	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
459424009962	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
459424009963	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
459424009964	gamma subunit interface [polypeptide binding]; other site
459424009965	epsilon subunit interface [polypeptide binding]; other site
459424009966	LBP interface [polypeptide binding]; other site
459424009967	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
459424009968	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
459424009969	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
459424009970	alpha subunit interaction interface [polypeptide binding]; other site
459424009971	Walker A motif; other site
459424009972	ATP binding site [chemical binding]; other site
459424009973	Walker B motif; other site
459424009974	inhibitor binding site; inhibition site
459424009975	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
459424009976	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
459424009977	core domain interface [polypeptide binding]; other site
459424009978	delta subunit interface [polypeptide binding]; other site
459424009979	epsilon subunit interface [polypeptide binding]; other site
459424009980	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
459424009981	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
459424009982	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
459424009983	beta subunit interaction interface [polypeptide binding]; other site
459424009984	Walker A motif; other site
459424009985	ATP binding site [chemical binding]; other site
459424009986	Walker B motif; other site
459424009987	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
459424009988	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
459424009989	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
459424009990	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
459424009991	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
459424009992	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
459424009993	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
459424009994	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
459424009995	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
459424009996	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
459424009997	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
459424009998	Mg++ binding site [ion binding]; other site
459424009999	putative catalytic motif [active]
459424010000	substrate binding site [chemical binding]; other site
459424010001	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
459424010002	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
459424010003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424010004	S-adenosylmethionine binding site [chemical binding]; other site
459424010005	peptide chain release factor 1; Validated; Region: prfA; PRK00591
459424010006	This domain is found in peptide chain release factors; Region: PCRF; smart00937
459424010007	RF-1 domain; Region: RF-1; pfam00472
459424010008	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
459424010009	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
459424010010	transcription termination factor Rho; Provisional; Region: PRK12608
459424010011	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
459424010012	RNA binding site [nucleotide binding]; other site
459424010013	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
459424010014	multimer interface [polypeptide binding]; other site
459424010015	Walker A motif; other site
459424010016	ATP binding site [chemical binding]; other site
459424010017	Walker B motif; other site
459424010018	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
459424010019	threonine synthase; Reviewed; Region: PRK06721
459424010020	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
459424010021	homodimer interface [polypeptide binding]; other site
459424010022	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424010023	catalytic residue [active]
459424010024	homoserine dehydrogenase; Provisional; Region: PRK06349
459424010025	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
459424010026	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
459424010027	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
459424010028	diaminopimelate decarboxylase; Region: lysA; TIGR01048
459424010029	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
459424010030	active site
459424010031	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
459424010032	substrate binding site [chemical binding]; other site
459424010033	catalytic residues [active]
459424010034	dimer interface [polypeptide binding]; other site
459424010035	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
459424010036	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
459424010037	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
459424010038	active site
459424010039	HIGH motif; other site
459424010040	KMSK motif region; other site
459424010041	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
459424010042	tRNA binding surface [nucleotide binding]; other site
459424010043	anticodon binding site; other site
459424010044	PE family; Region: PE; pfam00934
459424010045	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
459424010046	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
459424010047	putative catalytic cysteine [active]
459424010048	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
459424010049	active site
459424010050	NAD binding site [chemical binding]; other site
459424010051	metal binding site [ion binding]; metal-binding site
459424010052	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
459424010053	YCII-related domain; Region: YCII; cl00999
459424010054	haloalkane dehalogenase; Provisional; Region: PRK03592
459424010055	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
459424010056	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
459424010057	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010058	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010059	PE family; Region: PE; pfam00934
459424010060	Transcriptional regulator [Transcription]; Region: LysR; COG0583
459424010061	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
459424010062	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
459424010063	putative dimerization interface [polypeptide binding]; other site
459424010064	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
459424010065	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424010066	dimerization interface [polypeptide binding]; other site
459424010067	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424010068	cyclase homology domain; Region: CHD; cd07302
459424010069	nucleotidyl binding site; other site
459424010070	metal binding site [ion binding]; metal-binding site
459424010071	dimer interface [polypeptide binding]; other site
459424010072	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424010073	Predicted membrane protein [Function unknown]; Region: COG4325
459424010074	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
459424010075	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
459424010076	dimer interface [polypeptide binding]; other site
459424010077	ADP-ribose binding site [chemical binding]; other site
459424010078	active site
459424010079	nudix motif; other site
459424010080	metal binding site [ion binding]; metal-binding site
459424010081	PE family; Region: PE; pfam00934
459424010082	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
459424010083	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
459424010084	putative dimer interface [polypeptide binding]; other site
459424010085	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424010086	ligand binding site [chemical binding]; other site
459424010087	Zn binding site [ion binding]; other site
459424010088	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
459424010089	metal binding site [ion binding]; metal-binding site
459424010090	Rrf2 family protein; Region: rrf2_super; TIGR00738
459424010091	Transcriptional regulator; Region: Rrf2; pfam02082
459424010092	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
459424010093	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
459424010094	CysD dimerization site [polypeptide binding]; other site
459424010095	G1 box; other site
459424010096	putative GEF interaction site [polypeptide binding]; other site
459424010097	GTP/Mg2+ binding site [chemical binding]; other site
459424010098	Switch I region; other site
459424010099	G2 box; other site
459424010100	G3 box; other site
459424010101	Switch II region; other site
459424010102	G4 box; other site
459424010103	G5 box; other site
459424010104	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
459424010105	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
459424010106	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
459424010107	ligand-binding site [chemical binding]; other site
459424010108	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
459424010109	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
459424010110	Active Sites [active]
459424010111	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010112	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010113	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010114	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
459424010115	CoenzymeA binding site [chemical binding]; other site
459424010116	subunit interaction site [polypeptide binding]; other site
459424010117	PHB binding site; other site
459424010118	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
459424010119	active site clefts [active]
459424010120	zinc binding site [ion binding]; other site
459424010121	dimer interface [polypeptide binding]; other site
459424010122	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
459424010123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424010124	dimer interface [polypeptide binding]; other site
459424010125	conserved gate region; other site
459424010126	putative PBP binding loops; other site
459424010127	ABC-ATPase subunit interface; other site
459424010128	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
459424010129	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424010130	dimer interface [polypeptide binding]; other site
459424010131	conserved gate region; other site
459424010132	putative PBP binding loops; other site
459424010133	ABC-ATPase subunit interface; other site
459424010134	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
459424010135	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
459424010136	Walker A/P-loop; other site
459424010137	ATP binding site [chemical binding]; other site
459424010138	Q-loop/lid; other site
459424010139	ABC transporter signature motif; other site
459424010140	Walker B; other site
459424010141	D-loop; other site
459424010142	H-loop/switch region; other site
459424010143	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
459424010144	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
459424010145	Walker A/P-loop; other site
459424010146	ATP binding site [chemical binding]; other site
459424010147	Q-loop/lid; other site
459424010148	ABC transporter signature motif; other site
459424010149	Walker B; other site
459424010150	D-loop; other site
459424010151	H-loop/switch region; other site
459424010152	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
459424010153	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
459424010154	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
459424010155	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424010156	choline dehydrogenase; Validated; Region: PRK02106
459424010157	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
459424010158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424010159	Walker A/P-loop; other site
459424010160	ATP binding site [chemical binding]; other site
459424010161	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
459424010162	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
459424010163	active site
459424010164	metal binding site [ion binding]; metal-binding site
459424010165	DNA binding site [nucleotide binding]
459424010166	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424010167	catalytic core [active]
459424010168	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
459424010169	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
459424010170	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
459424010171	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
459424010172	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424010173	Walker A/P-loop; other site
459424010174	ATP binding site [chemical binding]; other site
459424010175	Q-loop/lid; other site
459424010176	ABC transporter signature motif; other site
459424010177	Walker B; other site
459424010178	D-loop; other site
459424010179	H-loop/switch region; other site
459424010180	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
459424010181	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
459424010182	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
459424010183	Walker A/P-loop; other site
459424010184	ATP binding site [chemical binding]; other site
459424010185	Q-loop/lid; other site
459424010186	ABC transporter signature motif; other site
459424010187	Walker B; other site
459424010188	D-loop; other site
459424010189	H-loop/switch region; other site
459424010190	PE family; Region: PE; pfam00934
459424010191	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424010192	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424010193	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
459424010194	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
459424010195	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
459424010196	putative active site [active]
459424010197	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
459424010198	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
459424010199	DNA binding site [nucleotide binding]
459424010200	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424010201	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424010202	phosphopeptide binding site; other site
459424010203	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424010204	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424010205	active site
459424010206	ATP binding site [chemical binding]; other site
459424010207	substrate binding site [chemical binding]; other site
459424010208	activation loop (A-loop); other site
459424010209	Transcriptional regulator [Transcription]; Region: LysR; COG0583
459424010210	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
459424010211	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
459424010212	putative dimerization interface [polypeptide binding]; other site
459424010213	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
459424010214	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
459424010215	putative active site [active]
459424010216	putative catalytic site [active]
459424010217	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
459424010218	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
459424010219	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
459424010220	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424010221	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424010222	active site
459424010223	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
459424010224	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
459424010225	putative active site [active]
459424010226	catalytic site [active]
459424010227	putative metal binding site [ion binding]; other site
459424010228	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
459424010229	dimer interface [polypeptide binding]; other site
459424010230	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424010231	metal binding site [ion binding]; metal-binding site
459424010232	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
459424010233	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424010234	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424010235	active site
459424010236	ATP binding site [chemical binding]; other site
459424010237	substrate binding site [chemical binding]; other site
459424010238	activation loop (A-loop); other site
459424010239	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424010240	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424010241	phosphopeptide binding site; other site
459424010242	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
459424010243	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
459424010244	phosphopeptide binding site; other site
459424010245	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
459424010246	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
459424010247	Walker A/P-loop; other site
459424010248	ATP binding site [chemical binding]; other site
459424010249	Q-loop/lid; other site
459424010250	ABC transporter signature motif; other site
459424010251	Walker B; other site
459424010252	D-loop; other site
459424010253	H-loop/switch region; other site
459424010254	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
459424010255	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424010256	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424010257	active site
459424010258	ATP binding site [chemical binding]; other site
459424010259	substrate binding site [chemical binding]; other site
459424010260	activation loop (A-loop); other site
459424010261	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424010262	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424010263	cyclase homology domain; Region: CHD; cd07302
459424010264	nucleotidyl binding site; other site
459424010265	metal binding site [ion binding]; metal-binding site
459424010266	dimer interface [polypeptide binding]; other site
459424010267	amidase; Provisional; Region: PRK12470
459424010268	Amidase; Region: Amidase; cl11426
459424010269	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
459424010270	HIT family signature motif; other site
459424010271	catalytic residue [active]
459424010272	Domain of unknown function (DUF385); Region: DUF385; pfam04075
459424010273	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
459424010274	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424010275	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
459424010276	Fe-S cluster binding site [ion binding]; other site
459424010277	DNA binding site [nucleotide binding]
459424010278	active site
459424010279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424010280	H+ Antiporter protein; Region: 2A0121; TIGR00900
459424010281	putative substrate translocation pore; other site
459424010282	FAD binding domain; Region: FAD_binding_4; pfam01565
459424010283	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
459424010284	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424010285	Cytochrome P450; Region: p450; cl12078
459424010286	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010287	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010288	PE family; Region: PE; pfam00934
459424010289	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010290	PPE family; Region: PPE; pfam00823
459424010291	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
459424010292	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
459424010293	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
459424010294	ATP binding site [chemical binding]; other site
459424010295	Mg++ binding site [ion binding]; other site
459424010296	motif III; other site
459424010297	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
459424010298	nucleotide binding region [chemical binding]; other site
459424010299	ATP-binding site [chemical binding]; other site
459424010300	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
459424010301	putative RNA binding site [nucleotide binding]; other site
459424010302	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
459424010303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424010304	Major Facilitator Superfamily; Region: MFS_1; pfam07690
459424010305	putative substrate translocation pore; other site
459424010306	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
459424010307	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
459424010308	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
459424010309	TPP-binding site [chemical binding]; other site
459424010310	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
459424010311	dimer interface [polypeptide binding]; other site
459424010312	PYR/PP interface [polypeptide binding]; other site
459424010313	TPP binding site [chemical binding]; other site
459424010314	classical (c) SDRs; Region: SDR_c; cd05233
459424010315	short chain dehydrogenase; Provisional; Region: PRK08267
459424010316	NAD(P) binding site [chemical binding]; other site
459424010317	active site
459424010318	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
459424010319	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
459424010320	Malic enzyme, N-terminal domain; Region: malic; pfam00390
459424010321	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
459424010322	putative NAD(P) binding site [chemical binding]; other site
459424010323	malate dehydrogenase; Provisional; Region: PRK05442
459424010324	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
459424010325	NAD(P) binding site [chemical binding]; other site
459424010326	dimer interface [polypeptide binding]; other site
459424010327	malate binding site [chemical binding]; other site
459424010328	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
459424010329	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
459424010330	oligomer interface [polypeptide binding]; other site
459424010331	metal binding site [ion binding]; metal-binding site
459424010332	metal binding site [ion binding]; metal-binding site
459424010333	putative Cl binding site [ion binding]; other site
459424010334	basic sphincter; other site
459424010335	hydrophobic gate; other site
459424010336	periplasmic entrance; other site
459424010337	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424010338	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
459424010339	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
459424010340	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
459424010341	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
459424010342	Walker A/P-loop; other site
459424010343	ATP binding site [chemical binding]; other site
459424010344	Q-loop/lid; other site
459424010345	ABC transporter signature motif; other site
459424010346	Walker B; other site
459424010347	D-loop; other site
459424010348	H-loop/switch region; other site
459424010349	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
459424010350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424010351	dimer interface [polypeptide binding]; other site
459424010352	conserved gate region; other site
459424010353	ABC-ATPase subunit interface; other site
459424010354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424010355	dimer interface [polypeptide binding]; other site
459424010356	conserved gate region; other site
459424010357	putative PBP binding loops; other site
459424010358	ABC-ATPase subunit interface; other site
459424010359	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
459424010360	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
459424010361	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
459424010362	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
459424010363	MgtE intracellular N domain; Region: MgtE_N; smart00924
459424010364	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
459424010365	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
459424010366	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
459424010367	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
459424010368	N-acetyl-D-glucosamine binding site [chemical binding]; other site
459424010369	catalytic residue [active]
459424010370	Domain of unknown function DUF59; Region: DUF59; cl00941
459424010371	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
459424010372	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
459424010373	sec-independent translocase; Provisional; Region: PRK03100
459424010374	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
459424010375	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
459424010376	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
459424010377	protein binding site [polypeptide binding]; other site
459424010378	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
459424010379	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424010380	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
459424010381	DNA binding residues [nucleotide binding]
459424010382	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
459424010383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424010384	S-adenosylmethionine binding site [chemical binding]; other site
459424010385	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010386	PPE family; Region: PPE; pfam00823
459424010387	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
459424010388	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010389	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010390	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
459424010391	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
459424010392	Walker A/P-loop; other site
459424010393	ATP binding site [chemical binding]; other site
459424010394	Q-loop/lid; other site
459424010395	ABC transporter signature motif; other site
459424010396	Walker B; other site
459424010397	D-loop; other site
459424010398	H-loop/switch region; other site
459424010399	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
459424010400	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
459424010401	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
459424010402	PE family; Region: PE; pfam00934
459424010403	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
459424010404	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
459424010405	ligand binding site; other site
459424010406	oligomer interface; other site
459424010407	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
459424010408	dimer interface [polypeptide binding]; other site
459424010409	N-terminal domain interface [polypeptide binding]; other site
459424010410	sulfate 1 binding site; other site
459424010411	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
459424010412	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
459424010413	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
459424010414	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
459424010415	DivIVA domain; Region: DivI1A_domain; TIGR03544
459424010416	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
459424010417	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
459424010418	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
459424010419	dihydropteroate synthase; Region: DHPS; TIGR01496
459424010420	substrate binding pocket [chemical binding]; other site
459424010421	dimer interface [polypeptide binding]; other site
459424010422	inhibitor binding site; inhibition site
459424010423	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
459424010424	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
459424010425	acyl-activating enzyme (AAE) consensus motif; other site
459424010426	putative AMP binding site [chemical binding]; other site
459424010427	putative active site [active]
459424010428	putative CoA binding site [chemical binding]; other site
459424010429	TIGR00730 family protein; Region: TIGR00730
459424010430	AAA ATPase domain; Region: AAA_16; pfam13191
459424010431	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
459424010432	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
459424010433	metal binding site [ion binding]; metal-binding site
459424010434	putative dimer interface [polypeptide binding]; other site
459424010435	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
459424010436	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
459424010437	putative trimer interface [polypeptide binding]; other site
459424010438	putative CoA binding site [chemical binding]; other site
459424010439	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424010440	putative DNA binding site [nucleotide binding]; other site
459424010441	putative Zn2+ binding site [ion binding]; other site
459424010442	metabolite-proton symporter; Region: 2A0106; TIGR00883
459424010443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424010444	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010445	PPE family; Region: PPE; pfam00823
459424010446	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424010447	PE family; Region: PE; pfam00934
459424010448	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010449	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010450	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010451	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
459424010452	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424010453	acyl-CoA synthetase; Validated; Region: PRK07787
459424010454	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424010455	acyl-activating enzyme (AAE) consensus motif; other site
459424010456	AMP binding site [chemical binding]; other site
459424010457	active site
459424010458	CoA binding site [chemical binding]; other site
459424010459	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424010460	PGAP1-like protein; Region: PGAP1; pfam07819
459424010461	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424010462	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
459424010463	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
459424010464	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424010465	active site
459424010466	catalytic site [active]
459424010467	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
459424010468	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
459424010469	DUF35 OB-fold domain; Region: DUF35; pfam01796
459424010470	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
459424010471	putative active site [active]
459424010472	putative catalytic site [active]
459424010473	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010474	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010475	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010476	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010477	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010478	Proline dehydrogenase; Region: Pro_dh; cl03282
459424010479	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
459424010480	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
459424010481	Glutamate binding site [chemical binding]; other site
459424010482	NAD binding site [chemical binding]; other site
459424010483	catalytic residues [active]
459424010484	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
459424010485	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424010486	Stf0 sulphotransferase; Region: Sulphotransf; pfam09037
459424010487	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
459424010488	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424010489	putative substrate translocation pore; other site
459424010490	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010491	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010492	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010493	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
459424010494	ATP-sulfurylase; Region: ATPS; cd00517
459424010495	active site
459424010496	HXXH motif; other site
459424010497	flexible loop; other site
459424010498	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010499	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010500	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010501	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010502	PPE family; Region: PPE; pfam00823
459424010503	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010504	PPE family; Region: PPE; pfam00823
459424010505	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424010506	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010507	PPE family; Region: PPE; pfam00823
459424010508	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424010509	PE family; Region: PE; pfam00934
459424010510	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010511	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010512	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010513	Ferredoxin [Energy production and conversion]; Region: COG1146
459424010514	4Fe-4S binding domain; Region: Fer4; pfam00037
459424010515	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
459424010516	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424010517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424010518	homodimer interface [polypeptide binding]; other site
459424010519	catalytic residue [active]
459424010520	Predicted transcriptional regulators [Transcription]; Region: COG1695
459424010521	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
459424010522	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
459424010523	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
459424010524	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
459424010525	active site
459424010526	FMN binding site [chemical binding]; other site
459424010527	2,4-decadienoyl-CoA binding site; other site
459424010528	catalytic residue [active]
459424010529	4Fe-4S cluster binding site [ion binding]; other site
459424010530	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
459424010531	FO synthase; Reviewed; Region: fbiC; PRK09234
459424010532	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424010533	FeS/SAM binding site; other site
459424010534	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424010535	FeS/SAM binding site; other site
459424010536	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
459424010537	PE family; Region: PE; pfam00934
459424010538	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
459424010539	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
459424010540	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
459424010541	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
459424010542	G1 box; other site
459424010543	putative GEF interaction site [polypeptide binding]; other site
459424010544	GTP/Mg2+ binding site [chemical binding]; other site
459424010545	Switch I region; other site
459424010546	G2 box; other site
459424010547	G3 box; other site
459424010548	Switch II region; other site
459424010549	G4 box; other site
459424010550	G5 box; other site
459424010551	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
459424010552	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
459424010553	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
459424010554	active site
459424010555	8-oxo-dGMP binding site [chemical binding]; other site
459424010556	nudix motif; other site
459424010557	metal binding site [ion binding]; metal-binding site
459424010558	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
459424010559	aromatic arch; other site
459424010560	DCoH dimer interaction site [polypeptide binding]; other site
459424010561	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
459424010562	DCoH tetramer interaction site [polypeptide binding]; other site
459424010563	substrate binding site [chemical binding]; other site
459424010564	mannosyltransferase; Provisional; Region: pimE; PRK13375
459424010565	uncharacterized HhH-GPD family protein; Region: TIGR03252
459424010566	minor groove reading motif; other site
459424010567	helix-hairpin-helix signature motif; other site
459424010568	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010569	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010570	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010571	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010572	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010573	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010574	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010575	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
459424010576	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
459424010577	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010578	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010579	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010580	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
459424010581	Predicted transcriptional regulators [Transcription]; Region: COG1725
459424010582	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424010583	DNA-binding site [nucleotide binding]; DNA binding site
459424010584	NAD-dependent deacetylase; Provisional; Region: PRK00481
459424010585	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
459424010586	NAD+ binding site [chemical binding]; other site
459424010587	substrate binding site [chemical binding]; other site
459424010588	Zn binding site [ion binding]; other site
459424010589	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424010590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424010591	S-adenosylmethionine binding site [chemical binding]; other site
459424010592	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010593	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010594	WHG domain; Region: WHG; pfam13305
459424010595	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
459424010596	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
459424010597	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424010598	NAD(P) binding site [chemical binding]; other site
459424010599	active site
459424010600	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424010601	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424010602	enoyl-CoA hydratase; Provisional; Region: PRK06688
459424010603	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424010604	substrate binding site [chemical binding]; other site
459424010605	oxyanion hole (OAH) forming residues; other site
459424010606	trimer interface [polypeptide binding]; other site
459424010607	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
459424010608	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
459424010609	putative NAD(P) binding site [chemical binding]; other site
459424010610	putative active site [active]
459424010611	CAAX protease self-immunity; Region: Abi; pfam02517
459424010612	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424010613	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
459424010614	NAD(P) binding site [chemical binding]; other site
459424010615	active site
459424010616	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
459424010617	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
459424010618	malonyl-CoA binding site [chemical binding]; other site
459424010619	dimer interface [polypeptide binding]; other site
459424010620	active site
459424010621	product binding site; other site
459424010622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
459424010623	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
459424010624	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010625	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010626	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010627	enoyl-CoA hydratase; Provisional; Region: PRK08252
459424010628	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424010629	substrate binding site [chemical binding]; other site
459424010630	oxyanion hole (OAH) forming residues; other site
459424010631	trimer interface [polypeptide binding]; other site
459424010632	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
459424010633	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424010634	dimer interface [polypeptide binding]; other site
459424010635	active site
459424010636	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010637	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010638	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010639	PE family; Region: PE; pfam00934
459424010640	PE-PPE domain; Region: PE-PPE; pfam08237
459424010641	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
459424010642	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
459424010643	NAD binding site [chemical binding]; other site
459424010644	catalytic residues [active]
459424010645	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010646	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010647	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010648	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010649	PPE family; Region: PPE; pfam00823
459424010650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010651	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010652	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010653	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010654	short chain dehydrogenase; Provisional; Region: PRK12829
459424010655	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424010656	NAD(P) binding site [chemical binding]; other site
459424010657	active site
459424010658	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
459424010659	NADH(P)-binding; Region: NAD_binding_10; pfam13460
459424010660	NAD(P) binding site [chemical binding]; other site
459424010661	putative active site [active]
459424010662	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
459424010663	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
459424010664	THF binding site; other site
459424010665	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
459424010666	substrate binding site [chemical binding]; other site
459424010667	THF binding site; other site
459424010668	zinc-binding site [ion binding]; other site
459424010669	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
459424010670	Predicted membrane protein [Function unknown]; Region: COG2259
459424010671	pyruvate phosphate dikinase; Provisional; Region: PRK05878
459424010672	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
459424010673	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
459424010674	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424010675	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424010676	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010677	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010678	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
459424010679	dimer interface [polypeptide binding]; other site
459424010680	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010681	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010682	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010683	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
459424010684	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
459424010685	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
459424010686	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
459424010687	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
459424010688	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424010689	cyclase homology domain; Region: CHD; cd07302
459424010690	nucleotidyl binding site; other site
459424010691	metal binding site [ion binding]; metal-binding site
459424010692	dimer interface [polypeptide binding]; other site
459424010693	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
459424010694	Uncharacterized conserved protein [Function unknown]; Region: COG1359
459424010695	OsmC-like protein; Region: OsmC; pfam02566
459424010696	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010697	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010698	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010699	PPE family; Region: PPE; pfam00823
459424010700	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
459424010701	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010702	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010703	GTP-binding protein YchF; Reviewed; Region: PRK09601
459424010704	YchF GTPase; Region: YchF; cd01900
459424010705	G1 box; other site
459424010706	GTP/Mg2+ binding site [chemical binding]; other site
459424010707	Switch I region; other site
459424010708	G2 box; other site
459424010709	Switch II region; other site
459424010710	G3 box; other site
459424010711	G4 box; other site
459424010712	G5 box; other site
459424010713	Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071
459424010714	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
459424010715	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
459424010716	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
459424010717	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
459424010718	generic binding surface II; other site
459424010719	generic binding surface I; other site
459424010720	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
459424010721	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
459424010722	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
459424010723	putative NAD(P) binding site [chemical binding]; other site
459424010724	active site
459424010725	putative substrate binding site [chemical binding]; other site
459424010726	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
459424010727	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010728	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010729	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010730	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
459424010731	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
459424010732	substrate binding pocket [chemical binding]; other site
459424010733	catalytic triad [active]
459424010734	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
459424010735	Domain of unknown function DUF20; Region: UPF0118; pfam01594
459424010736	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
459424010737	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
459424010738	putative active site [active]
459424010739	fumarate hydratase; Reviewed; Region: fumC; PRK00485
459424010740	Class II fumarases; Region: Fumarase_classII; cd01362
459424010741	active site
459424010742	tetramer interface [polypeptide binding]; other site
459424010743	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
459424010744	dimerization interface [polypeptide binding]; other site
459424010745	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424010746	cyclase homology domain; Region: CHD; cd07302
459424010747	nucleotidyl binding site; other site
459424010748	metal binding site [ion binding]; metal-binding site
459424010749	dimer interface [polypeptide binding]; other site
459424010750	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
459424010751	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
459424010752	NodB motif; other site
459424010753	active site
459424010754	catalytic site [active]
459424010755	metal binding site [ion binding]; metal-binding site
459424010756	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
459424010757	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
459424010758	putative active site [active]
459424010759	PhoH-like protein; Region: PhoH; pfam02562
459424010760	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
459424010761	dinuclear metal binding motif [ion binding]; other site
459424010762	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
459424010763	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
459424010764	dimer interface [polypeptide binding]; other site
459424010765	active site
459424010766	glycine-pyridoxal phosphate binding site [chemical binding]; other site
459424010767	folate binding site [chemical binding]; other site
459424010768	pantothenate kinase; Provisional; Region: PRK05439
459424010769	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
459424010770	ATP-binding site [chemical binding]; other site
459424010771	CoA-binding site [chemical binding]; other site
459424010772	Mg2+-binding site [ion binding]; other site
459424010773	PE family; Region: PE; pfam00934
459424010774	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
459424010775	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
459424010776	catalytic residue [active]
459424010777	putative FPP diphosphate  binding site; other site
459424010778	putative FPP binding hydrophobic cleft; other site
459424010779	dimer interface [polypeptide binding]; other site
459424010780	putative IPP diphosphate binding site; other site
459424010781	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
459424010782	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
459424010783	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
459424010784	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
459424010785	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
459424010786	catalytic residues [active]
459424010787	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
459424010788	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
459424010789	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
459424010790	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
459424010791	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
459424010792	cystathionine gamma-synthase; Provisional; Region: PRK07811
459424010793	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
459424010794	homodimer interface [polypeptide binding]; other site
459424010795	substrate-cofactor binding pocket; other site
459424010796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424010797	catalytic residue [active]
459424010798	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
459424010799	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
459424010800	dimer interface [polypeptide binding]; other site
459424010801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424010802	catalytic residue [active]
459424010803	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
459424010804	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
459424010805	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
459424010806	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
459424010807	active site
459424010808	catalytic triad [active]
459424010809	oxyanion hole [active]
459424010810	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
459424010811	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424010812	dimer interface [polypeptide binding]; other site
459424010813	active site
459424010814	Predicted membrane protein [Function unknown]; Region: COG4760
459424010815	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
459424010816	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424010817	substrate binding site [chemical binding]; other site
459424010818	oxyanion hole (OAH) forming residues; other site
459424010819	trimer interface [polypeptide binding]; other site
459424010820	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
459424010821	enoyl-CoA hydratase; Provisional; Region: PRK05862
459424010822	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424010823	substrate binding site [chemical binding]; other site
459424010824	oxyanion hole (OAH) forming residues; other site
459424010825	trimer interface [polypeptide binding]; other site
459424010826	Predicted membrane protein [Function unknown]; Region: COG4425
459424010827	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
459424010828	PE family; Region: PE; pfam00934
459424010829	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
459424010830	active site residue [active]
459424010831	hypothetical protein; Provisional; Region: PRK10279
459424010832	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
459424010833	active site
459424010834	nucleophile elbow; other site
459424010835	Patatin-like phospholipase; Region: Patatin; pfam01734
459424010836	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
459424010837	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
459424010838	putative active site [active]
459424010839	putative dimer interface [polypeptide binding]; other site
459424010840	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
459424010841	hydrophobic ligand binding site; other site
459424010842	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010843	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010844	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010845	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
459424010846	Uncharacterized conserved protein [Function unknown]; Region: COG1262
459424010847	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
459424010848	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
459424010849	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
459424010850	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
459424010851	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
459424010852	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
459424010853	dimer interface [polypeptide binding]; other site
459424010854	acyl-activating enzyme (AAE) consensus motif; other site
459424010855	putative active site [active]
459424010856	AMP binding site [chemical binding]; other site
459424010857	putative CoA binding site [chemical binding]; other site
459424010858	Uncharacterized conserved protein [Function unknown]; Region: COG3391
459424010859	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
459424010860	Domain of unknown function (DUF385); Region: DUF385; cl04387
459424010861	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
459424010862	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010863	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010864	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
459424010865	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
459424010866	hydroxyglutarate oxidase; Provisional; Region: PRK11728
459424010867	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
459424010868	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
459424010869	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
459424010870	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
459424010871	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
459424010872	Transcriptional regulator [Transcription]; Region: IclR; COG1414
459424010873	Bacterial transcriptional regulator; Region: IclR; pfam01614
459424010874	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
459424010875	putative active site [active]
459424010876	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
459424010877	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
459424010878	haloalkane dehalogenase; Provisional; Region: PRK03204
459424010879	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
459424010880	catalytic site [active]
459424010881	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424010882	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424010883	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424010884	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424010885	Cytochrome P450; Region: p450; cl12078
459424010886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424010887	Coenzyme A binding pocket [chemical binding]; other site
459424010888	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
459424010889	Protein of unknown function (DUF3419); Region: DUF3419; cl15422
459424010890	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424010891	dimerization interface [polypeptide binding]; other site
459424010892	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424010893	cyclase homology domain; Region: CHD; cd07302
459424010894	nucleotidyl binding site; other site
459424010895	metal binding site [ion binding]; metal-binding site
459424010896	dimer interface [polypeptide binding]; other site
459424010897	PE family; Region: PE; pfam00934
459424010898	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424010899	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424010900	PPE family; Region: PPE; pfam00823
459424010901	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
459424010902	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424010903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424010904	active site
459424010905	phosphorylation site [posttranslational modification]
459424010906	intermolecular recognition site; other site
459424010907	dimerization interface [polypeptide binding]; other site
459424010908	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424010909	DNA binding site [nucleotide binding]
459424010910	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
459424010911	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
459424010912	dimer interface [polypeptide binding]; other site
459424010913	phosphorylation site [posttranslational modification]
459424010914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424010915	ATP binding site [chemical binding]; other site
459424010916	Mg2+ binding site [ion binding]; other site
459424010917	G-X-G motif; other site
459424010918	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
459424010919	exopolyphosphatase; Region: exo_poly_only; TIGR03706
459424010920	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
459424010921	Uncharacterized conserved protein [Function unknown]; Region: COG1507
459424010922	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
459424010923	Septum formation initiator; Region: DivIC; pfam04977
459424010924	enolase; Provisional; Region: eno; PRK00077
459424010925	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
459424010926	dimer interface [polypeptide binding]; other site
459424010927	metal binding site [ion binding]; metal-binding site
459424010928	substrate binding pocket [chemical binding]; other site
459424010929	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
459424010930	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
459424010931	N-acetyl-D-glucosamine binding site [chemical binding]; other site
459424010932	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333
459424010933	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
459424010934	homodimer interface [polypeptide binding]; other site
459424010935	metal binding site [ion binding]; metal-binding site
459424010936	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
459424010937	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
459424010938	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
459424010939	ATP binding site [chemical binding]; other site
459424010940	putative Mg++ binding site [ion binding]; other site
459424010941	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
459424010942	nucleotide binding region [chemical binding]; other site
459424010943	ATP-binding site [chemical binding]; other site
459424010944	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
459424010945	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424010946	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424010947	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
459424010948	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
459424010949	Substrate binding site; other site
459424010950	Mg++ binding site; other site
459424010951	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
459424010952	active site
459424010953	substrate binding site [chemical binding]; other site
459424010954	CoA binding site [chemical binding]; other site
459424010955	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
459424010956	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
459424010957	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
459424010958	active site
459424010959	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
459424010960	ArsC family; Region: ArsC; pfam03960
459424010961	catalytic residues [active]
459424010962	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
459424010963	short chain dehydrogenase; Provisional; Region: PRK06197
459424010964	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
459424010965	putative NAD(P) binding site [chemical binding]; other site
459424010966	active site
459424010967	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
459424010968	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
459424010969	5S rRNA interface [nucleotide binding]; other site
459424010970	CTC domain interface [polypeptide binding]; other site
459424010971	L16 interface [polypeptide binding]; other site
459424010972	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
459424010973	putative active site [active]
459424010974	catalytic residue [active]
459424010975	Domain of unknown function DUF302; Region: DUF302; pfam03625
459424010976	Domain of unknown function DUF302; Region: DUF302; pfam03625
459424010977	PE family; Region: PE; pfam00934
459424010978	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
459424010979	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424010980	acyl-activating enzyme (AAE) consensus motif; other site
459424010981	active site
459424010982	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
459424010983	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
459424010984	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
459424010985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424010986	S-adenosylmethionine binding site [chemical binding]; other site
459424010987	Domain of unknown function (DUF348); Region: DUF348; pfam03990
459424010988	Domain of unknown function (DUF348); Region: DUF348; pfam03990
459424010989	G5 domain; Region: G5; pfam07501
459424010990	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
459424010991	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
459424010992	active site
459424010993	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
459424010994	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
459424010995	active site
459424010996	HIGH motif; other site
459424010997	KMSKS motif; other site
459424010998	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
459424010999	tRNA binding surface [nucleotide binding]; other site
459424011000	anticodon binding site; other site
459424011001	colanic acid biosynthesis acetyltransferase WcaB; Region: WcaB; TIGR04016
459424011002	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
459424011003	trimer interface [polypeptide binding]; other site
459424011004	active site
459424011005	substrate binding site [chemical binding]; other site
459424011006	CoA binding site [chemical binding]; other site
459424011007	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
459424011008	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424011009	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424011010	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
459424011011	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424011012	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
459424011013	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
459424011014	chorismate binding enzyme; Region: Chorismate_bind; cl10555
459424011015	Predicted methyltransferases [General function prediction only]; Region: COG0313
459424011016	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
459424011017	putative SAM binding site [chemical binding]; other site
459424011018	putative homodimer interface [polypeptide binding]; other site
459424011019	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
459424011020	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
459424011021	arginine deiminase; Provisional; Region: PRK01388
459424011022	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
459424011023	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424011024	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424011025	ligand binding site [chemical binding]; other site
459424011026	flexible hinge region; other site
459424011027	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
459424011028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424011029	Coenzyme A binding pocket [chemical binding]; other site
459424011030	Methyltransferase domain; Region: Methyltransf_31; pfam13847
459424011031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424011032	S-adenosylmethionine binding site [chemical binding]; other site
459424011033	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
459424011034	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424011035	PPE family; Region: PPE; pfam00823
459424011036	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
459424011037	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
459424011038	Bacterial sugar transferase; Region: Bac_transf; pfam02397
459424011039	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
459424011040	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
459424011041	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
459424011042	active site
459424011043	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
459424011044	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
459424011045	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424011046	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
459424011047	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424011048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424011049	S-adenosylmethionine binding site [chemical binding]; other site
459424011050	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
459424011051	Methyltransferase domain; Region: Methyltransf_23; pfam13489
459424011052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424011053	S-adenosylmethionine binding site [chemical binding]; other site
459424011054	Methyltransferase domain; Region: Methyltransf_11; pfam08241
459424011055	Predicted amidohydrolase [General function prediction only]; Region: COG0388
459424011056	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
459424011057	active site
459424011058	catalytic triad [active]
459424011059	dimer interface [polypeptide binding]; other site
459424011060	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424011061	S-adenosylmethionine binding site [chemical binding]; other site
459424011062	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
459424011063	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
459424011064	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
459424011065	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
459424011066	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
459424011067	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
459424011068	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
459424011069	dimer interface [polypeptide binding]; other site
459424011070	putative functional site; other site
459424011071	putative MPT binding site; other site
459424011072	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
459424011073	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
459424011074	active site
459424011075	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
459424011076	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
459424011077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
459424011078	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
459424011079	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
459424011080	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
459424011081	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
459424011082	MPT binding site; other site
459424011083	trimer interface [polypeptide binding]; other site
459424011084	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
459424011085	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
459424011086	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
459424011087	protein binding site [polypeptide binding]; other site
459424011088	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
459424011089	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424011090	dimerization interface [polypeptide binding]; other site
459424011091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
459424011092	dimer interface [polypeptide binding]; other site
459424011093	phosphorylation site [posttranslational modification]
459424011094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424011095	ATP binding site [chemical binding]; other site
459424011096	Mg2+ binding site [ion binding]; other site
459424011097	G-X-G motif; other site
459424011098	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424011099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424011100	active site
459424011101	phosphorylation site [posttranslational modification]
459424011102	intermolecular recognition site; other site
459424011103	dimerization interface [polypeptide binding]; other site
459424011104	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424011105	DNA binding site [nucleotide binding]
459424011106	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
459424011107	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011108	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011109	active site
459424011110	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
459424011111	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
459424011112	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
459424011113	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
459424011114	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
459424011115	ATP-grasp domain; Region: ATP-grasp_4; cl17255
459424011116	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
459424011117	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
459424011118	carboxyltransferase (CT) interaction site; other site
459424011119	biotinylation site [posttranslational modification]; other site
459424011120	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011121	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
459424011122	active site
459424011123	enoyl-CoA hydratase; Provisional; Region: PRK07827
459424011124	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424011125	substrate binding site [chemical binding]; other site
459424011126	oxyanion hole (OAH) forming residues; other site
459424011127	trimer interface [polypeptide binding]; other site
459424011128	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
459424011129	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
459424011130	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
459424011131	metal ion-dependent adhesion site (MIDAS); other site
459424011132	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
459424011133	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
459424011134	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
459424011135	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
459424011136	purine monophosphate binding site [chemical binding]; other site
459424011137	dimer interface [polypeptide binding]; other site
459424011138	putative catalytic residues [active]
459424011139	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
459424011140	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
459424011141	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
459424011142	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
459424011143	active site
459424011144	substrate binding site [chemical binding]; other site
459424011145	cosubstrate binding site; other site
459424011146	catalytic site [active]
459424011147	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424011148	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424011149	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
459424011150	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
459424011151	active site
459424011152	PE family; Region: PE; pfam00934
459424011153	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
459424011154	CoA binding domain; Region: CoA_binding; smart00881
459424011155	CoA-ligase; Region: Ligase_CoA; pfam00549
459424011156	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
459424011157	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
459424011158	CoA-ligase; Region: Ligase_CoA; pfam00549
459424011159	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
459424011160	Peptidase family M23; Region: Peptidase_M23; pfam01551
459424011161	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
459424011162	Part of AAA domain; Region: AAA_19; pfam13245
459424011163	Family description; Region: UvrD_C_2; pfam13538
459424011164	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424011165	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011166	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011167	Chorismate mutase type II; Region: CM_2; cl00693
459424011168	Putative esterase; Region: Esterase; pfam00756
459424011169	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
459424011170	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
459424011171	active site
459424011172	dimer interface [polypeptide binding]; other site
459424011173	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
459424011174	dimer interface [polypeptide binding]; other site
459424011175	active site
459424011176	short chain dehydrogenase; Provisional; Region: PRK08251
459424011177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424011178	NAD(P) binding site [chemical binding]; other site
459424011179	active site
459424011180	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
459424011181	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
459424011182	putative DNA binding site [nucleotide binding]; other site
459424011183	catalytic residue [active]
459424011184	putative H2TH interface [polypeptide binding]; other site
459424011185	putative catalytic residues [active]
459424011186	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
459424011187	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
459424011188	PE family; Region: PE; pfam00934
459424011189	PE family; Region: PE; pfam00934
459424011190	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
459424011191	active site
459424011192	SAM binding site [chemical binding]; other site
459424011193	homodimer interface [polypeptide binding]; other site
459424011194	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
459424011195	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
459424011196	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424011197	NAD binding site [chemical binding]; other site
459424011198	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424011199	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424011200	enoyl-CoA hydratase; Provisional; Region: PRK06688
459424011201	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424011202	substrate binding site [chemical binding]; other site
459424011203	oxyanion hole (OAH) forming residues; other site
459424011204	trimer interface [polypeptide binding]; other site
459424011205	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424011206	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424011207	PE family; Region: PE; pfam00934
459424011208	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
459424011209	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
459424011210	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
459424011211	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
459424011212	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
459424011213	nucleotide binding site [chemical binding]; other site
459424011214	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
459424011215	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
459424011216	active site
459424011217	DNA binding site [nucleotide binding]
459424011218	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
459424011219	DNA binding site [nucleotide binding]
459424011220	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
459424011221	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
459424011222	putative DNA binding site [nucleotide binding]; other site
459424011223	putative homodimer interface [polypeptide binding]; other site
459424011224	PBP superfamily domain; Region: PBP_like_2; cl17296
459424011225	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424011226	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424011227	active site
459424011228	ATP binding site [chemical binding]; other site
459424011229	substrate binding site [chemical binding]; other site
459424011230	activation loop (A-loop); other site
459424011231	Uncharacterized conserved protein [Function unknown]; Region: COG3391
459424011232	NHL repeat; Region: NHL; pfam01436
459424011233	NHL repeat; Region: NHL; pfam01436
459424011234	NHL repeat; Region: NHL; pfam01436
459424011235	NHL repeat; Region: NHL; pfam01436
459424011236	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
459424011237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424011238	dimer interface [polypeptide binding]; other site
459424011239	conserved gate region; other site
459424011240	putative PBP binding loops; other site
459424011241	ABC-ATPase subunit interface; other site
459424011242	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
459424011243	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424011244	dimer interface [polypeptide binding]; other site
459424011245	conserved gate region; other site
459424011246	putative PBP binding loops; other site
459424011247	ABC-ATPase subunit interface; other site
459424011248	PBP superfamily domain; Region: PBP_like_2; cl17296
459424011249	short chain dehydrogenase; Provisional; Region: PRK07814
459424011250	classical (c) SDRs; Region: SDR_c; cd05233
459424011251	NAD(P) binding site [chemical binding]; other site
459424011252	active site
459424011253	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
459424011254	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
459424011255	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
459424011256	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
459424011257	manganese transport protein MntH; Reviewed; Region: PRK00701
459424011258	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
459424011259	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
459424011260	putative active site pocket [active]
459424011261	dimerization interface [polypeptide binding]; other site
459424011262	putative catalytic residue [active]
459424011263	Protein of unknown function (DUF867); Region: DUF867; cl01713
459424011264	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
459424011265	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
459424011266	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424011267	active site 2 [active]
459424011268	PE family; Region: PE; pfam00934
459424011269	Transposase IS200 like; Region: Y1_Tnp; pfam01797
459424011270	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424011271	PPE family; Region: PPE; pfam00823
459424011272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424011273	S-adenosylmethionine binding site [chemical binding]; other site
459424011274	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
459424011275	PE family; Region: PE; pfam00934
459424011276	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424011277	PPE family; Region: PPE; pfam00823
459424011278	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424011279	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
459424011280	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
459424011281	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
459424011282	active site
459424011283	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
459424011284	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
459424011285	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424011286	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
459424011287	hydrophobic ligand binding site; other site
459424011288	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
459424011289	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011290	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011291	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424011292	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424011293	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
459424011294	Soluble P-type ATPase [General function prediction only]; Region: COG4087
459424011295	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
459424011296	Beta-lactamase; Region: Beta-lactamase; pfam00144
459424011297	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
459424011298	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
459424011299	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
459424011300	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424011301	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424011302	substrate binding site [chemical binding]; other site
459424011303	oxyanion hole (OAH) forming residues; other site
459424011304	trimer interface [polypeptide binding]; other site
459424011305	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
459424011306	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
459424011307	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424011308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424011309	putative substrate translocation pore; other site
459424011310	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
459424011311	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
459424011312	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424011313	catalytic residue [active]
459424011314	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
459424011315	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
459424011316	dimer interface [polypeptide binding]; other site
459424011317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424011318	catalytic residue [active]
459424011319	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424011320	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011321	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011322	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424011323	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424011324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424011325	active site
459424011326	phosphorylation site [posttranslational modification]
459424011327	intermolecular recognition site; other site
459424011328	dimerization interface [polypeptide binding]; other site
459424011329	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424011330	DNA binding site [nucleotide binding]
459424011331	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
459424011332	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424011333	dimerization interface [polypeptide binding]; other site
459424011334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
459424011335	dimer interface [polypeptide binding]; other site
459424011336	phosphorylation site [posttranslational modification]
459424011337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424011338	ATP binding site [chemical binding]; other site
459424011339	Mg2+ binding site [ion binding]; other site
459424011340	G-X-G motif; other site
459424011341	BON domain; Region: BON; pfam04972
459424011342	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
459424011343	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
459424011344	ligand binding site [chemical binding]; other site
459424011345	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
459424011346	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
459424011347	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424011348	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
459424011349	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
459424011350	dimer interface [polypeptide binding]; other site
459424011351	active site
459424011352	citrylCoA binding site [chemical binding]; other site
459424011353	NADH binding [chemical binding]; other site
459424011354	cationic pore residues; other site
459424011355	oxalacetate/citrate binding site [chemical binding]; other site
459424011356	coenzyme A binding site [chemical binding]; other site
459424011357	catalytic triad [active]
459424011358	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424011359	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424011360	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
459424011361	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
459424011362	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
459424011363	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
459424011364	dimer interface [polypeptide binding]; other site
459424011365	Citrate synthase; Region: Citrate_synt; pfam00285
459424011366	active site
459424011367	citrylCoA binding site [chemical binding]; other site
459424011368	oxalacetate/citrate binding site [chemical binding]; other site
459424011369	coenzyme A binding site [chemical binding]; other site
459424011370	catalytic triad [active]
459424011371	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
459424011372	putative catalytic site [active]
459424011373	putative phosphate binding site [ion binding]; other site
459424011374	putative metal binding site [ion binding]; other site
459424011375	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
459424011376	putative dimer interface [polypeptide binding]; other site
459424011377	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424011378	Ferredoxin [Energy production and conversion]; Region: COG1146
459424011379	4Fe-4S binding domain; Region: Fer4; pfam00037
459424011380	ferredoxin-NADP+ reductase; Region: PLN02852
459424011381	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424011382	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
459424011383	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
459424011384	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424011385	catalytic residue [active]
459424011386	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
459424011387	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
459424011388	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
459424011389	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
459424011390	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
459424011391	MarR family; Region: MarR; pfam01047
459424011392	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
459424011393	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
459424011394	hydrophobic ligand binding site; other site
459424011395	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
459424011396	H+ Antiporter protein; Region: 2A0121; TIGR00900
459424011397	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
459424011398	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
459424011399	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
459424011400	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
459424011401	putative dimer interface [polypeptide binding]; other site
459424011402	N-terminal domain interface [polypeptide binding]; other site
459424011403	putative substrate binding pocket (H-site) [chemical binding]; other site
459424011404	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011405	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
459424011406	active site
459424011407	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
459424011408	DNA-binding site [nucleotide binding]; DNA binding site
459424011409	RNA-binding motif; other site
459424011410	hypothetical protein; Provisional; Region: PRK11770
459424011411	Domain of unknown function (DUF307); Region: DUF307; pfam03733
459424011412	Domain of unknown function (DUF307); Region: DUF307; pfam03733
459424011413	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
459424011414	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
459424011415	FeS/SAM binding site; other site
459424011416	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
459424011417	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
459424011418	MoaE interaction surface [polypeptide binding]; other site
459424011419	MoeB interaction surface [polypeptide binding]; other site
459424011420	thiocarboxylated glycine; other site
459424011421	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
459424011422	MoaE homodimer interface [polypeptide binding]; other site
459424011423	MoaD interaction [polypeptide binding]; other site
459424011424	active site residues [active]
459424011425	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
459424011426	MPT binding site; other site
459424011427	trimer interface [polypeptide binding]; other site
459424011428	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
459424011429	trimer interface [polypeptide binding]; other site
459424011430	dimer interface [polypeptide binding]; other site
459424011431	putative active site [active]
459424011432	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
459424011433	WYL domain; Region: WYL; pfam13280
459424011434	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
459424011435	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
459424011436	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
459424011437	ATP binding site [chemical binding]; other site
459424011438	putative Mg++ binding site [ion binding]; other site
459424011439	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
459424011440	nucleotide binding region [chemical binding]; other site
459424011441	ATP-binding site [chemical binding]; other site
459424011442	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
459424011443	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424011444	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424011445	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424011446	hypothetical protein; Validated; Region: PRK05868
459424011447	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424011448	hypothetical protein; Provisional; Region: PRK07236
459424011449	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
459424011450	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424011451	substrate binding site [chemical binding]; other site
459424011452	oxyanion hole (OAH) forming residues; other site
459424011453	trimer interface [polypeptide binding]; other site
459424011454	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
459424011455	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
459424011456	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
459424011457	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424011458	dimer interface [polypeptide binding]; other site
459424011459	active site
459424011460	aminotransferase; Validated; Region: PRK07777
459424011461	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424011462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424011463	homodimer interface [polypeptide binding]; other site
459424011464	catalytic residue [active]
459424011465	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
459424011466	putative hydrophobic ligand binding site [chemical binding]; other site
459424011467	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
459424011468	putative hydrophobic ligand binding site [chemical binding]; other site
459424011469	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424011470	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424011471	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
459424011472	putative hydrophobic ligand binding site [chemical binding]; other site
459424011473	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
459424011474	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
459424011475	dimer interface [polypeptide binding]; other site
459424011476	PYR/PP interface [polypeptide binding]; other site
459424011477	TPP binding site [chemical binding]; other site
459424011478	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
459424011479	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
459424011480	TPP-binding site [chemical binding]; other site
459424011481	dimer interface [polypeptide binding]; other site
459424011482	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424011483	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
459424011484	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424011485	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424011486	substrate binding site [chemical binding]; other site
459424011487	oxyanion hole (OAH) forming residues; other site
459424011488	trimer interface [polypeptide binding]; other site
459424011489	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424011490	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424011491	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424011492	Cytochrome P450; Region: p450; cl12078
459424011493	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
459424011494	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
459424011495	Subunit I/III interface [polypeptide binding]; other site
459424011496	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424011497	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424011498	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424011499	mce related protein; Region: MCE; pfam02470
459424011500	mce related protein; Region: MCE; pfam02470
459424011501	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424011502	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424011503	mce related protein; Region: MCE; pfam02470
459424011504	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424011505	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424011506	mce related protein; Region: MCE; pfam02470
459424011507	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424011508	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011509	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011510	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
459424011511	Permease; Region: Permease; pfam02405
459424011512	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424011513	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424011514	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
459424011515	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
459424011516	NAD binding site [chemical binding]; other site
459424011517	catalytic residues [active]
459424011518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424011519	NAD(P) binding site [chemical binding]; other site
459424011520	active site
459424011521	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
459424011522	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424011523	Cytochrome P450; Region: p450; cl12078
459424011524	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011525	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011526	active site
459424011527	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011528	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424011529	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011530	active site
459424011531	SnoaL-like domain; Region: SnoaL_4; pfam13577
459424011532	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
459424011533	FMN binding site [chemical binding]; other site
459424011534	dimer interface [polypeptide binding]; other site
459424011535	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
459424011536	Phosphoesterase family; Region: Phosphoesterase; pfam04185
459424011537	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
459424011538	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424011539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424011540	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424011541	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
459424011542	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
459424011543	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
459424011544	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
459424011545	DUF35 OB-fold domain; Region: DUF35; pfam01796
459424011546	lipid-transfer protein; Provisional; Region: PRK07855
459424011547	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424011548	active site
459424011549	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424011550	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
459424011551	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424011552	Cytochrome P450; Region: p450; cl12078
459424011553	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
459424011554	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
459424011555	PE family; Region: PE; pfam00934
459424011556	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
459424011557	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424011558	Cytochrome P450; Region: p450; cl12078
459424011559	TetR family transcriptional regulator; Provisional; Region: PRK14996
459424011560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424011561	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
459424011562	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424011563	dimer interface [polypeptide binding]; other site
459424011564	active site
459424011565	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011566	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011567	active site
459424011568	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424011569	Uncharacterized conserved protein [Function unknown]; Region: COG2128
459424011570	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
459424011571	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
459424011572	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
459424011573	[2Fe-2S] cluster binding site [ion binding]; other site
459424011574	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
459424011575	alpha subunit interface [polypeptide binding]; other site
459424011576	active site
459424011577	substrate binding site [chemical binding]; other site
459424011578	Fe binding site [ion binding]; other site
459424011579	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011580	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011581	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424011582	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
459424011583	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424011584	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
459424011585	active site
459424011586	SnoaL-like domain; Region: SnoaL_4; pfam13577
459424011587	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011588	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011589	active site
459424011590	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011591	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011592	high affinity sulphate transporter 1; Region: sulP; TIGR00815
459424011593	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
459424011594	Sulfate transporter family; Region: Sulfate_transp; pfam00916
459424011595	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
459424011596	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011597	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011598	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011599	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011600	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424011601	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424011602	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424011603	Cytochrome P450; Region: p450; cl12078
459424011604	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
459424011605	classical (c) SDRs; Region: SDR_c; cd05233
459424011606	NAD(P) binding site [chemical binding]; other site
459424011607	active site
459424011608	short chain dehydrogenase; Provisional; Region: PRK05876
459424011609	classical (c) SDRs; Region: SDR_c; cd05233
459424011610	NAD(P) binding site [chemical binding]; other site
459424011611	active site
459424011612	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424011613	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424011614	NAD(P) binding site [chemical binding]; other site
459424011615	active site
459424011616	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424011617	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424011618	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424011619	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424011620	enoyl-CoA hydratase; Provisional; Region: PRK12478
459424011621	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424011622	substrate binding site [chemical binding]; other site
459424011623	oxyanion hole (OAH) forming residues; other site
459424011624	trimer interface [polypeptide binding]; other site
459424011625	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
459424011626	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
459424011627	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
459424011628	active site
459424011629	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
459424011630	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
459424011631	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
459424011632	active site
459424011633	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424011634	Cytochrome P450; Region: p450; cl12078
459424011635	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424011636	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
459424011637	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424011638	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
459424011639	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424011640	NAD(P) binding site [chemical binding]; other site
459424011641	active site
459424011642	NADH(P)-binding; Region: NAD_binding_10; pfam13460
459424011643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424011644	active site
459424011645	multidrug resistance protein MdtH; Provisional; Region: PRK11646
459424011646	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
459424011647	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
459424011648	dimer interface [polypeptide binding]; other site
459424011649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424011650	catalytic residue [active]
459424011651	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424011652	TAP-like protein; Region: Abhydrolase_4; pfam08386
459424011653	Putative cyclase; Region: Cyclase; pfam04199
459424011654	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
459424011655	NAD(P) binding site [chemical binding]; other site
459424011656	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
459424011657	active site
459424011658	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
459424011659	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
459424011660	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
459424011661	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
459424011662	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424011663	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424011664	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424011665	Transcriptional regulator [Transcription]; Region: IclR; COG1414
459424011666	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
459424011667	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
459424011668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424011669	ATP binding site [chemical binding]; other site
459424011670	Mg2+ binding site [ion binding]; other site
459424011671	G-X-G motif; other site
459424011672	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
459424011673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424011674	active site
459424011675	phosphorylation site [posttranslational modification]
459424011676	intermolecular recognition site; other site
459424011677	dimerization interface [polypeptide binding]; other site
459424011678	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
459424011679	DNA binding residues [nucleotide binding]
459424011680	dimerization interface [polypeptide binding]; other site
459424011681	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
459424011682	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
459424011683	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
459424011684	TPP-binding site [chemical binding]; other site
459424011685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424011686	Major Facilitator Superfamily; Region: MFS_1; pfam07690
459424011687	putative substrate translocation pore; other site
459424011688	PE family; Region: PE; pfam00934
459424011689	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
459424011690	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
459424011691	Walker A; other site
459424011692	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424011693	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
459424011694	dimer interface [polypeptide binding]; other site
459424011695	active site
459424011696	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
459424011697	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424011698	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424011699	substrate binding site [chemical binding]; other site
459424011700	oxyanion hole (OAH) forming residues; other site
459424011701	trimer interface [polypeptide binding]; other site
459424011702	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011703	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011704	active site
459424011705	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424011706	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424011707	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
459424011708	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424011709	acyl-activating enzyme (AAE) consensus motif; other site
459424011710	AMP binding site [chemical binding]; other site
459424011711	active site
459424011712	CoA binding site [chemical binding]; other site
459424011713	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
459424011714	CoA-transferase family III; Region: CoA_transf_3; pfam02515
459424011715	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
459424011716	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424011717	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
459424011718	B12 binding site [chemical binding]; other site
459424011719	cobalt ligand [ion binding]; other site
459424011720	Methyltransferase domain; Region: Methyltransf_31; pfam13847
459424011721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424011722	S-adenosylmethionine binding site [chemical binding]; other site
459424011723	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
459424011724	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011725	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011726	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424011727	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
459424011728	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
459424011729	substrate binding pocket [chemical binding]; other site
459424011730	chain length determination region; other site
459424011731	substrate-Mg2+ binding site; other site
459424011732	catalytic residues [active]
459424011733	aspartate-rich region 1; other site
459424011734	active site lid residues [active]
459424011735	aspartate-rich region 2; other site
459424011736	phytoene desaturase; Region: crtI_fam; TIGR02734
459424011737	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
459424011738	active site lid residues [active]
459424011739	substrate binding pocket [chemical binding]; other site
459424011740	catalytic residues [active]
459424011741	substrate-Mg2+ binding site; other site
459424011742	aspartate-rich region 1; other site
459424011743	aspartate-rich region 2; other site
459424011744	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
459424011745	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
459424011746	MMPL family; Region: MMPL; pfam03176
459424011747	MMPL family; Region: MMPL; pfam03176
459424011748	Transcriptional regulators [Transcription]; Region: MarR; COG1846
459424011749	MarR family; Region: MarR_2; pfam12802
459424011750	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
459424011751	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
459424011752	homotetramer interface [polypeptide binding]; other site
459424011753	FMN binding site [chemical binding]; other site
459424011754	homodimer contacts [polypeptide binding]; other site
459424011755	putative active site [active]
459424011756	putative substrate binding site [chemical binding]; other site
459424011757	RES domain; Region: RES; pfam08808
459424011758	Helix-turn-helix domain; Region: HTH_17; pfam12728
459424011759	L-asparagine permease; Provisional; Region: PRK15049
459424011760	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
459424011761	AAA domain; Region: AAA_28; pfam13521
459424011762	Predicted ATPase [General function prediction only]; Region: COG3911
459424011763	hypothetical protein; Provisional; Region: PRK06194
459424011764	classical (c) SDRs; Region: SDR_c; cd05233
459424011765	NAD(P) binding site [chemical binding]; other site
459424011766	active site
459424011767	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
459424011768	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424011769	Amidohydrolase; Region: Amidohydro_2; pfam04909
459424011770	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
459424011771	DNA-binding site [nucleotide binding]; DNA binding site
459424011772	RNA-binding motif; other site
459424011773	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
459424011774	DEAD-like helicases superfamily; Region: DEXDc; smart00487
459424011775	ATP binding site [chemical binding]; other site
459424011776	putative Mg++ binding site [ion binding]; other site
459424011777	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
459424011778	nucleotide binding region [chemical binding]; other site
459424011779	ATP-binding site [chemical binding]; other site
459424011780	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
459424011781	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
459424011782	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
459424011783	substrate binding pocket [chemical binding]; other site
459424011784	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
459424011785	B12 binding site [chemical binding]; other site
459424011786	cobalt ligand [ion binding]; other site
459424011787	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
459424011788	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
459424011789	active site
459424011790	NTP binding site [chemical binding]; other site
459424011791	metal binding triad [ion binding]; metal-binding site
459424011792	putative replication initiation protein; Region: PHA00330
459424011793	Helix-turn-helix domain; Region: HTH_17; pfam12728
459424011794	PIN domain; Region: PIN_3; pfam13470
459424011795	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424011796	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011797	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011798	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
459424011799	active site
459424011800	NTP binding site [chemical binding]; other site
459424011801	metal binding triad [ion binding]; metal-binding site
459424011802	Predicted helicase [General function prediction only]; Region: COG4889
459424011803	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
459424011804	nudix motif; other site
459424011805	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
459424011806	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
459424011807	DNA-binding site [nucleotide binding]; DNA binding site
459424011808	UTRA domain; Region: UTRA; pfam07702
459424011809	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424011810	Helix-turn-helix domain; Region: HTH_17; cl17695
459424011811	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
459424011812	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
459424011813	Int/Topo IB signature motif; other site
459424011814	TIGR04255 family protein; Region: sporadTIGR04255
459424011815	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
459424011816	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
459424011817	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
459424011818	nucleoside/Zn binding site; other site
459424011819	dimer interface [polypeptide binding]; other site
459424011820	catalytic motif [active]
459424011821	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424011822	dimerization interface [polypeptide binding]; other site
459424011823	putative DNA binding site [nucleotide binding]; other site
459424011824	putative Zn2+ binding site [ion binding]; other site
459424011825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
459424011826	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424011827	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
459424011828	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
459424011829	homodimer interface [polypeptide binding]; other site
459424011830	putative substrate binding pocket [chemical binding]; other site
459424011831	diiron center [ion binding]; other site
459424011832	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
459424011833	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
459424011834	FMN binding site [chemical binding]; other site
459424011835	active site
459424011836	catalytic residues [active]
459424011837	substrate binding site [chemical binding]; other site
459424011838	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
459424011839	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
459424011840	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
459424011841	PhoU domain; Region: PhoU; pfam01895
459424011842	PhoU domain; Region: PhoU; pfam01895
459424011843	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
459424011844	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
459424011845	Walker A/P-loop; other site
459424011846	ATP binding site [chemical binding]; other site
459424011847	Q-loop/lid; other site
459424011848	ABC transporter signature motif; other site
459424011849	Walker B; other site
459424011850	D-loop; other site
459424011851	H-loop/switch region; other site
459424011852	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
459424011853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424011854	dimer interface [polypeptide binding]; other site
459424011855	conserved gate region; other site
459424011856	putative PBP binding loops; other site
459424011857	ABC-ATPase subunit interface; other site
459424011858	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
459424011859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424011860	dimer interface [polypeptide binding]; other site
459424011861	conserved gate region; other site
459424011862	putative PBP binding loops; other site
459424011863	ABC-ATPase subunit interface; other site
459424011864	PBP superfamily domain; Region: PBP_like_2; cl17296
459424011865	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
459424011866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424011867	Coenzyme A binding pocket [chemical binding]; other site
459424011868	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
459424011869	Coenzyme A binding pocket [chemical binding]; other site
459424011870	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424011871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424011872	DNA binding site [nucleotide binding]
459424011873	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
459424011874	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
459424011875	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
459424011876	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
459424011877	active site residue [active]
459424011878	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
459424011879	active site residue [active]
459424011880	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
459424011881	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
459424011882	heme-binding site [chemical binding]; other site
459424011883	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
459424011884	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
459424011885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424011886	catalytic residue [active]
459424011887	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
459424011888	putative homodimer interface [polypeptide binding]; other site
459424011889	putative homotetramer interface [polypeptide binding]; other site
459424011890	allosteric switch controlling residues; other site
459424011891	putative metal binding site [ion binding]; other site
459424011892	putative homodimer-homodimer interface [polypeptide binding]; other site
459424011893	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
459424011894	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
459424011895	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
459424011896	Soluble P-type ATPase [General function prediction only]; Region: COG4087
459424011897	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424011898	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011899	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011900	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
459424011901	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
459424011902	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
459424011903	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
459424011904	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
459424011905	dimerization interface [polypeptide binding]; other site
459424011906	putative ATP binding site [chemical binding]; other site
459424011907	amidophosphoribosyltransferase; Provisional; Region: PRK07847
459424011908	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
459424011909	active site
459424011910	tetramer interface [polypeptide binding]; other site
459424011911	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
459424011912	active site
459424011913	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424011914	mce related protein; Region: MCE; pfam02470
459424011915	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424011916	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
459424011917	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
459424011918	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
459424011919	active site
459424011920	metal binding site [ion binding]; metal-binding site
459424011921	hexamer interface [polypeptide binding]; other site
459424011922	CAAX protease self-immunity; Region: Abi; pfam02517
459424011923	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
459424011924	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
459424011925	dimerization interface [polypeptide binding]; other site
459424011926	ATP binding site [chemical binding]; other site
459424011927	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
459424011928	dimerization interface [polypeptide binding]; other site
459424011929	ATP binding site [chemical binding]; other site
459424011930	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
459424011931	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
459424011932	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
459424011933	active site
459424011934	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424011935	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
459424011936	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
459424011937	active site
459424011938	metal binding site [ion binding]; metal-binding site
459424011939	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
459424011940	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
459424011941	Cupin domain; Region: Cupin_2; cl17218
459424011942	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
459424011943	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
459424011944	putative active site [active]
459424011945	catalytic triad [active]
459424011946	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
459424011947	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424011948	PPE family; Region: PPE; pfam00823
459424011949	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
459424011950	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
459424011951	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424011952	putative DNA binding site [nucleotide binding]; other site
459424011953	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
459424011954	putative Zn2+ binding site [ion binding]; other site
459424011955	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
459424011956	putative dimerization interface [polypeptide binding]; other site
459424011957	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
459424011958	Predicted deacetylase [General function prediction only]; Region: COG3233
459424011959	putative active site [active]
459424011960	putative Zn binding site [ion binding]; other site
459424011961	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424011962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424011963	putative substrate translocation pore; other site
459424011964	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424011965	Predicted membrane protein [Function unknown]; Region: COG4270
459424011966	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
459424011967	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
459424011968	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
459424011969	ATP binding site [chemical binding]; other site
459424011970	active site
459424011971	substrate binding site [chemical binding]; other site
459424011972	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
459424011973	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
459424011974	NAD binding site [chemical binding]; other site
459424011975	substrate binding site [chemical binding]; other site
459424011976	catalytic Zn binding site [ion binding]; other site
459424011977	tetramer interface [polypeptide binding]; other site
459424011978	structural Zn binding site [ion binding]; other site
459424011979	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
459424011980	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
459424011981	NAD(P) binding site [chemical binding]; other site
459424011982	catalytic residues [active]
459424011983	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
459424011984	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424011985	PPE family; Region: PPE; pfam00823
459424011986	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424011987	Cytochrome P450; Region: p450; cl12078
459424011988	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
459424011989	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
459424011990	tetramer interface [polypeptide binding]; other site
459424011991	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
459424011992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
459424011993	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
459424011994	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
459424011995	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011996	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424011997	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424011998	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424011999	Ligand Binding Site [chemical binding]; other site
459424012000	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424012001	Ligand Binding Site [chemical binding]; other site
459424012002	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
459424012003	Catalytic domain of Protein Kinases; Region: PKc; cd00180
459424012004	active site
459424012005	ATP binding site [chemical binding]; other site
459424012006	substrate binding site [chemical binding]; other site
459424012007	activation loop (A-loop); other site
459424012008	Protein of unknown function (DUF732); Region: DUF732; pfam05305
459424012009	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
459424012010	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
459424012011	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
459424012012	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
459424012013	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
459424012014	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
459424012015	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
459424012016	short chain dehydrogenase; Provisional; Region: PRK07774
459424012017	classical (c) SDRs; Region: SDR_c; cd05233
459424012018	NAD(P) binding site [chemical binding]; other site
459424012019	active site
459424012020	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
459424012021	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
459424012022	NAD binding site [chemical binding]; other site
459424012023	catalytic residues [active]
459424012024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424012025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424012026	short chain dehydrogenase; Provisional; Region: PRK07775
459424012027	classical (c) SDRs; Region: SDR_c; cd05233
459424012028	NAD(P) binding site [chemical binding]; other site
459424012029	active site
459424012030	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
459424012031	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
459424012032	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
459424012033	NAD binding site [chemical binding]; other site
459424012034	catalytic Zn binding site [ion binding]; other site
459424012035	substrate binding site [chemical binding]; other site
459424012036	structural Zn binding site [ion binding]; other site
459424012037	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
459424012038	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
459424012039	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
459424012040	nucleotide binding site/active site [active]
459424012041	HIT family signature motif; other site
459424012042	catalytic residue [active]
459424012043	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
459424012044	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424012045	dimerization interface [polypeptide binding]; other site
459424012046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
459424012047	dimer interface [polypeptide binding]; other site
459424012048	phosphorylation site [posttranslational modification]
459424012049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424012050	ATP binding site [chemical binding]; other site
459424012051	Mg2+ binding site [ion binding]; other site
459424012052	G-X-G motif; other site
459424012053	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424012054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424012055	active site
459424012056	phosphorylation site [posttranslational modification]
459424012057	intermolecular recognition site; other site
459424012058	dimerization interface [polypeptide binding]; other site
459424012059	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424012060	DNA binding site [nucleotide binding]
459424012061	salicylate hydroxylase; Provisional; Region: PRK08163
459424012062	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
459424012063	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
459424012064	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
459424012065	active site
459424012066	homotetramer interface [polypeptide binding]; other site
459424012067	putative OHCU decarboxylase; Provisional; Region: PRK13798
459424012068	xanthine permease; Region: pbuX; TIGR03173
459424012069	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
459424012070	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
459424012071	Sulfatase; Region: Sulfatase; pfam00884
459424012072	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
459424012073	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
459424012074	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
459424012075	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424012076	substrate binding site [chemical binding]; other site
459424012077	oxyanion hole (OAH) forming residues; other site
459424012078	trimer interface [polypeptide binding]; other site
459424012079	PE family; Region: PE; pfam00934
459424012080	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424012081	catalytic core [active]
459424012082	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
459424012083	Amidase; Region: Amidase; cl11426
459424012084	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
459424012085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424012086	putative substrate translocation pore; other site
459424012087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424012088	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
459424012089	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
459424012090	gating phenylalanine in ion channel; other site
459424012091	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
459424012092	Transcriptional regulator [Transcription]; Region: LytR; COG1316
459424012093	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
459424012094	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424012095	classical (c) SDRs; Region: SDR_c; cd05233
459424012096	NAD(P) binding site [chemical binding]; other site
459424012097	active site
459424012098	short chain dehydrogenase; Provisional; Region: PRK05875
459424012099	classical (c) SDRs; Region: SDR_c; cd05233
459424012100	NAD(P) binding site [chemical binding]; other site
459424012101	active site
459424012102	Phosphopantetheine attachment site; Region: PP-binding; cl09936
459424012103	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
459424012104	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424012105	catalytic residue [active]
459424012106	enoyl-CoA hydratase; Provisional; Region: PRK08290
459424012107	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424012108	substrate binding site [chemical binding]; other site
459424012109	oxyanion hole (OAH) forming residues; other site
459424012110	trimer interface [polypeptide binding]; other site
459424012111	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
459424012112	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
459424012113	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
459424012114	Walker A/P-loop; other site
459424012115	ATP binding site [chemical binding]; other site
459424012116	Q-loop/lid; other site
459424012117	ABC transporter signature motif; other site
459424012118	Walker B; other site
459424012119	D-loop; other site
459424012120	H-loop/switch region; other site
459424012121	Transport protein; Region: actII; TIGR00833
459424012122	Predicted transcriptional regulators [Transcription]; Region: COG1695
459424012123	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
459424012124	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
459424012125	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
459424012126	active site
459424012127	homotetramer interface [polypeptide binding]; other site
459424012128	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424012129	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
459424012130	mce related protein; Region: MCE; pfam02470
459424012131	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424012132	mce related protein; Region: MCE; pfam02470
459424012133	mce related protein; Region: MCE; pfam02470
459424012134	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424012135	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424012136	mce related protein; Region: MCE; pfam02470
459424012137	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424012138	mce related protein; Region: MCE; pfam02470
459424012139	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424012140	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
459424012141	mce related protein; Region: MCE; pfam02470
459424012142	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
459424012143	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
459424012144	Permease; Region: Permease; pfam02405
459424012145	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
459424012146	Permease; Region: Permease; pfam02405
459424012147	short chain dehydrogenase; Provisional; Region: PRK07791
459424012148	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424012149	NAD(P) binding site [chemical binding]; other site
459424012150	active site
459424012151	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
459424012152	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012153	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
459424012154	FAD binding site [chemical binding]; other site
459424012155	substrate binding site [chemical binding]; other site
459424012156	catalytic base [active]
459424012157	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012158	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424012159	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
459424012160	active site
459424012161	acyl-CoA synthetase; Validated; Region: PRK07867
459424012162	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
459424012163	acyl-activating enzyme (AAE) consensus motif; other site
459424012164	putative AMP binding site [chemical binding]; other site
459424012165	putative active site [active]
459424012166	putative CoA binding site [chemical binding]; other site
459424012167	hypothetical protein; Validated; Region: PRK07586
459424012168	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
459424012169	PYR/PP interface [polypeptide binding]; other site
459424012170	dimer interface [polypeptide binding]; other site
459424012171	TPP binding site [chemical binding]; other site
459424012172	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
459424012173	TPP-binding site [chemical binding]; other site
459424012174	dimer interface [polypeptide binding]; other site
459424012175	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
459424012176	acyl-CoA synthetase; Validated; Region: PRK07798
459424012177	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424012178	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
459424012179	acyl-activating enzyme (AAE) consensus motif; other site
459424012180	acyl-activating enzyme (AAE) consensus motif; other site
459424012181	putative AMP binding site [chemical binding]; other site
459424012182	putative active site [active]
459424012183	putative CoA binding site [chemical binding]; other site
459424012184	enoyl-CoA hydratase; Provisional; Region: PRK07799
459424012185	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424012186	substrate binding site [chemical binding]; other site
459424012187	oxyanion hole (OAH) forming residues; other site
459424012188	trimer interface [polypeptide binding]; other site
459424012189	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424012190	Cytochrome P450; Region: p450; cl12078
459424012191	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
459424012192	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
459424012193	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424012194	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
459424012195	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
459424012196	DUF35 OB-fold domain; Region: DUF35; pfam01796
459424012197	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
459424012198	DUF35 OB-fold domain; Region: DUF35; pfam01796
459424012199	lipid-transfer protein; Provisional; Region: PRK07937
459424012200	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424012201	active site
459424012202	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
459424012203	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424012204	active site
459424012205	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
459424012206	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424012207	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424012208	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424012209	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424012210	Uncharacterized conserved protein [Function unknown]; Region: COG3391
459424012211	NHL repeat; Region: NHL; pfam01436
459424012212	NHL repeat; Region: NHL; pfam01436
459424012213	NHL repeat; Region: NHL; pfam01436
459424012214	Uncharacterized conserved protein [Function unknown]; Region: COG3391
459424012215	NHL repeat; Region: NHL; pfam01436
459424012216	NHL repeat; Region: NHL; pfam01436
459424012217	PE family; Region: PE; pfam00934
459424012218	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
459424012219	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
459424012220	trimer interface [polypeptide binding]; other site
459424012221	putative metal binding site [ion binding]; other site
459424012222	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
459424012223	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
459424012224	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
459424012225	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
459424012226	short chain dehydrogenase; Provisional; Region: PRK07890
459424012227	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424012228	NAD(P) binding site [chemical binding]; other site
459424012229	active site
459424012230	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
459424012231	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
459424012232	active site
459424012233	catalytic residues [active]
459424012234	metal binding site [ion binding]; metal-binding site
459424012235	DmpG-like communication domain; Region: DmpG_comm; pfam07836
459424012236	acetaldehyde dehydrogenase; Validated; Region: PRK08300
459424012237	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
459424012238	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
459424012239	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
459424012240	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
459424012241	enoyl-CoA hydratase; Region: PLN02864
459424012242	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
459424012243	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
459424012244	dimer interaction site [polypeptide binding]; other site
459424012245	substrate-binding tunnel; other site
459424012246	active site
459424012247	catalytic site [active]
459424012248	substrate binding site [chemical binding]; other site
459424012249	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
459424012250	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
459424012251	putative active site [active]
459424012252	lipid-transfer protein; Provisional; Region: PRK07855
459424012253	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
459424012254	active site
459424012255	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
459424012256	putative active site [active]
459424012257	putative catalytic site [active]
459424012258	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
459424012259	active site
459424012260	catalytic site [active]
459424012261	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
459424012262	DUF35 OB-fold domain; Region: DUF35; pfam01796
459424012263	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012264	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012265	active site
459424012266	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012267	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424012268	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012269	active site
459424012270	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424012271	Cytochrome P450; Region: p450; cl12078
459424012272	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
459424012273	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424012274	dimer interface [polypeptide binding]; other site
459424012275	active site
459424012276	Domain of unknown function (DUF385); Region: DUF385; pfam04075
459424012277	short chain dehydrogenase; Provisional; Region: PRK07791
459424012278	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424012279	NAD(P) binding site [chemical binding]; other site
459424012280	active site
459424012281	short chain dehydrogenase; Provisional; Region: PRK07856
459424012282	classical (c) SDRs; Region: SDR_c; cd05233
459424012283	NAD(P) binding site [chemical binding]; other site
459424012284	active site
459424012285	PE family; Region: PE; pfam00934
459424012286	enoyl-CoA hydratase; Provisional; Region: PRK06495
459424012287	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
459424012288	substrate binding site [chemical binding]; other site
459424012289	oxyanion hole (OAH) forming residues; other site
459424012290	trimer interface [polypeptide binding]; other site
459424012291	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
459424012292	Coenzyme A transferase; Region: CoA_trans; cl17247
459424012293	Nitronate monooxygenase; Region: NMO; pfam03060
459424012294	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
459424012295	FMN binding site [chemical binding]; other site
459424012296	substrate binding site [chemical binding]; other site
459424012297	putative catalytic residue [active]
459424012298	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
459424012299	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
459424012300	putative di-iron ligands [ion binding]; other site
459424012301	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
459424012302	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
459424012303	FAD binding pocket [chemical binding]; other site
459424012304	FAD binding motif [chemical binding]; other site
459424012305	phosphate binding motif [ion binding]; other site
459424012306	beta-alpha-beta structure motif; other site
459424012307	NAD(p) ribose binding residues [chemical binding]; other site
459424012308	NAD binding pocket [chemical binding]; other site
459424012309	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
459424012310	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424012311	catalytic loop [active]
459424012312	iron binding site [ion binding]; other site
459424012313	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
459424012314	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
459424012315	dimer interface [polypeptide binding]; other site
459424012316	active site
459424012317	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424012318	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424012319	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
459424012320	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424012321	PPE family; Region: PPE; pfam00823
459424012322	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424012323	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
459424012324	short chain dehydrogenase; Provisional; Region: PRK07831
459424012325	classical (c) SDRs; Region: SDR_c; cd05233
459424012326	NAD(P) binding site [chemical binding]; other site
459424012327	active site
459424012328	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012329	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012330	active site
459424012331	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
459424012332	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424012333	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
459424012334	acyl-activating enzyme (AAE) consensus motif; other site
459424012335	acyl-activating enzyme (AAE) consensus motif; other site
459424012336	putative AMP binding site [chemical binding]; other site
459424012337	putative active site [active]
459424012338	putative CoA binding site [chemical binding]; other site
459424012339	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012340	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012341	active site
459424012342	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424012343	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012344	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012345	active site
459424012346	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
459424012347	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012348	aspartate aminotransferase; Provisional; Region: PRK05764
459424012349	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424012350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424012351	homodimer interface [polypeptide binding]; other site
459424012352	catalytic residue [active]
459424012353	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
459424012354	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
459424012355	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
459424012356	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
459424012357	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
459424012358	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
459424012359	Peptidase family M48; Region: Peptidase_M48; cl12018
459424012360	Penicillinase repressor; Region: Pencillinase_R; pfam03965
459424012361	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
459424012362	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
459424012363	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
459424012364	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
459424012365	active site
459424012366	Fe binding site [ion binding]; other site
459424012367	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
459424012368	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424012369	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
459424012370	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012371	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
459424012372	Flavin binding site [chemical binding]; other site
459424012373	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
459424012374	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
459424012375	FAD binding pocket [chemical binding]; other site
459424012376	FAD binding motif [chemical binding]; other site
459424012377	phosphate binding motif [ion binding]; other site
459424012378	beta-alpha-beta structure motif; other site
459424012379	NAD(p) ribose binding residues [chemical binding]; other site
459424012380	NAD binding pocket [chemical binding]; other site
459424012381	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
459424012382	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
459424012383	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
459424012384	catalytic loop [active]
459424012385	iron binding site [ion binding]; other site
459424012386	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012387	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
459424012388	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012389	active site
459424012390	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012391	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012392	active site
459424012393	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424012394	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424012395	Transcriptional regulators [Transcription]; Region: PurR; COG1609
459424012396	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
459424012397	DNA binding site [nucleotide binding]
459424012398	domain linker motif; other site
459424012399	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
459424012400	putative dimerization interface [polypeptide binding]; other site
459424012401	putative ligand binding site [chemical binding]; other site
459424012402	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
459424012403	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
459424012404	intersubunit interface [polypeptide binding]; other site
459424012405	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
459424012406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
459424012407	Walker A/P-loop; other site
459424012408	ATP binding site [chemical binding]; other site
459424012409	Q-loop/lid; other site
459424012410	ABC transporter signature motif; other site
459424012411	Walker B; other site
459424012412	D-loop; other site
459424012413	H-loop/switch region; other site
459424012414	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
459424012415	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
459424012416	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424012417	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424012418	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
459424012419	putative active site [active]
459424012420	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
459424012421	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
459424012422	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
459424012423	transmembrane helices; other site
459424012424	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
459424012425	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
459424012426	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
459424012427	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
459424012428	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
459424012429	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
459424012430	active site
459424012431	HIGH motif; other site
459424012432	nucleotide binding site [chemical binding]; other site
459424012433	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
459424012434	KMSKS motif; other site
459424012435	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
459424012436	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
459424012437	homotrimer interaction site [polypeptide binding]; other site
459424012438	zinc binding site [ion binding]; other site
459424012439	CDP-binding sites; other site
459424012440	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
459424012441	substrate binding site; other site
459424012442	dimer interface; other site
459424012443	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
459424012444	DNA repair protein RadA; Provisional; Region: PRK11823
459424012445	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
459424012446	Walker A motif; other site
459424012447	ATP binding site [chemical binding]; other site
459424012448	Walker B motif; other site
459424012449	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
459424012450	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
459424012451	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
459424012452	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
459424012453	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
459424012454	active site clefts [active]
459424012455	zinc binding site [ion binding]; other site
459424012456	dimer interface [polypeptide binding]; other site
459424012457	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
459424012458	endonuclease III; Region: ENDO3c; smart00478
459424012459	minor groove reading motif; other site
459424012460	helix-hairpin-helix signature motif; other site
459424012461	substrate binding pocket [chemical binding]; other site
459424012462	active site
459424012463	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
459424012464	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
459424012465	catalytic site [active]
459424012466	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
459424012467	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
459424012468	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
459424012469	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
459424012470	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
459424012471	Ligand binding site; other site
459424012472	Putative Catalytic site; other site
459424012473	DXD motif; other site
459424012474	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
459424012475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424012476	putative substrate translocation pore; other site
459424012477	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424012478	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424012479	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424012480	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424012481	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424012482	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424012483	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424012484	catalytic core [active]
459424012485	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
459424012486	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
459424012487	Clp amino terminal domain; Region: Clp_N; pfam02861
459424012488	Clp amino terminal domain; Region: Clp_N; pfam02861
459424012489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424012490	Walker A motif; other site
459424012491	ATP binding site [chemical binding]; other site
459424012492	Walker B motif; other site
459424012493	arginine finger; other site
459424012494	UvrB/uvrC motif; Region: UVR; pfam02151
459424012495	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424012496	Walker A motif; other site
459424012497	ATP binding site [chemical binding]; other site
459424012498	Walker B motif; other site
459424012499	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
459424012500	Lsr2; Region: Lsr2; pfam11774
459424012501	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
459424012502	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
459424012503	dimer interface [polypeptide binding]; other site
459424012504	putative anticodon binding site; other site
459424012505	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
459424012506	motif 1; other site
459424012507	dimer interface [polypeptide binding]; other site
459424012508	active site
459424012509	motif 2; other site
459424012510	motif 3; other site
459424012511	pantothenate kinase; Reviewed; Region: PRK13318
459424012512	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
459424012513	tetramerization interface [polypeptide binding]; other site
459424012514	active site
459424012515	Pantoate-beta-alanine ligase; Region: PanC; cd00560
459424012516	pantoate--beta-alanine ligase; Region: panC; TIGR00018
459424012517	active site
459424012518	ATP-binding site [chemical binding]; other site
459424012519	pantoate-binding site; other site
459424012520	HXXH motif; other site
459424012521	Uncharacterized conserved protein [Function unknown]; Region: COG5495
459424012522	Rossmann-like domain; Region: Rossmann-like; pfam10727
459424012523	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
459424012524	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
459424012525	catalytic center binding site [active]
459424012526	ATP binding site [chemical binding]; other site
459424012527	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
459424012528	homooctamer interface [polypeptide binding]; other site
459424012529	active site
459424012530	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
459424012531	substrate binding pocket [chemical binding]; other site
459424012532	dimer interface [polypeptide binding]; other site
459424012533	inhibitor binding site; inhibition site
459424012534	FtsH Extracellular; Region: FtsH_ext; pfam06480
459424012535	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
459424012536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424012537	Walker A motif; other site
459424012538	ATP binding site [chemical binding]; other site
459424012539	Walker B motif; other site
459424012540	arginine finger; other site
459424012541	Peptidase family M41; Region: Peptidase_M41; pfam01434
459424012542	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
459424012543	GTP cyclohydrolase I; Provisional; Region: PLN03044
459424012544	homodecamer interface [polypeptide binding]; other site
459424012545	active site
459424012546	putative catalytic site residues [active]
459424012547	zinc binding site [ion binding]; other site
459424012548	GTP-CH-I/GFRP interaction surface; other site
459424012549	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424012550	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
459424012551	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424012552	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
459424012553	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
459424012554	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
459424012555	putative NAD(P) binding site [chemical binding]; other site
459424012556	catalytic Zn binding site [ion binding]; other site
459424012557	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424012558	PPE family; Region: PPE; pfam00823
459424012559	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424012560	PE family; Region: PE; pfam00934
459424012561	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
459424012562	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
459424012563	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424012564	PPE family; Region: PPE; pfam00823
459424012565	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
459424012566	PE family; Region: PE; pfam00934
459424012567	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424012568	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424012569	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424012570	Uncharacterized conserved protein [Function unknown]; Region: COG2968
459424012571	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
459424012572	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
459424012573	active site
459424012574	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
459424012575	putative hydrolase; Region: TIGR03624
459424012576	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
459424012577	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
459424012578	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
459424012579	dimer interface [polypeptide binding]; other site
459424012580	substrate binding site [chemical binding]; other site
459424012581	metal binding sites [ion binding]; metal-binding site
459424012582	hypothetical protein; Provisional; Region: PRK14013
459424012583	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
459424012584	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
459424012585	Ligand binding site; other site
459424012586	Putative Catalytic site; other site
459424012587	DXD motif; other site
459424012588	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
459424012589	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
459424012590	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
459424012591	NAD(P) binding site [chemical binding]; other site
459424012592	active site
459424012593	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
459424012594	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
459424012595	Fic/DOC family; Region: Fic; cl00960
459424012596	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
459424012597	DNA polymerase III subunit delta'; Validated; Region: PRK07940
459424012598	DNA polymerase III subunit delta'; Validated; Region: PRK08485
459424012599	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
459424012600	dimerization interface [polypeptide binding]; other site
459424012601	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
459424012602	cyclase homology domain; Region: CHD; cd07302
459424012603	nucleotidyl binding site; other site
459424012604	metal binding site [ion binding]; metal-binding site
459424012605	dimer interface [polypeptide binding]; other site
459424012606	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
459424012607	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
459424012608	active site
459424012609	interdomain interaction site; other site
459424012610	putative metal-binding site [ion binding]; other site
459424012611	nucleotide binding site [chemical binding]; other site
459424012612	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
459424012613	domain I; other site
459424012614	phosphate binding site [ion binding]; other site
459424012615	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
459424012616	domain II; other site
459424012617	domain III; other site
459424012618	nucleotide binding site [chemical binding]; other site
459424012619	DNA binding groove [nucleotide binding]
459424012620	catalytic site [active]
459424012621	domain IV; other site
459424012622	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
459424012623	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
459424012624	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
459424012625	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
459424012626	DNA-binding site [nucleotide binding]; DNA binding site
459424012627	RNA-binding motif; other site
459424012628	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
459424012629	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
459424012630	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
459424012631	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
459424012632	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
459424012633	Walker A motif; other site
459424012634	ATP binding site [chemical binding]; other site
459424012635	Walker B motif; other site
459424012636	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
459424012637	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
459424012638	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
459424012639	motif II; other site
459424012640	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
459424012641	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
459424012642	Walker A/P-loop; other site
459424012643	ATP binding site [chemical binding]; other site
459424012644	Q-loop/lid; other site
459424012645	ABC transporter signature motif; other site
459424012646	Walker B; other site
459424012647	D-loop; other site
459424012648	H-loop/switch region; other site
459424012649	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
459424012650	Walker A/P-loop; other site
459424012651	ATP binding site [chemical binding]; other site
459424012652	Q-loop/lid; other site
459424012653	ABC transporter signature motif; other site
459424012654	Walker B; other site
459424012655	D-loop; other site
459424012656	H-loop/switch region; other site
459424012657	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
459424012658	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
459424012659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424012660	dimer interface [polypeptide binding]; other site
459424012661	conserved gate region; other site
459424012662	putative PBP binding loops; other site
459424012663	ABC-ATPase subunit interface; other site
459424012664	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
459424012665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424012666	dimer interface [polypeptide binding]; other site
459424012667	conserved gate region; other site
459424012668	ABC-ATPase subunit interface; other site
459424012669	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
459424012670	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
459424012671	acetyl-CoA synthetase; Provisional; Region: PRK00174
459424012672	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
459424012673	active site
459424012674	CoA binding site [chemical binding]; other site
459424012675	acyl-activating enzyme (AAE) consensus motif; other site
459424012676	AMP binding site [chemical binding]; other site
459424012677	acetate binding site [chemical binding]; other site
459424012678	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
459424012679	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
459424012680	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
459424012681	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
459424012682	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
459424012683	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
459424012684	putative active site [active]
459424012685	putative CoA binding site [chemical binding]; other site
459424012686	nudix motif; other site
459424012687	metal binding site [ion binding]; metal-binding site
459424012688	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
459424012689	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
459424012690	catalytic residues [active]
459424012691	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
459424012692	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
459424012693	minor groove reading motif; other site
459424012694	helix-hairpin-helix signature motif; other site
459424012695	substrate binding pocket [chemical binding]; other site
459424012696	active site
459424012697	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
459424012698	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
459424012699	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
459424012700	ligand binding site [chemical binding]; other site
459424012701	flexible hinge region; other site
459424012702	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
459424012703	putative switch regulator; other site
459424012704	non-specific DNA interactions [nucleotide binding]; other site
459424012705	DNA binding site [nucleotide binding]
459424012706	sequence specific DNA binding site [nucleotide binding]; other site
459424012707	putative cAMP binding site [chemical binding]; other site
459424012708	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
459424012709	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
459424012710	homotrimer interaction site [polypeptide binding]; other site
459424012711	putative active site [active]
459424012712	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
459424012713	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
459424012714	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
459424012715	P loop; other site
459424012716	Nucleotide binding site [chemical binding]; other site
459424012717	DTAP/Switch II; other site
459424012718	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
459424012719	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
459424012720	DTAP/Switch II; other site
459424012721	Switch I; other site
459424012722	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
459424012723	Transcription factor WhiB; Region: Whib; pfam02467
459424012724	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
459424012725	Transglycosylase; Region: Transgly; pfam00912
459424012726	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
459424012727	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
459424012728	phosphodiesterase YaeI; Provisional; Region: PRK11340
459424012729	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
459424012730	putative active site [active]
459424012731	putative metal binding site [ion binding]; other site
459424012732	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
459424012733	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
459424012734	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424012735	catalytic residue [active]
459424012736	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
459424012737	Cytochrome P450; Region: p450; cl12078
459424012738	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
459424012739	PAS fold; Region: PAS_3; pfam08447
459424012740	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
459424012741	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
459424012742	anti sigma factor interaction site; other site
459424012743	regulatory phosphorylation site [posttranslational modification]; other site
459424012744	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
459424012745	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
459424012746	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
459424012747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424012748	ATP binding site [chemical binding]; other site
459424012749	Mg2+ binding site [ion binding]; other site
459424012750	G-X-G motif; other site
459424012751	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
459424012752	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
459424012753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
459424012754	PAS domain; Region: PAS_9; pfam13426
459424012755	putative active site [active]
459424012756	heme pocket [chemical binding]; other site
459424012757	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
459424012758	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
459424012759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
459424012760	Domain of unknown function (DUF222); Region: DUF222; pfam02720
459424012761	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
459424012762	active site
459424012763	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
459424012764	intracellular protease, PfpI family; Region: PfpI; TIGR01382
459424012765	proposed catalytic triad [active]
459424012766	conserved cys residue [active]
459424012767	selenophosphate synthetase; Provisional; Region: PRK00943
459424012768	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
459424012769	dimerization interface [polypeptide binding]; other site
459424012770	putative ATP binding site [chemical binding]; other site
459424012771	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
459424012772	G1 box; other site
459424012773	putative GEF interaction site [polypeptide binding]; other site
459424012774	GTP/Mg2+ binding site [chemical binding]; other site
459424012775	Switch I region; other site
459424012776	G2 box; other site
459424012777	G3 box; other site
459424012778	Switch II region; other site
459424012779	G4 box; other site
459424012780	G5 box; other site
459424012781	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
459424012782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424012783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
459424012784	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424012785	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424012786	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
459424012787	4Fe-4S binding domain; Region: Fer4_6; pfam12837
459424012788	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
459424012789	Uncharacterized conserved protein [Function unknown]; Region: COG1610
459424012790	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
459424012791	MoxR-like ATPases [General function prediction only]; Region: COG0714
459424012792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424012793	Walker A motif; other site
459424012794	ATP binding site [chemical binding]; other site
459424012795	Walker B motif; other site
459424012796	arginine finger; other site
459424012797	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
459424012798	Protein of unknown function DUF58; Region: DUF58; pfam01882
459424012799	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
459424012800	Predicted membrane protein/domain [Function unknown]; Region: COG1714
459424012801	Predicted transcriptional regulators [Transcription]; Region: COG1695
459424012802	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
459424012803	PE family; Region: PE; pfam00934
459424012804	glycerol kinase; Provisional; Region: glpK; PRK00047
459424012805	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
459424012806	N- and C-terminal domain interface [polypeptide binding]; other site
459424012807	active site
459424012808	MgATP binding site [chemical binding]; other site
459424012809	catalytic site [active]
459424012810	metal binding site [ion binding]; metal-binding site
459424012811	putative homotetramer interface [polypeptide binding]; other site
459424012812	glycerol binding site [chemical binding]; other site
459424012813	homodimer interface [polypeptide binding]; other site
459424012814	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
459424012815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424012816	S-adenosylmethionine binding site [chemical binding]; other site
459424012817	ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343
459424012818	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
459424012819	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424012820	catalytic residue [active]
459424012821	Uncharacterized conserved protein [Function unknown]; Region: COG4301
459424012822	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
459424012823	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
459424012824	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
459424012825	putative active site [active]
459424012826	putative dimer interface [polypeptide binding]; other site
459424012827	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
459424012828	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
459424012829	ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444
459424012830	PknH-like extracellular domain; Region: PknH_C; pfam14032
459424012831	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
459424012832	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
459424012833	tetramer interface [polypeptide binding]; other site
459424012834	heme binding pocket [chemical binding]; other site
459424012835	NADPH binding site [chemical binding]; other site
459424012836	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
459424012837	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
459424012838	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
459424012839	aspartate kinase; Reviewed; Region: PRK06635
459424012840	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
459424012841	putative nucleotide binding site [chemical binding]; other site
459424012842	putative catalytic residues [active]
459424012843	putative Mg ion binding site [ion binding]; other site
459424012844	putative aspartate binding site [chemical binding]; other site
459424012845	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
459424012846	putative allosteric regulatory site; other site
459424012847	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
459424012848	putative allosteric regulatory residue; other site
459424012849	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424012850	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424012851	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424012852	2-isopropylmalate synthase; Validated; Region: PRK03739
459424012853	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
459424012854	active site
459424012855	catalytic residues [active]
459424012856	metal binding site [ion binding]; metal-binding site
459424012857	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
459424012858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
459424012859	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
459424012860	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
459424012861	active site
459424012862	catalytic site [active]
459424012863	substrate binding site [chemical binding]; other site
459424012864	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
459424012865	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
459424012866	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
459424012867	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
459424012868	catalytic triad [active]
459424012869	recombination protein RecR; Reviewed; Region: recR; PRK00076
459424012870	RecR protein; Region: RecR; pfam02132
459424012871	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
459424012872	putative active site [active]
459424012873	putative metal-binding site [ion binding]; other site
459424012874	tetramer interface [polypeptide binding]; other site
459424012875	hypothetical protein; Validated; Region: PRK00153
459424012876	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
459424012877	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
459424012878	active site
459424012879	metal binding site [ion binding]; metal-binding site
459424012880	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
459424012881	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
459424012882	FAD binding domain; Region: FAD_binding_4; pfam01565
459424012883	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
459424012884	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
459424012885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
459424012886	S-adenosylmethionine binding site [chemical binding]; other site
459424012887	RDD family; Region: RDD; pfam06271
459424012888	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
459424012889	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
459424012890	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424012891	catalytic residue [active]
459424012892	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
459424012893	CHAT domain; Region: CHAT; cl17868
459424012894	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424012895	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
459424012896	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
459424012897	active site
459424012898	phosphorylation site [posttranslational modification]
459424012899	intermolecular recognition site; other site
459424012900	dimerization interface [polypeptide binding]; other site
459424012901	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
459424012902	DNA binding site [nucleotide binding]
459424012903	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
459424012904	dimer interface [polypeptide binding]; other site
459424012905	phosphorylation site [posttranslational modification]
459424012906	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
459424012907	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
459424012908	ATP binding site [chemical binding]; other site
459424012909	Mg2+ binding site [ion binding]; other site
459424012910	G-X-G motif; other site
459424012911	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
459424012912	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
459424012913	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
459424012914	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
459424012915	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
459424012916	NAD(P) binding site [chemical binding]; other site
459424012917	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424012918	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424012919	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
459424012920	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
459424012921	active site
459424012922	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
459424012923	classical (c) SDRs; Region: SDR_c; cd05233
459424012924	NAD(P) binding site [chemical binding]; other site
459424012925	active site
459424012926	PE family; Region: PE; pfam00934
459424012927	PE family; Region: PE; pfam00934
459424012928	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424012929	catalytic core [active]
459424012930	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
459424012931	putative active site [active]
459424012932	ATP binding site [chemical binding]; other site
459424012933	putative substrate binding site [chemical binding]; other site
459424012934	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424012935	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424012936	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424012937	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
459424012938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
459424012939	ABC-ATPase subunit interface; other site
459424012940	Putative glycolipid-binding; Region: Glycolipid_bind; cl01425
459424012941	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
459424012942	prephenate dehydrogenase; Validated; Region: PRK08507
459424012943	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
459424012944	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
459424012945	nucleoside/Zn binding site; other site
459424012946	dimer interface [polypeptide binding]; other site
459424012947	catalytic motif [active]
459424012948	PE family; Region: PE; pfam00934
459424012949	Uncharacterized conserved protein [Function unknown]; Region: COG0393
459424012950	TM2 domain; Region: TM2; pfam05154
459424012951	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424012952	classical (c) SDRs; Region: SDR_c; cd05233
459424012953	NAD(P) binding site [chemical binding]; other site
459424012954	active site
459424012955	PE family; Region: PE; pfam00934
459424012956	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
459424012957	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
459424012958	Zn binding site [ion binding]; other site
459424012959	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
459424012960	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
459424012961	acyl-activating enzyme (AAE) consensus motif; other site
459424012962	AMP binding site [chemical binding]; other site
459424012963	active site
459424012964	CoA binding site [chemical binding]; other site
459424012965	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
459424012966	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
459424012967	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
459424012968	putative trimer interface [polypeptide binding]; other site
459424012969	putative CoA binding site [chemical binding]; other site
459424012970	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
459424012971	putative trimer interface [polypeptide binding]; other site
459424012972	putative CoA binding site [chemical binding]; other site
459424012973	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
459424012974	dimerization interface [polypeptide binding]; other site
459424012975	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
459424012976	NAD binding site [chemical binding]; other site
459424012977	ligand binding site [chemical binding]; other site
459424012978	catalytic site [active]
459424012979	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
459424012980	classical (c) SDRs; Region: SDR_c; cd05233
459424012981	NAD(P) binding site [chemical binding]; other site
459424012982	active site
459424012983	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
459424012984	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
459424012985	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424012986	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
459424012987	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
459424012988	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
459424012989	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
459424012990	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
459424012991	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
459424012992	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
459424012993	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
459424012994	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
459424012995	acyl-activating enzyme (AAE) consensus motif; other site
459424012996	putative AMP binding site [chemical binding]; other site
459424012997	putative active site [active]
459424012998	putative CoA binding site [chemical binding]; other site
459424012999	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
459424013000	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013001	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013002	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424013003	PE family; Region: PE; pfam00934
459424013004	SnoaL-like domain; Region: SnoaL_2; pfam12680
459424013005	Phosphotransferase enzyme family; Region: APH; pfam01636
459424013006	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
459424013007	putative active site [active]
459424013008	putative substrate binding site [chemical binding]; other site
459424013009	ATP binding site [chemical binding]; other site
459424013010	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
459424013011	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
459424013012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
459424013013	homodimer interface [polypeptide binding]; other site
459424013014	catalytic residue [active]
459424013015	GXWXG protein; Region: GXWXG; pfam14231
459424013016	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
459424013017	TIGR03086 family protein; Region: TIGR03086
459424013018	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
459424013019	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424013020	PPE family; Region: PPE; pfam00823
459424013021	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
459424013022	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
459424013023	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
459424013024	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
459424013025	NAD(P) binding site [chemical binding]; other site
459424013026	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
459424013027	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
459424013028	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
459424013029	catalytic residue [active]
459424013030	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
459424013031	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
459424013032	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
459424013033	Walker A/P-loop; other site
459424013034	ATP binding site [chemical binding]; other site
459424013035	Q-loop/lid; other site
459424013036	ABC transporter signature motif; other site
459424013037	Walker B; other site
459424013038	D-loop; other site
459424013039	H-loop/switch region; other site
459424013040	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
459424013041	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
459424013042	active site
459424013043	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
459424013044	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
459424013045	PE family; Region: PE; pfam00934
459424013046	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
459424013047	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
459424013048	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
459424013049	dimerization interface [polypeptide binding]; other site
459424013050	putative DNA binding site [nucleotide binding]; other site
459424013051	putative Zn2+ binding site [ion binding]; other site
459424013052	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
459424013053	active site
459424013054	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013055	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013056	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013057	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
459424013058	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
459424013059	active site
459424013060	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
459424013061	Peptidase family M23; Region: Peptidase_M23; pfam01551
459424013062	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
459424013063	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424013064	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013065	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
459424013067	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
459424013068	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
459424013069	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
459424013070	Predicted membrane protein [Function unknown]; Region: COG2246
459424013071	GtrA-like protein; Region: GtrA; pfam04138
459424013072	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
459424013073	FAD binding domain; Region: FAD_binding_4; pfam01565
459424013074	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
459424013075	short chain dehydrogenase; Provisional; Region: PRK07904
459424013076	short chain dehydrogenase; Provisional; Region: PRK06101
459424013077	NAD(P) binding site [chemical binding]; other site
459424013078	active site
459424013079	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
459424013080	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
459424013081	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
459424013082	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
459424013083	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
459424013084	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
459424013085	PE family; Region: PE; pfam00934
459424013086	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
459424013087	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
459424013088	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
459424013089	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424013090	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
459424013091	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
459424013092	active site
459424013093	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
459424013094	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
459424013095	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
459424013096	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
459424013097	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
459424013098	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
459424013099	acyl-activating enzyme (AAE) consensus motif; other site
459424013100	active site
459424013101	Cutinase; Region: Cutinase; pfam01083
459424013102	Predicted esterase [General function prediction only]; Region: COG0627
459424013103	Putative esterase; Region: Esterase; pfam00756
459424013104	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
459424013105	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
459424013106	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
459424013107	active site
459424013108	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
459424013109	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
459424013110	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424013111	UDP-galactopyranose mutase; Region: GLF; pfam03275
459424013112	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
459424013113	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
459424013114	substrate binding site [chemical binding]; other site
459424013115	amidase catalytic site [active]
459424013116	Zn binding residues [ion binding]; other site
459424013117	LGFP repeat; Region: LGFP; pfam08310
459424013118	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
459424013119	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
459424013120	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424013121	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
459424013122	putative acyl-acceptor binding pocket; other site
459424013123	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424013124	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
459424013125	putative acyl-acceptor binding pocket; other site
459424013126	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
459424013127	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
459424013128	putative acyl-acceptor binding pocket; other site
459424013129	Phosphotransferase enzyme family; Region: APH; pfam01636
459424013130	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
459424013131	active site
459424013132	ATP binding site [chemical binding]; other site
459424013133	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
459424013134	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
459424013135	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
459424013136	iron-sulfur cluster [ion binding]; other site
459424013137	[2Fe-2S] cluster binding site [ion binding]; other site
459424013138	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
459424013139	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424013140	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
459424013141	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424013142	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
459424013143	seryl-tRNA synthetase; Provisional; Region: PRK05431
459424013144	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
459424013145	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
459424013146	dimer interface [polypeptide binding]; other site
459424013147	active site
459424013148	motif 1; other site
459424013149	motif 2; other site
459424013150	motif 3; other site
459424013151	Septum formation; Region: Septum_form; pfam13845
459424013152	Septum formation; Region: Septum_form; pfam13845
459424013153	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
459424013154	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
459424013155	catalytic core [active]
459424013156	prephenate dehydratase; Provisional; Region: PRK11898
459424013157	Prephenate dehydratase; Region: PDT; pfam00800
459424013158	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
459424013159	putative L-Phe binding site [chemical binding]; other site
459424013160	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
459424013161	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
459424013162	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
459424013163	Ferritin-like domain; Region: Ferritin; pfam00210
459424013164	ferroxidase diiron center [ion binding]; other site
459424013165	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
459424013166	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
459424013167	putative active site [active]
459424013168	catalytic site [active]
459424013169	putative metal binding site [ion binding]; other site
459424013170	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
459424013171	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
459424013172	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
459424013173	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
459424013174	Predicted membrane protein [Function unknown]; Region: COG2119
459424013175	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
459424013176	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
459424013177	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
459424013178	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
459424013179	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
459424013180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424013181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
459424013182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
459424013183	hypothetical protein; Provisional; Region: PRK07945
459424013184	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
459424013185	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
459424013186	active site
459424013187	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
459424013188	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424013189	Ligand Binding Site [chemical binding]; other site
459424013190	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
459424013191	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
459424013192	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
459424013193	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
459424013194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
459424013195	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
459424013196	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
459424013197	active site
459424013198	dimer interface [polypeptide binding]; other site
459424013199	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
459424013200	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
459424013201	active site
459424013202	FMN binding site [chemical binding]; other site
459424013203	substrate binding site [chemical binding]; other site
459424013204	3Fe-4S cluster binding site [ion binding]; other site
459424013205	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
459424013206	domain interface; other site
459424013207	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424013208	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013209	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013210	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
459424013211	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
459424013212	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
459424013213	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
459424013214	EspG family; Region: ESX-1_EspG; pfam14011
459424013215	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
459424013216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
459424013217	Walker A motif; other site
459424013218	ATP binding site [chemical binding]; other site
459424013219	Walker B motif; other site
459424013220	arginine finger; other site
459424013221	Protein of unknown function (DUF690); Region: DUF690; pfam05108
459424013222	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
459424013223	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424013224	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
459424013225	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424013226	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
459424013227	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013228	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013229	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013230	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
459424013231	PPE family; Region: PPE; pfam00823
459424013232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
459424013233	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
459424013234	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424013235	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013236	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013237	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
459424013238	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
459424013239	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
459424013240	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
459424013241	active site
459424013242	catalytic residues [active]
459424013243	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
459424013244	N-acetyl-D-glucosamine binding site [chemical binding]; other site
459424013245	catalytic residue [active]
459424013246	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424013247	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013248	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013249	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
459424013250	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424013251	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013252	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013253	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
459424013254	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
459424013255	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
459424013256	Int/Topo IB signature motif; other site
459424013257	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
459424013258	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
459424013259	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
459424013260	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
459424013261	Protein of unknown function (DUF2563); Region: DUF2563; pfam10817
459424013262	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
459424013263	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
459424013264	active site
459424013265	NTP binding site [chemical binding]; other site
459424013266	metal binding triad [ion binding]; metal-binding site
459424013267	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
459424013268	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
459424013269	Zn2+ binding site [ion binding]; other site
459424013270	Mg2+ binding site [ion binding]; other site
459424013271	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
459424013272	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
459424013273	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
459424013274	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
459424013275	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
459424013276	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
459424013277	DNA binding residues [nucleotide binding]
459424013278	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
459424013279	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
459424013280	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
459424013281	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
459424013282	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
459424013283	catalytic residues [active]
459424013284	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
459424013285	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
459424013286	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
459424013287	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
459424013288	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
459424013289	active site
459424013290	metal binding site [ion binding]; metal-binding site
459424013291	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
459424013292	ParB-like nuclease domain; Region: ParB; smart00470
459424013293	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
459424013294	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
459424013295	P-loop; other site
459424013296	Magnesium ion binding site [ion binding]; other site
459424013297	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
459424013298	Magnesium ion binding site [ion binding]; other site
459424013299	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
459424013300	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
459424013301	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
459424013302	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
459424013303	G-X-X-G motif; other site
459424013304	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
459424013305	RxxxH motif; other site
459424013306	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
459424013307	hypothetical protein; Validated; Region: PRK00041