-- dump date 20140619_153120 -- class Genbank::CDS -- table cds_note -- id note YP_001840830.1 similar to AA sequence INSD:AY056023 YP_001840837.1 cleaves the carbon-mercury bond of organomercuric compounds YP_001840838.1 Contains four transmembrane domains. YP_001840840.1 Proposed that MerR binds to inverted repeat and represses transcription of merA in the absence of mercuric ions and negatively regulates its own expression in the presence of mercuric ions. YP_001840852.1 contains two transmembrane domains and a potential signal peptide sequence YP_001848327.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001848328.1 binds the polymerase to DNA and acts as a sliding clamp YP_001848329.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001848331.1 negatively supercoils closed circular double-stranded DNA YP_001848332.1 negatively supercoils closed circular double-stranded DNA YP_001848335.1 transcription YP_001848337.1 ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides] YP_001848339.1 integral membrane protein involved in inhibition of the Z-ring formation YP_001848341.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_001848342.1 involved in signal transduction (via phosphorylation). thought to regulate cell division/differentiation. can phosphorylate the peptide substrate myelin basic protein (MBP) [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001848343.1 involved in signal transduction (via phosphorylation). thought to regulate morphological changes associated with cell division/differentiation process. phosphorylates at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001848344.1 involved in peptidoglycan synthesis (at the final stages). cell wall formation; PbpA is supposed to be responsible for the determination of the rod shape of the cell. its synthesizes cross-linked peptidoglycan from lipid intermediates YP_001848345.1 this is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. plays a role in the stabilization of the FtsZ ring during cell division YP_001848346.1 involved in regulation (using dephosphorylation of a specific phosphorylated substrate) YP_001848348.1 function unknown, contains FHA domain YP_001848349.1 some domain conservation with a putative killer suppression protein HigA, from Methylococcus capsulatus str. Bath YP_001848350.1 antidote for potential plasmid segregant killing system. maybe the partner for the toxin encoded by the upstream gene YP_001848353.1 involved in deoxyribonucleotide biosynthesis. provides the sole de novo source of dTMP for dana biosynthesis [catalytic activity: 5,10- methylenetetrahydrofolate + dump = dihydrofolate + dTMP] YP_001848360.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for energy coupling to the transport system YP_001848361.1 maybe involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001848364.1 thought to be involved in transport of ammonium across the membrane (export). responsible for the translocation of the substrate across the membrane YP_001848366.1 N-term truncated by frame-shift mutation YP_001848367.1 involved in transcriptional mechanism YP_001848368.1 maybe involved in transcriptional mechanism YP_001848369.1 function unknown. the P60 protein is a major extracellular protein may be involved in the invasion of host cells YP_001848383.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001848384.1 function unknown, possibly involved in cellular metabolism YP_001848385.1 possibly involved in transcriptional mechanism YP_001848386.1 involved in amino acid transport and metabolism YP_001848387.1 amino acid transport and metabolism YP_001848388.1 involved in transcriptional mechanism YP_001848389.1 function unknown, probably involved in cellular metabolism YP_001848390.1 function unknown, probably involved in lipid biosynthesis YP_001848391.1 involved in phosphatidylinositol (pi) biosynthetic pathway [catalytic activity: d-glucose 6-phosphate = 1L- myo-inositol 1-phosphate] YP_001848395.1 involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) YP_001848398.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001848399.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_001848400.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001848401.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001848402.1 participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity YP_001848406.1 involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001848407.1 function unknown; probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001848408.1 involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001848410.1 function unknown; probably involved in cellular metabolism YP_001848411.1 contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription YP_001848412.1 function unknown, possibly involved in cellular metabolism YP_001848413.1 Contains a non-ribosomal peptide synthetase-like condensation domain YP_001848415.1 function unknown; contains thiopurine S- methyltransferase domain. this is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds YP_001848416.1 transposition of the insertion sequence, ISMyma01 YP_001848417.1 transposition of the insertion sequence, ISMyma01 YP_001848419.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001848420.1 thought to be involved in fatty acid transport YP_001848423.1 function unknown; many of the members of this family are found in known antibiotic synthesis gene clusters YP_001848424.1 polyketide synthase possibly involved in lipid synthesis YP_001848425.1 function unknown but the gene encodes a Nrp of three functional domains with the predicted sequential condensation of the amino acids threonine, threonine and alanine. the second domain contains an epimerization domain and the third domains contains a terminal te YP_001848427.1 function unknown but contains a single extension module with domain structure (KS, Ata, DH, KR, ACP) YP_001848428.1 function unknown but contains a single extension module with domain structure (KS, ATP, DH, ER, ACP) YP_001848430.1 function unknown but probable role in the production of unknown PKS/NRP metabolite from this locus. amino acid homology suggests this gene product may have fatty acid ligase activity YP_001848432.1 contains two MaoC acyl dehydratase domains YP_001848433.1 hydrolysis of cellobiose YP_001848434.1 involved in transcriptional mechanism YP_001848436.1 function unknown; probably involved in cellular metabolism YP_001848438.1 catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide YP_001848444.1 function unknown but some domain identity with nitroreductase-related proteins YP_001848445.1 function unknown but contains C-term predicted ATPase domain (AAA+ superfamily) YP_001848446.1 decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [catalytic activity: formate + NAD(+) = CO(2) + NADH] YP_001848447.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001848448.1 involved in transcriptional mechanism YP_001848449.1 possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone] YP_001848452.1 thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH] YP_001848453.1 function unknown; may be involved in electron transfer YP_001848454.1 function unknown, but the MmoB/DmpM family consists of monooxygenase components such as MmoB methane monooxygenase regulatory protein B. When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilises intermediates required for the activation of dioxygen YP_001848455.1 function unknown, but enzymes in this family are involved in hydroxylation of hydrocarbons YP_001848456.1 Enzymes in this family are involved in hydroxylation of hydrocarbons YP_001848457.1 response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain YP_001848458.1 sensor part of the two-component regulatory system YP_001848464.1 function unknown, but involved in lipid degradation YP_001848466.1 involved in transcriptional mechanism YP_001848467.1 possibly catalyzes the transfer of a great variety of lipids between membranes YP_001848472.1 function unknown YP_001848473.1 function unknown, glycosyltransferases, related to UDP-glucuronosyltransferase YP_001848474.1 function unknown, but involved in lipid degradation [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF] YP_001848475.1 involved in transcriptional mechanism YP_001848476.1 supposed involved in intracellular survival. possibly associated with the cell surface and secreted YP_001848479.1 function unknown, probably involved in cellular metabolism YP_001848480.1 function unknown, but possibly involvement in lipid degradation YP_001848481.1 function unknown, but involved in lipid degradation YP_001848482.1 possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate] YP_001848483.1 involved in the krebs cycle [catalytic activity: isocitrate + NADP+ = 2-oxoglutarate + CO(2) + NADPH] YP_001848485.1 function unknown. possibly secreted YP_001848489.1 function unknown, probably involved in cellular metabolism YP_001848490.1 function unknown YP_001848492.1 catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)] YP_001848496.1 probably involved in active transport of substrate across the membrane (export). responsible for energy coupling to the transport system YP_001848498.1 thought to be involved in de novo fatty acid biosynthesis; this protein is the carrier of the growing fatty acid chain in fatty acid biosynthesis YP_001848499.1 activates fatty acids by binding to coenzyme A YP_001848502.1 function unknown, but thought to be involved in host cell invasion YP_001848503.1 function unknown, but thought to be involved in host cell invasion YP_001848504.1 function unknown, but thought to be involved in host cell invasion YP_001848505.1 function unknown, but thought to be involved in host cell invasion YP_001848506.1 function unknown, but thought to be involved in host cell invasion YP_001848507.1 function unknown, but thought involved in host cell invasion YP_001848512.1 a culture filtrate antigen that forms part of a novel secretion apparatus YP_001848513.1 6kDA, culture filtrate antigen forms part of a novel secretion apparatus YP_001848514.1 function unknown but identity with other Esx proteins, including EsxA YP_001848529.1 function unknown, probably involved in cellular metabolism YP_001848530.1 involved in gluconeogenesis from serine [catalytic activity: L-serine + H2O = pyruvate + NH3 + H2O] YP_001848531.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001848532.1 the glycine cleavage system catalyses the degradation of glycine. the H protein shuttles the methylamine group of glycine from the P protein to the T protein YP_001848533.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001848534.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001848536.1 function unknown; involved in cellular metabolism YP_001848537.1 hydrolizes specific D-amino acid YP_001848538.1 function unknown. domain identity suggests anti- anti-sigma regulatory factor YP_001848539.1 involved in active transport of glutamine across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001848540.1 involved in active transport of glutamine across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001848546.1 involved in transcriptional mechanism YP_001848547.1 function unknown, probably involved in cellular metabolism YP_001848548.1 possibly involved in transcriptional mechanism YP_001848552.1 function unknown. contains HTH motif. may be involved in transcription regulation YP_001848554.1 function unknown, involved in cellular metabolism YP_001848555.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)] YP_001848557.1 contains copper chaperone domain YP_001848560.1 function unknown. possibly involved in cellular metabolism YP_001848561.1 involved in transcriptional mechanism YP_001848562.1 involved in transcriptional mechanism YP_001848563.1 function unknown; probably involved in cellular metabolism YP_001848564.1 function unknown, involved in cellular metabolism YP_001848565.1 function unknown, generates an aldehyde (or perhaps a ketone) from an alcohol YP_001848567.1 function unknown, possibly involved in cellular metabolism YP_001848568.1 thought to cause methylation YP_001848569.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001848572.1 function unknown, possibly involved in cellular metabolism YP_001848573.1 possibly involved in transcriptional mechanism YP_001848575.1 responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and s- adenosylhomocysteine (sah) [catalytic activity 1: methylthioadenosine + H2O = adenine + 5-methylthio-D- ribose] [catalytic activity 2: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine] YP_001848577.1 function unknown, but possibly involvement in lipid metabolism YP_001848578.1 thought to be involved in fatty acid transport YP_001848579.1 involved in lipid metabolism YP_001848581.1 activates fatty acids by binding to coenzyme A YP_001848583.1 function unknown, probably involved in cellular metabolism YP_001848585.1 function unknown, but supposed involved in lipid metabolism YP_001848587.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)] YP_001848588.1 involved in promoter recognition, transcription initiation YP_001848592.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly coopper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + orthophosphate + cation(out)] YP_001848593.1 function unknown, probably involved in cellular metabolism YP_001848594.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001848595.1 function unknown role in cellular metabolism YP_001848596.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001848597.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001848598.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001848599.1 LytB is involved in the trunk line of the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis YP_001848602.1 involved in isoprenoid biosynthesis. enzymes in this class catalyze the ionization of farnesyl diphosphate, followed by the formation of a macrocyclic intermediate by bond formation between C1 with either C10 (aristolochene synthase) or C11 (pentalenene synthase), resulting in production of tricyclic hydrocarbon pentalenene or bicyclic hydrocarbon aristolochene YP_001848603.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. some have been shown to bind tightly to a range of azole-based antifungal drugs (E.G. miconazole, clotrimazole) YP_001848604.1 involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths YP_001848605.1 cytochrome P450 are a group of heme-thiolate monooxygenases. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001848606.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate] YP_001848608.1 function unknown, probably involved in cellular metabolism YP_001848609.1 involved in transcriptional mechanism YP_001848611.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001848612.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001848613.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001848614.1 involved in ribosome activity YP_001848616.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001848617.1 function unknown; supposed involved in cellular metabolism YP_001848618.1 activates fatty acids by binding to coenzyme A YP_001848619.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly magnesium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)] YP_001848624.1 function unknown, possibly involved in cellular metabolism YP_001848626.1 involved in transcriptional mechanism YP_001848628.1 function unknown; possibly involved in cellular metabolism YP_001848629.1 function unknown; involved in cellular metabolism YP_001848630.1 function unknown, probably involved in cellular metabolism YP_001848631.1 function unknown, probably involved in cellular metabolism YP_001848632.1 function unknown, possibly involved in cellular metabolism YP_001848633.1 function unknown. possibly involved in energy production and conversion YP_001848634.1 function unknown, probably involved in cellular metabolism YP_001848635.1 thought to be involved in transfer of methyl group YP_001848637.1 H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane YP_001848639.1 could effect functions of OxyR during evolution YP_001848640.1 catalyzes the formation of formyl-CoA from oxalyl-CoA YP_001848641.1 activates fatty acids by binding to coenzyme A YP_001848643.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001848645.1 maybe involved in oxidization of aromatic hydrocarbons YP_001848646.1 function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues) YP_001848647.1 involved in trehalose biosynthesis (protective effect). converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) YP_001848650.1 proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity YP_001848653.1 function unknown, but involved in lipid degradation YP_001848654.1 function unknown, probably involved in cellular metabolism YP_001848656.1 involved in transcriptional mechanism YP_001848657.1 function unknown, contains flavodoxin reductases (ferredoxin-NADPH reductases) family 1 domain. [energy production and conversion] YP_001848658.1 thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O] YP_001848660.1 function unknown, probably involved in cellular metabolism YP_001848662.1 involved in transcriptional mechanism YP_001848664.1 thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol] YP_001848665.1 oxido-reduction YP_001848667.1 could be involved in transcriptional mechanism YP_001848668.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001848669.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_001848671.1 function unknown, probably involved in cellular metabolism YP_001848675.1 function unknown; possibly ion channel involved in transport of chloride across the membrane YP_001848677.1 involved in transcriptional mechanism YP_001848681.1 function unknown, probably involved in cellular metabolism [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH] YP_001848682.1 function unknown, possibly involved in cellular metabolism YP_001848683.1 possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone] YP_001848687.1 involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001848688.1 involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001848689.1 function unknown; probably involved in lipid metabolism YP_001848690.1 function unknown but contains 3 modules for the potential synthesis of a tripeptide YP_001848695.1 involved in signal transduction (via dephosphorylation). can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0. could be involved in virulence by interfering with phosphotyrosine-mediated signals in macrophages [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate] YP_001848696.1 function unknown, but involved in lipid degradation YP_001848699.1 the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH] YP_001848700.1 the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH] YP_001848701.1 the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH] YP_001848703.1 involved in transcriptional mechanism YP_001848709.1 thought to be involved in lipid biosynthesis [catalytic activity: androstan-3-alpha,17- beta-diol + NAD+ = 17-beta-hydroxyandrostan-3-one + NADH] YP_001848710.1 function unknown, probably involved in cellular metabolism YP_001848711.1 function unknown. contains TetR_N, bacterial regulatory proteins, TetR family domain. possibly involved in transcriptional mechanism YP_001848721.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001848722.1 function unknown; probably involved in cellular metabolism YP_001848725.1 function unknown, probably involved in cellular metabolism YP_001848726.1 function unknown, lipolytic enzyme probably involved in cellular metabolism YP_001848727.1 dehydrogeneses a alcohol (oxido-reduction) [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH] YP_001848730.1 possibly involved in transcriptional mechanism YP_001848731.1 function unknown, but involved in lipid degradation YP_001848734.1 function unknown, but thought to be involved in host cell invasion (entry and survival inside macrophages) YP_001848735.1 function unknown, but thought to be involved in host cell invasion YP_001848736.1 function unknown, but thought to be involved in host cell invasion YP_001848737.1 function unknown, but thought to be involved in host cell invasion YP_001848738.1 function unknown, but thought to be involved in host cell invasion YP_001848739.1 function unknown, but thought involved in host cell invasion YP_001848748.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_001848749.1 function unknown, probably involved in cellular metabolism YP_001848751.1 function unknown, probably involved in a cellular metabolism YP_001848752.1 possibly involved in degradation [catalytic activity: hydrolysis of terminal, non-reducing beta-D- glucose residues with release of beta-D-glucose] YP_001848754.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001848756.1 function unknown, possibly involved in transport of drug across the membrane YP_001848758.1 possibly involved in transcriptional mechanism YP_001848759.1 function unknown; probably involved in cellular metabolism YP_001848760.1 function unknown, hydrolyzes peptides and/or proteins YP_001848764.1 function unknown. thought to be involved in fatty acid transport YP_001848768.1 function unknown. thought to be involved in fatty acid transport YP_001848770.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001848773.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP YP_001848774.1 activates fatty acids by binding to coenzyme A YP_001848775.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001848777.1 function unknown, but involved in lipid degradation YP_001848783.1 function unknown, lipolytic enzyme probably involved in cellular metabolism YP_001848785.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001848786.1 function unknown, but involved in lipid degradation YP_001848788.1 function unknown, but involvement in lipid degradation YP_001848789.1 involved in peptide synthesis and/or lipid metabolism YP_001848790.1 possibly involved in transcriptional mechanism YP_001848791.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001848792.1 thought to oxidize a wide variety of aliphatic and aromatic aldehydes YP_001848793.1 causes methylation YP_001848794.1 function unknown, contains a glycosyltransferase domain (cell envelope biogenesis, outer membrane) YP_001848797.1 function unknown, probably involved in cellular metabolism YP_001848798.1 function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection YP_001848806.1 enzymatic activity is not yet known [catalytic activity: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol] YP_001848807.1 function unknown, but involved in lipid degradation YP_001848808.1 involved in transcriptional mechanism YP_001848809.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate YP_001848813.1 glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate] YP_001848819.1 possibly involved in transcriptional mechanism YP_001848820.1 function unknown, possibly ion channel involved in transport of chloride across the membrane YP_001848822.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001848823.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001848824.1 function unknown, but involved in lipid degradation YP_001848825.1 function unknown, probably involved in cellular metabolism YP_001848829.1 catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source YP_001848830.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001848831.1 could be involved in interconversion of fumarate and succinate (aerobic respiration). this hydrophobic component may be required to anchor the catalytic components of the succinate dehydrogenase complex to the cytoplasmic membrane YP_001848832.1 In M. tuberculosis this gene is down regulated by HspR|Rv0353 YP_001848834.1 thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR YP_001848835.1 involved in nitrate assimilation (denitrification) (at the second step). this enzyme is a fad flavoprotein that also contains a siroheme and one 2Fe-2S iron-sulfur center [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O.] YP_001848836.1 involved in nitrate assimilation (denitrification); required for activity of the reductase [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O.] YP_001848839.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane YP_001848840.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane YP_001848841.1 confers resistance to aminoglycosides (gentamicin, tobramycin, dibekacin, netilmicin, and 6'-N- ethylnetilmicin) YP_001848844.1 thought to be involved in iron transport across the membrane (import) YP_001848845.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane YP_001848847.1 activates fatty acids by binding to coenzyme A YP_001848849.1 function unknown, but involved in lipid degradation YP_001848850.1 involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH] YP_001848852.1 could be involved in transcriptional mechanism YP_001848855.1 could be involved in transcriptional mechanism YP_001848869.1 thought to have proteolytic activity YP_001848872.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate YP_001848873.1 function unknown, probably involved in cellular metabolism YP_001848874.1 function unknown, probably involved in cellular metabolism YP_001848886.1 possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls YP_001848887.1 could be involved in the catabolism of catechol to succinate- and acetyl-CoA in the beta-ketoadipate pathway (at the third step) [catalytic activity: 2,5-dihydro-5- oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate] YP_001848889.1 phosphorylation of carbohydrates YP_001848890.1 carbohydrate metabolism YP_001848892.1 function unknown but may have hydrolytic activity YP_001848895.1 function unknown; probably involved in cellular metabolism YP_001848896.1 function unknown; belongs to the major facilitator superfamily (MFS) YP_001848897.1 3-dehydroquinate (DHQ) synthase catalyses the formation of dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate. this reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids YP_001848900.1 domain homology to NagC, transcriptional regulator/sugar kinase [transcription / carbohydrate transport and metabolism] YP_001848901.1 function unknown; similarity to cyclitol dehydrogenase from actinoplanes sp. 50/110 YP_001848906.1 function unknown; probably involved in cellular metabolism YP_001848908.1 possible phage recombinase YP_001848912.1 involved in transcriptional mechanism YP_001848915.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline YP_001848916.1 may be exported YP_001848917.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001848923.1 dTDP-L-rhamnose biosynthesis within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis [catalytic activity: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose] YP_001848924.1 Ortholog of PE_PGRS9 YP_001848926.1 function unknown, member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins YP_001848927.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001848929.1 involved in transcriptional mechanism YP_001848931.1 function unknown function but ortholog in M.tuberculosis induced by isoniazid and ethionamide YP_001848932.1 in M. tuberculosis H37Rv this gene is induced by isoniazid (INH) or ethionamide treatment) (see wilson et al., 1999) YP_001848933.1 in M. tuberculosis H37Rv IniC is an isoniazid- inducible gene YP_001848938.1 probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001848943.1 involved in L-asparagine transport YP_001848944.1 function unknown; domain homology with alkanesulfonate_monoxygenase YP_001848945.1 function unknown; FabG-like enzyme YP_001848947.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001848948.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001848949.1 one of the components of the high-affinity ATP- driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. the C subunit may be involved in assembly of the Kdp complex. [catalytic activity: ATP + H(2)O + K(+)(out) = ADP + phosphate + K(+)(in)] YP_001848950.1 member of the two-component regulatory system KdpD/KdpE involved in the regulation of the Kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals YP_001848951.1 receiver domain of the two-component regulatory system Kdp/KdpE involved in the regulation of the Kdp operon YP_001848953.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001848954.1 stimulates, jointly with DnaJ, the ATPase activity of DnaK. helps to release ADP from DnaK thus allowing DnaK to recycle more efficiently. seems to be regulated negatively by HspR YP_001848955.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001848956.1 involved in transcriptional regulation (repression) of heat shock proteins E.G. DnaK, GrpE, DnaJ1. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock YP_001848959.1 possible carbohydrate transport and metabolism YP_001848960.1 function unknown, probably involved in cellular metabolism YP_001848961.1 ATPase subunit of an intracellular ATP-dependent protease. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR YP_001848962.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001848964.1 function unknown, but possibly involvement in lipid metabolism YP_001848965.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001848967.1 possibly causes methylation of RNA YP_001848968.1 thought to be involved in protein transport (export) YP_001848969.1 possibly involved in transcriptional mechanism YP_001848971.1 function unknown; probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001848972.1 function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001848973.1 function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001848976.1 function unknown, probably involved in cellular metabolism YP_001848977.1 function unknown, probably involved in cellular metabolism YP_001848979.1 catalyzes the formation of acetaldehyde from ethanolamine YP_001848980.1 ethanolamine catabolism. catalyzes the conversion of ethanolamine to acetaldehyde in the presence of coenzyme B12 or adenosylcobalamin (AdoCbl) YP_001848981.1 thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane YP_001848982.1 involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate] YP_001848985.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001848986.1 thought to be involved in Mg2+ transport. responsible for the translocation of the substrate across the membrane YP_001848992.1 involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids YP_001848993.1 possibly involved in export of metal ions across the membrane YP_001848996.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001849000.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001849001.1 contains conserved rhodanese domain superfamily, subgroup 1. this domain includes the putative rhodanese- related sulfurtransferases of several uncharacterized proteins YP_001849002.1 involved in methionine biosynthesis. converts O- succinylhomoserine into homocysteine YP_001849003.1 transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation YP_001849004.1 function unknown, but seems involved in efflux system (probably sugar or drug transport) YP_001849005.1 function unknown but high domain identity with choline/carnitine o-acyltransferases YP_001849006.1 gamma-butyrobetaine hydroxylase is a 2-oxoglutarate- dependent dioxygenase that catalyzes the hydroxylation of gamma-butyrobetaine to carnitine, the last step in the biosynthesis of carnitine from lysine. reaction catalysed: 4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) <=> 3- hydroxy-4-trimethylammoniobutanoate + succinate + CO(2) YP_001849007.1 decarboxylation of aspartate. this is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase which requires a pyruvoyl group for its activity YP_001849008.1 function unknown, contains two UbiE domains: methylase involved in ubiquinone/menaquinone biosynthesis YP_001849011.1 function unknown, but involved in lipid degradation YP_001849012.1 function unknown, but involved in lipid degradation YP_001849014.1 function unknown but has domain identity with acetyltransferases YP_001849015.1 function unknown; probably involved in cellular metabolism YP_001849017.1 function unknown: involved in energy production and conversion YP_001849018.1 function unknown. thought to be involved in fatty acid transport YP_001849020.1 activates fatty acids by binding to coenzyme A YP_001849021.1 production of unknown apolar lipid. contains two modules. KS-ATa-ACP, KS-ATa-ACP and terminal te domain YP_001849023.1 catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor YP_001849024.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001849025.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001849027.1 involved in signal transduction (via phosphorylation). thought to regulate amino-acid uptake and stationary-phase metabolism. phosphorylates the peptide substrate myelin basic protein (MBP) at serine residues [catalytic activity: ATP + a protein = ADP + a P YP_001849028.1 involved in active transport of glutamine across the membrane (import). interacts with the glutamine- transport system YP_001849030.1 possibly involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8- dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8- OXO-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to a.T to G.C transversions. mutt specifically degrades 8-OXO- dGTP to the monophosphate [catalytic activity: 8-OXO-dGTP + H2O = 8-OXO-DGMP + pyrophosphate] YP_001849031.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_001849032.1 involved in thiamine biosynthesis YP_001849033.1 part of the thiamine biosynthesis operon. ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. It is coded in the THICEFSGH operon in E. coli YP_001849034.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001849035.1 function unknown but domain identity with streptomyces scabies esterase protein YP_001849040.1 function unknown, hydrolyzes peptides and/or proteins YP_001849041.1 function unknown; hydrolyzes peptides and/or proteins YP_001849042.1 function unknown, possibly hydrolyzes peptides and/or proteins YP_001849043.1 function unknown, but may be involved in efflux system (probably sugar or drug transport) YP_001849044.1 function unknown but contains a N-term CheY-like response regulator receiver domain and C-term adenylyl/guanylyl cyclase catalytic domain YP_001849047.1 two TetR DNA-binding domains detected YP_001849049.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001849050.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001849051.1 function unknown but may be involved in signal transduction pathway as it contains a PAS-like central senor domain and an Antar domain YP_001849052.1 function unknown but domain identity shared with the anti-sigma factor antagonist superfamily spoiiaa YP_001849055.1 metal cation-transporting ATPase; may catalyze the transport of undeterminaed metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminted metal cation (in) = ADP + phosphate + undeterminaed metal cation (out)] YP_001849057.1 involved in base excision repair. apurinic- apyrimidinic endonuclease. supposed to remove the damaged DNA at cytosines and guanines by cleaving at the 3' side of the ap site by a beta-elimination reaction. possibly exhibites 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'- repair diesterase and ribonuclease H activities [catalytic activity: degradation of double-stranded DNA. it acts progressively in a 3'- to 5'-direction, releasing 5'- phosphomononucleotides] YP_001849059.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001849062.1 destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 superoxide + 2 H+ = O2 + H2O2] YP_001849063.1 ATP-dependent carboxylate-amine ligase YP_001849064.1 involved in transcriptional mechanism YP_001849065.1 function unknown, possibly involved in inorganic ion transport YP_001849067.1 ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)] YP_001849068.1 involved in phospholipid biosynthesis. generates phosphatidylserine [catalytic activity: CDP-diacylglycerol + L-serine = CMP + O-SN-phosphatidyl-L-serine] YP_001849069.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_001849071.1 involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes (by similarity) YP_001849072.1 function unknown, possibly involved in cellular metabolism YP_001849074.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001849077.1 hydrolizes a specific D-amino acid YP_001849081.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins YP_001849083.1 transfers a methylene group from S-adenosyl-L- methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge [catalytic activity: S-adenosyl-L- methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid] YP_001849086.1 thought to be involved in fatty acid transport YP_001849090.1 the function of MmpL proteins is not known, although it has been suggested that they may be involved in lipid transport YP_001849093.1 catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001849094.1 function unknown; hydrolyzes peptides and/or proteins YP_001849095.1 interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH] YP_001849099.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2] YP_001849100.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component YP_001849105.1 possibly involved in transcriptional mechanism YP_001849107.1 involved in glyoxylate bypass (at the first step), an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi) [catalytic activity: isocitrate = succinate + glyoxylate]. involved in the persistence in the host YP_001849108.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_001849109.1 involved in mycolic acid modification or synthesis YP_001849110.1 transposition of ISMyma04 YP_001849111.1 involved in the mycolic acid modification or synthesis; essential for the cyclopropanation function. required for cording and mycolic acid cyclopropane ring synthesis in the cell wall YP_001849112.1 possibly involved in transcriptional mechanism YP_001849114.1 possibly involved in transcriptional mechanism YP_001849115.1 required for extrapulmonary dissemination. mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells; binds heparin, dextran sulfate, fucoidan and chondroitin sulfate. promotes hemagglutination of erythrocytes of certain host species. induces mycobacterial aggregation YP_001849118.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001849120.1 function unknown, hydrolytic enzyme probably involved in cellular metabolism YP_001849123.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001849125.1 function unknown, possibly involved in cellular metabolism YP_001849126.1 possibly involved in transcriptional mechanism YP_001849127.1 thought to be involved in polyprenolmannose synthesis YP_001849129.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001849130.1 sensor part of a two-component regulatory system. probably forms part of a two-component regulatory system SenX3/RegX3; phosphorylates RegX3 YP_001849131.1 transcriptional regulatory protein part of the two-component regulatory system RegX3/SenX3 YP_001849132.1 function unknown, probably involved in cellular metabolism YP_001849135.1 involved in transcriptional mechanism YP_001849141.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001849144.1 involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose] YP_001849146.1 essential for the cyclopropanation function. transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge. mycolic acids, which represent the major constituent of mycobacterial cell wall complex, act as substrates [catalytic activity: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L- homocysteine + phospholipid cyclopropane fatty acid] YP_001849148.1 removes a phosphate from phosphoserine [catalytic activity: phosphoserine + H2O = serine + phosphate] YP_001849149.1 involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001849150.1 function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001849151.1 involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor] YP_001849154.1 Transposon insertion in this sequence results in intracellular replication deficiency YP_001849156.1 thought to be involved in fatty acid transport YP_001849158.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001849159.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001849160.1 possibly involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L- methionine + uroporphyrin III = 2 S-adenosyl-L- homocysteine + sirohydrochlorin] YP_001849161.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001849164.1 function unknown. contains 8 predicted modules, each with a minimum domain complement (C, a & T domains), responsible for the synthesis of an 8 amino acid metabolite. predicted sequential condensation of the following amino acids: F, R or F, F, T, F, F or C, L, F and followed by an integral thioesterase domain YP_001849165.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. some have been shown to bind tightly to a range of azole-based antifungal drugs (E.G. miconazole, clotrimazole) YP_001849168.1 function unknown, domain identity to secreted hydrolases of the SgnH_hydrolase subfamily YP_001849171.1 has homology to a putative esterase domain YP_001849172.1 the universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general 'stress endurance' activity YP_001849173.1 metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation(out) YP_001849174.1 contains a UbiE domain: methylase involved in ubiquinone/menaquinone biosynthesis YP_001849175.1 involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane YP_001849176.1 ketopantoate reductase PanE/ApbA. this is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases. the reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and pane are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway YP_001849179.1 contains glutaredoxin domain YP_001849182.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001849183.1 contains fructose-2,6-bisphosphatase domain [carbohydrate transport and metabolism] YP_001849185.1 required during cytochrome biogenesis at the step of HemE attachment YP_001849186.1 required for cytochrome C biosynthesis YP_001849187.1 required during cytochrome biogenesis at the step of HemE attachment YP_001849191.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001849192.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001849193.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate YP_001849194.1 involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose] YP_001849197.1 substrate (sugar) unknown [catalytic activity: NDP- sugar + dolichyl phosphate = NDP + dolichyl sugar phosphate] YP_001849200.1 involved in menaquinone biosynthesis. O- succinylbenzoic acid (OSB) to O-succinylbenzoyl-CoA (OSB- CoA) [catalytic activity: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA] YP_001849203.1 involved in low-affinity inorganic phosphate transport across the membrane. responsible for the translocation of the substrate across the membrane YP_001849207.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001849209.1 activates fatty acids by binding to coenzyme A YP_001849210.1 has significant domain identity to predicted metal- dependent hydrolases YP_001849211.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_001849212.1 non-haem peroxidase YP_001849213.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001849215.1 involved in lipoarabinomannan (lam) biosynthesis YP_001849216.1 mar family YP_001849219.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001849222.1 has significant domain conservation with dehydrogenases (flavoproteins) [energy production and conversion] YP_001849223.1 supplies polyprenyl diphosphate YP_001849224.1 putative metalloprotease YP_001849225.1 generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane YP_001849227.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001849228.1 hydrolyzes peptides and/or proteins. cleaves preferentially after serine residues YP_001849229.1 function unknown but domain identity suggests this CDS encodes a flavoprotein involved in K+ transport YP_001849230.1 function unknown; the lantibiotics are a group of ribosomally synthesised, post-translationally modified peptides containing unusual amino acids, such as dehydrated and lanthionine residuesthe lantibiotics are a group of ribosomally synthesised, post-translationally modified peptides containing unusual amino acids, such as dehydrated and lanthionine residues YP_001849231.1 domain identity to N-acetylases of ribosomal proteins YP_001849232.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001849233.1 ABC-type transport system, involved in lipoprotein release, permease component YP_001849235.1 involved in transcriptional mechanism YP_001849237.1 NhaP-type Na+/H+ and K+/H+ antiporter: inorganic ion transport and metabolism]. antiporters are ubiquitous membrane proteins that are involved in homeostasis of H(+) and na(+) throughout the biological kingdom YP_001849240.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001849241.1 involved in transcriptional mechanism YP_001849242.1 involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB YP_001849249.1 component of the translational apparatus. furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. the reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-glu-tRNA(Gln) [catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L- glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L- glutamate] YP_001849250.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001849252.1 involved in galactose metabolism (Leloir pathway) [catalytic activity: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose] YP_001849253.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001849254.1 ArsR family YP_001849259.1 contains hydrolase domain YP_001849264.1 function unknown role incarbohydrate transport and metabolism YP_001849266.1 function unknown, imidazolonepropionase is an amidohydrolase YP_001849268.1 involved in homologous recombination YP_001849269.1 involved in homologous recombination YP_001849270.1 involved in homologous recombination YP_001849272.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide YP_001849273.1 function unknown; predicted esterase domains YP_001849274.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001849276.1 thought to be involved in glyoxal pathway. thioesterase that catalyses the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy acid anion] YP_001849277.1 domain homology to Arc/MetJ class transcription regulators YP_001849278.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif YP_001849279.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II YP_001849280.1 functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II YP_001849281.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II YP_001849282.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001849283.1 Modulates Rho-dependent transcription termination YP_001849284.1 binds directly to 23S ribosomal RNA YP_001849285.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001849287.1 May play a role in initiation of transcription YP_001849288.1 methyltransferase. involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine- dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase YP_001849289.1 methyltransferase involved in mycolic acid biosynthesis YP_001849290.1 involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase YP_001849291.1 involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase YP_001849293.1 contains a kinase domain and ATP-binding cassette YP_001849296.1 alpha-mannosidase activity: hydrolysis of terminal non-reducing alpha-D-mannose residues in alpha-D- mannosides YP_001849297.1 involved in lipid metabolism; fatty acid biosynthesis [catalytic activity: malonyl-CoA + [acyl- carrier protein] = CoA + malonyl-[acyl-carrier protein]] YP_001849298.1 potential pseudogene due to C-term disruption by ISMyma04; function unknown; probably involved in specific sugar metabolism or regulation YP_001849299.1 transposition of ISMyma04 YP_001849301.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001849302.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001849303.1 function unknown, involved in transcriptional mechanism YP_001849304.1 dioxygenase and related enzymes [secondary metabolites biosynthesis, transport, and catabolism] YP_001849305.1 thought to be involved in active transport of ribonucleotide across the membrane. responsible for energy coupling to the transport system YP_001849306.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001849307.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001849311.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_001849313.1 may be involved in lipid degradation YP_001849314.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001849315.1 high domain identity with transcriptional repressors YP_001849316.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001849317.1 thought to be involved in fatty acid transport YP_001849322.1 involved in transcriptional mechanism YP_001849323.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001849324.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001849325.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001849326.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001849328.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001849329.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001849331.1 involved in transcriptional mechanism YP_001849333.1 required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis YP_001849334.1 involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C] YP_001849335.1 catalyses the hydrolysis of creatinine to creatine YP_001849338.1 involved in transcriptional mechanism YP_001849339.1 N-term truncated compared to orthologues YP_001849343.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001849344.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001849345.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001849346.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001849347.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001849348.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001849349.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001849350.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001849351.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001849352.1 one of the stabilizing components for the large ribosomal subunit YP_001849353.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001849358.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001849359.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001849360.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001849361.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_001849362.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001849363.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001849364.1 binds 5S rRNA along with protein L5 and L25 YP_001849365.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001849366.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001849367.1 late assembly protein YP_001849369.1 involved in digestion of the cleaved signal peptides. this activity is necessary to maintain proper secretion of mature proteins across the membrane YP_001849374.1 involved in transcriptional mechanism YP_001849375.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_001849376.1 involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis. catalyzes the oxidation of D-3-phosphoglycerate to 3- phosphohydroxypyruvate [catalytic activity: 3- phosphoglycerate + NAD(+) = 3-phosphohydroxypyruvate + NADH] YP_001849377.1 phosphorylates D-xylulose [catalytic activity: ATP + D-xylulose = ADP + D-xylulose 5-phosphate] YP_001849381.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001849382.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001849383.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001849384.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins YP_001849385.1 function unknown, domain identity suggests possible role in transcription regulation YP_001849386.1 involved in transcriptional mechanism YP_001849388.1 catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3- oxopropanoate + NADH] YP_001849389.1 lipid metabolism YP_001849390.1 plays a role in valine and pyrimidine metabolism. binds fatty acyl-CoA [catalytic activity: 2-methyl-3- oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH] YP_001849392.1 involved in dTDP-L-rhamnose biosynthesis, within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis: conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-rhamnose [catalytic activity: DTDP-4- dehydro-6-deoxy-D-glucose = DTDP-4-dehydro-6-deoxy-L- mannose] YP_001849393.1 involved in dTDP-L-rhamnose biosynthesis [catalytic activity: dTDP-glucose = DTDP-4-dehydro-6-deoxy-D-glucose + H(2)O] YP_001849396.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001849397.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001849398.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001849399.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001849400.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001849401.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001849402.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001849403.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001849404.1 permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_001849407.1 similar to other proteins involved in nucleotide transport YP_001849408.1 hydrolysis of cutin (a polyester that forms the structure of plant cuticle) YP_001849413.1 function unknown but has 3 ATP binding P-loop motifs YP_001849417.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001849418.1 forms a direct contact with the tRNA during translation YP_001849419.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001849422.1 function unknown but domain identity with flavin- dependent oxidoreductases YP_001849423.1 hydrolase domain identity YP_001849425.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001849428.1 has domain identity with YjeF-related protein N- terminus and sugar kinases c-terminus YP_001849429.1 catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)] YP_001849430.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001849432.1 ATPase domain YP_001849433.1 peptidase YP_001849434.1 this enzyme acetylates the N-terminal alanine of ribosomal protein S18 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine] YP_001849435.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001849436.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001849437.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth YP_001849438.1 possible transcriptional regulator YP_001849441.1 N-term truncation of 14 aa compared to M. ulcerans (frame shift mutation) YP_001849444.1 intracellular redox sensor that integrates environmental redox signals with core intermediary metabolism YP_001849446.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase YP_001849449.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001849450.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001849452.1 involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)] YP_001849453.1 in E. coli this enzyme catalyses the oxygenolytic release of sulfite from taurine YP_001849454.1 involved in transcriptional mechanism YP_001849455.1 similar to maltose phosphorylase, a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose YP_001849456.1 cellular metabolism YP_001849458.1 involved in transcriptional mechanism YP_001849460.1 involved in transcriptional mechanism YP_001849461.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001849464.1 function unknown but belongs to the DNA/RNA polymerase superfamily YP_001849465.1 involved in purine salvage. catalyzes the hydrolysis of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base, and could have a preference for inosine and uridine as substrates [catalytic activity: a N-D-ribosylpurine + H(2)O = a purine + d- ribose] YP_001849466.1 multifunctional protein with fatty acyl-CoA reductase activity in C-terminal part YP_001849468.1 may have dehydratase activity; contains a MaoC protein family domain YP_001849469.1 involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate] YP_001849471.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase. YP_001849473.1 function unknown, probably involved in cellular metabolism YP_001849476.1 involved in rRNA methylation YP_001849477.1 function unknown but may be involved in RNA methylation YP_001849478.1 function unknown but may be a regulatory protein as it contains a signal transduction histidine kinase domain YP_001849483.1 function unknown, but involved in lipid degradation YP_001849484.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2] YP_001849485.1 function unknown, probably involved in cellular metabolism YP_001849486.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001849487.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001849488.1 function unknown; probably involved in cellular metabolism YP_001849489.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001849492.1 function unknown, probably involved in cellular metabolism YP_001849493.1 N-term fused in-frame with fatty acyl-AMP ligase FadD28_1; Synthesis of unknown polyketide YP_001849496.1 causes methylation YP_001849497.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_001849498.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_001849499.1 Converts isocitrate to alpha ketoglutarate YP_001849501.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001849503.1 involved in N-acetyl glucosamine utilization pathway [catalytic activity: N-acetyl-D-glucosamine 6- phosphate + H(2)O = D-glucosamine 6-phosphate + acetate] YP_001849504.1 thought to be involved in transport of sugar across the membrane. responsible for the translocation of the substrate across the membrane YP_001849505.1 involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine] YP_001849507.1 possible inter-alpha-trypsin inhibitor family heavy chain-related protein-hypothetical secreted or membrane- associated protein containing vWFA domain YP_001849509.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001849513.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001849514.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001849515.1 involved in tricarboxylic acid cycle. putative hydrophobic component of the succinate dehydrogenase complex. could be required to anchor the catalytic components to the cytoplasmic membrane YP_001849516.1 involved in tricarboxylic acid cycle. mono-heme cytochrome of the succinate dehydrogenase complex YP_001849517.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_001849518.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_001849519.1 catalyzes the formation of inosine from adenosine YP_001849523.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate YP_001849524.1 function unknown, contains xylanase/chitin deacetylase domain YP_001849525.1 function unknown but contains permease domain and may be involved in nucleotide transport (cytosine/purines) and metabolism/coenzyme metabolism YP_001849526.1 function unknown. thought to be regulated by LexA YP_001849527.1 function unknown but contains hydrolase domain YP_001849529.1 involved in cellular metabolism: acting on ester bonds [catalytic activity: an orthophosphoric monoester + H(2)O = an alcohol + orthophosphate] YP_001849530.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001849531.1 converts D-mannose 1-phosphate to D-mannose 6- phosphate YP_001849532.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001849533.1 involved in cellular metabolism, active on carbon aliphatic amides and/or on many aromatic amides [catalytic activity : a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)] YP_001849534.1 function unknown, hydrolysis of L-amino acids YP_001849537.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity YP_001849538.1 involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor] YP_001849539.1 function unknown but may be involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH] YP_001849541.1 metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)] YP_001849542.1 involved in transcriptional regulation of active transport of inorganic phosphate across the membrane YP_001849543.1 thought to be involved in transport of magnesium and cobalt ions across the membrane. responsible for the translocation of the substrate across the membrane YP_001849544.1 catalyses the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi) YP_001849545.1 generates sulfate and phenol from phenol sulfate [catalytic activity: a phenol sulfate + H(2)O = a phenol + sulfate] YP_001849547.1 involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport YP_001849548.1 function unknown. possibly a protective antigen involved with the early control of infection YP_001849549.1 function unknown, lipolytic enzyme involved in cellular metabolism YP_001849550.1 involved in damage reversal. DNA N-glycosylase with an ap lyase activity. required for the repair of oxidative DNA damage (oxidized pyrimidines) YP_001849551.1 function unknown but has both ATPase and helicase activities YP_001849552.1 involved in transcriptional mechanism YP_001849553.1 involved in L-alpha-aminoadipic acid (L-AAA) biosynthesis (in the second step; the first step is promoted by Lat enzyme YP_001849555.1 involved in transcriptional mechanism YP_001849556.1 catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate YP_001849560.1 binds to sigma and blocks its ability to form an RNA polymerase holoenzyme. regulates negatively SigF and negatively regulated by RsfA and RsfB YP_001849561.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock YP_001849562.1 involved in transcriptional mechanism YP_001849563.1 function unknown but contains 3 modules for the potential synthesis of a tripeptide YP_001849564.1 involved in long-chain fatty acid synthesis (at the first step). carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein] YP_001849565.1 probably involved in Fe-S center assembly YP_001849566.1 possibly a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate] YP_001849567.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001849569.1 key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.] YP_001849570.1 BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl- CoA:carbon-dioxide ligase. this protein also activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [catalytic activity: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP forming)] = AMP + pyrophosphate + [acetyl- CoA:carbon-dioxide ligase (ADP forming)]] YP_001849573.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001849574.1 involved in purine biosynthesis (sixth step). this subunit can alone transform air to cair, but in association with PurK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting air to cair efficiently under physiol YP_001849575.1 function unknown, but involved in lipid metabolism [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF] YP_001849578.1 sensor part of the two-component regulatory system YP_001849579.1 generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane YP_001849584.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)] YP_001849585.1 function unknown YP_001849588.1 involved in dTDP-L-rhamnose biosynthesis: converts dTDP-6-deoxy-L-lyxo-4-hexulose to dTDP-L-rhamnose with the concomitant oxidation of NADPH to NADP+ [catalytic activity: dTDP-6-deoxy-L-lyxo-4-hexulose + NADPH = dTDP-L- rhamnose + NADP+] YP_001849589.1 involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall. seems to be essential for mycobacterial viability YP_001849590.1 involved in GDP-mannose biosynthesis and biosynthesis of nucleotide-activated glycero-manno-heptose (D-alpha-D pathway): generates GDP-mannose and phosphate from GTP and alpha-D-mannose 1-phosphate. ManB product is needed for all mannosyl glycolipids and polysaccharides which, like rhamnosyl residues, are an important part of the mycobacterium envelope [catalytic activity: alpha-D- mannose 1-phosphate + GTP = GDP-mannose + phosphate] YP_001849592.1 causes DNA methylation YP_001849593.1 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0) YP_001849594.1 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) YP_001849595.1 involved in transcriptional mechanism YP_001849598.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells YP_001849600.1 this enzyme converts D-mannose 6-phosphate to D- fructose 6-phosphate [catalytic activity: D-mannose 6- phosphate = D-fructose 6-phosphate] YP_001849601.1 function unknown but contains dehydrogenase domain YP_001849603.1 thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane YP_001849604.1 thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O] YP_001849605.1 involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase YP_001849606.1 involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase YP_001849607.1 probably involved in a transcriptional mechanism YP_001849608.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_001849611.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001849612.1 transcriptional activator part of a two-component regulatory system YP_001849613.1 sensor part of a two-component regulatory system YP_001849616.1 function unknown, but contains amidophosphoribosyltransferase domain YP_001849617.1 function unknown but has domain identity with sigma 54 modulation protein YP_001849618.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001849619.1 function unknown, but seems involved in efflux system (probably sugar or drug transport) YP_001849621.1 function unknown but has a putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [inorganic ion transport and metabolism] YP_001849622.1 probably involved in transport of undeterminated substrate (possibly cations Na/H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane YP_001849625.1 possibly involved in transcriptional mechanism (probably sigma factor promoting attachment of the RNA polymerase to specific initiation sites) YP_001849627.1 function unknown, probably involved in cellular metabolism YP_001849628.1 thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O] YP_001849629.1 thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O] YP_001849630.1 function unknown, but involved in lipid metabolism [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA] YP_001849631.1 function unknown. could be involved in regulatory mechanism YP_001849633.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001849635.1 thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle [catalytic activity: (S)-3- hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH] YP_001849638.1 may be involved in regulation YP_001849647.1 function unknown, probably involved in cellular metabolism YP_001849648.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001849649.1 binds sigma factor and inhibits it. probably involved in survival following heat shock and oxidative stress YP_001849651.1 sensor part of a two-component regulatory system YP_001849652.1 involved in transcriptional mechanism YP_001849655.1 function unknown, involved in cellular metabolism YP_001849656.1 could be involved in enterobactin biosynthesis. enterobactin is an iron-chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm. could be also involved in 2,3- dihydroxybenzoate or enterochelin or menaquinone biosynthesis [catalytic activity: chorismate = isochorismate] YP_001849657.1 forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily YP_001849658.1 possibly involved in control of chromosome partitioning YP_001849660.1 has a helix-destabilizing activity YP_001849664.1 involved in transcriptional mechanism YP_001849666.1 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation YP_001849668.1 causes methylation of DNA YP_001849669.1 function unknown, presumed lipolytic enzyme involved in cellular metabolism YP_001849672.1 has both ATPase and helicase activities YP_001849673.1 has both ATPase and helicase activities YP_001849674.1 thought to be involved in cation transport across the membrane YP_001849675.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_001849678.1 involved in nucleotide excision repair. has both ATPase and helicase activities. unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single- stranded region is present. involved in the postincision events of nucleotide excision repair and methyl-directed mismatch repair YP_001849679.1 involved in transcriptional mechanism YP_001849680.1 thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system YP_001849687.1 transposition of ISMyma05 YP_001849688.1 function unknown, possible role in posttranslational modification, protein turnover, chaperonefunctions YP_001849689.1 thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate] YP_001849692.1 involved in transcriptional mechanism YP_001849695.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_001849701.1 possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)] YP_001849702.1 supposed involved in detoxification reactions YP_001849703.1 may catalyze the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]. may have important function in metabolism. supposed involved YP_001849704.1 function unknown, probably involved in cellular metabolism YP_001849708.1 involved in transcriptional mechanism YP_001849709.1 function unknown, possibly involved in cellular metabolism YP_001849710.1 transposition of ISMyma02 YP_001849713.1 involved in transcriptional mechanism; regulates methanol dehydrogenase YP_001849717.1 transposition of ISMyma02 YP_001849721.1 transposition of ISMyma02 YP_001849722.1 transposition of ISMyma03 YP_001849723.1 transposition of ISMyma03 YP_001849729.1 possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate] YP_001849730.1 function unknown. contains a SAM-dependent methyltransferase domain YP_001849733.1 function unknown; domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide YP_001849734.1 Single copy element YP_001849736.1 involved in signal transduction (via phosphorylation). catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001849738.1 single copy element YP_001849742.1 function unknown, contains a N-term cation transport ATPase domain YP_001849744.1 metal cation-transporting ATPase; possibly catalyzes the transport of zinc with hydrolysis of ATP [catalytic activity: ATP + H(2)O + zinc (in) = ADP + phosphate + zinc (out)] YP_001849746.1 domain identity with XerD and XerC integrases, DNA breaking-rejoining enzymes, n- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance YP_001849749.1 Single copy element. there are 24 copies of this element in M. smegmatis MC2155 YP_001849752.1 high domain identity with a protein kinase YP_001849753.1 involved in transcriptional mechanism YP_001849754.1 transposition of insertion sequence ISMyma02 YP_001849756.1 metal cation-transporting ATPase; possibly catalyzes the transport of zinc metal cations with hydrolysis of ATP [catalytic activity: ATP + H(2)O + zinc metal cations (in) = ADP + phosphate + zinc metal cations (out)] YP_001849757.1 function unknown YP_001849759.1 transposition of ISMyma02 YP_001849760.1 transposition of the insertion sequence ISMyma01 YP_001849761.1 transposition of the insertion sequence ISMyma01 YP_001849763.1 transposition of ISMyma03 YP_001849764.1 transposition of ISMyma03 YP_001849773.1 Single copy element; transposition of an insertion sequence YP_001849774.1 transposition of the insertion sequence ISMyma02 YP_001849776.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849777.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849778.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001849779.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849780.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849781.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849782.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849783.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849784.1 involved in aerobic|anaerobic respiration [catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol] YP_001849785.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849786.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849787.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849788.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001849789.1 Catalyzes the transfer of electrons from NADH to quinone YP_001849791.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate] YP_001849797.1 involved in lipid degradation YP_001849798.1 involved in transcriptional mechanism YP_001849804.1 involved in lipid degradation [catalytic activity: NADPH + quinone = NADP(+) + semiquinone] YP_001849805.1 function unknown, probably involved in cellular metabolism YP_001849807.1 function unknown, C-term identity with glyoxalase domains YP_001849808.1 function unknown, N-term has esterase domain identity YP_001849809.1 function unknown role in energy production/conversion YP_001849810.1 involved in transcriptional mechanism YP_001849811.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_001849812.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_001849813.1 function unknown, possible role secondary metabolite biosynthesis YP_001849814.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_001849815.1 function unknown, but involved in lipid degradation YP_001849816.1 function unknown, but involved in lipid degradation YP_001849817.1 function unknown, involved in cellular metabolism YP_001849821.1 may play a role in the adaptation to hypoxia, participating in the phosphorelay in the two-component regulatory system DevR/DevS YP_001849822.1 regulator part of the two-component regulatory system DevR/DevS. controls HspX|Acr expression YP_001849823.1 sensor part of the two-component regulatory system DevR/DevS. thought to control HspX|Acr expression YP_001849831.1 involved in ether lipid biosynthesis [catalytic activity: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion] YP_001849832.1 generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH] YP_001849833.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_001849834.1 function unknown but contains mechanosensitive (ms) ion channel forming domain with a possible role in cell envelope biogenesis YP_001849835.1 function unknown: predicted solute binding protein YP_001849836.1 involved in growth. thought to be involved in active transport of septation component across the membrane. responsible for energy coupling to the transport system. coded for in an operon essential for cell division YP_001849837.1 involved in growth (principally during log phase cells). thought to be involved in active transport of septation component across the membrane. responsible for the translocation of the substrate across the membrane. coded for in an operon essential for ce YP_001849838.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001849841.1 ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolysis of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)] YP_001849855.1 catalyzes the formation of glutamate from glutamine YP_001849856.1 function unknown but has domain similarity to predicted flavin-nucleotide-binding proteins YP_001849858.1 contains a phytanoyl-CoA dioxygenase domain YP_001849867.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001849868.1 catalyzes the first step in the biosynthesis of 2- methylthio-n6-(delta(2)-isopentenyl)-adenosine adjacent to the anticodon of several tRNA species [catalytic activity: isopentenyl diphosphate + tRNA = pyrophosphate + tRNA containing 6-isopentenyladenosine] YP_001849869.1 function unknown contains C-term of lysine decarboxylase domain YP_001849870.1 function unknown, contains domain identity with ring hydroxylating dioxygenase beta subunit. this subunit has a similar structure to NTF-2, ketosteroid isomerase and scytalone dehydratase.the degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the substrate by nonheme iron- containing dioxygenases YP_001849871.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001849872.1 function unknown, possible role in methylation of unknown substrate YP_001849873.1 MiaB protein is involved in tRNA biogenesis. it is a bifunctional iron-sulphur enzyme, involved in both thiolation and methylation of isopentenyl-adenosine YP_001849875.1 function unknown; possibly involved in cellular metabolism YP_001849878.1 function unknown but shares esterase domain identity YP_001849879.1 function unknown, first 70 aa missing WRT to orthologues YP_001849884.1 function unknown but domain homology to arylsulfatase a ( AslA )and related enzymes YP_001849887.1 function unknown; probably involved in cellular metabolism YP_001849889.1 function unknown but domain identity suggests transcriptional regulator YP_001849890.1 interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate] YP_001849891.1 function unknown YP_001849896.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_001849897.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_001849898.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_001849901.1 secondary metabolites biosynthesis, transport, and catabolism YP_001849902.1 function unknown, contains a SAM-dependent methyltransferase domain YP_001849903.1 involved in transcriptional mechanism YP_001849904.1 single copy element; transposition of an ISMyma01-like insertion sequence YP_001849905.1 single copy element; transposition of an ISMyma01-like element YP_001849908.1 function unknown, probably involved in cellular metabolism YP_001849910.1 function unknown but contains Cdd pfam03982, DAGAT, diacylglycerol acyltransferase domain YP_001849912.1 function unknown, but involved in lipid degradation YP_001849913.1 involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H] YP_001849914.1 function unknown, probably involved in cellular metabolism YP_001849917.1 involved in transcriptional mechanism YP_001849918.1 involved in transport of multidrugs (tetraphenylphosphonium, erythromycin, ethidium bromide, acriflavine, safranin O, pyronin Y, etc) across the membrane (export): multidrugs resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane YP_001849921.1 acts as a chaperone. involved in induction by stress conditions E.G. heat shock. possibly has an ATPase activity. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR YP_001849922.1 peptide utilization during carbon starvation YP_001849923.1 Catalyses the oxidation of cuprous copper, ferrous iron and diphenolic compounds. Protects against oxidative stress YP_001849926.1 involved in transcriptional mechanism YP_001849928.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_001849929.1 function unknown, supposed involved in cellular metabolism YP_001849930.1 function unknown, but involved in lipid metabolism YP_001849933.1 function unknown but potential nucleic-acid-binding domain YP_001849934.1 function unknown, supposed involvement in lipid metabolism YP_001849935.1 involved in transcriptional mechanism YP_001849939.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001849940.1 involved in transcriptional mechanism YP_001849941.1 function unknown, but similar to various oxidoreductases and enzymes involved in polyketides synthesis YP_001849942.1 involved in transcriptional mechanism YP_001849943.1 function unknown but domain identity suggests NADPH- dependent FMN reductase YP_001849945.1 involved in electron transfer system for ribonucleotide reductase system NRDEF YP_001849946.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_001849947.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001849948.1 involved in transcriptional mechanism YP_001849949.1 function unknown, involved in cellular metabolism YP_001849950.1 involved in transcriptional mechanism YP_001849952.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001849954.1 alcohol dehydrogenase catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: ethanol + NAD = acetaldehyde + NADH. belongs to the zinc-containing 'long-chain' alcohol dehydrogenases YP_001849955.1 may be involved in active transport of FeIII- decitrate across the membrane (import) YP_001849956.1 cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C] YP_001849957.1 generates serine from phosphoserine [catalytic activity: phosphoserine + H(2)O = serine + phosphate] YP_001849958.1 involved in transcriptional mechanism YP_001849959.1 function unknown, probably involved in cellular metabolism YP_001849960.1 function unknown, probably involved in cellular metabolism YP_001849961.1 involved in hydrogen metabolism; FHL pathway YP_001849962.1 involved in hydrogen metabolism YP_001849963.1 possibly involved in hydrogen metabolism YP_001849964.1 involved in hydrogen metabolism; FHL pathway YP_001849965.1 thought to be involved in active transport of undeterminated substrate (possibly iron) across the membrane. responsible for energy coupling to the transport system YP_001849967.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001849973.1 function unknown, possibly involved in cellular metabolism YP_001849974.1 function unknown; probably involved in lipid metabolism YP_001849976.1 function unknown, possible role in DNA replication, recombination, and repair YP_001849977.1 function unknown. possibly involved in signal transduction mechanisms YP_001849978.1 function unknown. thought to be involved in drug export YP_001849979.1 thought to be involved in cell wall biosynthesis and may also act as a sensor of external penicillins YP_001849980.1 transcriptional regulation YP_001849985.1 function unknown, probably involved in cellular metabolism YP_001849986.1 function unknown, possibly involved in cellular metabolism YP_001849989.1 the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) YP_001849990.1 the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) YP_001849994.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine YP_001849995.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001849998.1 causes methylation YP_001849999.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001850000.1 possibly involved in a transcriptional mechanism YP_001850002.1 transposition of the insertion sequence ISMyma01 YP_001850003.1 transposition of the insertion sequence ISMyma01 YP_001850005.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001850006.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001850007.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001850008.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001850009.1 function unknown; probably involved in cellular metabolism YP_001850012.1 function unknown function (putative membrane protein) YP_001850014.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_001850015.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001850016.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001850018.1 function unknown; probably involved in cellular metabolism YP_001850019.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001850020.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001850021.1 function unknown; contains major facilitator superfamily (MFS). the MFS transporters are single- polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients YP_001850022.1 isomerizes HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) to ohed (2-OXO-hept-3-ene-1,7-dioate) YP_001850023.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001850026.1 function unknown. thought to be involved in fatty acid transport YP_001850028.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2] YP_001850029.1 involved in transcriptional mechanism YP_001850030.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001850031.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001850032.1 this protein belongs to the histone like family of prokaryotic DNA-binding proteins which are capable of wrapping DNA to stabilize it, and prevent its denaturation under extreme environmental conditions YP_001850033.1 function unknown, hydrolytic enzyme. possibly involved in removal of damaged nucleotide YP_001850034.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001850036.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001850037.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001850039.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_001850041.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001850042.1 thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle YP_001850043.1 function unknown; probably involved in cellular metabolism YP_001850044.1 required for 70S ribosome assembly YP_001850046.1 catalyzes branch migration in Holliday junction intermediates YP_001850048.1 function unknown, probably involved in cellular metabolism YP_001850050.1 function unknown, lipolytic enzyme involved in cellular metabolism YP_001850053.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_001850054.1 thought to cause methylation YP_001850055.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001850057.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001850059.1 involved in PGL biosynthesis. in M. tuberculosis H37Rv, the product of the mu orthologue (Rv2962c) catalyzes the transfer of a rhamnosyl residue onto p- hydroxybenzoic acid ethyl ester or phenolphthiocerol dimycocerosates YP_001850062.1 function unknown; probably involved in cellular metabolism YP_001850063.1 activates fatty acids by binding to coenzyme A YP_001850064.1 responsible for the direct conversion of chorismate to p-hydroxybenzoate, the substrate used in the production of glycosylated p-hydroxybenzoic acid methyl esters and structurally related phenolphthiocerol glycolipids. in M. tuberculosis, this is the sole enzymatic source of p- hydroxybenzoic acid YP_001850065.1 activates fatty acids by binding to coenzyme A YP_001850066.1 polyketide synthase required for the elongation of p-HBAD derivatives to form p-hydroxybenzoate derivatives which are in turn converted to phenolphthiocerols by the ppsA-E locus. this is a key step in the production of phenolic glycolipids YP_001850068.1 involved in translocation of phthiocerol dimycocerosate (dim) in the cell wall YP_001850069.1 activates fatty acids by binding to coenzyme A YP_001850070.1 function unknown but orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form dim YP_001850071.1 catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids YP_001850072.1 required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis YP_001850073.1 probably involved in active transport of phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall YP_001850074.1 probably involved in active transport of phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall YP_001850075.1 probably involved in active transport of antibiotic and phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. responsible for energy coupling to the transport system YP_001850076.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (partial reduction, decarboxylation) YP_001850077.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with methylmalony CoA (partial reduction) YP_001850078.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (complete reduction) YP_001850079.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (partial reduction) YP_001850080.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension of C18 with Malony CoA (partial reduction) YP_001850081.1 activates fatty acids by binding to coenzyme A YP_001850082.1 function unknown however in M. tuberculosis H37Rv TesA interacts with the PpsE protein. PpsE is part of the phenolphthiocerol synthase PKS cluster YP_001850084.1 function unknown, possibly involved in cell division and chromosome partitioning YP_001850086.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001850087.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001850088.1 function unknown. contains N-term OsmC-like protein domain and C-term AcyP, acylphosphatases domain YP_001850089.1 plays an important role in chromosome structure and partitioning. essential for chromosome partition YP_001850090.1 probably involved in the reception and insertion of a subset of proteins at the membrane: possibly membrane receptor for Ffh YP_001850091.1 thought to be involved in transport of ammonium across the membrane (export). responsible for the translocation of the substrate across the membrane YP_001850092.1 in nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP by GlnD. P-II-UMP allows the deadenylylation of glutamine synthetase (gs), thus activating the enzyme. converserly, in nitrogen excess P-II is deuridylated and promotes the adenylation of gs. P-II indirectly controls the transcription of the gs gene. P-II prevents NR-II catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. when P-II is uridylylated to P-II-UMP, these events are reversed YP_001850093.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK YP_001850096.1 necessary for efficient export of extra-cytoplasmic proteins. binds to the signal sequence when it emerges from the ribosomes YP_001850098.1 involved in signal transduction (via phosphorylation). thought to be involved in cell division/differentiation [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001850099.1 hydrolizes a specific D-amino acid YP_001850100.1 thought to be involved in transcriptional mechanism YP_001850101.1 involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine] YP_001850103.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001850105.1 Essential for efficient processing of 16S rRNA YP_001850106.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001850108.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001850109.1 cleavage of N-terminal leader sequences from secreted protein precursors YP_001850110.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001850114.1 contains WcaG, nucleoside-diphosphate-sugar epimerase domain.; function unknown, possibly involved in galactose metabolism YP_001850115.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001850119.1 thought to be involved in intracellular removal of iron from iron-mycobactin complex. mycobactin is an iron- chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm YP_001850120.1 involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C] YP_001850121.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001850123.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001850124.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001850125.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_001850126.1 involved in transcriptional mechanism YP_001850129.1 involved in transcriptional mechanism YP_001850130.1 Catalyzes the phosphorylation of UMP to UDP YP_001850131.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001850132.1 involved in the phospholipid biosynthesis [catalytic activity: CTP + phosphatidate = pyrophosphate + CDP-diacylglycerol] YP_001850134.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001850135.1 despite a weak homology to thioredoxin this cannot serve as a substrate for thioredoxin reductase; furthermore it has no disulfide reducing activity YP_001850136.1 function unknown, possibly involved in transport of mercury across the membrane YP_001850139.1 may be involved in cytochrome-c biogenesis YP_001850140.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001850142.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001850144.1 function unknown, possibly involved in cell wall biosynthesis YP_001850146.1 removes the amino-terminal methionine from nascent proteins [catalytic activity: L-methionylpeptide + H(2)O = L-methionine + peptide] YP_001850148.1 function unknown, probably involved in cellular metabolism YP_001850156.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2] YP_001850158.1 involved in chorismate biosynthesis YP_001850161.1 HypD is involved in hydrogenase formation. it contains many possible metal binding residues, which may bind to nickel YP_001850162.1 chaperone function in the formation of hydrogenase YP_001850163.1 chaperone function in the formation of hydrogenase YP_001850166.1 HypF participates in the maturation of HupSL and the HupUV proteins YP_001850167.1 function unknown chaperone role, possibly in hydrogenase formation YP_001850168.1 metal-dependant hydrogenase maturating endopeptidase YP_001850172.1 function unknown, but contains a thioredoxin-like domain YP_001850173.1 structural subunit of [nife] hydrogenase YP_001850174.1 small structural subunit for [Ni/Fe] hydrogenase YP_001850175.1 involved in regulation of expression and maturation of urease and hydrogenase YP_001850176.1 involved in hydrogenase synthesis YP_001850177.1 involved in nickel transport - part of the hydrogenase operon YP_001850178.1 role in the regulation of uptake of iron, zinc and other metals YP_001850179.1 catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide YP_001850180.1 lipid metabolism YP_001850181.1 thought to be involved in fatty acid transport YP_001850183.1 thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane YP_001850185.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001850186.1 function unknown, predicted acyltransferase activity YP_001850187.1 function unknown, possibly introduces a magnesium ion into specific substrate/compound YP_001850188.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001850189.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_001850190.1 involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + sirohydrochlorin]. SAM-dependent methyl transferase that methylates uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. it catalyzes also the conversion of precorrin-2 into siroheme (consisting of an oxidation and fe(2+) chelation) YP_001850191.1 thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane (export): so responsible for the translocation of the substrate across the membrane YP_001850192.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001850195.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001850196.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001850198.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001850199.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001850201.1 function unknown, induction by DNA damage YP_001850202.1 involved in active transport of SN-glycerol-3- phosphate across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001850203.1 involved in active transport of SN-glycerol-3- phosphate across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001850204.1 involved in carbohydrate transport and metabolism YP_001850205.1 thought to be involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system YP_001850206.1 enzyme that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. in M. tuberculosis it is regulated by SigH. [catalytic activity: NADPH + oxidized thioredoxin = NADP(+) + reduced thioredoxin] YP_001850207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001850212.1 function unknown but may be involved in trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway). seems to have additional alpha-glucosidase activity YP_001850214.1 function unknown, probably involved in cellular metabolism YP_001850220.1 phosphopantetheinyl transferase. secondary metabolites biosynthesis, transport, and catabolism. Sfp- type phosphopantetheinyl transferase YP_001850221.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001850222.1 possibly catalyzes the transfer of a great variety of lipids between membranes YP_001850223.1 function unknown, but involved in lipid degradation YP_001850224.1 involved in transcriptional mechanism YP_001850225.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001850226.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001850229.1 involved in mRNA degradation. hydrolyses single- stranded polyribonucleotides processively in the 3' to 5' direction. involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation [catalytic activity: RNA(n+1) + phosphate = RNA(N) + a nucleoside diphosphate] YP_001850230.1 function unknown; possibly hydrolyzes peptides and/or proteins YP_001850232.1 may play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [catalytic activity: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3) + NADH] YP_001850233.1 involved in transcriptional mechanism YP_001850236.1 thought to be involved in detoxification reactions following oxidative damage to lipids YP_001850237.1 function unknown, probably involved in cellular metabolism YP_001850239.1 function unknown, probably involved in cellular metabolism YP_001850242.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001850245.1 function unknown, contains a multimeric flavodoxin WrbA domain YP_001850249.1 function unknown, orthologues in mycobacteriophage YP_001850251.1 function unknown. may be involved in virulence YP_001850252.1 function unknown, but involved in lipid degradation YP_001850255.1 involved in long-chain fatty acid synthesis (at the first step). carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein] YP_001850257.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001850258.1 function unknown, but involved in lipid degradation YP_001850259.1 function unknown, but supposed involvement in lipid degradation YP_001850260.1 function unknown, probably involved in cellular metabolism YP_001850261.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001850262.1 essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dump to dTMP [catalytic activity: 5,6,7,8- tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH] YP_001850264.1 implicated in methylation of DNA. component of type I restriction/modification system. it is possible that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence YP_001850265.1 implicated in restriction/modification of DNA. component of type I restriction/modification system. it is thought that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence YP_001850266.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_001850267.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001850268.1 function unknown, belongs to the metallo-beta- lactamase superfamily YP_001850269.1 function unknown domain identity suggests this is a methylase involved in secondary metabolism (polyketides) YP_001850270.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001850272.1 possibly involved in cell division processes YP_001850273.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis YP_001850274.1 involved in acidic phospholipid biosynthesis. this protein probably catalyzes the committed step to the synthesis of the acidic phospholipids [catalytic activity: CDP-diacylglycerol + glycerol-3-phosphate = CMP + 3-(3- phosphatidyl)-glycerol 1-phosphate] YP_001850275.1 possibly involved in transcriptional mechanism YP_001850276.1 function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription YP_001850278.1 function unknown but contains a lima, limonene-1,2- epoxide hydrolase domain YP_001850279.1 function unknown, probably involved in cellular metabolism YP_001850282.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001850283.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001850284.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001850287.1 involved in signal transduction (via phosphorylation). thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001850291.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001850292.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001850293.1 possibly a GTPase, modulating activity of HflK and HflC proteins YP_001850294.1 function unknown, but involved in lipid metabolism YP_001850297.1 Represses a number of genes involved in the response to DNA damage YP_001850298.1 in M. tuberculosis H37Rv thought to be regulated by LexA YP_001850301.1 function unknown but contains identity to an epimerase involved in phenazine biosynthesis YP_001850302.1 function unknown, probably involved in cellular metabolism YP_001850304.1 function unknown but contains weak similarity to V8- like Glu-specific endopeptidases involved in amino acid transport and metabolism YP_001850305.1 catalyzes the conversion of NADPH to NADH YP_001850307.1 transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene YP_001850308.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase YP_001850314.1 function unknown but contains pfam01042 domain, endoribonuclease L-PSP. endoribonuclease active on single- stranded mRNA. inhibits protein synthesis by cleavage of mRNA. previously thought to inhibit protein synthesis initiation. this protein may also be involved I YP_001850316.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_001850317.1 catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. GTP, UTP and CTP can replace ATP as phosphoryl donor [catalytic activity: (phosphate)(N) + d-glucose = (phosphate)(N-1) + d-glucose 6-phosphate] YP_001850318.1 in E. coli, SuhB mutation (SuhB2) enhances the synthesis of sigma(32) and suppresses temperature- sensitive growth of the RpoH15 mutant. may affect some step(S) of protein synthesis by facilitating the function of GroE or other heat shock proteins YP_001850322.1 catalyzes the formation of dUMP from dUTP YP_001850327.1 part of a potassium transport system YP_001850328.1 part of a potassium transport system YP_001850329.1 function unknown but domain identity suggests a role in amino acid transport YP_001850330.1 function unknown but domain identity suggests this CDS encodes TrmA, a protein related to tRNA (uracil-5-)- methyltransferases YP_001850331.1 thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system YP_001850332.1 thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001850333.1 thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001850334.1 thought to be involved in transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001850335.1 thought to be involved in active transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001850337.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001850341.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001850342.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001850343.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_001850344.1 function unknown but contains identity to pfam06778, chlorite dismutase. this family contains chlorite dismutase enzymes of bacterial and archaeal origin. this enzyme catalyses the disproportionation of chlorite into chloride and oxygen. note that many family memb YP_001850346.1 function unknown but contains a SelR domain. these family of reductases are involved in the reduction of methionine sulfoxides in proteins YP_001850349.1 involved in riboflavin biosynthesis (at the second and third steps). converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH] YP_001850353.1 function unknown, possibly hydrolyzes peptides and/or proteins in presence of ATP YP_001850355.1 function unknown but has domain identity with lysophospholipases YP_001850357.1 thought to be involved in transport of amino acid across the membrane YP_001850360.1 involved in transport of arsenic compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001850361.1 involved in transcriptional mechanism YP_001850362.1 function unknown, in M. tuberculosis H37Rv this gene induced by cadmium (see hotter et al., 2001) YP_001850363.1 involved in transcriptional mechanism YP_001850365.1 it catalyses the conversion of hydrogen peroxide to water and molecular oxygen and is thus involved in the protection of cells from the toxic effects of peroxides YP_001850366.1 function unknown but contains identity with a pfam01740 STAS domain. the STAS (after sulphate transporter and antisigma factor antagonist) domain is found in the C terminal region of sulphate transporters and bacterial antisigma factor antagonists. it has been Sug YP_001850369.1 function unknown, but involved in lipid degradation YP_001850370.1 role in resistance to chloramphenicol. modifies the primary (C-3) hydroxyl of the antibiotic YP_001850374.1 function unknown but contains phosphoribosyltransferase domain YP_001850376.1 involved in lipid metabolism YP_001850383.1 methylation of unknown substrate YP_001850384.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane YP_001850385.1 involved in electron transfer YP_001850389.1 function unknown but contains pfam03060 domain, NPD, 2-nitropropane dioxygenase. members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor YP_001850393.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001850394.1 function unknown, but location and domain identity to hydrlases suggests it could be involved in lipid metabolism YP_001850395.1 catalyzes the transfer of a free alcohol (inositol) onto CDP-diacylglycerol. the product of this putative ORF seems be essential to mycobacteria [catalytic activity: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl 1D- myo-inositol] YP_001850396.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001850397.1 involved in the first mannosylation step in phosphatidylinositol mannoside biosynthesis (transfer of mannose residues onto pi, leading to the synthesis of phosphatidylinositol monomannoside) YP_001850398.1 function unknown but contains a NUDIX domain YP_001850399.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_001850400.1 function unknown, lipolytic enzyme involved in cellular metabolism. can hydrolyze a broad range of acyl- CoA thioesters YP_001850401.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_001850402.1 function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages YP_001850403.1 highly conserved protein YP_001850409.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001850411.1 function unknown, possible membrane protein YP_001850414.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001850415.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001850416.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001850419.1 function unknown, domain identity membrane protein Cdd COG3759 YP_001850422.1 function unknown, but involved in lipid degradation YP_001850423.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001850424.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001850425.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001850426.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001850427.1 function unknown. possible COG0747, DdpA, ABC-type dipeptide transport system, periplasmic component [amino acid transport and metabolism] YP_001850428.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001850429.1 involved in the metabolism of PPGPP (at the first step). in eubacteria PPGPP (guanosine 3'-diphosphate 5- 'diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. this enzyme catalyzes the formation of PPPGPP which is then hydrolysed to form PPGPP [catalytic activity: ATP + GTP = AMP + guanosine 3'- diphosphate 5-'triphosphate] YP_001850430.1 ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides] YP_001850431.1 involved in glyoxal pathway. thioesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2- hydroxy acid anion] YP_001850432.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001850433.1 In M. tuberculosis this CDS is REGULATED BY LexA YP_001850434.1 DNA integration - phage mediated YP_001850435.1 initiation of DNA replication for an episomal element YP_001850436.1 possible role in DNA segregation during cell division YP_001850437.1 function unknown, domain homology suggests role in initiation of plasmid replication YP_001850441.1 function unknown; possibly involved in transport of metal ions across the membrane YP_001850442.1 function unknown but contains a putative protein-S- isoprenylcysteine methyltransferase domain YP_001850443.1 involved in transcriptional mechanism. probably ArsR-family YP_001850444.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)] YP_001850448.1 function unknown; possibly involved in transport of metal ions across the membrane YP_001850449.1 function unknown; contains a possible alkaline phosphatase domain YP_001850450.1 function unknown YP_001850451.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)] YP_001850452.1 May be regulated by LexA YP_001850454.1 Contains patatin domain. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase.; patatin-like phospholipase catalysing the cleavage of fatty acids from membrane lipids YP_001850456.1 function unknown. contains Cdd pfam01381, HTH_3, helix-turn-helix of DNA binding proteins YP_001850457.1 contains partial (N-terminal) Cdd pfam00596, aldolase_II, class II aldolase and adducin N-terminal domain YP_001850458.1 involved in biosynthesis of diaminopimelate and lysine from aspartate semialdehyde (at the first step) [catalytic activity: l-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O] YP_001850461.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_001850462.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001850463.1 function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins YP_001850466.1 function unknown, but contains Cdd COG1305, transglutaminase-like enzymes, putative cysteine proteases YP_001850469.1 function unknown; possible proteolytic activity (cysteine protease) YP_001850472.1 function unknown, thought to be involved in the persistence in the host YP_001850474.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001850475.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001850477.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001850479.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001850480.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001850481.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001850482.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001850484.1 function unknown, hydrolyses peptides YP_001850485.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001850486.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001850488.1 function unknown. could be an ornithine/arginine/lysine decarboxylase involved in the biosynthesis of spermidine from arginine YP_001850489.1 function unknown, probably involved in cellular metabolism YP_001850491.1 function unknown YP_001850495.1 involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids YP_001850496.1 involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids YP_001850498.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_001850499.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001850500.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001850502.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001850503.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001850504.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001850506.1 Essential for recycling GMP and indirectly, cGMP YP_001850507.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001850508.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001850509.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001850511.1 function unknown, probably involved in cellular metabolism YP_001850515.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001850516.1 causes methylation YP_001850517.1 involved in transcriptional mechanism YP_001850518.1 causes methylation YP_001850519.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001850521.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001850522.1 involved in riboflavin biosynthesis (at the second and third steps). converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH] YP_001850523.1 involved in transport of aminoglycosides and tetracycline across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane YP_001850525.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001850526.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate YP_001850527.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001850530.1 In M. tuberculosis this CDS is REGULATED BY LexA YP_001850531.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001850534.1 involved in transcriptional mechanism YP_001850536.1 function unknown, but supposed involved in lipid metabolism YP_001850537.1 activates fatty acids by binding to coenzyme A YP_001850541.1 function unknown, probably involved in cellular metabolism YP_001850543.1 involved in second phase of glycolysis (first step) [catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.] YP_001850544.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001850545.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001850546.1 involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: 4-aminobutanoate + 2- oxoglutarate = succinate semialdehyde + L-glutamate] YP_001850547.1 thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane YP_001850548.1 possibly involved in transcriptional mechanism YP_001850550.1 involved in protein export. participates in a early event of protein translocation YP_001850551.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001850554.1 involved in pentose phosphate pathway. hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. [catalytic activity : 6-phospho-D-glucono-1,5-lactone + H(2)O = 6- phospho-D-gluconate] YP_001850555.1 may be involved in the functional assembly of glucose 6-phosphate dehydrogenase YP_001850556.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001850557.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate YP_001850558.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001850559.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001850560.1 involved in HemE and porphyrin biosynthesis (at the penultimate step). catalyzes the 6-electron oxidation of protoporphyrinogen ix to form protoporphyrin ix [catalytic activity: protoporphyrinogen-IX + O(2) = protoporphyrin-IX + H(2)O(2)] YP_001850561.1 involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway). seems to have additional alpha-glucosidase activity YP_001850562.1 involved in transcriptional mechanism YP_001850563.1 catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone] YP_001850565.1 thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001850566.1 thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001850567.1 thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system YP_001850569.1 involved in transcriptional mechanism YP_001850572.1 thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system YP_001850573.1 catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, l- selenocysteine, and L-selenocystine to produce L-alanine YP_001850574.1 function unknown, probably involved in cellular metabolism YP_001850577.1 function unknown, but involvement in lipid degradation YP_001850579.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly cadmium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)] YP_001850580.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions YP_001850581.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions YP_001850582.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001850583.1 probable macrolide-transport ATP-binding protein ABC transporter. thought to be involved in active transport of macrolide across the membrane YP_001850584.1 involved in transcriptional mechanism YP_001850585.1 involved in transcriptional mechanism YP_001850586.1 Catalyzes the conversion of citrate to isocitrate YP_001850588.1 similar to a hypothetical invasion protein. possibly an exported protein with unusually long signal sequence. NLP/P60 family protein YP_001850589.1 homology to cell wall-associated hydrolases. possibly an exported protein of the NLP/P60 family YP_001850590.1 involved in transcriptional mechanism YP_001850593.1 involved in the fatty acid biosynthesis pathway (first reduction step) (mycolic acid biosynthesis); reduces KasA/KasB products [catalytic activity: (3R)-3- hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl- [acyl-carrier protein] + NADPH] YP_001850594.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001850595.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001850597.1 function unknown. contains Cdd match to COG1585, COG1585, membrane protein implicated in regulation of membrane protease activity [posttranslational modification, protein turnover, chaperones / intracellular trafficking and secretion] YP_001850601.1 involved in transcriptional mechanism YP_001850602.1 contains N-terminal Cdd pfam00072, response_reg, response regulator receiver domain. this domain receives the signal from the sensor partner in bacterial two- component systems. it is usually found N-terminal to a DNA binding effector domain. C-terminal conatins Cdd pfam00486, trans_reg_C, transcriptional regulatory protein, C terminal YP_001850603.1 two-component system response sensor kinase contains Cdd pfam02518, hATPase_C, histidine kinase-, DNA gyrase B-, and Hsp90-like ATPase; Cdd pfam00512, HisKA, his kinase a (phosphoacceptor) domain. dimerisation and phosphoacceptor domain of histidine kinases YP_001850605.1 conserved membrane protein of unknown function. similar to proteins from many organisms containing Cdd COG0398; uncharacterized conserved protein [function unknown] YP_001850606.1 involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity: (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA] YP_001850607.1 MDM; functions in conversion of succinate to propionate YP_001850608.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_001850609.1 function unknown, but supposed involvement in lipid metabolism YP_001850610.1 function unknown. contains Cdd pfam07311, DUF1458, protein of unknown function (DUF1458). this family consists of several hypothetical bacterial proteins as well as one archaeal sequence. members of this family are typically of around 70 residues in length. the function of this family is unknown YP_001850613.1 involved in lipooligosaccharide biosynthesis [catalytic activity: UDP-glucose + 2 NAD+ + H2O = UDP- glucuronate + 2 NADH]. belongs to UDP-glucose/GDP-mannose dehydrogenase family YP_001850614.1 involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose] YP_001850615.1 contains Cdd pfam00535 glycosyl transferase. diverse family, transferring sugar from UDP-glucose, UDP-N- acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids YP_001850616.1 contains Cdd COG0451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane - carbohydrate transport and metabolism] YP_001850617.1 involved in the final assembly of the M. marinum LOS-IV glycolipid YP_001850618.1 function unknown YP_001850619.1 methylation of unknown substrate YP_001850620.1 involved in transcriptional mechanism YP_001850624.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_001850625.1 function unknown but contains left-handed parallel beta-helix, with 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[Stav]-X- [Liv]-[gaed]-X). proteins containing hexapeptide repeats are often enzymes showing acyl-transferase activity YP_001850632.1 function unknown role in carbohydrate metabolism YP_001850633.1 involved at the second step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: 7-phospho-3- deoxy-arabino-heptulosonate = 3-dehydroquinate + orthophosphate] YP_001850636.1 involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate] YP_001850637.1 function unknown. maybe involved in cell wall biogenesis YP_001850638.1 function unknown - may be involved in [cell envelope biogenesis by transfer of nucleotides onto phosphosugars YP_001850639.1 may be involved in regulation of cell wall biogenesis YP_001850640.1 possibly involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose] YP_001850644.1 synthesis of unknown metabolite. single module with the following domains: KS, ATP, ER, KR, ACP YP_001850645.1 activates fatty acids by binding to coenzyme A YP_001850646.1 thought to be involved in fatty acid transport YP_001850647.1 function unknown. contains a non-ribosomal peptide (Nrp) condensation domain. possibly involved in the synthesis of a hybrid NRP-PKS YP_001850648.1 function unknown, catalyzes the elongation of N- fatty acyl-CoA with methylamalonyl-CoA. single module with domain structure: KS, ATP, DH, ER, KR, ACP YP_001850650.1 function unknown; identity with NPD, 2-nitropropane dioxygenase. members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor YP_001850653.1 possibly involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall YP_001850654.1 function unknown, domain identity to UbiG, 2- polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylases YP_001850655.1 function unknown. contains Cdd pfam00535, glycos_transf_2, glycosyl transferase. diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids YP_001850657.1 function unknown. contains Cdd COG1819, glycosyl transferases, related to UDP-glucuronosyltransferase [carbohydrate transport and metabolism / signal transduction mechanisms] YP_001850658.1 function unknown. similarity to Cdd pfam03007. uncharacterised protein family (UPF0089). this family of uncharacterised proteins is greatly expanded in mycobacterium tuberculosis. the most conserved region of the proteins contains conserved histidine and aspartate residues suggesting a possible metal binding site suggestive of a protease activity YP_001850659.1 function unknown. thought to be involved in lipid metabolism YP_001850660.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_001850661.1 function unknown YP_001850662.1 function unknown. partial Cdd COG0030, KsgA, dimethyladenosine transferase (rRNA methylation) [translation, ribosomal structure and biogenesis] YP_001850663.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001850664.1 conversion of asparagine to aspartate YP_001850665.1 this protein specifically catalyzes the removal of signal peptides from prolipoproteins [catalytic activity : cleavage of N-terminal leader sequences from membrane prolipoproteins YP_001850666.1 pseudouridine synthase (pseudouridylate synthase) (uracil hydrolyase)[catalytic activity] uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O YP_001850667.1 function unknown. contains partial Cdd COG2226, UbiE, methylase involved in ubiquinone/menaquinone biosynthesis YP_001850668.1 function unknown YP_001850669.1 oxygen transport. this family of HemE binding proteins are found mainly in bacteria YP_001850670.1 thought to reduce acyl-CoA esters of fatty acids to fatty aldehydes YP_001850671.1 possibly involvement in lipid metabolism YP_001850673.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001850674.1 probably involved in lipid degradation YP_001850675.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001850676.1 function unknown YP_001850677.1 function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins YP_001850678.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_001850680.1 involved in transcriptional mechanism YP_001850681.1 involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) YP_001850682.1 involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) YP_001850683.1 possibly involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) YP_001850685.1 possible inv protein, probably exported as has QQAPV repeats at c-terminus YP_001850687.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_001850688.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_001850689.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001850691.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_001850695.1 function unknown, domain identity to ADP-ribose pyrophosphatases, possible role in nucleotide transport and metabolism YP_001850696.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001850697.1 catalyzes the formation of oxaloacetate from L-aspartate YP_001850698.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_001850700.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001850701.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001850702.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001850703.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001850704.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis YP_001850705.1 involved in inositol phosphate metabolism. it is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. key enzyme of the phosphatidyl inositol signaling pathway [catalytic activity: inositol 1(or 4)-monophosphate + H(2)O = inositol + orthophosphate] YP_001850706.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001850707.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_001850708.1 function unknown YP_001850710.1 function unknown, possibly involved in secondary metabolites biosynthesis, transport, and catabolism / inorganic ion transport and metabolism YP_001850711.1 catalyze the formation of cyanophycin which may act to store excess nitrogen YP_001850712.1 thought to be involved in transport of cationic amino acid (especially arginine and ornithine) across the membrane. responsible for the translocation of the substrate across the membrane YP_001850713.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001850714.1 involved in transport of ions (presumably calcium) across the membrane. responsible for the translocation of the substrate across the membrane YP_001850715.1 peroxide detoxification YP_001850716.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001850718.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001850719.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001850720.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001850721.1 prolipoprotein modification YP_001850724.1 hydrolysis of cutin YP_001850725.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001850726.1 involved in fatty acid metabolism YP_001850728.1 involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration). responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001850729.1 involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration). responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001850730.1 involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O] YP_001850731.1 involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O] YP_001850733.1 involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate] YP_001850734.1 sensor part of a two-component regulatory system YP_001850735.1 thought to be involved in lipid metabolism YP_001850737.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001850738.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001850739.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain YP_001850742.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001850743.1 thought to be involved in transport of drug across the membrane (export). drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells) YP_001850745.1 function unknown, domain identity to universal stress protein family and to iron-regulated conserved hypothetical protein TB15.3 from M. tuberculosis H37Rv YP_001850748.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001850749.1 involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001850752.1 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001850753.1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins YP_001850754.1 translation YP_001850755.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001850756.1 rRNA modification YP_001850761.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001850762.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001850764.1 function unknown YP_001850765.1 function unknown YP_001850767.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001850768.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_001850769.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001850770.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_001850771.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001850772.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001850773.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001850774.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001850775.1 possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2] YP_001850776.1 Has some homology to Pks12 required for mycoketide syntehsis YP_001850777.1 function unknown. contains acyl transferase, dehydratase, ketoreductase, and phosphopantetheine attachment site YP_001850779.1 possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2] YP_001850780.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001850781.1 thought to be involved in active transport of macrolide across the membrane (export). macrolide antibiotics resistance by an export mechanism. responsible for energy coupling to the transport system YP_001850782.1 wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-OXO acid + NH3 + H2O2] YP_001850783.1 activates fatty acids by binding to coenzyme A YP_001850785.1 role in amino acid transport and metabolism YP_001850788.1 thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane YP_001850790.1 thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane YP_001850791.1 thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for energy coupling to the transport system YP_001850792.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_001850793.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001850795.1 transposition of ISMyma06 YP_001850800.1 function unknown YP_001850803.1 function unknown; probably involved in cellular metabolism YP_001850805.1 has a contact-dependent haemolytic activity; possibly involved in virulence (pore formation) YP_001850806.1 catalyzes the phosphorylation of NAD to NADP YP_001850807.1 involved in recombinational repair of damaged DNA YP_001850810.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001850811.1 NUDIX hydrolases catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives YP_001850812.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001850813.1 catalyzes the O-methylation [catalytic activity: S- adenosyl-L-methionine + catechol = S-adenosyl-L- homocysteine + guaiacol] YP_001850814.1 this is a family of myo-inositol-1-phosphate synthases. inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. inositol phosphates play an important role in signal transduction YP_001850815.1 membrane associated. contains Cdd matches to polyprenyltransferase domains YP_001850816.1 contains Cdd COG1082,sugar phosphate isomerases/epimerases [carbohydrate transport and metabolism YP_001850817.1 contains Cdd COG1099, predicted metal-dependent hydrolases with the TIM-barrel FolD YP_001850818.1 function unknown; closest homologue NP_627450.1 hypothetical (41%ID over 169aa, expect = 3e-24) protein streptomyces coelicolor A3(2) (C-terminal) YP_001850819.1 function unknown YP_001850821.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001850824.1 production of unknown metabolite - contains two modules of: C, a (Phe) , T, E and C, a (arg),T, int te YP_001850825.1 thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins YP_001850826.1 function unknown, but involved in lipid degradation YP_001850829.1 function unknown, possible role in chromosome partioning YP_001850832.1 possible role in ribosome biogenesis and protein translation YP_001850833.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001850834.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001850835.1 transposition of ISMyma03 YP_001850836.1 transposition of ISMyma03 YP_001850838.1 function unknown. possibly a protective antigen involved with the early control of infection YP_001850840.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)] YP_001850843.1 function unknown, contains six NHL repeats. the NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. it is about 40 residues long and resembles the wd repeat pfam00400. the repeats may have a catalytic activity, proteolysis of one menber has shown that the peptidyl-alpha-hydroxyglycine alpha-amidating lyase (pal) activity is localised to the repeats. one member interacts with the activation domain of tat. this interaction is mediated by the NHL repeats YP_001850848.1 function unknown; domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide YP_001850849.1 transposition of ISMyma03 YP_001850850.1 transposition of ISMyma03 YP_001850854.1 this CDS encodes a 3-oxo-5-alpha-steroid 4- dehydrogenase. this family consists of 3-oxo-5-alpha- steroid 4-dehydrogenases. also known as steroid 5-alpha- reductase, the reaction catalysed by this enzyme is: 3-oxo- 5-alpha-steroid + acceptor <=> 3 YP_001850858.1 function unknown role in carbohydrate transport and metabolism YP_001850861.1 involved in transcriptional mechanism YP_001850864.1 function unknown but may be involved in inhibition of protein synthesis by cleavage of mRNA YP_001850865.1 involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of YP_001850867.1 function unknown, probably involved in cellular metabolism YP_001850869.1 the members of this family catalyse the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin YP_001850870.1 function unknown but contains signal peptide YP_001850871.1 function unknown but domain identity with penicillin V acylase and related amidases YP_001850872.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate YP_001850873.1 function unknown but contains signal peptide and domain identity with periplasmic component of the tol biopolymer transport system YP_001850875.1 involved in active transport of unknown sugars across the membrane. responsible for the translocation of the substrate across the membrane YP_001850876.1 function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages YP_001850877.1 involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001850879.1 metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)] YP_001850880.1 thought to be involved in transport amino acids across the membrane YP_001850882.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001850884.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001850885.1 part of a potassium transport system YP_001850886.1 function unknown but may play a role in protein translation YP_001850887.1 function unknown but contains signal peptide YP_001850888.1 transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation YP_001850890.1 involved in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds seven more isoprene units to omega,E, Z- farnesyl diphosphate and releases decaprenyl diphosphate YP_001850894.1 H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane YP_001850898.1 function unknown, but involved in lipid degradation YP_001850901.1 possibly involved in detoxification reactions following oxidative damage to lipids YP_001850902.1 domain: regulator of polyketide synthase expression YP_001850905.1 involved in transport of unknown substrate across the membrane YP_001850906.1 function unknown; probably involved in cellular metabolism YP_001850907.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001850909.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine YP_001850910.1 function unknown. possibly transporter involved in transport of undeterminated substrate (possibly cationic amino acids) across the membrane: so responsible for the translocation of the substrate across the membrane YP_001850911.1 interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]. this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor YP_001850913.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001850915.1 function unknown but some domain identity with Zn- dependent proteases YP_001850917.1 function unknown but domain identity suggests this CDS is Acs-like, acyl-coenzyme A synthetases/AMP-(fatty) acid ligases involved in lipid metabolism YP_001850918.1 domain identity suggests this CDS encodes an AraD- like, ribulose-5-phosphate 4-epimerase. this enzyme and related epimerases and aldolases are involved in carbohydrate transport and metabolism YP_001850919.1 function unknown role in cellular metabolism YP_001850921.1 function unknown but domain identity suggests it may be a signal-transduction protein YP_001850922.1 function unknown, lipolytic enzyme probably involved in cellular metabolism YP_001850923.1 function unknown; involved in cellular metabolism YP_001850924.1 function unknown, probably involved in cellular metabolism YP_001850926.1 activates fatty acids by binding to coenzyme A YP_001850928.1 function unknown; probably involved in cellular metabolism YP_001850931.1 function unknown but contains signal peptide YP_001850932.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001850933.1 function unknown - contains signal peptide YP_001850939.1 involved in transcriptional mechanism YP_001850941.1 could cause methylation of unknown substrate YP_001850942.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions YP_001850946.1 function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection YP_001850948.1 function unknown but contains aminopeptidase domain identity YP_001850949.1 function unknown, probably involved in cellular metabolism YP_001850952.1 involved in transcriptional mechanism YP_001850953.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001850954.1 involved in transcriptional mechanism YP_001850956.1 function unknown but this protein family are hydrolase enzymes YP_001850961.1 transfers a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan YP_001850963.1 function unknown but has multiple FtsK/SpoIIIE protein domains. this domain contains a putative ATP binding P-loop motif and is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE YP_001850964.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001850965.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001850976.1 function unknown proteolytic activity but subtilases are a family of serine proteases that can play a role in posttranslational modification YP_001850978.1 function unknown, but domain identity to aaa, ATPase family proteins that have been associated with chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes YP_001850985.1 thought to be involved in Mg2+ transport (import). may act as an accessory protein for MgtB so mediating magnesium influx into the cytosol [catalytic activity: ATP + H(2)O + mg(2+)(out) = ADP + phosphate + mg(2+)(in)] YP_001850986.1 function unknown, probably involved in cellular metabolism YP_001850987.1 function unknown - weak domain identity with lipase/esterase proteins YP_001850988.1 function unknown - weak domain identity with lipase/esterase proteins YP_001850989.1 involved in lipid desaturation YP_001850992.1 function unknown, probably involved in cellular metabolism YP_001850994.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001850995.1 valine and isoleucine biosynthesis (first step) [catalytic activity : 2-acetolactate + CO(2) = 2 pyruvate] YP_001850996.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins YP_001850997.1 thought to be involved in cardiolipin biosynthesis; generates cardiolipin from phosphatidylglycerol and CDP- diacylglycerol [catalytic activity : may be: phosphatidylglycerol + phosphatidylglycerol -> cardiolipin + glycerol, or: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate] YP_001851001.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001851002.1 function unknown but contains an FHA domain. these domains are involved in nuclear signalling domain and may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine YP_001851003.1 function unknown but high N-terminal domain identity with the MerR helix-turn-helix transcription regulator YP_001851005.1 function unknown but contains MerR helix-turn-helix transcription regulatory domain YP_001851006.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001851008.1 may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide] YP_001851010.1 function unknown but weak C-term identity with vWA domain (von willebrand factor type a domain). this domain is found in extracellular proteins, like integrins, and mediates adhesion YP_001851011.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_001851013.1 function unknown - however contains domain identity with TlyC - representative of hemolysins and related proteins containing Cbs domains. Cbs domains are small intracellular modules of unknown function. they are mostly found in 2 or four copies within a protein YP_001851014.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001851015.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001851016.1 function unknown but significant domain identity with HtpX, Zn-dependent protease with chaperone function YP_001851017.1 involved in transcriptional mechanism YP_001851018.1 function unknown but domain identity suggests possibly involved in aromatic compound catabolism YP_001851019.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_001851020.1 involved in the conversion of UreA to NH3 [catalytic activity: UreA + H2O = CO2 + 2 NH3] YP_001851021.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_001851022.1 required for the insertion of the nickel ion at the active site of the urease protein YP_001851023.1 UreG is required for functional incorporation of the urease nickel metallocenter. it is not known whether UreG binds GTP or some other nucleotide YP_001851024.1 UreD is involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex and is required for urease nickel metallocenter assembly YP_001851025.1 transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation YP_001851026.1 function unknown, probably involved in cellular metabolism YP_001851027.1 function unknown, probably involved in cellular metabolism YP_001851028.1 involved in the active transport of molybdenum into the cell across the membrane (import). part of the binding- protein-dependent transport system ModABC YP_001851029.1 part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for the translocation of the substrate across the membrane YP_001851030.1 function unknown, but possible involved in lipid metabolism YP_001851031.1 function unknown but shows high identity with sulfide-quinone reductase from chlorobium tepidum YP_001851033.1 part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for energy coupling to the transport system YP_001851034.1 function unknown could mediate bacterial attachment to host cells YP_001851036.1 catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD YP_001851039.1 bacterial enzyme that splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-p and/or acetyl-P and glyeraldehyde-3-p YP_001851040.1 function unknown, probably involved in cellular metabolism YP_001851041.1 function unknown but contains acetyltransferase domain identity YP_001851042.1 function unknown, but possible involvement in lipid metabolism YP_001851043.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001851044.1 function unknown but contains nucleoside- diphosphate-sugar epimerase domain identity - a domain associated with cell envelope biogenesis, carbohydrate transport and metabolism YP_001851048.1 function unknown but probably plays a role in posttranslational protein modification, turnover and chaperone functions YP_001851049.1 involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C] YP_001851050.1 involved in trehalose biosynthesis (protective effect). converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) YP_001851051.1 involved in oxidative stress response YP_001851052.1 involved in oxidative stress response YP_001851056.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001851057.1 function unknown but like upstream ORF, contains bacterioferritin-associated ferredoxin domain YP_001851058.1 involved in iron storage (may perform analogous functions in iron detoxification and storage as that of animal ferritins); ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited YP_001851060.1 involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate] YP_001851062.1 function unknown; involved in cellular metabolism YP_001851063.1 involved in lipid metabolism. single module of C, a (Phe or trp), T, C domains YP_001851065.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001851067.1 function unknown, probably involved in cellular metabolism YP_001851069.1 thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis YP_001851070.1 catalyzes the interconversion of chorismate to prephenate YP_001851071.1 function unknown, probably involved in cellular metabolism YP_001851072.1 function unknown, probably involved in cellular metabolism YP_001851074.1 involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity YP_001851078.1 function unknown but some similarity with YceI-like family proteins. in E. coli YceI is a base-induced periplasmic protein. its function has not yet been characterised YP_001851079.1 generates aldehyde or ketone from alcohol [catalytic activity: alcohol + NADP(+) = aldehyde or ketone + NADPH] YP_001851080.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001851086.1 function unknown; involved in cellular metabolism YP_001851087.1 function unknown, probably involved in cellular metabolism YP_001851088.1 function unknown but significant domain identity with O-Methyltransferases involved in polyketide biosynthesis YP_001851089.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001851091.1 Truncated wrt to orthologues, missing last 12aa - potential pseudogene; function unknown but contains predicted phosphatase domain YP_001851093.1 CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation YP_001851094.1 transport of sialic acid across the membrane. responsible for the translocation of the substrate across the membrane YP_001851098.1 wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-OXO acid + NH3 + H2O2] YP_001851105.1 function unknown; contains putative metal-dependent hydrolase domain YP_001851107.1 involved in transcriptional mechanism YP_001851108.1 function unknown, probably involved in cellular metabolism YP_001851109.1 thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle YP_001851111.1 involved in transcriptional regulation YP_001851116.1 involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate] YP_001851123.1 function unknown, lipolytic enzyme probably involved in cellular metabolism YP_001851126.1 involved in transcriptional mechanism YP_001851128.1 involved in transcriptional mechanism YP_001851130.1 activates fatty acids by binding to coenzyme A YP_001851134.1 16 kDa immunogenic extracellular protein): function unknown YP_001851135.1 thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate] YP_001851137.1 function unknown - domain identity suggests Na+- dependant transporter YP_001851139.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway. YP_001851140.1 alkyl hydroperoxidase; catalyze the reduction of hydrogen peroxide to water and the reduction of alkyl hydroperoxides to the corresponding alcohols YP_001851141.1 function unknown: involved in carbohydrate transport and metabolism YP_001851144.1 function unknown; probably involved in cellular metabolism YP_001851146.1 function unknown but has weak indentity with hydrolase domains YP_001851147.1 function unknown but contains dihydrofolate reductase domain YP_001851150.1 involved in transcriptional mechanism YP_001851154.1 function unknown but domain identity with Fe-S oxidoreductases YP_001851155.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001851156.1 function unknown, but supposed involvement in lipid degradation YP_001851157.1 function unknown, but supposed involvement in lipid degradation YP_001851158.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001851159.1 function unknown, probably involved in cellular metabolism YP_001851160.1 function unknown, may be involved in electron transfer YP_001851161.1 this enzyme acts on epoxides (alkene oxides, oxiranes) and Arene oxides. plays a role in xenobiotic metabolism by degrading potential toxic epoxides. also determines steady-state levels of physiological mediators YP_001851162.1 function unknown, probably involved in cellular metabolism YP_001851163.1 involved in riboflavin biosynthesis [catalytic activity : GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy- 4-(5-phosphoribosylamino)pyrimidine + diphosphate] YP_001851164.1 function unknown, probably involved in cellular metabolism YP_001851167.1 maybe required for the translocation of the substrate across the membrane YP_001851168.1 involved in transcriptional mechanism; repression of the Mce3 operon. could also have a regulatory action on the Mce2 operon YP_001851170.1 thought to oxidize a wide variety of aliphatic and aromatic aldehydes YP_001851171.1 function unknown but weak domain identity with two- component response regulators YP_001851172.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001851173.1 function unknown, domain identity with ketosteroid isomerase-related proteins YP_001851176.1 function unknown, but probably part of Mce3 operon and member of YrbE family YP_001851177.1 function unknown, but thought to be involved in host cell invasion YP_001851178.1 function unknown, but thought to be involved in host cell invasion YP_001851179.1 function unknown, but thought to be involved in host cell invasion YP_001851180.1 function unknown, but thought to be involved in host cell invasion YP_001851181.1 function unknown, but thought to be involved in host cell invasion YP_001851182.1 function unknown, but thought involved in host cell invasion YP_001851191.1 function unknown - possible role in cell-wall biogenesis YP_001851192.1 function unknown: some similarity to pMUM CDS, hypothetical protein MUP016c YP_001851193.1 function unknown; some similarity to MUP015c from pMUM001 YP_001851195.1 this protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis YP_001851197.1 possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls YP_001851201.1 function unknown but some domain identity with Zn- dependent proteases YP_001851202.1 function unknown; contains serine proteinase inhibitors (serpin) domain homology YP_001851203.1 hydrolysis of cutin (a polyester that forms the structure of plant cuticle) YP_001851207.1 high-affinity uptake of glycine betaine. supposed responsible for the translocation of the substrate across the membrane YP_001851208.1 multifunctional enzyme, exhibiting both a catalase, a broad-spectrum peroxidase, and a peroxynitritase activities. may play a role in the intracellular survival of mycobacteria within macrophages; protection against reactive oxygen and nitrogen intermediates produced by phagocytic cells. seems regulated by SigB [catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O] YP_001851209.1 acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene YP_001851212.1 may be a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate] YP_001851214.1 adds the distal cyclopropane ring to alpha-meroacid in mycolic acid biosynthesis. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase YP_001851216.1 methylation of unknown substrate YP_001851218.1 methylation of unknown substrate YP_001851220.1 function unknown; possible role in deamination [amino acid transport and metabolism] YP_001851221.1 function unknown; contains a putative glyoxalase domain YP_001851224.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001851225.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably the reductase required for cytochrome P-450 function YP_001851226.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably the reductase required for cytochrome P-450 function YP_001851228.1 hydrolysis of cutin YP_001851230.1 function unknown, but involved in lipid degradation YP_001851232.1 function unknown, probably involved in cellular metabolism YP_001851233.1 possibly involved in transcriptional mechanism YP_001851235.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001851236.1 function unknown YP_001851239.1 amino acid transport and metabolism YP_001851241.1 possibly has helicase activity YP_001851243.1 function unknown. secreted protein YP_001851244.1 thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle YP_001851245.1 contains a C-term cellobiohydrolase a (1,4- beta-cellobiosidase a) domain and a N-term cellulose- binding domain (CBD) domain. the CBD is found either at the N-term or at the C-term of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases YP_001851247.1 function unknown. possible secreted protein YP_001851248.1 function unknown; probably involved in cellular metabolism, probably electron-transfer-linked YP_001851250.1 function unknown but in E. coli PemK is a growth inhibitor known to bind to the promoter region of the PEM operon, auto-regulating synthesis YP_001851252.1 function unknown; probably involved in cellular metabolism YP_001851253.1 function unknown, belongs AcrR family of transcriptional regulators YP_001851255.1 involved in transcriptional mechanism YP_001851256.1 function unknown role in cellular metabolism. contains predicted signal peptide sequence YP_001851257.1 function unknown, but probably involved in sugar or lipid transport. contains a C-term patatin-like phospholipase domain. the patatin family consists of various patatin glycoproteins from plants. the patatin protein accounts for up to 40% of the total soluble protein in potato tubers. patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. this predicted protein also contains multiple membrane-spanning domains and a beta-barrel structure, characteristic of pore-forming membrane proteins YP_001851258.1 involved in NAD metabolism [coenzyme metabolism] YP_001851259.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001851264.1 methylation of unknown substrate YP_001851265.1 function unknown but contains a sugar isomerase N- term domain and N and C-term predicted beta-barrels YP_001851266.1 function unknown YP_001851267.1 could possibly oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3- hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001851268.1 function unknown YP_001851269.1 function unknown; contains a putative flavoprotein domain YP_001851270.1 function unknown; possible role in cleavage of unknown acyl-ACP substrate YP_001851271.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001851272.1 involved in transcriptional mechanism YP_001851273.1 function unknown; contains flavin-utilizing monoxygenase domain YP_001851274.1 function unknown; thought to be involved in lipid biosynthesis [catalytic activity: androstan-3-alpha,17- beta-diol + NAD+ = 17-beta-hydroxyandrostan-3-one + NADH] YP_001851276.1 function unknown; contains two universal stress protein family domains. the universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general 'stress endurance' activity YP_001851277.1 involved in transcriptional mechanism YP_001851278.1 involved in the degradation of biphenyl [catalytic activity: biphenyl-2,3-diol + O(2) = 2-hydroxy-6-OXO-6- phenylhexa-2,4-dienoate + H(2)O] YP_001851279.1 isomerizes HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) to ohed (2-OXO-hept-3-ene-1,7-dioate) YP_001851280.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate YP_001851283.1 involved in transcriptional regulation (repression) of heat shock proteins E.G. DnaK, GrpE, DnaJ. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock YP_001851284.1 function unknown. may be involved in a chaperoning process YP_001851285.1 involved in the biosynthesis of tetrahydrofolate (at the first step) [catalytic activity: GTP + 2 H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)DiHYD ro pteridine triphosphate] YP_001851287.1 involved in electron transfer YP_001851288.1 function unknown. possibly involved in signal transduction mechanisms YP_001851290.1 the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released YP_001851291.1 function unknown. possibly involved in lipid metabolism YP_001851303.1 thought to be involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system YP_001851305.1 thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001851308.1 converts amides such as nicotinamide to corresponding acid YP_001851310.1 function unknown, in general gluconate kinase catalyzes the phosphoryl transfer from ATP to gluconate. the resulting product gluconate-6-phosphate is an important precursor of gluconate metabolism YP_001851312.1 converts unknown esters to corresponding free acid and alcohol YP_001851317.1 required for mycoketide synthesis YP_001851320.1 transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis YP_001851321.1 transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis YP_001851322.1 domain identity with predicted metal-dependent hydrolases with the TIM-barrel folds YP_001851323.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_001851324.1 domain identity with dienelactone hydrolases YP_001851327.1 function unknown. domain identity to ThiJ-like intracellular proteases/amidases YP_001851329.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism YP_001851332.1 cellular metabolism YP_001851334.1 function unknown. contains adenylate cyclase domain YP_001851337.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate YP_001851338.1 involved in cobalamin biosynthesis YP_001851340.1 thought to be involved in fatty acid transport YP_001851342.1 hydrolyses beta-lactams to generate corresponding beta-amino acid [catalytic activity: a beta-lactam + H(2)O = a substituted beta-amino acid] YP_001851343.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001851344.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 YP_001851345.1 involved in cobalamin biosynthesis YP_001851365.1 hydrolysis of peptide bonds YP_001851366.1 involved in DNA metabolism YP_001851368.1 DNA helicase activity YP_001851369.1 involved in proteins export: required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K. this sec-independent pathway is termed tat for twin- arginine translocation system YP_001851370.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001851372.1 contains domain homology to transcriptional regulators YP_001851374.1 protein degradation YP_001851375.1 protein degradation YP_001851384.1 involved in transfer of methyl group (from S- adenosyl-L-methionine to a substrate) YP_001851385.1 has significant domain identity to RecB family exonucleases YP_001851387.1 Nrp of 5 modules. domain structure (C, a, T) X 5, ending in a te domain. metabolite produced unknown YP_001851388.1 a single module PKS, with the following domain structure when linked with U/S and D/S ORFs: (KS, ATProp, DH, ER, KR, ACP) YP_001851389.1 production of unknown metabolite. this CDS encodes a single NRP and PKS module with domain structure: (KS, Ata, DH, ER, KR, ACP) YP_001851390.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001851391.1 Enables the enzymatic reduction of mercuric ions to elemental mercury YP_001851393.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001851394.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_001851398.1 function unknown, probably involved in cellular metabolism YP_001851400.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001851401.1 involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H] YP_001851402.1 may help control the pool of 3'-PHOSPHOADENOSIDE 5'- phosphosulfate, or its use in sulfite synthesis (by similarity) YP_001851406.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001851410.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001851412.1 function unknown but contains bacterial/archael phosphatidylethanolamine-binding (PEBP) domain YP_001851413.1 function unknown - but has domain identity with cetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases [amino acid transport and metabolism] YP_001851414.1 site-specific integration of bacteriophage DNA YP_001851415.1 function unknown, signficant identity with putative plasmid replication initiator protein [streptomyces coelicolor A3(2)] YP_001851416.1 possible role in phage DNA replication. the FtsK/SpoIIIE family contains a putative ATP binding P-loop motif. it is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE, which has roles in regulation of prespore specific gene expression in B. subtilis. a mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. the SpoIIIE protein is implicated in intercellular chromosomal DNA transfer YP_001851419.1 may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair YP_001851421.1 function unknown, reaction: catalysis of the alpha,beta dehydrogenation of the corresponding trans- enoyl-CoA YP_001851422.1 activates fatty acids by binding to coenzyme A YP_001851423.1 function unknown, contains a transglutaminase/protease-like domain; transglutaminases are enzymes that establish covalent links between proteins YP_001851424.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001851425.1 function unknown; probably involved in cellular metabolism YP_001851426.1 function unknown role in lipid metabolism YP_001851427.1 function unknown; probably involved in cellular metabolism YP_001851428.1 function unknown; involved in cellular metabolism YP_001851431.1 could be involved in transcriptional mechanism YP_001851432.1 function unknown; contains hydrolase domain YP_001851433.1 could be involved in transcriptional mechanism YP_001851437.1 transposition of the insertion sequence ISMyma01 YP_001851438.1 transposition of the insertion sequence ISMyma01 YP_001851439.1 thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH] YP_001851440.1 activates fatty acids by binding to coenzyme A YP_001851442.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001851443.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001851444.1 involved in electron transfer and energy coupling reactions. probably part of an operon including the P450 and ferrodoxin reductase gene products YP_001851445.1 involved in transcriptional mechanism YP_001851446.1 probably involved in a transcriptional mechanism YP_001851447.1 function unknown; contains predicted hydrolase or acyltransferase domain (alpha/beta hydrolase superfamily YP_001851448.1 function unknown YP_001851449.1 involved in transcriptional mechanism YP_001851450.1 function unknown but contains domain identity with acetyl-CoA acetyltransferase domain, thus possible involvement in lipid metabolism YP_001851454.1 function unknown; contains DNA-binding domain YP_001851456.1 orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form dim YP_001851458.1 thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins YP_001851459.1 function unknown. thought to be involved in fatty acid transport YP_001851461.1 production of unknown peptide. contains 5 predicted modules of domain organiszation:Amt, CAMT, cat, cat, CAMT int te. the 'A' domain substrates have not been accurately predicted but probably Phe, Thr or ala) YP_001851462.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001851463.1 function unknown but contains lysophospholipase domain YP_001851466.1 function unknown but corresponds to antigen 84 of mycobacterium tuberculosis (Wag31) (see hermans et al., 1995). predicted to contain significant amount of coiled coil structure YP_001851471.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001851472.1 this protein may be involved in septum formation (by similarity) YP_001851473.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001851474.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001851475.1 function unknown function in cell division YP_001851476.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001851477.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001851478.1 involved in cell wall formation; peptidoglycan biosynthesis YP_001851479.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001851481.1 involved in peptidoglycan biosynthesis YP_001851484.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001851486.1 function unknown but contains acyl-CoA N- acyltransferase superfamily domain YP_001851489.1 involved in lipid biosynthesis YP_001851492.1 involved in signal transduction (via phosphorylation) YP_001851493.1 involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths YP_001851494.1 part of the mevalonate pathway for isoprenoid synthesis: conversion: acetyl-CoA + H(2)O + acetoacetyl- CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + CoA YP_001851495.1 HMGR is a tightly regulated enzyme, which catalyzes the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. in mammals, this is the rate limiting committed step in cholesterol biosynthesis. bacteria, such as pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3- hydroxy-3-methylglutaryl-CoA YP_001851496.1 part of the mevalonate pathway for isoprenoid synthesis. possible regulatory role in mevalonate metabolism. converts (R)-5-phosphomevalonate to (R)-5- diphosphomevalonate YP_001851497.1 key enzyme in isoprenoid synthesis. converts (R)-5- diphosphomevalonate to phosphate + isopentenyl diphosphate + CO(2) YP_001851498.1 converts (R)-mevalonate to (R)-5-phosphomevalonate (ATP dependant) YP_001851499.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_001851500.1 involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths YP_001851501.1 function unknown but possibly involved in catalysis of cyclisation cascades involving polyisoprene substrates YP_001851502.1 involved in fatty acid biosynthesis. catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl- acp. kas III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. possesses both acetoacetyl-acp synthase and acetyl transacylase activities [catalytic activity: acyl- [acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]] YP_001851503.1 involved in chorismate biosynthesis YP_001851507.1 transfer of fatty acyl groups YP_001851509.1 function unknown but domain identity suggests it is an anion-transporting ATPase YP_001851512.1 function unknown, but involved in lipid metabolism YP_001851517.1 contains 3'-5'exonuclease domain YP_001851518.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001851519.1 thought to be involved in aerobic respiration YP_001851520.1 plays a role in aerobic respiration YP_001851521.1 role in respiration YP_001851522.1 role in respiration YP_001851526.1 involved in aerobic respiration. subunit I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE a and cu(a) to the binuclear center formed by HemE A3 and cu(B) (by similarity) YP_001851527.1 asparagine biosynthesis YP_001851528.1 phosphorylation of carbohydrates YP_001851530.1 function unknown but domain identity shows similarity to the HesB gene (function unknown) but which is expressed only under nitrogen fixation conditions YP_001851531.1 function unknown role in carbohydrate transport and metabolism YP_001851533.1 involved in cobalamin biosynthesis YP_001851534.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_001851535.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_001851536.1 function unknown but domain identity with chloride channel superfamily YP_001851537.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001851538.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001851540.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001851541.1 thought to be involved in detoxification reactions following oxidative damage to lipids YP_001851542.1 involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2 YP_001851543.1 function unknown but domain identity with NAD dependent sugar epimerases YP_001851544.1 function unknown role in substrate movement YP_001851545.1 probably involved in active transport of substrate across the membrane (export). responsible for energy coupling to the transport system YP_001851546.1 thought to be involved in fatty acid transport YP_001851548.1 thought to be involved in fatty acid transport YP_001851550.1 involved in lipid metabolism. nine ext. modules, each module with predicted domain structure of C,a,T, domains ending in an integral te domain YP_001851551.1 synthesis of unknown metabolite. predicted structure: two extension modules, each with C, a & T domains. possible Thr & arg substrate YP_001851552.1 synthesis of unknown peptide - four predicted extension modules, each with domain structure C, a & T. final extension module End with an integral te domain. predicted, respective substrate specificity for each module: ThrE, Orn-D, arg, ThrE YP_001851553.1 activates fatty acids by binding to coenzyme A YP_001851554.1 function unknown; contains a phosphopantetheine attachment site, thus probably plays a role in this Nrp operon, perhaps for synthesis of a NRP/PKS fusion YP_001851557.1 the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released YP_001851561.1 function unknown, may have methyltransferase activity YP_001851562.1 involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate] YP_001851564.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001851565.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001851566.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001851567.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001851570.1 involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate] YP_001851571.1 function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection YP_001851572.1 function unknown, probably involved in cellular metabolism YP_001851574.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001851575.1 involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate] YP_001851576.1 function unknown; thought to hydrolyze peptides and/or proteins YP_001851577.1 cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C] YP_001851578.1 function unknown; thought to hydrolyze peptides and/or proteins YP_001851580.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001851584.1 function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages YP_001851588.1 involved in cobalamin biosynthesis YP_001851590.1 involved in signal transduction (via dephosphorylation). can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0 [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate YP_001851591.1 function unknown: may be involved in the ability to survive in macrophages YP_001851592.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_001851594.1 function unknown; possibly involved in transport of metal ions across the membrane YP_001851595.1 function unknown; contains high domain identity with epoxide hydrolases. they comprise a group of functionally related enzymes that catalyse the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. in animals, the major interest in eh is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three- membered ring system and the strong polarisation of the C-- O bonds. this is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. this family is often found in conjunction with pfam00561 YP_001851596.1 transposition of ISMyma07 YP_001851598.1 transposition of ISMyma07 YP_001851600.1 function unknown; probably involved in cellular metabolism YP_001851601.1 involved in transcriptional mechanism YP_001851602.1 function unknown; contains a putative glyoxylase domain YP_001851603.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide] YP_001851604.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide] YP_001851605.1 function unknown YP_001851609.1 oxido-reduction YP_001851612.1 detoxification of organic peroxides YP_001851614.1 N-term truncated (missing first 69aa) compared to M. tuberculosis YP_001851615.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001851617.1 catalyzes malonyl-CoA-acp transacylase (McaT) activity using holo-AcpM as substrate for transacylation [catalytic activity: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein] YP_001851618.1 carries the fatty acid chain in fatty acid biosynthesis YP_001851619.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001851620.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001851621.1 involved in fatty acid biosynthesis (mycolic acids synthesis) [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl- CoA] YP_001851623.1 involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor] YP_001851624.1 possibly involved in transcriptional regulation YP_001851625.1 electron acceptor YP_001851626.1 involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids YP_001851630.1 possibly involved in transcriptional regulation YP_001851631.1 oxido-reduction YP_001851633.1 transposition of insertion sequence element ISMyma02 YP_001851634.1 function unknown YP_001851635.1 Predicted to be involved in lipoprotein acylation YP_001851636.1 oxidoreduction YP_001851638.1 function unknown YP_001851642.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001851643.1 possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]. must have important function in metabolism. supposed involved in stationary- phase survival YP_001851645.1 function unknown YP_001851650.1 function unknown YP_001851651.1 function unknown, in general, cation channels are transport proteins responsible for the movement of cations through the membrane YP_001851652.1 function unknown; predicted hydrolase (had superfamily) domain YP_001851653.1 transposition of the insertion sequence ISMyma01 YP_001851654.1 transposition of the insertion sequence ISMyma01 YP_001851657.1 contains PTPS, 6-pyruvoyl tetrahydropterin synthase domain. 6-pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6- pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. the functional enzyme is a hexamer of identical subunits YP_001851661.1 transposition of an insertion sequence YP_001851665.1 function unknown but contains identity with hydroxylase domain YP_001851667.1 Involved in synthesis of cell wall components that are required to inhibit phagosome maturation YP_001851668.1 domain identity with beta-lactamase class C and other penicillin binding proteins YP_001851669.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001851670.1 function unknown role in lipid metabolism YP_001851675.1 function unknown; probably involved in cellular metabolism YP_001851679.1 involved in signal transduction (via phosphorylation). thought to regulate phosphate transport. can phosphorylate the peptide substrate myelin basic protein (MBP) at serine and threonine residues. can be autophosphorylated on threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001851680.1 function unknown, possibly involved in cell wall biosynthesis. contains a putative beta-lactamase domain YP_001851682.1 metabolism of malonate YP_001851683.1 function unknown; member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins YP_001851685.1 function unknown; contains a N-term serine/threonine protein kinases, catalytic domain and two C-term WD40 domains. WD40 domains are found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the wd dipeptide at its c-terminus and is 40 residues long, hence the name WD40 YP_001851687.1 unknown function YP_001851688.1 function unknown; probably involved in cellular metabolism YP_001851689.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001851690.1 role in pyruvate metabolism. reaction: ATP + pyruvate + H(2)O <=> AMP + phosphoenolpyruvate + phosphate YP_001851691.1 involved in glycolysis; converts sugar-1-P to sugar- 1,6-P [catalytic activity: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate] YP_001851693.1 function unknown; probably involved in cellular metabolism YP_001851695.1 involved in phosphate transport YP_001851696.1 generates nitrite from ammonia using oxidized ferredoxin [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin]. the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur- containing amino acids and cofactors YP_001851697.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001851700.1 generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH] YP_001851701.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001851703.1 function unknown. possibly involved in transcriptional mechanism YP_001851706.1 function unknown; contains putative acyltransferase domain YP_001851708.1 function unknown but contains zinc binding domain found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone YP_001851709.1 hydrolysis of lipids (bound ester) YP_001851712.1 transposition of of ISMyma04 YP_001851713.1 function unknown, probably involved in cellular metabolism YP_001851717.1 possibly involved in transport of Na+/H+ across the membrane YP_001851718.1 involved in transcriptional mechanism YP_001851719.1 function unknown but contains identity with hydroxylase domain YP_001851720.1 function unknown but contains oxidoreductase domain YP_001851725.1 involved in phospholipid biosynthesis [catalytic activity: CDP-diacylglycerol + H(2)O = CMP + phosphatidate] YP_001851736.1 could help control the pool of 3'-PHOSPHOADENOSIDE 5'-phosphosulfate, or its use in sulfite synthesis (by similarity) YP_001851739.1 potential pseudogene YP_001851746.1 may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide] YP_001851747.1 initiates the elongation in type II fatty acid synthase systems. elongation of fatty acids in the type II systems occurs by claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA YP_001851748.1 initiates the elongation in type II fatty acid synthase systems. elongation of fatty acids in the type II systems occurs by claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA YP_001851751.1 function unknown; contains universal stress protein UspA domain - possible nucleotide-binding protein invloved in signal transduction mechanism YP_001851752.1 function unknown. contains universal stress protein UspA domain - possible nucleotide-binding protein involved in signal transduction mechanisms YP_001851753.1 sensor part of a two-component regulatory system YP_001851754.1 regulator part of a two-component regulatory system YP_001851755.1 function unknown. could play a role in in the phosphorelay of the two-component regulatory system YP_001851756.1 phosphofructokinase and related sugar kinases play an important role in the predominant pathway for fructose utilisation YP_001851757.1 function unknown but contains N-term phosphoribosyltransferase domain and C-term eythromycin esterase YP_001851758.1 thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR YP_001851762.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001851763.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide] YP_001851764.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide] YP_001851765.1 involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2 YP_001851766.1 function unknown; may act as an acyl carrier protein YP_001851768.1 function unknown YP_001851770.1 function unknown: homology to ,Fe-hydrogenase maturation factor YP_001851771.1 function unknown role in energy production and conversion YP_001851773.1 function unknown; involved in electron transfer YP_001851774.1 electron transfer YP_001851777.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)] YP_001851779.1 function unknown; probably involved in cellular metabolism YP_001851781.1 involved in transcriptional mechanism YP_001851784.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001851787.1 cellular metabolism YP_001851788.1 function unknown, probably involved in cellular metabolism, possibly electron transfer YP_001851789.1 possibly involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) YP_001851790.1 thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O] YP_001851791.1 involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase YP_001851792.1 involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase YP_001851793.1 probably involved in a transcriptional mechanism YP_001851795.1 molecular chaperone YP_001851796.1 involved in transcriptional mechanism YP_001851799.1 function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis YP_001851800.1 function unknown but contains metal-dependant hydrolase domain identity YP_001851803.1 function unknown; probably involved in cellular metabolism YP_001851806.1 function unknown but high domain identity with O- Methyltransferases involved in polyketide biosynthesis YP_001851808.1 function unknown, but high domain identity with epimerases and phenazine biosynthesis-like protein, PhzC/PhzF which is involved in dimerisation of two 2,3- dihydro-3-oxo-anthranilic acid molecules to create Pca by P. fluorescens YP_001851811.1 function unknown but has ribonuclease I domain identity YP_001851813.1 conserved membrane protein of unknown function. similar to proteins from many organisms containing Cdd COG0398; uncharacterized conserved protein [function unknown] YP_001851814.1 function unknown but domain identity with mechanosensitive ion channels YP_001851815.1 function unknown but contains multiple functional domains including vWA domain (von willebrand factor (vWF) type a domain; found in extracellular proteins, like integrins, and mediates adhesion. also contains a vault protein inter-alpha-trypsin domain YP_001851817.1 involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB YP_001851819.1 involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]. N-term resembles PknK from MTB YP_001851821.1 function unknown but contains glutamine synthetase catalytic domain YP_001851825.1 function unknown, probably involved in cellular metabolism YP_001851826.1 function unknown. possibly transporter involved in transport of undeterminated substrate (possibly cationic amino acids) across the membrane: so responsible for the translocation of the substrate across the membrane YP_001851827.1 function unknown, high domain identity with saccharopine dehydrogenase. this family comprises three structural domains that can not be separated in the linear sequence. in some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate YP_001851828.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_001851829.1 involved in transcriptional mechanism YP_001851830.1 function unknown, high domain identity with BioA, aminotransferase [coenzyme metabolism] YP_001851831.1 function unknown - possible oxidoreducatse YP_001851832.1 possibly involved in transcriptional mechanism YP_001851833.1 function unknown, probably involved in cellular metabolism YP_001851836.1 catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone] YP_001851837.1 hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)] YP_001851838.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate] YP_001851846.1 function unknown; contains two OpuBC, periplasmic glycine betaine/choline-binding (LipO)protein domains of an ABC-type transport system (osmoprotectant binding protein) YP_001851847.1 function unknown; domain identity with lactoylglutathione lyase YP_001851855.1 DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes YP_001851866.1 may be part of a phage restriction modification system YP_001851867.1 may be involved in phage replication YP_001851868.1 involved in chromosome structure and partitioning. essential for chromosome partition. part of phage replication machinery YP_001851869.1 part of phage replication machinery YP_001851870.1 function unknown; may have ATPase activity YP_001851872.1 part of a plasmid or prophage maintenance system for killing segregants. weak identity with a putative killer suppression protein HigA from Methylococcus capsulatus str. Bath YP_001851873.1 ensures cells expressing the corresponding protein toxin are not killed YP_001851874.1 probably involved in phage replication. may play a role in DNA helix relaxation YP_001851876.1 DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes YP_001851878.1 function unknown. thought to be involved in fatty acid transport YP_001851881.1 metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)] YP_001851887.1 thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001851888.1 thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001851889.1 thought to be involved in active transport of sugar across the membrane (import) YP_001851891.1 thought to be involved in transport of cationic amino acid (especially arginine and ornithine) across the membrane. responsible for the translocation of the substrate across the membrane YP_001851892.1 involved in arginine metabolism [catalytic activity: L-ornithine + a 2-OXO acid = L-glutamate 5- semialdehyde + an L-amino acid] YP_001851894.1 involved in transcriptional mechanism YP_001851896.1 probably involved in active transport accross the membrane. thought to be responsible for energy coupling to the transport system and the translocation of the substrate across the membrane YP_001851898.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001851901.1 function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein YP_001851902.1 tryptophan halogenase catalyses the chlorination of tryptophan to form 7-chlorotryptophan. this is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. tryptophan halogenase is NADH-dependent YP_001851904.1 function unknown but contains 3 modules for the potential synthesis of a tripeptide YP_001851905.1 function unknown; probably involved in cellular metabolism YP_001851906.1 probably involved in transport of undeterminated substrate (possibly cations Na/H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane YP_001851907.1 function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis YP_001851908.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane YP_001851910.1 decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [catalytic activity: formate + NAD(+) = CO(2) + NADH] YP_001851911.1 thought to play an essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'- cyclic AMP + pyrophosphate] YP_001851913.1 thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane YP_001851914.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001851916.1 involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L-cysteine + acetate] YP_001851917.1 involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine] YP_001851918.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions YP_001851919.1 function unknown, contains N-term signal peptide indicative of secreted protein YP_001851921.1 synthesizes RNA primers at the replication forks YP_001851922.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_001851927.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate] YP_001851928.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate] YP_001851938.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001851939.1 involved in transcriptional mechanism YP_001851940.1 acts as a global negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes YP_001851942.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001851943.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001851944.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_001851945.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001851950.1 function unknown but contains tetracycline repressor-like C-terminal superfamily domain YP_001851951.1 function unknown but contains alpha/beta-hydrolase superfamily domain YP_001851953.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001851954.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001851955.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_001851957.1 function unknown but contains identity with antioxidant defence protein Ahp YP_001851958.1 the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. belongs to the sigma-70 factor family, ECF subfamily YP_001851959.1 function not known (putative secreted protein); may play a role in the development of protective immune responses YP_001851960.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this peptide synthase forms amide bound between the carboxylic acid of salicylate and the alpha-amino group of serine (serine/threonine ligation) YP_001851961.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. activates amino acid residues that are incorporated into mycobactin (ligation) YP_001851962.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. probably activates the two lysine residues that are incorporated into mycobactin (lysine ligation) YP_001851963.1 function unknown but contains acyl-CoA N- acetyltransferase superfamily domain YP_001851964.1 may be required for the addition of the terminal aa in this Nrp operon YP_001851965.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins YP_001851966.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins YP_001851967.1 thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins YP_001851968.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this hydroxylase is possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly [catalytic activity: L-lysine + O(2) = N6-hydroxy- L-lysine + H(2)O. no information can be found if this enzyme is NADPH dependent or independent] YP_001851969.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins (initiation step of mycobactin chain growth). activates the mycobactin ACP in two half-reactions: activates salicylic acid as acyladenylate (adenylation step) + transfers activated salicylate to the MbtA ACP as a thioester (arylation step) YP_001851970.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly YP_001851972.1 function unknown but contains ferritin/ribonucleotide reductase-like superfamily domain YP_001851973.1 function unknown; involved in cellular metabolism YP_001851974.1 function unknown. possibly involved in transcriptional mechanism YP_001851975.1 catalyzes the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O] YP_001851977.1 catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function YP_001851980.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001851981.1 generates nitrite from ammonia using oxidized ferredoxin [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin]. can also act as a sulphite reductase. the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur-containing amino acids and cofactors. this appears to be the only intact nitrite reductase in M. ulcerans YP_001851982.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001851983.1 function unknown but contains a chelatase superfamily domain. given the presence of other heme- associated CDS in this region and the presence of a chelatase superfamily domain, this CDS may encode a ferrochelatase, catalyzing the last step in HemE biosynthesis YP_001851984.1 plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione [catalytic activity: 5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid] YP_001851985.1 function unknown but domain identity suggests a role in transporting oligopeptides as signals across the membrane YP_001851986.1 involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for energy coupling to the transport system YP_001851987.1 involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for the translocation of the substrate across the membrane YP_001851988.1 involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for the translocation of the substrate across the membrane YP_001851989.1 involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import) YP_001851991.1 function unknown, probably involved in cellular metabolism YP_001851995.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001851996.1 function unknown but domain identity with plasmid maintenance toxin superfamily YP_001851997.1 function unknown but contains 2 Cbs domains YP_001851998.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_001852001.1 function unknown but based on domain identity it may cross-link proteins through an acyl-transfer reaction between the gamma-carboxamide group of peptide-bound glutamine and the epsilon-amino group of peptide-bound lysine YP_001852003.1 function unknown but contains two glutathione synthetase ATP-binding superfamily domain-like sequences YP_001852004.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001852005.1 possible role in DNA replication. two superfamily domains detected. N-term contains P-loop nucleoside triphosphate hydrolase. C-term contains DNA polymerase III, delta subunit YP_001852006.1 function unknown, predicted membrane metal-binding protein YP_001852007.1 function unknown but domain identity suggests ComEA. a family of DNA uptake protein and related DNA- binding proteins involved in DNA replication, recombination, and repair YP_001852008.1 function unknown, but probable involvement in lipid metabolism YP_001852009.1 function unknown, but supposed involvement in lipid metabolism YP_001852010.1 function unknown but contains FAD/NAD(P)-binding superfamily domain YP_001852011.1 supposed involved in intracellular survival. possibly associated with the cell surface and secreted YP_001852012.1 function unknown but contains superfamily NAD(P)- binding Rossmann-fold domains YP_001852015.1 function unknown. thought to be involved in lipid transport YP_001852016.1 function unknown, contains DegV-like superfamily domain YP_001852017.1 function unknown but contains esterase/acetylhydrolase superfamily domain YP_001852018.1 involved in glycolysis [catalytic activity: 2- phosphoglycerate + 2,3-diphosphoglycerate = 3- phosphoglycerate + 2,3-diphosphoglycerate] YP_001852020.1 involved in NAD biosynthesis; catalyzes the reversible adenylation of nicotinate mononucleotide [catalytic activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+)] YP_001852022.1 function unknown but contains a von willebrand factor type a conserved domain YP_001852023.1 function unknown but contains aaa ATPase domain containing von willebrand factor type a (vWA) domain YP_001852024.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001852026.1 generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp YP_001852027.1 function unknown but domain identity suggests that it may be a mechanosensitive (ms) ion channel protein with a C-term putative cyclic nucleotide (camp or cGMP) binding domain YP_001852028.1 generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp YP_001852030.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001852031.1 function unknown, involved in transcriptional mechanism YP_001852032.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852033.1 function unknown. possibly involved in transcriptional mechanism YP_001852035.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001852036.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001852037.1 involved in the peptidyltransferase reaction during translation YP_001852038.1 involved in translation mechanisms YP_001852039.1 thought to be involved in several cellular process YP_001852040.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001852042.1 conversion of folates to polyglutamate derivatives. bacteria require folate for the biosynthesis of glycine, methionine, formyl-met-tRNA, thymidylates, purines, and pantothenate [catalytic activity: ATP + {tetrahydrofolyl- [Glu]}(N) + L-glutamate = ADP + phosphate + {tetrahydrofolyl-[Glu]}(n+1)] YP_001852043.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001852044.1 function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain YP_001852046.1 function unknown but contains potential saccharopine-like dehydrogenase domain YP_001852047.1 thought to promote the resuscitation and growth of dormant, nongrowing cells. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis YP_001852049.1 production of unknown peptide. Predict 3 modules with domain structure (C-A-M-T, C-A-T, C) YP_001852051.1 Single copy element; transposition of an insertion sequence (IS110 family) YP_001852052.1 Single copy element; transposition of an ISMyma01-like element YP_001852053.1 transposition of an ISMyma01-like element YP_001852054.1 Single copy element; transposition of an IS3 family insertion sequence YP_001852056.1 function unknown but this protein family are hydrolase enzymes - isochorismatase is an enzyme that catalyzes the conversion of isochorismate to 2,3- dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond YP_001852057.1 single copy element; transposition of an IS110 family insertion sequence YP_001852058.1 single copy element. maybe a partial IS as C-term subunit tranposase is absent.; transposition of an insertion sequence YP_001852060.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate] YP_001852061.1 polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, Ata, DH, KR, ACP YP_001852062.1 polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, ATP, DH, KR, ACP YP_001852063.1 polyketide synthase involved in lipid synthesis. three extension modules, domain arrangement: KS, Ata, DH, ER, KR, ACP; KS ATP, KR, ACP; KS ATP, DH, KR, ACP YP_001852064.1 polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, Ata, DH, KR, ACP YP_001852065.1 function unknown role, perhaps as an acyltransferase or condensase in prodction of secondary metabolite from this locus. this locus is predicted to produce a Nrp:PKS fusion. the PKS product is an apolar hexaketide YP_001852066.1 MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis YP_001852067.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin YP_001852068.1 function unknown, probably involved in cellular metabolism YP_001852069.1 thought to be involved in transport of undeterminated substrate (possibly sugar) across the membrane. responsible for the translocation of the substrate across the membrane YP_001852070.1 binds and unfolds substrates as part of the ClpXP protease YP_001852071.1 thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane YP_001852072.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001852073.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001852074.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001852075.1 function unknown, lipolytic enzyme involved in cellular metabolism YP_001852077.1 hydrolyses DNA (this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents) YP_001852078.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_001852079.1 involved in the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane. responsible for the translocation of the substrate across the membrane YP_001852080.1 function unknown but contains a DSBA-like thioredoxin domain YP_001852082.1 aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates) YP_001852085.1 function unknown but contains McrA, restriction endonuclease domain YP_001852086.1 oxygen carrier, involved in oxygen transport YP_001852087.1 involved in sugar metabolism (hydrolysis of terminal, non-reducing 1,4-linked d-glucose residues with release of d-glucose) YP_001852088.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate] YP_001852089.1 involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)] YP_001852090.1 thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane YP_001852091.1 involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD) YP_001852093.1 function unknown but some identity with thioesterase domains YP_001852094.1 catabolic GlutDH involved in the utilization of glutamate and other amino acids of the glutamate family. generates 2-oxoglutarate from L-glutamate [catalytic activity: L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH] YP_001852095.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001852096.1 function unknown but may play a role in DNA replication, recombination, and repair YP_001852097.1 involved in lipid desaturation YP_001852098.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001852099.1 N-terminus: could be generate serine and phosphate from phosphoserine; may catalyze the last step in the biosynthesis of serine from carbohydrates (the reaction mechanism could be proceed via the formation of a phosphoryl-enzyme intermediates) [catalytic activity 1: phosphoserine + H(2)O = serine + phosphate]. mid-section: involved in phospholipid biosynthesis (at the second step); converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [catalytic activity 2: acyl-CoA + 1-acyl-SN- glycerol 3-phosphate = CoA + 1,2-diacyl-SN-glycerol 3- phosphate]. c-terminus: contains tola protein domain homology. may serve to anchor this protein in the cm YP_001852100.1 function unknown but N-term contains a CoA- dependanant acyltransferase domain YP_001852101.1 function unknown, lipolytic enzyme involved in cellular metabolism YP_001852102.1 hydrolyzes cutin YP_001852104.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001852107.1 involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase YP_001852108.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide] YP_001852109.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide] YP_001852110.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide] YP_001852111.1 interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate] YP_001852112.1 function unknown but contains a central MaoC, acyl dehydratase domain YP_001852113.1 function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein YP_001852114.1 this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein] YP_001852115.1 involved in fatty acid metabolism YP_001852116.1 involved in various degradation and synthesis [catalytic activity: succinyl-CoA + a 3-OXO acid = succinate + a 3-OXO-acyl-CoA] YP_001852117.1 involved in fatty acid degradation/synthesis [catalytic activity: succinyl-CoA + a 3-OXO acid = succinate + a 3-OXO-acyl-CoA] YP_001852118.1 function unknown, but involved in lipid degradation YP_001852119.1 involved in transcriptional mechanism YP_001852122.1 function unknown, possibly involved in cellular metabolism YP_001852123.1 transposition of ISMyma04 YP_001852124.1 function unknown but contains ATPase domain YP_001852125.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001852127.1 involved in transcriptional mechanism YP_001852128.1 function unknown, YrbE family protein that is similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component YP_001852129.1 function unknown but similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component YP_001852130.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria YP_001852131.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria YP_001852132.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria YP_001852133.1 function unknown, but thought to be involved in host cell invasion YP_001852134.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria YP_001852135.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria YP_001852142.1 member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins YP_001852155.1 function unknown; contains a fibronectin type 3 domain YP_001852163.1 may be involved in phage capsid construction YP_001852168.1 function unknown - possible role in phage replication YP_001852178.1 involved in transcriptional mechanism YP_001852185.1 function unknown; possible role in phage DNA restriction modification system YP_001852186.1 function unknown; homology suggests possible regulatory protein YP_001852189.1 probably involved in phage genome replication. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. this DNA polymerase also exhibits 3' to 5' exonuclease activity. the beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA [catalytic activity: N deoxynucleoside triphosphate = N diphosphate + {DNA}n] YP_001852190.1 Possible role in phage replication. Domain identity with rect family. The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, Erf and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways YP_001852206.1 function unknown; putative role in regulation of transcription YP_001852210.1 contains a DNA binding domain. possibly involved in transcriptional mechanism YP_001852213.1 integration of phage genome into host chromosome YP_001852216.1 function unknown but domain identity suggests PlsC, phosphate acyltransferase. these enzymes function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2- acylglycerolphosphoethanolamine acyltransferase activities YP_001852219.1 putative antioxidant protein YP_001852220.1 deacetylates acetylornithine and hydrolyses N- acetylmethionine YP_001852221.1 involved in unknown signal transduction mechanism YP_001852222.1 regulator part of the two-component regulatory system YP_001852224.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001852225.1 involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH YP_001852227.1 may act to bind either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to a cytochrome C or cytochrome F haem iron YP_001852228.1 thought to oxidize a wide variety of aliphatic and aromatic aldehydes YP_001852229.1 function unknown role in lipid metabolism; contains a thioesterase/thiol ester dehydratase-isomerase superfamily domain YP_001852230.1 function unknown but like D/S ORF it contains a thioesterase/thiol ester dehydrase-isomerase superfmaily domain YP_001852232.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852233.1 function unknown, possibly involved in transport of drug across the membrane. contains AraJ, arabinose efflux permease domain identity YP_001852234.1 function unknown, probably involved in cellular metabolism. contains domain identity to phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases YP_001852235.1 contains an NRP-like adenylation domain YP_001852236.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001852237.1 function unknown but contains acyl-CoA transferases/carnitine dehydratase domain homology YP_001852238.1 involved in transcriptional mechanism YP_001852239.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852240.1 thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane YP_001852242.1 function unknown, but involved in lipid degradation YP_001852243.1 function unknown, but involved in lipid degradation YP_001852244.1 function unknown, but supposed involvement in lipid degradation YP_001852245.1 function unknown role in lipid metabolism YP_001852246.1 function unknown, but involved in lipid degradation YP_001852249.1 function unknown but contains a ricin-type beta- trefoil domain YP_001852250.1 function unknown. possibly involved in transcriptional mechanism YP_001852254.1 may be involved in regulation of SigG YP_001852255.1 function unknown, but involved in lipid degradation YP_001852256.1 function unknown, but supposed involvement in lipid degradation YP_001852259.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852260.1 thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH] YP_001852261.1 function unknown, probably involved in cellular metabolism YP_001852262.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852263.1 key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.] YP_001852265.1 function unknown; contains full length of an uncharacterized homolog of a gamma-carboxymuconolactone decarboxylase subunit YP_001852266.1 function unknown, probably involved in cellular metabolism YP_001852267.1 function unknown but contains a Ntf2-like superfmaily domain YP_001852269.1 function unknown but contains thioesterase/thiol ester dehydrase-isomerase superfmaily domain YP_001852270.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence YP_001852271.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852273.1 function unknown, but involved in lipid degradation YP_001852274.1 function unknown, but involved in lipid degradation YP_001852276.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence YP_001852278.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001852281.1 involved in transcriptional mechanism YP_001852282.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001852284.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001852285.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001852286.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001852287.1 function unknown, but supposed involvement in lipid degradation YP_001852288.1 involved in lipid degradation YP_001852289.1 function unknown, but involved in lipid degradation YP_001852291.1 possibly involved in transcriptional mechanism YP_001852292.1 function unknown, but involved in lipid degradation YP_001852293.1 function unknown, but supposed involvement in lipid degradation YP_001852294.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001852295.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001852296.1 function unknown, but involved in lipid metabolism [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF] YP_001852297.1 function unknown but contains a protein-kinase superfamily domain YP_001852298.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001852299.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001852302.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001852304.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001852308.1 involved in energy metabolism; contributes to acetyl-CoA production as part of pyruvate dehydrogenase complex [catalytic activity: pyruvate + lipoamide = S- acetyl-dihydro-lipoamide + CO(2)] YP_001852309.1 involved in transcriptional mechanism YP_001852313.1 function unknown, but thought to be involved in host cell invasion YP_001852314.1 function unknown, but thought to be involved in host cell invasion YP_001852315.1 function unknown, but thought to be involved in host cell invasion YP_001852316.1 function unknown, but thought to be involved in host cell invasion YP_001852317.1 function unknown, but thought to be involved in host cell invasion YP_001852318.1 function unknown, but thought involved in host cell invasion YP_001852320.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001852321.1 function unknown; contains a C-term rhomboid-family domain. these proteins contain three strongly conserved histidines in the putative transmembrane regions that may be involved in peptidase functions YP_001852324.1 function unknown; contains signal peptide YP_001852326.1 function unknown but domain identity suggests this CDS encodes a metal-dependent protease of the Pad1/Jab1 superfamily YP_001852327.1 function unknown, probable role in amino acid hydrolysis YP_001852329.1 function unknown but contains a ClpS domain suggesting a function related to ATP-dependent protein degradation YP_001852330.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_001852331.1 probable helicase involved in DNA repair and perhaps also replication YP_001852332.1 catalytic activity : {(1,4)-alpha-D-glucosyl}(N) + phosphate = {(1,4)-alpha-D-glucosyl}(N-1) + alpha-D- glucose 1-phosphate YP_001852333.1 function unknown, may be involved in polysaccharide degradation YP_001852334.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001852335.1 transposition of ISMyma04 YP_001852336.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions YP_001852337.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001852338.1 glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway YP_001852339.1 function unknown but contains a predicted nuclease domain of the RecB family YP_001852340.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate] YP_001852341.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate] YP_001852342.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate] YP_001852343.1 involved in damage reversal and in base excision repair. the methylated Ada protein acts as a positive regulator of its own synthesis, as well as that of other proteins. the transcription-activating function of the Ada protein resides in its N-terminus. repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated. can also repair O-4- methylthymine [catalytic activity: DNA (containing 6-O- methylguanine) + [protein]-L-cysteine = DNA (without 6-O- methylguanine) + protein S-methyl-L-cysteine] YP_001852344.1 repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated [catalytic activity : DNA (containing 6-O-methylguanine) + [protein]-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.] YP_001852345.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001852346.1 these proteins convert inactive cobalamins to AdoCbl for 1,2-propanediol degradation YP_001852348.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001852349.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001852350.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001852351.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001852352.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001852353.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001852354.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001852355.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001852357.1 catalysis of the first step of the lipid cycle reactions in the biosynthesis of cell wall peptidoglycan YP_001852358.1 function unknown but contains YrdC domain. this domain has been shown to preferentially bind to dsRNA YP_001852359.1 function unknown but may have S-adenosyl-methionine- dependent methyltransferase activity YP_001852360.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001852361.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001852362.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001852363.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001852364.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001852365.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_001852366.1 involved in biosynthesis of lysine (last step) [catalytic activity : meso-2,6-diaminoheptanedioate = L- lysine + CO(2)] YP_001852367.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001852368.1 transposition of ISMyma05 YP_001852372.1 this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor YP_001852373.1 pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate YP_001852374.1 function unknown but contains YCII-related protein domain YP_001852375.1 catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide YP_001852376.1 cleaves xaa-pro-releasing N-terminal dipeptides YP_001852377.1 function unknown but belongs to the TetR family of bacterial transcriptional regulatory proteins YP_001852379.1 function unknown, belongs to the LysR family of transcriptional regulators YP_001852380.1 function unknown role in transport. belongs to the DMT superfamily YP_001852382.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate] YP_001852387.1 NUDIX hydrolases catalyze the hydrolysis of a variety of nucleoside diphoshate derivatives YP_001852388.1 function unknown but contains TrkA domain. this domain is found in a wide variety of proteins. these protein include potassium channels P31069, phosphoesterases Q59027, and various other transporters. this domain binds to NAD YP_001852390.1 function unknown, probably involved in cellular metabolism YP_001852391.1 catalyzes the first step of the glyoxal pathway YP_001852392.1 function unknown but contains glyoxalase/bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily domain YP_001852394.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis YP_001852395.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001852396.1 function unknown, contains a thioesterase superfamily domain YP_001852397.1 domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide YP_001852398.1 involved in active transport of oligopeptide across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001852399.1 involved in active transport of oligopeptide across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001852400.1 involved in active transport of oligopeptide across the membrane (import). responsible for energy coupling to the transport system YP_001852401.1 involved in active transport of oligopeptide across the membrane (import). this protein is a component of the oligopeptide permease, a binding protein-dependent transport system; it binds peptides up to five amino acids long with high affinity YP_001852402.1 function unknown but contains alpha/beta-hydrolase superfamily domain YP_001852403.1 function unknown, probably involved in cellular metabolism, probably electron-transfer-linked YP_001852404.1 function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain YP_001852405.1 function unknown: possible role in DNA replication, recombination, and repair YP_001852406.1 function unknown, possible role in signal transduction YP_001852409.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001852410.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001852417.1 involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB YP_001852418.1 involved in signal transduction (via phosphorylation). in M. tuberculosis thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001852420.1 interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate] YP_001852422.1 could be implicated in several pathways involving acetyl-CoA. E.G. acetyl-CoA hydrolase from yeast catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) produces succinyl-CoA, and acetate-CoA transferase utilizes acyl-CoA and acetate to form acetyl-CoA YP_001852423.1 function unknown, but involved in lipid degradation YP_001852424.1 hydrolyses glycerophosphodiesters such as glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol) YP_001852427.1 glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway YP_001852431.1 involved in signal transduction (via phosphorylation) [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001852432.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001852433.1 involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001852434.1 function unknown. seems to be expressed during macrophage infection YP_001852435.1 possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate] YP_001852436.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001852438.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_001852442.1 function unknown, probably involved in cellular metabolism YP_001852444.1 thought to be involved in transport of undeterminated substrate (possibly macrolide) across the membrane (export). responsible for the translocation of the undeterminated substrate across the membrane YP_001852445.1 function unknown, probably involved in cellular metabolism YP_001852446.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852447.1 involved in transcriptional mechanism YP_001852451.1 catalyzes the acylation of the mycaminose sugar during midecamycin biosynthesis YP_001852452.1 has a helix-destabilizing activity YP_001852455.1 thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane YP_001852457.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth YP_001852458.1 function unknown, supposed involved in cellular metabolism YP_001852460.1 catalizes the oxidative decarboxylation of malate into pyruvate, important for a wide range of metabolic pathways [catalytic activity: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH] YP_001852461.1 catalyzes the oxidation of malate to oxaloacetate YP_001852462.1 thought to be involved in transport of magnesium and cobalt ions across the membrane. responsible for the translocation of the substrate across the membrane YP_001852463.1 catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor YP_001852464.1 involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane YP_001852466.1 involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system YP_001852467.1 involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001852468.1 involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001852469.1 thought to be involved in active transport of sugar across the membrane (import) YP_001852472.1 thought to be involved in Mg2+ transport. responsible for the translocation of the substrate across the membrane YP_001852475.1 function unknown: thought to be an ATP-binding protein YP_001852476.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_001852477.1 possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residue) YP_001852479.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence YP_001852480.1 function unknown, involved in cellular metabolism YP_001852482.1 involved in transcriptional mechanism YP_001852483.1 thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system YP_001852484.1 thought to be involved in active transport of tetronasin across the membrane (export): tetronasin resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001852488.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001852489.1 function unknown; probably involved in cellular metabolism YP_001852491.1 involved in base excision repair. hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions YP_001852494.1 involved in dihydrofolate biosynthesis [catalytic activity : 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate] YP_001852495.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization YP_001852498.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate YP_001852499.1 function unknown, probably involved in cellular metabolism YP_001852505.1 involved in transcriptional mechanism YP_001852506.1 activates fatty acids by binding to coenzyme A YP_001852509.1 oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH] YP_001852514.1 involved in transcriptional mechanism YP_001852515.1 oxidizes proline to glutamate for use as a carbon and nitrogen source [catalytic activity: L-proline + acceptor + H2O = (S)-1-pyrroline-5-carboxylate + reduced acceptor] YP_001852516.1 involved in the arginase pathway [catalytic activity: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O = L- glutamate + NADH] YP_001852517.1 may be a regulatory protein YP_001852521.1 involved in secretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane YP_001852522.1 could help control the pool of 3'-PHOSPHOADENOSIDE 5'-phosphosulfate, or its use in sulfite synthesis (by similarity) YP_001852523.1 ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity [catalytic activity 1: ATP + sulfate = diphosphate + adenylylsulfate] and APS kinase catalyzes the synthesis of activated sulfate [catalytic activity 2: ATP + adenylylsulfate = ADP + 3'- phosphoadenylylsulfate]. first and second steps in the sulfate activation pathway. these reactions occurs early in the reductive branch of the cysteine biosynthetic pathway YP_001852524.1 involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids YP_001852526.1 function unknown - possible Na+/H+ antiporter YP_001852527.1 ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms YP_001852529.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane YP_001852531.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane YP_001852537.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis YP_001852538.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001852540.1 catalyzes the NADP-dependent reduction of 2,4- dienoyl-CoA to yield trans-2- enoyl-CoA [catalytic activity: TRANS-2,3-didehydroacyl-CoA + NADP(+) = trans, TRANS-2,3,4,5-tetradehydroacyl-CoA + NADPH] YP_001852541.1 TB8.4; function unknown function (secreted protein) YP_001852543.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis YP_001852545.1 function unknown -possibly a transmembrane protein YP_001852546.1 involved in mycothiol biosynthesis. 1-D-myo- inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins)is converted to 1-D-myo-inosityl-2-amino-2- deoxy-alpha-D-glucopyranoside (GlcN-Ins) by this enzyme. seems to possesse weak mycothiol conjugate ami YP_001852547.1 involved in transcriptional mechanism YP_001852550.1 function unknown, probably interacts with the ribosomes in a GTP dependent manner YP_001852551.1 involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool. 8-OXO-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to at to Gc transversions. mutt specifically degrades 8-OXO-dGTP to the monophosphate YP_001852552.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction YP_001852553.1 involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis YP_001852561.1 function unknown, but supposed involved in lipid metabolism YP_001852562.1 involved in transcriptional mechanism YP_001852563.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_001852565.1 involved in transcriptional mechanism YP_001852566.1 function unknown. thought to be involved in fatty acid transport YP_001852568.1 function unknown, supposed involved in cellular metabolism YP_001852569.1 required for bile acid synthesis and for catabolism of branched-chain fatty acids YP_001852570.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001852574.1 ortholog of pks10; possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2] YP_001852576.1 function unknown; probably involved in cellular metabolism YP_001852578.1 oxidize fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001852579.1 function unknown, but involved in lipid degradation [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA] YP_001852583.1 oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH] YP_001852584.1 single copy element; transposition of an IS110 family element YP_001852587.1 involved in transcriptional mechanism YP_001852588.1 function unknown, possibly involved in cellular metabolism YP_001852589.1 function unknown, contains NADH-flavin reductase domain YP_001852590.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001852593.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001852596.1 thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol] YP_001852597.1 involved in transcriptional mechanism YP_001852599.1 supposed involved in detoxification reactions YP_001852600.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_001852601.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001852615.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001852617.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001852619.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001852620.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001852621.1 function unknown, probably involved in cellular metabolism YP_001852625.1 function unknown; possible carboxylesterase type B (lipid metabolism) domain YP_001852629.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001852630.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001852633.1 probably involved in carbohydrate degradation. may hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non- carbohydrate moiety YP_001852636.1 thought to catalyze the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O] YP_001852637.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001852638.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001852642.1 catalyzes the first committed step in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds one isoprene unit to omega,E- geranyl diphosphate. in mycobacterium YP_001852643.1 potential role involved in virulence YP_001852647.1 mycothiol-dependent detoxification enzyme, involved in mycothiol biosynthesis YP_001852649.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001852650.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_001852652.1 thought to be involved in homocysteine transulfuration [catalytic activity: L-serine + L- homocysteine = cystathionine + H2O] YP_001852653.1 hydrolyses lipids YP_001852655.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001852657.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA YP_001852658.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001852672.1 thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate] YP_001852674.1 activates fatty acids by binding to coenzyme A YP_001852677.1 function unknown; contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential YP_001852680.1 involved in transcriptional mechanism YP_001852682.1 the glycine cleavage system catalyzes the degradation of glycine [catalytic activity: (6S)- tetrahydrofolate + s-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein] YP_001852683.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_001852684.1 function unknown; involved in cellular metabolism YP_001852685.1 involved in transcriptional mechanism YP_001852687.1 function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis YP_001852688.1 involved in transcriptional mechanism YP_001852689.1 function unknown; probably involved in cellular metabolism, probably electron-transfer-linked YP_001852690.1 may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide] YP_001852691.1 thought to be involved in fatty acid transport YP_001852692.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852695.1 function unknown; domain identity suggests BtaA, s- adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase - with a potential role in methylation during lipid biosynthesis YP_001852704.1 integration of phage genome into host DNA YP_001852705.1 phage DNA recombination function YP_001852717.1 sensor part of the two-component regulatory system TrcS/TrcR. involved in transcriptional autoactivation: TrcR activates its own expression by interacting with the AT-rich sequence of the TrcR promoter YP_001852718.1 sensor part of the two-component regulatory system TrcS/TrcR YP_001852719.1 function unknown, possibly involved in amino acid transport and metabolism YP_001852721.1 function unknown; identity to GppA, exopolyphosphatase [nucleotide transport and metabolism / inorganic ion transport and metabolism] YP_001852724.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001852726.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001852727.1 involved in nucleotide excision repair. necessary for strand-specific repair. a lesion in the template strand blocks the RNA polymerase complex (RNAP). the RNAP- DNA-RNA complex is specifically recognized by TrcF which releases RNAP and the truncated transcript; the TcrF may replace RNAP at the lesion site and then recruit the UvrA/B/C repair system YP_001852728.1 involved in transcriptional mechanism YP_001852729.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001852730.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001852733.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001852734.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001852737.1 activates fatty acids by binding to coenzyme A YP_001852738.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis YP_001852739.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001852740.1 thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulates the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis YP_001852741.1 DNAse involved in proteins export. this sec- independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity) YP_001852742.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001852743.1 function unknown but may be involved in RNA methylation YP_001852744.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852745.1 involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine] YP_001852747.1 function unknown, probably involved in cellular metabolism YP_001852748.1 the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released YP_001852749.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine YP_001852753.1 catalyzes the degradation of arginine to citruline and ammonia YP_001852758.1 thought to cause methylation YP_001852763.1 function unknown, possibly involved in cell envelope biogenesis, outer membrane YP_001852764.1 function unknown, possibly involved in lipopolysaccharide synthesis YP_001852765.1 function unknown, possible membrane protein involved in the export of O-antigen and teichoic acid YP_001852766.1 probably involved in cell wall synthesis YP_001852767.1 function unknown, contains RfaG, glycosyltransferase domain. may be involved in cell envelope biogenesis, outer membrane YP_001852773.1 function unknown; hydrolytic enzyme probably involved in cellular metabolism YP_001852775.1 function unknown; probably involved in cellular metabolism YP_001852777.1 function unknown, possibly involved in cell envelope biogenesis, outer membrane YP_001852780.1 this enzyme acetylates the N-terminal alanine of ribosomal protein S5 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine] YP_001852781.1 involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes YP_001852782.1 may play a role in stationary phase survival [catalytic activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose] YP_001852786.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001852787.1 thought to be involved in molybdopterin biosynthesis. catalyzes the dehydratation of 4A- hydroxytetrahydropterins [catalytic activity: (6R)-6-(L- erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro -4 A- hydroxypterin = (6R)-6-(L-erythro-1,2- dihydroxypropyl)- 7,8-dihydro-6H-pterin + H(2)O.] YP_001852788.1 function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues) YP_001852789.1 sensor part of a two-component regulatory system (supposed MprAB system) YP_001852790.1 regulator part of a two-component regulatory system (supposed MprAB system) YP_001852791.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001852793.1 function unknown, but involved in lipid degradation YP_001852794.1 involved in fatty acid metabolism YP_001852795.1 this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein] YP_001852796.1 function unknown, but involved in lipid metabolism YP_001852797.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001852802.1 chelation, introducing a magnesium ion into specific substrate YP_001852803.1 involved in de novo purine biosynthesis YP_001852804.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001852808.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001852810.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001852811.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001852814.1 involved in nucleotide excision repair. has a 3'-5' helicase activity in presence of ATP. preferred substrate being one with both single and double stranded regions of DNA YP_001852817.1 proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity YP_001852818.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001852819.1 function unknown, possibly involved in cellular metabolism YP_001852820.1 this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents [catalytic activity: hydrolysis of DNA containing ring-opened N7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimide] YP_001852824.1 catalyzes the formation of precorrin 6x from precorrin 5 YP_001852826.1 function unknown, probably involved in cellular metabolism YP_001852828.1 function unknown; probably involved in cellular metabolism YP_001852829.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001852832.1 function unknown; probably involved in cellular metabolism, possibly in a degradation pathway YP_001852833.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity YP_001852834.1 ATP + D-fructose = ADP + D-fructose 6-phosphate YP_001852836.1 involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport YP_001852837.1 involved in signal transduction (via phosphorylation). thought to regulate phosphate transport. can phosphorylate the peptide substrate myelin basic protein (MBP) at serine and threonine residues. can be autophosphorylated on threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001852838.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport YP_001852839.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport YP_001852840.1 involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport YP_001852841.1 function unknown, possibly involved in cellular metabolism YP_001852844.1 H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane YP_001852852.1 single copy element. N-term subunit only hence element probably not functional; transposition of an insertion sequence element YP_001852853.1 single copy element; transposition of an insertion sequence YP_001852856.1 transposition of the insertion sequence ISMyma01 YP_001852857.1 transposition of the insertion sequence ISMyma01 YP_001852862.1 single copy element; transposition of an insertion sequence. possibly IS200 family YP_001852870.1 function unknown. possibly a protective antigen involved with the early control of infection YP_001852871.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001852872.1 function unknown, probably involved in cellular metabolism YP_001852880.1 metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)] YP_001852881.1 function unknown, possibly involved in cell wall biosynthesis YP_001852883.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001852884.1 this protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [catalytic activity ATP + acetyl-CoA + HCO(3)(- ) = ADP + phosphate + malonyl-CoA] YP_001852885.1 C-term truncated 20aa.; function unknown, but maybe involved in efflux system (probably sugar or drug transport) YP_001852886.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2] YP_001852887.1 involved in cysteine biosynthesis [catalytic activity : O3-acetyl-L-serine + H(2)S = L-cysteine + acetate] YP_001852888.1 involved in lipid desaturation YP_001852889.1 involved in transcriptional mechanism YP_001852890.1 proposed role in polysaccahride synthesis YP_001852891.1 transcriptional regulator part of the two-component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth YP_001852892.1 sensor part of the two-component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth YP_001852895.1 the protein behaved as a porin of low specific activity. structural protein that may protect the integrity of the bacterium YP_001852897.1 function unknown, probably involved in cellular metabolism YP_001852898.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001852899.1 function unknown, probably involved in cellular metabolism YP_001852900.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001852901.1 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle YP_001852904.1 serves as the first electron transfer protein in all the P450 systems [catalytic activity: reduced adrenodoxin + NADP+ = oxidized adrenodoxin + NADPH] YP_001852906.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_001852909.1 causes methylation YP_001852910.1 thought to be involved in transcriptional mechanism YP_001852918.1 function unknown, but involved in lipid degradation YP_001852919.1 function unknown; thought to act in response to low temperature YP_001852921.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001852922.1 involved in molybdenum cofactor biosynthesis YP_001852923.1 function unknown. may be promote the resuscitation and growth of dormant, nongrowing cell YP_001852924.1 possibly a molybdenum biosynthesis cofactor. conversion of molybdopterin precursor Z into molybdopterin requires transfer of two sulfur atoms to precursor Z (to generate the dithiolene group). this is catalyzed by the converting factor composed of a small and large subunit YP_001852925.1 involved in molybdopterin biosynthesis; involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes YP_001852926.1 involved in the biosynthesis of molybdopterin YP_001852929.1 involved in nucleotide excision repair. has helicase activity: acts by opening DNA either around the RNA transcription start site or the DNA damage YP_001852932.1 function unknown, may have reductase activity YP_001852935.1 involved in fatty acid degradation (probably in fatty acid beta-oxidation cycle) YP_001852936.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001852937.1 function unknown, probably involved in cellular metabolism YP_001852940.1 function unknown, but involvement in lipid degradation (racemization) YP_001852941.1 conserved hypothetical protein YP_001852942.1 possible indole-3-pyruvate decarboxylase; [catalytic activity: 3-(indol-3-YL) pyruvate = 2-(indol-3- YL)acetaldehyde + CO2], or possible pyruvate decarboxylase; [catalytic activity: a 2-OXO acid = an aldehyde + CO2] YP_001852943.1 conserved hypothetical protein YP_001852944.1 function unknown, but involved in lipid degradation YP_001852947.1 activates fatty acids by binding to coenzyme A YP_001852948.1 function unknown, contains a hydrolytic domain YP_001852950.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001852952.1 involved in transcriptional mechanism YP_001852953.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852955.1 function unknown role in electron transport YP_001852964.1 function unknown, but thought involved in host cell invasion YP_001852965.1 function unknown, but thought to be involved in host cell invasion YP_001852966.1 function unknown, but thought to be involved in host cell invasion YP_001852967.1 function unknown, but thought to be involved in host cell invasion YP_001852968.1 function unknown, but thought to be involved in host cell invasion YP_001852969.1 function unknown, but thought to be involved in host cell invasion YP_001852973.1 oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH] YP_001852974.1 involved in the fatty acid biosynthesis [catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH] YP_001852975.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001852976.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852977.1 function unknown, but supposed involvement in lipid degradation YP_001852978.1 function unknown, but supposed involvement in lipid degradation YP_001852980.1 function unknown; probably involved in cellular metabolism YP_001852981.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate] YP_001852985.1 could as ferredoxin subunits of nitrite reductase YP_001852988.1 involved in aerobic|anaerobic respiration [catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol] YP_001852989.1 required for electron transfer YP_001852990.1 function unknown, supposed involvement in lipid metabolism. may have specificity for branched-chain acyl CoAs YP_001852991.1 ensuring efficient processing by acyl-synthase machinery E.G. PKS YP_001852992.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852993.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001852995.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001852996.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001852998.1 involved in transcriptional mechanism YP_001852999.1 function unknown, but involved in lipid degradation [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA] YP_001853000.1 function unknown, but involved in lipid metabolism YP_001853001.1 function unknown role in cellular metabolism YP_001853003.1 function unknown; involved in cellular metabolism YP_001853005.1 imidazolonepropionase is an amidohydrolase YP_001853007.1 function unknown, but involved in lipid degradation YP_001853008.1 function unknown, but involved in lipid degradation YP_001853009.1 function unknown, possibly involved in transport of sulfate across the membrane YP_001853010.1 function unknown, but supposed involvement in lipid degradation YP_001853011.1 could be involved in transcriptional mechanism YP_001853012.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853013.1 function unknown; possibly involved in cellular metabolism YP_001853014.1 function unknown, possibly involved in cellular metabolism YP_001853015.1 function unknown, probably involved in cellular metabolism YP_001853017.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001853018.1 function unknown, hydrolyses peptides YP_001853019.1 hydrolysis of peptide bonds YP_001853021.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853022.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001853023.1 function unknown, maybe a transcriptional regulator YP_001853025.1 function unknown; domain homology to nucleoside- diphosphate-sugar epimerases YP_001853026.1 thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane YP_001853027.1 thought to be involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L- cysteine + acetate] YP_001853029.1 probable oxidase, showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins YP_001853030.1 function unknown, predicted hydrolase or acyltransferase domain YP_001853031.1 putative cyclase YP_001853032.1 catalyzes the formation of 5-alpha-androstane-3,17-dione from androsterone; Acts on other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. YP_001853034.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione YP_001853035.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family YP_001853036.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate YP_001853037.1 involved in the degradation of biphenyl YP_001853038.1 involved in transcriptional mechanism YP_001853040.1 possible sensor part of a two-component regulatory system YP_001853042.1 possible sensor part of a two-component regulatory system YP_001853046.1 transport system kinase - possibly arginine YP_001853047.1 function unknown but may be involved in fatty acid oxidation (beta oxidation) YP_001853048.1 specifically catalyzes the removal of N-terminal proline residues from peptides. thought to release the N- terminal proline from the dipeptides, pro-pro, pro-gln, pro-trp and pro-tyr; also from amides (pro-beta na) and oligopeptides, pro-leu-glynH2, pro-leu-gly and pro-phe-gly- lys. higher activity toward small peptides (up to three residues), but very low activity for longer peptides [catalytic activity: release of a N-terminal proline from a peptide] YP_001853049.1 lipid metabolism YP_001853050.1 involved in lipid metabolism YP_001853051.1 involved in lipid metabolism YP_001853053.1 similar to ferredoxin reductase electron transfer proteins YP_001853056.1 involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity : (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA.] YP_001853057.1 catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [catalytic activity : (R)-2-methyl-3-oxopropanoyl-CoA = succinyl- CoA.]. the enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. the enzyme induces the formation of an adenosyl radical from the cofactor. this radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA YP_001853058.1 possible methylase YP_001853061.1 contains a N-term cellobiohydrolase a (1,4-beta- cellobiosidase a) domain and a C-term cellulose-binding domain (CBD) domain. the CBD is found either at the N-term or at the C-terminal extremity of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases YP_001853062.1 transmembrane protein YP_001853063.1 function unknown; possible role in carotenoid pigment biosynthesis given linkage to CrtI and CrtB YP_001853064.1 converts farensyl pyrophosphate to geranylgeranyl pyrophosphate, the latter being the substrate for CrtB in the production of phytoene during carotenoid synthesis YP_001853065.1 part of carotenoid biosynthesis cluster YP_001853066.1 part of carotenoid biosynthesis cluster - photochromogenesis YP_001853067.1 involved in carotenoid biosynthesis YP_001853068.1 involved in carotenoid biosynthesis YP_001853069.1 function unknown. thought to be involved in fatty acid transport YP_001853070.1 involved in transcriptional mechanism YP_001853071.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_001853074.1 involved in L-asparagine transport YP_001853076.1 function unknown, predicted ATPase domain YP_001853077.1 probable dehydrogenase YP_001853079.1 contains amidohydrolase domain YP_001853080.1 function unknown; contains amidohydrolase domain YP_001853082.1 possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures) YP_001853083.1 function unknown, possibly involved in ATP- dependent RNA unwinding, enzymes of this class are needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation YP_001853085.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001853086.1 contains a nucleotidyltransferase domain YP_001853092.1 involved in transcriptional mechanism YP_001853093.1 cytochrome P450s are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853094.1 possibly involved in a transcriptional mechanism YP_001853096.1 thought to be involved in fatty acid transport YP_001853097.1 function unknown YP_001853099.1 involved in transcriptional mechanism YP_001853100.1 involved in transcriptional mechanism YP_001853101.1 may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair YP_001853102.1 involved in unknown transcriptional regulatory network YP_001853104.1 transposition of the insertion sequence ISMyma01 YP_001853105.1 transposition of the insertion sequence ISMyma01 YP_001853107.1 part of a prophage not present in M. ulcerans. however a highly related integrase is present in M. ulcerans YP_001853109.1 function unknown, may be involved in polyketide biosynthesis [secondary metabolites biosynthesis, transport, and catabolism] YP_001853110.1 domain homology to CumB, cytosine/adenosine deaminases YP_001853115.1 involved in mycolic acid biosynthesis YP_001853116.1 domain homology - tRNA-dihydrouridine synthase [translation, ribosomal structure and biogenesis] YP_001853117.1 domain conservation - LytR, transcriptional regulator YP_001853118.1 involved in transcriptional regulation of active transport of inorganic phosphate across the membrane YP_001853119.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001853120.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport YP_001853121.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport YP_001853122.1 involved in phosphate transport YP_001853123.1 involved in the fourth step of mycothiol biosynthesis YP_001853124.1 involved in transcriptional mechanism YP_001853127.1 may be a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate] YP_001853129.1 no H37Rv ortholog - very small, doubtful ORF YP_001853130.1 N-terminal truncated in relation to orthologs YP_001853131.1 contains a RyR domain. This domain is called RyR for Ryanodine receptor YP_001853132.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_001853135.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)] YP_001853137.1 contains predicted aminomethyltransferase domain, related to GcvT - involved in the catabolism of glycine YP_001853139.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001853140.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001853144.1 thought to be involved in exopolysaccharide and/or lipopolysaccharide biosynthetic pathway [catalytic activity: UDP-glucose = UDP-galactose] YP_001853145.1 contains phosphohydrolase domain YP_001853146.1 contains CAAX amino terminal protease domain. members of this family are probably proteases; the family contains CAAX prenyl protease. the proteins contain a highly conserved Glu-Glu motif at the amino End of the alignment. the alignment also contains two histidine residues that may be involved in zinc binding YP_001853147.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001853148.1 domain similarity with acetyltransferases YP_001853150.1 catalyzes the removal of amino acids from the N termini of peptides YP_001853151.1 contains Dyp-type peroxidase domain. this family of dye-decolourising peroxidases lack a typical heme-binding region YP_001853152.1 function unknown, high domain homology to Linocin_M18, Linocin_M18 bacteriocin protein. the Linocin_M18 region is found mostly in eubacteria, though homologous sequences have been identified in archaea YP_001853153.1 contains pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component domain YP_001853154.1 contains mannose-6-phosphate isomerase [carbohydrate transport and metabolism] YP_001853156.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001853157.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway YP_001853161.1 function unknown; belongs to the LysR family of transcriptional regulators YP_001853164.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane YP_001853165.1 TetR-family YP_001853167.1 cleaves peptide bonds on the C-terminal side of LysYL and argininyl residues [catalytic activity: hydrolysis of arg-|-xaa and lys-|-xaa bonds in oligopeptides, even when P1' residue is proline] YP_001853168.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001853171.1 interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH] YP_001853172.1 possibly involed in transcription regulation; DNA- binding YP_001853174.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853175.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001853177.1 contains transcriptional regulatory domain YP_001853178.1 function unknown, contains esterase domain YP_001853179.1 besides the cephalosporin acylase I activity which converts GL-7ACA into 7-Aca; this enzyme displays some gamma glutamyltranspeptidase activity: Ggt plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. [catalytic activity 1: 7-beta-(4-carboxybutanamido)-cephalosporanic acid + H2O = 7-aminocephalosporanic acid + glutaric acid] [catalytic activity 2: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid] YP_001853180.1 involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD) YP_001853181.1 domain: UspA, universal stress protein UspA and related nucleotide-binding proteins [signal transduction mechanisms] YP_001853182.1 involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein] YP_001853183.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001853184.1 involved in aromatic hydrocarbons catabolism. thought to be involved in the catabolism of protocatechuate to succinate-and acetyl-CoA in the beta- ketoadipate pathway (at the third step) [catalytic activity: 2-carboxy-5-OXO-2,5-dihydrofuran-2-acetate = 5- OXO-4,5-dihydrofuran-2-acetate + CO(2)] YP_001853187.1 oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH] YP_001853189.1 cytochrome P450s are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853190.1 function unknown, domain homology to short-chain dehydrogenase/reductase family YP_001853191.1 involved in sterol biosynthesis. its biological substrate is not known. catalyzes C14-demethylation of lanosterol, 24,25-DIHYDROLANOSTEROL and obtusifoliol which is critical for ergosterol biosynthesis. it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3- beta-ol YP_001853192.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably involved in electron transport for cytochrome P- 450 system YP_001853194.1 thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH] YP_001853195.1 function unknown, domain homology suggests possible NADH:flavin oxidoreductase YP_001853196.1 contains nuclear transport factor 2 (NTF2) domain YP_001853199.1 hit family protein: diadenosine tetraphosphate (Ap4A) hydrolase and other hit family hydrolases [nucleotide transport and metabolism / carbohydrate transport and metabolism / general function prediction only] YP_001853200.1 sensor part of a two-component regulatory system. this protein is thought to be a sensor kinase for the phosphate regulon. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited YP_001853201.1 involved in transcriptional mechanism. part of the two-component regulatory system PhoP/PhoQ. this protein is thought to be a positive regulator for the phosphate regulon, required for intracellular growth. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited YP_001853203.1 domain: UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [coenzyme metabolism / energy production and conversion] YP_001853205.1 domain: xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit a [nucleotide transport and metabolism] YP_001853206.1 domain homology: transthyretin, transthyretin precursor (formerly prealbumin). transthyretin is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. mutations in the human transthyretin are associated with several genetic disorders YP_001853208.1 permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices YP_001853209.1 thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate] YP_001853210.1 domain: regulator of polyketide synthase expression YP_001853211.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001853213.1 hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)] YP_001853215.1 function unknown; facilitates transport of small solutes in or out of the cell YP_001853219.1 supposed involved in detoxification reactions YP_001853221.1 possibly involved in the uptake of malate and other dicarboxylates by a proton symport mechanism. in E. coli, this protein has been implicated in resistance to tellurite YP_001853225.1 function unknown but contains a cell envelope- related transcriptional attenuator domain. CpsA is a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane- bound proteins. may play a role in regulation of transcription YP_001853226.1 function unknown, probably involved in cellular metabolism YP_001853227.1 function unknown, supposed to be involved in cellular metabolism YP_001853228.1 probable role in the biosynthesis of the product from U/S PKS gene, carrying its acyl intermediates YP_001853229.1 activates fatty acids by binding to coenzyme A YP_001853230.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2] YP_001853231.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001853232.1 function unknown but domain identity suggests permease component of an uncharacterized ABC-type transport system YP_001853233.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for energy coupling to the transport system. this is one of the proteins required for binding-protein-mediated phosphate transport. have ATP-binding ability and ATPase activity YP_001853234.1 function unknown. belongs to the predicted drug exporters of the rnd superfamily YP_001853235.1 members of the PadR-like family are transcriptional regulators that appear to be related to the pfam01047 family. this family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism YP_001853237.1 involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate] YP_001853241.1 function unknown, but thought involved in host cell invasion YP_001853242.1 function unknown, but thought to be involved in host cell invasion YP_001853243.1 function unknown, but thought to be involved in host cell invasion YP_001853244.1 function unknown, but thought to be involved in host cell invasion YP_001853245.1 function unknown, but thought to be involved in host cell invasion YP_001853246.1 function unknown, but thought to be involved in host cell invasion YP_001853249.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001853250.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_001853251.1 function unknown, but involved in lipid degradation YP_001853252.1 function unknown, but involved in lipid degradation YP_001853253.1 activates fatty acids by binding to coenzyme A YP_001853255.1 function unknown but contains beta- lactamase/transpeptidase-like superfamily domain YP_001853256.1 thiamine-pyrophosphate requiring enzyme YP_001853257.1 function unknown. these proteins are related to the metal-dependent hydrolase superfamily YP_001853260.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence YP_001853261.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001853262.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853264.1 function unknown, probably involved in cellular metabolism YP_001853265.1 function unknown, contains a C-term predicted nucleic-acid-binding domain YP_001853266.1 function unknown, probably involved in lipid metabolism YP_001853267.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001853268.1 function unknown, probably involved in cellular metabolism YP_001853269.1 function unknown, this class of proteins is involved in enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon YP_001853272.1 function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages YP_001853273.1 function unknown, contains carbonic anhydrases/acetyltransferase superfamily domain YP_001853274.1 function unknown, probably involved in cellular metabolism YP_001853276.1 function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain YP_001853277.1 function unknown, probably involved in cellular metabolism YP_001853279.1 function unknown, this enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis YP_001853280.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_001853281.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_001853282.1 function unknown; probably involved in cellular metabolism YP_001853283.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione YP_001853284.1 function unknown, probably involved in cellular metabolism YP_001853285.1 function unknown, contains restriction endonuclease- like superfamily domain YP_001853286.1 function unknown, supposed involvement in lipid metabolism YP_001853287.1 function unknown, potential role in lipid metabolism. contains thioesterase/thiol ester dehydrase- isomerase superfamily domain YP_001853288.1 function unknown, contains a predicted C-term nucleic-acid-binding protein YP_001853289.1 function unknown, but involved in lipid degradation YP_001853290.1 function unknown, but involved in lipid degradation YP_001853291.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853292.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001853294.1 function unknown; contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential YP_001853295.1 function unknown, supposed involvement in cellular metabolism YP_001853296.1 function unknown, supposed involvement in cellular metabolism YP_001853298.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001853299.1 function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another YP_001853300.1 function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another YP_001853301.1 function unknown, members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor YP_001853302.1 function unknown, c-terminus probably involved in electron transfer in one or several metabolic reactions YP_001853304.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001853305.1 involved in transcriptional mechanism YP_001853307.1 function unknown, probably involved in cellular metabolism YP_001853308.1 function unknown, but involved in lipid degradation YP_001853309.1 activates fatty acids by binding to coenzyme A YP_001853310.1 function unknown, but involved in lipid degradation YP_001853311.1 function unknown, but involved in lipid degradation YP_001853312.1 function unknown, but involved in lipid degradation YP_001853313.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001853314.1 could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [catalytic activity: acetyl-CoA + arylamine = CoA + N- acetylarylamine] YP_001853315.1 function unknown YP_001853316.1 function unknown, possibly involved in thiol:disulfide interchange. contains PS00013 prokaryotic membrane lipoprotein lipid attachment site, N-term signal pepitde sequence and PS00194 thioredoxin family active site YP_001853318.1 function unknown, but domain identity suggests this protein may have metalloendopeptidase activity YP_001853319.1 involved in transcriptional mechanism YP_001853321.1 function unknown, probably involved in cellular metabolism YP_001853322.1 involved in the degradation of biphenyl [catalytic activity: biphenyl-2,3-diol + O(2) = 2-hydroxy-6-OXO-6- phenylhexa-2,4-dienoate + H(2)O] YP_001853323.1 involved in the degradation of biphenyl YP_001853324.1 function unknown, probably involved in cellular metabolism YP_001853325.1 may play a role in protection from oxidative (nitric oxide) and nitrosative stress. may also be involved in anaerobic metabolism. could have nitric oxide dioxygenase activity YP_001853327.1 function unknown, but involved in lipid degradation YP_001853328.1 involved in transcriptional mechanism YP_001853329.1 involved in transcriptional mechanism YP_001853330.1 function unknown, domain identity suggests periplasmic solute binding protein, containing an ATP- binding cassette transport system YP_001853331.1 function unknown, part of a binding-protein- dependent ABC transport system YP_001853332.1 part of an ABC transport system YP_001853335.1 function unknown, the lam locus of aspergillus nidulans consists of two divergently transcribed genes, lama and LamB, involved in the utilization of lactams such as 2-pyrrolidinone. both genes are under the control of the positive regulatory gene AmdR and are subject to carbon and nitrogen metabolite repression. the exact molecular function of the proteins in this family is unknown YP_001853337.1 thought to be involved in transport of arsenic across the membrane (export): arsenic resistance by an export mechanism. form the channel of an arsenite pump responsible for the translocation of the substrate across the membrane YP_001853338.1 function unknown role in tRNA and rRNA base modification by methylation YP_001853339.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001853340.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001853341.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001853342.1 function unknown role in regulation YP_001853344.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001853345.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair YP_001853347.1 catalyzes the reversible hydratation of carbon dioxide [catalytic activity: H(2)CO(3) = CO(2) + H(2)O] YP_001853348.1 involved in base excision repair. removes adenine mispaired with 8-OXOG. may repair a.G and a.C mismatches by adenine excision YP_001853349.1 function unknown, probably involved in cellular metabolism YP_001853350.1 TB11.2 YP_001853352.1 transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates YP_001853353.1 thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane YP_001853354.1 involved in the biosynthesis of membrane ether- linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [catalytic activity1: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate] [catalytic activity2: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans- farnesyl diphosphate] [catalytic activity3: trans-trans- farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate] YP_001853355.1 may be involved in the catalysis of both the synthesis and the degradation of fructose-2,6- bisphosphate. beta-D-fructose 2,6-bisphosphate + H(2)O <=> D-fructose 6-phosphate + phosphate YP_001853359.1 hydrolyses proteins in presence of ATP. may interact with a ClpP-like protease involved in degradation of denatured proteins YP_001853360.1 dominant T-cell antigen and may stimulate lymphocyte proliferation YP_001853361.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001853362.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_001853363.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001853364.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001853365.1 function unknown contains NAD(P)-binding Rossmann- fold superfamily domains YP_001853368.1 involved in dihydrofolate biosynthesis (at the first step) [catalytic activity: ATP + 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8- dihydro-4-hydroxy-6-(diphosphooxymethyl)pteri di ne] YP_001853369.1 involved in folate biosynthesis. catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8- dihydropterin (by similarity) [catalytic activity: 2-amino- 4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7, 8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine + glycolaldehyde] YP_001853370.1 involved in dihydrofolate biosynthesis (at the second step). catalyzes the formation of the immediate precursor of folic acid. it is implicated in resistance to sulfonamide [catalytic activity: 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine diphosphate + 4- aminobenzoate = pyrophosphate + dihydropteroate] YP_001853371.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001853372.1 thought to act as an ATP-dependent zinc metallopeptidase, with ATPase and proteolytic activities. probably has a regulatory role in stress response and specific proteins secretion for adaptation to host environment YP_001853373.1 biotransformation enzyme that catalyzes the hydrolysis of epoxides (alkene oxides, oxiranes) and Arene oxides to less reactive and more water soluble dihydrodiols by the trans addition of water. thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol] YP_001853375.1 function unknown; probably involved in cellular metabolism YP_001853383.1 involved in purine salvage [catalytic activity: imp + pyrophosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (guanine can replace hypoxanthine to produce GMP)] YP_001853384.1 predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_001853386.1 involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine] YP_001853387.1 involved in the function of cellular bioenergetics [catalytic activity: pyrophosphate + H(2)O = 2 orthophosphate] YP_001853390.1 function unknown, the domain detected in this CDS is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids YP_001853392.1 involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose] YP_001853395.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001853396.1 C-term contains an adenylyl/guanylyl cyclase domain. may catalyze the formation of cyclic AMP/GMP from ATP/GTP YP_001853397.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001853399.1 possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures) YP_001853400.1 function unknown. helicases are involved in unwinding nucleic acids. the DeaD box helicases are involved in various aspects of RNA metabolism YP_001853406.1 function unknown, contains domain identity to Flp pilus assembly protein TadB YP_001853407.1 function unknown, contains domain identity with Flp pilus assembly protein, ATPase CpaF YP_001853408.1 function unknown, has a P-loop containing nucleoside triphosphate hydrolase superfamily domain YP_001853409.1 phosphoserine + H(2)O <=> serine + phosphate YP_001853412.1 involved in active transport of dipeptides across the membrane (import). responsible for energy coupling to the transport system YP_001853413.1 involved in active transport of dipeptide across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001853414.1 involved in active transport of dipeptide across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001853415.1 thought to be involved in active transport of dipeptide across the membrane (import) YP_001853416.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001853417.1 function unknown, domain identity suggests peptidase, trypsin-like serine or cysteine protease. contains peptidase S1B, active site YP_001853419.1 thought to be involved in detoxification reactions following oxidative damage to lipids. biotransformation enzyme that catalyzes the hydrolysis of epoxides: aromatic hydrocarbons catabolism [catalytic activity: an epoxide + H(2)O = a glycol] YP_001853420.1 function unknown, hydrolyses of peptides and/or proteins (possibly cleaved preferentially after serine residue). contains peptidase S1B, active site YP_001853421.1 function unknown: contains a NUDIX domain YP_001853422.1 function unknown, contains a N-term thioredoxin domain. may serve as a general protein disulphide oxidoreductase YP_001853423.1 has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. incises damaged DNA at cytosines, thymines and guanines. acts on a damaged strand (oxidized pyrimidines), 5' from the damaged site [catalytic activity: endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate] YP_001853425.1 involved in transcriptional mechanism YP_001853426.1 function unknown, probably involved in cellular metabolism YP_001853427.1 function unknown, this endoribonuclease domain is active on single-stranded mRNA and inhibits protein synthesis by cleavage of mRNA YP_001853429.1 function unknown, may catalyze the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)] YP_001853430.1 anion-transporting ATPase; supposed catalyzes the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)] YP_001853431.1 involved in a transcriptional mechanism YP_001853432.1 involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) YP_001853433.1 function unknown, contains metallophosphoesterase domain YP_001853434.1 function unknown, probably involved in cellular metabolism. reaction catalysed: O(3)-acetyl-L-serine + H(2)S <=> L-cysteine + acetate YP_001853436.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853439.1 function unknown; contains pas domain. this is usually associated with the input domain of a histidine kinase, or a sensor protein that regulates a histidine kinase YP_001853441.1 function unknown; potential role in regulation of transcription YP_001853442.1 function unknown; potential role in regulation of transcription YP_001853443.1 function unknown; contains an anti-anti-sigma regulatory factor domain. may have a role in a signal transduction mechanism YP_001853444.1 function unknown; contains a kinase domain. possible role in signal transduction mechanism YP_001853445.1 function unknown; contains a sigma factor PP2C-like phosphatase domain. probably part of a signal transduction locus YP_001853447.1 function unknown. thought to be regulated by LexA YP_001853448.1 function unknown; domain homology suggests a role as an intracellular protease/amidase YP_001853449.1 involved in thiamine biosynthesis [catalytic activity: ATP + thiamine phosphate = ADP + thiamine diphosphate] YP_001853450.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001853451.1 this protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis YP_001853452.1 function unknown; extensive overlap with D/S CDS on opposite strand YP_001853454.1 function unknown; potential role in anaerobic electron transport chain. contains formate dehydrogenase/DMSO reductase superfamily domain YP_001853455.1 function unknown; potential role in anaerobic electron transport chain YP_001853457.1 NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway YP_001853458.1 function unknown, contains GatB/Yqey domain. this domain is found at the C terminus of GatB which transamidates glu-tRNA to Gln-tRNA YP_001853462.1 involved in transcriptional mechanism; regulates methanol dehydrogenase YP_001853463.1 function unknown, contains N-term signal peptide YP_001853465.1 function unknown, contains RDD domain RDD family. the molecular function of this region is unknown. however this region may be involved in transport of an as yet unknown set of ligands YP_001853468.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001853470.1 function unknown; contains thiopurine S- methyltransferase domain. this is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds YP_001853471.1 probable role in the metabolism of proteins containing the rare amino acid selenocysteine YP_001853473.1 function unknown, contains N-terminal nucleophile aminohydrolase superfamily domain YP_001853475.1 involved in glutathione biosynthesis (at the first step) [catalytic activity: ATP + L-glutamate + L-cysteine = ADP + orthophosphate + gamma-L-glutamyl-L-cysteine] YP_001853477.1 protects against oxidative stress. converts hydrogen peroxide to water and molecular oxygen YP_001853478.1 function unknown, rich in short repeat motifs YP_001853479.1 function unknown, rich in short repeat motifs YP_001853481.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001853482.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001853483.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane YP_001853485.1 involved in leucine biosynthesis (at the first step). catalyzes condensation of acetyl-CoA and 2- oxoisovalerate to form 2-isopropylmalate synthase [catalytic activity: 3-carboxy-3-hydroxy-4- methylpentanoate + CoA = acetyl-CoA + 3-methyl-2- oxobutanoate + H(2)O] YP_001853486.1 involved in transcriptional mechanism YP_001853487.1 function unknown, contains multidrug efflux transporter AcrB transmembrane superfamily domain YP_001853488.1 3'-5' exonuclease of DNA polymerase III YP_001853489.1 possible role in cell wall peptidoglycan biogenesis. contains Mur ligase family catalytic domain. possible UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase, required for the formation of the UDP- MurNAc-linked pentapeptide by addition of the D-Ala-D-Ala subgroup YP_001853490.1 involved in cobalamin biosynthesis. catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic a,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (by similarity) YP_001853491.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001853493.1 hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides YP_001853494.1 function unknown, contains bet v1-like superfamily domain YP_001853496.1 cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase catalyses the reaction: S-adenosyl-L- methionine + phospholipid olefinic fatty acid -> S- adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. CFA synthase is closely related to methyltransferases YP_001853500.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001853503.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O] YP_001853511.1 hydrolysis of cutin (a polyester that forms the structure of plant cuticle) YP_001853512.1 function unknown, probably involved in cellular metabolism YP_001853514.1 involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase YP_001853517.1 involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase YP_001853525.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth YP_001853527.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics YP_001853531.1 function unknown, involved in cellular metabolism YP_001853534.1 function unknown, but involved in lipid degradation YP_001853535.1 involved in transcriptional mechanism YP_001853538.1 function unknown role in oxidoreduction YP_001853541.1 involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH] YP_001853542.1 involved in lipid metabolism YP_001853543.1 aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates) YP_001853547.1 function unknown, supposed involvement in cellular metabolism YP_001853548.1 function unknown, probably involved in cellular metabolism YP_001853554.1 function unknown, probably involved in deamination of specific substrate YP_001853556.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_001853558.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001853559.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane YP_001853560.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for energy coupling to the transport system YP_001853561.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) YP_001853563.1 function unknown, but possibly involvement in lipid degradation YP_001853569.1 function unknown, possibly involved in cellular metabolism YP_001853570.1 function unknown, but involved in lipid degradation YP_001853572.1 possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone] YP_001853573.1 function unknown, probably involved in cellular metabolism YP_001853575.1 sensor part of a two-component regulatory system YP_001853576.1 sensor part of a two-component regulatory system YP_001853582.1 function unknown, may play a role in secondary metabolites biosynthesis, transport, and catabolism YP_001853585.1 involved in histidine biosynthetic pathway (at the eighth step) [catalytic activity: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + glutamate] YP_001853588.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001853589.1 function unknown, lipolytic enzyme probably involved in cellular metabolism YP_001853591.1 function unknown, probably involved in cellular metabolism YP_001853592.1 function unknown, probably involved in cellular metabolism YP_001853595.1 may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbD. responsible for energy coupling to the transport system YP_001853596.1 possibly involved in rhamnose biosynthesis YP_001853597.1 may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbE. responsible for the translocation of the substrate across the membrane YP_001853602.1 involved in transcriptional mechanism YP_001853605.1 involved in dTDP-L-rhamnose biosynthesis [catalytic activity: dTDP-glucose = DTDP-4-dehydro-6-deoxy-D-glucose + H(2)O] YP_001853606.1 function unknown; domain homology to metallopeptidases YP_001853609.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_001853611.1 function unknown, probably involved in cellular metabolism YP_001853612.1 function unknown, supposed involved in cellular metabolism YP_001853614.1 involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside] YP_001853615.1 involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside] YP_001853616.1 involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside] YP_001853620.1 function unknown, but involved in lipid degradation YP_001853622.1 key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.] YP_001853623.1 the enzyme responsible for the final condensation step in mycolic acid biosynthesis, bringing the short and long (mero) chains together YP_001853624.1 activates fatty acids by binding to coenzyme A YP_001853626.1 involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity YP_001853627.1 involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity YP_001853629.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate YP_001853631.1 converts UDP-galactofuranose in cell wall galactan polymerization. has UDP-GalF:beta-D-(1->5) and UDP- GalF:beta-D-(1->6) galactofuranosyltransferase activities YP_001853632.1 involved in lipopolysaccharide biosynthesis, in the conversion of UDP-galactopyranose into UDP-galactofuranose through a 2-keto intermediate [catalytic activity: UDP-D- galactopyranose = UDP-D-galacto-1,4-furanose] YP_001853633.1 surface-exposed protein required for multiplication and intracellular growth. seems to play a role in virulence YP_001853636.1 function unknown, probably involved in cellular metabolism YP_001853637.1 function unknown, probably involved in cellular metabolism YP_001853638.1 function unknown, probably involved in cellular metabolism YP_001853639.1 function unknown, probably involved in cellular metabolism [catalytic activity: ATP + substrate = ADP + substrate 3'-phosphate] YP_001853642.1 function unknown, probably involved in cellular metabolism YP_001853643.1 involved in transcriptional mechanism YP_001853645.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001853648.1 thought to be involved in glycolisis and perhaps glycogen metabolism [catalytic activity: 3- phosphoglycerate = 2-phosphoglycerate] YP_001853649.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001853651.1 supposed involved in transcriptional mechanism YP_001853652.1 involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited YP_001853653.1 glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate] YP_001853656.1 destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 peroxide radical + 2 H(+) = O(2) + H(2)O(2)] YP_001853663.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001853664.1 activates the pro-drug ethionamide (eth); induced eth sensitivity when overexpressed in mycobacterium tuberculosis YP_001853665.1 regulates negatively the production of EthA. induced eth resistance when overexpressed in mycobacterium tuberculosis YP_001853666.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001853674.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001853675.1 probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH] YP_001853698.1 function unknown; contains SpoJ ATPase domain YP_001853700.1 function unknown; potential regulatory role. contains a FHA domain. the FHA (forkhead-associated) domain is a phosphopeptide binding motif YP_001853705.1 function unknown; contains predicted ATPase domain YP_001853711.1 function unknown; a component of a novel secretion apparatus. (10 kDa culture filtrate antigen cfp10) YP_001853712.1 function unknown; probably a component of a novel secretion mechanism. forms a heterodimer with EsxB YP_001853713.1 function unknown YP_001853719.1 Required for intracellular persistence YP_001853721.1 thought to have proteolytic activity YP_001853725.1 related to a family of actin-ADP-ribosylating toxins from bacillus and clostridia hence may play a role in virulence or protection against predation YP_001853732.1 involved in transcription mechanism [catalytic activity: N ATP + (nucleotide)(M) = N diphosphate + (nucleotide)(M+N)] YP_001853736.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase YP_001853738.1 enzyme that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. seems regulated by SigH. [catalytic activity: NADPH + oxidized thioredoxin = NADP(+) + reduced thioredoxin] YP_001853739.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions. forms together with thioredoxin reductase and NADPH a redox active system which donates electrons to a wide variety of different metabolic process (by similarity). seems regulated by SigH YP_001853740.1 function unknown, probably involved in cellular metabolism YP_001853742.1 involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication. binds to the DNA origin of replication (by similarity) YP_001853743.1 involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication (by similarity) YP_001853744.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001853745.1 function unknown, domain identity suggests it is a JAG RNA-binding protein YP_001853746.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001853748.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001853749.1 in Escherichia coli transcription of this gene is enhanced by polyamines