-- dump date   	20140619_153205
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1198627000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1198627000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627000003	Walker A motif; other site
1198627000004	ATP binding site [chemical binding]; other site
1198627000005	Walker B motif; other site
1198627000006	arginine finger; other site
1198627000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1198627000008	DnaA box-binding interface [nucleotide binding]; other site
1198627000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
1198627000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1198627000011	putative DNA binding surface [nucleotide binding]; other site
1198627000012	dimer interface [polypeptide binding]; other site
1198627000013	beta-clamp/clamp loader binding surface; other site
1198627000014	beta-clamp/translesion DNA polymerase binding surface; other site
1198627000015	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1198627000016	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
1198627000017	recombination protein F; Reviewed; Region: recF; PRK00064
1198627000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1198627000019	Walker A/P-loop; other site
1198627000020	ATP binding site [chemical binding]; other site
1198627000021	Q-loop/lid; other site
1198627000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627000023	ABC transporter signature motif; other site
1198627000024	Walker B; other site
1198627000025	D-loop; other site
1198627000026	H-loop/switch region; other site
1198627000027	hypothetical protein; Provisional; Region: PRK03195
1198627000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1198627000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627000030	ATP binding site [chemical binding]; other site
1198627000031	Mg2+ binding site [ion binding]; other site
1198627000032	G-X-G motif; other site
1198627000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1198627000034	anchoring element; other site
1198627000035	dimer interface [polypeptide binding]; other site
1198627000036	ATP binding site [chemical binding]; other site
1198627000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1198627000038	active site
1198627000039	putative metal-binding site [ion binding]; other site
1198627000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1198627000041	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1198627000042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627000043	S-adenosylmethionine binding site [chemical binding]; other site
1198627000044	DNA gyrase subunit A; Validated; Region: PRK05560
1198627000045	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1198627000046	CAP-like domain; other site
1198627000047	active site
1198627000048	primary dimer interface [polypeptide binding]; other site
1198627000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1198627000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1198627000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1198627000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1198627000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1198627000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1198627000055	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1198627000056	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1198627000057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627000058	putative substrate translocation pore; other site
1198627000059	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1198627000060	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627000061	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1198627000062	dimerization interface [polypeptide binding]; other site
1198627000063	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1198627000064	active site
1198627000065	Rhomboid family; Region: Rhomboid; pfam01694
1198627000066	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627000067	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627000068	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1198627000069	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1198627000070	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1198627000071	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1198627000072	glutamine binding [chemical binding]; other site
1198627000073	catalytic triad [active]
1198627000074	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1198627000075	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1198627000076	active site
1198627000077	ATP binding site [chemical binding]; other site
1198627000078	substrate binding site [chemical binding]; other site
1198627000079	activation loop (A-loop); other site
1198627000080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1198627000081	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1198627000082	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1198627000083	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1198627000084	PASTA domain; Region: PASTA; pfam03793
1198627000085	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1198627000086	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1198627000087	active site
1198627000088	ATP binding site [chemical binding]; other site
1198627000089	substrate binding site [chemical binding]; other site
1198627000090	activation loop (A-loop); other site
1198627000091	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1198627000092	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1198627000093	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1198627000094	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1198627000095	active site
1198627000096	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1198627000097	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1198627000098	PPE family; Region: PPE; pfam00823
1198627000099	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1198627000100	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1198627000101	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1198627000102	nucleoside/Zn binding site; other site
1198627000103	dimer interface [polypeptide binding]; other site
1198627000104	catalytic motif [active]
1198627000105	cyanate hydratase; Validated; Region: PRK02866
1198627000106	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
1198627000107	oligomer interface [polypeptide binding]; other site
1198627000108	active site
1198627000109	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1198627000110	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627000111	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
1198627000112	dimerization interface [polypeptide binding]; other site
1198627000113	short chain dehydrogenase; Provisional; Region: PRK07041
1198627000114	classical (c) SDRs; Region: SDR_c; cd05233
1198627000115	NAD(P) binding site [chemical binding]; other site
1198627000116	active site
1198627000117	AAA domain; Region: AAA_31; pfam13614
1198627000118	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1198627000119	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1198627000120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627000121	active site
1198627000122	phosphorylation site [posttranslational modification]
1198627000123	intermolecular recognition site; other site
1198627000124	dimerization interface [polypeptide binding]; other site
1198627000125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1198627000126	DNA binding residues [nucleotide binding]
1198627000127	dimerization interface [polypeptide binding]; other site
1198627000128	mycothione reductase; Reviewed; Region: PRK07846
1198627000129	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627000130	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627000131	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1198627000132	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1198627000133	Beta-lactamase; Region: Beta-lactamase; pfam00144
1198627000134	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627000135	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627000136	active site
1198627000137	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1198627000138	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627000139	DNA-binding site [nucleotide binding]; DNA binding site
1198627000140	FCD domain; Region: FCD; cl11656
1198627000141	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1198627000142	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1198627000143	active site residue [active]
1198627000144	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1198627000145	active site residue [active]
1198627000146	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1198627000147	classical (c) SDRs; Region: SDR_c; cd05233
1198627000148	NAD(P) binding site [chemical binding]; other site
1198627000149	active site
1198627000150	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1198627000151	classical (c) SDRs; Region: SDR_c; cd05233
1198627000152	NAD(P) binding site [chemical binding]; other site
1198627000153	active site
1198627000154	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627000155	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627000156	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627000157	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627000158	active site
1198627000159	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
1198627000160	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
1198627000161	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
1198627000162	active site
1198627000163	Fe binding site [ion binding]; other site
1198627000164	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1198627000165	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1198627000166	Bacterial transcriptional regulator; Region: IclR; pfam01614
1198627000167	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627000168	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627000169	substrate binding pocket [chemical binding]; other site
1198627000170	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1198627000171	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
1198627000172	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845
1198627000173	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1198627000174	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627000175	MarR family; Region: MarR; pfam01047
1198627000176	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627000177	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627000178	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1198627000179	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1198627000180	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1198627000181	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1198627000182	FMN-binding pocket [chemical binding]; other site
1198627000183	flavin binding motif; other site
1198627000184	phosphate binding motif [ion binding]; other site
1198627000185	beta-alpha-beta structure motif; other site
1198627000186	NAD binding pocket [chemical binding]; other site
1198627000187	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627000188	catalytic loop [active]
1198627000189	iron binding site [ion binding]; other site
1198627000190	short chain dehydrogenase; Provisional; Region: PRK07832
1198627000191	classical (c) SDRs; Region: SDR_c; cd05233
1198627000192	NAD(P) binding site [chemical binding]; other site
1198627000193	active site
1198627000194	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1198627000195	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1198627000196	dimer interface [polypeptide binding]; other site
1198627000197	active site
1198627000198	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1198627000199	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1198627000200	active site
1198627000201	FMN binding site [chemical binding]; other site
1198627000202	substrate binding site [chemical binding]; other site
1198627000203	3Fe-4S cluster binding site [ion binding]; other site
1198627000204	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1198627000205	domain interface; other site
1198627000206	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1198627000207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1198627000208	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1198627000209	active site
1198627000210	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1198627000211	hypothetical protein; Provisional; Region: PRK07945
1198627000212	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1198627000213	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1198627000214	active site
1198627000215	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627000216	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627000217	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1198627000218	classical (c) SDRs; Region: SDR_c; cd05233
1198627000219	NAD(P) binding site [chemical binding]; other site
1198627000220	active site
1198627000221	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627000222	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627000223	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627000224	substrate binding site [chemical binding]; other site
1198627000225	oxyanion hole (OAH) forming residues; other site
1198627000226	trimer interface [polypeptide binding]; other site
1198627000227	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1198627000228	FAD binding domain; Region: FAD_binding_4; pfam01565
1198627000229	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1198627000230	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1198627000231	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1198627000232	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1198627000233	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1198627000234	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1198627000235	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1198627000236	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1198627000237	active site residue [active]
1198627000238	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1198627000239	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
1198627000240	putative active site [active]
1198627000241	catalytic site [active]
1198627000242	putative metal binding site [ion binding]; other site
1198627000243	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1198627000244	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1198627000245	metal binding site [ion binding]; metal-binding site
1198627000246	active site
1198627000247	I-site; other site
1198627000248	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627000249	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1198627000250	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1198627000251	Ferritin-like domain; Region: Ferritin; pfam00210
1198627000252	ferroxidase diiron center [ion binding]; other site
1198627000253	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1198627000254	Ferritin-like domain; Region: Ferritin; pfam00210
1198627000255	ferroxidase diiron center [ion binding]; other site
1198627000256	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
1198627000257	prephenate dehydratase; Provisional; Region: PRK11898
1198627000258	Prephenate dehydratase; Region: PDT; pfam00800
1198627000259	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1198627000260	putative L-Phe binding site [chemical binding]; other site
1198627000261	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627000262	catalytic core [active]
1198627000263	pyruvate dehydrogenase; Provisional; Region: PRK09124
1198627000264	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1198627000265	PYR/PP interface [polypeptide binding]; other site
1198627000266	dimer interface [polypeptide binding]; other site
1198627000267	tetramer interface [polypeptide binding]; other site
1198627000268	TPP binding site [chemical binding]; other site
1198627000269	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1198627000270	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1198627000271	TPP-binding site [chemical binding]; other site
1198627000272	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627000273	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627000274	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627000275	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627000276	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627000277	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627000278	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1198627000279	classical (c) SDRs; Region: SDR_c; cd05233
1198627000280	NAD(P) binding site [chemical binding]; other site
1198627000281	active site
1198627000282	short chain dehydrogenase; Provisional; Region: PRK07832
1198627000283	classical (c) SDRs; Region: SDR_c; cd05233
1198627000284	NAD(P) binding site [chemical binding]; other site
1198627000285	active site
1198627000286	MgtC family; Region: MgtC; pfam02308
1198627000287	Septum formation; Region: Septum_form; pfam13845
1198627000288	Septum formation; Region: Septum_form; pfam13845
1198627000289	seryl-tRNA synthetase; Provisional; Region: PRK05431
1198627000290	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1198627000291	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1198627000292	dimer interface [polypeptide binding]; other site
1198627000293	active site
1198627000294	motif 1; other site
1198627000295	motif 2; other site
1198627000296	motif 3; other site
1198627000297	Domain of unknown function (DUF385); Region: DUF385; cl04387
1198627000298	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1198627000299	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1198627000300	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1198627000301	iron-sulfur cluster [ion binding]; other site
1198627000302	[2Fe-2S] cluster binding site [ion binding]; other site
1198627000303	Nitronate monooxygenase; Region: NMO; pfam03060
1198627000304	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1198627000305	FMN binding site [chemical binding]; other site
1198627000306	substrate binding site [chemical binding]; other site
1198627000307	putative catalytic residue [active]
1198627000308	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1198627000309	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627000310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627000311	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1198627000312	putative dimerization interface [polypeptide binding]; other site
1198627000313	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1198627000314	active site
1198627000315	ATP binding site [chemical binding]; other site
1198627000316	Phosphotransferase enzyme family; Region: APH; pfam01636
1198627000317	antibiotic binding site [chemical binding]; other site
1198627000318	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1198627000319	classical (c) SDRs; Region: SDR_c; cd05233
1198627000320	NAD(P) binding site [chemical binding]; other site
1198627000321	active site
1198627000322	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1198627000323	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1198627000324	putative acyl-acceptor binding pocket; other site
1198627000325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627000326	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1198627000327	active site
1198627000328	motif I; other site
1198627000329	motif II; other site
1198627000330	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627000331	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1198627000332	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1198627000333	UDP-galactopyranose mutase; Region: GLF; pfam03275
1198627000334	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1198627000335	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1198627000336	active site
1198627000337	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1198627000338	UbiA prenyltransferase family; Region: UbiA; pfam01040
1198627000339	Putative esterase; Region: Esterase; pfam00756
1198627000340	Putative esterase; Region: Esterase; pfam00756
1198627000341	Predicted esterase [General function prediction only]; Region: COG0627
1198627000342	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1198627000343	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627000344	acyl-activating enzyme (AAE) consensus motif; other site
1198627000345	active site
1198627000346	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1198627000347	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1198627000348	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1198627000349	active site
1198627000350	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1198627000351	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1198627000352	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1198627000353	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1198627000354	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1198627000355	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1198627000356	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1198627000357	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
1198627000358	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
1198627000359	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1198627000360	classical (c) SDRs; Region: SDR_c; cd05233
1198627000361	NAD(P) binding site [chemical binding]; other site
1198627000362	active site
1198627000363	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1198627000364	FAD binding domain; Region: FAD_binding_4; pfam01565
1198627000365	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1198627000366	Predicted membrane protein [Function unknown]; Region: COG2246
1198627000367	GtrA-like protein; Region: GtrA; pfam04138
1198627000368	dihydroxyacetone kinase; Provisional; Region: PRK14479
1198627000369	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1198627000370	DAK2 domain; Region: Dak2; pfam02734
1198627000371	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627000372	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1198627000373	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627000374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627000375	homodimer interface [polypeptide binding]; other site
1198627000376	catalytic residue [active]
1198627000377	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1198627000378	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1198627000379	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1198627000380	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1198627000381	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1198627000382	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1198627000383	active site
1198627000384	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1198627000385	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1198627000386	Walker A/P-loop; other site
1198627000387	ATP binding site [chemical binding]; other site
1198627000388	Q-loop/lid; other site
1198627000389	ABC transporter signature motif; other site
1198627000390	Walker B; other site
1198627000391	D-loop; other site
1198627000392	H-loop/switch region; other site
1198627000393	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
1198627000394	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1198627000395	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627000396	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627000397	catalytic residue [active]
1198627000398	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1198627000399	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1198627000400	NAD(P) binding site [chemical binding]; other site
1198627000401	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627000402	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627000403	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1198627000404	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1198627000405	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627000406	catalytic residue [active]
1198627000407	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1198627000408	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627000409	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627000410	homodimer interface [polypeptide binding]; other site
1198627000411	catalytic residue [active]
1198627000412	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1198627000413	choline dehydrogenase; Validated; Region: PRK02106
1198627000414	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1198627000415	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627000416	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627000417	active site
1198627000418	short chain dehydrogenase; Provisional; Region: PRK07890
1198627000419	classical (c) SDRs; Region: SDR_c; cd05233
1198627000420	NAD(P) binding site [chemical binding]; other site
1198627000421	active site
1198627000422	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1198627000423	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1198627000424	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1198627000425	Walker A/P-loop; other site
1198627000426	ATP binding site [chemical binding]; other site
1198627000427	Q-loop/lid; other site
1198627000428	ABC transporter signature motif; other site
1198627000429	Walker B; other site
1198627000430	D-loop; other site
1198627000431	H-loop/switch region; other site
1198627000432	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1198627000433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627000434	ABC-ATPase subunit interface; other site
1198627000435	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1198627000436	nucleoside/Zn binding site; other site
1198627000437	dimer interface [polypeptide binding]; other site
1198627000438	catalytic motif [active]
1198627000439	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627000440	Cytochrome P450; Region: p450; cl12078
1198627000441	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1198627000442	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1198627000443	substrate binding pocket [chemical binding]; other site
1198627000444	membrane-bound complex binding site; other site
1198627000445	hinge residues; other site
1198627000446	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1198627000447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627000448	dimer interface [polypeptide binding]; other site
1198627000449	conserved gate region; other site
1198627000450	putative PBP binding loops; other site
1198627000451	ABC-ATPase subunit interface; other site
1198627000452	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1198627000453	active site
1198627000454	HIGH motif; other site
1198627000455	nucleotide binding site [chemical binding]; other site
1198627000456	active site
1198627000457	KMSKS motif; other site
1198627000458	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1198627000459	nucleotide binding site [chemical binding]; other site
1198627000460	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1198627000461	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1198627000462	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
1198627000463	NAD(P) binding site [chemical binding]; other site
1198627000464	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1198627000465	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627000466	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627000467	acyl-activating enzyme (AAE) consensus motif; other site
1198627000468	acyl-activating enzyme (AAE) consensus motif; other site
1198627000469	AMP binding site [chemical binding]; other site
1198627000470	active site
1198627000471	CoA binding site [chemical binding]; other site
1198627000472	salicylate hydroxylase; Provisional; Region: PRK08163
1198627000473	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1198627000474	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1198627000475	tetramer interface [polypeptide binding]; other site
1198627000476	active site
1198627000477	Carboxylesterase family; Region: COesterase; pfam00135
1198627000478	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627000479	substrate binding pocket [chemical binding]; other site
1198627000480	catalytic triad [active]
1198627000481	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1198627000482	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
1198627000483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627000484	NAD(P) binding site [chemical binding]; other site
1198627000485	active site
1198627000486	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1198627000487	Isochorismatase family; Region: Isochorismatase; pfam00857
1198627000488	catalytic triad [active]
1198627000489	conserved cis-peptide bond; other site
1198627000490	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1198627000491	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1198627000492	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1198627000493	glutamine binding [chemical binding]; other site
1198627000494	catalytic triad [active]
1198627000495	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1198627000496	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627000497	substrate binding pocket [chemical binding]; other site
1198627000498	catalytic triad [active]
1198627000499	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1198627000500	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627000501	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627000502	catalytic residue [active]
1198627000503	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1198627000504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627000505	Walker A motif; other site
1198627000506	ATP binding site [chemical binding]; other site
1198627000507	Walker B motif; other site
1198627000508	arginine finger; other site
1198627000509	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1198627000510	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1198627000511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627000512	S-adenosylmethionine binding site [chemical binding]; other site
1198627000513	enolase; Provisional; Region: eno; PRK00077
1198627000514	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1198627000515	metal binding site [ion binding]; metal-binding site
1198627000516	substrate binding pocket [chemical binding]; other site
1198627000517	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627000518	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627000519	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627000520	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1198627000521	substrate binding site [chemical binding]; other site
1198627000522	oxyanion hole (OAH) forming residues; other site
1198627000523	trimer interface [polypeptide binding]; other site
1198627000524	recombination protein RecR; Reviewed; Region: recR; PRK00076
1198627000525	RecR protein; Region: RecR; pfam02132
1198627000526	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1198627000527	putative active site [active]
1198627000528	putative metal-binding site [ion binding]; other site
1198627000529	tetramer interface [polypeptide binding]; other site
1198627000530	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627000531	MarR family; Region: MarR_2; pfam12802
1198627000532	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627000533	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1198627000534	active site
1198627000535	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
1198627000536	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1198627000537	active site
1198627000538	catalytic site [active]
1198627000539	substrate binding site [chemical binding]; other site
1198627000540	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
1198627000541	Dimer interface [polypeptide binding]; other site
1198627000542	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1198627000543	Beta-lactamase; Region: Beta-lactamase; pfam00144
1198627000544	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1198627000545	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1198627000546	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1198627000547	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1198627000548	2-isopropylmalate synthase; Validated; Region: PRK03739
1198627000549	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1198627000550	active site
1198627000551	catalytic residues [active]
1198627000552	metal binding site [ion binding]; metal-binding site
1198627000553	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1198627000554	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1198627000555	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1198627000556	FMN binding site [chemical binding]; other site
1198627000557	dimer interface [polypeptide binding]; other site
1198627000558	aspartate kinase; Reviewed; Region: PRK06635
1198627000559	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1198627000560	putative nucleotide binding site [chemical binding]; other site
1198627000561	putative catalytic residues [active]
1198627000562	putative Mg ion binding site [ion binding]; other site
1198627000563	putative aspartate binding site [chemical binding]; other site
1198627000564	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1198627000565	putative allosteric regulatory site; other site
1198627000566	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1198627000567	putative allosteric regulatory residue; other site
1198627000568	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1198627000569	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1198627000570	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1198627000571	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
1198627000572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627000573	ATP binding site [chemical binding]; other site
1198627000574	Walker B motif; other site
1198627000575	arginine finger; other site
1198627000576	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1198627000577	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1198627000578	TAP-like protein; Region: Abhydrolase_4; pfam08386
1198627000579	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1198627000580	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1198627000581	tetramer interface [polypeptide binding]; other site
1198627000582	heme binding pocket [chemical binding]; other site
1198627000583	NADPH binding site [chemical binding]; other site
1198627000584	Nitronate monooxygenase; Region: NMO; pfam03060
1198627000585	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1198627000586	FMN binding site [chemical binding]; other site
1198627000587	substrate binding site [chemical binding]; other site
1198627000588	putative catalytic residue [active]
1198627000589	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1198627000590	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1198627000591	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627000592	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1198627000593	active site
1198627000594	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1198627000595	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1198627000596	dimer interface [polypeptide binding]; other site
1198627000597	active site
1198627000598	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1198627000599	dimer interface [polypeptide binding]; other site
1198627000600	active site
1198627000601	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1198627000602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627000603	putative substrate translocation pore; other site
1198627000604	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1198627000605	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627000606	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1198627000607	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627000608	NAD(P) binding site [chemical binding]; other site
1198627000609	active site
1198627000610	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1198627000611	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
1198627000612	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1198627000613	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
1198627000614	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1198627000615	putative active site [active]
1198627000616	putative dimer interface [polypeptide binding]; other site
1198627000617	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
1198627000618	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1198627000619	ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343
1198627000620	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1198627000621	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627000622	catalytic residue [active]
1198627000623	short chain dehydrogenase; Provisional; Region: PRK07791
1198627000624	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627000625	NAD(P) binding site [chemical binding]; other site
1198627000626	active site
1198627000627	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1198627000628	amphipathic channel; other site
1198627000629	Asn-Pro-Ala signature motifs; other site
1198627000630	glycerol kinase; Provisional; Region: glpK; PRK00047
1198627000631	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
1198627000632	N- and C-terminal domain interface [polypeptide binding]; other site
1198627000633	active site
1198627000634	MgATP binding site [chemical binding]; other site
1198627000635	catalytic site [active]
1198627000636	metal binding site [ion binding]; metal-binding site
1198627000637	putative homotetramer interface [polypeptide binding]; other site
1198627000638	glycerol binding site [chemical binding]; other site
1198627000639	homodimer interface [polypeptide binding]; other site
1198627000640	MoxR-like ATPases [General function prediction only]; Region: COG0714
1198627000641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627000642	Walker A motif; other site
1198627000643	ATP binding site [chemical binding]; other site
1198627000644	Walker B motif; other site
1198627000645	arginine finger; other site
1198627000646	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1198627000647	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1198627000648	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1198627000649	active site
1198627000650	AAA domain; Region: AAA_30; pfam13604
1198627000651	Family description; Region: UvrD_C_2; pfam13538
1198627000652	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
1198627000653	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
1198627000654	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1198627000655	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1198627000656	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1198627000657	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627000658	catalytic residue [active]
1198627000659	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1198627000660	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1198627000661	putative active site [active]
1198627000662	putative metal binding site [ion binding]; other site
1198627000663	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1198627000664	Transglycosylase; Region: Transgly; pfam00912
1198627000665	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1198627000666	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1198627000667	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1198627000668	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1198627000669	DTAP/Switch II; other site
1198627000670	Switch I; other site
1198627000671	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1198627000672	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1198627000673	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1198627000674	P loop; other site
1198627000675	Nucleotide binding site [chemical binding]; other site
1198627000676	DTAP/Switch II; other site
1198627000677	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1198627000678	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1198627000679	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1198627000680	ligand binding site [chemical binding]; other site
1198627000681	flexible hinge region; other site
1198627000682	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1198627000683	putative switch regulator; other site
1198627000684	non-specific DNA interactions [nucleotide binding]; other site
1198627000685	DNA binding site [nucleotide binding]
1198627000686	sequence specific DNA binding site [nucleotide binding]; other site
1198627000687	putative cAMP binding site [chemical binding]; other site
1198627000688	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1198627000689	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1198627000690	minor groove reading motif; other site
1198627000691	helix-hairpin-helix signature motif; other site
1198627000692	substrate binding pocket [chemical binding]; other site
1198627000693	active site
1198627000694	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1198627000695	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1198627000696	putative active site [active]
1198627000697	putative CoA binding site [chemical binding]; other site
1198627000698	nudix motif; other site
1198627000699	metal binding site [ion binding]; metal-binding site
1198627000700	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1198627000701	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1198627000702	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627000703	PGAP1-like protein; Region: PGAP1; pfam07819
1198627000704	acetyl-CoA synthetase; Provisional; Region: PRK00174
1198627000705	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1198627000706	active site
1198627000707	CoA binding site [chemical binding]; other site
1198627000708	acyl-activating enzyme (AAE) consensus motif; other site
1198627000709	AMP binding site [chemical binding]; other site
1198627000710	acetate binding site [chemical binding]; other site
1198627000711	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1198627000712	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1198627000713	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1198627000714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627000715	dimer interface [polypeptide binding]; other site
1198627000716	conserved gate region; other site
1198627000717	putative PBP binding loops; other site
1198627000718	ABC-ATPase subunit interface; other site
1198627000719	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1198627000720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627000721	dimer interface [polypeptide binding]; other site
1198627000722	conserved gate region; other site
1198627000723	putative PBP binding loops; other site
1198627000724	ABC-ATPase subunit interface; other site
1198627000725	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1198627000726	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1198627000727	Walker A/P-loop; other site
1198627000728	ATP binding site [chemical binding]; other site
1198627000729	Q-loop/lid; other site
1198627000730	ABC transporter signature motif; other site
1198627000731	Walker B; other site
1198627000732	D-loop; other site
1198627000733	H-loop/switch region; other site
1198627000734	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1198627000735	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1198627000736	Walker A/P-loop; other site
1198627000737	ATP binding site [chemical binding]; other site
1198627000738	Q-loop/lid; other site
1198627000739	ABC transporter signature motif; other site
1198627000740	Walker B; other site
1198627000741	D-loop; other site
1198627000742	H-loop/switch region; other site
1198627000743	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1198627000744	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1198627000745	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627000746	motif II; other site
1198627000747	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1198627000748	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1198627000749	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1198627000750	Walker A motif; other site
1198627000751	ATP binding site [chemical binding]; other site
1198627000752	Walker B motif; other site
1198627000753	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1198627000754	active site
1198627000755	Int/Topo IB signature motif; other site
1198627000756	catalytic residues [active]
1198627000757	DNA binding site [nucleotide binding]
1198627000758	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1198627000759	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1198627000760	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627000761	motif II; other site
1198627000762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627000763	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627000764	putative substrate translocation pore; other site
1198627000765	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1198627000766	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1198627000767	dimer interface [polypeptide binding]; other site
1198627000768	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627000769	catalytic residue [active]
1198627000770	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1198627000771	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1198627000772	NodB motif; other site
1198627000773	active site
1198627000774	catalytic site [active]
1198627000775	metal binding site [ion binding]; metal-binding site
1198627000776	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
1198627000777	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1198627000778	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1198627000779	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1198627000780	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1198627000781	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
1198627000782	active site clefts [active]
1198627000783	zinc binding site [ion binding]; other site
1198627000784	dimer interface [polypeptide binding]; other site
1198627000785	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627000786	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627000787	Transport protein; Region: actII; TIGR00833
1198627000788	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1198627000789	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627000790	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1198627000791	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1198627000792	active site
1198627000793	FMN binding site [chemical binding]; other site
1198627000794	substrate binding site [chemical binding]; other site
1198627000795	homotetramer interface [polypeptide binding]; other site
1198627000796	catalytic residue [active]
1198627000797	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1198627000798	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1198627000799	ATP binding site [chemical binding]; other site
1198627000800	putative Mg++ binding site [ion binding]; other site
1198627000801	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1198627000802	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1198627000803	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1198627000804	active site
1198627000805	interdomain interaction site; other site
1198627000806	putative metal-binding site [ion binding]; other site
1198627000807	nucleotide binding site [chemical binding]; other site
1198627000808	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
1198627000809	domain I; other site
1198627000810	phosphate binding site [ion binding]; other site
1198627000811	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1198627000812	domain II; other site
1198627000813	domain III; other site
1198627000814	nucleotide binding site [chemical binding]; other site
1198627000815	DNA binding groove [nucleotide binding]
1198627000816	catalytic site [active]
1198627000817	domain IV; other site
1198627000818	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1198627000819	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1198627000820	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1198627000821	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1198627000822	dimerization interface [polypeptide binding]; other site
1198627000823	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1198627000824	cyclase homology domain; Region: CHD; cd07302
1198627000825	nucleotidyl binding site; other site
1198627000826	metal binding site [ion binding]; metal-binding site
1198627000827	dimer interface [polypeptide binding]; other site
1198627000828	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1198627000829	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1198627000830	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1198627000831	Predicted acyl esterases [General function prediction only]; Region: COG2936
1198627000832	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1198627000833	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1198627000834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627000835	NAD(P) binding site [chemical binding]; other site
1198627000836	active site
1198627000837	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1198627000838	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1198627000839	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627000840	acyl-activating enzyme (AAE) consensus motif; other site
1198627000841	AMP binding site [chemical binding]; other site
1198627000842	active site
1198627000843	CoA binding site [chemical binding]; other site
1198627000844	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627000845	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1198627000846	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1198627000847	putative trimer interface [polypeptide binding]; other site
1198627000848	putative CoA binding site [chemical binding]; other site
1198627000849	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1198627000850	putative trimer interface [polypeptide binding]; other site
1198627000851	putative CoA binding site [chemical binding]; other site
1198627000852	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1198627000853	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1198627000854	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627000855	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627000856	catalytic residue [active]
1198627000857	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627000858	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627000859	classical (c) SDRs; Region: SDR_c; cd05233
1198627000860	NAD(P) binding site [chemical binding]; other site
1198627000861	active site
1198627000862	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1198627000863	dimer interface [polypeptide binding]; other site
1198627000864	substrate binding site [chemical binding]; other site
1198627000865	metal binding sites [ion binding]; metal-binding site
1198627000866	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1198627000867	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1198627000868	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627000869	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627000870	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627000871	active site
1198627000872	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1198627000873	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1198627000874	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
1198627000875	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1198627000876	putative NAD(P) binding site [chemical binding]; other site
1198627000877	catalytic Zn binding site [ion binding]; other site
1198627000878	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1198627000879	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1198627000880	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627000881	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1198627000882	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1198627000883	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1198627000884	metal ion-dependent adhesion site (MIDAS); other site
1198627000885	FtsH Extracellular; Region: FtsH_ext; pfam06480
1198627000886	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1198627000887	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627000888	Walker A motif; other site
1198627000889	ATP binding site [chemical binding]; other site
1198627000890	Walker B motif; other site
1198627000891	arginine finger; other site
1198627000892	Peptidase family M41; Region: Peptidase_M41; pfam01434
1198627000893	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1198627000894	homodecamer interface [polypeptide binding]; other site
1198627000895	GTP cyclohydrolase I; Provisional; Region: PLN03044
1198627000896	active site
1198627000897	putative catalytic site residues [active]
1198627000898	zinc binding site [ion binding]; other site
1198627000899	GTP-CH-I/GFRP interaction surface; other site
1198627000900	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1198627000901	dihydropteroate synthase; Region: DHPS; TIGR01496
1198627000902	substrate binding pocket [chemical binding]; other site
1198627000903	dimer interface [polypeptide binding]; other site
1198627000904	inhibitor binding site; inhibition site
1198627000905	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1198627000906	homooctamer interface [polypeptide binding]; other site
1198627000907	active site
1198627000908	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1198627000909	catalytic center binding site [active]
1198627000910	ATP binding site [chemical binding]; other site
1198627000911	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1198627000912	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1198627000913	active site
1198627000914	ATP-binding site [chemical binding]; other site
1198627000915	pantoate-binding site; other site
1198627000916	HXXH motif; other site
1198627000917	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1198627000918	tetramerization interface [polypeptide binding]; other site
1198627000919	active site
1198627000920	pantothenate kinase; Reviewed; Region: PRK13318
1198627000921	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1198627000922	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1198627000923	dimer interface [polypeptide binding]; other site
1198627000924	putative anticodon binding site; other site
1198627000925	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1198627000926	motif 1; other site
1198627000927	dimer interface [polypeptide binding]; other site
1198627000928	active site
1198627000929	motif 2; other site
1198627000930	motif 3; other site
1198627000931	Lsr2; Region: Lsr2; pfam11774
1198627000932	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1198627000933	Clp amino terminal domain; Region: Clp_N; pfam02861
1198627000934	Clp amino terminal domain; Region: Clp_N; pfam02861
1198627000935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627000936	Walker A motif; other site
1198627000937	ATP binding site [chemical binding]; other site
1198627000938	Walker B motif; other site
1198627000939	arginine finger; other site
1198627000940	UvrB/uvrC motif; Region: UVR; pfam02151
1198627000941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627000942	Walker A motif; other site
1198627000943	ATP binding site [chemical binding]; other site
1198627000944	Walker B motif; other site
1198627000945	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1198627000946	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1198627000947	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1198627000948	Walker A/P-loop; other site
1198627000949	ATP binding site [chemical binding]; other site
1198627000950	Q-loop/lid; other site
1198627000951	ABC transporter signature motif; other site
1198627000952	Walker B; other site
1198627000953	D-loop; other site
1198627000954	H-loop/switch region; other site
1198627000955	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1198627000956	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1198627000957	ABC-ATPase subunit  interface; other site
1198627000958	dimer interface [polypeptide binding]; other site
1198627000959	putative PBP binding regions; other site
1198627000960	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1198627000961	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1198627000962	endonuclease III; Region: ENDO3c; smart00478
1198627000963	minor groove reading motif; other site
1198627000964	helix-hairpin-helix signature motif; other site
1198627000965	substrate binding pocket [chemical binding]; other site
1198627000966	active site
1198627000967	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1198627000968	active site clefts [active]
1198627000969	zinc binding site [ion binding]; other site
1198627000970	dimer interface [polypeptide binding]; other site
1198627000971	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1198627000972	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1198627000973	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1198627000974	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1198627000975	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1198627000976	DNA repair protein RadA; Provisional; Region: PRK11823
1198627000977	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1198627000978	Walker A motif; other site
1198627000979	ATP binding site [chemical binding]; other site
1198627000980	Walker B motif; other site
1198627000981	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1198627000982	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1198627000983	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1198627000984	homotrimer interaction site [polypeptide binding]; other site
1198627000985	zinc binding site [ion binding]; other site
1198627000986	CDP-binding sites; other site
1198627000987	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1198627000988	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1198627000989	active site
1198627000990	HIGH motif; other site
1198627000991	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1198627000992	KMSKS motif; other site
1198627000993	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1198627000994	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1198627000995	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1198627000996	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1198627000997	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1198627000998	putative active site [active]
1198627000999	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1198627001000	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1198627001001	dimer interface [polypeptide binding]; other site
1198627001002	putative PBP binding regions; other site
1198627001003	ABC-ATPase subunit  interface; other site
1198627001004	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1198627001005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627001006	Walker A/P-loop; other site
1198627001007	ATP binding site [chemical binding]; other site
1198627001008	Q-loop/lid; other site
1198627001009	ABC transporter signature motif; other site
1198627001010	Walker B; other site
1198627001011	D-loop; other site
1198627001012	H-loop/switch region; other site
1198627001013	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1198627001014	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1198627001015	intersubunit interface [polypeptide binding]; other site
1198627001016	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1198627001017	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1198627001018	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627001019	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627001020	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001021	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1198627001022	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001023	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001024	active site
1198627001025	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1198627001026	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1198627001027	FAD binding pocket [chemical binding]; other site
1198627001028	FAD binding motif [chemical binding]; other site
1198627001029	phosphate binding motif [ion binding]; other site
1198627001030	beta-alpha-beta structure motif; other site
1198627001031	NAD(p) ribose binding residues [chemical binding]; other site
1198627001032	NAD binding pocket [chemical binding]; other site
1198627001033	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1198627001034	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627001035	catalytic loop [active]
1198627001036	iron binding site [ion binding]; other site
1198627001037	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001038	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
1198627001039	Flavin binding site [chemical binding]; other site
1198627001040	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
1198627001041	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
1198627001042	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
1198627001043	active site
1198627001044	Fe binding site [ion binding]; other site
1198627001045	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1198627001046	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
1198627001047	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1198627001048	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1198627001049	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1198627001050	amphipathic channel; other site
1198627001051	Asn-Pro-Ala signature motifs; other site
1198627001052	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1198627001053	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001054	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001055	active site
1198627001056	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001057	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001058	active site
1198627001059	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1198627001060	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1198627001061	acyl-activating enzyme (AAE) consensus motif; other site
1198627001062	putative AMP binding site [chemical binding]; other site
1198627001063	putative active site [active]
1198627001064	putative CoA binding site [chemical binding]; other site
1198627001065	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001066	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001067	active site
1198627001068	short chain dehydrogenase; Provisional; Region: PRK07831
1198627001069	classical (c) SDRs; Region: SDR_c; cd05233
1198627001070	NAD(P) binding site [chemical binding]; other site
1198627001071	active site
1198627001072	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627001073	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627001074	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
1198627001075	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627001076	dimer interface [polypeptide binding]; other site
1198627001077	active site
1198627001078	Nitronate monooxygenase; Region: NMO; pfam03060
1198627001079	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1198627001080	FMN binding site [chemical binding]; other site
1198627001081	substrate binding site [chemical binding]; other site
1198627001082	putative catalytic residue [active]
1198627001083	Coenzyme A transferase; Region: CoA_trans; cl17247
1198627001084	Coenzyme A transferase; Region: CoA_trans; cl17247
1198627001085	enoyl-CoA hydratase; Provisional; Region: PRK06495
1198627001086	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001087	substrate binding site [chemical binding]; other site
1198627001088	oxyanion hole (OAH) forming residues; other site
1198627001089	trimer interface [polypeptide binding]; other site
1198627001090	short chain dehydrogenase; Provisional; Region: PRK07856
1198627001091	classical (c) SDRs; Region: SDR_c; cd05233
1198627001092	NAD(P) binding site [chemical binding]; other site
1198627001093	active site
1198627001094	short chain dehydrogenase; Provisional; Region: PRK07791
1198627001095	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1198627001096	homodimer interface [polypeptide binding]; other site
1198627001097	NAD binding site [chemical binding]; other site
1198627001098	active site
1198627001099	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1198627001100	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627001101	Cytochrome P450; Region: p450; cl12078
1198627001102	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
1198627001103	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627001104	dimer interface [polypeptide binding]; other site
1198627001105	active site
1198627001106	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627001107	Cytochrome P450; Region: p450; cl12078
1198627001108	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001109	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001110	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001111	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001112	active site
1198627001113	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
1198627001114	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1198627001115	hypothetical protein; Validated; Region: PRK07121
1198627001116	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1198627001117	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
1198627001118	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1198627001119	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1198627001120	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1198627001121	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1198627001122	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1198627001123	active site
1198627001124	catalytic residues [active]
1198627001125	metal binding site [ion binding]; metal-binding site
1198627001126	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1198627001127	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1198627001128	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1198627001129	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1198627001130	P-loop; other site
1198627001131	Magnesium ion binding site [ion binding]; other site
1198627001132	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1198627001133	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
1198627001134	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1198627001135	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
1198627001136	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
1198627001137	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1198627001138	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1198627001139	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1198627001140	Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073
1198627001141	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
1198627001142	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
1198627001143	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627001144	Walker A motif; other site
1198627001145	ATP binding site [chemical binding]; other site
1198627001146	Walker B motif; other site
1198627001147	arginine finger; other site
1198627001148	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627001149	Walker A motif; other site
1198627001150	ATP binding site [chemical binding]; other site
1198627001151	Walker B motif; other site
1198627001152	arginine finger; other site
1198627001153	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1198627001154	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1198627001155	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1198627001156	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1198627001157	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1198627001158	dimer interface [polypeptide binding]; other site
1198627001159	putative functional site; other site
1198627001160	putative MPT binding site; other site
1198627001161	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1198627001162	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627001163	active site
1198627001164	motif I; other site
1198627001165	motif II; other site
1198627001166	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627001167	short chain dehydrogenase; Provisional; Region: PRK06197
1198627001168	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1198627001169	putative NAD(P) binding site [chemical binding]; other site
1198627001170	active site
1198627001171	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1198627001172	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1198627001173	ATP binding site [chemical binding]; other site
1198627001174	putative Mg++ binding site [ion binding]; other site
1198627001175	short chain dehydrogenase; Provisional; Region: PRK06197
1198627001176	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1198627001177	putative NAD(P) binding site [chemical binding]; other site
1198627001178	active site
1198627001179	hypothetical protein; Provisional; Region: PRK07236
1198627001180	hypothetical protein; Validated; Region: PRK05868
1198627001181	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1198627001182	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1198627001183	ring oligomerisation interface [polypeptide binding]; other site
1198627001184	ATP/Mg binding site [chemical binding]; other site
1198627001185	stacking interactions; other site
1198627001186	hinge regions; other site
1198627001187	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
1198627001188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1198627001189	MoxR-like ATPases [General function prediction only]; Region: COG0714
1198627001190	Protein of unknown function DUF58; Region: DUF58; pfam01882
1198627001191	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1198627001192	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1198627001193	FcoT-like thioesterase domain; Region: FcoT; pfam10862
1198627001194	acyl-CoA synthetase; Validated; Region: PRK05857
1198627001195	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627001196	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627001197	acyl-activating enzyme (AAE) consensus motif; other site
1198627001198	acyl-activating enzyme (AAE) consensus motif; other site
1198627001199	AMP binding site [chemical binding]; other site
1198627001200	active site
1198627001201	CoA binding site [chemical binding]; other site
1198627001202	Condensation domain; Region: Condensation; pfam00668
1198627001203	AMP-binding enzyme; Region: AMP-binding; pfam00501
1198627001204	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627001205	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627001206	acyl-activating enzyme (AAE) consensus motif; other site
1198627001207	acyl-activating enzyme (AAE) consensus motif; other site
1198627001208	AMP binding site [chemical binding]; other site
1198627001209	active site
1198627001210	CoA binding site [chemical binding]; other site
1198627001211	thioester reductase domain; Region: Thioester-redct; TIGR01746
1198627001212	NAD(P) binding site [chemical binding]; other site
1198627001213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627001214	active site
1198627001215	active site
1198627001216	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627001217	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1198627001218	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1198627001219	PPE family; Region: PPE; pfam00823
1198627001220	Domain of unknown function (DUF202); Region: DUF202; cl09954
1198627001221	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627001222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627001223	active site
1198627001224	phosphorylation site [posttranslational modification]
1198627001225	intermolecular recognition site; other site
1198627001226	dimerization interface [polypeptide binding]; other site
1198627001227	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627001228	DNA binding site [nucleotide binding]
1198627001229	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1198627001230	HAMP domain; Region: HAMP; pfam00672
1198627001231	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627001232	dimer interface [polypeptide binding]; other site
1198627001233	phosphorylation site [posttranslational modification]
1198627001234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627001235	ATP binding site [chemical binding]; other site
1198627001236	Mg2+ binding site [ion binding]; other site
1198627001237	G-X-G motif; other site
1198627001238	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1198627001239	nucleotide binding site/active site [active]
1198627001240	HIT family signature motif; other site
1198627001241	catalytic residue [active]
1198627001242	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1198627001243	EamA-like transporter family; Region: EamA; pfam00892
1198627001244	EamA-like transporter family; Region: EamA; pfam00892
1198627001245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627001246	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627001247	putative DNA binding site [nucleotide binding]; other site
1198627001248	dimerization interface [polypeptide binding]; other site
1198627001249	putative Zn2+ binding site [ion binding]; other site
1198627001250	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1198627001251	putative dimerization interface [polypeptide binding]; other site
1198627001252	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627001253	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1198627001254	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1198627001255	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627001256	active site
1198627001257	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627001258	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627001259	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627001260	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1198627001261	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1198627001262	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1198627001263	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1198627001264	aspartate aminotransferase; Provisional; Region: PRK05764
1198627001265	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627001266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627001267	homodimer interface [polypeptide binding]; other site
1198627001268	catalytic residue [active]
1198627001269	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1198627001270	adenylosuccinate lyase; Region: purB; TIGR00928
1198627001271	tetramer interface [polypeptide binding]; other site
1198627001272	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1198627001273	ATP binding site [chemical binding]; other site
1198627001274	active site
1198627001275	substrate binding site [chemical binding]; other site
1198627001276	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1198627001277	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627001278	short chain dehydrogenase; Provisional; Region: PRK06940
1198627001279	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627001280	NAD(P) binding site [chemical binding]; other site
1198627001281	active site
1198627001282	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1198627001283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627001284	putative substrate translocation pore; other site
1198627001285	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1198627001286	catalytic residues [active]
1198627001287	dimer interface [polypeptide binding]; other site
1198627001288	FAD binding domain; Region: FAD_binding_2; pfam00890
1198627001289	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1198627001290	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1198627001291	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1198627001292	putative active site [active]
1198627001293	catalytic triad [active]
1198627001294	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
1198627001295	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1198627001296	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1198627001297	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1198627001298	active site
1198627001299	metal binding site [ion binding]; metal-binding site
1198627001300	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1198627001301	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1198627001302	dimerization interface [polypeptide binding]; other site
1198627001303	ATP binding site [chemical binding]; other site
1198627001304	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1198627001305	dimerization interface [polypeptide binding]; other site
1198627001306	ATP binding site [chemical binding]; other site
1198627001307	amidophosphoribosyltransferase; Provisional; Region: PRK07847
1198627001308	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1198627001309	active site
1198627001310	tetramer interface [polypeptide binding]; other site
1198627001311	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627001312	active site
1198627001313	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1198627001314	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1198627001315	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627001316	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1198627001317	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
1198627001318	putative NADP binding site [chemical binding]; other site
1198627001319	putative substrate binding site [chemical binding]; other site
1198627001320	active site
1198627001321	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1198627001322	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
1198627001323	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1198627001324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627001325	ABC-ATPase subunit interface; other site
1198627001326	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1198627001327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627001328	dimer interface [polypeptide binding]; other site
1198627001329	conserved gate region; other site
1198627001330	ABC-ATPase subunit interface; other site
1198627001331	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1198627001332	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1198627001333	Walker A/P-loop; other site
1198627001334	ATP binding site [chemical binding]; other site
1198627001335	Q-loop/lid; other site
1198627001336	ABC transporter signature motif; other site
1198627001337	Walker B; other site
1198627001338	D-loop; other site
1198627001339	H-loop/switch region; other site
1198627001340	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1198627001341	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1198627001342	Walker A/P-loop; other site
1198627001343	ATP binding site [chemical binding]; other site
1198627001344	Q-loop/lid; other site
1198627001345	ABC transporter signature motif; other site
1198627001346	Walker B; other site
1198627001347	D-loop; other site
1198627001348	H-loop/switch region; other site
1198627001349	amidase; Provisional; Region: PRK07869
1198627001350	Amidase; Region: Amidase; cl11426
1198627001351	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1198627001352	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1198627001353	iron-sulfur cluster [ion binding]; other site
1198627001354	[2Fe-2S] cluster binding site [ion binding]; other site
1198627001355	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1198627001356	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1198627001357	dimerization interface [polypeptide binding]; other site
1198627001358	putative ATP binding site [chemical binding]; other site
1198627001359	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1198627001360	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1198627001361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627001362	catalytic residue [active]
1198627001363	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1198627001364	heme-binding site [chemical binding]; other site
1198627001365	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
1198627001366	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1198627001367	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1198627001368	active site residue [active]
1198627001369	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1198627001370	active site residue [active]
1198627001371	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627001372	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627001373	DNA binding site [nucleotide binding]
1198627001374	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1198627001375	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1198627001376	Coenzyme A binding pocket [chemical binding]; other site
1198627001377	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1198627001378	PBP superfamily domain; Region: PBP_like_2; cl17296
1198627001379	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1198627001380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627001381	dimer interface [polypeptide binding]; other site
1198627001382	conserved gate region; other site
1198627001383	putative PBP binding loops; other site
1198627001384	ABC-ATPase subunit interface; other site
1198627001385	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1198627001386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627001387	dimer interface [polypeptide binding]; other site
1198627001388	conserved gate region; other site
1198627001389	putative PBP binding loops; other site
1198627001390	ABC-ATPase subunit interface; other site
1198627001391	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1198627001392	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1198627001393	Walker A/P-loop; other site
1198627001394	ATP binding site [chemical binding]; other site
1198627001395	Q-loop/lid; other site
1198627001396	ABC transporter signature motif; other site
1198627001397	Walker B; other site
1198627001398	D-loop; other site
1198627001399	H-loop/switch region; other site
1198627001400	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1198627001401	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1198627001402	putative NAD(P) binding site [chemical binding]; other site
1198627001403	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1198627001404	PhoU domain; Region: PhoU; pfam01895
1198627001405	PhoU domain; Region: PhoU; pfam01895
1198627001406	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1198627001407	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1198627001408	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1198627001409	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1198627001410	FMN binding site [chemical binding]; other site
1198627001411	active site
1198627001412	catalytic residues [active]
1198627001413	substrate binding site [chemical binding]; other site
1198627001414	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1198627001415	homodimer interface [polypeptide binding]; other site
1198627001416	putative substrate binding pocket [chemical binding]; other site
1198627001417	diiron center [ion binding]; other site
1198627001418	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1198627001419	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1198627001420	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1198627001421	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
1198627001422	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1198627001423	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1198627001424	oxidoreductase; Provisional; Region: PRK06196
1198627001425	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627001426	NAD(P) binding site [chemical binding]; other site
1198627001427	active site
1198627001428	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1198627001429	EamA-like transporter family; Region: EamA; pfam00892
1198627001430	putative sialic acid transporter; Provisional; Region: PRK12307
1198627001431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627001432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627001433	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1198627001434	PPE family; Region: PPE; pfam00823
1198627001435	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627001436	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1198627001437	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627001438	homodimer interface [polypeptide binding]; other site
1198627001439	catalytic residue [active]
1198627001440	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1198627001441	EamA-like transporter family; Region: EamA; pfam00892
1198627001442	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1198627001443	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1198627001444	Bacterial transcriptional regulator; Region: IclR; pfam01614
1198627001445	Amino acid permease; Region: AA_permease_2; pfam13520
1198627001446	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1198627001447	pyranose oxidase; Region: pyranose_ox; TIGR02462
1198627001448	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1198627001449	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1198627001450	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1198627001451	tetrameric interface [polypeptide binding]; other site
1198627001452	NAD binding site [chemical binding]; other site
1198627001453	catalytic residues [active]
1198627001454	substrate binding site [chemical binding]; other site
1198627001455	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1198627001456	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627001457	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1198627001458	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
1198627001459	putative active site [active]
1198627001460	catalytic triad [active]
1198627001461	putative dimer interface [polypeptide binding]; other site
1198627001462	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1198627001463	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
1198627001464	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
1198627001465	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627001466	inhibitor-cofactor binding pocket; inhibition site
1198627001467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627001468	catalytic residue [active]
1198627001469	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001470	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001471	active site
1198627001472	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1198627001473	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627001474	NAD(P) binding site [chemical binding]; other site
1198627001475	catalytic residues [active]
1198627001476	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1198627001477	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1198627001478	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627001479	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627001480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627001481	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1198627001482	NAD(P) binding site [chemical binding]; other site
1198627001483	active site
1198627001484	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1198627001485	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1198627001486	FMN binding site [chemical binding]; other site
1198627001487	active site
1198627001488	substrate binding site [chemical binding]; other site
1198627001489	catalytic residue [active]
1198627001490	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1198627001491	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1198627001492	FMN binding site [chemical binding]; other site
1198627001493	active site
1198627001494	substrate binding site [chemical binding]; other site
1198627001495	catalytic residue [active]
1198627001496	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1198627001497	classical (c) SDRs; Region: SDR_c; cd05233
1198627001498	NAD(P) binding site [chemical binding]; other site
1198627001499	active site
1198627001500	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001501	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1198627001502	substrate binding site [chemical binding]; other site
1198627001503	oxyanion hole (OAH) forming residues; other site
1198627001504	trimer interface [polypeptide binding]; other site
1198627001505	enoyl-CoA hydratase; Provisional; Region: PRK07799
1198627001506	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001507	substrate binding site [chemical binding]; other site
1198627001508	oxyanion hole (OAH) forming residues; other site
1198627001509	trimer interface [polypeptide binding]; other site
1198627001510	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1198627001511	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1198627001512	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627001513	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627001514	aminotransferase; Validated; Region: PRK07777
1198627001515	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627001516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627001517	homodimer interface [polypeptide binding]; other site
1198627001518	catalytic residue [active]
1198627001519	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1198627001520	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627001521	dimer interface [polypeptide binding]; other site
1198627001522	active site
1198627001523	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1198627001524	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001525	substrate binding site [chemical binding]; other site
1198627001526	oxyanion hole (OAH) forming residues; other site
1198627001527	trimer interface [polypeptide binding]; other site
1198627001528	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1198627001529	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1198627001530	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1198627001531	peptide synthase; Provisional; Region: PRK12316
1198627001532	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1198627001533	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1198627001534	hypothetical protein; Provisional; Region: PRK06834
1198627001535	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1198627001536	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1198627001537	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627001538	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1198627001539	trimer interface [polypeptide binding]; other site
1198627001540	dimer interface [polypeptide binding]; other site
1198627001541	putative active site [active]
1198627001542	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1198627001543	MPT binding site; other site
1198627001544	trimer interface [polypeptide binding]; other site
1198627001545	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1198627001546	MoaE homodimer interface [polypeptide binding]; other site
1198627001547	MoaD interaction [polypeptide binding]; other site
1198627001548	active site residues [active]
1198627001549	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1198627001550	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627001551	FeS/SAM binding site; other site
1198627001552	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1198627001553	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1198627001554	DNA-binding site [nucleotide binding]; DNA binding site
1198627001555	RNA-binding motif; other site
1198627001556	H+ Antiporter protein; Region: 2A0121; TIGR00900
1198627001557	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1198627001558	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627001559	MarR family; Region: MarR; pfam01047
1198627001560	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1198627001561	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1198627001562	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1198627001563	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1198627001564	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
1198627001565	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1198627001566	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1198627001567	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1198627001568	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1198627001569	dimer interface [polypeptide binding]; other site
1198627001570	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1198627001571	active site
1198627001572	Fe binding site [ion binding]; other site
1198627001573	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1198627001574	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1198627001575	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627001576	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1198627001577	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1198627001578	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1198627001579	E3 interaction surface; other site
1198627001580	lipoyl attachment site [posttranslational modification]; other site
1198627001581	e3 binding domain; Region: E3_binding; pfam02817
1198627001582	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1198627001583	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1198627001584	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1198627001585	alpha subunit interface [polypeptide binding]; other site
1198627001586	TPP binding site [chemical binding]; other site
1198627001587	heterodimer interface [polypeptide binding]; other site
1198627001588	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1198627001589	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1198627001590	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1198627001591	tetramer interface [polypeptide binding]; other site
1198627001592	TPP-binding site [chemical binding]; other site
1198627001593	heterodimer interface [polypeptide binding]; other site
1198627001594	phosphorylation loop region [posttranslational modification]
1198627001595	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1198627001596	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1198627001597	putative DNA binding site [nucleotide binding]; other site
1198627001598	putative Zn2+ binding site [ion binding]; other site
1198627001599	AsnC family; Region: AsnC_trans_reg; pfam01037
1198627001600	conserved hypothetical protein; Region: TIGR02118
1198627001601	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
1198627001602	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
1198627001603	substrate binding site [chemical binding]; other site
1198627001604	dimer interface [polypeptide binding]; other site
1198627001605	NADP binding site [chemical binding]; other site
1198627001606	catalytic residues [active]
1198627001607	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1198627001608	active site 2 [active]
1198627001609	active site 1 [active]
1198627001610	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627001611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627001612	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627001613	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1198627001614	dimer interface [polypeptide binding]; other site
1198627001615	active site
1198627001616	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1198627001617	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001618	substrate binding site [chemical binding]; other site
1198627001619	oxyanion hole (OAH) forming residues; other site
1198627001620	trimer interface [polypeptide binding]; other site
1198627001621	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1198627001622	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1198627001623	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1198627001624	enoyl-CoA hydratase; Provisional; Region: PRK08140
1198627001625	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001626	substrate binding site [chemical binding]; other site
1198627001627	oxyanion hole (OAH) forming residues; other site
1198627001628	trimer interface [polypeptide binding]; other site
1198627001629	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1198627001630	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
1198627001631	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1198627001632	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1198627001633	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1198627001634	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1198627001635	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1198627001636	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1198627001637	FAD binding pocket [chemical binding]; other site
1198627001638	FAD binding motif [chemical binding]; other site
1198627001639	phosphate binding motif [ion binding]; other site
1198627001640	beta-alpha-beta structure motif; other site
1198627001641	NAD(p) ribose binding residues [chemical binding]; other site
1198627001642	NAD binding pocket [chemical binding]; other site
1198627001643	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1198627001644	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627001645	catalytic loop [active]
1198627001646	iron binding site [ion binding]; other site
1198627001647	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627001648	acyl-activating enzyme (AAE) consensus motif; other site
1198627001649	AMP binding site [chemical binding]; other site
1198627001650	active site
1198627001651	CoA binding site [chemical binding]; other site
1198627001652	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1198627001653	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627001654	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1198627001655	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627001656	catalytic loop [active]
1198627001657	iron binding site [ion binding]; other site
1198627001658	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1198627001659	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1198627001660	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627001661	Cytochrome P450; Region: p450; cl12078
1198627001662	Secretory lipase; Region: LIP; pfam03583
1198627001663	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1198627001664	MarR family; Region: MarR; pfam01047
1198627001665	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1198627001666	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627001667	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627001668	catalytic residue [active]
1198627001669	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1198627001670	Ferredoxin [Energy production and conversion]; Region: COG1146
1198627001671	ferredoxin-NADP+ reductase; Region: PLN02852
1198627001672	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1198627001673	putative dimer interface [polypeptide binding]; other site
1198627001674	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1198627001675	citrate synthase 2; Provisional; Region: PRK12350
1198627001676	Citrate synthase; Region: Citrate_synt; pfam00285
1198627001677	oxalacetate binding site [chemical binding]; other site
1198627001678	citrylCoA binding site [chemical binding]; other site
1198627001679	coenzyme A binding site [chemical binding]; other site
1198627001680	catalytic triad [active]
1198627001681	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1198627001682	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1198627001683	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1198627001684	acyl-CoA synthetase; Validated; Region: PRK05850
1198627001685	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627001686	acyl-activating enzyme (AAE) consensus motif; other site
1198627001687	active site
1198627001688	PE-PPE domain; Region: PE-PPE; pfam08237
1198627001689	Transport protein; Region: actII; TIGR00833
1198627001690	Condensation domain; Region: Condensation; pfam00668
1198627001691	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1198627001692	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1198627001693	active site
1198627001694	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1198627001695	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1198627001696	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1198627001697	KR domain; Region: KR; pfam08659
1198627001698	putative NADP binding site [chemical binding]; other site
1198627001699	active site
1198627001700	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1198627001701	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1198627001702	active site
1198627001703	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1198627001704	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1198627001705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627001706	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1198627001707	Enoylreductase; Region: PKS_ER; smart00829
1198627001708	NAD(P) binding site [chemical binding]; other site
1198627001709	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1198627001710	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1198627001711	putative NADP binding site [chemical binding]; other site
1198627001712	active site
1198627001713	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1198627001714	H+ Antiporter protein; Region: 2A0121; TIGR00900
1198627001715	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627001716	putative substrate translocation pore; other site
1198627001717	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1198627001718	conserved cys residue [active]
1198627001719	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627001720	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1198627001721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627001722	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1198627001723	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1198627001724	dimer interface [polypeptide binding]; other site
1198627001725	active site
1198627001726	citrylCoA binding site [chemical binding]; other site
1198627001727	NADH binding [chemical binding]; other site
1198627001728	cationic pore residues; other site
1198627001729	oxalacetate/citrate binding site [chemical binding]; other site
1198627001730	coenzyme A binding site [chemical binding]; other site
1198627001731	catalytic triad [active]
1198627001732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627001733	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627001734	putative substrate translocation pore; other site
1198627001735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627001736	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627001737	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
1198627001738	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1198627001739	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1198627001740	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627001741	inhibitor-cofactor binding pocket; inhibition site
1198627001742	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627001743	catalytic residue [active]
1198627001744	Phosphotransferase enzyme family; Region: APH; pfam01636
1198627001745	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1198627001746	short chain dehydrogenase; Provisional; Region: PRK12829
1198627001747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627001748	NAD(P) binding site [chemical binding]; other site
1198627001749	active site
1198627001750	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627001751	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1198627001752	DNA-binding site [nucleotide binding]; DNA binding site
1198627001753	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1198627001754	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1198627001755	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1198627001756	HAMP domain; Region: HAMP; pfam00672
1198627001757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627001758	dimer interface [polypeptide binding]; other site
1198627001759	phosphorylation site [posttranslational modification]
1198627001760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627001761	ATP binding site [chemical binding]; other site
1198627001762	Mg2+ binding site [ion binding]; other site
1198627001763	G-X-G motif; other site
1198627001764	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627001765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627001766	active site
1198627001767	phosphorylation site [posttranslational modification]
1198627001768	intermolecular recognition site; other site
1198627001769	dimerization interface [polypeptide binding]; other site
1198627001770	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627001771	DNA binding site [nucleotide binding]
1198627001772	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627001773	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627001774	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1198627001775	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001776	substrate binding site [chemical binding]; other site
1198627001777	oxyanion hole (OAH) forming residues; other site
1198627001778	trimer interface [polypeptide binding]; other site
1198627001779	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1198627001780	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1198627001781	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
1198627001782	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1198627001783	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1198627001784	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627001785	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1198627001786	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1198627001787	hydrophobic ligand binding site; other site
1198627001788	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627001789	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1198627001790	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627001791	putative substrate translocation pore; other site
1198627001792	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1198627001793	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627001794	NAD(P) binding site [chemical binding]; other site
1198627001795	catalytic residues [active]
1198627001796	hypothetical protein; Validated; Region: PRK02101
1198627001797	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1198627001798	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1198627001799	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1198627001800	DNA polymerase IV; Validated; Region: PRK03858
1198627001801	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1198627001802	active site
1198627001803	DNA binding site [nucleotide binding]
1198627001804	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627001805	MarR family; Region: MarR; pfam01047
1198627001806	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1198627001807	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001808	substrate binding site [chemical binding]; other site
1198627001809	oxyanion hole (OAH) forming residues; other site
1198627001810	trimer interface [polypeptide binding]; other site
1198627001811	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1198627001812	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1198627001813	NAD(P) binding site [chemical binding]; other site
1198627001814	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627001815	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627001816	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627001817	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627001818	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1198627001819	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627001820	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627001821	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627001822	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1198627001823	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1198627001824	active site
1198627001825	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1198627001826	ArsC family; Region: ArsC; pfam03960
1198627001827	catalytic residues [active]
1198627001828	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627001829	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627001830	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1198627001831	dimerization interface [polypeptide binding]; other site
1198627001832	substrate binding pocket [chemical binding]; other site
1198627001833	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627001834	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627001835	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1198627001836	dimerization interface [polypeptide binding]; other site
1198627001837	formate dehydrogenase; Provisional; Region: PRK07574
1198627001838	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
1198627001839	dimerization interface [polypeptide binding]; other site
1198627001840	ligand binding site [chemical binding]; other site
1198627001841	NAD binding site [chemical binding]; other site
1198627001842	catalytic site [active]
1198627001843	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
1198627001844	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627001845	dimer interface [polypeptide binding]; other site
1198627001846	active site
1198627001847	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1198627001848	Permease; Region: Permease; pfam02405
1198627001849	Permease; Region: Permease; pfam02405
1198627001850	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1198627001851	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1198627001852	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1198627001853	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1198627001854	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1198627001855	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1198627001856	Predicted esterase [General function prediction only]; Region: COG0627
1198627001857	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
1198627001858	cyanate hydratase; Validated; Region: PRK02866
1198627001859	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
1198627001860	oligomer interface [polypeptide binding]; other site
1198627001861	active site
1198627001862	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1198627001863	MarR family; Region: MarR; pfam01047
1198627001864	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1198627001865	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1198627001866	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1198627001867	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1198627001868	putative DNA binding site [nucleotide binding]; other site
1198627001869	putative homodimer interface [polypeptide binding]; other site
1198627001870	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
1198627001871	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
1198627001872	nucleotide binding site [chemical binding]; other site
1198627001873	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1198627001874	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1198627001875	active site
1198627001876	DNA binding site [nucleotide binding]
1198627001877	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1198627001878	DNA binding site [nucleotide binding]
1198627001879	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1198627001880	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1198627001881	active site
1198627001882	SAM binding site [chemical binding]; other site
1198627001883	homodimer interface [polypeptide binding]; other site
1198627001884	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1198627001885	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
1198627001886	putative DNA binding site [nucleotide binding]; other site
1198627001887	catalytic residue [active]
1198627001888	putative H2TH interface [polypeptide binding]; other site
1198627001889	putative catalytic residues [active]
1198627001890	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1198627001891	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1198627001892	short chain dehydrogenase; Provisional; Region: PRK08251
1198627001893	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627001894	NAD(P) binding site [chemical binding]; other site
1198627001895	active site
1198627001896	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1198627001897	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1198627001898	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1198627001899	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1198627001900	D-pathway; other site
1198627001901	Putative ubiquinol binding site [chemical binding]; other site
1198627001902	Low-spin heme (heme b) binding site [chemical binding]; other site
1198627001903	Putative water exit pathway; other site
1198627001904	Binuclear center (heme o3/CuB) [ion binding]; other site
1198627001905	K-pathway; other site
1198627001906	Putative proton exit pathway; other site
1198627001907	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1198627001908	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1198627001909	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1198627001910	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1198627001911	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1198627001912	inhibitor site; inhibition site
1198627001913	active site
1198627001914	dimer interface [polypeptide binding]; other site
1198627001915	catalytic residue [active]
1198627001916	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
1198627001917	intersubunit interface [polypeptide binding]; other site
1198627001918	active site
1198627001919	Zn2+ binding site [ion binding]; other site
1198627001920	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1198627001921	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1198627001922	active site
1198627001923	dimer interface [polypeptide binding]; other site
1198627001924	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1198627001925	dimer interface [polypeptide binding]; other site
1198627001926	active site
1198627001927	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1198627001928	Part of AAA domain; Region: AAA_19; pfam13245
1198627001929	Family description; Region: UvrD_C_2; pfam13538
1198627001930	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1198627001931	Peptidase family M23; Region: Peptidase_M23; pfam01551
1198627001932	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1198627001933	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1198627001934	CoA-ligase; Region: Ligase_CoA; pfam00549
1198627001935	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1198627001936	CoA binding domain; Region: CoA_binding; smart00881
1198627001937	CoA-ligase; Region: Ligase_CoA; pfam00549
1198627001938	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1198627001939	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627001940	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1198627001941	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1198627001942	active site
1198627001943	dimer interface [polypeptide binding]; other site
1198627001944	non-prolyl cis peptide bond; other site
1198627001945	insertion regions; other site
1198627001946	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1198627001947	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1198627001948	active site
1198627001949	substrate binding site [chemical binding]; other site
1198627001950	cosubstrate binding site; other site
1198627001951	catalytic site [active]
1198627001952	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1198627001953	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1198627001954	purine monophosphate binding site [chemical binding]; other site
1198627001955	dimer interface [polypeptide binding]; other site
1198627001956	putative catalytic residues [active]
1198627001957	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1198627001958	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1198627001959	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1198627001960	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1198627001961	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1198627001962	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1198627001963	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1198627001964	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627001965	trimer interface [polypeptide binding]; other site
1198627001966	oxyanion hole (OAH) forming residues; other site
1198627001967	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001968	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1198627001969	active site
1198627001970	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1198627001971	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1198627001972	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1198627001973	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1198627001974	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1198627001975	carboxyltransferase (CT) interaction site; other site
1198627001976	biotinylation site [posttranslational modification]; other site
1198627001977	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1198627001978	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1198627001979	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627001980	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627001981	active site
1198627001982	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627001983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627001984	active site
1198627001985	phosphorylation site [posttranslational modification]
1198627001986	intermolecular recognition site; other site
1198627001987	dimerization interface [polypeptide binding]; other site
1198627001988	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627001989	DNA binding site [nucleotide binding]
1198627001990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1198627001991	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1198627001992	dimerization interface [polypeptide binding]; other site
1198627001993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627001994	dimer interface [polypeptide binding]; other site
1198627001995	phosphorylation site [posttranslational modification]
1198627001996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627001997	ATP binding site [chemical binding]; other site
1198627001998	Mg2+ binding site [ion binding]; other site
1198627001999	G-X-G motif; other site
1198627002000	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1198627002001	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1198627002002	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1198627002003	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1198627002004	MPT binding site; other site
1198627002005	trimer interface [polypeptide binding]; other site
1198627002006	MspA; Region: MspA; pfam09203
1198627002007	MspA; Region: MspA; pfam09203
1198627002008	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1198627002009	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1198627002010	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
1198627002011	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1198627002012	active site
1198627002013	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1198627002014	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1198627002015	dimer interface [polypeptide binding]; other site
1198627002016	putative functional site; other site
1198627002017	putative MPT binding site; other site
1198627002018	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1198627002019	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1198627002020	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1198627002021	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
1198627002022	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627002023	catalytic residue [active]
1198627002024	Cupin domain; Region: Cupin_2; pfam07883
1198627002025	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1198627002026	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627002027	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1198627002028	NAD(P) binding site [chemical binding]; other site
1198627002029	arginine deiminase; Provisional; Region: PRK01388
1198627002030	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1198627002031	Predicted methyltransferases [General function prediction only]; Region: COG0313
1198627002032	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1198627002033	putative SAM binding site [chemical binding]; other site
1198627002034	putative homodimer interface [polypeptide binding]; other site
1198627002035	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
1198627002036	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1198627002037	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1198627002038	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627002039	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627002040	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1198627002041	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1198627002042	active site
1198627002043	HIGH motif; other site
1198627002044	KMSKS motif; other site
1198627002045	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1198627002046	tRNA binding surface [nucleotide binding]; other site
1198627002047	anticodon binding site; other site
1198627002048	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1198627002049	active site
1198627002050	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1198627002051	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1198627002052	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1198627002053	G5 domain; Region: G5; pfam07501
1198627002054	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1198627002055	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1198627002056	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1198627002057	L-asparagine permease; Provisional; Region: PRK15049
1198627002058	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1198627002059	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1198627002060	active site
1198627002061	ATP binding site [chemical binding]; other site
1198627002062	substrate binding site [chemical binding]; other site
1198627002063	activation loop (A-loop); other site
1198627002064	Transport protein; Region: actII; TIGR00833
1198627002065	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627002066	Transport protein; Region: actII; TIGR00833
1198627002067	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1198627002068	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1198627002069	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1198627002070	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
1198627002071	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627002072	acyl-activating enzyme (AAE) consensus motif; other site
1198627002073	active site
1198627002074	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1198627002075	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1198627002076	dimer interface [polypeptide binding]; other site
1198627002077	active site
1198627002078	CoA binding pocket [chemical binding]; other site
1198627002079	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1198627002080	putative active site [active]
1198627002081	catalytic residue [active]
1198627002082	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1198627002083	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1198627002084	5S rRNA interface [nucleotide binding]; other site
1198627002085	CTC domain interface [polypeptide binding]; other site
1198627002086	L16 interface [polypeptide binding]; other site
1198627002087	short chain dehydrogenase; Provisional; Region: PRK06197
1198627002088	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1198627002089	putative NAD(P) binding site [chemical binding]; other site
1198627002090	active site
1198627002091	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1198627002092	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1198627002093	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1198627002094	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627002095	active site
1198627002096	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1198627002097	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1198627002098	Substrate binding site; other site
1198627002099	Mg++ binding site; other site
1198627002100	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1198627002101	active site
1198627002102	substrate binding site [chemical binding]; other site
1198627002103	CoA binding site [chemical binding]; other site
1198627002104	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1198627002105	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1198627002106	active site
1198627002107	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1198627002108	substrate binding site [chemical binding]; other site
1198627002109	catalytic residues [active]
1198627002110	dimer interface [polypeptide binding]; other site
1198627002111	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1198627002112	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1198627002113	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1198627002114	ATP binding site [chemical binding]; other site
1198627002115	putative Mg++ binding site [ion binding]; other site
1198627002116	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1198627002117	nucleotide binding region [chemical binding]; other site
1198627002118	ATP-binding site [chemical binding]; other site
1198627002119	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1198627002120	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
1198627002121	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1198627002122	homodimer interface [polypeptide binding]; other site
1198627002123	metal binding site [ion binding]; metal-binding site
1198627002124	Iron permease FTR1 family; Region: FTR1; cl00475
1198627002125	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
1198627002126	Imelysin; Region: Peptidase_M75; cl09159
1198627002127	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1198627002128	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1198627002129	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1198627002130	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1198627002131	Imelysin; Region: Peptidase_M75; pfam09375
1198627002132	enolase; Provisional; Region: eno; PRK00077
1198627002133	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1198627002134	dimer interface [polypeptide binding]; other site
1198627002135	metal binding site [ion binding]; metal-binding site
1198627002136	substrate binding pocket [chemical binding]; other site
1198627002137	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1198627002138	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1198627002139	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1198627002140	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1198627002141	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627002142	acyl-activating enzyme (AAE) consensus motif; other site
1198627002143	active site
1198627002144	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
1198627002145	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1198627002146	LGFP repeat; Region: LGFP; pfam08310
1198627002147	enoyl-CoA hydratase; Provisional; Region: PRK05862
1198627002148	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627002149	substrate binding site [chemical binding]; other site
1198627002150	oxyanion hole (OAH) forming residues; other site
1198627002151	trimer interface [polypeptide binding]; other site
1198627002152	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1198627002153	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1198627002154	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1198627002155	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627002156	substrate binding site [chemical binding]; other site
1198627002157	oxyanion hole (OAH) forming residues; other site
1198627002158	trimer interface [polypeptide binding]; other site
1198627002159	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1198627002160	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627002161	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
1198627002162	substrate binding pocket [chemical binding]; other site
1198627002163	FAD binding site [chemical binding]; other site
1198627002164	catalytic base [active]
1198627002165	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1198627002166	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1198627002167	tetrameric interface [polypeptide binding]; other site
1198627002168	NAD binding site [chemical binding]; other site
1198627002169	catalytic residues [active]
1198627002170	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1198627002171	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627002172	ATP-grasp domain; Region: ATP-grasp; pfam02222
1198627002173	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
1198627002174	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627002175	dimer interface [polypeptide binding]; other site
1198627002176	active site
1198627002177	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1198627002178	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627002179	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1198627002180	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1198627002181	dimer interface [polypeptide binding]; other site
1198627002182	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627002183	catalytic residue [active]
1198627002184	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1198627002185	RDD family; Region: RDD; pfam06271
1198627002186	cystathionine gamma-synthase; Provisional; Region: PRK07811
1198627002187	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1198627002188	homodimer interface [polypeptide binding]; other site
1198627002189	substrate-cofactor binding pocket; other site
1198627002190	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627002191	catalytic residue [active]
1198627002192	threonine dehydratase; Provisional; Region: PRK08198
1198627002193	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1198627002194	tetramer interface [polypeptide binding]; other site
1198627002195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627002196	catalytic residue [active]
1198627002197	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1198627002198	putative active site [active]
1198627002199	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1198627002200	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1198627002201	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1198627002202	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1198627002203	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1198627002204	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1198627002205	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1198627002206	catalytic residues [active]
1198627002207	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1198627002208	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1198627002209	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1198627002210	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1198627002211	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1198627002212	catalytic residue [active]
1198627002213	putative FPP diphosphate  binding site; other site
1198627002214	putative FPP binding hydrophobic cleft; other site
1198627002215	dimer interface [polypeptide binding]; other site
1198627002216	putative IPP diphosphate binding site; other site
1198627002217	classical (c) SDRs; Region: SDR_c; cd05233
1198627002218	short chain dehydrogenase; Provisional; Region: PRK12939
1198627002219	NAD(P) binding site [chemical binding]; other site
1198627002220	active site
1198627002221	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627002222	Cytochrome P450; Region: p450; cl12078
1198627002223	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627002224	Cytochrome P450; Region: p450; cl12078
1198627002225	short chain dehydrogenase; Provisional; Region: PRK07775
1198627002226	classical (c) SDRs; Region: SDR_c; cd05233
1198627002227	NAD(P) binding site [chemical binding]; other site
1198627002228	active site
1198627002229	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627002230	Cytochrome P450; Region: p450; cl12078
1198627002231	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627002232	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627002233	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
1198627002234	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
1198627002235	NAD binding site [chemical binding]; other site
1198627002236	catalytic residues [active]
1198627002237	short chain dehydrogenase; Provisional; Region: PRK07774
1198627002238	classical (c) SDRs; Region: SDR_c; cd05233
1198627002239	NAD(P) binding site [chemical binding]; other site
1198627002240	active site
1198627002241	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1198627002242	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1198627002243	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1198627002244	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627002245	substrate binding pocket [chemical binding]; other site
1198627002246	catalytic triad [active]
1198627002247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627002248	putative PBP binding loops; other site
1198627002249	dimer interface [polypeptide binding]; other site
1198627002250	ABC-ATPase subunit interface; other site
1198627002251	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1198627002252	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1198627002253	Walker A/P-loop; other site
1198627002254	ATP binding site [chemical binding]; other site
1198627002255	Q-loop/lid; other site
1198627002256	ABC transporter signature motif; other site
1198627002257	Walker B; other site
1198627002258	D-loop; other site
1198627002259	H-loop/switch region; other site
1198627002260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627002261	ABC-ATPase subunit interface; other site
1198627002262	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1198627002263	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1198627002264	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1198627002265	pantothenate kinase; Provisional; Region: PRK05439
1198627002266	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1198627002267	ATP-binding site [chemical binding]; other site
1198627002268	CoA-binding site [chemical binding]; other site
1198627002269	Mg2+-binding site [ion binding]; other site
1198627002270	serine hydroxymethyltransferase; Provisional; Region: PRK13580
1198627002271	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1198627002272	dimer interface [polypeptide binding]; other site
1198627002273	active site
1198627002274	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1198627002275	folate binding site [chemical binding]; other site
1198627002276	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1198627002277	dinuclear metal binding motif [ion binding]; other site
1198627002278	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1198627002279	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1198627002280	putative active site [active]
1198627002281	PhoH-like protein; Region: PhoH; pfam02562
1198627002282	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1198627002283	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1198627002284	NodB motif; other site
1198627002285	active site
1198627002286	catalytic site [active]
1198627002287	metal binding site [ion binding]; metal-binding site
1198627002288	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1198627002289	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627002290	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627002291	DNA binding residues [nucleotide binding]
1198627002292	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1198627002293	Class II fumarases; Region: Fumarase_classII; cd01362
1198627002294	active site
1198627002295	tetramer interface [polypeptide binding]; other site
1198627002296	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1198627002297	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1198627002298	putative active site [active]
1198627002299	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
1198627002300	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1198627002301	active site
1198627002302	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1198627002303	dimer interface [polypeptide binding]; other site
1198627002304	substrate binding site [chemical binding]; other site
1198627002305	catalytic residue [active]
1198627002306	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1198627002307	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1198627002308	generic binding surface II; other site
1198627002309	generic binding surface I; other site
1198627002310	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1198627002311	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1198627002312	carbon starvation protein A; Provisional; Region: PRK15015
1198627002313	Carbon starvation protein CstA; Region: CstA; pfam02554
1198627002314	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1198627002315	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1198627002316	GTP-binding protein YchF; Reviewed; Region: PRK09601
1198627002317	YchF GTPase; Region: YchF; cd01900
1198627002318	G1 box; other site
1198627002319	GTP/Mg2+ binding site [chemical binding]; other site
1198627002320	Switch I region; other site
1198627002321	G2 box; other site
1198627002322	Switch II region; other site
1198627002323	G3 box; other site
1198627002324	G4 box; other site
1198627002325	G5 box; other site
1198627002326	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1198627002327	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1198627002328	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1198627002329	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1198627002330	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1198627002331	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1198627002332	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1198627002333	dimer interface [polypeptide binding]; other site
1198627002334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627002335	catalytic residue [active]
1198627002336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627002337	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627002338	putative substrate translocation pore; other site
1198627002339	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1198627002340	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627002341	ABC transporter; Region: ABC_tran_2; pfam12848
1198627002342	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627002343	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1198627002344	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1198627002345	dimer interface [polypeptide binding]; other site
1198627002346	catalytic triad [active]
1198627002347	peroxidatic and resolving cysteines [active]
1198627002348	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627002349	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1198627002350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627002351	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1198627002352	S-adenosylmethionine binding site [chemical binding]; other site
1198627002353	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627002354	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1198627002355	mannosyltransferase; Provisional; Region: pimE; PRK13375
1198627002356	short chain dehydrogenase; Validated; Region: PRK06182
1198627002357	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1198627002358	NADP binding site [chemical binding]; other site
1198627002359	active site
1198627002360	steroid binding site; other site
1198627002361	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1198627002362	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1198627002363	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1198627002364	putative active site [active]
1198627002365	putative substrate binding site [chemical binding]; other site
1198627002366	putative cosubstrate binding site; other site
1198627002367	catalytic site [active]
1198627002368	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1198627002369	active site
1198627002370	8-oxo-dGMP binding site [chemical binding]; other site
1198627002371	nudix motif; other site
1198627002372	metal binding site [ion binding]; metal-binding site
1198627002373	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1198627002374	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1198627002375	G1 box; other site
1198627002376	putative GEF interaction site [polypeptide binding]; other site
1198627002377	GTP/Mg2+ binding site [chemical binding]; other site
1198627002378	Switch I region; other site
1198627002379	G2 box; other site
1198627002380	G3 box; other site
1198627002381	Switch II region; other site
1198627002382	G4 box; other site
1198627002383	G5 box; other site
1198627002384	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1198627002385	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1198627002386	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1198627002387	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1198627002388	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1198627002389	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1198627002390	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
1198627002391	FO synthase; Reviewed; Region: fbiC; PRK09234
1198627002392	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627002393	FeS/SAM binding site; other site
1198627002394	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627002395	FeS/SAM binding site; other site
1198627002396	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1198627002397	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1198627002398	active site
1198627002399	FMN binding site [chemical binding]; other site
1198627002400	2,4-decadienoyl-CoA binding site; other site
1198627002401	catalytic residue [active]
1198627002402	4Fe-4S cluster binding site [ion binding]; other site
1198627002403	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1198627002404	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627002405	Predicted transcriptional regulators [Transcription]; Region: COG1695
1198627002406	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1198627002407	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1198627002408	Ferredoxin [Energy production and conversion]; Region: COG1146
1198627002409	4Fe-4S binding domain; Region: Fer4; pfam00037
1198627002410	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1198627002411	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627002412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627002413	homodimer interface [polypeptide binding]; other site
1198627002414	catalytic residue [active]
1198627002415	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1198627002416	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1198627002417	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
1198627002418	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
1198627002419	Glutamate binding site [chemical binding]; other site
1198627002420	NAD binding site [chemical binding]; other site
1198627002421	catalytic residues [active]
1198627002422	Proline dehydrogenase; Region: Pro_dh; cl03282
1198627002423	acyl-CoA synthetase; Validated; Region: PRK07787
1198627002424	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627002425	acyl-activating enzyme (AAE) consensus motif; other site
1198627002426	AMP binding site [chemical binding]; other site
1198627002427	active site
1198627002428	CoA binding site [chemical binding]; other site
1198627002429	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
1198627002430	active site
1198627002431	catalytic triad [active]
1198627002432	oxyanion hole [active]
1198627002433	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1198627002434	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1198627002435	putative trimer interface [polypeptide binding]; other site
1198627002436	putative CoA binding site [chemical binding]; other site
1198627002437	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1198627002438	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1198627002439	metal binding site [ion binding]; metal-binding site
1198627002440	putative dimer interface [polypeptide binding]; other site
1198627002441	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1198627002442	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1198627002443	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627002444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627002445	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
1198627002446	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627002447	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1198627002448	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
1198627002449	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
1198627002450	acyl-activating enzyme (AAE) consensus motif; other site
1198627002451	putative AMP binding site [chemical binding]; other site
1198627002452	putative active site [active]
1198627002453	putative CoA binding site [chemical binding]; other site
1198627002454	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1198627002455	extended (e) SDRs; Region: SDR_e; cd08946
1198627002456	NAD(P) binding site [chemical binding]; other site
1198627002457	active site
1198627002458	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1198627002459	dihydropteroate synthase; Region: DHPS; TIGR01496
1198627002460	substrate binding pocket [chemical binding]; other site
1198627002461	dimer interface [polypeptide binding]; other site
1198627002462	inhibitor binding site; inhibition site
1198627002463	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1198627002464	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1198627002465	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1198627002466	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1198627002467	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1198627002468	ligand binding site; other site
1198627002469	oligomer interface; other site
1198627002470	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1198627002471	dimer interface [polypeptide binding]; other site
1198627002472	N-terminal domain interface [polypeptide binding]; other site
1198627002473	sulfate 1 binding site; other site
1198627002474	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1198627002475	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627002476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627002477	homodimer interface [polypeptide binding]; other site
1198627002478	catalytic residue [active]
1198627002479	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1198627002480	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1198627002481	Walker A/P-loop; other site
1198627002482	ATP binding site [chemical binding]; other site
1198627002483	Q-loop/lid; other site
1198627002484	ABC transporter signature motif; other site
1198627002485	Walker B; other site
1198627002486	D-loop; other site
1198627002487	H-loop/switch region; other site
1198627002488	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1198627002489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627002490	S-adenosylmethionine binding site [chemical binding]; other site
1198627002491	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1198627002492	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627002493	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627002494	DNA binding residues [nucleotide binding]
1198627002495	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1198627002496	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1198627002497	protein binding site [polypeptide binding]; other site
1198627002498	sec-independent translocase; Provisional; Region: PRK03100
1198627002499	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1198627002500	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1198627002501	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1198627002502	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1198627002503	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1198627002504	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1198627002505	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1198627002506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627002507	dimer interface [polypeptide binding]; other site
1198627002508	conserved gate region; other site
1198627002509	putative PBP binding loops; other site
1198627002510	ABC-ATPase subunit interface; other site
1198627002511	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1198627002512	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1198627002513	Walker A/P-loop; other site
1198627002514	ATP binding site [chemical binding]; other site
1198627002515	Q-loop/lid; other site
1198627002516	ABC transporter signature motif; other site
1198627002517	Walker B; other site
1198627002518	D-loop; other site
1198627002519	H-loop/switch region; other site
1198627002520	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1198627002521	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1198627002522	oligomer interface [polypeptide binding]; other site
1198627002523	metal binding site [ion binding]; metal-binding site
1198627002524	metal binding site [ion binding]; metal-binding site
1198627002525	putative Cl binding site [ion binding]; other site
1198627002526	basic sphincter; other site
1198627002527	hydrophobic gate; other site
1198627002528	periplasmic entrance; other site
1198627002529	short chain dehydrogenase; Provisional; Region: PRK07825
1198627002530	classical (c) SDRs; Region: SDR_c; cd05233
1198627002531	NAD(P) binding site [chemical binding]; other site
1198627002532	active site
1198627002533	short chain dehydrogenase; Provisional; Region: PRK07832
1198627002534	classical (c) SDRs; Region: SDR_c; cd05233
1198627002535	NAD(P) binding site [chemical binding]; other site
1198627002536	active site
1198627002537	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1198627002538	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1198627002539	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1198627002540	NAD(P) binding pocket [chemical binding]; other site
1198627002541	hypothetical protein; Provisional; Region: PRK06194
1198627002542	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627002543	NAD(P) binding site [chemical binding]; other site
1198627002544	active site
1198627002545	classical (c) SDRs; Region: SDR_c; cd05233
1198627002546	short chain dehydrogenase; Provisional; Region: PRK05650
1198627002547	NAD(P) binding site [chemical binding]; other site
1198627002548	active site
1198627002549	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1198627002550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627002551	S-adenosylmethionine binding site [chemical binding]; other site
1198627002552	Secretory lipase; Region: LIP; pfam03583
1198627002553	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1198627002554	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1198627002555	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1198627002556	TPP-binding site [chemical binding]; other site
1198627002557	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1198627002558	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1198627002559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627002560	putative substrate translocation pore; other site
1198627002561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627002562	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627002563	putative substrate translocation pore; other site
1198627002564	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1198627002565	FAD binding domain; Region: FAD_binding_4; pfam01565
1198627002566	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627002567	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
1198627002568	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1198627002569	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
1198627002570	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1198627002571	ATP binding site [chemical binding]; other site
1198627002572	Mg++ binding site [ion binding]; other site
1198627002573	motif III; other site
1198627002574	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1198627002575	nucleotide binding region [chemical binding]; other site
1198627002576	ATP-binding site [chemical binding]; other site
1198627002577	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1198627002578	putative RNA binding site [nucleotide binding]; other site
1198627002579	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627002580	Cytochrome P450; Region: p450; cl12078
1198627002581	FAD binding domain; Region: FAD_binding_4; pfam01565
1198627002582	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1198627002583	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1198627002584	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627002585	NAD(P) binding site [chemical binding]; other site
1198627002586	active site
1198627002587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627002588	H+ Antiporter protein; Region: 2A0121; TIGR00900
1198627002589	putative substrate translocation pore; other site
1198627002590	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1198627002591	HIT family signature motif; other site
1198627002592	catalytic residue [active]
1198627002593	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1198627002594	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1198627002595	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1198627002596	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1198627002597	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1198627002598	Walker A/P-loop; other site
1198627002599	ATP binding site [chemical binding]; other site
1198627002600	Q-loop/lid; other site
1198627002601	ABC transporter signature motif; other site
1198627002602	Walker B; other site
1198627002603	D-loop; other site
1198627002604	H-loop/switch region; other site
1198627002605	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1198627002606	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1198627002607	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627002608	Walker A/P-loop; other site
1198627002609	ATP binding site [chemical binding]; other site
1198627002610	Q-loop/lid; other site
1198627002611	ABC transporter signature motif; other site
1198627002612	Walker B; other site
1198627002613	D-loop; other site
1198627002614	H-loop/switch region; other site
1198627002615	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1198627002616	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1198627002617	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627002618	catalytic core [active]
1198627002619	AAA ATPase domain; Region: AAA_15; pfam13175
1198627002620	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1198627002621	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1198627002622	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627002623	active site
1198627002624	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1198627002625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627002626	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627002627	Cytochrome P450; Region: p450; cl12078
1198627002628	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627002629	Cytochrome P450; Region: p450; cl12078
1198627002630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627002631	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627002632	putative substrate translocation pore; other site
1198627002633	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1198627002634	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627002635	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1198627002636	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1198627002637	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
1198627002638	hypothetical protein; Provisional; Region: PRK07236
1198627002639	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1198627002640	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1198627002641	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1198627002642	active site
1198627002643	HIGH motif; other site
1198627002644	KMSK motif region; other site
1198627002645	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1198627002646	tRNA binding surface [nucleotide binding]; other site
1198627002647	anticodon binding site; other site
1198627002648	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1198627002649	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1198627002650	active site
1198627002651	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1198627002652	substrate binding site [chemical binding]; other site
1198627002653	catalytic residues [active]
1198627002654	dimer interface [polypeptide binding]; other site
1198627002655	homoserine dehydrogenase; Provisional; Region: PRK06349
1198627002656	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1198627002657	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1198627002658	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1198627002659	threonine synthase; Reviewed; Region: PRK06721
1198627002660	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1198627002661	homodimer interface [polypeptide binding]; other site
1198627002662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627002663	catalytic residue [active]
1198627002664	homoserine kinase; Provisional; Region: PRK01212
1198627002665	transcription termination factor Rho; Provisional; Region: PRK12608
1198627002666	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1198627002667	RNA binding site [nucleotide binding]; other site
1198627002668	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1198627002669	multimer interface [polypeptide binding]; other site
1198627002670	Walker A motif; other site
1198627002671	ATP binding site [chemical binding]; other site
1198627002672	Walker B motif; other site
1198627002673	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1198627002674	PCRF domain; Region: PCRF; pfam03462
1198627002675	RF-1 domain; Region: RF-1; pfam00472
1198627002676	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1198627002677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627002678	S-adenosylmethionine binding site [chemical binding]; other site
1198627002679	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1198627002680	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1198627002681	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1198627002682	Mg++ binding site [ion binding]; other site
1198627002683	putative catalytic motif [active]
1198627002684	substrate binding site [chemical binding]; other site
1198627002685	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1198627002686	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1198627002687	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1198627002688	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1198627002689	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
1198627002690	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1198627002691	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
1198627002692	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1198627002693	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1198627002694	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1198627002695	beta subunit interaction interface [polypeptide binding]; other site
1198627002696	Walker A motif; other site
1198627002697	ATP binding site [chemical binding]; other site
1198627002698	Walker B motif; other site
1198627002699	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1198627002700	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1198627002701	core domain interface [polypeptide binding]; other site
1198627002702	delta subunit interface [polypeptide binding]; other site
1198627002703	epsilon subunit interface [polypeptide binding]; other site
1198627002704	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1198627002705	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1198627002706	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1198627002707	alpha subunit interaction interface [polypeptide binding]; other site
1198627002708	Walker A motif; other site
1198627002709	ATP binding site [chemical binding]; other site
1198627002710	Walker B motif; other site
1198627002711	inhibitor binding site; inhibition site
1198627002712	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1198627002713	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1198627002714	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1198627002715	gamma subunit interface [polypeptide binding]; other site
1198627002716	epsilon subunit interface [polypeptide binding]; other site
1198627002717	LBP interface [polypeptide binding]; other site
1198627002718	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1198627002719	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1198627002720	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1198627002721	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1198627002722	hinge; other site
1198627002723	active site
1198627002724	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1198627002725	dimerization interface [polypeptide binding]; other site
1198627002726	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1198627002727	cyclase homology domain; Region: CHD; cd07302
1198627002728	nucleotidyl binding site; other site
1198627002729	metal binding site [ion binding]; metal-binding site
1198627002730	dimer interface [polypeptide binding]; other site
1198627002731	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
1198627002732	hypothetical protein; Provisional; Region: PRK03298
1198627002733	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1198627002734	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1198627002735	dimer interface [polypeptide binding]; other site
1198627002736	substrate binding site [chemical binding]; other site
1198627002737	metal binding site [ion binding]; metal-binding site
1198627002738	putative acyltransferase; Provisional; Region: PRK05790
1198627002739	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627002740	dimer interface [polypeptide binding]; other site
1198627002741	active site
1198627002742	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1198627002743	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1198627002744	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1198627002745	glycogen branching enzyme; Provisional; Region: PRK05402
1198627002746	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1198627002747	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1198627002748	active site
1198627002749	catalytic site [active]
1198627002750	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1198627002751	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1198627002752	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1198627002753	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1198627002754	active site
1198627002755	homodimer interface [polypeptide binding]; other site
1198627002756	catalytic site [active]
1198627002757	acceptor binding site [chemical binding]; other site
1198627002758	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1198627002759	putative homodimer interface [polypeptide binding]; other site
1198627002760	putative active site pocket [active]
1198627002761	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1198627002762	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1198627002763	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1198627002764	ATP binding site [chemical binding]; other site
1198627002765	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1198627002766	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1198627002767	Isochorismatase family; Region: Isochorismatase; pfam00857
1198627002768	catalytic triad [active]
1198627002769	metal binding site [ion binding]; metal-binding site
1198627002770	conserved cis-peptide bond; other site
1198627002771	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1198627002772	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1198627002773	active site
1198627002774	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1198627002775	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1198627002776	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1198627002777	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1198627002778	cleavage site
1198627002779	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
1198627002780	MPN+ (JAMM) motif; other site
1198627002781	Zinc-binding site [ion binding]; other site
1198627002782	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1198627002783	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1198627002784	dimer interface [polypeptide binding]; other site
1198627002785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627002786	catalytic residue [active]
1198627002787	Rhomboid family; Region: Rhomboid; pfam01694
1198627002788	glutamate racemase; Provisional; Region: PRK00865
1198627002789	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1198627002790	ribonuclease PH; Reviewed; Region: rph; PRK00173
1198627002791	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1198627002792	hexamer interface [polypeptide binding]; other site
1198627002793	active site
1198627002794	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1198627002795	active site
1198627002796	dimerization interface [polypeptide binding]; other site
1198627002797	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1198627002798	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1198627002799	putative NAD(P) binding site [chemical binding]; other site
1198627002800	Glucitol operon activator protein (GutM); Region: GutM; cl01890
1198627002801	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
1198627002802	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627002803	acyl-activating enzyme (AAE) consensus motif; other site
1198627002804	active site
1198627002805	enoyl-CoA hydratase; Provisional; Region: PRK06563
1198627002806	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627002807	substrate binding site [chemical binding]; other site
1198627002808	oxyanion hole (OAH) forming residues; other site
1198627002809	trimer interface [polypeptide binding]; other site
1198627002810	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627002811	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627002812	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1198627002813	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1198627002814	molybdopterin cofactor binding site; other site
1198627002815	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1198627002816	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
1198627002817	putative molybdopterin cofactor binding site; other site
1198627002818	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1198627002819	hypothetical protein; Provisional; Region: PRK06184
1198627002820	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627002821	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627002822	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1198627002823	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627002824	DNA-binding site [nucleotide binding]; DNA binding site
1198627002825	UTRA domain; Region: UTRA; pfam07702
1198627002826	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
1198627002827	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627002828	motif II; other site
1198627002829	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1198627002830	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1198627002831	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1198627002832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627002833	Walker A/P-loop; other site
1198627002834	ATP binding site [chemical binding]; other site
1198627002835	Q-loop/lid; other site
1198627002836	ABC transporter signature motif; other site
1198627002837	Walker B; other site
1198627002838	D-loop; other site
1198627002839	H-loop/switch region; other site
1198627002840	TOBE domain; Region: TOBE_2; pfam08402
1198627002841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627002842	dimer interface [polypeptide binding]; other site
1198627002843	ABC-ATPase subunit interface; other site
1198627002844	putative PBP binding loops; other site
1198627002845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627002846	dimer interface [polypeptide binding]; other site
1198627002847	conserved gate region; other site
1198627002848	putative PBP binding loops; other site
1198627002849	ABC-ATPase subunit interface; other site
1198627002850	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1198627002851	putative active site [active]
1198627002852	putative catalytic site [active]
1198627002853	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1198627002854	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627002855	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1198627002856	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1198627002857	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1198627002858	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
1198627002859	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1198627002860	phosphate binding site [ion binding]; other site
1198627002861	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
1198627002862	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
1198627002863	putative active site [active]
1198627002864	putative catalytic site [active]
1198627002865	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1198627002866	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1198627002867	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
1198627002868	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
1198627002869	putative NAD(P) binding site [chemical binding]; other site
1198627002870	active site
1198627002871	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1198627002872	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1198627002873	active site
1198627002874	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1198627002875	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1198627002876	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1198627002877	catalytic triad [active]
1198627002878	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627002879	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1198627002880	Transport protein; Region: actII; TIGR00833
1198627002881	Histidine kinase; Region: HisKA_3; pfam07730
1198627002882	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1198627002883	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1198627002884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627002885	active site
1198627002886	phosphorylation site [posttranslational modification]
1198627002887	intermolecular recognition site; other site
1198627002888	dimerization interface [polypeptide binding]; other site
1198627002889	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1198627002890	DNA binding residues [nucleotide binding]
1198627002891	dimerization interface [polypeptide binding]; other site
1198627002892	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1198627002893	MgtE intracellular N domain; Region: MgtE_N; smart00924
1198627002894	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1198627002895	short chain dehydrogenase; Provisional; Region: PRK07825
1198627002896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627002897	NAD(P) binding site [chemical binding]; other site
1198627002898	active site
1198627002899	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627002900	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627002901	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627002902	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1198627002903	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1198627002904	active site
1198627002905	catalytic tetrad [active]
1198627002906	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1198627002907	active site
1198627002908	catalytic site [active]
1198627002909	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
1198627002910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1198627002911	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1198627002912	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1198627002913	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1198627002914	catalytic site [active]
1198627002915	putative active site [active]
1198627002916	putative substrate binding site [chemical binding]; other site
1198627002917	dimer interface [polypeptide binding]; other site
1198627002918	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1198627002919	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1198627002920	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1198627002921	classical (c) SDRs; Region: SDR_c; cd05233
1198627002922	NAD(P) binding site [chemical binding]; other site
1198627002923	active site
1198627002924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627002925	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1198627002926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627002927	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1198627002928	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1198627002929	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1198627002930	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1198627002931	catalytic site [active]
1198627002932	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1198627002933	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1198627002934	CysD dimerization site [polypeptide binding]; other site
1198627002935	G1 box; other site
1198627002936	putative GEF interaction site [polypeptide binding]; other site
1198627002937	GTP/Mg2+ binding site [chemical binding]; other site
1198627002938	Switch I region; other site
1198627002939	G2 box; other site
1198627002940	G3 box; other site
1198627002941	Switch II region; other site
1198627002942	G4 box; other site
1198627002943	G5 box; other site
1198627002944	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1198627002945	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1198627002946	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1198627002947	ligand-binding site [chemical binding]; other site
1198627002948	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1198627002949	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1198627002950	Active Sites [active]
1198627002951	Copper resistance protein D; Region: CopD; pfam05425
1198627002952	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1198627002953	allophanate hydrolase; Provisional; Region: PRK08186
1198627002954	Amidase; Region: Amidase; cl11426
1198627002955	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1198627002956	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1198627002957	dimer interface [polypeptide binding]; other site
1198627002958	ssDNA binding site [nucleotide binding]; other site
1198627002959	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1198627002960	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1198627002961	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627002962	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627002963	ABC transporter; Region: ABC_tran_2; pfam12848
1198627002964	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627002965	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1198627002966	Pirin-related protein [General function prediction only]; Region: COG1741
1198627002967	Pirin; Region: Pirin; pfam02678
1198627002968	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
1198627002969	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1198627002970	active site
1198627002971	catalytic site [active]
1198627002972	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1198627002973	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1198627002974	apolar tunnel; other site
1198627002975	heme binding site [chemical binding]; other site
1198627002976	dimerization interface [polypeptide binding]; other site
1198627002977	Repair protein; Region: Repair_PSII; cl01535
1198627002978	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1198627002979	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1198627002980	Zn binding site [ion binding]; other site
1198627002981	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1198627002982	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1198627002983	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1198627002984	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1198627002985	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1198627002986	putative DNA binding site [nucleotide binding]; other site
1198627002987	catalytic residue [active]
1198627002988	putative H2TH interface [polypeptide binding]; other site
1198627002989	putative catalytic residues [active]
1198627002990	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1198627002991	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1198627002992	Predicted esterase [General function prediction only]; Region: COG0627
1198627002993	trigger factor; Provisional; Region: tig; PRK01490
1198627002994	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1198627002995	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1198627002996	Clp protease; Region: CLP_protease; pfam00574
1198627002997	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1198627002998	oligomer interface [polypeptide binding]; other site
1198627002999	active site residues [active]
1198627003000	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1198627003001	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1198627003002	oligomer interface [polypeptide binding]; other site
1198627003003	active site residues [active]
1198627003004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1198627003005	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1198627003006	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1198627003007	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1198627003008	putative di-iron ligands [ion binding]; other site
1198627003009	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1198627003010	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1198627003011	FAD binding pocket [chemical binding]; other site
1198627003012	FAD binding motif [chemical binding]; other site
1198627003013	phosphate binding motif [ion binding]; other site
1198627003014	beta-alpha-beta structure motif; other site
1198627003015	NAD binding pocket [chemical binding]; other site
1198627003016	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627003017	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1198627003018	catalytic loop [active]
1198627003019	iron binding site [ion binding]; other site
1198627003020	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1198627003021	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627003022	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1198627003023	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1198627003024	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1198627003025	putative molybdopterin cofactor binding site [chemical binding]; other site
1198627003026	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1198627003027	putative molybdopterin cofactor binding site; other site
1198627003028	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1198627003029	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1198627003030	GTP binding site; other site
1198627003031	hypothetical protein; Provisional; Region: PRK06753
1198627003032	hypothetical protein; Provisional; Region: PRK07236
1198627003033	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1198627003034	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1198627003035	active site
1198627003036	HIGH motif; other site
1198627003037	nucleotide binding site [chemical binding]; other site
1198627003038	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1198627003039	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1198627003040	active site
1198627003041	KMSKS motif; other site
1198627003042	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1198627003043	tRNA binding surface [nucleotide binding]; other site
1198627003044	anticodon binding site; other site
1198627003045	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1198627003046	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1198627003047	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1198627003048	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1198627003049	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1198627003050	active site
1198627003051	multimer interface [polypeptide binding]; other site
1198627003052	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1198627003053	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1198627003054	homodimer interface [polypeptide binding]; other site
1198627003055	oligonucleotide binding site [chemical binding]; other site
1198627003056	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1198627003057	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1198627003058	GTP1/OBG; Region: GTP1_OBG; pfam01018
1198627003059	Obg GTPase; Region: Obg; cd01898
1198627003060	G1 box; other site
1198627003061	GTP/Mg2+ binding site [chemical binding]; other site
1198627003062	Switch I region; other site
1198627003063	G2 box; other site
1198627003064	G3 box; other site
1198627003065	Switch II region; other site
1198627003066	G4 box; other site
1198627003067	G5 box; other site
1198627003068	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1198627003069	gamma-glutamyl kinase; Provisional; Region: PRK05429
1198627003070	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1198627003071	nucleotide binding site [chemical binding]; other site
1198627003072	homotetrameric interface [polypeptide binding]; other site
1198627003073	putative phosphate binding site [ion binding]; other site
1198627003074	putative allosteric binding site; other site
1198627003075	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
1198627003076	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1198627003077	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1198627003078	substrate binding site [chemical binding]; other site
1198627003079	dimer interface [polypeptide binding]; other site
1198627003080	ATP binding site [chemical binding]; other site
1198627003081	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1198627003082	putative catalytic cysteine [active]
1198627003083	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1198627003084	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1198627003085	active site
1198627003086	(T/H)XGH motif; other site
1198627003087	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1198627003088	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627003089	catalytic core [active]
1198627003090	EDD domain protein, DegV family; Region: DegV; TIGR00762
1198627003091	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1198627003092	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
1198627003093	Helix-hairpin-helix motif; Region: HHH; pfam00633
1198627003094	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1198627003095	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1198627003096	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1198627003097	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1198627003098	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1198627003099	GTP-binding protein LepA; Provisional; Region: PRK05433
1198627003100	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1198627003101	Switch II region; other site
1198627003102	G4 box; other site
1198627003103	G5 box; other site
1198627003104	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1198627003105	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1198627003106	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1198627003107	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1198627003108	Nitronate monooxygenase; Region: NMO; pfam03060
1198627003109	FMN binding site [chemical binding]; other site
1198627003110	substrate binding site [chemical binding]; other site
1198627003111	putative catalytic residue [active]
1198627003112	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1198627003113	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1198627003114	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1198627003115	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1198627003116	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1198627003117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627003118	dimer interface [polypeptide binding]; other site
1198627003119	conserved gate region; other site
1198627003120	putative PBP binding loops; other site
1198627003121	ABC-ATPase subunit interface; other site
1198627003122	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1198627003123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627003124	dimer interface [polypeptide binding]; other site
1198627003125	conserved gate region; other site
1198627003126	putative PBP binding loops; other site
1198627003127	ABC-ATPase subunit interface; other site
1198627003128	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1198627003129	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1198627003130	Walker A/P-loop; other site
1198627003131	ATP binding site [chemical binding]; other site
1198627003132	Q-loop/lid; other site
1198627003133	ABC transporter signature motif; other site
1198627003134	Walker B; other site
1198627003135	D-loop; other site
1198627003136	H-loop/switch region; other site
1198627003137	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
1198627003138	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1198627003139	CysD dimerization site [polypeptide binding]; other site
1198627003140	G1 box; other site
1198627003141	putative GEF interaction site [polypeptide binding]; other site
1198627003142	GTP/Mg2+ binding site [chemical binding]; other site
1198627003143	Switch I region; other site
1198627003144	G2 box; other site
1198627003145	G3 box; other site
1198627003146	Switch II region; other site
1198627003147	G4 box; other site
1198627003148	G5 box; other site
1198627003149	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1198627003150	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1198627003151	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1198627003152	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1198627003153	Active Sites [active]
1198627003154	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1198627003155	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1198627003156	Active Sites [active]
1198627003157	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1198627003158	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1198627003159	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1198627003160	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1198627003161	HemN C-terminal domain; Region: HemN_C; pfam06969
1198627003162	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1198627003163	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1198627003164	chaperone protein DnaJ; Provisional; Region: PRK14278
1198627003165	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1198627003166	HSP70 interaction site [polypeptide binding]; other site
1198627003167	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1198627003168	Zn binding sites [ion binding]; other site
1198627003169	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1198627003170	dimer interface [polypeptide binding]; other site
1198627003171	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1198627003172	K homology RNA-binding domain; Region: KH; smart00322
1198627003173	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1198627003174	PhoH-like protein; Region: PhoH; pfam02562
1198627003175	metal-binding heat shock protein; Provisional; Region: PRK00016
1198627003176	Domain of unknown function DUF21; Region: DUF21; pfam01595
1198627003177	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1198627003178	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1198627003179	Transporter associated domain; Region: CorC_HlyC; smart01091
1198627003180	GTPase Era; Reviewed; Region: era; PRK00089
1198627003181	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1198627003182	G1 box; other site
1198627003183	GTP/Mg2+ binding site [chemical binding]; other site
1198627003184	Switch I region; other site
1198627003185	G2 box; other site
1198627003186	Switch II region; other site
1198627003187	G3 box; other site
1198627003188	G4 box; other site
1198627003189	G5 box; other site
1198627003190	KH domain; Region: KH_2; pfam07650
1198627003191	amidase; Provisional; Region: PRK06061
1198627003192	Amidase; Region: Amidase; pfam01425
1198627003193	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1198627003194	Recombination protein O N terminal; Region: RecO_N; pfam11967
1198627003195	Recombination protein O C terminal; Region: RecO_C; pfam02565
1198627003196	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1198627003197	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1198627003198	catalytic residue [active]
1198627003199	putative FPP diphosphate  binding site; other site
1198627003200	putative FPP binding hydrophobic cleft; other site
1198627003201	dimer interface [polypeptide binding]; other site
1198627003202	putative IPP diphosphate binding site; other site
1198627003203	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1198627003204	metal binding site 2 [ion binding]; metal-binding site
1198627003205	putative DNA binding helix; other site
1198627003206	metal binding site 1 [ion binding]; metal-binding site
1198627003207	dimer interface [polypeptide binding]; other site
1198627003208	structural Zn2+ binding site [ion binding]; other site
1198627003209	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1198627003210	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627003211	NAD(P) binding site [chemical binding]; other site
1198627003212	active site
1198627003213	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627003214	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627003215	catalytic residue [active]
1198627003216	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627003217	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627003218	catalytic residue [active]
1198627003219	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1198627003220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627003221	Walker A/P-loop; other site
1198627003222	ATP binding site [chemical binding]; other site
1198627003223	Q-loop/lid; other site
1198627003224	ABC transporter signature motif; other site
1198627003225	Walker B; other site
1198627003226	D-loop; other site
1198627003227	H-loop/switch region; other site
1198627003228	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
1198627003229	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627003230	acyl-activating enzyme (AAE) consensus motif; other site
1198627003231	active site
1198627003232	Permease; Region: Permease; pfam02405
1198627003233	Permease; Region: Permease; pfam02405
1198627003234	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1198627003235	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1198627003236	motif 1; other site
1198627003237	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1198627003238	active site
1198627003239	motif 2; other site
1198627003240	motif 3; other site
1198627003241	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1198627003242	anticodon binding site; other site
1198627003243	hypothetical protein; Provisional; Region: PRK06062
1198627003244	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627003245	inhibitor-cofactor binding pocket; inhibition site
1198627003246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627003247	catalytic residue [active]
1198627003248	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1198627003249	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
1198627003250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627003251	catalytic residue [active]
1198627003252	transcriptional regulator NanR; Provisional; Region: PRK03837
1198627003253	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627003254	DNA-binding site [nucleotide binding]; DNA binding site
1198627003255	FCD domain; Region: FCD; pfam07729
1198627003256	Repair protein; Region: Repair_PSII; pfam04536
1198627003257	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1198627003258	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1198627003259	Zn2+ binding site [ion binding]; other site
1198627003260	Mg2+ binding site [ion binding]; other site
1198627003261	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1198627003262	DNA primase; Validated; Region: dnaG; PRK05667
1198627003263	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1198627003264	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1198627003265	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1198627003266	active site
1198627003267	metal binding site [ion binding]; metal-binding site
1198627003268	interdomain interaction site; other site
1198627003269	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1198627003270	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1198627003271	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1198627003272	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1198627003273	Walker A/P-loop; other site
1198627003274	ATP binding site [chemical binding]; other site
1198627003275	Q-loop/lid; other site
1198627003276	ABC transporter signature motif; other site
1198627003277	Walker B; other site
1198627003278	D-loop; other site
1198627003279	H-loop/switch region; other site
1198627003280	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1198627003281	Walker A/P-loop; other site
1198627003282	ATP binding site [chemical binding]; other site
1198627003283	Q-loop/lid; other site
1198627003284	ABC transporter signature motif; other site
1198627003285	Walker B; other site
1198627003286	D-loop; other site
1198627003287	H-loop/switch region; other site
1198627003288	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1198627003289	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1198627003290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627003291	dimer interface [polypeptide binding]; other site
1198627003292	conserved gate region; other site
1198627003293	putative PBP binding loops; other site
1198627003294	ABC-ATPase subunit interface; other site
1198627003295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1198627003296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627003297	ABC-ATPase subunit interface; other site
1198627003298	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1198627003299	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627003300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627003301	active site
1198627003302	phosphorylation site [posttranslational modification]
1198627003303	intermolecular recognition site; other site
1198627003304	dimerization interface [polypeptide binding]; other site
1198627003305	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627003306	DNA binding site [nucleotide binding]
1198627003307	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1198627003308	dimerization interface [polypeptide binding]; other site
1198627003309	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1198627003310	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627003311	dimer interface [polypeptide binding]; other site
1198627003312	phosphorylation site [posttranslational modification]
1198627003313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627003314	ATP binding site [chemical binding]; other site
1198627003315	Mg2+ binding site [ion binding]; other site
1198627003316	G-X-G motif; other site
1198627003317	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1198627003318	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1198627003319	active site
1198627003320	DNA binding site [nucleotide binding]
1198627003321	Int/Topo IB signature motif; other site
1198627003322	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1198627003323	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1198627003324	Beta-lactamase; Region: Beta-lactamase; pfam00144
1198627003325	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1198627003326	catalytic residue [active]
1198627003327	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1198627003328	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1198627003329	catalytic residues [active]
1198627003330	catalytic nucleophile [active]
1198627003331	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1198627003332	Synaptic Flat tetramer interface [polypeptide binding]; other site
1198627003333	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1198627003334	DNA-binding interface [nucleotide binding]; DNA binding site
1198627003335	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1198627003336	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1198627003337	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1198627003338	metal binding site [ion binding]; metal-binding site
1198627003339	active site
1198627003340	I-site; other site
1198627003341	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
1198627003342	putative heme binding pocket [chemical binding]; other site
1198627003343	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
1198627003344	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627003345	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1198627003346	Walker A/P-loop; other site
1198627003347	ATP binding site [chemical binding]; other site
1198627003348	Q-loop/lid; other site
1198627003349	ABC transporter signature motif; other site
1198627003350	Walker B; other site
1198627003351	D-loop; other site
1198627003352	H-loop/switch region; other site
1198627003353	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627003354	Walker A/P-loop; other site
1198627003355	ATP binding site [chemical binding]; other site
1198627003356	Q-loop/lid; other site
1198627003357	ABC transporter signature motif; other site
1198627003358	Walker B; other site
1198627003359	D-loop; other site
1198627003360	H-loop/switch region; other site
1198627003361	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1198627003362	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1198627003363	active site
1198627003364	Zn binding site [ion binding]; other site
1198627003365	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1198627003366	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1198627003367	active site
1198627003368	Zn binding site [ion binding]; other site
1198627003369	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627003370	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627003371	active site
1198627003372	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1198627003373	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1198627003374	active site pocket [active]
1198627003375	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1198627003376	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627003377	Walker A/P-loop; other site
1198627003378	ATP binding site [chemical binding]; other site
1198627003379	Q-loop/lid; other site
1198627003380	ABC transporter signature motif; other site
1198627003381	Walker B; other site
1198627003382	D-loop; other site
1198627003383	H-loop/switch region; other site
1198627003384	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1198627003385	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1198627003386	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627003387	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627003388	active site
1198627003389	lipid-transfer protein; Provisional; Region: PRK08256
1198627003390	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1198627003391	active site
1198627003392	AMP-binding enzyme; Region: AMP-binding; pfam00501
1198627003393	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1198627003394	acyl-activating enzyme (AAE) consensus motif; other site
1198627003395	putative AMP binding site [chemical binding]; other site
1198627003396	putative active site [active]
1198627003397	putative CoA binding site [chemical binding]; other site
1198627003398	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1198627003399	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1198627003400	metal binding site [ion binding]; metal-binding site
1198627003401	active site
1198627003402	I-site; other site
1198627003403	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1198627003404	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1198627003405	active site
1198627003406	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
1198627003407	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1198627003408	NAD binding site [chemical binding]; other site
1198627003409	catalytic Zn binding site [ion binding]; other site
1198627003410	substrate binding site [chemical binding]; other site
1198627003411	structural Zn binding site [ion binding]; other site
1198627003412	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1198627003413	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1198627003414	putative NAD(P) binding site [chemical binding]; other site
1198627003415	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1198627003416	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1198627003417	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1198627003418	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1198627003419	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1198627003420	dimer interface [polypeptide binding]; other site
1198627003421	active site
1198627003422	acyl carrier protein; Provisional; Region: acpP; PRK00982
1198627003423	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1198627003424	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1198627003425	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1198627003426	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1198627003427	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627003428	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627003429	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1198627003430	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1198627003431	dimer interface [polypeptide binding]; other site
1198627003432	TPP-binding site [chemical binding]; other site
1198627003433	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1198627003434	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1198627003435	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
1198627003436	dimer interface [polypeptide binding]; other site
1198627003437	catalytic triad [active]
1198627003438	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1198627003439	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1198627003440	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1198627003441	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1198627003442	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1198627003443	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1198627003444	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1198627003445	active site
1198627003446	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1198627003447	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1198627003448	motif I; other site
1198627003449	active site
1198627003450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627003451	motif II; other site
1198627003452	hypothetical protein; Provisional; Region: PRK07908
1198627003453	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627003454	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627003455	homodimer interface [polypeptide binding]; other site
1198627003456	catalytic residue [active]
1198627003457	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1198627003458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1198627003459	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1198627003460	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1198627003461	Putative zinc ribbon domain; Region: DUF164; pfam02591
1198627003462	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
1198627003463	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1198627003464	RNA/DNA hybrid binding site [nucleotide binding]; other site
1198627003465	active site
1198627003466	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627003467	catalytic core [active]
1198627003468	MoxR-like ATPases [General function prediction only]; Region: COG0714
1198627003469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627003470	Walker A motif; other site
1198627003471	ATP binding site [chemical binding]; other site
1198627003472	Walker B motif; other site
1198627003473	arginine finger; other site
1198627003474	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1198627003475	RNB domain; Region: RNB; pfam00773
1198627003476	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1198627003477	putative active site; other site
1198627003478	putative metal binding residues [ion binding]; other site
1198627003479	signature motif; other site
1198627003480	putative triphosphate binding site [ion binding]; other site
1198627003481	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1198627003482	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1198627003483	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627003484	acyl-activating enzyme (AAE) consensus motif; other site
1198627003485	active site
1198627003486	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1198627003487	oligomerization interface [polypeptide binding]; other site
1198627003488	active site
1198627003489	metal binding site [ion binding]; metal-binding site
1198627003490	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1198627003491	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1198627003492	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1198627003493	TAP-like protein; Region: Abhydrolase_4; pfam08386
1198627003494	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1198627003495	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1198627003496	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1198627003497	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1198627003498	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1198627003499	metal binding triad; other site
1198627003500	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1198627003501	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1198627003502	metal binding triad; other site
1198627003503	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1198627003504	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627003505	MarR family; Region: MarR_2; pfam12802
1198627003506	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627003507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627003508	active site
1198627003509	phosphorylation site [posttranslational modification]
1198627003510	intermolecular recognition site; other site
1198627003511	dimerization interface [polypeptide binding]; other site
1198627003512	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627003513	DNA binding site [nucleotide binding]
1198627003514	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1198627003515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627003516	phosphorylation site [posttranslational modification]
1198627003517	dimer interface [polypeptide binding]; other site
1198627003518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627003519	Mg2+ binding site [ion binding]; other site
1198627003520	G-X-G motif; other site
1198627003521	Predicted membrane protein [Function unknown]; Region: COG2259
1198627003522	chaperone protein HchA; Provisional; Region: PRK04155
1198627003523	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1198627003524	conserved cys residue [active]
1198627003525	glutamine synthetase, type I; Region: GlnA; TIGR00653
1198627003526	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1198627003527	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1198627003528	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1198627003529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627003530	putative substrate translocation pore; other site
1198627003531	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627003532	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627003533	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627003534	Cytochrome P450; Region: p450; cl12078
1198627003535	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1198627003536	lipoyl synthase; Provisional; Region: PRK05481
1198627003537	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627003538	FeS/SAM binding site; other site
1198627003539	lipoate-protein ligase B; Provisional; Region: PRK14345
1198627003540	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1198627003541	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1198627003542	putative NAD(P) binding site [chemical binding]; other site
1198627003543	putative active site [active]
1198627003544	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1198627003545	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1198627003546	E3 interaction surface; other site
1198627003547	lipoyl attachment site [posttranslational modification]; other site
1198627003548	e3 binding domain; Region: E3_binding; pfam02817
1198627003549	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1198627003550	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1198627003551	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1198627003552	interface (dimer of trimers) [polypeptide binding]; other site
1198627003553	Substrate-binding/catalytic site; other site
1198627003554	Zn-binding sites [ion binding]; other site
1198627003555	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1198627003556	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1198627003557	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1198627003558	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1198627003559	homodimer interface [polypeptide binding]; other site
1198627003560	substrate-cofactor binding pocket; other site
1198627003561	catalytic residue [active]
1198627003562	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1198627003563	active site
1198627003564	metal binding site [ion binding]; metal-binding site
1198627003565	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1198627003566	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1198627003567	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1198627003568	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1198627003569	putative dimer interface [polypeptide binding]; other site
1198627003570	active site pocket [active]
1198627003571	putative cataytic base [active]
1198627003572	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1198627003573	homotrimer interface [polypeptide binding]; other site
1198627003574	Walker A motif; other site
1198627003575	GTP binding site [chemical binding]; other site
1198627003576	Walker B motif; other site
1198627003577	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1198627003578	Glycerate kinase family; Region: Gly_kinase; cl00841
1198627003579	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
1198627003580	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1198627003581	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1198627003582	substrate binding site [chemical binding]; other site
1198627003583	ATP binding site [chemical binding]; other site
1198627003584	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1198627003585	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1198627003586	dimer interface [polypeptide binding]; other site
1198627003587	active site
1198627003588	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1198627003589	Ligand Binding Site [chemical binding]; other site
1198627003590	Molecular Tunnel; other site
1198627003591	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1198627003592	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1198627003593	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1198627003594	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
1198627003595	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1198627003596	heme bH binding site [chemical binding]; other site
1198627003597	intrachain domain interface; other site
1198627003598	heme bL binding site [chemical binding]; other site
1198627003599	interchain domain interface [polypeptide binding]; other site
1198627003600	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1198627003601	Qo binding site; other site
1198627003602	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1198627003603	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1198627003604	iron-sulfur cluster [ion binding]; other site
1198627003605	[2Fe-2S] cluster binding site [ion binding]; other site
1198627003606	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1198627003607	Cytochrome c; Region: Cytochrom_C; pfam00034
1198627003608	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1198627003609	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1198627003610	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1198627003611	Subunit I/III interface [polypeptide binding]; other site
1198627003612	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1198627003613	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1198627003614	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1198627003615	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1198627003616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627003617	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1198627003618	NlpC/P60 family; Region: NLPC_P60; pfam00877
1198627003619	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1198627003620	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1198627003621	acyl-activating enzyme (AAE) consensus motif; other site
1198627003622	putative AMP binding site [chemical binding]; other site
1198627003623	putative active site [active]
1198627003624	putative CoA binding site [chemical binding]; other site
1198627003625	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1198627003626	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1198627003627	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1198627003628	P loop; other site
1198627003629	Nucleotide binding site [chemical binding]; other site
1198627003630	DTAP/Switch II; other site
1198627003631	Switch I; other site
1198627003632	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1198627003633	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1198627003634	putative acyl-acceptor binding pocket; other site
1198627003635	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1198627003636	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1198627003637	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1198627003638	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1198627003639	active site
1198627003640	ATP binding site [chemical binding]; other site
1198627003641	substrate binding site [chemical binding]; other site
1198627003642	activation loop (A-loop); other site
1198627003643	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1198627003644	FAD binding site [chemical binding]; other site
1198627003645	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1198627003646	MraZ protein; Region: MraZ; pfam02381
1198627003647	MraZ protein; Region: MraZ; pfam02381
1198627003648	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1198627003649	MraW methylase family; Region: Methyltransf_5; cl17771
1198627003650	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1198627003651	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1198627003652	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1198627003653	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1198627003654	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1198627003655	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1198627003656	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1198627003657	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1198627003658	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1198627003659	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1198627003660	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1198627003661	Mg++ binding site [ion binding]; other site
1198627003662	putative catalytic motif [active]
1198627003663	putative substrate binding site [chemical binding]; other site
1198627003664	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
1198627003665	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1198627003666	cell division protein FtsW; Region: ftsW; TIGR02614
1198627003667	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1198627003668	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1198627003669	active site
1198627003670	homodimer interface [polypeptide binding]; other site
1198627003671	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1198627003672	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1198627003673	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1198627003674	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1198627003675	Cell division protein FtsQ; Region: FtsQ; pfam03799
1198627003676	cell division protein FtsZ; Validated; Region: PRK09330
1198627003677	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1198627003678	nucleotide binding site [chemical binding]; other site
1198627003679	SulA interaction site; other site
1198627003680	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1198627003681	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1198627003682	catalytic residue [active]
1198627003683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1198627003684	DivIVA domain; Region: DivI1A_domain; TIGR03544
1198627003685	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1198627003686	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1198627003687	amidase; Validated; Region: PRK06565
1198627003688	Amidase; Region: Amidase; cl11426
1198627003689	Amidase; Region: Amidase; cl11426
1198627003690	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1198627003691	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1198627003692	Na binding site [ion binding]; other site
1198627003693	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1198627003694	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1198627003695	dimer interface [polypeptide binding]; other site
1198627003696	active site
1198627003697	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1198627003698	dimer interface [polypeptide binding]; other site
1198627003699	active site
1198627003700	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1198627003701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627003702	NAD(P) binding site [chemical binding]; other site
1198627003703	active site
1198627003704	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1198627003705	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1198627003706	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1198627003707	acyltransferase PapA5; Provisional; Region: PRK09294
1198627003708	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627003709	Transport protein; Region: actII; TIGR00833
1198627003710	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627003711	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627003712	substrate binding pocket [chemical binding]; other site
1198627003713	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1198627003714	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188
1198627003715	NAD(P) binding site [chemical binding]; other site
1198627003716	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627003717	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627003718	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1198627003719	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627003720	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627003721	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627003722	Cytochrome P450; Region: p450; cl12078
1198627003723	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1198627003724	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627003725	catalytic loop [active]
1198627003726	iron binding site [ion binding]; other site
1198627003727	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1198627003728	Helix-turn-helix domain; Region: HTH_18; pfam12833
1198627003729	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627003730	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627003731	methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271
1198627003732	enoyl-CoA hydratase; Provisional; Region: PRK06494
1198627003733	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627003734	substrate binding site [chemical binding]; other site
1198627003735	oxyanion hole (OAH) forming residues; other site
1198627003736	trimer interface [polypeptide binding]; other site
1198627003737	TIGR03084 family protein; Region: TIGR03084
1198627003738	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1198627003739	Wyosine base formation; Region: Wyosine_form; pfam08608
1198627003740	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627003741	CoA binding site [chemical binding]; other site
1198627003742	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627003743	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1198627003744	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1198627003745	active site
1198627003746	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1198627003747	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1198627003748	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1198627003749	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1198627003750	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1198627003751	carboxyltransferase (CT) interaction site; other site
1198627003752	biotinylation site [posttranslational modification]; other site
1198627003753	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1198627003754	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1198627003755	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1198627003756	classical (c) SDRs; Region: SDR_c; cd05233
1198627003757	NAD(P) binding site [chemical binding]; other site
1198627003758	active site
1198627003759	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627003760	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627003761	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627003762	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627003763	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627003764	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627003765	3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141
1198627003766	Cytochrome P450; Region: p450; cl12078
1198627003767	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1198627003768	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1198627003769	dimer interface [polypeptide binding]; other site
1198627003770	acyl-activating enzyme (AAE) consensus motif; other site
1198627003771	putative active site [active]
1198627003772	AMP binding site [chemical binding]; other site
1198627003773	putative CoA binding site [chemical binding]; other site
1198627003774	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627003775	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627003776	active site
1198627003777	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
1198627003778	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1198627003779	NAD binding site [chemical binding]; other site
1198627003780	catalytic Zn binding site [ion binding]; other site
1198627003781	substrate binding site [chemical binding]; other site
1198627003782	structural Zn binding site [ion binding]; other site
1198627003783	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627003784	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627003785	active site
1198627003786	Integrase core domain; Region: rve; pfam00665
1198627003787	Integrase core domain; Region: rve_3; cl15866
1198627003788	Integrase core domain; Region: rve; pfam00665
1198627003789	Integrase core domain; Region: rve_2; pfam13333
1198627003790	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
1198627003791	nudix motif; other site
1198627003792	hypothetical protein; Provisional; Region: PRK07906
1198627003793	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1198627003794	putative metal binding site [ion binding]; other site
1198627003795	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1198627003796	substrate binding site [chemical binding]; other site
1198627003797	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1198627003798	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1198627003799	quinone interaction residues [chemical binding]; other site
1198627003800	active site
1198627003801	catalytic residues [active]
1198627003802	FMN binding site [chemical binding]; other site
1198627003803	substrate binding site [chemical binding]; other site
1198627003804	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1198627003805	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627003806	catalytic core [active]
1198627003807	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1198627003808	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627003809	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1198627003810	active site
1198627003811	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1198627003812	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
1198627003813	active site
1198627003814	HIGH motif; other site
1198627003815	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1198627003816	active site
1198627003817	KMSKS motif; other site
1198627003818	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
1198627003819	putative tRNA binding surface [nucleotide binding]; other site
1198627003820	short chain dehydrogenase; Provisional; Region: PRK05872
1198627003821	classical (c) SDRs; Region: SDR_c; cd05233
1198627003822	NAD(P) binding site [chemical binding]; other site
1198627003823	active site
1198627003824	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1198627003825	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1198627003826	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1198627003827	NADP binding site [chemical binding]; other site
1198627003828	active site
1198627003829	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1198627003830	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1198627003831	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1198627003832	active site
1198627003833	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1198627003834	Condensation domain; Region: Condensation; pfam00668
1198627003835	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627003836	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1198627003837	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627003838	acyl-activating enzyme (AAE) consensus motif; other site
1198627003839	AMP binding site [chemical binding]; other site
1198627003840	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627003841	Condensation domain; Region: Condensation; pfam00668
1198627003842	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627003843	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1198627003844	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627003845	Condensation domain; Region: Condensation; pfam00668
1198627003846	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627003847	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627003848	acyl-activating enzyme (AAE) consensus motif; other site
1198627003849	AMP binding site [chemical binding]; other site
1198627003850	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627003851	Condensation domain; Region: Condensation; pfam00668
1198627003852	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1198627003853	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1198627003854	Condensation domain; Region: Condensation; pfam00668
1198627003855	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627003856	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1198627003857	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1198627003858	acyl-activating enzyme (AAE) consensus motif; other site
1198627003859	AMP binding site [chemical binding]; other site
1198627003860	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627003861	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1198627003862	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1198627003863	phosphate binding site [ion binding]; other site
1198627003864	Predicted membrane protein [Function unknown]; Region: COG2860
1198627003865	UPF0126 domain; Region: UPF0126; pfam03458
1198627003866	UPF0126 domain; Region: UPF0126; pfam03458
1198627003867	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1198627003868	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1198627003869	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1198627003870	substrate binding pocket [chemical binding]; other site
1198627003871	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1198627003872	B12 binding site [chemical binding]; other site
1198627003873	cobalt ligand [ion binding]; other site
1198627003874	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1198627003875	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1198627003876	homodimer interface [polypeptide binding]; other site
1198627003877	putative metal binding site [ion binding]; other site
1198627003878	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1198627003879	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1198627003880	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1198627003881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1198627003882	active site
1198627003883	phosphorylation site [posttranslational modification]
1198627003884	intermolecular recognition site; other site
1198627003885	dimerization interface [polypeptide binding]; other site
1198627003886	NADH dehydrogenase subunit A; Validated; Region: PRK07928
1198627003887	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1198627003888	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
1198627003889	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1198627003890	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
1198627003891	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1198627003892	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1198627003893	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1198627003894	putative dimer interface [polypeptide binding]; other site
1198627003895	[2Fe-2S] cluster binding site [ion binding]; other site
1198627003896	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
1198627003897	SLBB domain; Region: SLBB; pfam10531
1198627003898	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1198627003899	NADH dehydrogenase subunit G; Validated; Region: PRK07860
1198627003900	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627003901	catalytic loop [active]
1198627003902	iron binding site [ion binding]; other site
1198627003903	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1198627003904	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1198627003905	molybdopterin cofactor binding site; other site
1198627003906	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1198627003907	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1198627003908	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1198627003909	4Fe-4S binding domain; Region: Fer4; pfam00037
1198627003910	4Fe-4S binding domain; Region: Fer4; pfam00037
1198627003911	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1198627003912	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1198627003913	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1198627003914	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1198627003915	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1198627003916	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1198627003917	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1198627003918	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1198627003919	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1198627003920	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1198627003921	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1198627003922	putative di-iron ligands [ion binding]; other site
1198627003923	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627003924	Cytochrome P450; Region: p450; cl12078
1198627003925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1198627003926	MOSC domain; Region: MOSC; pfam03473
1198627003927	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1198627003928	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627003929	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1198627003930	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1198627003931	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
1198627003932	homodimer interface [polypeptide binding]; other site
1198627003933	putative substrate binding pocket [chemical binding]; other site
1198627003934	diiron center [ion binding]; other site
1198627003935	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1198627003936	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1198627003937	ATP binding site [chemical binding]; other site
1198627003938	Mg++ binding site [ion binding]; other site
1198627003939	motif III; other site
1198627003940	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1198627003941	nucleotide binding region [chemical binding]; other site
1198627003942	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1198627003943	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627003944	S-adenosylmethionine binding site [chemical binding]; other site
1198627003945	proteasome ATPase; Region: pup_AAA; TIGR03689
1198627003946	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627003947	Walker A motif; other site
1198627003948	ATP binding site [chemical binding]; other site
1198627003949	Walker B motif; other site
1198627003950	arginine finger; other site
1198627003951	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
1198627003952	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627003953	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627003954	DNA binding residues [nucleotide binding]
1198627003955	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1198627003956	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1198627003957	PYR/PP interface [polypeptide binding]; other site
1198627003958	dimer interface [polypeptide binding]; other site
1198627003959	TPP binding site [chemical binding]; other site
1198627003960	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1198627003961	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1198627003962	TPP-binding site [chemical binding]; other site
1198627003963	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
1198627003964	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1198627003965	active site
1198627003966	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
1198627003967	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627003968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627003969	homodimer interface [polypeptide binding]; other site
1198627003970	catalytic residue [active]
1198627003971	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627003972	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1198627003973	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
1198627003974	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
1198627003975	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1198627003976	active site
1198627003977	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
1198627003978	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1198627003979	active site
1198627003980	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
1198627003981	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1198627003982	substrate binding pocket [chemical binding]; other site
1198627003983	membrane-bound complex binding site; other site
1198627003984	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1198627003985	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1198627003986	Walker A/P-loop; other site
1198627003987	ATP binding site [chemical binding]; other site
1198627003988	Q-loop/lid; other site
1198627003989	ABC transporter signature motif; other site
1198627003990	Walker B; other site
1198627003991	D-loop; other site
1198627003992	H-loop/switch region; other site
1198627003993	Beta-lactamase; Region: Beta-lactamase; pfam00144
1198627003994	Beta-lactamase; Region: Beta-lactamase; pfam00144
1198627003995	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1198627003996	Amidase; Region: Amidase; cl11426
1198627003997	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
1198627003998	putative active site [active]
1198627003999	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1198627004000	Predicted transcriptional regulator [Transcription]; Region: COG2378
1198627004001	WYL domain; Region: WYL; pfam13280
1198627004002	Predicted transcriptional regulator [Transcription]; Region: COG2378
1198627004003	WYL domain; Region: WYL; pfam13280
1198627004004	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1198627004005	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1198627004006	ATP binding site [chemical binding]; other site
1198627004007	putative Mg++ binding site [ion binding]; other site
1198627004008	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1198627004009	nucleotide binding region [chemical binding]; other site
1198627004010	ATP-binding site [chemical binding]; other site
1198627004011	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1198627004012	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1198627004013	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
1198627004014	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1198627004015	active site
1198627004016	metal binding site 1 [ion binding]; metal-binding site
1198627004017	putative 5' ssDNA interaction site; other site
1198627004018	metal binding site 3; metal-binding site
1198627004019	metal binding site 2 [ion binding]; metal-binding site
1198627004020	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1198627004021	putative DNA binding site [nucleotide binding]; other site
1198627004022	putative metal binding site [ion binding]; other site
1198627004023	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1198627004024	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1198627004025	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1198627004026	active site
1198627004027	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1198627004028	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627004029	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1198627004030	NAD(P) binding site [chemical binding]; other site
1198627004031	active site
1198627004032	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1198627004033	active site
1198627004034	putative homodimer interface [polypeptide binding]; other site
1198627004035	SAM binding site [chemical binding]; other site
1198627004036	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1198627004037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627004038	S-adenosylmethionine binding site [chemical binding]; other site
1198627004039	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1198627004040	active site
1198627004041	SAM binding site [chemical binding]; other site
1198627004042	homodimer interface [polypeptide binding]; other site
1198627004043	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1198627004044	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1198627004045	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1198627004046	active site
1198627004047	SAM binding site [chemical binding]; other site
1198627004048	homodimer interface [polypeptide binding]; other site
1198627004049	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1198627004050	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1198627004051	precorrin-3B synthase; Region: CobG; TIGR02435
1198627004052	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1198627004053	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1198627004054	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1198627004055	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1198627004056	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1198627004057	active site
1198627004058	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
1198627004059	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1198627004060	putative active site [active]
1198627004061	catalytic triad [active]
1198627004062	putative dimer interface [polypeptide binding]; other site
1198627004063	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1198627004064	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1198627004065	Ligand binding site; other site
1198627004066	Putative Catalytic site; other site
1198627004067	DXD motif; other site
1198627004068	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627004069	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1198627004070	Transport protein; Region: actII; TIGR00833
1198627004071	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627004072	Enoylreductase; Region: PKS_ER; smart00829
1198627004073	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1198627004074	NAD(P) binding site [chemical binding]; other site
1198627004075	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1198627004076	KR domain; Region: KR; pfam08659
1198627004077	putative NADP binding site [chemical binding]; other site
1198627004078	active site
1198627004079	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1198627004080	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1198627004081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627004082	dimer interface [polypeptide binding]; other site
1198627004083	conserved gate region; other site
1198627004084	putative PBP binding loops; other site
1198627004085	ABC-ATPase subunit interface; other site
1198627004086	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1198627004087	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1198627004088	Walker A/P-loop; other site
1198627004089	ATP binding site [chemical binding]; other site
1198627004090	Q-loop/lid; other site
1198627004091	ABC transporter signature motif; other site
1198627004092	Walker B; other site
1198627004093	D-loop; other site
1198627004094	H-loop/switch region; other site
1198627004095	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1198627004096	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1198627004097	active site
1198627004098	dimer interface [polypeptide binding]; other site
1198627004099	non-prolyl cis peptide bond; other site
1198627004100	insertion regions; other site
1198627004101	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1198627004102	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1198627004103	TspO/MBR family; Region: TspO_MBR; pfam03073
1198627004104	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1198627004105	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1198627004106	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
1198627004107	active site
1198627004108	catalytic residues [active]
1198627004109	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1198627004110	EspG family; Region: ESX-1_EspG; pfam14011
1198627004111	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1198627004112	PPE family; Region: PPE; pfam00823
1198627004113	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1198627004114	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1198627004115	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1198627004116	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1198627004117	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1198627004118	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
1198627004119	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1198627004120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627004121	Walker A motif; other site
1198627004122	ATP binding site [chemical binding]; other site
1198627004123	Walker B motif; other site
1198627004124	arginine finger; other site
1198627004125	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1198627004126	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1198627004127	FAD binding pocket [chemical binding]; other site
1198627004128	FAD binding motif [chemical binding]; other site
1198627004129	phosphate binding motif [ion binding]; other site
1198627004130	NAD binding pocket [chemical binding]; other site
1198627004131	hypothetical protein; Provisional; Region: PRK07538
1198627004132	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1198627004133	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1198627004134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627004135	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
1198627004136	putative dimerization interface [polypeptide binding]; other site
1198627004137	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627004138	DNA-binding site [nucleotide binding]; DNA binding site
1198627004139	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1198627004140	UTRA domain; Region: UTRA; pfam07702
1198627004141	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1198627004142	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1198627004143	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1198627004144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627004145	dimer interface [polypeptide binding]; other site
1198627004146	conserved gate region; other site
1198627004147	putative PBP binding loops; other site
1198627004148	ABC-ATPase subunit interface; other site
1198627004149	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1198627004150	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1198627004151	Walker A/P-loop; other site
1198627004152	ATP binding site [chemical binding]; other site
1198627004153	Q-loop/lid; other site
1198627004154	ABC transporter signature motif; other site
1198627004155	Walker B; other site
1198627004156	D-loop; other site
1198627004157	H-loop/switch region; other site
1198627004158	L-aspartate oxidase; Provisional; Region: PRK06175
1198627004159	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1198627004160	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
1198627004161	HEAT repeats; Region: HEAT_2; pfam13646
1198627004162	protein binding surface [polypeptide binding]; other site
1198627004163	HEAT repeats; Region: HEAT_2; pfam13646
1198627004164	salicylate synthase MbtI; Reviewed; Region: PRK07912
1198627004165	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1198627004166	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1198627004167	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1198627004168	acyl-activating enzyme (AAE) consensus motif; other site
1198627004169	active site
1198627004170	AMP binding site [chemical binding]; other site
1198627004171	substrate binding site [chemical binding]; other site
1198627004172	Condensation domain; Region: Condensation; pfam00668
1198627004173	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627004174	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627004175	acyl-activating enzyme (AAE) consensus motif; other site
1198627004176	AMP binding site [chemical binding]; other site
1198627004177	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627004178	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1198627004179	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
1198627004180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627004181	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1198627004182	PPE family; Region: PPE; pfam00823
1198627004183	Condensation domain; Region: Condensation; pfam00668
1198627004184	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627004185	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1198627004186	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627004187	acyl-activating enzyme (AAE) consensus motif; other site
1198627004188	AMP binding site [chemical binding]; other site
1198627004189	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627004190	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1198627004191	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1198627004192	active site
1198627004193	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1198627004194	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1198627004195	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627004196	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1198627004197	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1198627004198	active site
1198627004199	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1198627004200	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1198627004201	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1198627004202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627004203	S-adenosylmethionine binding site [chemical binding]; other site
1198627004204	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627004205	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004206	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1198627004207	acyl-activating enzyme (AAE) consensus motif; other site
1198627004208	AMP binding site [chemical binding]; other site
1198627004209	active site
1198627004210	CoA binding site [chemical binding]; other site
1198627004211	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1198627004212	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1198627004213	putative NADP binding site [chemical binding]; other site
1198627004214	active site
1198627004215	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627004216	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627004217	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1198627004218	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
1198627004219	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
1198627004220	active site
1198627004221	substrate binding site [chemical binding]; other site
1198627004222	cosubstrate binding site; other site
1198627004223	catalytic site [active]
1198627004224	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
1198627004225	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1198627004226	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627004227	Walker A/P-loop; other site
1198627004228	ATP binding site [chemical binding]; other site
1198627004229	Q-loop/lid; other site
1198627004230	ABC transporter signature motif; other site
1198627004231	Walker B; other site
1198627004232	D-loop; other site
1198627004233	H-loop/switch region; other site
1198627004234	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1198627004235	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1198627004236	FAD binding pocket [chemical binding]; other site
1198627004237	FAD binding motif [chemical binding]; other site
1198627004238	phosphate binding motif [ion binding]; other site
1198627004239	NAD binding pocket [chemical binding]; other site
1198627004240	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1198627004241	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1198627004242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627004243	Walker A/P-loop; other site
1198627004244	ATP binding site [chemical binding]; other site
1198627004245	Q-loop/lid; other site
1198627004246	ABC transporter signature motif; other site
1198627004247	Walker B; other site
1198627004248	D-loop; other site
1198627004249	H-loop/switch region; other site
1198627004250	metabolite-proton symporter; Region: 2A0106; TIGR00883
1198627004251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627004252	putative substrate translocation pore; other site
1198627004253	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1198627004254	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
1198627004255	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627004256	inhibitor-cofactor binding pocket; inhibition site
1198627004257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627004258	catalytic residue [active]
1198627004259	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1198627004260	Coenzyme A binding pocket [chemical binding]; other site
1198627004261	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1198627004262	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1198627004263	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1198627004264	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1198627004265	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627004266	DNA-binding site [nucleotide binding]; DNA binding site
1198627004267	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1198627004268	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1198627004269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627004270	putative substrate translocation pore; other site
1198627004271	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1198627004272	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1198627004273	DNA binding site [nucleotide binding]
1198627004274	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
1198627004275	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1198627004276	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627004277	NAD(P) binding site [chemical binding]; other site
1198627004278	catalytic residues [active]
1198627004279	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627004280	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
1198627004281	inhibitor-cofactor binding pocket; inhibition site
1198627004282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627004283	catalytic residue [active]
1198627004284	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1198627004285	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1198627004286	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1198627004287	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1198627004288	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1198627004289	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627004290	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627004291	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627004292	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627004293	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1198627004294	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627004295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627004296	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1198627004297	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1198627004298	RNA binding site [nucleotide binding]; other site
1198627004299	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1198627004300	RNA binding site [nucleotide binding]; other site
1198627004301	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1198627004302	RNA binding site [nucleotide binding]; other site
1198627004303	S1 RNA binding domain; Region: S1; pfam00575
1198627004304	RNA binding site [nucleotide binding]; other site
1198627004305	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
1198627004306	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1198627004307	CoA-binding site [chemical binding]; other site
1198627004308	ATP-binding [chemical binding]; other site
1198627004309	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1198627004310	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627004311	Transport protein; Region: actII; TIGR00833
1198627004312	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627004313	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1198627004314	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1198627004315	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1198627004316	excinuclease ABC subunit B; Provisional; Region: PRK05298
1198627004317	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1198627004318	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1198627004319	nucleotide binding region [chemical binding]; other site
1198627004320	ATP-binding site [chemical binding]; other site
1198627004321	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1198627004322	UvrB/uvrC motif; Region: UVR; pfam02151
1198627004323	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1198627004324	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1198627004325	DNA binding residues [nucleotide binding]
1198627004326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627004327	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1198627004328	Ligand Binding Site [chemical binding]; other site
1198627004329	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1198627004330	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1198627004331	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1198627004332	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1198627004333	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1198627004334	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004335	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
1198627004336	acyl-activating enzyme (AAE) consensus motif; other site
1198627004337	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004338	AMP binding site [chemical binding]; other site
1198627004339	active site
1198627004340	acyl-activating enzyme (AAE) consensus motif; other site
1198627004341	CoA binding site [chemical binding]; other site
1198627004342	Putative esterase; Region: Esterase; pfam00756
1198627004343	Protein of unknown function (DUF585); Region: DUF585; pfam04522
1198627004344	S-formylglutathione hydrolase; Region: PLN02442
1198627004345	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
1198627004346	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1198627004347	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1198627004348	dimer interface [polypeptide binding]; other site
1198627004349	putative anticodon binding site; other site
1198627004350	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1198627004351	motif 1; other site
1198627004352	dimer interface [polypeptide binding]; other site
1198627004353	active site
1198627004354	motif 2; other site
1198627004355	motif 3; other site
1198627004356	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1198627004357	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1198627004358	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1198627004359	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1198627004360	23S rRNA binding site [nucleotide binding]; other site
1198627004361	L21 binding site [polypeptide binding]; other site
1198627004362	L13 binding site [polypeptide binding]; other site
1198627004363	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1198627004364	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1198627004365	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1198627004366	short chain dehydrogenase; Provisional; Region: PRK06197
1198627004367	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627004368	NAD(P) binding site [chemical binding]; other site
1198627004369	active site
1198627004370	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1198627004371	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1198627004372	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1198627004373	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1198627004374	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1198627004375	helix-hairpin-helix signature motif; other site
1198627004376	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1198627004377	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1198627004378	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1198627004379	dimer interface [polypeptide binding]; other site
1198627004380	motif 1; other site
1198627004381	active site
1198627004382	motif 2; other site
1198627004383	motif 3; other site
1198627004384	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1198627004385	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1198627004386	putative tRNA-binding site [nucleotide binding]; other site
1198627004387	B3/4 domain; Region: B3_4; pfam03483
1198627004388	tRNA synthetase B5 domain; Region: B5; smart00874
1198627004389	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1198627004390	dimer interface [polypeptide binding]; other site
1198627004391	motif 1; other site
1198627004392	motif 3; other site
1198627004393	motif 2; other site
1198627004394	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1198627004395	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1198627004396	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1198627004397	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1198627004398	heterotetramer interface [polypeptide binding]; other site
1198627004399	active site pocket [active]
1198627004400	cleavage site
1198627004401	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1198627004402	feedback inhibition sensing region; other site
1198627004403	homohexameric interface [polypeptide binding]; other site
1198627004404	nucleotide binding site [chemical binding]; other site
1198627004405	N-acetyl-L-glutamate binding site [chemical binding]; other site
1198627004406	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1198627004407	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627004408	inhibitor-cofactor binding pocket; inhibition site
1198627004409	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627004410	catalytic residue [active]
1198627004411	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1198627004412	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1198627004413	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1198627004414	arginine repressor; Provisional; Region: PRK03341
1198627004415	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1198627004416	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1198627004417	argininosuccinate synthase; Provisional; Region: PRK13820
1198627004418	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1198627004419	ANP binding site [chemical binding]; other site
1198627004420	Substrate Binding Site II [chemical binding]; other site
1198627004421	Substrate Binding Site I [chemical binding]; other site
1198627004422	argininosuccinate lyase; Provisional; Region: PRK00855
1198627004423	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1198627004424	active sites [active]
1198627004425	tetramer interface [polypeptide binding]; other site
1198627004426	acyl-CoA synthetase; Validated; Region: PRK07868
1198627004427	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004428	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004429	acyl-activating enzyme (AAE) consensus motif; other site
1198627004430	AMP binding site [chemical binding]; other site
1198627004431	active site
1198627004432	CoA binding site [chemical binding]; other site
1198627004433	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1198627004434	active site
1198627004435	DNA binding site [nucleotide binding]
1198627004436	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1198627004437	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1198627004438	active site
1198627004439	HIGH motif; other site
1198627004440	dimer interface [polypeptide binding]; other site
1198627004441	KMSKS motif; other site
1198627004442	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1198627004443	RNA binding surface [nucleotide binding]; other site
1198627004444	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1198627004445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627004446	Walker A/P-loop; other site
1198627004447	ATP binding site [chemical binding]; other site
1198627004448	Q-loop/lid; other site
1198627004449	ABC transporter signature motif; other site
1198627004450	Walker B; other site
1198627004451	D-loop; other site
1198627004452	H-loop/switch region; other site
1198627004453	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627004454	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1198627004455	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627004456	active site
1198627004457	motif I; other site
1198627004458	motif II; other site
1198627004459	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1198627004460	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1198627004461	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1198627004462	RNA binding surface [nucleotide binding]; other site
1198627004463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627004464	S-adenosylmethionine binding site [chemical binding]; other site
1198627004465	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1198627004466	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1198627004467	DNA repair protein RecN; Region: recN; TIGR00634
1198627004468	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1198627004469	Walker A/P-loop; other site
1198627004470	ATP binding site [chemical binding]; other site
1198627004471	Q-loop/lid; other site
1198627004472	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1198627004473	ABC transporter signature motif; other site
1198627004474	Walker B; other site
1198627004475	D-loop; other site
1198627004476	H-loop/switch region; other site
1198627004477	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
1198627004478	CTP synthetase; Validated; Region: pyrG; PRK05380
1198627004479	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1198627004480	Catalytic site [active]
1198627004481	active site
1198627004482	UTP binding site [chemical binding]; other site
1198627004483	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1198627004484	active site
1198627004485	putative oxyanion hole; other site
1198627004486	catalytic triad [active]
1198627004487	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1198627004488	dimer interface [polypeptide binding]; other site
1198627004489	active site
1198627004490	ADP-ribose binding site [chemical binding]; other site
1198627004491	nudix motif; other site
1198627004492	metal binding site [ion binding]; metal-binding site
1198627004493	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1198627004494	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1198627004495	active site
1198627004496	DNA binding site [nucleotide binding]
1198627004497	Int/Topo IB signature motif; other site
1198627004498	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1198627004499	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1198627004500	P-loop; other site
1198627004501	Magnesium ion binding site [ion binding]; other site
1198627004502	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1198627004503	Magnesium ion binding site [ion binding]; other site
1198627004504	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1198627004505	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1198627004506	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1198627004507	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1198627004508	RNA binding surface [nucleotide binding]; other site
1198627004509	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1198627004510	active site
1198627004511	cytidylate kinase; Provisional; Region: cmk; PRK00023
1198627004512	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1198627004513	CMP-binding site; other site
1198627004514	The sites determining sugar specificity; other site
1198627004515	GTP-binding protein Der; Reviewed; Region: PRK03003
1198627004516	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1198627004517	G1 box; other site
1198627004518	GTP/Mg2+ binding site [chemical binding]; other site
1198627004519	Switch I region; other site
1198627004520	G2 box; other site
1198627004521	Switch II region; other site
1198627004522	G3 box; other site
1198627004523	G4 box; other site
1198627004524	G5 box; other site
1198627004525	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1198627004526	G1 box; other site
1198627004527	GTP/Mg2+ binding site [chemical binding]; other site
1198627004528	Switch I region; other site
1198627004529	G2 box; other site
1198627004530	G3 box; other site
1198627004531	Switch II region; other site
1198627004532	G4 box; other site
1198627004533	G5 box; other site
1198627004534	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1198627004535	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1198627004536	active site
1198627004537	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1198627004538	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627004539	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1198627004540	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1198627004541	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1198627004542	FMN-binding pocket [chemical binding]; other site
1198627004543	flavin binding motif; other site
1198627004544	phosphate binding motif [ion binding]; other site
1198627004545	beta-alpha-beta structure motif; other site
1198627004546	NAD binding pocket [chemical binding]; other site
1198627004547	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627004548	catalytic loop [active]
1198627004549	iron binding site [ion binding]; other site
1198627004550	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1198627004551	Phosphotransferase enzyme family; Region: APH; pfam01636
1198627004552	active site
1198627004553	ATP binding site [chemical binding]; other site
1198627004554	antibiotic binding site [chemical binding]; other site
1198627004555	hypothetical protein; Validated; Region: PRK07121
1198627004556	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1198627004557	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627004558	ABC1 family; Region: ABC1; cl17513
1198627004559	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1198627004560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627004561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627004562	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627004563	ABC1 family; Region: ABC1; pfam03109
1198627004564	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1198627004565	active site
1198627004566	ATP binding site [chemical binding]; other site
1198627004567	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1198627004568	hydrophobic ligand binding site; other site
1198627004569	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627004570	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1198627004571	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627004572	active site
1198627004573	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1198627004574	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1198627004575	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1198627004576	nucleotide binding region [chemical binding]; other site
1198627004577	ATP-binding site [chemical binding]; other site
1198627004578	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1198627004579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1198627004580	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1198627004581	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
1198627004582	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1198627004583	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1198627004584	lipoyl attachment site [posttranslational modification]; other site
1198627004585	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1198627004586	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1198627004587	phosphopeptide binding site; other site
1198627004588	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1198627004589	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1198627004590	DNA binding residues [nucleotide binding]
1198627004591	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1198627004592	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1198627004593	DNA binding residues [nucleotide binding]
1198627004594	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1198627004595	putative dimer interface [polypeptide binding]; other site
1198627004596	glycine dehydrogenase; Provisional; Region: PRK05367
1198627004597	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1198627004598	tetramer interface [polypeptide binding]; other site
1198627004599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627004600	catalytic residue [active]
1198627004601	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1198627004602	tetramer interface [polypeptide binding]; other site
1198627004603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627004604	catalytic residue [active]
1198627004605	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1198627004606	metal ion-dependent adhesion site (MIDAS); other site
1198627004607	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1198627004608	active site
1198627004609	Domain of unknown function DUF21; Region: DUF21; pfam01595
1198627004610	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1198627004611	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1198627004612	Domain of unknown function DUF21; Region: DUF21; pfam01595
1198627004613	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1198627004614	Transporter associated domain; Region: CorC_HlyC; smart01091
1198627004615	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
1198627004616	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1198627004617	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1198627004618	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1198627004619	active site
1198627004620	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1198627004621	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1198627004622	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1198627004623	Predicted transcriptional regulator [Transcription]; Region: COG3682
1198627004624	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1198627004625	CoenzymeA binding site [chemical binding]; other site
1198627004626	subunit interaction site [polypeptide binding]; other site
1198627004627	PHB binding site; other site
1198627004628	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1198627004629	alpha-gamma subunit interface [polypeptide binding]; other site
1198627004630	beta-gamma subunit interface [polypeptide binding]; other site
1198627004631	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1198627004632	gamma-beta subunit interface [polypeptide binding]; other site
1198627004633	alpha-beta subunit interface [polypeptide binding]; other site
1198627004634	urease subunit alpha; Reviewed; Region: ureC; PRK13206
1198627004635	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1198627004636	subunit interactions [polypeptide binding]; other site
1198627004637	active site
1198627004638	flap region; other site
1198627004639	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1198627004640	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1198627004641	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1198627004642	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1198627004643	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627004644	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627004645	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1198627004646	short chain dehydrogenase; Provisional; Region: PRK05884
1198627004647	short chain dehydrogenase; Provisional; Region: PRK12939
1198627004648	NAD(P) binding site [chemical binding]; other site
1198627004649	active site
1198627004650	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1198627004651	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1198627004652	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1198627004653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627004654	dimer interface [polypeptide binding]; other site
1198627004655	conserved gate region; other site
1198627004656	putative PBP binding loops; other site
1198627004657	ABC-ATPase subunit interface; other site
1198627004658	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1198627004659	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627004660	Walker A/P-loop; other site
1198627004661	ATP binding site [chemical binding]; other site
1198627004662	Q-loop/lid; other site
1198627004663	ABC transporter signature motif; other site
1198627004664	Walker B; other site
1198627004665	D-loop; other site
1198627004666	H-loop/switch region; other site
1198627004667	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1198627004668	molybdopterin cofactor binding site; other site
1198627004669	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1198627004670	molybdopterin cofactor binding site; other site
1198627004671	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1198627004672	Flavodoxin; Region: Flavodoxin_1; pfam00258
1198627004673	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1198627004674	FAD binding pocket [chemical binding]; other site
1198627004675	FAD binding motif [chemical binding]; other site
1198627004676	catalytic residues [active]
1198627004677	NAD binding pocket [chemical binding]; other site
1198627004678	phosphate binding motif [ion binding]; other site
1198627004679	beta-alpha-beta structure motif; other site
1198627004680	CrcB-like protein; Region: CRCB; pfam02537
1198627004681	competence damage-inducible protein A; Provisional; Region: PRK00549
1198627004682	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1198627004683	putative MPT binding site; other site
1198627004684	Competence-damaged protein; Region: CinA; pfam02464
1198627004685	Pirin-related protein [General function prediction only]; Region: COG1741
1198627004686	Pirin; Region: Pirin; pfam02678
1198627004687	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1198627004688	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627004689	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627004690	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1198627004691	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627004692	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627004693	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1198627004694	Predicted esterase [General function prediction only]; Region: COG0627
1198627004695	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
1198627004696	active site
1198627004697	catalytic triad [active]
1198627004698	oxyanion hole [active]
1198627004699	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1198627004700	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1198627004701	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1198627004702	FAD binding domain; Region: FAD_binding_4; pfam01565
1198627004703	Berberine and berberine like; Region: BBE; pfam08031
1198627004704	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1198627004705	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1198627004706	Walker A/P-loop; other site
1198627004707	ATP binding site [chemical binding]; other site
1198627004708	Q-loop/lid; other site
1198627004709	ABC transporter signature motif; other site
1198627004710	Walker B; other site
1198627004711	D-loop; other site
1198627004712	H-loop/switch region; other site
1198627004713	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1198627004714	NMT1-like family; Region: NMT1_2; pfam13379
1198627004715	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1198627004716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627004717	dimer interface [polypeptide binding]; other site
1198627004718	conserved gate region; other site
1198627004719	putative PBP binding loops; other site
1198627004720	ABC-ATPase subunit interface; other site
1198627004721	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1198627004722	heme bL binding site [chemical binding]; other site
1198627004723	interchain domain interface [polypeptide binding]; other site
1198627004724	intrachain domain interface; other site
1198627004725	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1198627004726	heme bH binding site [chemical binding]; other site
1198627004727	Qo binding site; other site
1198627004728	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
1198627004729	active site
1198627004730	barstar interaction site; other site
1198627004731	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1198627004732	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1198627004733	heme binding site [chemical binding]; other site
1198627004734	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1198627004735	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1198627004736	metal binding site 2 [ion binding]; metal-binding site
1198627004737	putative DNA binding helix; other site
1198627004738	metal binding site 1 [ion binding]; metal-binding site
1198627004739	dimer interface [polypeptide binding]; other site
1198627004740	structural Zn2+ binding site [ion binding]; other site
1198627004741	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627004742	MarR family; Region: MarR; pfam01047
1198627004743	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1198627004744	NlpC/P60 family; Region: NLPC_P60; pfam00877
1198627004745	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627004746	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627004747	metabolite-proton symporter; Region: 2A0106; TIGR00883
1198627004748	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1198627004749	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1198627004750	active site
1198627004751	non-prolyl cis peptide bond; other site
1198627004752	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1198627004753	active site
1198627004754	FMN binding site [chemical binding]; other site
1198627004755	substrate binding site [chemical binding]; other site
1198627004756	3Fe-4S cluster binding site [ion binding]; other site
1198627004757	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
1198627004758	domain_subunit interface; other site
1198627004759	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1198627004760	Ligand Binding Site [chemical binding]; other site
1198627004761	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1198627004762	Ligand Binding Site [chemical binding]; other site
1198627004763	Flavodoxin; Region: Flavodoxin_1; pfam00258
1198627004764	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1198627004765	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1198627004766	FAD binding pocket [chemical binding]; other site
1198627004767	FAD binding motif [chemical binding]; other site
1198627004768	catalytic residues [active]
1198627004769	NAD binding pocket [chemical binding]; other site
1198627004770	phosphate binding motif [ion binding]; other site
1198627004771	beta-alpha-beta structure motif; other site
1198627004772	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1198627004773	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627004774	active site
1198627004775	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
1198627004776	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1198627004777	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1198627004778	active site
1198627004779	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
1198627004780	nucleotide binding site [chemical binding]; other site
1198627004781	SBD interface [polypeptide binding]; other site
1198627004782	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1198627004783	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627004784	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1198627004785	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1198627004786	iron-sulfur cluster [ion binding]; other site
1198627004787	[2Fe-2S] cluster binding site [ion binding]; other site
1198627004788	XFP N-terminal domain; Region: XFP_N; pfam09364
1198627004789	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
1198627004790	XFP C-terminal domain; Region: XFP_C; pfam09363
1198627004791	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1198627004792	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1198627004793	ligand binding site [chemical binding]; other site
1198627004794	flexible hinge region; other site
1198627004795	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1198627004796	putative switch regulator; other site
1198627004797	non-specific DNA interactions [nucleotide binding]; other site
1198627004798	DNA binding site [nucleotide binding]
1198627004799	sequence specific DNA binding site [nucleotide binding]; other site
1198627004800	putative cAMP binding site [chemical binding]; other site
1198627004801	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1198627004802	putative methyltransferase; Provisional; Region: PRK14967
1198627004803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627004804	S-adenosylmethionine binding site [chemical binding]; other site
1198627004805	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
1198627004806	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627004807	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1198627004808	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627004809	DNA binding residues [nucleotide binding]
1198627004810	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1198627004811	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1198627004812	PAS fold; Region: PAS_3; pfam08447
1198627004813	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1198627004814	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1198627004815	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627004816	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627004817	catalytic residue [active]
1198627004818	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1198627004819	PhoU domain; Region: PhoU; pfam01895
1198627004820	PhoU domain; Region: PhoU; pfam01895
1198627004821	hydroperoxidase II; Provisional; Region: katE; PRK11249
1198627004822	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1198627004823	tetramer interface [polypeptide binding]; other site
1198627004824	heme binding pocket [chemical binding]; other site
1198627004825	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1198627004826	domain interactions; other site
1198627004827	putative proline-specific permease; Provisional; Region: proY; PRK10580
1198627004828	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1198627004829	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1198627004830	PYR/PP interface [polypeptide binding]; other site
1198627004831	tetramer interface [polypeptide binding]; other site
1198627004832	dimer interface [polypeptide binding]; other site
1198627004833	TPP binding site [chemical binding]; other site
1198627004834	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1198627004835	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1198627004836	TPP-binding site [chemical binding]; other site
1198627004837	Secretory lipase; Region: LIP; pfam03583
1198627004838	acyl-CoA synthetase; Validated; Region: PRK07788
1198627004839	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004840	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004841	active site
1198627004842	CoA binding site [chemical binding]; other site
1198627004843	AMP binding site [chemical binding]; other site
1198627004844	short chain dehydrogenase; Provisional; Region: PRK07825
1198627004845	classical (c) SDRs; Region: SDR_c; cd05233
1198627004846	NAD(P) binding site [chemical binding]; other site
1198627004847	active site
1198627004848	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1198627004849	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1198627004850	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1198627004851	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1198627004852	active site
1198627004853	catalytic triad [active]
1198627004854	dimer interface [polypeptide binding]; other site
1198627004855	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1198627004856	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1198627004857	active site
1198627004858	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1198627004859	homodimer interface [polypeptide binding]; other site
1198627004860	putative substrate binding pocket [chemical binding]; other site
1198627004861	diiron center [ion binding]; other site
1198627004862	Cellulose binding domain; Region: CBM_2; pfam00553
1198627004863	Isochorismatase family; Region: Isochorismatase; pfam00857
1198627004864	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1198627004865	catalytic triad [active]
1198627004866	conserved cis-peptide bond; other site
1198627004867	carboxylate-amine ligase; Provisional; Region: PRK13517
1198627004868	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1198627004869	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1198627004870	active site
1198627004871	substrate-binding site [chemical binding]; other site
1198627004872	metal-binding site [ion binding]
1198627004873	GTP binding site [chemical binding]; other site
1198627004874	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627004875	dimerization interface [polypeptide binding]; other site
1198627004876	putative DNA binding site [nucleotide binding]; other site
1198627004877	putative Zn2+ binding site [ion binding]; other site
1198627004878	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1198627004879	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1198627004880	putative metal binding site [ion binding]; other site
1198627004881	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1198627004882	arsenical-resistance protein; Region: acr3; TIGR00832
1198627004883	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1198627004884	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1198627004885	active site
1198627004886	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
1198627004887	Transport protein; Region: actII; TIGR00833
1198627004888	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627004889	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1198627004890	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004891	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
1198627004892	acyl-activating enzyme (AAE) consensus motif; other site
1198627004893	putative AMP binding site [chemical binding]; other site
1198627004894	putative active site [active]
1198627004895	putative CoA binding site [chemical binding]; other site
1198627004896	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1198627004897	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1198627004898	The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257
1198627004899	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1198627004900	putative active site [active]
1198627004901	putative metal binding site [ion binding]; other site
1198627004902	YaeQ protein; Region: YaeQ; pfam07152
1198627004903	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627004904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627004905	active site
1198627004906	phosphorylation site [posttranslational modification]
1198627004907	intermolecular recognition site; other site
1198627004908	dimerization interface [polypeptide binding]; other site
1198627004909	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627004910	DNA binding site [nucleotide binding]
1198627004911	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1198627004912	HAMP domain; Region: HAMP; pfam00672
1198627004913	dimerization interface [polypeptide binding]; other site
1198627004914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627004915	dimer interface [polypeptide binding]; other site
1198627004916	phosphorylation site [posttranslational modification]
1198627004917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627004918	ATP binding site [chemical binding]; other site
1198627004919	Mg2+ binding site [ion binding]; other site
1198627004920	G-X-G motif; other site
1198627004921	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1198627004922	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1198627004923	conserved cys residue [active]
1198627004924	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627004925	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1198627004926	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1198627004927	PAS fold; Region: PAS_3; pfam08447
1198627004928	putative active site [active]
1198627004929	heme pocket [chemical binding]; other site
1198627004930	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1198627004931	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1198627004932	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
1198627004933	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1198627004934	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1198627004935	active site
1198627004936	NodB motif; other site
1198627004937	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1198627004938	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1198627004939	hypothetical protein; Provisional; Region: PRK02237
1198627004940	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1198627004941	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1198627004942	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1198627004943	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627004944	dimerization interface [polypeptide binding]; other site
1198627004945	putative DNA binding site [nucleotide binding]; other site
1198627004946	putative Zn2+ binding site [ion binding]; other site
1198627004947	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627004948	putative DNA binding site [nucleotide binding]; other site
1198627004949	putative Zn2+ binding site [ion binding]; other site
1198627004950	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1198627004951	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627004952	active site
1198627004953	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627004954	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
1198627004955	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627004956	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1198627004957	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1198627004958	acyl-CoA synthetase; Provisional; Region: PRK13388
1198627004959	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627004960	acyl-activating enzyme (AAE) consensus motif; other site
1198627004961	AMP binding site [chemical binding]; other site
1198627004962	active site
1198627004963	CoA binding site [chemical binding]; other site
1198627004964	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1198627004965	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1198627004966	inhibitor-cofactor binding pocket; inhibition site
1198627004967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627004968	catalytic residue [active]
1198627004969	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1198627004970	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1198627004971	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1198627004972	DNA polymerase I; Provisional; Region: PRK05755
1198627004973	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1198627004974	active site
1198627004975	metal binding site 1 [ion binding]; metal-binding site
1198627004976	putative 5' ssDNA interaction site; other site
1198627004977	metal binding site 3; metal-binding site
1198627004978	metal binding site 2 [ion binding]; metal-binding site
1198627004979	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1198627004980	putative DNA binding site [nucleotide binding]; other site
1198627004981	putative metal binding site [ion binding]; other site
1198627004982	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1198627004983	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1198627004984	active site
1198627004985	DNA binding site [nucleotide binding]
1198627004986	catalytic site [active]
1198627004987	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1198627004988	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1198627004989	D-pathway; other site
1198627004990	Putative ubiquinol binding site [chemical binding]; other site
1198627004991	Low-spin heme (heme b) binding site [chemical binding]; other site
1198627004992	Putative water exit pathway; other site
1198627004993	Binuclear center (heme o3/CuB) [ion binding]; other site
1198627004994	K-pathway; other site
1198627004995	Putative proton exit pathway; other site
1198627004996	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1198627004997	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1198627004998	Walker A/P-loop; other site
1198627004999	ATP binding site [chemical binding]; other site
1198627005000	Q-loop/lid; other site
1198627005001	ABC transporter signature motif; other site
1198627005002	Walker B; other site
1198627005003	D-loop; other site
1198627005004	H-loop/switch region; other site
1198627005005	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1198627005006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627005007	ABC transporter signature motif; other site
1198627005008	Walker B; other site
1198627005009	D-loop; other site
1198627005010	H-loop/switch region; other site
1198627005011	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1198627005012	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1198627005013	TM-ABC transporter signature motif; other site
1198627005014	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1198627005015	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1198627005016	dimerization interface [polypeptide binding]; other site
1198627005017	ligand binding site [chemical binding]; other site
1198627005018	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1198627005019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627005020	active site
1198627005021	phosphorylation site [posttranslational modification]
1198627005022	intermolecular recognition site; other site
1198627005023	dimerization interface [polypeptide binding]; other site
1198627005024	ANTAR domain; Region: ANTAR; pfam03861
1198627005025	SnoaL-like domain; Region: SnoaL_4; pfam13577
1198627005026	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1198627005027	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1198627005028	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1198627005029	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1198627005030	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1198627005031	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1198627005032	Walker A/P-loop; other site
1198627005033	ATP binding site [chemical binding]; other site
1198627005034	Q-loop/lid; other site
1198627005035	ABC transporter signature motif; other site
1198627005036	Walker B; other site
1198627005037	D-loop; other site
1198627005038	H-loop/switch region; other site
1198627005039	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627005040	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1198627005041	Walker A/P-loop; other site
1198627005042	ATP binding site [chemical binding]; other site
1198627005043	Q-loop/lid; other site
1198627005044	ABC transporter signature motif; other site
1198627005045	Walker B; other site
1198627005046	D-loop; other site
1198627005047	H-loop/switch region; other site
1198627005048	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1198627005049	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1198627005050	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1198627005051	active site
1198627005052	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1198627005053	catalytic triad [active]
1198627005054	dimer interface [polypeptide binding]; other site
1198627005055	pyruvate kinase; Provisional; Region: PRK06247
1198627005056	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1198627005057	domain interfaces; other site
1198627005058	active site
1198627005059	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1198627005060	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
1198627005061	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1198627005062	substrate binding site [chemical binding]; other site
1198627005063	active site
1198627005064	catalytic residues [active]
1198627005065	heterodimer interface [polypeptide binding]; other site
1198627005066	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1198627005067	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1198627005068	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627005069	catalytic residue [active]
1198627005070	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1198627005071	active site
1198627005072	ribulose/triose binding site [chemical binding]; other site
1198627005073	phosphate binding site [ion binding]; other site
1198627005074	substrate (anthranilate) binding pocket [chemical binding]; other site
1198627005075	product (indole) binding pocket [chemical binding]; other site
1198627005076	anthranilate synthase component I; Provisional; Region: PRK13571
1198627005077	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1198627005078	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1198627005079	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627005080	MarR family; Region: MarR_2; pfam12802
1198627005081	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627005082	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1198627005083	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1198627005084	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1198627005085	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627005086	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627005087	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627005088	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1198627005089	active site clefts [active]
1198627005090	zinc binding site [ion binding]; other site
1198627005091	dimer interface [polypeptide binding]; other site
1198627005092	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1198627005093	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1198627005094	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1198627005095	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1198627005096	HIT family signature motif; other site
1198627005097	catalytic residue [active]
1198627005098	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1198627005099	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1198627005100	catalytic triad [active]
1198627005101	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1198627005102	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1198627005103	substrate binding site [chemical binding]; other site
1198627005104	glutamase interaction surface [polypeptide binding]; other site
1198627005105	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1198627005106	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1198627005107	active site
1198627005108	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1198627005109	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1198627005110	catalytic residues [active]
1198627005111	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1198627005112	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1198627005113	putative active site [active]
1198627005114	oxyanion strand; other site
1198627005115	catalytic triad [active]
1198627005116	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1198627005117	putative active site pocket [active]
1198627005118	4-fold oligomerization interface [polypeptide binding]; other site
1198627005119	metal binding residues [ion binding]; metal-binding site
1198627005120	3-fold/trimer interface [polypeptide binding]; other site
1198627005121	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1198627005122	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627005123	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627005124	homodimer interface [polypeptide binding]; other site
1198627005125	catalytic residue [active]
1198627005126	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
1198627005127	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1198627005128	NAD binding site [chemical binding]; other site
1198627005129	dimerization interface [polypeptide binding]; other site
1198627005130	product binding site; other site
1198627005131	substrate binding site [chemical binding]; other site
1198627005132	zinc binding site [ion binding]; other site
1198627005133	catalytic residues [active]
1198627005134	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
1198627005135	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1198627005136	dimerization interface [polypeptide binding]; other site
1198627005137	active site
1198627005138	L-aspartate oxidase; Provisional; Region: PRK07804
1198627005139	L-aspartate oxidase; Provisional; Region: PRK06175
1198627005140	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1198627005141	quinolinate synthetase; Provisional; Region: PRK09375
1198627005142	Secretory lipase; Region: LIP; pfam03583
1198627005143	hypothetical protein; Provisional; Region: PRK07588
1198627005144	hypothetical protein; Provisional; Region: PRK07236
1198627005145	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627005146	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627005147	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1198627005148	dimerization interface [polypeptide binding]; other site
1198627005149	malate:quinone oxidoreductase; Validated; Region: PRK05257
1198627005150	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1198627005151	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
1198627005152	biotin synthase; Validated; Region: PRK06256
1198627005153	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627005154	FeS/SAM binding site; other site
1198627005155	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1198627005156	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627005157	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1198627005158	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1198627005159	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1198627005160	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1198627005161	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627005162	catalytic residue [active]
1198627005163	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1198627005164	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627005165	inhibitor-cofactor binding pocket; inhibition site
1198627005166	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627005167	catalytic residue [active]
1198627005168	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1198627005169	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1198627005170	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1198627005171	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1198627005172	active site
1198627005173	catalytic site [active]
1198627005174	threonine dehydratase; Validated; Region: PRK08639
1198627005175	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1198627005176	tetramer interface [polypeptide binding]; other site
1198627005177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627005178	catalytic residue [active]
1198627005179	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
1198627005180	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1198627005181	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1198627005182	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1198627005183	active site
1198627005184	PHP Thumb interface [polypeptide binding]; other site
1198627005185	metal binding site [ion binding]; metal-binding site
1198627005186	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1198627005187	generic binding surface II; other site
1198627005188	generic binding surface I; other site
1198627005189	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1198627005190	EamA-like transporter family; Region: EamA; cl17759
1198627005191	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1198627005192	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1198627005193	active site
1198627005194	lipoprotein signal peptidase; Provisional; Region: PRK14764
1198627005195	DNA polymerase IV; Provisional; Region: PRK03348
1198627005196	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1198627005197	active site
1198627005198	DNA binding site [nucleotide binding]
1198627005199	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1198627005200	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1198627005201	HIGH motif; other site
1198627005202	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1198627005203	active site
1198627005204	KMSKS motif; other site
1198627005205	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1198627005206	tRNA binding surface [nucleotide binding]; other site
1198627005207	anticodon binding site; other site
1198627005208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627005209	putative substrate translocation pore; other site
1198627005210	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1198627005211	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627005212	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627005213	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1198627005214	putative dimerization interface [polypeptide binding]; other site
1198627005215	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1198627005216	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1198627005217	Walker A; other site
1198627005218	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1198627005219	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1198627005220	active site
1198627005221	substrate binding site [chemical binding]; other site
1198627005222	coenzyme B12 binding site [chemical binding]; other site
1198627005223	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1198627005224	B12 binding site [chemical binding]; other site
1198627005225	cobalt ligand [ion binding]; other site
1198627005226	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
1198627005227	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
1198627005228	heterodimer interface [polypeptide binding]; other site
1198627005229	substrate interaction site [chemical binding]; other site
1198627005230	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1198627005231	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1198627005232	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1198627005233	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1198627005234	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1198627005235	Protein of unknown function (DUF1616); Region: DUF1616; cl01959
1198627005236	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1198627005237	MgtE intracellular N domain; Region: MgtE_N; smart00924
1198627005238	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1198627005239	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1198627005240	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1198627005241	ferrochelatase; Reviewed; Region: hemH; PRK00035
1198627005242	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1198627005243	C-terminal domain interface [polypeptide binding]; other site
1198627005244	active site
1198627005245	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1198627005246	active site
1198627005247	N-terminal domain interface [polypeptide binding]; other site
1198627005248	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
1198627005249	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1198627005250	NAD binding site [chemical binding]; other site
1198627005251	homotetramer interface [polypeptide binding]; other site
1198627005252	homodimer interface [polypeptide binding]; other site
1198627005253	substrate binding site [chemical binding]; other site
1198627005254	active site
1198627005255	hypothetical protein; Provisional; Region: PRK13685
1198627005256	Aerotolerance regulator N-terminal; Region: BatA; cl06567
1198627005257	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1198627005258	metal ion-dependent adhesion site (MIDAS); other site
1198627005259	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1198627005260	Protein of unknown function DUF58; Region: DUF58; pfam01882
1198627005261	MoxR-like ATPases [General function prediction only]; Region: COG0714
1198627005262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627005263	Walker A motif; other site
1198627005264	ATP binding site [chemical binding]; other site
1198627005265	Walker B motif; other site
1198627005266	arginine finger; other site
1198627005267	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1198627005268	NlpC/P60 family; Region: NLPC_P60; pfam00877
1198627005269	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1198627005270	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1198627005271	NlpC/P60 family; Region: NLPC_P60; pfam00877
1198627005272	aconitate hydratase; Validated; Region: PRK09277
1198627005273	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1198627005274	substrate binding site [chemical binding]; other site
1198627005275	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1198627005276	ligand binding site [chemical binding]; other site
1198627005277	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1198627005278	substrate binding site [chemical binding]; other site
1198627005279	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627005280	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627005281	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1198627005282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627005283	Walker A/P-loop; other site
1198627005284	ATP binding site [chemical binding]; other site
1198627005285	Q-loop/lid; other site
1198627005286	ABC transporter signature motif; other site
1198627005287	Walker B; other site
1198627005288	D-loop; other site
1198627005289	H-loop/switch region; other site
1198627005290	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627005291	enoyl-CoA hydratase; Provisional; Region: PRK05864
1198627005292	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627005293	substrate binding site [chemical binding]; other site
1198627005294	oxyanion hole (OAH) forming residues; other site
1198627005295	trimer interface [polypeptide binding]; other site
1198627005296	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1198627005297	catalytic residues [active]
1198627005298	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1198627005299	phosphate binding site [ion binding]; other site
1198627005300	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1198627005301	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1198627005302	Coenzyme A binding pocket [chemical binding]; other site
1198627005303	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1198627005304	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1198627005305	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1198627005306	trimerization site [polypeptide binding]; other site
1198627005307	active site
1198627005308	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1198627005309	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1198627005310	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627005311	catalytic residue [active]
1198627005312	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1198627005313	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1198627005314	Walker A/P-loop; other site
1198627005315	ATP binding site [chemical binding]; other site
1198627005316	Q-loop/lid; other site
1198627005317	ABC transporter signature motif; other site
1198627005318	Walker B; other site
1198627005319	D-loop; other site
1198627005320	H-loop/switch region; other site
1198627005321	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1198627005322	FeS assembly protein SufD; Region: sufD; TIGR01981
1198627005323	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1198627005324	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1198627005325	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1198627005326	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1198627005327	Walker A/P-loop; other site
1198627005328	ATP binding site [chemical binding]; other site
1198627005329	Q-loop/lid; other site
1198627005330	ABC transporter signature motif; other site
1198627005331	Walker B; other site
1198627005332	D-loop; other site
1198627005333	H-loop/switch region; other site
1198627005334	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1198627005335	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1198627005336	NADP binding site [chemical binding]; other site
1198627005337	dimer interface [polypeptide binding]; other site
1198627005338	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1198627005339	UbiA prenyltransferase family; Region: UbiA; pfam01040
1198627005340	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1198627005341	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1198627005342	TPP-binding site [chemical binding]; other site
1198627005343	dimer interface [polypeptide binding]; other site
1198627005344	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1198627005345	PYR/PP interface [polypeptide binding]; other site
1198627005346	dimer interface [polypeptide binding]; other site
1198627005347	TPP binding site [chemical binding]; other site
1198627005348	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1198627005349	transaldolase; Provisional; Region: PRK03903
1198627005350	putative active site [active]
1198627005351	catalytic residue [active]
1198627005352	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1198627005353	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1198627005354	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1198627005355	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1198627005356	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1198627005357	putative active site [active]
1198627005358	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627005359	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627005360	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1198627005361	dimerization interface [polypeptide binding]; other site
1198627005362	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1198627005363	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1198627005364	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
1198627005365	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
1198627005366	Subunit I/III interface [polypeptide binding]; other site
1198627005367	triosephosphate isomerase; Provisional; Region: PRK14567
1198627005368	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1198627005369	substrate binding site [chemical binding]; other site
1198627005370	dimer interface [polypeptide binding]; other site
1198627005371	catalytic triad [active]
1198627005372	Phosphoglycerate kinase; Region: PGK; pfam00162
1198627005373	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1198627005374	substrate binding site [chemical binding]; other site
1198627005375	hinge regions; other site
1198627005376	ADP binding site [chemical binding]; other site
1198627005377	catalytic site [active]
1198627005378	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1198627005379	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1198627005380	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1198627005381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1198627005382	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1198627005383	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1198627005384	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1198627005385	phosphate binding site [ion binding]; other site
1198627005386	putative substrate binding pocket [chemical binding]; other site
1198627005387	dimer interface [polypeptide binding]; other site
1198627005388	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1198627005389	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1198627005390	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1198627005391	GIY-YIG motif/motif A; other site
1198627005392	active site
1198627005393	catalytic site [active]
1198627005394	putative DNA binding site [nucleotide binding]; other site
1198627005395	metal binding site [ion binding]; metal-binding site
1198627005396	UvrB/uvrC motif; Region: UVR; pfam02151
1198627005397	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1198627005398	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1198627005399	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1198627005400	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1198627005401	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1198627005402	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1198627005403	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1198627005404	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1198627005405	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1198627005406	ethanolamine permease; Region: 2A0305; TIGR00908
1198627005407	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1198627005408	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627005409	NAD(P) binding site [chemical binding]; other site
1198627005410	catalytic residues [active]
1198627005411	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1198627005412	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1198627005413	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1198627005414	homopentamer interface [polypeptide binding]; other site
1198627005415	active site
1198627005416	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1198627005417	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1198627005418	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1198627005419	dimerization interface [polypeptide binding]; other site
1198627005420	active site
1198627005421	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1198627005422	Lumazine binding domain; Region: Lum_binding; pfam00677
1198627005423	Lumazine binding domain; Region: Lum_binding; pfam00677
1198627005424	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
1198627005425	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1198627005426	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1198627005427	Walker A/P-loop; other site
1198627005428	ATP binding site [chemical binding]; other site
1198627005429	Q-loop/lid; other site
1198627005430	ABC transporter signature motif; other site
1198627005431	Walker B; other site
1198627005432	D-loop; other site
1198627005433	H-loop/switch region; other site
1198627005434	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1198627005435	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1198627005436	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1198627005437	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1198627005438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627005439	putative substrate translocation pore; other site
1198627005440	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1198627005441	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1198627005442	catalytic motif [active]
1198627005443	Zn binding site [ion binding]; other site
1198627005444	RibD C-terminal domain; Region: RibD_C; pfam01872
1198627005445	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1198627005446	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1198627005447	substrate binding site [chemical binding]; other site
1198627005448	hexamer interface [polypeptide binding]; other site
1198627005449	metal binding site [ion binding]; metal-binding site
1198627005450	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1198627005451	putative RNA binding site [nucleotide binding]; other site
1198627005452	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1198627005453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627005454	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1198627005455	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1198627005456	putative active site [active]
1198627005457	substrate binding site [chemical binding]; other site
1198627005458	putative cosubstrate binding site; other site
1198627005459	catalytic site [active]
1198627005460	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1198627005461	substrate binding site [chemical binding]; other site
1198627005462	primosome assembly protein PriA; Provisional; Region: PRK14873
1198627005463	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627005464	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627005465	substrate binding pocket [chemical binding]; other site
1198627005466	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627005467	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627005468	F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842
1198627005469	phenylhydantoinase; Validated; Region: PRK08323
1198627005470	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1198627005471	tetramer interface [polypeptide binding]; other site
1198627005472	active site
1198627005473	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1198627005474	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1198627005475	active site
1198627005476	catalytic triad [active]
1198627005477	dimer interface [polypeptide binding]; other site
1198627005478	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1198627005479	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1198627005480	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1198627005481	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1198627005482	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1198627005483	Flavoprotein; Region: Flavoprotein; pfam02441
1198627005484	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1198627005485	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1198627005486	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1198627005487	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1198627005488	catalytic site [active]
1198627005489	G-X2-G-X-G-K; other site
1198627005490	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1198627005491	active site
1198627005492	dimer interface [polypeptide binding]; other site
1198627005493	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1198627005494	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1198627005495	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1198627005496	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1198627005497	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1198627005498	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1198627005499	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1198627005500	IMP binding site; other site
1198627005501	dimer interface [polypeptide binding]; other site
1198627005502	interdomain contacts; other site
1198627005503	partial ornithine binding site; other site
1198627005504	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1198627005505	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1198627005506	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1198627005507	catalytic site [active]
1198627005508	subunit interface [polypeptide binding]; other site
1198627005509	dihydroorotase; Validated; Region: pyrC; PRK09357
1198627005510	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627005511	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1198627005512	active site
1198627005513	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1198627005514	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1198627005515	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1198627005516	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1198627005517	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627005518	active site
1198627005519	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1198627005520	Beta-lactamase; Region: Beta-lactamase; pfam00144
1198627005521	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1198627005522	elongation factor P; Validated; Region: PRK00529
1198627005523	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1198627005524	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1198627005525	RNA binding site [nucleotide binding]; other site
1198627005526	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1198627005527	RNA binding site [nucleotide binding]; other site
1198627005528	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1198627005529	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1198627005530	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1198627005531	active site
1198627005532	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1198627005533	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1198627005534	trimer interface [polypeptide binding]; other site
1198627005535	active site
1198627005536	dimer interface [polypeptide binding]; other site
1198627005537	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1198627005538	active site
1198627005539	dimer interface [polypeptide binding]; other site
1198627005540	metal binding site [ion binding]; metal-binding site
1198627005541	shikimate kinase; Reviewed; Region: aroK; PRK00131
1198627005542	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1198627005543	ADP binding site [chemical binding]; other site
1198627005544	magnesium binding site [ion binding]; other site
1198627005545	putative shikimate binding site; other site
1198627005546	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1198627005547	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1198627005548	Tetramer interface [polypeptide binding]; other site
1198627005549	active site
1198627005550	FMN-binding site [chemical binding]; other site
1198627005551	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1198627005552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627005553	S-adenosylmethionine binding site [chemical binding]; other site
1198627005554	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1198627005555	YceG-like family; Region: YceG; pfam02618
1198627005556	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
1198627005557	dimerization interface [polypeptide binding]; other site
1198627005558	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1198627005559	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1198627005560	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1198627005561	motif 1; other site
1198627005562	active site
1198627005563	motif 2; other site
1198627005564	motif 3; other site
1198627005565	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1198627005566	DHHA1 domain; Region: DHHA1; pfam02272
1198627005567	recombination factor protein RarA; Reviewed; Region: PRK13342
1198627005568	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627005569	Walker A motif; other site
1198627005570	ATP binding site [chemical binding]; other site
1198627005571	Walker B motif; other site
1198627005572	arginine finger; other site
1198627005573	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1198627005574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1198627005575	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1198627005576	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1198627005577	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1198627005578	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1198627005579	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
1198627005580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1198627005581	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1198627005582	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1198627005583	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1198627005584	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627005585	motif II; other site
1198627005586	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1198627005587	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1198627005588	dimer interface [polypeptide binding]; other site
1198627005589	anticodon binding site; other site
1198627005590	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1198627005591	homodimer interface [polypeptide binding]; other site
1198627005592	motif 1; other site
1198627005593	active site
1198627005594	motif 2; other site
1198627005595	GAD domain; Region: GAD; pfam02938
1198627005596	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1198627005597	active site
1198627005598	motif 3; other site
1198627005599	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1198627005600	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627005601	substrate binding pocket [chemical binding]; other site
1198627005602	catalytic triad [active]
1198627005603	Predicted metalloprotease [General function prediction only]; Region: COG2321
1198627005604	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1198627005605	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627005606	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1198627005607	FeS/SAM binding site; other site
1198627005608	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
1198627005609	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1198627005610	dimer interface [polypeptide binding]; other site
1198627005611	motif 1; other site
1198627005612	active site
1198627005613	motif 2; other site
1198627005614	motif 3; other site
1198627005615	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1198627005616	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1198627005617	active site
1198627005618	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1198627005619	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
1198627005620	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1198627005621	Zn2+ binding site [ion binding]; other site
1198627005622	Mg2+ binding site [ion binding]; other site
1198627005623	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1198627005624	synthetase active site [active]
1198627005625	NTP binding site [chemical binding]; other site
1198627005626	metal binding site [ion binding]; metal-binding site
1198627005627	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1198627005628	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1198627005629	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627005630	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1198627005631	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1198627005632	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1198627005633	Protein export membrane protein; Region: SecD_SecF; pfam02355
1198627005634	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1198627005635	Protein export membrane protein; Region: SecD_SecF; cl14618
1198627005636	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
1198627005637	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1198627005638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627005639	Walker A motif; other site
1198627005640	ATP binding site [chemical binding]; other site
1198627005641	Walker B motif; other site
1198627005642	arginine finger; other site
1198627005643	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1198627005644	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1198627005645	RuvA N terminal domain; Region: RuvA_N; pfam01330
1198627005646	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1198627005647	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1198627005648	active site
1198627005649	putative DNA-binding cleft [nucleotide binding]; other site
1198627005650	dimer interface [polypeptide binding]; other site
1198627005651	hypothetical protein; Validated; Region: PRK00110
1198627005652	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1198627005653	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143
1198627005654	predicted active site [active]
1198627005655	catalytic triad [active]
1198627005656	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1198627005657	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1198627005658	active site
1198627005659	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1198627005660	catalytic triad [active]
1198627005661	dimer interface [polypeptide binding]; other site
1198627005662	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1198627005663	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1198627005664	active site
1198627005665	multimer interface [polypeptide binding]; other site
1198627005666	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1198627005667	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1198627005668	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1198627005669	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1198627005670	putative acyl-acceptor binding pocket; other site
1198627005671	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1198627005672	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1198627005673	nucleotide binding site/active site [active]
1198627005674	HIT family signature motif; other site
1198627005675	catalytic residue [active]
1198627005676	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1198627005677	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1198627005678	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1198627005679	active site
1198627005680	dimer interface [polypeptide binding]; other site
1198627005681	motif 1; other site
1198627005682	motif 2; other site
1198627005683	motif 3; other site
1198627005684	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1198627005685	anticodon binding site; other site
1198627005686	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1198627005687	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1198627005688	conserved cys residue [active]
1198627005689	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627005690	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627005691	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
1198627005692	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627005693	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1198627005694	homotrimer interaction site [polypeptide binding]; other site
1198627005695	putative active site [active]
1198627005696	hypothetical protein; Provisional; Region: PRK06208
1198627005697	intersubunit interface [polypeptide binding]; other site
1198627005698	active site
1198627005699	Zn2+ binding site [ion binding]; other site
1198627005700	L-asparagine permease; Provisional; Region: PRK15049
1198627005701	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
1198627005702	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
1198627005703	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1198627005704	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627005705	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1198627005706	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
1198627005707	putative active site [active]
1198627005708	catalytic triad [active]
1198627005709	putative dimer interface [polypeptide binding]; other site
1198627005710	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1198627005711	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1198627005712	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1198627005713	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1198627005714	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
1198627005715	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1198627005716	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1198627005717	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
1198627005718	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1198627005719	active site
1198627005720	putative substrate binding pocket [chemical binding]; other site
1198627005721	guanine deaminase; Provisional; Region: PRK09228
1198627005722	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627005723	active site
1198627005724	urate oxidase; Region: urate_oxi; TIGR03383
1198627005725	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1198627005726	active site
1198627005727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627005728	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1198627005729	DNA-binding site [nucleotide binding]; DNA binding site
1198627005730	FCD domain; Region: FCD; pfam07729
1198627005731	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1198627005732	Na binding site [ion binding]; other site
1198627005733	putative substrate binding site [chemical binding]; other site
1198627005734	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1198627005735	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1198627005736	allantoicase; Provisional; Region: PRK13257
1198627005737	Allantoicase repeat; Region: Allantoicase; pfam03561
1198627005738	Allantoicase repeat; Region: Allantoicase; pfam03561
1198627005739	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1198627005740	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1198627005741	active site
1198627005742	catalytic tetrad [active]
1198627005743	short chain dehydrogenase; Provisional; Region: PRK06181
1198627005744	classical (c) SDRs; Region: SDR_c; cd05233
1198627005745	NAD(P) binding site [chemical binding]; other site
1198627005746	active site
1198627005747	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627005748	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627005749	active site
1198627005750	short chain dehydrogenase; Provisional; Region: PRK07791
1198627005751	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627005752	NAD(P) binding site [chemical binding]; other site
1198627005753	active site
1198627005754	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1198627005755	hydrophobic ligand binding site; other site
1198627005756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627005757	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627005758	putative substrate translocation pore; other site
1198627005759	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1198627005760	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1198627005761	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627005762	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627005763	acyl-activating enzyme (AAE) consensus motif; other site
1198627005764	acyl-activating enzyme (AAE) consensus motif; other site
1198627005765	AMP binding site [chemical binding]; other site
1198627005766	active site
1198627005767	CoA binding site [chemical binding]; other site
1198627005768	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1198627005769	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627005770	NAD(P) binding site [chemical binding]; other site
1198627005771	active site
1198627005772	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1198627005773	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627005774	acyl-activating enzyme (AAE) consensus motif; other site
1198627005775	AMP binding site [chemical binding]; other site
1198627005776	active site
1198627005777	CoA binding site [chemical binding]; other site
1198627005778	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1198627005779	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1198627005780	putative NAD(P) binding site [chemical binding]; other site
1198627005781	active site
1198627005782	putative substrate binding site [chemical binding]; other site
1198627005783	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1198627005784	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627005785	active site
1198627005786	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627005787	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627005788	catalytic loop [active]
1198627005789	iron binding site [ion binding]; other site
1198627005790	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627005791	ABC1 family; Region: ABC1; pfam03109
1198627005792	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1198627005793	active site
1198627005794	ATP binding site [chemical binding]; other site
1198627005795	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1198627005796	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627005797	NAD(P) binding site [chemical binding]; other site
1198627005798	active site
1198627005799	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1198627005800	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
1198627005801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1198627005802	Walker A motif; other site
1198627005803	ATP binding site [chemical binding]; other site
1198627005804	Walker B motif; other site
1198627005805	TAP-like protein; Region: Abhydrolase_4; pfam08386
1198627005806	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1198627005807	SelR domain; Region: SelR; pfam01641
1198627005808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627005809	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1198627005810	putative substrate translocation pore; other site
1198627005811	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
1198627005812	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1198627005813	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1198627005814	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1198627005815	substrate binding site [chemical binding]; other site
1198627005816	active site
1198627005817	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1198627005818	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1198627005819	catalytic site [active]
1198627005820	putative active site [active]
1198627005821	putative substrate binding site [chemical binding]; other site
1198627005822	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1198627005823	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1198627005824	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1198627005825	TPP-binding site; other site
1198627005826	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1198627005827	PYR/PP interface [polypeptide binding]; other site
1198627005828	dimer interface [polypeptide binding]; other site
1198627005829	TPP binding site [chemical binding]; other site
1198627005830	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1198627005831	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
1198627005832	TRAM domain; Region: TRAM; pfam01938
1198627005833	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1198627005834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1198627005835	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1198627005836	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1198627005837	TrkA-N domain; Region: TrkA_N; pfam02254
1198627005838	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1198627005839	TrkA-N domain; Region: TrkA_N; pfam02254
1198627005840	TrkA-C domain; Region: TrkA_C; pfam02080
1198627005841	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1198627005842	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627005843	NAD(P) binding site [chemical binding]; other site
1198627005844	active site
1198627005845	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1198627005846	trimer interface [polypeptide binding]; other site
1198627005847	active site
1198627005848	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1198627005849	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1198627005850	active site
1198627005851	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1198627005852	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1198627005853	nucleotide binding site [chemical binding]; other site
1198627005854	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1198627005855	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627005856	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1198627005857	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627005858	DNA binding residues [nucleotide binding]
1198627005859	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1198627005860	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1198627005861	DNA binding site [nucleotide binding]
1198627005862	active site
1198627005863	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1198627005864	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
1198627005865	homotrimer interaction site [polypeptide binding]; other site
1198627005866	putative active site [active]
1198627005867	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1198627005868	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627005869	DNA-binding site [nucleotide binding]; DNA binding site
1198627005870	hypothetical protein; Provisional; Region: PRK05409
1198627005871	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1198627005872	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1198627005873	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1198627005874	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627005875	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1198627005876	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627005877	DNA binding residues [nucleotide binding]
1198627005878	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1198627005879	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1198627005880	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1198627005881	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1198627005882	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1198627005883	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627005884	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627005885	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1198627005886	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627005887	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1198627005888	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
1198627005889	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1198627005890	ATP cone domain; Region: ATP-cone; pfam03477
1198627005891	LexA repressor; Validated; Region: PRK00215
1198627005892	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1198627005893	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1198627005894	Catalytic site [active]
1198627005895	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627005896	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627005897	active site
1198627005898	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1198627005899	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1198627005900	molybdopterin cofactor binding site [chemical binding]; other site
1198627005901	substrate binding site [chemical binding]; other site
1198627005902	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1198627005903	molybdopterin cofactor binding site; other site
1198627005904	GTPases [General function prediction only]; Region: HflX; COG2262
1198627005905	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1198627005906	HflX GTPase family; Region: HflX; cd01878
1198627005907	G1 box; other site
1198627005908	GTP/Mg2+ binding site [chemical binding]; other site
1198627005909	Switch I region; other site
1198627005910	G2 box; other site
1198627005911	G3 box; other site
1198627005912	Switch II region; other site
1198627005913	G4 box; other site
1198627005914	G5 box; other site
1198627005915	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1198627005916	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1198627005917	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1198627005918	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1198627005919	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1198627005920	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1198627005921	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1198627005922	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627005923	FeS/SAM binding site; other site
1198627005924	Dehydratase family; Region: ILVD_EDD; cl00340
1198627005925	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1198627005926	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1198627005927	Walker A/P-loop; other site
1198627005928	ATP binding site [chemical binding]; other site
1198627005929	Q-loop/lid; other site
1198627005930	ABC transporter signature motif; other site
1198627005931	Walker B; other site
1198627005932	D-loop; other site
1198627005933	H-loop/switch region; other site
1198627005934	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1198627005935	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1198627005936	substrate binding pocket [chemical binding]; other site
1198627005937	membrane-bound complex binding site; other site
1198627005938	hinge residues; other site
1198627005939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627005940	dimer interface [polypeptide binding]; other site
1198627005941	conserved gate region; other site
1198627005942	putative PBP binding loops; other site
1198627005943	ABC-ATPase subunit interface; other site
1198627005944	recombinase A; Provisional; Region: recA; PRK09354
1198627005945	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1198627005946	hexamer interface [polypeptide binding]; other site
1198627005947	Walker A motif; other site
1198627005948	ATP binding site [chemical binding]; other site
1198627005949	Walker B motif; other site
1198627005950	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1198627005951	short chain dehydrogenase; Provisional; Region: PRK05854
1198627005952	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1198627005953	putative NAD(P) binding site [chemical binding]; other site
1198627005954	active site
1198627005955	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1198627005956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1198627005957	Coenzyme A binding pocket [chemical binding]; other site
1198627005958	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1198627005959	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1198627005960	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1198627005961	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1198627005962	classical (c) SDRs; Region: SDR_c; cd05233
1198627005963	NAD(P) binding site [chemical binding]; other site
1198627005964	active site
1198627005965	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627005966	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1198627005967	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1198627005968	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1198627005969	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1198627005970	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1198627005971	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1198627005972	dimer interface [polypeptide binding]; other site
1198627005973	active site
1198627005974	catalytic residue [active]
1198627005975	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1198627005976	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1198627005977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1198627005978	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1198627005979	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1198627005980	folate binding site [chemical binding]; other site
1198627005981	NADP+ binding site [chemical binding]; other site
1198627005982	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1198627005983	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1198627005984	dimerization interface [polypeptide binding]; other site
1198627005985	active site
1198627005986	acyltransferase PapA5; Provisional; Region: PRK09294
1198627005987	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1198627005988	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1198627005989	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1198627005990	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1198627005991	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1198627005992	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1198627005993	Carbonic anhydrase; Region: Pro_CA; smart00947
1198627005994	active site clefts [active]
1198627005995	zinc binding site [ion binding]; other site
1198627005996	dimer interface [polypeptide binding]; other site
1198627005997	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1198627005998	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1198627005999	AsnC family; Region: AsnC_trans_reg; pfam01037
1198627006000	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1198627006001	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1198627006002	hexamer interface [polypeptide binding]; other site
1198627006003	ligand binding site [chemical binding]; other site
1198627006004	putative active site [active]
1198627006005	NAD(P) binding site [chemical binding]; other site
1198627006006	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627006007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627006008	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1198627006009	classical (c) SDRs; Region: SDR_c; cd05233
1198627006010	NAD(P) binding site [chemical binding]; other site
1198627006011	active site
1198627006012	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1198627006013	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1198627006014	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1198627006015	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1198627006016	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1198627006017	oligomer interface [polypeptide binding]; other site
1198627006018	RNA binding site [nucleotide binding]; other site
1198627006019	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1198627006020	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1198627006021	RNase E interface [polypeptide binding]; other site
1198627006022	trimer interface [polypeptide binding]; other site
1198627006023	active site
1198627006024	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1198627006025	putative nucleic acid binding region [nucleotide binding]; other site
1198627006026	G-X-X-G motif; other site
1198627006027	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1198627006028	RNA binding site [nucleotide binding]; other site
1198627006029	domain interface; other site
1198627006030	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1198627006031	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1198627006032	active site
1198627006033	Riboflavin kinase; Region: Flavokinase; pfam01687
1198627006034	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1198627006035	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627006036	putative DNA binding site [nucleotide binding]; other site
1198627006037	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1198627006038	FeoA domain; Region: FeoA; pfam04023
1198627006039	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1198627006040	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1198627006041	RNA binding site [nucleotide binding]; other site
1198627006042	active site
1198627006043	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1198627006044	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627006045	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627006046	active site
1198627006047	enoyl-CoA hydratase; Provisional; Region: PRK06190
1198627006048	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627006049	substrate binding site [chemical binding]; other site
1198627006050	oxyanion hole (OAH) forming residues; other site
1198627006051	trimer interface [polypeptide binding]; other site
1198627006052	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1198627006053	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1198627006054	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1198627006055	putative efflux protein, MATE family; Region: matE; TIGR00797
1198627006056	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1198627006057	translation initiation factor IF-2; Region: IF-2; TIGR00487
1198627006058	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1198627006059	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1198627006060	G1 box; other site
1198627006061	putative GEF interaction site [polypeptide binding]; other site
1198627006062	GTP/Mg2+ binding site [chemical binding]; other site
1198627006063	Switch I region; other site
1198627006064	G2 box; other site
1198627006065	G3 box; other site
1198627006066	Switch II region; other site
1198627006067	G4 box; other site
1198627006068	G5 box; other site
1198627006069	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1198627006070	Translation-initiation factor 2; Region: IF-2; pfam11987
1198627006071	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1198627006072	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1198627006073	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1198627006074	FAD binding pocket [chemical binding]; other site
1198627006075	FAD binding motif [chemical binding]; other site
1198627006076	phosphate binding motif [ion binding]; other site
1198627006077	beta-alpha-beta structure motif; other site
1198627006078	NAD binding pocket [chemical binding]; other site
1198627006079	Rrf2 family protein; Region: rrf2_super; TIGR00738
1198627006080	Transcriptional regulator; Region: Rrf2; cl17282
1198627006081	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1198627006082	NusA N-terminal domain; Region: NusA_N; pfam08529
1198627006083	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1198627006084	RNA binding site [nucleotide binding]; other site
1198627006085	homodimer interface [polypeptide binding]; other site
1198627006086	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1198627006087	G-X-X-G motif; other site
1198627006088	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1198627006089	G-X-X-G motif; other site
1198627006090	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1198627006091	Sm and related proteins; Region: Sm_like; cl00259
1198627006092	heptamer interface [polypeptide binding]; other site
1198627006093	Sm1 motif; other site
1198627006094	hexamer interface [polypeptide binding]; other site
1198627006095	RNA binding site [nucleotide binding]; other site
1198627006096	Sm2 motif; other site
1198627006097	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1198627006098	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1198627006099	dimer interface [polypeptide binding]; other site
1198627006100	motif 1; other site
1198627006101	active site
1198627006102	motif 2; other site
1198627006103	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1198627006104	putative deacylase active site [active]
1198627006105	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1198627006106	active site
1198627006107	motif 3; other site
1198627006108	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1198627006109	anticodon binding site; other site
1198627006110	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1198627006111	siroheme synthase; Provisional; Region: cysG; PRK10637
1198627006112	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1198627006113	active site
1198627006114	SAM binding site [chemical binding]; other site
1198627006115	homodimer interface [polypeptide binding]; other site
1198627006116	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
1198627006117	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1198627006118	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1198627006119	Walker A/P-loop; other site
1198627006120	ATP binding site [chemical binding]; other site
1198627006121	Q-loop/lid; other site
1198627006122	ABC transporter signature motif; other site
1198627006123	Walker B; other site
1198627006124	D-loop; other site
1198627006125	H-loop/switch region; other site
1198627006126	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1198627006127	Walker A/P-loop; other site
1198627006128	ATP binding site [chemical binding]; other site
1198627006129	Q-loop/lid; other site
1198627006130	ABC transporter signature motif; other site
1198627006131	Walker B; other site
1198627006132	D-loop; other site
1198627006133	H-loop/switch region; other site
1198627006134	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1198627006135	Condensation domain; Region: Condensation; pfam00668
1198627006136	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1198627006137	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1198627006138	active site
1198627006139	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1198627006140	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1198627006141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627006142	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1198627006143	Enoylreductase; Region: PKS_ER; smart00829
1198627006144	NAD(P) binding site [chemical binding]; other site
1198627006145	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1198627006146	KR domain; Region: KR; pfam08659
1198627006147	putative NADP binding site [chemical binding]; other site
1198627006148	active site
1198627006149	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1198627006150	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627006151	Transport protein; Region: actII; TIGR00833
1198627006152	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627006153	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627006154	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1198627006155	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1198627006156	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1198627006157	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1198627006158	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
1198627006159	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
1198627006160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627006161	Walker A motif; other site
1198627006162	ATP binding site [chemical binding]; other site
1198627006163	Walker B motif; other site
1198627006164	arginine finger; other site
1198627006165	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1198627006166	metal ion-dependent adhesion site (MIDAS); other site
1198627006167	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1198627006168	malate:quinone oxidoreductase; Validated; Region: PRK05257
1198627006169	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1198627006170	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1198627006171	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1198627006172	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1198627006173	catalytic triad [active]
1198627006174	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1198627006175	active site
1198627006176	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1198627006177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1198627006178	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1198627006179	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1198627006180	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1198627006181	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1198627006182	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1198627006183	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1198627006184	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1198627006185	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1198627006186	active site
1198627006187	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1198627006188	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1198627006189	putative substrate binding region [chemical binding]; other site
1198627006190	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1198627006191	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1198627006192	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1198627006193	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1198627006194	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
1198627006195	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627006196	FeS/SAM binding site; other site
1198627006197	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1198627006198	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627006199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627006200	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1198627006201	dimerization interface [polypeptide binding]; other site
1198627006202	Dienelactone hydrolase family; Region: DLH; pfam01738
1198627006203	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1198627006204	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1198627006205	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1198627006206	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1198627006207	hinge region; other site
1198627006208	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1198627006209	putative nucleotide binding site [chemical binding]; other site
1198627006210	uridine monophosphate binding site [chemical binding]; other site
1198627006211	homohexameric interface [polypeptide binding]; other site
1198627006212	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1198627006213	Part of AAA domain; Region: AAA_19; pfam13245
1198627006214	Family description; Region: UvrD_C_2; pfam13538
1198627006215	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1198627006216	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1198627006217	beta-galactosidase; Region: BGL; TIGR03356
1198627006218	elongation factor Ts; Provisional; Region: tsf; PRK09377
1198627006219	UBA/TS-N domain; Region: UBA; pfam00627
1198627006220	Elongation factor TS; Region: EF_TS; pfam00889
1198627006221	Elongation factor TS; Region: EF_TS; pfam00889
1198627006222	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1198627006223	rRNA interaction site [nucleotide binding]; other site
1198627006224	S8 interaction site; other site
1198627006225	putative laminin-1 binding site; other site
1198627006226	Transport protein; Region: actII; TIGR00833
1198627006227	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1198627006228	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1198627006229	active site
1198627006230	DNA binding site [nucleotide binding]
1198627006231	Int/Topo IB signature motif; other site
1198627006232	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1198627006233	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1198627006234	FAD binding pocket [chemical binding]; other site
1198627006235	FAD binding motif [chemical binding]; other site
1198627006236	phosphate binding motif [ion binding]; other site
1198627006237	NAD binding pocket [chemical binding]; other site
1198627006238	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627006239	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627006240	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
1198627006241	putative dimerization interface [polypeptide binding]; other site
1198627006242	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1198627006243	active site clefts [active]
1198627006244	zinc binding site [ion binding]; other site
1198627006245	dimer interface [polypeptide binding]; other site
1198627006246	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1198627006247	DNA protecting protein DprA; Region: dprA; TIGR00732
1198627006248	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
1198627006249	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1198627006250	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1198627006251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627006252	Walker A motif; other site
1198627006253	ATP binding site [chemical binding]; other site
1198627006254	Walker B motif; other site
1198627006255	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1198627006256	hypothetical protein; Reviewed; Region: PRK12497
1198627006257	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1198627006258	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1198627006259	RNA/DNA hybrid binding site [nucleotide binding]; other site
1198627006260	active site
1198627006261	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1198627006262	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1198627006263	Catalytic site [active]
1198627006264	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1198627006265	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1198627006266	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1198627006267	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1198627006268	RimM N-terminal domain; Region: RimM; pfam01782
1198627006269	PRC-barrel domain; Region: PRC; pfam05239
1198627006270	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1198627006271	SnoaL-like domain; Region: SnoaL_4; pfam13577
1198627006272	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1198627006273	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1198627006274	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1198627006275	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1198627006276	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1198627006277	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1198627006278	active site
1198627006279	signal recognition particle protein; Provisional; Region: PRK10867
1198627006280	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1198627006281	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1198627006282	P loop; other site
1198627006283	GTP binding site [chemical binding]; other site
1198627006284	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1198627006285	PII uridylyl-transferase; Provisional; Region: PRK03381
1198627006286	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1198627006287	metal binding triad; other site
1198627006288	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1198627006289	HD domain; Region: HD; pfam01966
1198627006290	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
1198627006291	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1198627006292	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1198627006293	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1198627006294	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1198627006295	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
1198627006296	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1198627006297	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1198627006298	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1198627006299	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1198627006300	catalytic residues [active]
1198627006301	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1198627006302	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1198627006303	Walker A/P-loop; other site
1198627006304	ATP binding site [chemical binding]; other site
1198627006305	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1198627006306	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1198627006307	ABC transporter signature motif; other site
1198627006308	Walker B; other site
1198627006309	D-loop; other site
1198627006310	H-loop/switch region; other site
1198627006311	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1198627006312	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1198627006313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627006314	active site
1198627006315	phosphorylation site [posttranslational modification]
1198627006316	intermolecular recognition site; other site
1198627006317	dimerization interface [polypeptide binding]; other site
1198627006318	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627006319	DNA binding site [nucleotide binding]
1198627006320	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1198627006321	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1198627006322	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1198627006323	Ligand Binding Site [chemical binding]; other site
1198627006324	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1198627006325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627006326	phosphorylation site [posttranslational modification]
1198627006327	dimer interface [polypeptide binding]; other site
1198627006328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627006329	ATP binding site [chemical binding]; other site
1198627006330	Mg2+ binding site [ion binding]; other site
1198627006331	G-X-G motif; other site
1198627006332	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1198627006333	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1198627006334	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1198627006335	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1198627006336	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1198627006337	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1198627006338	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1198627006339	DNA binding site [nucleotide binding]
1198627006340	catalytic residue [active]
1198627006341	H2TH interface [polypeptide binding]; other site
1198627006342	putative catalytic residues [active]
1198627006343	turnover-facilitating residue; other site
1198627006344	intercalation triad [nucleotide binding]; other site
1198627006345	8OG recognition residue [nucleotide binding]; other site
1198627006346	putative reading head residues; other site
1198627006347	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1198627006348	ribonuclease III; Reviewed; Region: rnc; PRK00102
1198627006349	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1198627006350	dimerization interface [polypeptide binding]; other site
1198627006351	active site
1198627006352	metal binding site [ion binding]; metal-binding site
1198627006353	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1198627006354	dsRNA binding site [nucleotide binding]; other site
1198627006355	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1198627006356	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1198627006357	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1198627006358	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1198627006359	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1198627006360	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1198627006361	active site
1198627006362	(T/H)XGH motif; other site
1198627006363	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1198627006364	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1198627006365	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627006366	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1198627006367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627006368	S-adenosylmethionine binding site [chemical binding]; other site
1198627006369	pyruvate carboxylase; Reviewed; Region: PRK12999
1198627006370	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1198627006371	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1198627006372	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1198627006373	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1198627006374	active site
1198627006375	catalytic residues [active]
1198627006376	metal binding site [ion binding]; metal-binding site
1198627006377	homodimer binding site [polypeptide binding]; other site
1198627006378	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1198627006379	carboxyltransferase (CT) interaction site; other site
1198627006380	biotinylation site [posttranslational modification]; other site
1198627006381	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627006382	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627006383	substrate binding pocket [chemical binding]; other site
1198627006384	Cutinase; Region: Cutinase; pfam01083
1198627006385	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627006386	Cytochrome P450; Region: p450; cl12078
1198627006387	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1198627006388	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1198627006389	generic binding surface II; other site
1198627006390	ssDNA binding site; other site
1198627006391	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1198627006392	ATP binding site [chemical binding]; other site
1198627006393	putative Mg++ binding site [ion binding]; other site
1198627006394	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1198627006395	nucleotide binding region [chemical binding]; other site
1198627006396	ATP-binding site [chemical binding]; other site
1198627006397	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1198627006398	DAK2 domain; Region: Dak2; pfam02734
1198627006399	enoyl-CoA hydratase; Provisional; Region: PRK06688
1198627006400	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627006401	trimer interface [polypeptide binding]; other site
1198627006402	Secretory lipase; Region: LIP; pfam03583
1198627006403	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1198627006404	ligand binding site [chemical binding]; other site
1198627006405	active site
1198627006406	UGI interface [polypeptide binding]; other site
1198627006407	catalytic site [active]
1198627006408	thiamine monophosphate kinase; Provisional; Region: PRK05731
1198627006409	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1198627006410	ATP binding site [chemical binding]; other site
1198627006411	dimerization interface [polypeptide binding]; other site
1198627006412	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1198627006413	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1198627006414	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1198627006415	cystathionine gamma-lyase; Validated; Region: PRK07582
1198627006416	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627006417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627006418	catalytic residue [active]
1198627006419	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1198627006420	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1198627006421	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1198627006422	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
1198627006423	polyphosphate kinase; Provisional; Region: PRK05443
1198627006424	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1198627006425	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1198627006426	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1198627006427	putative domain interface [polypeptide binding]; other site
1198627006428	putative active site [active]
1198627006429	catalytic site [active]
1198627006430	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1198627006431	putative domain interface [polypeptide binding]; other site
1198627006432	putative active site [active]
1198627006433	catalytic site [active]
1198627006434	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1198627006435	active site
1198627006436	Ap6A binding site [chemical binding]; other site
1198627006437	nudix motif; other site
1198627006438	metal binding site [ion binding]; metal-binding site
1198627006439	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627006440	catalytic core [active]
1198627006441	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1198627006442	IHF - DNA interface [nucleotide binding]; other site
1198627006443	IHF dimer interface [polypeptide binding]; other site
1198627006444	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1198627006445	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1198627006446	substrate binding site [chemical binding]; other site
1198627006447	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1198627006448	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1198627006449	substrate binding site [chemical binding]; other site
1198627006450	ligand binding site [chemical binding]; other site
1198627006451	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1198627006452	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1198627006453	Bacterial transcriptional regulator; Region: IclR; pfam01614
1198627006454	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1198627006455	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1198627006456	HIGH motif; other site
1198627006457	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1198627006458	active site
1198627006459	KMSKS motif; other site
1198627006460	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627006461	putative substrate translocation pore; other site
1198627006462	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627006463	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1198627006464	tartrate dehydrogenase; Region: TTC; TIGR02089
1198627006465	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1198627006466	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1198627006467	ligand binding site [chemical binding]; other site
1198627006468	NAD binding site [chemical binding]; other site
1198627006469	dimerization interface [polypeptide binding]; other site
1198627006470	catalytic site [active]
1198627006471	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1198627006472	putative L-serine binding site [chemical binding]; other site
1198627006473	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1198627006474	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1198627006475	putative NAD(P) binding site [chemical binding]; other site
1198627006476	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627006477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627006478	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
1198627006479	putative dimerization interface [polypeptide binding]; other site
1198627006480	Protein of unknown function, DUF417; Region: DUF417; cl01162
1198627006481	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1198627006482	dimer interface [polypeptide binding]; other site
1198627006483	FMN binding site [chemical binding]; other site
1198627006484	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627006485	ABC1 family; Region: ABC1; pfam03109
1198627006486	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627006487	ABC1 family; Region: ABC1; pfam03109
1198627006488	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627006489	Cytochrome P450; Region: p450; cl12078
1198627006490	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1198627006491	Condensation domain; Region: Condensation; pfam00668
1198627006492	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627006493	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1198627006494	acyl-activating enzyme (AAE) consensus motif; other site
1198627006495	AMP binding site [chemical binding]; other site
1198627006496	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627006497	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1198627006498	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1198627006499	putative NAD(P) binding site [chemical binding]; other site
1198627006500	active site
1198627006501	putative substrate binding site [chemical binding]; other site
1198627006502	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1198627006503	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1198627006504	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1198627006505	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1198627006506	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1198627006507	putative valine binding site [chemical binding]; other site
1198627006508	dimer interface [polypeptide binding]; other site
1198627006509	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1198627006510	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
1198627006511	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1198627006512	PYR/PP interface [polypeptide binding]; other site
1198627006513	dimer interface [polypeptide binding]; other site
1198627006514	TPP binding site [chemical binding]; other site
1198627006515	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1198627006516	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1198627006517	TPP-binding site [chemical binding]; other site
1198627006518	dimer interface [polypeptide binding]; other site
1198627006519	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1198627006520	hypothetical protein; Provisional; Region: PRK06541
1198627006521	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627006522	inhibitor-cofactor binding pocket; inhibition site
1198627006523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627006524	catalytic residue [active]
1198627006525	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1198627006526	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1198627006527	AsnC family; Region: AsnC_trans_reg; pfam01037
1198627006528	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1198627006529	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1198627006530	NAD(P) binding site [chemical binding]; other site
1198627006531	catalytic residues [active]
1198627006532	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1198627006533	MarR family; Region: MarR_2; cl17246
1198627006534	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1198627006535	FAD binding domain; Region: FAD_binding_3; pfam01494
1198627006536	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1198627006537	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1198627006538	GatB domain; Region: GatB_Yqey; smart00845
1198627006539	6-phosphofructokinase; Provisional; Region: PRK03202
1198627006540	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1198627006541	active site
1198627006542	ADP/pyrophosphate binding site [chemical binding]; other site
1198627006543	dimerization interface [polypeptide binding]; other site
1198627006544	allosteric effector site; other site
1198627006545	fructose-1,6-bisphosphate binding site; other site
1198627006546	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1198627006547	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627006548	substrate binding pocket [chemical binding]; other site
1198627006549	catalytic triad [active]
1198627006550	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627006551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627006552	active site
1198627006553	phosphorylation site [posttranslational modification]
1198627006554	intermolecular recognition site; other site
1198627006555	dimerization interface [polypeptide binding]; other site
1198627006556	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627006557	DNA binding site [nucleotide binding]
1198627006558	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1198627006559	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1198627006560	dimerization interface [polypeptide binding]; other site
1198627006561	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627006562	dimer interface [polypeptide binding]; other site
1198627006563	phosphorylation site [posttranslational modification]
1198627006564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627006565	ATP binding site [chemical binding]; other site
1198627006566	Mg2+ binding site [ion binding]; other site
1198627006567	G-X-G motif; other site
1198627006568	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1198627006569	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1198627006570	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1198627006571	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1198627006572	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1198627006573	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1198627006574	nucleotide binding pocket [chemical binding]; other site
1198627006575	K-X-D-G motif; other site
1198627006576	catalytic site [active]
1198627006577	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1198627006578	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1198627006579	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1198627006580	Dimer interface [polypeptide binding]; other site
1198627006581	BRCT sequence motif; other site
1198627006582	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1198627006583	enoyl-CoA hydratase; Provisional; Region: PRK06142
1198627006584	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627006585	substrate binding site [chemical binding]; other site
1198627006586	oxyanion hole (OAH) forming residues; other site
1198627006587	trimer interface [polypeptide binding]; other site
1198627006588	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1198627006589	putative FMN binding site [chemical binding]; other site
1198627006590	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1198627006591	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1198627006592	homodimer interface [polypeptide binding]; other site
1198627006593	putative substrate binding pocket [chemical binding]; other site
1198627006594	diiron center [ion binding]; other site
1198627006595	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
1198627006596	active site
1198627006597	catalytic triad [active]
1198627006598	oxyanion hole [active]
1198627006599	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1198627006600	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1198627006601	Ligand Binding Site [chemical binding]; other site
1198627006602	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1198627006603	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1198627006604	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627006605	catalytic residue [active]
1198627006606	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1198627006607	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1198627006608	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1198627006609	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1198627006610	Ligand binding site [chemical binding]; other site
1198627006611	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1198627006612	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1198627006613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627006614	S-adenosylmethionine binding site [chemical binding]; other site
1198627006615	Uncharacterized conserved protein [Function unknown]; Region: COG1543
1198627006616	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1198627006617	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
1198627006618	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1198627006619	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1198627006620	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1198627006621	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627006622	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627006623	acyl-activating enzyme (AAE) consensus motif; other site
1198627006624	acyl-activating enzyme (AAE) consensus motif; other site
1198627006625	AMP binding site [chemical binding]; other site
1198627006626	active site
1198627006627	CoA binding site [chemical binding]; other site
1198627006628	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1198627006629	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1198627006630	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1198627006631	putative NAD(P) binding site [chemical binding]; other site
1198627006632	active site
1198627006633	putative substrate binding site [chemical binding]; other site
1198627006634	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1198627006635	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627006636	putative DNA binding site [nucleotide binding]; other site
1198627006637	putative Zn2+ binding site [ion binding]; other site
1198627006638	AsnC family; Region: AsnC_trans_reg; pfam01037
1198627006639	AzlC protein; Region: AzlC; cl00570
1198627006640	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1198627006641	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1198627006642	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1198627006643	trimer interface [polypeptide binding]; other site
1198627006644	active site
1198627006645	substrate binding site [chemical binding]; other site
1198627006646	CoA binding site [chemical binding]; other site
1198627006647	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1198627006648	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627006649	substrate binding site [chemical binding]; other site
1198627006650	oxyanion hole (OAH) forming residues; other site
1198627006651	trimer interface [polypeptide binding]; other site
1198627006652	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1198627006653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627006654	Walker A/P-loop; other site
1198627006655	ATP binding site [chemical binding]; other site
1198627006656	Q-loop/lid; other site
1198627006657	ABC transporter signature motif; other site
1198627006658	Walker B; other site
1198627006659	D-loop; other site
1198627006660	H-loop/switch region; other site
1198627006661	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1198627006662	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1198627006663	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1198627006664	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627006665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627006666	homodimer interface [polypeptide binding]; other site
1198627006667	catalytic residue [active]
1198627006668	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1198627006669	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1198627006670	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1198627006671	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627006672	motif II; other site
1198627006673	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1198627006674	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1198627006675	D-pathway; other site
1198627006676	Putative ubiquinol binding site [chemical binding]; other site
1198627006677	Low-spin heme (heme b) binding site [chemical binding]; other site
1198627006678	Putative water exit pathway; other site
1198627006679	Binuclear center (heme o3/CuB) [ion binding]; other site
1198627006680	K-pathway; other site
1198627006681	Putative proton exit pathway; other site
1198627006682	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1198627006683	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1198627006684	siderophore binding site; other site
1198627006685	Domain of unknown function (DUF385); Region: DUF385; cl04387
1198627006686	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1198627006687	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1198627006688	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1198627006689	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1198627006690	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1198627006691	putative NAD(P) binding site [chemical binding]; other site
1198627006692	putative substrate binding site [chemical binding]; other site
1198627006693	catalytic Zn binding site [ion binding]; other site
1198627006694	structural Zn binding site [ion binding]; other site
1198627006695	dimer interface [polypeptide binding]; other site
1198627006696	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627006697	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1198627006698	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1198627006699	dimer interface [polypeptide binding]; other site
1198627006700	putative radical transfer pathway; other site
1198627006701	diiron center [ion binding]; other site
1198627006702	tyrosyl radical; other site
1198627006703	short chain dehydrogenase; Provisional; Region: PRK07825
1198627006704	classical (c) SDRs; Region: SDR_c; cd05233
1198627006705	NAD(P) binding site [chemical binding]; other site
1198627006706	active site
1198627006707	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1198627006708	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1198627006709	dimerization interface [polypeptide binding]; other site
1198627006710	substrate binding pocket [chemical binding]; other site
1198627006711	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1198627006712	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1198627006713	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1198627006714	active site
1198627006715	dimer interface [polypeptide binding]; other site
1198627006716	catalytic residues [active]
1198627006717	effector binding site; other site
1198627006718	R2 peptide binding site; other site
1198627006719	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1198627006720	metabolite-proton symporter; Region: 2A0106; TIGR00883
1198627006721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627006722	putative substrate translocation pore; other site
1198627006723	Predicted flavoprotein [General function prediction only]; Region: COG0431
1198627006724	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1198627006725	short chain dehydrogenase; Provisional; Region: PRK07832
1198627006726	classical (c) SDRs; Region: SDR_c; cd05233
1198627006727	NAD(P) binding site [chemical binding]; other site
1198627006728	active site
1198627006729	Cytochrome P450; Region: p450; cl12078
1198627006730	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627006731	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1198627006732	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1198627006733	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1198627006734	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1198627006735	short chain dehydrogenase; Provisional; Region: PRK12744
1198627006736	NADP binding site [chemical binding]; other site
1198627006737	homodimer interface [polypeptide binding]; other site
1198627006738	active site
1198627006739	substrate binding site [chemical binding]; other site
1198627006740	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627006741	NAD(P) binding site [chemical binding]; other site
1198627006742	active site
1198627006743	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1198627006744	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
1198627006745	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627006746	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627006747	DNA binding residues [nucleotide binding]
1198627006748	Putative zinc-finger; Region: zf-HC2; pfam13490
1198627006749	Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039
1198627006750	Isochorismatase family; Region: Isochorismatase; pfam00857
1198627006751	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1198627006752	catalytic triad [active]
1198627006753	conserved cis-peptide bond; other site
1198627006754	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1198627006755	Na binding site [ion binding]; other site
1198627006756	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
1198627006757	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627006758	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
1198627006759	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1198627006760	acyl-activating enzyme (AAE) consensus motif; other site
1198627006761	putative AMP binding site [chemical binding]; other site
1198627006762	putative active site [active]
1198627006763	acyl-activating enzyme (AAE) consensus motif; other site
1198627006764	putative CoA binding site [chemical binding]; other site
1198627006765	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1198627006766	short chain dehydrogenase; Provisional; Region: PRK06197
1198627006767	putative NAD(P) binding site [chemical binding]; other site
1198627006768	active site
1198627006769	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627006770	NAD(P) binding site [chemical binding]; other site
1198627006771	active site
1198627006772	NAD-dependent deacetylase; Provisional; Region: PRK00481
1198627006773	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1198627006774	NAD+ binding site [chemical binding]; other site
1198627006775	substrate binding site [chemical binding]; other site
1198627006776	Zn binding site [ion binding]; other site
1198627006777	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1198627006778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627006779	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627006780	putative substrate translocation pore; other site
1198627006781	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627006782	phosphoglucomutase; Validated; Region: PRK07564
1198627006783	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1198627006784	active site
1198627006785	substrate binding site [chemical binding]; other site
1198627006786	metal binding site [ion binding]; metal-binding site
1198627006787	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1198627006788	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627006789	substrate binding pocket [chemical binding]; other site
1198627006790	catalytic triad [active]
1198627006791	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1198627006792	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627006793	substrate binding pocket [chemical binding]; other site
1198627006794	catalytic triad [active]
1198627006795	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
1198627006796	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627006797	dimer interface [polypeptide binding]; other site
1198627006798	active site
1198627006799	Predicted transcriptional regulators [Transcription]; Region: COG1733
1198627006800	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1198627006801	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
1198627006802	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627006803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627006804	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1198627006805	putative dimerization interface [polypeptide binding]; other site
1198627006806	Domain of unknown function (DUF385); Region: DUF385; cl04387
1198627006807	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627006808	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627006809	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1198627006810	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1198627006811	putative dimer interface [polypeptide binding]; other site
1198627006812	acetolactate synthase; Reviewed; Region: PRK08322
1198627006813	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1198627006814	PYR/PP interface [polypeptide binding]; other site
1198627006815	dimer interface [polypeptide binding]; other site
1198627006816	TPP binding site [chemical binding]; other site
1198627006817	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1198627006818	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1198627006819	TPP-binding site [chemical binding]; other site
1198627006820	dimer interface [polypeptide binding]; other site
1198627006821	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1198627006822	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627006823	NAD(P) binding site [chemical binding]; other site
1198627006824	catalytic residues [active]
1198627006825	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1198627006826	SmpB-tmRNA interface; other site
1198627006827	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1198627006828	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1198627006829	FtsX-like permease family; Region: FtsX; pfam02687
1198627006830	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1198627006831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627006832	Walker A/P-loop; other site
1198627006833	ATP binding site [chemical binding]; other site
1198627006834	Q-loop/lid; other site
1198627006835	ABC transporter signature motif; other site
1198627006836	Walker B; other site
1198627006837	D-loop; other site
1198627006838	H-loop/switch region; other site
1198627006839	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1198627006840	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1198627006841	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1198627006842	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1198627006843	RF-1 domain; Region: RF-1; pfam00472
1198627006844	ferredoxin-NADP+ reductase; Region: PLN02852
1198627006845	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627006846	hypothetical protein; Provisional; Region: PRK06834
1198627006847	hypothetical protein; Provisional; Region: PRK07236
1198627006848	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1198627006849	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1198627006850	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1198627006851	active site
1198627006852	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627006853	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627006854	active site
1198627006855	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627006856	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627006857	active site
1198627006858	acyl-CoA synthetase; Validated; Region: PRK07788
1198627006859	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627006860	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627006861	AMP binding site [chemical binding]; other site
1198627006862	active site
1198627006863	acyl-activating enzyme (AAE) consensus motif; other site
1198627006864	CoA binding site [chemical binding]; other site
1198627006865	Clp protease ATP binding subunit; Region: clpC; CHL00095
1198627006866	hypothetical protein; Validated; Region: PRK00068
1198627006867	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1198627006868	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1198627006869	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1198627006870	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1198627006871	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1198627006872	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627006873	ABC1 family; Region: ABC1; pfam03109
1198627006874	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1198627006875	active site
1198627006876	ATP binding site [chemical binding]; other site
1198627006877	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627006878	ABC1 family; Region: ABC1; pfam03109
1198627006879	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1198627006880	active site
1198627006881	ATP binding site [chemical binding]; other site
1198627006882	short chain dehydrogenase; Provisional; Region: PRK09291
1198627006883	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1198627006884	NADP binding site [chemical binding]; other site
1198627006885	active site
1198627006886	steroid binding site; other site
1198627006887	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627006888	ABC1 family; Region: ABC1; pfam03109
1198627006889	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1198627006890	active site
1198627006891	ATP binding site [chemical binding]; other site
1198627006892	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1198627006893	activation loop (A-loop); other site
1198627006894	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1198627006895	Part of AAA domain; Region: AAA_19; pfam13245
1198627006896	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1198627006897	Family description; Region: UvrD_C_2; pfam13538
1198627006898	HRDC domain; Region: HRDC; pfam00570
1198627006899	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1198627006900	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1198627006901	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1198627006902	putative NADH binding site [chemical binding]; other site
1198627006903	putative active site [active]
1198627006904	nudix motif; other site
1198627006905	putative metal binding site [ion binding]; other site
1198627006906	Ion channel; Region: Ion_trans_2; pfam07885
1198627006907	TrkA-N domain; Region: TrkA_N; pfam02254
1198627006908	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1198627006909	Part of AAA domain; Region: AAA_19; pfam13245
1198627006910	Family description; Region: UvrD_C_2; pfam13538
1198627006911	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1198627006912	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
1198627006913	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1198627006914	active site
1198627006915	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627006916	DNA binding site [nucleotide binding]
1198627006917	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1198627006918	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1198627006919	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1198627006920	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1198627006921	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1198627006922	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
1198627006923	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1198627006924	ATP binding site [chemical binding]; other site
1198627006925	substrate interface [chemical binding]; other site
1198627006926	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1198627006927	active site residue [active]
1198627006928	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1198627006929	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1198627006930	ATP binding site [chemical binding]; other site
1198627006931	Mg++ binding site [ion binding]; other site
1198627006932	motif III; other site
1198627006933	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1198627006934	nucleotide binding region [chemical binding]; other site
1198627006935	ATP-binding site [chemical binding]; other site
1198627006936	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1198627006937	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1198627006938	P-loop; other site
1198627006939	Magnesium ion binding site [ion binding]; other site
1198627006940	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1198627006941	Magnesium ion binding site [ion binding]; other site
1198627006942	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627006943	catalytic core [active]
1198627006944	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1198627006945	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1198627006946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1198627006947	Histidine kinase; Region: HisKA_2; pfam07568
1198627006948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627006949	ATP binding site [chemical binding]; other site
1198627006950	Mg2+ binding site [ion binding]; other site
1198627006951	G-X-G motif; other site
1198627006952	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1198627006953	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627006954	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627006955	DNA binding residues [nucleotide binding]
1198627006956	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1198627006957	putative deacylase active site [active]
1198627006958	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1198627006959	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1198627006960	hinge; other site
1198627006961	active site
1198627006962	Predicted GTPases [General function prediction only]; Region: COG1162
1198627006963	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1198627006964	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1198627006965	GTP/Mg2+ binding site [chemical binding]; other site
1198627006966	G4 box; other site
1198627006967	G5 box; other site
1198627006968	G1 box; other site
1198627006969	Switch I region; other site
1198627006970	G2 box; other site
1198627006971	G3 box; other site
1198627006972	Switch II region; other site
1198627006973	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1198627006974	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1198627006975	putative di-iron ligands [ion binding]; other site
1198627006976	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1198627006977	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1198627006978	FAD binding pocket [chemical binding]; other site
1198627006979	FAD binding motif [chemical binding]; other site
1198627006980	phosphate binding motif [ion binding]; other site
1198627006981	beta-alpha-beta structure motif; other site
1198627006982	NAD binding pocket [chemical binding]; other site
1198627006983	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627006984	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1198627006985	catalytic loop [active]
1198627006986	iron binding site [ion binding]; other site
1198627006987	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1198627006988	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1198627006989	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1198627006990	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1198627006991	active site
1198627006992	catalytic residues [active]
1198627006993	metal binding site [ion binding]; metal-binding site
1198627006994	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1198627006995	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1198627006996	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1198627006997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627006998	putative substrate translocation pore; other site
1198627006999	Transport protein; Region: actII; TIGR00833
1198627007000	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627007001	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1198627007002	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627007003	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627007004	Thioesterase domain; Region: Thioesterase; pfam00975
1198627007005	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
1198627007006	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1198627007007	active site
1198627007008	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1198627007009	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1198627007010	active site
1198627007011	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1198627007012	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1198627007013	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627007014	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1198627007015	active site
1198627007016	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627007017	acyl-CoA synthetase; Validated; Region: PRK05850
1198627007018	acyl-activating enzyme (AAE) consensus motif; other site
1198627007019	active site
1198627007020	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1198627007021	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1198627007022	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1198627007023	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627007024	DNA-binding site [nucleotide binding]; DNA binding site
1198627007025	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627007026	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627007027	homodimer interface [polypeptide binding]; other site
1198627007028	catalytic residue [active]
1198627007029	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1198627007030	30S subunit binding site; other site
1198627007031	lipoprotein LpqB; Provisional; Region: PRK13616
1198627007032	Sporulation and spore germination; Region: Germane; pfam10646
1198627007033	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1198627007034	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1198627007035	dimerization interface [polypeptide binding]; other site
1198627007036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627007037	dimer interface [polypeptide binding]; other site
1198627007038	phosphorylation site [posttranslational modification]
1198627007039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627007040	ATP binding site [chemical binding]; other site
1198627007041	Mg2+ binding site [ion binding]; other site
1198627007042	G-X-G motif; other site
1198627007043	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627007044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627007045	active site
1198627007046	phosphorylation site [posttranslational modification]
1198627007047	intermolecular recognition site; other site
1198627007048	dimerization interface [polypeptide binding]; other site
1198627007049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627007050	DNA binding site [nucleotide binding]
1198627007051	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627007052	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1198627007053	acyl-activating enzyme (AAE) consensus motif; other site
1198627007054	AMP binding site [chemical binding]; other site
1198627007055	active site
1198627007056	CoA binding site [chemical binding]; other site
1198627007057	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1198627007058	MgtC family; Region: MgtC; pfam02308
1198627007059	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1198627007060	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1198627007061	TMP-binding site; other site
1198627007062	ATP-binding site [chemical binding]; other site
1198627007063	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1198627007064	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1198627007065	homotetramer interface [polypeptide binding]; other site
1198627007066	ligand binding site [chemical binding]; other site
1198627007067	catalytic site [active]
1198627007068	NAD binding site [chemical binding]; other site
1198627007069	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1198627007070	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1198627007071	Di-iron ligands [ion binding]; other site
1198627007072	amino acid transporter; Region: 2A0306; TIGR00909
1198627007073	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1198627007074	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1198627007075	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1198627007076	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1198627007077	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1198627007078	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1198627007079	active site
1198627007080	substrate binding site [chemical binding]; other site
1198627007081	metal binding site [ion binding]; metal-binding site
1198627007082	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
1198627007083	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
1198627007084	dimer interface [polypeptide binding]; other site
1198627007085	substrate binding site [chemical binding]; other site
1198627007086	phosphate binding site [ion binding]; other site
1198627007087	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
1198627007088	F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916
1198627007089	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
1198627007090	putative FMN binding site [chemical binding]; other site
1198627007091	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1198627007092	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1198627007093	active site
1198627007094	Substrate binding site; other site
1198627007095	Mg++ binding site; other site
1198627007096	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1198627007097	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1198627007098	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1198627007099	Probable Catalytic site; other site
1198627007100	metal-binding site
1198627007101	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1198627007102	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1198627007103	NADP binding site [chemical binding]; other site
1198627007104	active site
1198627007105	putative substrate binding site [chemical binding]; other site
1198627007106	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1198627007107	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1198627007108	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1198627007109	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1198627007110	putative active site [active]
1198627007111	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627007112	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1198627007113	FAD binding site [chemical binding]; other site
1198627007114	homotetramer interface [polypeptide binding]; other site
1198627007115	substrate binding pocket [chemical binding]; other site
1198627007116	catalytic base [active]
1198627007117	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1198627007118	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1198627007119	ATP-grasp domain; Region: ATP-grasp; pfam02222
1198627007120	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1198627007121	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1198627007122	active site
1198627007123	iron coordination sites [ion binding]; other site
1198627007124	substrate binding pocket [chemical binding]; other site
1198627007125	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1198627007126	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1198627007127	NADP binding site [chemical binding]; other site
1198627007128	dimer interface [polypeptide binding]; other site
1198627007129	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1198627007130	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1198627007131	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1198627007132	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1198627007133	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
1198627007134	acyl-CoA synthetase; Provisional; Region: PRK13388
1198627007135	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627007136	acyl-activating enzyme (AAE) consensus motif; other site
1198627007137	AMP binding site [chemical binding]; other site
1198627007138	active site
1198627007139	CoA binding site [chemical binding]; other site
1198627007140	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1198627007141	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1198627007142	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1198627007143	Maf-like protein; Region: Maf; pfam02545
1198627007144	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1198627007145	active site
1198627007146	dimer interface [polypeptide binding]; other site
1198627007147	GntP family permease; Region: GntP_permease; pfam02447
1198627007148	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1198627007149	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1198627007150	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627007151	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1198627007152	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1198627007153	active site
1198627007154	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1198627007155	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627007156	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1198627007157	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1198627007158	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1198627007159	active site residue [active]
1198627007160	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1198627007161	active site residue [active]
1198627007162	Fe-S metabolism associated domain; Region: SufE; cl00951
1198627007163	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
1198627007164	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1198627007165	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1198627007166	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1198627007167	L-lysine aminotransferase; Provisional; Region: PRK08297
1198627007168	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627007169	inhibitor-cofactor binding pocket; inhibition site
1198627007170	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627007171	catalytic residue [active]
1198627007172	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1198627007173	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1198627007174	AsnC family; Region: AsnC_trans_reg; pfam01037
1198627007175	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1198627007176	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1198627007177	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627007178	tetrameric interface [polypeptide binding]; other site
1198627007179	NAD binding site [chemical binding]; other site
1198627007180	catalytic residues [active]
1198627007181	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1198627007182	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1198627007183	ATP binding site [chemical binding]; other site
1198627007184	putative Mg++ binding site [ion binding]; other site
1198627007185	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1198627007186	nucleotide binding region [chemical binding]; other site
1198627007187	ATP-binding site [chemical binding]; other site
1198627007188	DEAD/H associated; Region: DEAD_assoc; pfam08494
1198627007189	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1198627007190	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
1198627007191	probable active site [active]
1198627007192	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1198627007193	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1198627007194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627007195	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627007196	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1198627007197	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1198627007198	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
1198627007199	metal binding site [ion binding]; metal-binding site
1198627007200	putative dimer interface [polypeptide binding]; other site
1198627007201	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1198627007202	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1198627007203	metal binding site [ion binding]; metal-binding site
1198627007204	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1198627007205	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1198627007206	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1198627007207	active site
1198627007208	substrate binding site [chemical binding]; other site
1198627007209	metal binding site [ion binding]; metal-binding site
1198627007210	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627007211	active site
1198627007212	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1198627007213	NlpC/P60 family; Region: NLPC_P60; pfam00877
1198627007214	adenosine deaminase; Provisional; Region: PRK09358
1198627007215	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1198627007216	active site
1198627007217	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1198627007218	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1198627007219	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1198627007220	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1198627007221	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1198627007222	active site
1198627007223	catalytic motif [active]
1198627007224	Zn binding site [ion binding]; other site
1198627007225	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
1198627007226	L-aspartate oxidase; Provisional; Region: PRK06175
1198627007227	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1198627007228	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1198627007229	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1198627007230	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1198627007231	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1198627007232	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1198627007233	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1198627007234	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1198627007235	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1198627007236	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1198627007237	active site
1198627007238	HIGH motif; other site
1198627007239	dimer interface [polypeptide binding]; other site
1198627007240	KMSKS motif; other site
1198627007241	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1198627007242	putative active site [active]
1198627007243	putative catalytic site [active]
1198627007244	putative DNA binding site [nucleotide binding]; other site
1198627007245	putative phosphate binding site [ion binding]; other site
1198627007246	metal binding site A [ion binding]; metal-binding site
1198627007247	putative AP binding site [nucleotide binding]; other site
1198627007248	putative metal binding site B [ion binding]; other site
1198627007249	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1198627007250	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1198627007251	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
1198627007252	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1198627007253	homodimer interface [polypeptide binding]; other site
1198627007254	substrate-cofactor binding pocket; other site
1198627007255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627007256	catalytic residue [active]
1198627007257	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1198627007258	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1198627007259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627007260	S-adenosylmethionine binding site [chemical binding]; other site
1198627007261	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1198627007262	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1198627007263	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1198627007264	homodimer interface [polypeptide binding]; other site
1198627007265	NADP binding site [chemical binding]; other site
1198627007266	substrate binding site [chemical binding]; other site
1198627007267	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1198627007268	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1198627007269	active site
1198627007270	FMN binding site [chemical binding]; other site
1198627007271	substrate binding site [chemical binding]; other site
1198627007272	putative catalytic residue [active]
1198627007273	Predicted transcriptional regulators [Transcription]; Region: COG1733
1198627007274	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1198627007275	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1198627007276	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1198627007277	NAD binding site [chemical binding]; other site
1198627007278	substrate binding site [chemical binding]; other site
1198627007279	putative active site [active]
1198627007280	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1198627007281	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1198627007282	phosphopeptide binding site; other site
1198627007283	YppG-like protein; Region: YppG; pfam14179
1198627007284	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1198627007285	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1198627007286	phosphopeptide binding site; other site
1198627007287	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
1198627007288	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1198627007289	Walker A/P-loop; other site
1198627007290	ATP binding site [chemical binding]; other site
1198627007291	Q-loop/lid; other site
1198627007292	ABC transporter signature motif; other site
1198627007293	Walker B; other site
1198627007294	D-loop; other site
1198627007295	H-loop/switch region; other site
1198627007296	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1198627007297	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1198627007298	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1198627007299	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1198627007300	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1198627007301	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1198627007302	generic binding surface II; other site
1198627007303	generic binding surface I; other site
1198627007304	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1198627007305	short chain dehydrogenase; Provisional; Region: PRK07201
1198627007306	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
1198627007307	putative NAD(P) binding site [chemical binding]; other site
1198627007308	active site
1198627007309	putative substrate binding site [chemical binding]; other site
1198627007310	classical (c) SDRs; Region: SDR_c; cd05233
1198627007311	NAD(P) binding site [chemical binding]; other site
1198627007312	active site
1198627007313	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1198627007314	active site
1198627007315	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1198627007316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627007317	active site
1198627007318	phosphorylation site [posttranslational modification]
1198627007319	intermolecular recognition site; other site
1198627007320	dimerization interface [polypeptide binding]; other site
1198627007321	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1198627007322	DNA binding residues [nucleotide binding]
1198627007323	dimerization interface [polypeptide binding]; other site
1198627007324	GMP synthase; Reviewed; Region: guaA; PRK00074
1198627007325	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1198627007326	AMP/PPi binding site [chemical binding]; other site
1198627007327	candidate oxyanion hole; other site
1198627007328	catalytic triad [active]
1198627007329	potential glutamine specificity residues [chemical binding]; other site
1198627007330	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1198627007331	ATP Binding subdomain [chemical binding]; other site
1198627007332	Ligand Binding sites [chemical binding]; other site
1198627007333	Dimerization subdomain; other site
1198627007334	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1198627007335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1198627007336	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1198627007337	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1198627007338	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1198627007339	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1198627007340	phosphate binding site [ion binding]; other site
1198627007341	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1198627007342	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1198627007343	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1198627007344	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1198627007345	active site
1198627007346	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1198627007347	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1198627007348	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627007349	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627007350	DNA binding residues [nucleotide binding]
1198627007351	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1198627007352	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1198627007353	ring oligomerisation interface [polypeptide binding]; other site
1198627007354	ATP/Mg binding site [chemical binding]; other site
1198627007355	stacking interactions; other site
1198627007356	hinge regions; other site
1198627007357	UGMP family protein; Validated; Region: PRK09604
1198627007358	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1198627007359	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1198627007360	Coenzyme A binding pocket [chemical binding]; other site
1198627007361	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1198627007362	Glycoprotease family; Region: Peptidase_M22; pfam00814
1198627007363	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
1198627007364	alanine racemase; Reviewed; Region: alr; PRK00053
1198627007365	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1198627007366	active site
1198627007367	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1198627007368	dimer interface [polypeptide binding]; other site
1198627007369	substrate binding site [chemical binding]; other site
1198627007370	catalytic residues [active]
1198627007371	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1198627007372	L-tyrosine decarboxylase; Provisional; Region: PRK13520
1198627007373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627007374	catalytic residue [active]
1198627007375	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1198627007376	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1198627007377	putative substrate binding site [chemical binding]; other site
1198627007378	putative ATP binding site [chemical binding]; other site
1198627007379	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627007380	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1198627007381	catalytic site [active]
1198627007382	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1198627007383	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1198627007384	glutaminase active site [active]
1198627007385	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1198627007386	dimer interface [polypeptide binding]; other site
1198627007387	active site
1198627007388	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1198627007389	dimer interface [polypeptide binding]; other site
1198627007390	active site
1198627007391	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
1198627007392	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627007393	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
1198627007394	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1198627007395	putative active site [active]
1198627007396	putative metal binding site [ion binding]; other site
1198627007397	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1198627007398	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1198627007399	active site
1198627007400	substrate binding site [chemical binding]; other site
1198627007401	metal binding site [ion binding]; metal-binding site
1198627007402	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1198627007403	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1198627007404	23S rRNA interface [nucleotide binding]; other site
1198627007405	L3 interface [polypeptide binding]; other site
1198627007406	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1198627007407	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1198627007408	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1198627007409	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1198627007410	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1198627007411	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1198627007412	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1198627007413	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1198627007414	active site
1198627007415	catalytic residues [active]
1198627007416	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
1198627007417	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1198627007418	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1198627007419	EamA-like transporter family; Region: EamA; cl17759
1198627007420	Cutinase; Region: Cutinase; pfam01083
1198627007421	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627007422	Cutinase; Region: Cutinase; pfam01083
1198627007423	Cutinase; Region: Cutinase; pfam01083
1198627007424	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1198627007425	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1198627007426	dimerization interface 3.5A [polypeptide binding]; other site
1198627007427	active site
1198627007428	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1198627007429	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1198627007430	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1198627007431	alphaNTD homodimer interface [polypeptide binding]; other site
1198627007432	alphaNTD - beta interaction site [polypeptide binding]; other site
1198627007433	alphaNTD - beta' interaction site [polypeptide binding]; other site
1198627007434	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1198627007435	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1198627007436	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1198627007437	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1198627007438	RNA binding surface [nucleotide binding]; other site
1198627007439	30S ribosomal protein S11; Validated; Region: PRK05309
1198627007440	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1198627007441	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1198627007442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1198627007443	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1198627007444	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1198627007445	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1198627007446	NAD binding site [chemical binding]; other site
1198627007447	substrate binding site [chemical binding]; other site
1198627007448	homodimer interface [polypeptide binding]; other site
1198627007449	active site
1198627007450	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1198627007451	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1198627007452	active site
1198627007453	adenylate kinase; Reviewed; Region: adk; PRK00279
1198627007454	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1198627007455	AMP-binding site [chemical binding]; other site
1198627007456	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1198627007457	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1198627007458	SecY translocase; Region: SecY; pfam00344
1198627007459	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627007460	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627007461	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1198627007462	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1198627007463	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1198627007464	tandem repeat interface [polypeptide binding]; other site
1198627007465	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1198627007466	oligomer interface [polypeptide binding]; other site
1198627007467	active site residues [active]
1198627007468	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1198627007469	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1198627007470	tandem repeat interface [polypeptide binding]; other site
1198627007471	oligomer interface [polypeptide binding]; other site
1198627007472	active site residues [active]
1198627007473	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627007474	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1198627007475	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1198627007476	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1198627007477	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1198627007478	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1198627007479	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1198627007480	5S rRNA interface [nucleotide binding]; other site
1198627007481	L27 interface [polypeptide binding]; other site
1198627007482	23S rRNA interface [nucleotide binding]; other site
1198627007483	L5 interface [polypeptide binding]; other site
1198627007484	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1198627007485	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1198627007486	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1198627007487	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1198627007488	glutamate dehydrogenase; Provisional; Region: PRK09414
1198627007489	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1198627007490	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1198627007491	NAD(P) binding site [chemical binding]; other site
1198627007492	Carboxylesterase family; Region: COesterase; pfam00135
1198627007493	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1198627007494	substrate binding pocket [chemical binding]; other site
1198627007495	catalytic triad [active]
1198627007496	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1198627007497	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1198627007498	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1198627007499	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1198627007500	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1198627007501	RNA binding site [nucleotide binding]; other site
1198627007502	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1198627007503	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1198627007504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627007505	putative substrate translocation pore; other site
1198627007506	Cutinase; Region: Cutinase; pfam01083
1198627007507	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
1198627007508	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1198627007509	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627007510	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1198627007511	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1198627007512	23S rRNA interface [nucleotide binding]; other site
1198627007513	5S rRNA interface [nucleotide binding]; other site
1198627007514	putative antibiotic binding site [chemical binding]; other site
1198627007515	L25 interface [polypeptide binding]; other site
1198627007516	L27 interface [polypeptide binding]; other site
1198627007517	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1198627007518	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1198627007519	G-X-X-G motif; other site
1198627007520	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1198627007521	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1198627007522	putative translocon binding site; other site
1198627007523	protein-rRNA interface [nucleotide binding]; other site
1198627007524	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1198627007525	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1198627007526	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1198627007527	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1198627007528	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1198627007529	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1198627007530	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1198627007531	Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
1198627007532	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1198627007533	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627007534	Cytochrome P450; Region: p450; cl12078
1198627007535	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1198627007536	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1198627007537	ethanolamine permease; Region: 2A0305; TIGR00908
1198627007538	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
1198627007539	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1198627007540	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
1198627007541	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1198627007542	Probable Catalytic site; other site
1198627007543	metal-binding site
1198627007544	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
1198627007545	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
1198627007546	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1198627007547	phosphate binding site [ion binding]; other site
1198627007548	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
1198627007549	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1198627007550	FeS/SAM binding site; other site
1198627007551	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1198627007552	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1198627007553	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627007554	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1198627007555	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627007556	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1198627007557	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627007558	putative DNA binding site [nucleotide binding]; other site
1198627007559	putative Zn2+ binding site [ion binding]; other site
1198627007560	AsnC family; Region: AsnC_trans_reg; pfam01037
1198627007561	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627007562	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627007563	catalytic residue [active]
1198627007564	amino acid transporter; Region: 2A0306; TIGR00909
1198627007565	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1198627007566	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1198627007567	Ligand Binding Site [chemical binding]; other site
1198627007568	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1198627007569	Ligand Binding Site [chemical binding]; other site
1198627007570	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1198627007571	classical (c) SDRs; Region: SDR_c; cd05233
1198627007572	NAD(P) binding site [chemical binding]; other site
1198627007573	active site
1198627007574	elongation factor Tu; Reviewed; Region: PRK00049
1198627007575	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1198627007576	G1 box; other site
1198627007577	GEF interaction site [polypeptide binding]; other site
1198627007578	GTP/Mg2+ binding site [chemical binding]; other site
1198627007579	Switch I region; other site
1198627007580	G2 box; other site
1198627007581	G3 box; other site
1198627007582	Switch II region; other site
1198627007583	G4 box; other site
1198627007584	G5 box; other site
1198627007585	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1198627007586	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1198627007587	Antibiotic Binding Site [chemical binding]; other site
1198627007588	elongation factor G; Reviewed; Region: PRK00007
1198627007589	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1198627007590	G1 box; other site
1198627007591	putative GEF interaction site [polypeptide binding]; other site
1198627007592	GTP/Mg2+ binding site [chemical binding]; other site
1198627007593	Switch I region; other site
1198627007594	G2 box; other site
1198627007595	G3 box; other site
1198627007596	Switch II region; other site
1198627007597	G4 box; other site
1198627007598	G5 box; other site
1198627007599	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1198627007600	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1198627007601	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1198627007602	30S ribosomal protein S7; Validated; Region: PRK05302
1198627007603	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1198627007604	S17 interaction site [polypeptide binding]; other site
1198627007605	S8 interaction site; other site
1198627007606	16S rRNA interaction site [nucleotide binding]; other site
1198627007607	streptomycin interaction site [chemical binding]; other site
1198627007608	23S rRNA interaction site [nucleotide binding]; other site
1198627007609	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1198627007610	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627007611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627007612	WHG domain; Region: WHG; pfam13305
1198627007613	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1198627007614	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627007615	substrate binding site [chemical binding]; other site
1198627007616	oxyanion hole (OAH) forming residues; other site
1198627007617	trimer interface [polypeptide binding]; other site
1198627007618	enoyl-CoA hydratase; Provisional; Region: PRK12478
1198627007619	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627007620	substrate binding site [chemical binding]; other site
1198627007621	oxyanion hole (OAH) forming residues; other site
1198627007622	trimer interface [polypeptide binding]; other site
1198627007623	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1198627007624	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627007625	active site
1198627007626	amino acid transporter; Region: 2A0306; TIGR00909
1198627007627	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1198627007628	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1198627007629	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1198627007630	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1198627007631	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1198627007632	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1198627007633	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1198627007634	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1198627007635	DNA binding site [nucleotide binding]
1198627007636	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1198627007637	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1198627007638	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1198627007639	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1198627007640	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1198627007641	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1198627007642	RPB10 interaction site [polypeptide binding]; other site
1198627007643	RPB1 interaction site [polypeptide binding]; other site
1198627007644	RPB11 interaction site [polypeptide binding]; other site
1198627007645	RPB3 interaction site [polypeptide binding]; other site
1198627007646	RPB12 interaction site [polypeptide binding]; other site
1198627007647	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1198627007648	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1198627007649	molybdopterin cofactor binding site; other site
1198627007650	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1198627007651	molybdopterin cofactor binding site; other site
1198627007652	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1198627007653	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1198627007654	Walker A/P-loop; other site
1198627007655	ATP binding site [chemical binding]; other site
1198627007656	Q-loop/lid; other site
1198627007657	ABC transporter signature motif; other site
1198627007658	Walker B; other site
1198627007659	D-loop; other site
1198627007660	H-loop/switch region; other site
1198627007661	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1198627007662	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1198627007663	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1198627007664	core dimer interface [polypeptide binding]; other site
1198627007665	peripheral dimer interface [polypeptide binding]; other site
1198627007666	L10 interface [polypeptide binding]; other site
1198627007667	L11 interface [polypeptide binding]; other site
1198627007668	putative EF-Tu interaction site [polypeptide binding]; other site
1198627007669	putative EF-G interaction site [polypeptide binding]; other site
1198627007670	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1198627007671	23S rRNA interface [nucleotide binding]; other site
1198627007672	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1198627007673	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627007674	ABC1 family; Region: ABC1; pfam03109
1198627007675	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1198627007676	active site
1198627007677	ATP binding site [chemical binding]; other site
1198627007678	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1198627007679	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1198627007680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627007681	S-adenosylmethionine binding site [chemical binding]; other site
1198627007682	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1198627007683	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627007684	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627007685	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1198627007686	FAD binding domain; Region: FAD_binding_4; pfam01565
1198627007687	diacylglycerol kinase; Reviewed; Region: PRK11914
1198627007688	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1198627007689	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627007690	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627007691	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1198627007692	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1198627007693	DNA binding residues [nucleotide binding]
1198627007694	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1198627007695	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1198627007696	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1198627007697	Histidine kinase; Region: HisKA_3; pfam07730
1198627007698	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1198627007699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627007700	active site
1198627007701	phosphorylation site [posttranslational modification]
1198627007702	intermolecular recognition site; other site
1198627007703	dimerization interface [polypeptide binding]; other site
1198627007704	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1198627007705	DNA binding residues [nucleotide binding]
1198627007706	dimerization interface [polypeptide binding]; other site
1198627007707	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1198627007708	mRNA/rRNA interface [nucleotide binding]; other site
1198627007709	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1198627007710	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1198627007711	23S rRNA interface [nucleotide binding]; other site
1198627007712	L7/L12 interface [polypeptide binding]; other site
1198627007713	putative thiostrepton binding site; other site
1198627007714	L25 interface [polypeptide binding]; other site
1198627007715	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1198627007716	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1198627007717	putative homodimer interface [polypeptide binding]; other site
1198627007718	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1198627007719	heterodimer interface [polypeptide binding]; other site
1198627007720	homodimer interface [polypeptide binding]; other site
1198627007721	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1198627007722	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1198627007723	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1198627007724	active site
1198627007725	catalytic site [active]
1198627007726	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1198627007727	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1198627007728	dimerization interface [polypeptide binding]; other site
1198627007729	DPS ferroxidase diiron center [ion binding]; other site
1198627007730	ion pore; other site
1198627007731	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1198627007732	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1198627007733	proposed catalytic triad [active]
1198627007734	conserved cys residue [active]
1198627007735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1198627007736	Predicted kinase [General function prediction only]; Region: COG0645
1198627007737	AAA domain; Region: AAA_17; pfam13207
1198627007738	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1198627007739	dimer interface [polypeptide binding]; other site
1198627007740	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1198627007741	Ligand Binding Site [chemical binding]; other site
1198627007742	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
1198627007743	putative heme binding pocket [chemical binding]; other site
1198627007744	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1198627007745	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
1198627007746	active site
1198627007747	catalytic triad [active]
1198627007748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1198627007749	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1198627007750	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1198627007751	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1198627007752	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627007753	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
1198627007754	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1198627007755	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1198627007756	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1198627007757	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1198627007758	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1198627007759	FAD binding pocket [chemical binding]; other site
1198627007760	FAD binding motif [chemical binding]; other site
1198627007761	phosphate binding motif [ion binding]; other site
1198627007762	beta-alpha-beta structure motif; other site
1198627007763	NAD(p) ribose binding residues [chemical binding]; other site
1198627007764	NAD binding pocket [chemical binding]; other site
1198627007765	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1198627007766	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627007767	catalytic loop [active]
1198627007768	iron binding site [ion binding]; other site
1198627007769	short chain dehydrogenase; Provisional; Region: PRK07832
1198627007770	classical (c) SDRs; Region: SDR_c; cd05233
1198627007771	NAD(P) binding site [chemical binding]; other site
1198627007772	active site
1198627007773	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627007774	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627007775	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1198627007776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627007777	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627007778	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1198627007779	TIGR03086 family protein; Region: TIGR03086
1198627007780	heat shock protein HtpX; Provisional; Region: PRK03072
1198627007781	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1198627007782	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1198627007783	substrate binding pocket [chemical binding]; other site
1198627007784	chain length determination region; other site
1198627007785	substrate-Mg2+ binding site; other site
1198627007786	catalytic residues [active]
1198627007787	aspartate-rich region 1; other site
1198627007788	active site lid residues [active]
1198627007789	aspartate-rich region 2; other site
1198627007790	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1198627007791	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1198627007792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627007793	S-adenosylmethionine binding site [chemical binding]; other site
1198627007794	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1198627007795	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1198627007796	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1198627007797	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1198627007798	dimer interface [polypeptide binding]; other site
1198627007799	tetramer interface [polypeptide binding]; other site
1198627007800	PYR/PP interface [polypeptide binding]; other site
1198627007801	TPP binding site [chemical binding]; other site
1198627007802	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1198627007803	TPP-binding site; other site
1198627007804	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627007805	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1198627007806	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1198627007807	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1198627007808	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1198627007809	active site
1198627007810	Clp amino terminal domain; Region: Clp_N; pfam02861
1198627007811	Clp amino terminal domain; Region: Clp_N; pfam02861
1198627007812	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1198627007813	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1198627007814	metal binding site [ion binding]; metal-binding site
1198627007815	active site
1198627007816	I-site; other site
1198627007817	Pirin; Region: Pirin; pfam02678
1198627007818	Pirin-related protein [General function prediction only]; Region: COG1741
1198627007819	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1198627007820	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1198627007821	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1198627007822	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1198627007823	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627007824	substrate binding site [chemical binding]; other site
1198627007825	oxyanion hole (OAH) forming residues; other site
1198627007826	trimer interface [polypeptide binding]; other site
1198627007827	short chain dehydrogenase; Provisional; Region: PRK08278
1198627007828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627007829	NAD(P) binding site [chemical binding]; other site
1198627007830	active site
1198627007831	short chain dehydrogenase; Provisional; Region: PRK05866
1198627007832	classical (c) SDRs; Region: SDR_c; cd05233
1198627007833	NAD(P) binding site [chemical binding]; other site
1198627007834	active site
1198627007835	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1198627007836	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627007837	acyl-activating enzyme (AAE) consensus motif; other site
1198627007838	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
1198627007839	AMP binding site [chemical binding]; other site
1198627007840	active site
1198627007841	CoA binding site [chemical binding]; other site
1198627007842	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
1198627007843	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1198627007844	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1198627007845	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1198627007846	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1198627007847	UbiA prenyltransferase family; Region: UbiA; pfam01040
1198627007848	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627007849	Cytochrome P450; Region: p450; cl12078
1198627007850	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627007851	Cytochrome P450; Region: p450; cl12078
1198627007852	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1198627007853	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1198627007854	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1198627007855	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627007856	catalytic residue [active]
1198627007857	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627007858	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627007859	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1198627007860	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1198627007861	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1198627007862	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1198627007863	ResB-like family; Region: ResB; pfam05140
1198627007864	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1198627007865	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1198627007866	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1198627007867	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1198627007868	catalytic residues [active]
1198627007869	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627007870	catalytic core [active]
1198627007871	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1198627007872	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627007873	inhibitor-cofactor binding pocket; inhibition site
1198627007874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627007875	catalytic residue [active]
1198627007876	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1198627007877	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1198627007878	active site
1198627007879	Zn binding site [ion binding]; other site
1198627007880	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1198627007881	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1198627007882	metal-binding site [ion binding]
1198627007883	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1198627007884	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627007885	motif II; other site
1198627007886	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1198627007887	dimer interface [polypeptide binding]; other site
1198627007888	active site
1198627007889	Schiff base residues; other site
1198627007890	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
1198627007891	active site
1198627007892	homodimer interface [polypeptide binding]; other site
1198627007893	SAM binding site [chemical binding]; other site
1198627007894	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1198627007895	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1198627007896	active site
1198627007897	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1198627007898	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1198627007899	domain interfaces; other site
1198627007900	active site
1198627007901	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1198627007902	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1198627007903	tRNA; other site
1198627007904	putative tRNA binding site [nucleotide binding]; other site
1198627007905	putative NADP binding site [chemical binding]; other site
1198627007906	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1198627007907	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1198627007908	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1198627007909	motif II; other site
1198627007910	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1198627007911	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1198627007912	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1198627007913	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1198627007914	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1198627007915	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1198627007916	FMN binding site [chemical binding]; other site
1198627007917	substrate binding site [chemical binding]; other site
1198627007918	putative catalytic residue [active]
1198627007919	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1198627007920	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1198627007921	putative acyl-acceptor binding pocket; other site
1198627007922	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
1198627007923	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1198627007924	putative NAD(P) binding site [chemical binding]; other site
1198627007925	active site
1198627007926	putative substrate binding site [chemical binding]; other site
1198627007927	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1198627007928	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1198627007929	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
1198627007930	active site
1198627007931	diiron metal binding site [ion binding]; other site
1198627007932	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1198627007933	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1198627007934	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1198627007935	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1198627007936	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1198627007937	DNA interaction; other site
1198627007938	Metal-binding active site; metal-binding site
1198627007939	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1198627007940	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1198627007941	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1198627007942	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627007943	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627007944	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1198627007945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627007946	S-adenosylmethionine binding site [chemical binding]; other site
1198627007947	short chain dehydrogenase; Validated; Region: PRK05855
1198627007948	classical (c) SDRs; Region: SDR_c; cd05233
1198627007949	NAD(P) binding site [chemical binding]; other site
1198627007950	active site
1198627007951	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1198627007952	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1198627007953	FMN-binding pocket [chemical binding]; other site
1198627007954	flavin binding motif; other site
1198627007955	phosphate binding motif [ion binding]; other site
1198627007956	beta-alpha-beta structure motif; other site
1198627007957	NAD binding pocket [chemical binding]; other site
1198627007958	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627007959	catalytic loop [active]
1198627007960	iron binding site [ion binding]; other site
1198627007961	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1198627007962	classical (c) SDRs; Region: SDR_c; cd05233
1198627007963	NAD(P) binding site [chemical binding]; other site
1198627007964	active site
1198627007965	classical (c) SDRs; Region: SDR_c; cd05233
1198627007966	NAD(P) binding site [chemical binding]; other site
1198627007967	active site
1198627007968	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627007969	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627007970	Permease; Region: Permease; pfam02405
1198627007971	Permease; Region: Permease; pfam02405
1198627007972	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627007973	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627007974	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627007975	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627007976	short chain dehydrogenase; Provisional; Region: PRK07825
1198627007977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627007978	NAD(P) binding site [chemical binding]; other site
1198627007979	active site
1198627007980	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627007981	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1198627007982	ABC1 family; Region: ABC1; cl17513
1198627007983	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1198627007984	active site
1198627007985	ATP binding site [chemical binding]; other site
1198627007986	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627007987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627007988	active site
1198627007989	phosphorylation site [posttranslational modification]
1198627007990	intermolecular recognition site; other site
1198627007991	dimerization interface [polypeptide binding]; other site
1198627007992	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627007993	DNA binding site [nucleotide binding]
1198627007994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1198627007995	dimer interface [polypeptide binding]; other site
1198627007996	phosphorylation site [posttranslational modification]
1198627007997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627007998	ATP binding site [chemical binding]; other site
1198627007999	Mg2+ binding site [ion binding]; other site
1198627008000	G-X-G motif; other site
1198627008001	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627008002	catalytic core [active]
1198627008003	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1198627008004	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627008005	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627008006	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1198627008007	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1198627008008	short chain dehydrogenase; Provisional; Region: PRK06181
1198627008009	classical (c) SDRs; Region: SDR_c; cd05233
1198627008010	NAD(P) binding site [chemical binding]; other site
1198627008011	active site
1198627008012	4-coumarate--CoA ligase; Region: PLN02246
1198627008013	4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904
1198627008014	acyl-activating enzyme (AAE) consensus motif; other site
1198627008015	active site
1198627008016	putative CoA binding site [chemical binding]; other site
1198627008017	AMP binding site [chemical binding]; other site
1198627008018	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1198627008019	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1198627008020	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1198627008021	putative ADP-binding pocket [chemical binding]; other site
1198627008022	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1198627008023	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1198627008024	short chain dehydrogenase; Provisional; Region: PRK06523
1198627008025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008026	NAD(P) binding site [chemical binding]; other site
1198627008027	active site
1198627008028	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1198627008029	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1198627008030	Predicted transcriptional regulators [Transcription]; Region: COG1733
1198627008031	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1198627008032	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1198627008033	FAD binding domain; Region: FAD_binding_4; pfam01565
1198627008034	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1198627008035	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1198627008036	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1198627008037	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1198627008038	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1198627008039	putative active site [active]
1198627008040	catalytic triad [active]
1198627008041	putative dimer interface [polypeptide binding]; other site
1198627008042	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1198627008043	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1198627008044	intersubunit interface [polypeptide binding]; other site
1198627008045	active site
1198627008046	catalytic residue [active]
1198627008047	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
1198627008048	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1198627008049	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1198627008050	non-specific DNA binding site [nucleotide binding]; other site
1198627008051	salt bridge; other site
1198627008052	sequence-specific DNA binding site [nucleotide binding]; other site
1198627008053	Predicted membrane protein [Function unknown]; Region: COG2733
1198627008054	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627008055	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627008056	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1198627008057	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1198627008058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627008059	S-adenosylmethionine binding site [chemical binding]; other site
1198627008060	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1198627008061	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1198627008062	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1198627008063	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1198627008064	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1198627008065	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
1198627008066	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1198627008067	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1198627008068	isocitrate lyase; Provisional; Region: PRK15063
1198627008069	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1198627008070	tetramer interface [polypeptide binding]; other site
1198627008071	active site
1198627008072	Mg2+/Mn2+ binding site [ion binding]; other site
1198627008073	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1198627008074	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1198627008075	active site 2 [active]
1198627008076	active site 1 [active]
1198627008077	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1198627008078	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1198627008079	Condensation domain; Region: Condensation; pfam00668
1198627008080	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627008081	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627008082	acyl-activating enzyme (AAE) consensus motif; other site
1198627008083	AMP binding site [chemical binding]; other site
1198627008084	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627008085	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1198627008086	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1198627008087	putative NAD(P) binding site [chemical binding]; other site
1198627008088	active site
1198627008089	putative substrate binding site [chemical binding]; other site
1198627008090	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1198627008091	Condensation domain; Region: Condensation; pfam00668
1198627008092	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627008093	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1198627008094	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627008095	acyl-activating enzyme (AAE) consensus motif; other site
1198627008096	AMP binding site [chemical binding]; other site
1198627008097	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627008098	Condensation domain; Region: Condensation; pfam00668
1198627008099	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1198627008100	Condensation domain; Region: Condensation; pfam00668
1198627008101	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627008102	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1198627008103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627008104	S-adenosylmethionine binding site [chemical binding]; other site
1198627008105	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1198627008106	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1198627008107	homodimer interface [polypeptide binding]; other site
1198627008108	active site
1198627008109	TDP-binding site; other site
1198627008110	acceptor substrate-binding pocket; other site
1198627008111	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1198627008112	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1198627008113	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1198627008114	homodimer interface [polypeptide binding]; other site
1198627008115	active site
1198627008116	TDP-binding site; other site
1198627008117	acceptor substrate-binding pocket; other site
1198627008118	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1198627008119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008120	NAD(P) binding site [chemical binding]; other site
1198627008121	active site
1198627008122	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1198627008123	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1198627008124	homodimer interface [polypeptide binding]; other site
1198627008125	active site
1198627008126	TDP-binding site; other site
1198627008127	acceptor substrate-binding pocket; other site
1198627008128	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1198627008129	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1198627008130	substrate binding site; other site
1198627008131	tetramer interface; other site
1198627008132	Transport protein; Region: actII; TIGR00833
1198627008133	Transport protein; Region: actII; TIGR00833
1198627008134	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627008135	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1198627008136	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1198627008137	non-specific DNA binding site [nucleotide binding]; other site
1198627008138	salt bridge; other site
1198627008139	sequence-specific DNA binding site [nucleotide binding]; other site
1198627008140	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1198627008141	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1198627008142	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1198627008143	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1198627008144	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1198627008145	active site
1198627008146	catalytic tetrad [active]
1198627008147	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1198627008148	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1198627008149	DNA binding residues [nucleotide binding]
1198627008150	putative dimer interface [polypeptide binding]; other site
1198627008151	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1198627008152	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1198627008153	Sterol carrier protein domain; Region: SCP2_2; pfam13530
1198627008154	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1198627008155	non-prolyl cis peptide bond; other site
1198627008156	active site
1198627008157	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627008158	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1198627008159	active site clefts [active]
1198627008160	zinc binding site [ion binding]; other site
1198627008161	dimer interface [polypeptide binding]; other site
1198627008162	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
1198627008163	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1198627008164	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627008165	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1198627008166	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1198627008167	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627008168	Secretory lipase; Region: LIP; pfam03583
1198627008169	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1198627008170	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627008171	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
1198627008172	NAD(P) binding site [chemical binding]; other site
1198627008173	catalytic residues [active]
1198627008174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627008175	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627008176	putative substrate translocation pore; other site
1198627008177	PE-PPE domain; Region: PE-PPE; pfam08237
1198627008178	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
1198627008179	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1198627008180	active site
1198627008181	homotetramer interface [polypeptide binding]; other site
1198627008182	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1198627008183	Permease; Region: Permease; pfam02405
1198627008184	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1198627008185	Permease; Region: Permease; pfam02405
1198627008186	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
1198627008187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008188	NAD(P) binding site [chemical binding]; other site
1198627008189	active site
1198627008190	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627008191	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1198627008192	FAD binding site [chemical binding]; other site
1198627008193	substrate binding site [chemical binding]; other site
1198627008194	catalytic base [active]
1198627008195	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627008196	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1198627008197	active site
1198627008198	acyl-CoA synthetase; Validated; Region: PRK07867
1198627008199	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627008200	acyl-activating enzyme (AAE) consensus motif; other site
1198627008201	AMP binding site [chemical binding]; other site
1198627008202	active site
1198627008203	CoA binding site [chemical binding]; other site
1198627008204	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1198627008205	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1198627008206	Nitronate monooxygenase; Region: NMO; pfam03060
1198627008207	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1198627008208	FMN binding site [chemical binding]; other site
1198627008209	substrate binding site [chemical binding]; other site
1198627008210	putative catalytic residue [active]
1198627008211	acyl-CoA synthetase; Validated; Region: PRK07798
1198627008212	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627008213	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
1198627008214	acyl-activating enzyme (AAE) consensus motif; other site
1198627008215	acyl-activating enzyme (AAE) consensus motif; other site
1198627008216	putative AMP binding site [chemical binding]; other site
1198627008217	putative active site [active]
1198627008218	putative CoA binding site [chemical binding]; other site
1198627008219	enoyl-CoA hydratase; Provisional; Region: PRK07799
1198627008220	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627008221	substrate binding site [chemical binding]; other site
1198627008222	oxyanion hole (OAH) forming residues; other site
1198627008223	trimer interface [polypeptide binding]; other site
1198627008224	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
1198627008225	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627008226	ferredoxin-NADP+ reductase; Region: PLN02852
1198627008227	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627008228	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1198627008229	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1198627008230	trimer interface [polypeptide binding]; other site
1198627008231	putative metal binding site [ion binding]; other site
1198627008232	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1198627008233	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
1198627008234	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1198627008235	putative active site [active]
1198627008236	dimerization interface [polypeptide binding]; other site
1198627008237	putative tRNAtyr binding site [nucleotide binding]; other site
1198627008238	short chain dehydrogenase; Provisional; Region: PRK07890
1198627008239	classical (c) SDRs; Region: SDR_c; cd05233
1198627008240	NAD(P) binding site [chemical binding]; other site
1198627008241	active site
1198627008242	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1198627008243	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1198627008244	Active Sites [active]
1198627008245	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1198627008246	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1198627008247	CysD dimerization site [polypeptide binding]; other site
1198627008248	G1 box; other site
1198627008249	putative GEF interaction site [polypeptide binding]; other site
1198627008250	GTP/Mg2+ binding site [chemical binding]; other site
1198627008251	Switch I region; other site
1198627008252	G2 box; other site
1198627008253	G3 box; other site
1198627008254	Switch II region; other site
1198627008255	G4 box; other site
1198627008256	G5 box; other site
1198627008257	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1198627008258	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1198627008259	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1198627008260	ligand-binding site [chemical binding]; other site
1198627008261	carboxylate-amine ligase; Provisional; Region: PRK13517
1198627008262	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1198627008263	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1198627008264	E-class dimer interface [polypeptide binding]; other site
1198627008265	P-class dimer interface [polypeptide binding]; other site
1198627008266	active site
1198627008267	Cu2+ binding site [ion binding]; other site
1198627008268	Zn2+ binding site [ion binding]; other site
1198627008269	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1198627008270	active site
1198627008271	catalytic residues [active]
1198627008272	metal binding site [ion binding]; metal-binding site
1198627008273	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1198627008274	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1198627008275	putative catalytic site [active]
1198627008276	putative phosphate binding site [ion binding]; other site
1198627008277	active site
1198627008278	metal binding site A [ion binding]; metal-binding site
1198627008279	DNA binding site [nucleotide binding]
1198627008280	putative AP binding site [nucleotide binding]; other site
1198627008281	putative metal binding site B [ion binding]; other site
1198627008282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627008283	putative substrate translocation pore; other site
1198627008284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627008285	putative substrate translocation pore; other site
1198627008286	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1198627008287	ThiC-associated domain; Region: ThiC-associated; pfam13667
1198627008288	ThiC family; Region: ThiC; pfam01964
1198627008289	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1198627008290	dimer interface [polypeptide binding]; other site
1198627008291	substrate binding site [chemical binding]; other site
1198627008292	ATP binding site [chemical binding]; other site
1198627008293	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1198627008294	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627008295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627008296	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627008297	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627008298	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1198627008299	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1198627008300	tetrameric interface [polypeptide binding]; other site
1198627008301	NAD binding site [chemical binding]; other site
1198627008302	catalytic residues [active]
1198627008303	substrate binding site [chemical binding]; other site
1198627008304	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1198627008305	Ligand Binding Site [chemical binding]; other site
1198627008306	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1198627008307	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
1198627008308	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627008309	inhibitor-cofactor binding pocket; inhibition site
1198627008310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627008311	catalytic residue [active]
1198627008312	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1198627008313	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627008314	tetramerization interface [polypeptide binding]; other site
1198627008315	NAD(P) binding site [chemical binding]; other site
1198627008316	catalytic residues [active]
1198627008317	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1198627008318	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1198627008319	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1198627008320	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
1198627008321	PA/protease or protease-like domain interface [polypeptide binding]; other site
1198627008322	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
1198627008323	Peptidase family M28; Region: Peptidase_M28; pfam04389
1198627008324	active site
1198627008325	metal binding site [ion binding]; metal-binding site
1198627008326	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1198627008327	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
1198627008328	PA/protease or protease-like domain interface [polypeptide binding]; other site
1198627008329	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
1198627008330	Peptidase family M28; Region: Peptidase_M28; pfam04389
1198627008331	active site
1198627008332	metal binding site [ion binding]; metal-binding site
1198627008333	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1198627008334	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1198627008335	Walker A/P-loop; other site
1198627008336	ATP binding site [chemical binding]; other site
1198627008337	Q-loop/lid; other site
1198627008338	ABC transporter signature motif; other site
1198627008339	Walker B; other site
1198627008340	D-loop; other site
1198627008341	H-loop/switch region; other site
1198627008342	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1198627008343	ThiS interaction site; other site
1198627008344	putative active site [active]
1198627008345	tetramer interface [polypeptide binding]; other site
1198627008346	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1198627008347	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1198627008348	thiamine phosphate binding site [chemical binding]; other site
1198627008349	active site
1198627008350	pyrophosphate binding site [ion binding]; other site
1198627008351	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1198627008352	nudix motif; other site
1198627008353	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1198627008354	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1198627008355	substrate binding pocket [chemical binding]; other site
1198627008356	membrane-bound complex binding site; other site
1198627008357	hinge residues; other site
1198627008358	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1198627008359	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1198627008360	active site
1198627008361	ATP binding site [chemical binding]; other site
1198627008362	substrate binding site [chemical binding]; other site
1198627008363	activation loop (A-loop); other site
1198627008364	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1198627008365	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1198627008366	binding surface
1198627008367	TPR motif; other site
1198627008368	propionate/acetate kinase; Provisional; Region: PRK12379
1198627008369	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1198627008370	phosphate acetyltransferase; Reviewed; Region: PRK05632
1198627008371	DRTGG domain; Region: DRTGG; pfam07085
1198627008372	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1198627008373	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
1198627008374	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1198627008375	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1198627008376	active site
1198627008377	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1198627008378	non-prolyl cis peptide bond; other site
1198627008379	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1198627008380	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1198627008381	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1198627008382	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627008383	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1198627008384	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1198627008385	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1198627008386	substrate binding pocket [chemical binding]; other site
1198627008387	membrane-bound complex binding site; other site
1198627008388	hinge residues; other site
1198627008389	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1198627008390	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1198627008391	Walker A/P-loop; other site
1198627008392	ATP binding site [chemical binding]; other site
1198627008393	Q-loop/lid; other site
1198627008394	ABC transporter signature motif; other site
1198627008395	Walker B; other site
1198627008396	D-loop; other site
1198627008397	H-loop/switch region; other site
1198627008398	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1198627008399	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1198627008400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627008401	dimer interface [polypeptide binding]; other site
1198627008402	conserved gate region; other site
1198627008403	putative PBP binding loops; other site
1198627008404	ABC-ATPase subunit interface; other site
1198627008405	Transport protein; Region: actII; TIGR00833
1198627008406	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
1198627008407	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1198627008408	homodimer interface [polypeptide binding]; other site
1198627008409	substrate-cofactor binding pocket; other site
1198627008410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627008411	catalytic residue [active]
1198627008412	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
1198627008413	active site residue [active]
1198627008414	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
1198627008415	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1198627008416	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1198627008417	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1198627008418	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1198627008419	GDP-binding site [chemical binding]; other site
1198627008420	ACT binding site; other site
1198627008421	IMP binding site; other site
1198627008422	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1198627008423	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1198627008424	active site
1198627008425	intersubunit interface [polypeptide binding]; other site
1198627008426	zinc binding site [ion binding]; other site
1198627008427	Na+ binding site [ion binding]; other site
1198627008428	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1198627008429	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1198627008430	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627008431	active site
1198627008432	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1198627008433	classical (c) SDRs; Region: SDR_c; cd05233
1198627008434	NAD(P) binding site [chemical binding]; other site
1198627008435	active site
1198627008436	Transport protein; Region: actII; TIGR00833
1198627008437	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1198627008438	Clp amino terminal domain; Region: Clp_N; pfam02861
1198627008439	Clp amino terminal domain; Region: Clp_N; pfam02861
1198627008440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627008441	Walker A motif; other site
1198627008442	ATP binding site [chemical binding]; other site
1198627008443	Walker B motif; other site
1198627008444	arginine finger; other site
1198627008445	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1198627008446	Walker A motif; other site
1198627008447	ATP binding site [chemical binding]; other site
1198627008448	Walker B motif; other site
1198627008449	arginine finger; other site
1198627008450	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1198627008451	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1198627008452	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1198627008453	heme-binding site [chemical binding]; other site
1198627008454	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
1198627008455	FAD binding pocket [chemical binding]; other site
1198627008456	FAD binding motif [chemical binding]; other site
1198627008457	phosphate binding motif [ion binding]; other site
1198627008458	beta-alpha-beta structure motif; other site
1198627008459	NAD binding pocket [chemical binding]; other site
1198627008460	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
1198627008461	DNA binding residues [nucleotide binding]
1198627008462	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1198627008463	putative dimer interface [polypeptide binding]; other site
1198627008464	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
1198627008465	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1198627008466	Zn binding sites [ion binding]; other site
1198627008467	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1198627008468	dimer interface [polypeptide binding]; other site
1198627008469	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1198627008470	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1198627008471	dimer interface [polypeptide binding]; other site
1198627008472	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1198627008473	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1198627008474	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1198627008475	nucleotide binding site [chemical binding]; other site
1198627008476	NEF interaction site [polypeptide binding]; other site
1198627008477	SBD interface [polypeptide binding]; other site
1198627008478	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1198627008479	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1198627008480	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1198627008481	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627008482	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1198627008483	G1 box; other site
1198627008484	GTP/Mg2+ binding site [chemical binding]; other site
1198627008485	G2 box; other site
1198627008486	Switch I region; other site
1198627008487	G3 box; other site
1198627008488	Switch II region; other site
1198627008489	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1198627008490	Dynamin family; Region: Dynamin_N; pfam00350
1198627008491	G1 box; other site
1198627008492	GTP/Mg2+ binding site [chemical binding]; other site
1198627008493	G2 box; other site
1198627008494	Switch I region; other site
1198627008495	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1198627008496	G3 box; other site
1198627008497	Switch II region; other site
1198627008498	GTP/Mg2+ binding site [chemical binding]; other site
1198627008499	G4 box; other site
1198627008500	G5 box; other site
1198627008501	Thioredoxin; Region: Thioredoxin_4; pfam13462
1198627008502	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1198627008503	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1198627008504	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1198627008505	4Fe-4S binding domain; Region: Fer4; cl02805
1198627008506	Cysteine-rich domain; Region: CCG; pfam02754
1198627008507	Cysteine-rich domain; Region: CCG; pfam02754
1198627008508	aminotransferase AlaT; Validated; Region: PRK09265
1198627008509	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1198627008510	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627008511	homodimer interface [polypeptide binding]; other site
1198627008512	catalytic residue [active]
1198627008513	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1198627008514	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1198627008515	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1198627008516	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1198627008517	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1198627008518	trimer interface [polypeptide binding]; other site
1198627008519	active site
1198627008520	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627008521	alpha-galactosidase; Region: PLN02229
1198627008522	alpha-galactosidase; Region: PLN02808; cl17638
1198627008523	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1198627008524	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1198627008525	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1198627008526	Sulfatase; Region: Sulfatase; pfam00884
1198627008527	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1198627008528	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1198627008529	Transport protein; Region: actII; TIGR00833
1198627008530	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627008531	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1198627008532	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1198627008533	NAD(P) binding site [chemical binding]; other site
1198627008534	catalytic residues [active]
1198627008535	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627008536	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627008537	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627008538	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
1198627008539	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1198627008540	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175
1198627008541	putative ligand binding site [chemical binding]; other site
1198627008542	putative NAD binding site [chemical binding]; other site
1198627008543	catalytic site [active]
1198627008544	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
1198627008545	classical (c) SDRs; Region: SDR_c; cd05233
1198627008546	NAD(P) binding site [chemical binding]; other site
1198627008547	active site
1198627008548	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627008549	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1198627008550	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627008551	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627008552	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1198627008553	FAD binding site [chemical binding]; other site
1198627008554	substrate binding site [chemical binding]; other site
1198627008555	catalytic base [active]
1198627008556	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
1198627008557	putative hydrophobic ligand binding site [chemical binding]; other site
1198627008558	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1198627008559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008560	acyl-CoA synthetase; Validated; Region: PRK07788
1198627008561	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627008562	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1198627008563	acyl-activating enzyme (AAE) consensus motif; other site
1198627008564	acyl-activating enzyme (AAE) consensus motif; other site
1198627008565	putative AMP binding site [chemical binding]; other site
1198627008566	putative active site [active]
1198627008567	putative CoA binding site [chemical binding]; other site
1198627008568	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1198627008569	nucleotide binding site [chemical binding]; other site
1198627008570	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1198627008571	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
1198627008572	hypothetical protein; Provisional; Region: PRK06062
1198627008573	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627008574	inhibitor-cofactor binding pocket; inhibition site
1198627008575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627008576	catalytic residue [active]
1198627008577	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1198627008578	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1198627008579	tetrameric interface [polypeptide binding]; other site
1198627008580	NAD binding site [chemical binding]; other site
1198627008581	catalytic residues [active]
1198627008582	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1198627008583	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
1198627008584	putative active site [active]
1198627008585	catalytic triad [active]
1198627008586	putative dimer interface [polypeptide binding]; other site
1198627008587	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1198627008588	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1198627008589	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1198627008590	Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978
1198627008591	Secretory lipase; Region: LIP; pfam03583
1198627008592	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
1198627008593	putative FMN binding site [chemical binding]; other site
1198627008594	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1198627008595	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1198627008596	hypothetical protein; Provisional; Region: PRK06126
1198627008597	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1198627008598	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
1198627008599	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1198627008600	putative active site [active]
1198627008601	putative metal binding site [ion binding]; other site
1198627008602	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1198627008603	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1198627008604	AMP-binding domain protein; Validated; Region: PRK07529
1198627008605	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627008606	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627008607	acyl-activating enzyme (AAE) consensus motif; other site
1198627008608	AMP binding site [chemical binding]; other site
1198627008609	active site
1198627008610	acyl-activating enzyme (AAE) consensus motif; other site
1198627008611	CoA binding site [chemical binding]; other site
1198627008612	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1198627008613	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1198627008614	Bacterial transcriptional regulator; Region: IclR; pfam01614
1198627008615	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
1198627008616	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008617	NAD(P) binding site [chemical binding]; other site
1198627008618	active site
1198627008619	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627008620	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1198627008621	catalytic site [active]
1198627008622	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1198627008623	inter-subunit interface; other site
1198627008624	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1198627008625	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627008626	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1198627008627	iron-sulfur cluster [ion binding]; other site
1198627008628	[2Fe-2S] cluster binding site [ion binding]; other site
1198627008629	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
1198627008630	beta subunit interface [polypeptide binding]; other site
1198627008631	alpha subunit interface [polypeptide binding]; other site
1198627008632	active site
1198627008633	substrate binding site [chemical binding]; other site
1198627008634	Fe binding site [ion binding]; other site
1198627008635	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1198627008636	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1198627008637	NAD(P) binding site [chemical binding]; other site
1198627008638	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1198627008639	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1198627008640	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1198627008641	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1198627008642	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1198627008643	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1198627008644	active site
1198627008645	catalytic residues [active]
1198627008646	metal binding site [ion binding]; metal-binding site
1198627008647	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1198627008648	AMP-binding domain protein; Validated; Region: PRK08315
1198627008649	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627008650	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1198627008651	acyl-activating enzyme (AAE) consensus motif; other site
1198627008652	putative AMP binding site [chemical binding]; other site
1198627008653	putative active site [active]
1198627008654	putative CoA binding site [chemical binding]; other site
1198627008655	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1198627008656	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1198627008657	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1198627008658	Bacterial transcriptional regulator; Region: IclR; pfam01614
1198627008659	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1198627008660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627008661	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1198627008662	dimerization interface [polypeptide binding]; other site
1198627008663	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1198627008664	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627008665	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1198627008666	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008667	NAD(P) binding site [chemical binding]; other site
1198627008668	active site
1198627008669	Lysine efflux permease [General function prediction only]; Region: COG1279
1198627008670	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
1198627008671	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1198627008672	catalytic Zn binding site [ion binding]; other site
1198627008673	NAD binding site [chemical binding]; other site
1198627008674	structural Zn binding site [ion binding]; other site
1198627008675	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1198627008676	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1198627008677	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1198627008678	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1198627008679	Coenzyme A binding pocket [chemical binding]; other site
1198627008680	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627008681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627008682	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1198627008683	putative substrate binding pocket [chemical binding]; other site
1198627008684	putative dimerization interface [polypeptide binding]; other site
1198627008685	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1198627008686	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1198627008687	putative dimer interface [polypeptide binding]; other site
1198627008688	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
1198627008689	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1198627008690	homodimer interface [polypeptide binding]; other site
1198627008691	putative substrate binding pocket [chemical binding]; other site
1198627008692	diiron center [ion binding]; other site
1198627008693	Cutinase; Region: Cutinase; pfam01083
1198627008694	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1198627008695	Isochorismatase family; Region: Isochorismatase; pfam00857
1198627008696	catalytic triad [active]
1198627008697	conserved cis-peptide bond; other site
1198627008698	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1198627008699	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1198627008700	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1198627008701	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1198627008702	dimer interface [polypeptide binding]; other site
1198627008703	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1198627008704	catalytic triad [active]
1198627008705	peroxidatic and resolving cysteines [active]
1198627008706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627008707	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1198627008708	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1198627008709	dimerization interface [polypeptide binding]; other site
1198627008710	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1198627008711	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1198627008712	tetramer interface [polypeptide binding]; other site
1198627008713	active site
1198627008714	Mg2+/Mn2+ binding site [ion binding]; other site
1198627008715	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1198627008716	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627008717	DNA-binding site [nucleotide binding]; DNA binding site
1198627008718	FCD domain; Region: FCD; pfam07729
1198627008719	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1198627008720	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1198627008721	NAD binding site [chemical binding]; other site
1198627008722	ligand binding site [chemical binding]; other site
1198627008723	catalytic site [active]
1198627008724	putative amidase; Provisional; Region: PRK06169
1198627008725	Amidase; Region: Amidase; pfam01425
1198627008726	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1198627008727	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
1198627008728	inhibitor-cofactor binding pocket; inhibition site
1198627008729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1198627008730	catalytic residue [active]
1198627008731	succinic semialdehyde dehydrogenase; Region: PLN02278
1198627008732	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1198627008733	tetramerization interface [polypeptide binding]; other site
1198627008734	NAD(P) binding site [chemical binding]; other site
1198627008735	catalytic residues [active]
1198627008736	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1198627008737	tartrate dehydrogenase; Provisional; Region: PRK08194
1198627008738	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
1198627008739	L-aspartate oxidase; Provisional; Region: PRK06175
1198627008740	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1198627008741	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
1198627008742	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1198627008743	catalytic loop [active]
1198627008744	iron binding site [ion binding]; other site
1198627008745	Predicted transcriptional regulators [Transcription]; Region: COG1733
1198627008746	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627008747	dimerization interface [polypeptide binding]; other site
1198627008748	putative DNA binding site [nucleotide binding]; other site
1198627008749	putative Zn2+ binding site [ion binding]; other site
1198627008750	short chain dehydrogenase; Validated; Region: PRK08264
1198627008751	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008752	NAD(P) binding site [chemical binding]; other site
1198627008753	active site
1198627008754	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1198627008755	enoyl-CoA hydratase; Provisional; Region: PRK07509
1198627008756	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627008757	substrate binding site [chemical binding]; other site
1198627008758	oxyanion hole (OAH) forming residues; other site
1198627008759	trimer interface [polypeptide binding]; other site
1198627008760	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1198627008761	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1198627008762	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1198627008763	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1198627008764	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1198627008765	active site
1198627008766	ATP binding site [chemical binding]; other site
1198627008767	substrate binding site [chemical binding]; other site
1198627008768	activation loop (A-loop); other site
1198627008769	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1198627008770	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1198627008771	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1198627008772	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1198627008773	FAD binding site [chemical binding]; other site
1198627008774	substrate binding site [chemical binding]; other site
1198627008775	catalytic residues [active]
1198627008776	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1198627008777	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1198627008778	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1198627008779	Moco binding site; other site
1198627008780	metal coordination site [ion binding]; other site
1198627008781	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1198627008782	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1198627008783	dimer interface [polypeptide binding]; other site
1198627008784	active site
1198627008785	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1198627008786	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008787	NAD(P) binding site [chemical binding]; other site
1198627008788	active site
1198627008789	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1198627008790	TIGR03086 family protein; Region: TIGR03086
1198627008791	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1198627008792	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1198627008793	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1198627008794	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1198627008795	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1198627008796	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1198627008797	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1198627008798	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
1198627008799	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1198627008800	acyl-activating enzyme (AAE) consensus motif; other site
1198627008801	active site
1198627008802	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627008803	Cytochrome P450; Region: p450; cl12078
1198627008804	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627008805	Cytochrome P450; Region: p450; cl12078
1198627008806	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1198627008807	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1198627008808	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1198627008809	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1198627008810	Sulfatase; Region: Sulfatase; pfam00884
1198627008811	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1198627008812	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1198627008813	short chain dehydrogenase; Provisional; Region: PRK07832
1198627008814	classical (c) SDRs; Region: SDR_c; cd05233
1198627008815	NAD(P) binding site [chemical binding]; other site
1198627008816	active site
1198627008817	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1198627008818	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1198627008819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627008820	S-adenosylmethionine binding site [chemical binding]; other site
1198627008821	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
1198627008822	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1198627008823	NAD binding site [chemical binding]; other site
1198627008824	catalytic residues [active]
1198627008825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627008826	metabolite-proton symporter; Region: 2A0106; TIGR00883
1198627008827	putative substrate translocation pore; other site
1198627008828	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1198627008829	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1198627008830	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130
1198627008831	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1198627008832	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1198627008833	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
1198627008834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627008835	NAD(P) binding site [chemical binding]; other site
1198627008836	active site
1198627008837	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1198627008838	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1198627008839	putative Zn2+ binding site [ion binding]; other site
1198627008840	Bacterial transcriptional regulator; Region: IclR; pfam01614
1198627008841	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1198627008842	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1198627008843	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627008844	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1198627008845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627008846	active site
1198627008847	phosphorylation site [posttranslational modification]
1198627008848	intermolecular recognition site; other site
1198627008849	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1198627008850	DNA binding residues [nucleotide binding]
1198627008851	dimerization interface [polypeptide binding]; other site
1198627008852	GAF domain; Region: GAF_3; pfam13492
1198627008853	Histidine kinase; Region: HisKA_3; pfam07730
1198627008854	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1198627008855	ATP binding site [chemical binding]; other site
1198627008856	G-X-G motif; other site
1198627008857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627008858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627008859	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1198627008860	active site
1198627008861	substrate-binding site [chemical binding]; other site
1198627008862	metal-binding site [ion binding]
1198627008863	GTP binding site [chemical binding]; other site
1198627008864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627008865	S-adenosylmethionine binding site [chemical binding]; other site
1198627008866	MMPL family; Region: MMPL; pfam03176
1198627008867	MMPL family; Region: MMPL; pfam03176
1198627008868	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1198627008869	Permease; Region: Permease; pfam02405
1198627008870	Permease; Region: Permease; pfam02405
1198627008871	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1198627008872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627008873	active site
1198627008874	phosphorylation site [posttranslational modification]
1198627008875	intermolecular recognition site; other site
1198627008876	dimerization interface [polypeptide binding]; other site
1198627008877	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1198627008878	DNA binding residues [nucleotide binding]
1198627008879	dimerization interface [polypeptide binding]; other site
1198627008880	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1198627008881	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1198627008882	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627008883	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1198627008884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1198627008885	dimerization interface [polypeptide binding]; other site
1198627008886	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1198627008887	cyclase homology domain; Region: CHD; cd07302
1198627008888	nucleotidyl binding site; other site
1198627008889	metal binding site [ion binding]; metal-binding site
1198627008890	dimer interface [polypeptide binding]; other site
1198627008891	YceI-like domain; Region: YceI; pfam04264
1198627008892	MMPL family; Region: MMPL; pfam03176
1198627008893	MMPL family; Region: MMPL; pfam03176
1198627008894	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1198627008895	Sterol carrier protein domain; Region: SCP2_2; pfam13530
1198627008896	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1198627008897	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1198627008898	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1198627008899	active site
1198627008900	Zn binding site [ion binding]; other site
1198627008901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1198627008902	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1198627008903	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1198627008904	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627008905	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627008906	active site
1198627008907	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1198627008908	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1198627008909	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1198627008910	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1198627008911	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1198627008912	carboxyltransferase (CT) interaction site; other site
1198627008913	biotinylation site [posttranslational modification]; other site
1198627008914	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1198627008915	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1198627008916	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1198627008917	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1198627008918	putative homodimer interface [polypeptide binding]; other site
1198627008919	putative homotetramer interface [polypeptide binding]; other site
1198627008920	putative allosteric switch controlling residues; other site
1198627008921	putative metal binding site [ion binding]; other site
1198627008922	putative homodimer-homodimer interface [polypeptide binding]; other site
1198627008923	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1198627008924	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1198627008925	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627008926	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627008927	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1198627008928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627008929	S-adenosylmethionine binding site [chemical binding]; other site
1198627008930	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1198627008931	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1198627008932	RNA polymerase factor sigma-70; Validated; Region: PRK08241
1198627008933	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627008934	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627008935	DNA binding residues [nucleotide binding]
1198627008936	SnoaL-like domain; Region: SnoaL_2; pfam12680
1198627008937	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1198627008938	Zn binding site [ion binding]; other site
1198627008939	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1198627008940	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627008941	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1198627008942	acyl-activating enzyme (AAE) consensus motif; other site
1198627008943	acyl-activating enzyme (AAE) consensus motif; other site
1198627008944	putative AMP binding site [chemical binding]; other site
1198627008945	putative active site [active]
1198627008946	putative CoA binding site [chemical binding]; other site
1198627008947	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
1198627008948	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1198627008949	NAD binding site [chemical binding]; other site
1198627008950	catalytic Zn binding site [ion binding]; other site
1198627008951	substrate binding site [chemical binding]; other site
1198627008952	structural Zn binding site [ion binding]; other site
1198627008953	Pirin-related protein [General function prediction only]; Region: COG1741
1198627008954	Pirin; Region: Pirin; pfam02678
1198627008955	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
1198627008956	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627008957	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1198627008958	acyl-activating enzyme (AAE) consensus motif; other site
1198627008959	acyl-activating enzyme (AAE) consensus motif; other site
1198627008960	putative AMP binding site [chemical binding]; other site
1198627008961	putative active site [active]
1198627008962	putative CoA binding site [chemical binding]; other site
1198627008963	enoyl-CoA hydratase; Provisional; Region: PRK06688
1198627008964	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627008965	substrate binding site [chemical binding]; other site
1198627008966	oxyanion hole (OAH) forming residues; other site
1198627008967	trimer interface [polypeptide binding]; other site
1198627008968	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1198627008969	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627008970	DNA-binding site [nucleotide binding]; DNA binding site
1198627008971	FCD domain; Region: FCD; pfam07729
1198627008972	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1198627008973	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1198627008974	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1198627008975	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1198627008976	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1198627008977	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1198627008978	ligand binding site [chemical binding]; other site
1198627008979	homodimer interface [polypeptide binding]; other site
1198627008980	NAD(P) binding site [chemical binding]; other site
1198627008981	trimer interface B [polypeptide binding]; other site
1198627008982	trimer interface A [polypeptide binding]; other site
1198627008983	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1198627008984	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1198627008985	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1198627008986	putative dimer interface [polypeptide binding]; other site
1198627008987	N-terminal domain interface [polypeptide binding]; other site
1198627008988	putative substrate binding pocket (H-site) [chemical binding]; other site
1198627008989	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627008990	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627008991	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627008992	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627008993	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627008994	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627008995	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627008996	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627008997	enoyl-CoA hydratase; Provisional; Region: PRK08252
1198627008998	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1198627008999	substrate binding site [chemical binding]; other site
1198627009000	oxyanion hole (OAH) forming residues; other site
1198627009001	trimer interface [polypeptide binding]; other site
1198627009002	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1198627009003	Permease; Region: Permease; pfam02405
1198627009004	Permease; Region: Permease; pfam02405
1198627009005	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1198627009006	putative active site [active]
1198627009007	putative catalytic site [active]
1198627009008	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1198627009009	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1198627009010	NAD(P) binding site [chemical binding]; other site
1198627009011	short chain dehydrogenase; Provisional; Region: PRK07791
1198627009012	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1198627009013	NAD binding site [chemical binding]; other site
1198627009014	homodimer interface [polypeptide binding]; other site
1198627009015	active site
1198627009016	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1198627009017	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
1198627009018	NAD(P) binding site [chemical binding]; other site
1198627009019	catalytic residues [active]
1198627009020	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627009021	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627009022	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627009023	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1198627009024	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1198627009025	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1198627009026	dimer interface [polypeptide binding]; other site
1198627009027	active site
1198627009028	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627009029	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627009030	active site
1198627009031	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1198627009032	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1198627009033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627009034	S-adenosylmethionine binding site [chemical binding]; other site
1198627009035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1198627009036	putative substrate translocation pore; other site
1198627009037	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1198627009038	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1198627009039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1198627009040	sequence-specific DNA binding site [nucleotide binding]; other site
1198627009041	salt bridge; other site
1198627009042	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1198627009043	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1198627009044	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1198627009045	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1198627009046	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1198627009047	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1198627009048	tetramer interface [polypeptide binding]; other site
1198627009049	active site
1198627009050	Mg2+/Mn2+ binding site [ion binding]; other site
1198627009051	citrate synthase; Provisional; Region: PRK14033
1198627009052	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
1198627009053	dimer interface [polypeptide binding]; other site
1198627009054	active site
1198627009055	citrylCoA binding site [chemical binding]; other site
1198627009056	oxalacetate/citrate binding site [chemical binding]; other site
1198627009057	coenzyme A binding site [chemical binding]; other site
1198627009058	catalytic triad [active]
1198627009059	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1198627009060	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1198627009061	THF binding site; other site
1198627009062	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1198627009063	substrate binding site [chemical binding]; other site
1198627009064	THF binding site; other site
1198627009065	zinc-binding site [ion binding]; other site
1198627009066	acyl-CoA synthetase; Validated; Region: PRK06188
1198627009067	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1198627009068	putative active site [active]
1198627009069	putative CoA binding site [chemical binding]; other site
1198627009070	putative AMP binding site [chemical binding]; other site
1198627009071	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1198627009072	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1198627009073	short chain dehydrogenase; Provisional; Region: PRK07814
1198627009074	classical (c) SDRs; Region: SDR_c; cd05233
1198627009075	NAD(P) binding site [chemical binding]; other site
1198627009076	active site
1198627009077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627009078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627009079	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1198627009080	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
1198627009081	putative active site [active]
1198627009082	putative FMN binding site [chemical binding]; other site
1198627009083	putative substrate binding site [chemical binding]; other site
1198627009084	putative catalytic residue [active]
1198627009085	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1198627009086	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1198627009087	dimer interface [polypeptide binding]; other site
1198627009088	active site
1198627009089	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
1198627009090	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1198627009091	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1198627009092	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1198627009093	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
1198627009094	putative transporter; Provisional; Region: PRK10484
1198627009095	Na binding site [ion binding]; other site
1198627009096	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1198627009097	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1198627009098	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
1198627009099	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1198627009100	catalytic residue [active]
1198627009101	putative amidase; Provisional; Region: PRK06169
1198627009102	Amidase; Region: Amidase; pfam01425
1198627009103	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1198627009104	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1198627009105	DNA-binding site [nucleotide binding]; DNA binding site
1198627009106	FCD domain; Region: FCD; pfam07729
1198627009107	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1198627009108	active site
1198627009109	catalytic residues [active]
1198627009110	metal binding site [ion binding]; metal-binding site
1198627009111	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1198627009112	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1198627009113	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1198627009114	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1198627009115	short chain dehydrogenase; Provisional; Region: PRK12744
1198627009116	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1198627009117	NADP binding site [chemical binding]; other site
1198627009118	homodimer interface [polypeptide binding]; other site
1198627009119	active site
1198627009120	substrate binding site [chemical binding]; other site
1198627009121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627009122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627009123	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1198627009124	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627009125	active site
1198627009126	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1198627009127	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1198627009128	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1198627009129	classical (c) SDRs; Region: SDR_c; cd05233
1198627009130	NAD(P) binding site [chemical binding]; other site
1198627009131	active site
1198627009132	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627009133	acyl-activating enzyme (AAE) consensus motif; other site
1198627009134	AMP binding site [chemical binding]; other site
1198627009135	active site
1198627009136	CoA binding site [chemical binding]; other site
1198627009137	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1198627009138	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1198627009139	Walker A/P-loop; other site
1198627009140	ATP binding site [chemical binding]; other site
1198627009141	Q-loop/lid; other site
1198627009142	ABC transporter signature motif; other site
1198627009143	Walker B; other site
1198627009144	D-loop; other site
1198627009145	H-loop/switch region; other site
1198627009146	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1198627009147	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1198627009148	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1198627009149	catalytic residue [active]
1198627009150	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
1198627009151	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1198627009152	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1198627009153	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1198627009154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627009155	NAD(P) binding site [chemical binding]; other site
1198627009156	active site
1198627009157	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1198627009158	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1198627009159	active site
1198627009160	TDP-binding site; other site
1198627009161	acceptor substrate-binding pocket; other site
1198627009162	homodimer interface [polypeptide binding]; other site
1198627009163	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627009164	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1198627009165	acyl-activating enzyme (AAE) consensus motif; other site
1198627009166	AMP binding site [chemical binding]; other site
1198627009167	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627009168	Condensation domain; Region: Condensation; pfam00668
1198627009169	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1198627009170	Condensation domain; Region: Condensation; pfam00668
1198627009171	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627009172	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1198627009173	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627009174	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627009175	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
1198627009176	acyl-activating enzyme (AAE) consensus motif; other site
1198627009177	AMP binding site [chemical binding]; other site
1198627009178	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627009179	Condensation domain; Region: Condensation; pfam00668
1198627009180	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627009181	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1198627009182	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627009183	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1198627009184	acyl-activating enzyme (AAE) consensus motif; other site
1198627009185	AMP binding site [chemical binding]; other site
1198627009186	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627009187	Condensation domain; Region: Condensation; pfam00668
1198627009188	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1198627009189	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1198627009190	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1198627009191	acyl-activating enzyme (AAE) consensus motif; other site
1198627009192	AMP binding site [chemical binding]; other site
1198627009193	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627009194	Condensation domain; Region: Condensation; pfam00668
1198627009195	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1198627009196	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627009197	Cytochrome P450; Region: p450; cl12078
1198627009198	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1198627009199	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1198627009200	homodimer interface [polypeptide binding]; other site
1198627009201	active site
1198627009202	TDP-binding site; other site
1198627009203	acceptor substrate-binding pocket; other site
1198627009204	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1198627009205	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1198627009206	homodimer interface [polypeptide binding]; other site
1198627009207	active site
1198627009208	TDP-binding site; other site
1198627009209	acceptor substrate-binding pocket; other site
1198627009210	Transport protein; Region: actII; TIGR00833
1198627009211	Transport protein; Region: actII; TIGR00833
1198627009212	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1198627009213	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627009214	Secretory lipase; Region: LIP; pfam03583
1198627009215	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1198627009216	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627009217	acyl-activating enzyme (AAE) consensus motif; other site
1198627009218	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1198627009219	AMP binding site [chemical binding]; other site
1198627009220	active site
1198627009221	acyl-activating enzyme (AAE) consensus motif; other site
1198627009222	CoA binding site [chemical binding]; other site
1198627009223	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1198627009224	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1198627009225	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627009226	NAD(P) binding site [chemical binding]; other site
1198627009227	active site
1198627009228	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1198627009229	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1198627009230	potassium/proton antiporter; Reviewed; Region: PRK05326
1198627009231	TrkA-C domain; Region: TrkA_C; pfam02080
1198627009232	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1198627009233	TrkA-N domain; Region: TrkA_N; pfam02254
1198627009234	TrkA-C domain; Region: TrkA_C; pfam02080
1198627009235	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
1198627009236	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1198627009237	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1198627009238	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1198627009239	putative DNA binding site [nucleotide binding]; other site
1198627009240	catalytic residue [active]
1198627009241	putative H2TH interface [polypeptide binding]; other site
1198627009242	putative catalytic residues [active]
1198627009243	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1198627009244	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1198627009245	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1198627009246	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1198627009247	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627009248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627009249	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1198627009250	dimerization interface [polypeptide binding]; other site
1198627009251	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1198627009252	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1198627009253	Thioredoxin; Region: Thioredoxin_4; cl17273
1198627009254	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1198627009255	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1198627009256	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1198627009257	metal binding site [ion binding]; metal-binding site
1198627009258	putative dimer interface [polypeptide binding]; other site
1198627009259	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1198627009260	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627009261	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1198627009262	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627009263	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627009264	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
1198627009265	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1198627009266	NAD(P) binding site [chemical binding]; other site
1198627009267	active site
1198627009268	hypothetical protein; Provisional; Region: PRK10279
1198627009269	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1198627009270	nucleophile elbow; other site
1198627009271	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1198627009272	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1198627009273	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1198627009274	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1198627009275	active site
1198627009276	nucleophile elbow; other site
1198627009277	Predicted membrane protein [Function unknown]; Region: COG1511
1198627009278	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1198627009279	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1198627009280	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1198627009281	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1198627009282	Cupin; Region: Cupin_1; smart00835
1198627009283	Transport protein; Region: actII; TIGR00833
1198627009284	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1198627009285	cyclase homology domain; Region: CHD; cd07302
1198627009286	nucleotidyl binding site; other site
1198627009287	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1198627009288	metal binding site [ion binding]; metal-binding site
1198627009289	dimer interface [polypeptide binding]; other site
1198627009290	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1198627009291	heme binding pocket [chemical binding]; other site
1198627009292	heme ligand [chemical binding]; other site
1198627009293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1198627009294	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1198627009295	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1198627009296	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
1198627009297	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1198627009298	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627009299	Walker A/P-loop; other site
1198627009300	ATP binding site [chemical binding]; other site
1198627009301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1198627009302	ATP binding site [chemical binding]; other site
1198627009303	Q-loop/lid; other site
1198627009304	Q-loop/lid; other site
1198627009305	ABC transporter signature motif; other site
1198627009306	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627009307	Walker B; other site
1198627009308	D-loop; other site
1198627009309	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1198627009310	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1198627009311	PPE family; Region: PPE; pfam00823
1198627009312	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627009313	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627009314	short chain dehydrogenase; Provisional; Region: PRK05866
1198627009315	classical (c) SDRs; Region: SDR_c; cd05233
1198627009316	NAD(P) binding site [chemical binding]; other site
1198627009317	active site
1198627009318	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1198627009319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1198627009320	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1198627009321	dimerization interface [polypeptide binding]; other site
1198627009322	substrate binding pocket [chemical binding]; other site
1198627009323	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1198627009324	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627009325	Beta-lactamase; Region: Beta-lactamase; pfam00144
1198627009326	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1198627009327	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1198627009328	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1198627009329	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1198627009330	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1198627009331	Predicted esterase [General function prediction only]; Region: COG0627
1198627009332	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1198627009333	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1198627009334	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1198627009335	catalytic residues [active]
1198627009336	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1198627009337	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1198627009338	active site
1198627009339	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1198627009340	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1198627009341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1198627009342	active site
1198627009343	phosphorylation site [posttranslational modification]
1198627009344	intermolecular recognition site; other site
1198627009345	dimerization interface [polypeptide binding]; other site
1198627009346	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1198627009347	DNA binding site [nucleotide binding]
1198627009348	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1198627009349	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1198627009350	Walker A/P-loop; other site
1198627009351	ATP binding site [chemical binding]; other site
1198627009352	Q-loop/lid; other site
1198627009353	ABC transporter signature motif; other site
1198627009354	Walker B; other site
1198627009355	D-loop; other site
1198627009356	H-loop/switch region; other site
1198627009357	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1198627009358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627009359	dimer interface [polypeptide binding]; other site
1198627009360	conserved gate region; other site
1198627009361	putative PBP binding loops; other site
1198627009362	ABC-ATPase subunit interface; other site
1198627009363	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1198627009364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1198627009365	dimer interface [polypeptide binding]; other site
1198627009366	conserved gate region; other site
1198627009367	putative PBP binding loops; other site
1198627009368	ABC-ATPase subunit interface; other site
1198627009369	PBP superfamily domain; Region: PBP_like_2; cl17296
1198627009370	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1198627009371	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1198627009372	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1198627009373	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
1198627009374	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1198627009375	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1198627009376	arsenical-resistance protein; Region: acr3; TIGR00832
1198627009377	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1198627009378	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627009379	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1198627009380	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1198627009381	trimer interface [polypeptide binding]; other site
1198627009382	active site
1198627009383	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1198627009384	active site
1198627009385	DNA binding site [nucleotide binding]
1198627009386	Int/Topo IB signature motif; other site
1198627009387	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1198627009388	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1198627009389	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
1198627009390	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352
1198627009391	active site
1198627009392	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1198627009393	active site
1198627009394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1198627009395	Coenzyme A binding pocket [chemical binding]; other site
1198627009396	replicative DNA helicase; Region: DnaB; TIGR00665
1198627009397	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1198627009398	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1198627009399	Walker A motif; other site
1198627009400	ATP binding site [chemical binding]; other site
1198627009401	Walker B motif; other site
1198627009402	DNA binding loops [nucleotide binding]
1198627009403	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1198627009404	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1198627009405	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1198627009406	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1198627009407	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1198627009408	dimer interface [polypeptide binding]; other site
1198627009409	ssDNA binding site [nucleotide binding]; other site
1198627009410	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1198627009411	Transglycosylase; Region: Transgly; pfam00912
1198627009412	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1198627009413	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1198627009414	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1198627009415	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1198627009416	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1198627009417	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
1198627009418	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1198627009419	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1198627009420	Methyl-coenzyme M reductase operon protein C; Region: MCR_C; cl01674
1198627009421	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1198627009422	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1198627009423	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1198627009424	active site
1198627009425	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1198627009426	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1198627009427	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1198627009428	classical (c) SDRs; Region: SDR_c; cd05233
1198627009429	NAD(P) binding site [chemical binding]; other site
1198627009430	active site
1198627009431	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1198627009432	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1198627009433	E3 interaction surface; other site
1198627009434	lipoyl attachment site [posttranslational modification]; other site
1198627009435	e3 binding domain; Region: E3_binding; pfam02817
1198627009436	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1198627009437	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1198627009438	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1198627009439	alpha subunit interface [polypeptide binding]; other site
1198627009440	TPP binding site [chemical binding]; other site
1198627009441	heterodimer interface [polypeptide binding]; other site
1198627009442	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1198627009443	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1198627009444	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1198627009445	tetramer interface [polypeptide binding]; other site
1198627009446	TPP-binding site [chemical binding]; other site
1198627009447	heterodimer interface [polypeptide binding]; other site
1198627009448	phosphorylation loop region [posttranslational modification]
1198627009449	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1198627009450	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1198627009451	AsnC family; Region: AsnC_trans_reg; pfam01037
1198627009452	Predicted membrane protein [Function unknown]; Region: COG2311
1198627009453	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1198627009454	short chain dehydrogenase; Provisional; Region: PRK08219
1198627009455	classical (c) SDRs; Region: SDR_c; cd05233
1198627009456	NAD(P) binding site [chemical binding]; other site
1198627009457	active site
1198627009458	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1198627009459	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1198627009460	HIGH motif; other site
1198627009461	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1198627009462	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1198627009463	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1198627009464	active site
1198627009465	KMSKS motif; other site
1198627009466	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1198627009467	tRNA binding surface [nucleotide binding]; other site
1198627009468	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1198627009469	hypothetical protein; Validated; Region: PRK00228
1198627009470	H+ Antiporter protein; Region: 2A0121; TIGR00900
1198627009471	TIGR03084 family protein; Region: TIGR03084
1198627009472	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1198627009473	Wyosine base formation; Region: Wyosine_form; pfam08608
1198627009474	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1198627009475	hypothetical protein; Provisional; Region: PRK10621
1198627009476	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1198627009477	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1198627009478	active site
1198627009479	NTP binding site [chemical binding]; other site
1198627009480	metal binding triad [ion binding]; metal-binding site
1198627009481	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1198627009482	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1198627009483	Zn2+ binding site [ion binding]; other site
1198627009484	Mg2+ binding site [ion binding]; other site
1198627009485	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1198627009486	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1198627009487	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1198627009488	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1198627009489	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1198627009490	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1198627009491	DNA binding residues [nucleotide binding]
1198627009492	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1198627009493	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1198627009494	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1198627009495	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1198627009496	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1198627009497	catalytic residues [active]
1198627009498	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1198627009499	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1198627009500	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1198627009501	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1198627009502	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1198627009503	active site
1198627009504	metal binding site [ion binding]; metal-binding site
1198627009505	Cytochrome P450; Region: p450; cl12078
1198627009506	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1198627009507	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1198627009508	ParB-like nuclease domain; Region: ParBc; pfam02195
1198627009509	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1198627009510	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1198627009511	P-loop; other site
1198627009512	Magnesium ion binding site [ion binding]; other site
1198627009513	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1198627009514	Magnesium ion binding site [ion binding]; other site
1198627009515	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1198627009516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1198627009517	S-adenosylmethionine binding site [chemical binding]; other site
1198627009518	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1198627009519	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1198627009520	G-X-X-G motif; other site
1198627009521	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1198627009522	RxxxH motif; other site
1198627009523	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449