-- dump date 20140619_153632 -- class Genbank::misc_feature -- table misc_feature_note -- id note 246196000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 246196000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196000003 Walker A motif; other site 246196000004 ATP binding site [chemical binding]; other site 246196000005 Walker B motif; other site 246196000006 arginine finger; other site 246196000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 246196000008 DnaA box-binding interface [nucleotide binding]; other site 246196000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 246196000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 246196000011 putative DNA binding surface [nucleotide binding]; other site 246196000012 dimer interface [polypeptide binding]; other site 246196000013 beta-clamp/clamp loader binding surface; other site 246196000014 beta-clamp/translesion DNA polymerase binding surface; other site 246196000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 246196000017 recF protein; Region: recf; TIGR00611 246196000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 246196000019 Walker A/P-loop; other site 246196000020 ATP binding site [chemical binding]; other site 246196000021 Q-loop/lid; other site 246196000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000023 ABC transporter signature motif; other site 246196000024 Walker B; other site 246196000025 D-loop; other site 246196000026 H-loop/switch region; other site 246196000027 hypothetical protein; Provisional; Region: PRK03195 246196000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 246196000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196000030 Mg2+ binding site [ion binding]; other site 246196000031 G-X-G motif; other site 246196000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 246196000033 anchoring element; other site 246196000034 dimer interface [polypeptide binding]; other site 246196000035 ATP binding site [chemical binding]; other site 246196000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 246196000037 active site 246196000038 putative metal-binding site [ion binding]; other site 246196000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246196000040 DNA gyrase subunit A; Validated; Region: PRK05560 246196000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 246196000042 CAP-like domain; other site 246196000043 active site 246196000044 primary dimer interface [polypeptide binding]; other site 246196000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 246196000052 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246196000053 FAD binding pocket [chemical binding]; other site 246196000054 FAD binding motif [chemical binding]; other site 246196000055 phosphate binding motif [ion binding]; other site 246196000056 NAD binding pocket [chemical binding]; other site 246196000057 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 246196000058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246196000059 ABC-ATPase subunit interface; other site 246196000060 dimer interface [polypeptide binding]; other site 246196000061 putative PBP binding regions; other site 246196000062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 246196000063 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246196000064 ABC-ATPase subunit interface; other site 246196000065 dimer interface [polypeptide binding]; other site 246196000066 putative PBP binding regions; other site 246196000067 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196000068 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246196000069 Walker A/P-loop; other site 246196000070 ATP binding site [chemical binding]; other site 246196000071 Q-loop/lid; other site 246196000072 ABC transporter signature motif; other site 246196000073 Walker B; other site 246196000074 D-loop; other site 246196000075 H-loop/switch region; other site 246196000076 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 246196000077 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 246196000078 active site 246196000079 substrate binding site [chemical binding]; other site 246196000080 cosubstrate binding site; other site 246196000081 catalytic site [active] 246196000082 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 246196000083 MbtH-like protein; Region: MbtH; pfam03621 246196000084 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196000085 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196000086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000087 Walker A/P-loop; other site 246196000088 ATP binding site [chemical binding]; other site 246196000089 Q-loop/lid; other site 246196000090 ABC transporter signature motif; other site 246196000091 Walker B; other site 246196000092 D-loop; other site 246196000093 H-loop/switch region; other site 246196000094 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196000095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000096 Walker A/P-loop; other site 246196000097 ATP binding site [chemical binding]; other site 246196000098 ABC transporter; Region: ABC_tran; pfam00005 246196000099 Q-loop/lid; other site 246196000100 ABC transporter signature motif; other site 246196000101 Walker B; other site 246196000102 D-loop; other site 246196000103 H-loop/switch region; other site 246196000104 peptide synthase; Provisional; Region: PRK12316 246196000105 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000106 acyl-activating enzyme (AAE) consensus motif; other site 246196000107 AMP binding site [chemical binding]; other site 246196000108 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000109 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196000110 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000111 acyl-activating enzyme (AAE) consensus motif; other site 246196000112 AMP binding site [chemical binding]; other site 246196000113 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000114 acyl-activating enzyme (AAE) consensus motif; other site 246196000115 AMP binding site [chemical binding]; other site 246196000116 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000117 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196000118 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000119 acyl-activating enzyme (AAE) consensus motif; other site 246196000120 AMP binding site [chemical binding]; other site 246196000121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000122 Condensation domain; Region: Condensation; pfam00668 246196000123 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196000124 Condensation domain; Region: Condensation; pfam00668 246196000125 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196000126 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000127 acyl-activating enzyme (AAE) consensus motif; other site 246196000128 AMP binding site [chemical binding]; other site 246196000129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000130 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 246196000131 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196000132 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000133 acyl-activating enzyme (AAE) consensus motif; other site 246196000134 AMP binding site [chemical binding]; other site 246196000135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000136 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 246196000137 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 246196000138 siderophore binding site; other site 246196000139 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 246196000140 tetramerization interface [polypeptide binding]; other site 246196000141 active site 246196000142 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 246196000143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196000144 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 246196000145 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246196000146 active site 246196000147 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 246196000148 putative septation inhibitor protein; Reviewed; Region: PRK00159 246196000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 246196000150 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 246196000151 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 246196000152 Glutamine amidotransferase class-I; Region: GATase; pfam00117 246196000153 glutamine binding [chemical binding]; other site 246196000154 catalytic triad [active] 246196000155 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196000156 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196000157 active site 246196000158 ATP binding site [chemical binding]; other site 246196000159 substrate binding site [chemical binding]; other site 246196000160 activation loop (A-loop); other site 246196000161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 246196000162 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196000163 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196000164 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196000165 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196000166 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196000167 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196000168 active site 246196000169 ATP binding site [chemical binding]; other site 246196000170 substrate binding site [chemical binding]; other site 246196000171 activation loop (A-loop); other site 246196000172 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 246196000173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196000174 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 246196000175 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246196000176 active site 246196000177 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196000178 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196000179 phosphopeptide binding site; other site 246196000180 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 246196000181 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196000182 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196000183 phosphopeptide binding site; other site 246196000184 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196000185 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 246196000186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000188 WHG domain; Region: WHG; pfam13305 246196000189 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 246196000190 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 246196000191 putative active site [active] 246196000192 metal binding site [ion binding]; metal-binding site 246196000193 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 246196000194 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196000195 Pirin-related protein [General function prediction only]; Region: COG1741 246196000196 Pirin; Region: Pirin; pfam02678 246196000197 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 246196000198 DivIVA domain; Region: DivI1A_domain; TIGR03544 246196000199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 246196000200 Homeodomain-like domain; Region: HTH_23; pfam13384 246196000201 Winged helix-turn helix; Region: HTH_29; pfam13551 246196000202 Homeodomain-like domain; Region: HTH_32; pfam13565 246196000203 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196000204 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 246196000205 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196000206 EspG family; Region: ESX-1_EspG; pfam14011 246196000207 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 246196000208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196000209 Walker A motif; other site 246196000210 ATP binding site [chemical binding]; other site 246196000211 Walker B motif; other site 246196000212 arginine finger; other site 246196000213 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 246196000214 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 246196000215 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196000216 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 246196000217 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196000218 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196000219 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 246196000220 PPE family; Region: PPE; pfam00823 246196000221 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 246196000222 Proteins of 100 residues with WXG; Region: WXG100; cl02005 246196000223 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 246196000224 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196000225 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196000226 P-loop; other site 246196000227 Magnesium ion binding site [ion binding]; other site 246196000228 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 246196000229 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 246196000230 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196000231 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196000232 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196000233 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 246196000234 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 246196000235 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 246196000236 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 246196000237 active site 246196000238 catalytic residues [active] 246196000239 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 246196000240 dimerization domain swap beta strand [polypeptide binding]; other site 246196000241 regulatory protein interface [polypeptide binding]; other site 246196000242 active site 246196000243 regulatory phosphorylation site [posttranslational modification]; other site 246196000244 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 246196000245 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 246196000246 active site 246196000247 phosphorylation site [posttranslational modification] 246196000248 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 246196000249 active site 246196000250 P-loop; other site 246196000251 phosphorylation site [posttranslational modification] 246196000252 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 246196000253 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 246196000254 putative substrate binding site [chemical binding]; other site 246196000255 putative ATP binding site [chemical binding]; other site 246196000256 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196000257 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 246196000258 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196000259 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 246196000260 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 246196000261 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 246196000262 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246196000263 Pirin-related protein [General function prediction only]; Region: COG1741 246196000264 Pirin; Region: Pirin; pfam02678 246196000265 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 246196000266 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246196000267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000269 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 246196000270 LDH/MDH dimer interface [polypeptide binding]; other site 246196000271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000273 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196000274 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196000275 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196000276 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196000277 short chain dehydrogenase; Provisional; Region: PRK07791 246196000278 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 246196000279 NAD binding site [chemical binding]; other site 246196000280 homodimer interface [polypeptide binding]; other site 246196000281 active site 246196000282 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196000283 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 246196000284 NAD(P) binding site [chemical binding]; other site 246196000285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196000286 S-adenosylmethionine binding site [chemical binding]; other site 246196000287 YceI-like domain; Region: YceI; smart00867 246196000288 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 246196000289 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 246196000290 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 246196000291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000292 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 246196000293 FAD binding site [chemical binding]; other site 246196000294 substrate binding site [chemical binding]; other site 246196000295 catalytic base [active] 246196000296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000297 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196000298 putative substrate translocation pore; other site 246196000299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196000300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196000301 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 246196000302 putative dimerization interface [polypeptide binding]; other site 246196000303 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196000304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196000305 active site 246196000306 phosphorylation site [posttranslational modification] 246196000307 intermolecular recognition site; other site 246196000308 dimerization interface [polypeptide binding]; other site 246196000309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196000310 DNA binding residues [nucleotide binding] 246196000311 dimerization interface [polypeptide binding]; other site 246196000312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196000313 ATP binding site [chemical binding]; other site 246196000314 G-X-G motif; other site 246196000315 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 246196000316 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196000317 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196000319 active site 246196000320 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 246196000321 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 246196000322 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 246196000323 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 246196000324 ligand binding site [chemical binding]; other site 246196000325 homodimer interface [polypeptide binding]; other site 246196000326 NAD(P) binding site [chemical binding]; other site 246196000327 trimer interface B [polypeptide binding]; other site 246196000328 trimer interface A [polypeptide binding]; other site 246196000329 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 246196000330 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 246196000331 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 246196000332 oligomer interface [polypeptide binding]; other site 246196000333 metal binding site [ion binding]; metal-binding site 246196000334 metal binding site [ion binding]; metal-binding site 246196000335 putative Cl binding site [ion binding]; other site 246196000336 aspartate ring; other site 246196000337 basic sphincter; other site 246196000338 hydrophobic gate; other site 246196000339 periplasmic entrance; other site 246196000340 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196000341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196000342 dimer interface [polypeptide binding]; other site 246196000343 conserved gate region; other site 246196000344 putative PBP binding loops; other site 246196000345 ABC-ATPase subunit interface; other site 246196000346 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 246196000347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196000348 substrate binding pocket [chemical binding]; other site 246196000349 membrane-bound complex binding site; other site 246196000350 hinge residues; other site 246196000351 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196000352 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196000353 Walker A/P-loop; other site 246196000354 ATP binding site [chemical binding]; other site 246196000355 Q-loop/lid; other site 246196000356 ABC transporter signature motif; other site 246196000357 Walker B; other site 246196000358 D-loop; other site 246196000359 H-loop/switch region; other site 246196000360 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 246196000361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196000362 active site 246196000363 motif I; other site 246196000364 motif II; other site 246196000365 haloalkane dehalogenase; Provisional; Region: PRK00870 246196000366 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196000367 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196000368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000370 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 246196000371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196000372 NAD(P) binding site [chemical binding]; other site 246196000373 active site 246196000374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 246196000375 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 246196000376 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 246196000377 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196000378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000379 DNA-binding site [nucleotide binding]; DNA binding site 246196000380 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196000381 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 246196000382 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 246196000383 active site pocket [active] 246196000384 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 246196000385 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196000386 NAD(P) binding site [chemical binding]; other site 246196000387 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246196000388 active site 246196000389 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 246196000390 putative hydrophobic ligand binding site [chemical binding]; other site 246196000391 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196000392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000393 DNA-binding site [nucleotide binding]; DNA binding site 246196000394 FCD domain; Region: FCD; pfam07729 246196000395 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 246196000396 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196000397 acyl-activating enzyme (AAE) consensus motif; other site 246196000398 AMP binding site [chemical binding]; other site 246196000399 active site 246196000400 CoA binding site [chemical binding]; other site 246196000401 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196000402 Permease; Region: Permease; pfam02405 246196000403 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196000404 Permease; Region: Permease; pfam02405 246196000405 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000406 mce related protein; Region: MCE; pfam02470 246196000407 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196000408 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000409 mce related protein; Region: MCE; pfam02470 246196000410 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196000411 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000412 mce related protein; Region: MCE; pfam02470 246196000413 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196000414 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000415 mce related protein; Region: MCE; pfam02470 246196000416 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000417 mce related protein; Region: MCE; pfam02470 246196000418 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000419 mce related protein; Region: MCE; pfam02470 246196000420 RDD family; Region: RDD; pfam06271 246196000421 SnoaL-like domain; Region: SnoaL_4; cl17707 246196000422 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 246196000423 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196000424 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196000425 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196000426 active site 246196000427 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 246196000428 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 246196000429 MOSC domain; Region: MOSC; pfam03473 246196000430 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246196000431 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246196000432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000434 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 246196000435 ThiC-associated domain; Region: ThiC-associated; pfam13667 246196000436 ThiC family; Region: ThiC; cl08031 246196000437 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 246196000438 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 246196000439 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 246196000440 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 246196000441 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 246196000442 ligand binding site [chemical binding]; other site 246196000443 homodimer interface [polypeptide binding]; other site 246196000444 NAD(P) binding site [chemical binding]; other site 246196000445 trimer interface B [polypeptide binding]; other site 246196000446 trimer interface A [polypeptide binding]; other site 246196000447 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 246196000448 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 246196000449 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 246196000450 pyruvate kinase; Provisional; Region: PRK06247 246196000451 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 246196000452 domain interfaces; other site 246196000453 active site 246196000454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196000455 PAS domain; Region: PAS_9; pfam13426 246196000456 putative active site [active] 246196000457 heme pocket [chemical binding]; other site 246196000458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196000459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196000460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196000461 dimerization interface [polypeptide binding]; other site 246196000462 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 246196000463 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196000464 PYR/PP interface [polypeptide binding]; other site 246196000465 dimer interface [polypeptide binding]; other site 246196000466 TPP binding site [chemical binding]; other site 246196000467 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196000468 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 246196000469 TPP-binding site; other site 246196000470 dimer interface [polypeptide binding]; other site 246196000471 formyl-coenzyme A transferase; Provisional; Region: PRK05398 246196000472 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196000473 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 246196000474 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 246196000475 putative dimer interface [polypeptide binding]; other site 246196000476 [2Fe-2S] cluster binding site [ion binding]; other site 246196000477 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 246196000478 putative dimer interface [polypeptide binding]; other site 246196000479 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 246196000480 SLBB domain; Region: SLBB; pfam10531 246196000481 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 246196000482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196000483 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 246196000484 catalytic loop [active] 246196000485 iron binding site [ion binding]; other site 246196000486 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 246196000487 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 246196000488 [4Fe-4S] binding site [ion binding]; other site 246196000489 molybdopterin cofactor binding site; other site 246196000490 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 246196000491 molybdopterin cofactor binding site; other site 246196000492 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 246196000493 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196000494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000495 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 246196000496 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196000497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000498 DNA-binding site [nucleotide binding]; DNA binding site 246196000499 FCD domain; Region: FCD; pfam07729 246196000500 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196000501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000502 formyl-coenzyme A transferase; Provisional; Region: PRK05398 246196000503 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196000504 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196000505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000506 putative substrate translocation pore; other site 246196000507 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 246196000508 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 246196000509 putative active site [active] 246196000510 Zn binding site [ion binding]; other site 246196000511 Domain of unknown function (DUF202); Region: DUF202; cl09954 246196000512 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196000513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196000514 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196000515 substrate binding pocket [chemical binding]; other site 246196000516 membrane-bound complex binding site; other site 246196000517 hinge residues; other site 246196000518 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246196000519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196000520 dimer interface [polypeptide binding]; other site 246196000521 conserved gate region; other site 246196000522 putative PBP binding loops; other site 246196000523 ABC-ATPase subunit interface; other site 246196000524 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196000525 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196000526 Walker A/P-loop; other site 246196000527 ATP binding site [chemical binding]; other site 246196000528 Q-loop/lid; other site 246196000529 ABC transporter signature motif; other site 246196000530 Walker B; other site 246196000531 D-loop; other site 246196000532 H-loop/switch region; other site 246196000533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196000534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000535 DNA-binding site [nucleotide binding]; DNA binding site 246196000536 FCD domain; Region: FCD; pfam07729 246196000537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000538 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 246196000539 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 246196000540 substrate binding pocket [chemical binding]; other site 246196000541 active site 246196000542 iron coordination sites [ion binding]; other site 246196000543 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196000544 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196000545 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 246196000546 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 246196000547 Transport protein; Region: actII; TIGR00833 246196000548 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196000549 MarR family; Region: MarR; pfam01047 246196000550 putative acetyltransferase; Provisional; Region: PRK03624 246196000551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196000552 Coenzyme A binding pocket [chemical binding]; other site 246196000553 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 246196000554 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 246196000555 Na binding site [ion binding]; other site 246196000556 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246196000557 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 246196000558 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 246196000559 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 246196000560 putative active site [active] 246196000561 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 246196000562 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 246196000563 putative active site [active] 246196000564 Cutinase; Region: Cutinase; pfam01083 246196000565 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196000566 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196000567 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196000568 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196000569 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196000570 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 246196000571 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 246196000572 nudix motif; other site 246196000573 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196000574 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000575 active site 246196000576 Fructosamine kinase; Region: Fructosamin_kin; cl17579 246196000577 Phosphotransferase enzyme family; Region: APH; pfam01636 246196000578 PE-PPE domain; Region: PE-PPE; pfam08237 246196000579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196000580 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196000581 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196000582 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 246196000583 MarR family; Region: MarR_2; cl17246 246196000584 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196000585 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196000586 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 246196000587 active site 246196000588 barstar interaction site; other site 246196000589 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 246196000590 putative RNAase interaction site [polypeptide binding]; other site 246196000591 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 246196000592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000593 Walker A/P-loop; other site 246196000594 ATP binding site [chemical binding]; other site 246196000595 Q-loop/lid; other site 246196000596 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246196000597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000598 Walker A/P-loop; other site 246196000599 ATP binding site [chemical binding]; other site 246196000600 Q-loop/lid; other site 246196000601 ABC transporter; Region: ABC_tran; pfam00005 246196000602 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196000603 ABC transporter signature motif; other site 246196000604 Walker B; other site 246196000605 D-loop; other site 246196000606 H-loop/switch region; other site 246196000607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196000608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 246196000609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196000610 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196000611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196000612 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 246196000613 Pirin-related protein [General function prediction only]; Region: COG1741 246196000614 Pirin; Region: Pirin; pfam02678 246196000615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196000616 NAD(P) binding site [chemical binding]; other site 246196000617 active site 246196000618 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 246196000619 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196000620 NAD binding site [chemical binding]; other site 246196000621 catalytic Zn binding site [ion binding]; other site 246196000622 substrate binding site [chemical binding]; other site 246196000623 structural Zn binding site [ion binding]; other site 246196000624 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 246196000625 dimer interface [polypeptide binding]; other site 246196000626 RNA polymerase factor sigma-70; Validated; Region: PRK08241 246196000627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196000628 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196000629 DNA binding residues [nucleotide binding] 246196000630 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 246196000631 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246196000632 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196000633 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196000634 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 246196000635 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 246196000636 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 246196000637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196000638 S-adenosylmethionine binding site [chemical binding]; other site 246196000639 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196000640 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196000641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000643 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 246196000644 Double zinc ribbon; Region: DZR; pfam12773 246196000645 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196000646 cyclase homology domain; Region: CHD; cd07302 246196000647 nucleotidyl binding site; other site 246196000648 metal binding site [ion binding]; metal-binding site 246196000649 dimer interface [polypeptide binding]; other site 246196000650 Predicted ATPase [General function prediction only]; Region: COG3899 246196000651 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 246196000652 6-phosphogluconate dehydratase; Region: edd; TIGR01196 246196000653 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 246196000654 putative homotetramer interface [polypeptide binding]; other site 246196000655 putative homodimer interface [polypeptide binding]; other site 246196000656 putative allosteric switch controlling residues; other site 246196000657 putative metal binding site [ion binding]; other site 246196000658 putative homodimer-homodimer interface [polypeptide binding]; other site 246196000659 Domain of unknown function DUF77; Region: DUF77; pfam01910 246196000660 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196000661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000662 putative substrate translocation pore; other site 246196000663 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 246196000664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196000665 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196000666 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 246196000667 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 246196000668 active site 246196000669 Zn binding site [ion binding]; other site 246196000670 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196000671 CoA binding domain; Region: CoA_binding; cl17356 246196000672 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 246196000673 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246196000674 homodimer interface [polypeptide binding]; other site 246196000675 substrate-cofactor binding pocket; other site 246196000676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196000677 catalytic residue [active] 246196000678 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196000679 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 246196000680 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196000681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196000682 active site 246196000683 phosphorylation site [posttranslational modification] 246196000684 intermolecular recognition site; other site 246196000685 dimerization interface [polypeptide binding]; other site 246196000686 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196000687 DNA binding site [nucleotide binding] 246196000688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196000689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196000690 phosphorylation site [posttranslational modification] 246196000691 dimer interface [polypeptide binding]; other site 246196000692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196000693 ATP binding site [chemical binding]; other site 246196000694 Mg2+ binding site [ion binding]; other site 246196000695 G-X-G motif; other site 246196000696 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 246196000697 Peptidase family M23; Region: Peptidase_M23; pfam01551 246196000698 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246196000699 Predicted integral membrane protein [Function unknown]; Region: COG0392 246196000700 Domain of unknown function DUF20; Region: UPF0118; pfam01594 246196000701 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246196000702 MMPL family; Region: MMPL; pfam03176 246196000703 MMPL family; Region: MMPL; pfam03176 246196000704 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 246196000705 LabA_like proteins; Region: LabA_like; cd06167 246196000706 putative metal binding site [ion binding]; other site 246196000707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196000708 S-adenosylmethionine binding site [chemical binding]; other site 246196000709 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246196000710 Switch II region; other site 246196000711 G4 box; other site 246196000712 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 246196000713 active site 246196000714 substrate-binding site [chemical binding]; other site 246196000715 metal-binding site [ion binding] 246196000716 GTP binding site [chemical binding]; other site 246196000717 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 246196000718 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196000719 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196000720 acyl-activating enzyme (AAE) consensus motif; other site 246196000721 acyl-activating enzyme (AAE) consensus motif; other site 246196000722 putative AMP binding site [chemical binding]; other site 246196000723 putative active site [active] 246196000724 putative CoA binding site [chemical binding]; other site 246196000725 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196000726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196000727 substrate binding site [chemical binding]; other site 246196000728 oxyanion hole (OAH) forming residues; other site 246196000729 trimer interface [polypeptide binding]; other site 246196000730 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196000731 classical (c) SDRs; Region: SDR_c; cd05233 246196000732 NAD(P) binding site [chemical binding]; other site 246196000733 active site 246196000734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196000735 salt bridge; other site 246196000736 non-specific DNA binding site [nucleotide binding]; other site 246196000737 sequence-specific DNA binding site [nucleotide binding]; other site 246196000738 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 246196000739 putative active site [active] 246196000740 putative catalytic site [active] 246196000741 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196000742 active site 2 [active] 246196000743 active site 1 [active] 246196000744 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196000745 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196000746 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196000747 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196000748 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196000749 active site 246196000750 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 246196000751 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 246196000752 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196000753 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196000754 catalytic residue [active] 246196000755 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 246196000756 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 246196000757 Fe-S cluster binding site [ion binding]; other site 246196000758 active site 246196000759 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196000760 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196000761 substrate binding pocket [chemical binding]; other site 246196000762 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196000763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000764 DNA-binding site [nucleotide binding]; DNA binding site 246196000765 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196000766 UTRA domain; Region: UTRA; pfam07702 246196000767 short chain dehydrogenase; Provisional; Region: PRK12829 246196000768 classical (c) SDRs; Region: SDR_c; cd05233 246196000769 NAD(P) binding site [chemical binding]; other site 246196000770 active site 246196000771 Phosphotransferase enzyme family; Region: APH; pfam01636 246196000772 Fructosamine kinase; Region: Fructosamin_kin; cl17579 246196000773 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 246196000774 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 246196000775 putative hexamer interface [polypeptide binding]; other site 246196000776 putative hexagonal pore; other site 246196000777 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 246196000778 putative hexamer interface [polypeptide binding]; other site 246196000779 putative hexagonal pore; other site 246196000780 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 246196000781 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 246196000782 Hexamer interface [polypeptide binding]; other site 246196000783 Hexagonal pore residue; other site 246196000784 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 246196000785 Hexamer/Pentamer interface [polypeptide binding]; other site 246196000786 central pore; other site 246196000787 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 246196000788 putative hexamer interface [polypeptide binding]; other site 246196000789 putative hexagonal pore; other site 246196000790 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 246196000791 putative hexamer interface [polypeptide binding]; other site 246196000792 putative hexagonal pore; other site 246196000793 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196000794 NAD(P) binding site [chemical binding]; other site 246196000795 catalytic residues [active] 246196000796 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 246196000797 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196000798 inhibitor-cofactor binding pocket; inhibition site 246196000799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196000800 catalytic residue [active] 246196000801 Amino acid permease; Region: AA_permease_2; pfam13520 246196000802 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196000803 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196000804 choline dehydrogenase; Validated; Region: PRK02106 246196000805 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196000806 EthD domain; Region: EthD; cl17553 246196000807 short chain dehydrogenase; Provisional; Region: PRK06523 246196000808 classical (c) SDRs; Region: SDR_c; cd05233 246196000809 NAD(P) binding site [chemical binding]; other site 246196000810 active site 246196000811 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 246196000812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000814 transcriptional regulator protein; Region: phnR; TIGR03337 246196000815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000816 DNA-binding site [nucleotide binding]; DNA binding site 246196000817 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 246196000818 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 246196000819 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 246196000820 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246196000821 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196000822 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196000823 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196000824 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196000825 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196000826 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246196000827 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 246196000828 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 246196000829 substrate binding pocket [chemical binding]; other site 246196000830 active site 246196000831 iron coordination sites [ion binding]; other site 246196000832 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196000833 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196000834 [2Fe-2S] cluster binding site [ion binding]; other site 246196000835 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 246196000836 alpha subunit interface [polypeptide binding]; other site 246196000837 active site 246196000838 substrate binding site [chemical binding]; other site 246196000839 Fe binding site [ion binding]; other site 246196000840 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196000841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196000842 NAD(P) binding site [chemical binding]; other site 246196000843 active site 246196000844 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 246196000845 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 246196000846 FAD binding pocket [chemical binding]; other site 246196000847 FAD binding motif [chemical binding]; other site 246196000848 phosphate binding motif [ion binding]; other site 246196000849 beta-alpha-beta structure motif; other site 246196000850 NAD(p) ribose binding residues [chemical binding]; other site 246196000851 NAD binding pocket [chemical binding]; other site 246196000852 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 246196000853 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196000854 catalytic loop [active] 246196000855 iron binding site [ion binding]; other site 246196000856 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196000857 MarR family; Region: MarR_2; pfam12802 246196000858 MarR family; Region: MarR_2; cl17246 246196000859 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196000860 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 246196000861 active site 246196000862 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196000863 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196000864 [2Fe-2S] cluster binding site [ion binding]; other site 246196000865 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 246196000866 alpha subunit interface [polypeptide binding]; other site 246196000867 active site 246196000868 substrate binding site [chemical binding]; other site 246196000869 Fe binding site [ion binding]; other site 246196000870 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196000871 FAD binding domain; Region: FAD_binding_4; pfam01565 246196000872 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246196000873 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 246196000874 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196000875 putative NAD(P) binding site [chemical binding]; other site 246196000876 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196000877 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196000878 acyl-CoA synthetase; Provisional; Region: PRK13382 246196000879 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196000880 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196000881 acyl-activating enzyme (AAE) consensus motif; other site 246196000882 putative AMP binding site [chemical binding]; other site 246196000883 putative active site [active] 246196000884 putative CoA binding site [chemical binding]; other site 246196000885 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246196000886 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 246196000887 putative acyl-acceptor binding pocket; other site 246196000888 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 246196000889 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196000890 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246196000891 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 246196000892 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196000893 NAD binding site [chemical binding]; other site 246196000894 catalytic residues [active] 246196000895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196000896 S-adenosylmethionine binding site [chemical binding]; other site 246196000897 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196000898 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196000899 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 246196000900 active site 246196000901 intersubunit interface [polypeptide binding]; other site 246196000902 catalytic residue [active] 246196000903 phosphogluconate dehydratase; Validated; Region: PRK09054 246196000904 6-phosphogluconate dehydratase; Region: edd; TIGR01196 246196000905 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 246196000906 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 246196000907 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 246196000908 putative DNA binding site [nucleotide binding]; other site 246196000909 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 246196000910 putative Zn2+ binding site [ion binding]; other site 246196000911 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196000912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196000913 nucleotide binding site [chemical binding]; other site 246196000914 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 246196000915 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196000916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196000917 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 246196000918 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196000919 putative AMP binding site [chemical binding]; other site 246196000920 putative active site [active] 246196000921 acyl-activating enzyme (AAE) consensus motif; other site 246196000922 putative CoA binding site [chemical binding]; other site 246196000923 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 246196000924 active site 246196000925 substrate binding pocket [chemical binding]; other site 246196000926 homodimer interaction site [polypeptide binding]; other site 246196000927 AAA ATPase domain; Region: AAA_16; pfam13191 246196000928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196000929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196000930 DNA binding residues [nucleotide binding] 246196000931 dimerization interface [polypeptide binding]; other site 246196000932 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000933 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196000934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196000935 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 246196000936 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 246196000937 acyl-CoA synthetase; Validated; Region: PRK06188 246196000938 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196000939 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196000940 acyl-activating enzyme (AAE) consensus motif; other site 246196000941 acyl-activating enzyme (AAE) consensus motif; other site 246196000942 putative AMP binding site [chemical binding]; other site 246196000943 putative active site [active] 246196000944 putative CoA binding site [chemical binding]; other site 246196000945 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196000946 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196000947 NAD(P) binding site [chemical binding]; other site 246196000948 catalytic residues [active] 246196000949 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 246196000950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196000951 GAF domain; Region: GAF; cl17456 246196000952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196000953 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196000954 DNA binding residues [nucleotide binding] 246196000955 dimerization interface [polypeptide binding]; other site 246196000956 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196000957 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246196000958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196000959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196000960 DNA binding residues [nucleotide binding] 246196000961 dimerization interface [polypeptide binding]; other site 246196000962 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 246196000963 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196000964 FMN binding site [chemical binding]; other site 246196000965 substrate binding site [chemical binding]; other site 246196000966 putative catalytic residue [active] 246196000967 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 246196000968 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196000969 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 246196000970 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196000971 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196000972 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196000973 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196000974 carboxyltransferase (CT) interaction site; other site 246196000975 biotinylation site [posttranslational modification]; other site 246196000976 enoyl-CoA hydratase; Provisional; Region: PRK08252 246196000977 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196000978 substrate binding site [chemical binding]; other site 246196000979 oxyanion hole (OAH) forming residues; other site 246196000980 trimer interface [polypeptide binding]; other site 246196000981 TIGR03084 family protein; Region: TIGR03084 246196000982 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196000983 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 246196000984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000985 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196000986 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196000987 active site 246196000988 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196000989 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 246196000990 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196000991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196000992 substrate binding site [chemical binding]; other site 246196000993 oxyanion hole (OAH) forming residues; other site 246196000994 trimer interface [polypeptide binding]; other site 246196000995 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 246196000996 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196000997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000999 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196001000 Permease; Region: Permease; pfam02405 246196001001 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196001002 Permease; Region: Permease; pfam02405 246196001003 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001004 mce related protein; Region: MCE; pfam02470 246196001005 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196001006 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001007 mce related protein; Region: MCE; pfam02470 246196001008 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001009 mce related protein; Region: MCE; pfam02470 246196001010 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001011 mce related protein; Region: MCE; pfam02470 246196001012 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001013 mce related protein; Region: MCE; pfam02470 246196001014 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196001015 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001016 mce related protein; Region: MCE; pfam02470 246196001017 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196001018 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 246196001019 Predicted acetyltransferase [General function prediction only]; Region: COG2388 246196001020 Transmembrane secretion effector; Region: MFS_3; pfam05977 246196001021 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 246196001022 active site 246196001023 diiron metal binding site [ion binding]; other site 246196001024 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 246196001025 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 246196001026 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 246196001027 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 246196001028 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 246196001029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196001030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001032 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 246196001033 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 246196001034 O-methyltransferase; Region: Methyltransf_2; pfam00891 246196001035 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 246196001036 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 246196001037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 246196001038 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 246196001039 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 246196001040 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196001041 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196001042 active site 2 [active] 246196001043 active site 1 [active] 246196001044 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 246196001045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001046 NAD(P) binding site [chemical binding]; other site 246196001047 active site 246196001048 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 246196001049 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196001050 dimer interface [polypeptide binding]; other site 246196001051 active site 246196001052 FAD binding domain; Region: FAD_binding_4; pfam01565 246196001053 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246196001054 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196001055 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 246196001056 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246196001057 putative active site [active] 246196001058 catalytic site [active] 246196001059 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 246196001060 putative active site [active] 246196001061 catalytic site [active] 246196001062 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246196001063 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196001064 conserved cys residue [active] 246196001065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196001066 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 246196001067 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 246196001068 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 246196001069 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 246196001070 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 246196001071 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 246196001072 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196001073 Transport protein; Region: actII; TIGR00833 246196001074 Phosphate transporter family; Region: PHO4; cl00396 246196001075 Transport protein; Region: actII; TIGR00833 246196001076 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 246196001077 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 246196001078 substrate binding site; other site 246196001079 tetramer interface; other site 246196001080 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196001081 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196001082 homodimer interface [polypeptide binding]; other site 246196001083 active site 246196001084 TDP-binding site; other site 246196001085 acceptor substrate-binding pocket; other site 246196001086 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196001087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001088 NAD(P) binding site [chemical binding]; other site 246196001089 active site 246196001090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196001091 S-adenosylmethionine binding site [chemical binding]; other site 246196001092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196001093 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196001094 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196001095 homodimer interface [polypeptide binding]; other site 246196001096 active site 246196001097 TDP-binding site; other site 246196001098 acceptor substrate-binding pocket; other site 246196001099 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246196001100 Methyltransferase domain; Region: Methyltransf_24; pfam13578 246196001101 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196001102 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196001103 homodimer interface [polypeptide binding]; other site 246196001104 active site 246196001105 TDP-binding site; other site 246196001106 acceptor substrate-binding pocket; other site 246196001107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196001108 S-adenosylmethionine binding site [chemical binding]; other site 246196001109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196001110 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196001111 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196001112 MbtH-like protein; Region: MbtH; pfam03621 246196001113 Condensation domain; Region: Condensation; pfam00668 246196001114 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196001115 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246196001116 acyl-activating enzyme (AAE) consensus motif; other site 246196001117 AMP binding site [chemical binding]; other site 246196001118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196001119 Condensation domain; Region: Condensation; pfam00668 246196001120 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196001121 Condensation domain; Region: Condensation; pfam00668 246196001122 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196001123 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196001124 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196001125 acyl-activating enzyme (AAE) consensus motif; other site 246196001126 AMP binding site [chemical binding]; other site 246196001127 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196001128 Condensation domain; Region: Condensation; pfam00668 246196001129 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196001130 Condensation domain; Region: Condensation; pfam00668 246196001131 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196001132 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196001133 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196001134 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246196001135 acyl-activating enzyme (AAE) consensus motif; other site 246196001136 AMP binding site [chemical binding]; other site 246196001137 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196001138 Condensation domain; Region: Condensation; pfam00668 246196001139 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196001140 Condensation domain; Region: Condensation; pfam00668 246196001141 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196001142 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196001143 acyl-activating enzyme (AAE) consensus motif; other site 246196001144 AMP binding site [chemical binding]; other site 246196001145 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196001146 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246196001147 putative NAD(P) binding site [chemical binding]; other site 246196001148 active site 246196001149 putative substrate binding site [chemical binding]; other site 246196001150 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196001151 YCII-related domain; Region: YCII; cl00999 246196001152 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 246196001153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196001154 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196001155 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 246196001156 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 246196001157 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 246196001158 FAD binding site [chemical binding]; other site 246196001159 substrate binding site [chemical binding]; other site 246196001160 catalytic residues [active] 246196001161 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 246196001162 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196001163 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196001164 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246196001165 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196001166 active site 246196001167 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246196001168 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196001169 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 246196001170 KR domain; Region: KR; pfam08659 246196001171 NADP binding site [chemical binding]; other site 246196001172 active site 246196001173 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196001174 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246196001175 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196001176 active site 246196001177 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196001178 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246196001179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001180 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 246196001181 Enoylreductase; Region: PKS_ER; smart00829 246196001182 NAD(P) binding site [chemical binding]; other site 246196001183 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246196001184 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246196001185 putative NADP binding site [chemical binding]; other site 246196001186 active site 246196001187 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196001188 Transport protein; Region: actII; TIGR00833 246196001189 acyl-CoA synthetase; Validated; Region: PRK05850 246196001190 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196001191 acyl-activating enzyme (AAE) consensus motif; other site 246196001192 active site 246196001193 PE-PPE domain; Region: PE-PPE; pfam08237 246196001194 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196001195 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196001196 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196001197 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196001198 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 246196001199 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 246196001200 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196001201 catalytic loop [active] 246196001202 iron binding site [ion binding]; other site 246196001203 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 246196001204 L-aspartate oxidase; Provisional; Region: PRK06175 246196001205 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196001206 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196001207 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 246196001208 tetramer interface [polypeptide binding]; other site 246196001209 active site 246196001210 Mg2+/Mn2+ binding site [ion binding]; other site 246196001211 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246196001212 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246196001213 putative dimer interface [polypeptide binding]; other site 246196001214 EamA-like transporter family; Region: EamA; pfam00892 246196001215 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196001216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001217 DNA-binding site [nucleotide binding]; DNA binding site 246196001218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196001219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196001220 homodimer interface [polypeptide binding]; other site 246196001221 catalytic residue [active] 246196001222 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 246196001223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196001224 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 246196001225 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196001226 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 246196001227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196001228 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196001229 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 246196001230 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 246196001231 putative active site [active] 246196001232 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 246196001233 putative active site [active] 246196001234 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 246196001235 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 246196001236 active site 246196001237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 246196001238 DNA binding site [nucleotide binding] 246196001239 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 246196001240 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 246196001241 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 246196001242 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 246196001243 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 246196001244 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 246196001245 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196001246 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246196001247 intersubunit interface [polypeptide binding]; other site 246196001248 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 246196001249 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196001250 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196001251 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 246196001252 tetracycline repressor protein TetR; Provisional; Region: PRK13756 246196001253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001254 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196001255 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 246196001256 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196001257 active site 246196001258 catalytic triad [active] 246196001259 dimer interface [polypeptide binding]; other site 246196001260 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 246196001261 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 246196001262 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196001263 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 246196001264 active site 246196001265 amino acid transporter; Region: 2A0306; TIGR00909 246196001266 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 246196001267 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196001268 MarR family; Region: MarR; pfam01047 246196001269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196001271 putative substrate translocation pore; other site 246196001272 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196001273 Ligand Binding Site [chemical binding]; other site 246196001274 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 246196001275 fructuronate transporter; Provisional; Region: PRK10034; cl15264 246196001276 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 246196001277 AAA domain; Region: AAA_33; pfam13671 246196001278 ATP-binding site [chemical binding]; other site 246196001279 Gluconate-6-phosphate binding site [chemical binding]; other site 246196001280 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196001281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196001282 DNA-binding site [nucleotide binding]; DNA binding site 246196001283 FCD domain; Region: FCD; pfam07729 246196001284 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 246196001285 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196001286 NAD binding site [chemical binding]; other site 246196001287 catalytic residues [active] 246196001288 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 246196001289 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 246196001290 CAP-like domain; other site 246196001291 active site 246196001292 primary dimer interface [polypeptide binding]; other site 246196001293 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196001294 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 246196001295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196001296 Mg2+ binding site [ion binding]; other site 246196001297 G-X-G motif; other site 246196001298 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 246196001299 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 246196001300 active site 246196001301 metal binding site [ion binding]; metal-binding site 246196001302 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246196001303 Putative sensor; Region: Sensor; pfam13796 246196001304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196001305 Histidine kinase; Region: HisKA_3; pfam07730 246196001306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196001307 ATP binding site [chemical binding]; other site 246196001308 Mg2+ binding site [ion binding]; other site 246196001309 G-X-G motif; other site 246196001310 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196001311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196001312 active site 246196001313 phosphorylation site [posttranslational modification] 246196001314 intermolecular recognition site; other site 246196001315 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196001316 dimerization interface [polypeptide binding]; other site 246196001317 DNA binding residues [nucleotide binding] 246196001318 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196001319 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196001320 Uncharacterized conserved protein [Function unknown]; Region: COG1739 246196001321 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 246196001322 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 246196001323 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196001324 Transport protein; Region: actII; TIGR00833 246196001325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001327 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 246196001328 substrate binding site [chemical binding]; other site 246196001329 dimer interface [polypeptide binding]; other site 246196001330 ATP binding site [chemical binding]; other site 246196001331 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 246196001332 Lysine efflux permease [General function prediction only]; Region: COG1279 246196001333 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196001334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196001335 putative Zn2+ binding site [ion binding]; other site 246196001336 putative DNA binding site [nucleotide binding]; other site 246196001337 dimerization interface [polypeptide binding]; other site 246196001338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 246196001339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196001340 Coenzyme A binding pocket [chemical binding]; other site 246196001341 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 246196001342 EamA-like transporter family; Region: EamA; pfam00892 246196001343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196001344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196001345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196001346 dimerization interface [polypeptide binding]; other site 246196001347 Carboxylesterase family; Region: COesterase; pfam00135 246196001348 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196001349 substrate binding pocket [chemical binding]; other site 246196001350 catalytic triad [active] 246196001351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196001352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 246196001353 active site 246196001354 intermolecular recognition site; other site 246196001355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196001356 DNA binding residues [nucleotide binding] 246196001357 dimerization interface [polypeptide binding]; other site 246196001358 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246196001359 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246196001360 glutaminase active site [active] 246196001361 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196001362 dimer interface [polypeptide binding]; other site 246196001363 active site 246196001364 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246196001365 dimer interface [polypeptide binding]; other site 246196001366 active site 246196001367 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 246196001368 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 246196001369 NAD binding site [chemical binding]; other site 246196001370 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246196001371 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246196001372 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 246196001373 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 246196001374 DXD motif; other site 246196001375 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 246196001376 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 246196001377 putative active site [active] 246196001378 putative metal binding site [ion binding]; other site 246196001379 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196001380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001381 DNA-binding site [nucleotide binding]; DNA binding site 246196001382 FCD domain; Region: FCD; pfam07729 246196001383 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 246196001384 Dehydratase family; Region: ILVD_EDD; pfam00920 246196001385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001386 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196001387 putative substrate translocation pore; other site 246196001388 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 246196001389 amidase; Provisional; Region: PRK07235 246196001390 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196001391 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 246196001392 NMT1/THI5 like; Region: NMT1; pfam09084 246196001393 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196001394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 246196001395 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196001396 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196001397 Walker A/P-loop; other site 246196001398 ATP binding site [chemical binding]; other site 246196001399 Q-loop/lid; other site 246196001400 ABC transporter signature motif; other site 246196001401 Walker B; other site 246196001402 D-loop; other site 246196001403 H-loop/switch region; other site 246196001404 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196001405 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196001406 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196001407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196001408 substrate binding site [chemical binding]; other site 246196001409 oxyanion hole (OAH) forming residues; other site 246196001410 trimer interface [polypeptide binding]; other site 246196001411 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196001412 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196001413 DNA binding site [nucleotide binding] 246196001414 domain linker motif; other site 246196001415 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196001416 dimerization interface [polypeptide binding]; other site 246196001417 ligand binding site [chemical binding]; other site 246196001418 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 246196001419 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 246196001420 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 246196001421 Dehydratase large subunit; Region: Dehydratase_LU; pfam02286 246196001422 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 246196001423 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 246196001424 alpha-beta subunit interface [polypeptide binding]; other site 246196001425 alpha-gamma subunit interface [polypeptide binding]; other site 246196001426 active site 246196001427 substrate and K+ binding site; other site 246196001428 K+ binding site [ion binding]; other site 246196001429 cobalamin binding site [chemical binding]; other site 246196001430 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 246196001431 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196001432 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196001433 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196001434 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 246196001435 active site 246196001436 trimer interface [polypeptide binding]; other site 246196001437 allosteric site; other site 246196001438 active site lid [active] 246196001439 hexamer (dimer of trimers) interface [polypeptide binding]; other site 246196001440 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 246196001441 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 246196001442 NAD binding site [chemical binding]; other site 246196001443 sugar binding site [chemical binding]; other site 246196001444 divalent metal binding site [ion binding]; other site 246196001445 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246196001446 dimer interface [polypeptide binding]; other site 246196001447 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196001448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196001449 putative DNA binding site [nucleotide binding]; other site 246196001450 putative Zn2+ binding site [ion binding]; other site 246196001451 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196001452 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196001453 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246196001454 substrate binding site [chemical binding]; other site 246196001455 ATP binding site [chemical binding]; other site 246196001456 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196001457 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196001458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001459 dimer interface [polypeptide binding]; other site 246196001460 putative PBP binding loops; other site 246196001461 ABC-ATPase subunit interface; other site 246196001462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196001463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001464 dimer interface [polypeptide binding]; other site 246196001465 conserved gate region; other site 246196001466 putative PBP binding loops; other site 246196001467 ABC-ATPase subunit interface; other site 246196001468 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196001469 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246196001470 Walker A/P-loop; other site 246196001471 ATP binding site [chemical binding]; other site 246196001472 Q-loop/lid; other site 246196001473 ABC transporter signature motif; other site 246196001474 Walker B; other site 246196001475 D-loop; other site 246196001476 H-loop/switch region; other site 246196001477 TOBE domain; Region: TOBE_2; pfam08402 246196001478 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196001479 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 246196001480 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196001481 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 246196001482 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 246196001483 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196001484 dimer interface [polypeptide binding]; other site 246196001485 active site 246196001486 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 246196001487 putative active site [active] 246196001488 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196001489 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196001490 nucleotide binding site [chemical binding]; other site 246196001491 alpha-galactosidase; Provisional; Region: PRK15076 246196001492 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 246196001493 NAD binding site [chemical binding]; other site 246196001494 sugar binding site [chemical binding]; other site 246196001495 divalent metal binding site [ion binding]; other site 246196001496 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 246196001497 dimer interface [polypeptide binding]; other site 246196001498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196001499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196001500 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196001501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001502 dimer interface [polypeptide binding]; other site 246196001503 conserved gate region; other site 246196001504 putative PBP binding loops; other site 246196001505 ABC-ATPase subunit interface; other site 246196001506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196001507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001508 dimer interface [polypeptide binding]; other site 246196001509 conserved gate region; other site 246196001510 putative PBP binding loops; other site 246196001511 ABC-ATPase subunit interface; other site 246196001512 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196001513 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246196001514 Walker A/P-loop; other site 246196001515 ATP binding site [chemical binding]; other site 246196001516 Q-loop/lid; other site 246196001517 ABC transporter signature motif; other site 246196001518 Walker B; other site 246196001519 D-loop; other site 246196001520 H-loop/switch region; other site 246196001521 TOBE domain; Region: TOBE_2; pfam08402 246196001522 MspA; Region: MspA; pfam09203 246196001523 short chain dehydrogenase; Provisional; Region: PRK06180 246196001524 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196001525 NADP binding site [chemical binding]; other site 246196001526 active site 246196001527 steroid binding site; other site 246196001528 choline dehydrogenase; Validated; Region: PRK02106 246196001529 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196001530 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196001531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001532 NAD(P) binding site [chemical binding]; other site 246196001533 active site 246196001534 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196001535 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 246196001536 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196001537 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196001538 active site 246196001539 ATP binding site [chemical binding]; other site 246196001540 substrate binding site [chemical binding]; other site 246196001541 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196001542 substrate binding site [chemical binding]; other site 246196001543 activation loop (A-loop); other site 246196001544 activation loop (A-loop); other site 246196001545 AAA ATPase domain; Region: AAA_16; pfam13191 246196001546 AAA domain; Region: AAA_22; pfam13401 246196001547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246196001548 TPR motif; other site 246196001549 binding surface 246196001550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246196001551 short chain dehydrogenase; Provisional; Region: PRK07806 246196001552 NAD(P) binding site [chemical binding]; other site 246196001553 active site 246196001554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196001556 active site 246196001557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001559 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 246196001560 amidase catalytic site [active] 246196001561 substrate binding site [chemical binding]; other site 246196001562 Zn binding residues [ion binding]; other site 246196001563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196001565 putative substrate translocation pore; other site 246196001566 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196001567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196001568 FCD domain; Region: FCD; pfam07729 246196001569 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 246196001570 intracellular protease, PfpI family; Region: PfpI; TIGR01382 246196001571 proposed catalytic triad [active] 246196001572 conserved cys residue [active] 246196001573 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196001574 MarR family; Region: MarR; pfam01047 246196001575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196001576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196001577 ligand binding site [chemical binding]; other site 246196001578 flexible hinge region; other site 246196001579 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 246196001580 putative switch regulator; other site 246196001581 non-specific DNA interactions [nucleotide binding]; other site 246196001582 DNA binding site [nucleotide binding] 246196001583 sequence specific DNA binding site [nucleotide binding]; other site 246196001584 putative cAMP binding site [chemical binding]; other site 246196001585 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 246196001586 PAS fold; Region: PAS_3; pfam08447 246196001587 ANTAR domain; Region: ANTAR; pfam03861 246196001588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196001589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196001590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196001591 dimerization interface [polypeptide binding]; other site 246196001592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196001593 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196001594 cyclase homology domain; Region: CHD; cd07302 246196001595 metal binding site [ion binding]; metal-binding site 246196001596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196001597 S-adenosylmethionine binding site [chemical binding]; other site 246196001598 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 246196001599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196001600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196001601 dimerization interface [polypeptide binding]; other site 246196001602 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196001603 Winged helix-turn helix; Region: HTH_29; pfam13551 246196001604 Homeodomain-like domain; Region: HTH_32; pfam13565 246196001605 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196001606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 246196001607 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196001608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001609 dimer interface [polypeptide binding]; other site 246196001610 conserved gate region; other site 246196001611 putative PBP binding loops; other site 246196001612 ABC-ATPase subunit interface; other site 246196001613 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196001614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196001615 substrate binding pocket [chemical binding]; other site 246196001616 membrane-bound complex binding site; other site 246196001617 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196001618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196001619 Walker A/P-loop; other site 246196001620 ATP binding site [chemical binding]; other site 246196001621 Q-loop/lid; other site 246196001622 ABC transporter signature motif; other site 246196001623 Walker B; other site 246196001624 D-loop; other site 246196001625 H-loop/switch region; other site 246196001626 OsmC-like protein; Region: OsmC; cl00767 246196001627 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196001628 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196001629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001630 putative PBP binding loops; other site 246196001631 dimer interface [polypeptide binding]; other site 246196001632 ABC-ATPase subunit interface; other site 246196001633 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196001634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001635 dimer interface [polypeptide binding]; other site 246196001636 conserved gate region; other site 246196001637 putative PBP binding loops; other site 246196001638 ABC-ATPase subunit interface; other site 246196001639 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 246196001640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196001641 Walker A/P-loop; other site 246196001642 ATP binding site [chemical binding]; other site 246196001643 Q-loop/lid; other site 246196001644 ABC transporter signature motif; other site 246196001645 Walker B; other site 246196001646 D-loop; other site 246196001647 H-loop/switch region; other site 246196001648 TOBE domain; Region: TOBE_2; pfam08402 246196001649 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246196001650 DNA-binding site [nucleotide binding]; DNA binding site 246196001651 RNA-binding motif; other site 246196001652 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196001653 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196001654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001656 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196001657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 246196001658 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 246196001659 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 246196001660 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196001661 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 246196001662 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196001663 active site 246196001664 catalytic triad [active] 246196001665 dimer interface [polypeptide binding]; other site 246196001666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196001667 Coenzyme A binding pocket [chemical binding]; other site 246196001668 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 246196001669 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 246196001670 dimerization interface [polypeptide binding]; other site 246196001671 ATP binding site [chemical binding]; other site 246196001672 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 246196001673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196001674 FeS/SAM binding site; other site 246196001675 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 246196001676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196001677 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 246196001678 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196001679 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 246196001680 active site 246196001681 catalytic triad [active] 246196001682 dimer interface [polypeptide binding]; other site 246196001683 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 246196001684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196001685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196001686 DNA binding residues [nucleotide binding] 246196001687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196001688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196001689 DNA binding residues [nucleotide binding] 246196001690 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196001691 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196001692 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196001693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001694 putative substrate translocation pore; other site 246196001695 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001696 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196001697 active site 246196001698 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196001699 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196001700 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196001701 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 246196001702 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196001703 inhibitor-cofactor binding pocket; inhibition site 246196001704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196001705 catalytic residue [active] 246196001706 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196001707 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 246196001708 tetramerization interface [polypeptide binding]; other site 246196001709 NAD(P) binding site [chemical binding]; other site 246196001710 catalytic residues [active] 246196001711 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196001712 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196001713 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246196001714 anti sigma factor interaction site; other site 246196001715 regulatory phosphorylation site [posttranslational modification]; other site 246196001716 Domain of unknown function (DUF718); Region: DUF718; pfam05336 246196001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001718 putative substrate translocation pore; other site 246196001719 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 246196001720 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 246196001721 short chain dehydrogenase; Validated; Region: PRK08324 246196001722 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 246196001723 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 246196001724 putative NAD(P) binding site [chemical binding]; other site 246196001725 active site 246196001726 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 246196001727 N- and C-terminal domain interface [polypeptide binding]; other site 246196001728 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 246196001729 active site 246196001730 putative catalytic site [active] 246196001731 metal binding site [ion binding]; metal-binding site 246196001732 ATP binding site [chemical binding]; other site 246196001733 carbohydrate binding site [chemical binding]; other site 246196001734 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196001735 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196001736 DNA binding site [nucleotide binding] 246196001737 domain linker motif; other site 246196001738 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196001739 ligand binding site [chemical binding]; other site 246196001740 dimerization interface [polypeptide binding]; other site 246196001741 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 246196001742 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 246196001743 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 246196001744 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 246196001745 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246196001746 Cysteine-rich domain; Region: CCG; pfam02754 246196001747 Cysteine-rich domain; Region: CCG; pfam02754 246196001748 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196001749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001750 DNA-binding site [nucleotide binding]; DNA binding site 246196001751 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196001752 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 246196001753 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 246196001754 nucleotide binding site [chemical binding]; other site 246196001755 acyl-CoA synthetase; Validated; Region: PRK07788 246196001756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196001757 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196001758 putative active site [active] 246196001759 putative CoA binding site [chemical binding]; other site 246196001760 putative AMP binding site [chemical binding]; other site 246196001761 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196001762 classical (c) SDRs; Region: SDR_c; cd05233 246196001763 NAD(P) binding site [chemical binding]; other site 246196001764 active site 246196001765 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001766 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196001767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196001768 active site 246196001769 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001770 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 246196001771 FAD binding site [chemical binding]; other site 246196001772 substrate binding site [chemical binding]; other site 246196001773 catalytic base [active] 246196001774 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 246196001775 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 246196001776 putative ligand binding site [chemical binding]; other site 246196001777 putative NAD binding site [chemical binding]; other site 246196001778 catalytic site [active] 246196001779 Esterase/lipase [General function prediction only]; Region: COG1647 246196001780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001782 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 246196001783 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196001784 Zn binding site [ion binding]; other site 246196001785 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196001786 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196001787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196001788 salt bridge; other site 246196001789 non-specific DNA binding site [nucleotide binding]; other site 246196001790 sequence-specific DNA binding site [nucleotide binding]; other site 246196001791 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196001792 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 246196001793 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196001794 substrate binding pocket [chemical binding]; other site 246196001795 catalytic triad [active] 246196001796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001797 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 246196001798 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196001799 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196001800 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 246196001801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196001802 Walker A motif; other site 246196001803 ATP binding site [chemical binding]; other site 246196001804 Walker B motif; other site 246196001805 arginine finger; other site 246196001806 Protein of unknown function (DUF690); Region: DUF690; pfam05108 246196001807 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 246196001808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196001809 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 246196001810 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196001811 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196001812 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 246196001813 PPE family; Region: PPE; pfam00823 246196001814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 246196001815 EspG family; Region: ESX-1_EspG; pfam14011 246196001816 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 246196001817 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 246196001818 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 246196001819 catalytic triad [active] 246196001820 putative active site [active] 246196001821 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 246196001822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196001823 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196001824 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246196001825 Amidohydrolase; Region: Amidohydro_4; pfam13147 246196001826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 246196001827 active site 246196001828 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 246196001829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196001830 S-adenosylmethionine binding site [chemical binding]; other site 246196001831 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 246196001832 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196001833 Sulfatase; Region: Sulfatase; cl17466 246196001834 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 246196001835 active site 246196001836 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 246196001837 active site 246196001838 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 246196001839 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246196001840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 246196001841 SnoaL-like domain; Region: SnoaL_3; pfam13474 246196001842 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 246196001843 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196001844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196001845 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196001846 iron-sulfur cluster [ion binding]; other site 246196001847 [2Fe-2S] cluster binding site [ion binding]; other site 246196001848 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196001849 nucleotide binding site [chemical binding]; other site 246196001850 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 246196001851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196001852 Walker A/P-loop; other site 246196001853 ATP binding site [chemical binding]; other site 246196001854 Q-loop/lid; other site 246196001855 ABC transporter signature motif; other site 246196001856 Walker B; other site 246196001857 D-loop; other site 246196001858 H-loop/switch region; other site 246196001859 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 246196001860 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 246196001861 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196001862 Walker A/P-loop; other site 246196001863 ATP binding site [chemical binding]; other site 246196001864 Q-loop/lid; other site 246196001865 ABC transporter signature motif; other site 246196001866 Walker B; other site 246196001867 D-loop; other site 246196001868 H-loop/switch region; other site 246196001869 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 246196001870 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196001871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001872 dimer interface [polypeptide binding]; other site 246196001873 conserved gate region; other site 246196001874 putative PBP binding loops; other site 246196001875 ABC-ATPase subunit interface; other site 246196001876 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196001877 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 246196001878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001879 dimer interface [polypeptide binding]; other site 246196001880 conserved gate region; other site 246196001881 putative PBP binding loops; other site 246196001882 ABC-ATPase subunit interface; other site 246196001883 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 246196001884 peptide binding site [polypeptide binding]; other site 246196001885 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 246196001886 Cupin domain; Region: Cupin_2; pfam07883 246196001887 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 246196001888 active site 246196001889 catalytic residues [active] 246196001890 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 246196001891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001892 dimer interface [polypeptide binding]; other site 246196001893 conserved gate region; other site 246196001894 putative PBP binding loops; other site 246196001895 ABC-ATPase subunit interface; other site 246196001896 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 246196001897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001898 dimer interface [polypeptide binding]; other site 246196001899 conserved gate region; other site 246196001900 putative PBP binding loops; other site 246196001901 ABC-ATPase subunit interface; other site 246196001902 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 246196001903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196001904 Walker A/P-loop; other site 246196001905 ATP binding site [chemical binding]; other site 246196001906 Q-loop/lid; other site 246196001907 ABC transporter signature motif; other site 246196001908 Walker B; other site 246196001909 D-loop; other site 246196001910 H-loop/switch region; other site 246196001911 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 246196001912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001913 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196001914 DNA-binding site [nucleotide binding]; DNA binding site 246196001915 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 246196001916 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196001917 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196001918 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196001919 classical (c) SDRs; Region: SDR_c; cd05233 246196001920 NAD(P) binding site [chemical binding]; other site 246196001921 active site 246196001922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001924 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196001925 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196001926 [2Fe-2S] cluster binding site [ion binding]; other site 246196001927 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 246196001928 putative alpha subunit interface [polypeptide binding]; other site 246196001929 putative active site [active] 246196001930 putative substrate binding site [chemical binding]; other site 246196001931 Fe binding site [ion binding]; other site 246196001932 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196001933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001934 dimer interface [polypeptide binding]; other site 246196001935 conserved gate region; other site 246196001936 putative PBP binding loops; other site 246196001937 ABC-ATPase subunit interface; other site 246196001938 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196001939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001940 dimer interface [polypeptide binding]; other site 246196001941 conserved gate region; other site 246196001942 putative PBP binding loops; other site 246196001943 ABC-ATPase subunit interface; other site 246196001944 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 246196001945 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246196001946 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 246196001947 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196001948 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196001949 catalytic residue [active] 246196001950 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196001951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196001952 Walker A/P-loop; other site 246196001953 ATP binding site [chemical binding]; other site 246196001954 Q-loop/lid; other site 246196001955 ABC transporter signature motif; other site 246196001956 Walker B; other site 246196001957 D-loop; other site 246196001958 H-loop/switch region; other site 246196001959 TOBE domain; Region: TOBE_2; pfam08402 246196001960 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 246196001961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001962 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246196001963 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246196001964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196001965 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 246196001966 CoA binding domain; Region: CoA_binding_2; pfam13380 246196001967 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 246196001968 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 246196001969 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196001970 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001971 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196001972 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196001973 active site 246196001974 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 246196001975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196001976 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 246196001977 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196001978 NAD binding site [chemical binding]; other site 246196001979 catalytic Zn binding site [ion binding]; other site 246196001980 structural Zn binding site [ion binding]; other site 246196001981 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 246196001982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196001983 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196001984 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196001985 Cytochrome P450; Region: p450; cl12078 246196001986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001987 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 246196001988 trimer interface [polypeptide binding]; other site 246196001989 active site 246196001990 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 246196001991 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196001992 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246196001993 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246196001994 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196001995 Cytochrome P450; Region: p450; cl12078 246196001996 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196001997 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196001998 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 246196001999 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196002000 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196002001 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196002002 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196002003 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196002004 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 246196002005 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196002006 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196002007 catalytic loop [active] 246196002008 iron binding site [ion binding]; other site 246196002009 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196002010 YibE/F-like protein; Region: YibE_F; pfam07907 246196002011 aminotransferase AlaT; Validated; Region: PRK09265 246196002012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196002013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002014 homodimer interface [polypeptide binding]; other site 246196002015 catalytic residue [active] 246196002016 4Fe-4S binding domain; Region: Fer4; cl02805 246196002017 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246196002018 4Fe-4S binding domain; Region: Fer4; pfam00037 246196002019 Cysteine-rich domain; Region: CCG; pfam02754 246196002020 Cysteine-rich domain; Region: CCG; pfam02754 246196002021 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246196002022 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196002023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196002024 DNA binding residues [nucleotide binding] 246196002025 dimerization interface [polypeptide binding]; other site 246196002026 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196002027 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246196002028 Dynamin family; Region: Dynamin_N; pfam00350 246196002029 G1 box; other site 246196002030 GTP/Mg2+ binding site [chemical binding]; other site 246196002031 G2 box; other site 246196002032 Switch I region; other site 246196002033 G3 box; other site 246196002034 Switch II region; other site 246196002035 G4 box; other site 246196002036 G5 box; other site 246196002037 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 246196002038 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 246196002039 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 246196002040 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246196002041 G1 box; other site 246196002042 GTP/Mg2+ binding site [chemical binding]; other site 246196002043 G2 box; other site 246196002044 Switch I region; other site 246196002045 G3 box; other site 246196002046 Switch II region; other site 246196002047 G4 box; other site 246196002048 G5 box; other site 246196002049 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196002050 nucleotide binding site [chemical binding]; other site 246196002051 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196002052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196002053 TIGR03085 family protein; Region: TIGR03085 246196002054 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196002055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002056 putative substrate translocation pore; other site 246196002057 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 246196002058 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 246196002059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196002060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196002061 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 246196002062 putative dimerization interface [polypeptide binding]; other site 246196002063 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 246196002064 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 246196002065 nucleotide binding site [chemical binding]; other site 246196002066 NEF interaction site [polypeptide binding]; other site 246196002067 SBD interface [polypeptide binding]; other site 246196002068 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 246196002069 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 246196002070 dimer interface [polypeptide binding]; other site 246196002071 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 246196002072 chaperone protein DnaJ; Provisional; Region: PRK14279 246196002073 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246196002074 HSP70 interaction site [polypeptide binding]; other site 246196002075 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 246196002076 Zn binding sites [ion binding]; other site 246196002077 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 246196002078 dimer interface [polypeptide binding]; other site 246196002079 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 246196002080 DNA binding residues [nucleotide binding] 246196002081 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196002082 putative dimer interface [polypeptide binding]; other site 246196002083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002085 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196002086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196002087 active site 246196002088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002089 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246196002090 NAD(P) binding site [chemical binding]; other site 246196002091 active site 246196002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002093 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196002094 putative substrate translocation pore; other site 246196002095 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 246196002096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196002097 acyl-activating enzyme (AAE) consensus motif; other site 246196002098 AMP binding site [chemical binding]; other site 246196002099 active site 246196002100 CoA binding site [chemical binding]; other site 246196002101 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 246196002102 active site 246196002103 catalytic residues [active] 246196002104 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 246196002105 heme-binding site [chemical binding]; other site 246196002106 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 246196002107 FMN reductase; Validated; Region: fre; PRK08051 246196002108 FAD binding pocket [chemical binding]; other site 246196002109 FAD binding motif [chemical binding]; other site 246196002110 phosphate binding motif [ion binding]; other site 246196002111 beta-alpha-beta structure motif; other site 246196002112 NAD binding pocket [chemical binding]; other site 246196002113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196002116 Transposase; Region: HTH_Tnp_1; cl17663 246196002117 putative transposase OrfB; Reviewed; Region: PHA02517 246196002118 HTH-like domain; Region: HTH_21; pfam13276 246196002119 Integrase core domain; Region: rve; pfam00665 246196002120 Integrase core domain; Region: rve_3; pfam13683 246196002121 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196002122 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196002123 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196002124 homodimer interface [polypeptide binding]; other site 246196002125 active site 246196002126 TDP-binding site; other site 246196002127 glycosyltransferase, MGT family; Region: MGT; TIGR01426 246196002128 acceptor substrate-binding pocket; other site 246196002129 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 246196002130 putative dimer interface [polypeptide binding]; other site 246196002131 putative active site [active] 246196002132 putative phosphate binding site [ion binding]; other site 246196002133 putative metal binding residues [ion binding]; other site 246196002134 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 246196002135 Clp amino terminal domain; Region: Clp_N; pfam02861 246196002136 Clp amino terminal domain; Region: Clp_N; pfam02861 246196002137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002138 Walker A motif; other site 246196002139 ATP binding site [chemical binding]; other site 246196002140 Walker B motif; other site 246196002141 arginine finger; other site 246196002142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002143 Walker A motif; other site 246196002144 ATP binding site [chemical binding]; other site 246196002145 Walker B motif; other site 246196002146 arginine finger; other site 246196002147 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246196002148 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196002149 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196002150 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196002151 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196002152 [2Fe-2S] cluster binding site [ion binding]; other site 246196002153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 246196002154 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 246196002155 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196002156 classical (c) SDRs; Region: SDR_c; cd05233 246196002157 NAD(P) binding site [chemical binding]; other site 246196002158 active site 246196002159 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 246196002160 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 246196002161 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196002162 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 246196002163 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196002164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196002165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196002166 LysR substrate binding domain; Region: LysR_substrate; pfam03466 246196002167 dimerization interface [polypeptide binding]; other site 246196002168 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246196002169 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246196002170 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 246196002171 XdhC Rossmann domain; Region: XdhC_C; pfam13478 246196002172 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196002173 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 246196002174 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196002175 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196002176 catalytic loop [active] 246196002177 iron binding site [ion binding]; other site 246196002178 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196002179 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 246196002180 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 246196002181 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196002182 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 246196002183 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246196002184 XdhC Rossmann domain; Region: XdhC_C; pfam13478 246196002185 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196002186 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 246196002187 putative hydrophobic ligand binding site [chemical binding]; other site 246196002188 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 246196002189 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246196002190 metal ion-dependent adhesion site (MIDAS); other site 246196002191 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 246196002192 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 246196002193 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 246196002194 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 246196002195 active site 246196002196 intersubunit interface [polypeptide binding]; other site 246196002197 zinc binding site [ion binding]; other site 246196002198 Na+ binding site [ion binding]; other site 246196002199 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 246196002200 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 246196002201 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 246196002202 Peptidase family M50; Region: Peptidase_M50; pfam02163 246196002203 active site 246196002204 putative substrate binding region [chemical binding]; other site 246196002205 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 246196002206 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 246196002207 GDP-binding site [chemical binding]; other site 246196002208 ACT binding site; other site 246196002209 IMP binding site; other site 246196002210 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196002211 CoenzymeA binding site [chemical binding]; other site 246196002212 subunit interaction site [polypeptide binding]; other site 246196002213 PHB binding site; other site 246196002214 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196002215 Cytochrome P450; Region: p450; cl12078 246196002216 MMPL family; Region: MMPL; pfam03176 246196002217 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 246196002218 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 246196002219 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 246196002220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002221 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196002222 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 246196002223 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 246196002224 active site residue [active] 246196002225 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 246196002226 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246196002227 homodimer interface [polypeptide binding]; other site 246196002228 substrate-cofactor binding pocket; other site 246196002229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002230 catalytic residue [active] 246196002231 short chain dehydrogenase; Provisional; Region: PRK07825 246196002232 classical (c) SDRs; Region: SDR_c; cd05233 246196002233 NAD(P) binding site [chemical binding]; other site 246196002234 active site 246196002235 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 246196002236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196002237 Coenzyme A binding pocket [chemical binding]; other site 246196002238 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 246196002239 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246196002240 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196002241 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 246196002242 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196002243 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196002244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196002245 DNA-binding site [nucleotide binding]; DNA binding site 246196002246 UTRA domain; Region: UTRA; pfam07702 246196002247 short chain dehydrogenase; Provisional; Region: PRK12829 246196002248 classical (c) SDRs; Region: SDR_c; cd05233 246196002249 NAD(P) binding site [chemical binding]; other site 246196002250 active site 246196002251 Phosphotransferase enzyme family; Region: APH; pfam01636 246196002252 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 246196002253 amino acid transporter; Region: 2A0306; TIGR00909 246196002254 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 246196002255 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196002256 inhibitor-cofactor binding pocket; inhibition site 246196002257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002258 catalytic residue [active] 246196002259 phosphate acetyltransferase; Reviewed; Region: PRK05632 246196002260 DRTGG domain; Region: DRTGG; pfam07085 246196002261 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 246196002262 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 246196002263 propionate/acetate kinase; Provisional; Region: PRK12379 246196002264 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196002265 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196002266 active site 246196002267 ATP binding site [chemical binding]; other site 246196002268 substrate binding site [chemical binding]; other site 246196002269 activation loop (A-loop); other site 246196002270 Protein of unknown function (DUF406); Region: DUF406; cl11449 246196002271 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196002272 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196002273 substrate binding pocket [chemical binding]; other site 246196002274 membrane-bound complex binding site; other site 246196002275 hinge residues; other site 246196002276 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 246196002277 nudix motif; other site 246196002278 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 246196002279 thiamine phosphate binding site [chemical binding]; other site 246196002280 active site 246196002281 pyrophosphate binding site [ion binding]; other site 246196002282 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 246196002283 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 246196002284 thiS-thiF/thiG interaction site; other site 246196002285 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 246196002286 ThiS interaction site; other site 246196002287 putative active site [active] 246196002288 tetramer interface [polypeptide binding]; other site 246196002289 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 246196002290 active site 246196002291 catalytic triad [active] 246196002292 oxyanion hole [active] 246196002293 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196002294 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 246196002295 Walker A/P-loop; other site 246196002296 ATP binding site [chemical binding]; other site 246196002297 Q-loop/lid; other site 246196002298 ABC transporter signature motif; other site 246196002299 Walker B; other site 246196002300 D-loop; other site 246196002301 H-loop/switch region; other site 246196002302 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 246196002303 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196002304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196002305 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196002306 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 246196002307 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 246196002308 PA/protease or protease-like domain interface [polypeptide binding]; other site 246196002309 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 246196002310 Peptidase family M28; Region: Peptidase_M28; pfam04389 246196002311 active site 246196002312 metal binding site [ion binding]; metal-binding site 246196002313 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 246196002314 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 246196002315 PA/protease or protease-like domain interface [polypeptide binding]; other site 246196002316 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 246196002317 Peptidase family M28; Region: Peptidase_M28; pfam04389 246196002318 active site 246196002319 metal binding site [ion binding]; metal-binding site 246196002320 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 246196002321 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 246196002322 malonyl-CoA binding site [chemical binding]; other site 246196002323 dimer interface [polypeptide binding]; other site 246196002324 active site 246196002325 product binding site; other site 246196002326 Phospholipid methyltransferase; Region: PEMT; cl17370 246196002327 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 246196002328 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 246196002329 amino acid transporter; Region: 2A0306; TIGR00909 246196002330 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196002331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002335 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196002336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196002337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196002338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196002339 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 246196002340 putative substrate binding pocket [chemical binding]; other site 246196002341 dimerization interface [polypeptide binding]; other site 246196002342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002343 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196002344 putative substrate translocation pore; other site 246196002345 allantoate amidohydrolase; Reviewed; Region: PRK09290 246196002346 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 246196002347 active site 246196002348 metal binding site [ion binding]; metal-binding site 246196002349 dimer interface [polypeptide binding]; other site 246196002350 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196002351 Amidase; Region: Amidase; cl11426 246196002352 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 246196002353 Cytochrome P450; Region: p450; cl12078 246196002354 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196002355 Septum formation; Region: Septum_form; pfam13845 246196002356 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 246196002357 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 246196002358 dimer interface [polypeptide binding]; other site 246196002359 substrate binding site [chemical binding]; other site 246196002360 ATP binding site [chemical binding]; other site 246196002361 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 246196002362 ThiC-associated domain; Region: ThiC-associated; pfam13667 246196002363 ThiC family; Region: ThiC; pfam01964 246196002364 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 246196002365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002366 putative substrate translocation pore; other site 246196002367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 246196002368 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 246196002369 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 246196002370 putative catalytic site [active] 246196002371 putative phosphate binding site [ion binding]; other site 246196002372 active site 246196002373 metal binding site A [ion binding]; metal-binding site 246196002374 DNA binding site [nucleotide binding] 246196002375 putative AP binding site [nucleotide binding]; other site 246196002376 putative metal binding site B [ion binding]; other site 246196002377 short chain dehydrogenase; Provisional; Region: PRK07577 246196002378 classical (c) SDRs; Region: SDR_c; cd05233 246196002379 NAD(P) binding site [chemical binding]; other site 246196002380 active site 246196002381 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 246196002382 active site 246196002383 catalytic residues [active] 246196002384 metal binding site [ion binding]; metal-binding site 246196002385 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 246196002386 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 246196002387 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 246196002388 E-class dimer interface [polypeptide binding]; other site 246196002389 P-class dimer interface [polypeptide binding]; other site 246196002390 active site 246196002391 Cu2+ binding site [ion binding]; other site 246196002392 Zn2+ binding site [ion binding]; other site 246196002393 carboxylate-amine ligase; Provisional; Region: PRK13517 246196002394 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 246196002395 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196002396 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 246196002397 putative DNA binding site [nucleotide binding]; other site 246196002398 putative Zn2+ binding site [ion binding]; other site 246196002399 AsnC family; Region: AsnC_trans_reg; pfam01037 246196002400 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196002401 AsnC family; Region: AsnC_trans_reg; pfam01037 246196002402 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 246196002403 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 246196002404 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 246196002405 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 246196002406 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 246196002407 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196002408 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 246196002409 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 246196002410 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 246196002411 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196002412 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 246196002413 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 246196002414 hypothetical protein; Provisional; Region: PRK08244 246196002415 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 246196002416 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 246196002417 transmembrane helices; other site 246196002418 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 246196002419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196002420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 246196002421 Histidine kinase; Region: HisKA_3; pfam07730 246196002422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196002423 ATP binding site [chemical binding]; other site 246196002424 Mg2+ binding site [ion binding]; other site 246196002425 G-X-G motif; other site 246196002426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196002427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002428 active site 246196002429 phosphorylation site [posttranslational modification] 246196002430 intermolecular recognition site; other site 246196002431 dimerization interface [polypeptide binding]; other site 246196002432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196002433 DNA binding residues [nucleotide binding] 246196002434 dimerization interface [polypeptide binding]; other site 246196002435 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196002436 2TM domain; Region: 2TM; pfam13239 246196002437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002438 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 246196002439 putative hydrophobic ligand binding site [chemical binding]; other site 246196002440 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 246196002441 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 246196002442 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 246196002443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002444 Walker A motif; other site 246196002445 ATP binding site [chemical binding]; other site 246196002446 Walker B motif; other site 246196002447 arginine finger; other site 246196002448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002449 Walker A motif; other site 246196002450 ATP binding site [chemical binding]; other site 246196002451 Walker B motif; other site 246196002452 arginine finger; other site 246196002453 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 246196002454 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 246196002455 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 246196002456 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 246196002457 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246196002458 dimer interface [polypeptide binding]; other site 246196002459 putative functional site; other site 246196002460 putative MPT binding site; other site 246196002461 short chain dehydrogenase; Provisional; Region: PRK06197 246196002462 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 246196002463 putative NAD(P) binding site [chemical binding]; other site 246196002464 active site 246196002465 Uncharacterized conserved protein [Function unknown]; Region: COG3402 246196002466 Predicted membrane protein [Function unknown]; Region: COG3428 246196002467 Bacterial PH domain; Region: DUF304; pfam03703 246196002468 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 246196002469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196002470 active site 246196002471 motif I; other site 246196002472 motif II; other site 246196002473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196002474 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 246196002475 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196002476 ATP binding site [chemical binding]; other site 246196002477 putative Mg++ binding site [ion binding]; other site 246196002478 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196002479 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196002480 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196002481 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196002482 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 246196002483 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196002484 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196002485 catalytic loop [active] 246196002486 iron binding site [ion binding]; other site 246196002487 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196002488 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196002489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196002490 DNA-binding site [nucleotide binding]; DNA binding site 246196002491 FCD domain; Region: FCD; pfam07729 246196002492 putative sialic acid transporter; Provisional; Region: PRK03893 246196002493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002495 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 246196002496 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 246196002497 inhibitor site; inhibition site 246196002498 active site 246196002499 dimer interface [polypeptide binding]; other site 246196002500 catalytic residue [active] 246196002501 short chain dehydrogenase; Provisional; Region: PRK06197 246196002502 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 246196002503 putative NAD(P) binding site [chemical binding]; other site 246196002504 active site 246196002505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002507 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 246196002508 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246196002509 ring oligomerisation interface [polypeptide binding]; other site 246196002510 ATP/Mg binding site [chemical binding]; other site 246196002511 stacking interactions; other site 246196002512 hinge regions; other site 246196002513 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196002514 putative active site [active] 246196002515 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196002516 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196002517 active site 246196002518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196002519 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 246196002520 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196002521 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196002522 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196002523 active site 246196002524 ATP binding site [chemical binding]; other site 246196002525 substrate binding site [chemical binding]; other site 246196002526 activation loop (A-loop); other site 246196002527 Protein of unknown function (DUF664); Region: DUF664; pfam04978 246196002528 DinB superfamily; Region: DinB_2; pfam12867 246196002529 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 246196002530 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 246196002531 NAD(P) binding site [chemical binding]; other site 246196002532 catalytic residues [active] 246196002533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196002534 Zn2+ binding site [ion binding]; other site 246196002535 Mg2+ binding site [ion binding]; other site 246196002536 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 246196002537 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 246196002538 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196002539 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 246196002540 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196002541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196002542 DNA-binding site [nucleotide binding]; DNA binding site 246196002543 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196002544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002545 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196002546 putative substrate translocation pore; other site 246196002547 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 246196002548 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 246196002549 active site 246196002550 intersubunit interface [polypeptide binding]; other site 246196002551 zinc binding site [ion binding]; other site 246196002552 Na+ binding site [ion binding]; other site 246196002553 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 246196002554 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196002555 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 246196002556 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196002557 NAD(P) binding site [chemical binding]; other site 246196002558 catalytic residues [active] 246196002559 Protein of unknown function (DUF779); Region: DUF779; cl01432 246196002560 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 246196002561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002562 S-adenosylmethionine binding site [chemical binding]; other site 246196002563 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 246196002564 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 246196002565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196002566 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246196002567 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196002568 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196002569 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196002570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196002571 non-specific DNA binding site [nucleotide binding]; other site 246196002572 salt bridge; other site 246196002573 sequence-specific DNA binding site [nucleotide binding]; other site 246196002574 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 246196002575 Domain of unknown function (DUF955); Region: DUF955; pfam06114 246196002576 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 246196002577 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 246196002578 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246196002579 active site 246196002580 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196002581 active site 2 [active] 246196002582 isocitrate lyase; Provisional; Region: PRK15063 246196002583 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196002584 tetramer interface [polypeptide binding]; other site 246196002585 active site 246196002586 Mg2+/Mn2+ binding site [ion binding]; other site 246196002587 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 246196002588 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196002589 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196002590 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 246196002591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002592 S-adenosylmethionine binding site [chemical binding]; other site 246196002593 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 246196002594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002596 Predicted membrane protein [Function unknown]; Region: COG2733 246196002597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196002598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196002599 non-specific DNA binding site [nucleotide binding]; other site 246196002600 salt bridge; other site 246196002601 sequence-specific DNA binding site [nucleotide binding]; other site 246196002602 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 246196002603 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 246196002604 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 246196002605 intersubunit interface [polypeptide binding]; other site 246196002606 active site 246196002607 catalytic residue [active] 246196002608 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 246196002609 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196002610 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 246196002611 putative active site [active] 246196002612 catalytic triad [active] 246196002613 putative dimer interface [polypeptide binding]; other site 246196002614 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196002615 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 246196002616 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 246196002617 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 246196002618 FAD binding domain; Region: FAD_binding_4; pfam01565 246196002619 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 246196002620 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 246196002621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196002622 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 246196002623 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196002624 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196002625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002626 NAD(P) binding site [chemical binding]; other site 246196002627 active site 246196002628 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196002629 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196002630 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 246196002631 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 246196002632 putative ADP-binding pocket [chemical binding]; other site 246196002633 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 246196002634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196002635 catalytic core [active] 246196002636 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196002637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196002638 dimer interface [polypeptide binding]; other site 246196002639 phosphorylation site [posttranslational modification] 246196002640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196002641 ATP binding site [chemical binding]; other site 246196002642 Mg2+ binding site [ion binding]; other site 246196002643 G-X-G motif; other site 246196002644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196002645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002646 active site 246196002647 phosphorylation site [posttranslational modification] 246196002648 intermolecular recognition site; other site 246196002649 dimerization interface [polypeptide binding]; other site 246196002650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196002651 DNA binding site [nucleotide binding] 246196002652 exopolyphosphatase; Region: exo_poly_only; TIGR03706 246196002653 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 246196002654 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196002655 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 246196002656 DNA interaction; other site 246196002657 Metal-binding active site; metal-binding site 246196002658 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196002659 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196002660 active site 2 [active] 246196002661 active site 1 [active] 246196002662 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 246196002663 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 246196002664 DNA binding domain, excisionase family; Region: excise; TIGR01764 246196002665 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196002666 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 246196002667 putative NAD(P) binding site [chemical binding]; other site 246196002668 active site 246196002669 putative substrate binding site [chemical binding]; other site 246196002670 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246196002671 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 246196002672 putative acyl-acceptor binding pocket; other site 246196002673 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196002674 active site 246196002675 catalytic site [active] 246196002676 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 246196002677 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246196002678 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 246196002679 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 246196002680 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 246196002681 tRNA; other site 246196002682 putative tRNA binding site [nucleotide binding]; other site 246196002683 putative NADP binding site [chemical binding]; other site 246196002684 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 246196002685 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 246196002686 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 246196002687 domain interfaces; other site 246196002688 active site 246196002689 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 246196002690 active site 246196002691 homodimer interface [polypeptide binding]; other site 246196002692 SAM binding site [chemical binding]; other site 246196002693 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 246196002694 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 246196002695 active site 246196002696 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 246196002697 dimer interface [polypeptide binding]; other site 246196002698 active site 246196002699 Schiff base residues; other site 246196002700 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 246196002701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002703 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 246196002704 MspA; Region: MspA; pfam09203 246196002705 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196002706 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196002707 Cytochrome P450; Region: p450; cl12078 246196002708 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196002709 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 246196002710 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196002711 inhibitor-cofactor binding pocket; inhibition site 246196002712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002713 catalytic residue [active] 246196002714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196002715 catalytic core [active] 246196002716 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246196002717 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246196002718 catalytic residues [active] 246196002719 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 246196002720 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 246196002721 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 246196002722 ResB-like family; Region: ResB; pfam05140 246196002723 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 246196002724 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196002725 AAA domain; Region: AAA_31; pfam13614 246196002726 P-loop; other site 246196002727 Magnesium ion binding site [ion binding]; other site 246196002728 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 246196002729 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246196002730 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196002731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196002732 catalytic residue [active] 246196002733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196002734 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246196002735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196002736 Histidine kinase; Region: HisKA_3; pfam07730 246196002737 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 246196002738 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 246196002739 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 246196002740 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196002741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002742 active site 246196002743 phosphorylation site [posttranslational modification] 246196002744 intermolecular recognition site; other site 246196002745 dimerization interface [polypeptide binding]; other site 246196002746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196002747 DNA binding residues [nucleotide binding] 246196002748 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 246196002749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002750 putative substrate translocation pore; other site 246196002751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002753 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 246196002754 UbiA prenyltransferase family; Region: UbiA; pfam01040 246196002755 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 246196002756 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196002757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002758 NAD(P) binding site [chemical binding]; other site 246196002759 active site 246196002760 Nitronate monooxygenase; Region: NMO; pfam03060 246196002761 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196002762 FMN binding site [chemical binding]; other site 246196002763 substrate binding site [chemical binding]; other site 246196002764 putative catalytic residue [active] 246196002765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196002766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196002767 dimer interface [polypeptide binding]; other site 246196002768 phosphorylation site [posttranslational modification] 246196002769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196002770 Mg2+ binding site [ion binding]; other site 246196002771 G-X-G motif; other site 246196002772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196002773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002774 active site 246196002775 phosphorylation site [posttranslational modification] 246196002776 intermolecular recognition site; other site 246196002777 dimerization interface [polypeptide binding]; other site 246196002778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196002779 DNA binding site [nucleotide binding] 246196002780 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246196002781 Ligand binding site; other site 246196002782 Putative Catalytic site; other site 246196002783 DXD motif; other site 246196002784 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 246196002785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002786 S-adenosylmethionine binding site [chemical binding]; other site 246196002787 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 246196002788 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 246196002789 Moco binding site; other site 246196002790 metal coordination site [ion binding]; other site 246196002791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 246196002792 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196002793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196002794 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196002795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002796 S-adenosylmethionine binding site [chemical binding]; other site 246196002797 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196002798 Phosphotransferase enzyme family; Region: APH; pfam01636 246196002799 putative active site [active] 246196002800 putative substrate binding site [chemical binding]; other site 246196002801 ATP binding site [chemical binding]; other site 246196002802 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196002803 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 246196002804 Cytochrome P450; Region: p450; cl12078 246196002805 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196002806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002808 short chain dehydrogenase; Provisional; Region: PRK07832 246196002809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002810 NAD(P) binding site [chemical binding]; other site 246196002811 active site 246196002812 alkaline phosphatase; Provisional; Region: PRK10518 246196002813 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 246196002814 dimer interface [polypeptide binding]; other site 246196002815 active site 246196002816 Predicted ATPase [General function prediction only]; Region: COG4637 246196002817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196002818 Walker A/P-loop; other site 246196002819 ATP binding site [chemical binding]; other site 246196002820 DNA polymerase IV; Validated; Region: PRK03352 246196002821 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246196002822 active site 246196002823 DNA binding site [nucleotide binding] 246196002824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002826 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246196002827 Predicted flavoprotein [General function prediction only]; Region: COG0431 246196002828 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 246196002829 catalytic residues [active] 246196002830 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 246196002831 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 246196002832 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 246196002833 Class I ribonucleotide reductase; Region: RNR_I; cd01679 246196002834 active site 246196002835 dimer interface [polypeptide binding]; other site 246196002836 catalytic residues [active] 246196002837 effector binding site; other site 246196002838 R2 peptide binding site; other site 246196002839 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196002840 dimerization interface [polypeptide binding]; other site 246196002841 substrate binding pocket [chemical binding]; other site 246196002842 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196002843 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 246196002844 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196002845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002846 putative substrate translocation pore; other site 246196002847 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 246196002848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196002849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002851 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196002852 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196002853 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246196002854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002856 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196002857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196002858 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 246196002859 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 246196002860 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 246196002861 dimer interface [polypeptide binding]; other site 246196002862 putative radical transfer pathway; other site 246196002863 diiron center [ion binding]; other site 246196002864 tyrosyl radical; other site 246196002865 Predicted esterase [General function prediction only]; Region: COG0627 246196002866 S-formylglutathione hydrolase; Region: PLN02442 246196002867 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246196002868 potential frameshift: common BLAST hit: gi|126433506|ref|YP_001069197.1| putative monooxygenase 246196002869 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196002870 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196002871 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196002872 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196002873 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 246196002874 putative NAD(P) binding site [chemical binding]; other site 246196002875 putative substrate binding site [chemical binding]; other site 246196002876 catalytic Zn binding site [ion binding]; other site 246196002877 structural Zn binding site [ion binding]; other site 246196002878 dimer interface [polypeptide binding]; other site 246196002879 YCII-related domain; Region: YCII; cl00999 246196002880 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196002881 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246196002882 intersubunit interface [polypeptide binding]; other site 246196002883 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 246196002884 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 246196002885 D-pathway; other site 246196002886 Putative ubiquinol binding site [chemical binding]; other site 246196002887 Low-spin heme (heme b) binding site [chemical binding]; other site 246196002888 Putative water exit pathway; other site 246196002889 Binuclear center (heme o3/CuB) [ion binding]; other site 246196002890 K-pathway; other site 246196002891 Putative proton exit pathway; other site 246196002892 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 246196002893 cytochrome o ubiquinol oxidase subunit I; Provisional; Region: PRK15017 246196002894 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 246196002895 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 246196002896 phosphoserine phosphatase SerB; Region: serB; TIGR00338 246196002897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196002898 motif II; other site 246196002899 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196002900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196002901 DNA-binding site [nucleotide binding]; DNA binding site 246196002902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196002903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002904 homodimer interface [polypeptide binding]; other site 246196002905 catalytic residue [active] 246196002906 Predicted membrane protein [Function unknown]; Region: COG2364 246196002907 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 246196002908 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 246196002909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196002910 Walker A/P-loop; other site 246196002911 ATP binding site [chemical binding]; other site 246196002912 Q-loop/lid; other site 246196002913 ABC transporter signature motif; other site 246196002914 Walker B; other site 246196002915 D-loop; other site 246196002916 H-loop/switch region; other site 246196002917 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196002918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196002919 substrate binding site [chemical binding]; other site 246196002920 oxyanion hole (OAH) forming residues; other site 246196002921 trimer interface [polypeptide binding]; other site 246196002922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002923 S-adenosylmethionine binding site [chemical binding]; other site 246196002924 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 246196002925 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 246196002926 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 246196002927 FOG: WD40-like repeat [Function unknown]; Region: COG1520 246196002928 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196002929 active site 246196002930 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 246196002931 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 246196002932 trimer interface [polypeptide binding]; other site 246196002933 active site 246196002934 substrate binding site [chemical binding]; other site 246196002935 CoA binding site [chemical binding]; other site 246196002936 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 246196002937 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 246196002938 homotetramer interface [polypeptide binding]; other site 246196002939 FMN binding site [chemical binding]; other site 246196002940 homodimer contacts [polypeptide binding]; other site 246196002941 putative active site [active] 246196002942 putative substrate binding site [chemical binding]; other site 246196002943 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196002944 Lsr2; Region: Lsr2; pfam11774 246196002945 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 246196002946 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 246196002947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196002948 active site 246196002949 CoA binding site [chemical binding]; other site 246196002950 AMP binding site [chemical binding]; other site 246196002951 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 246196002952 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 246196002953 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 246196002954 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196002955 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196002956 active site 246196002957 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196002958 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196002959 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196002960 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196002961 classical (c) SDRs; Region: SDR_c; cd05233 246196002962 NAD(P) binding site [chemical binding]; other site 246196002963 active site 246196002964 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196002965 classical (c) SDRs; Region: SDR_c; cd05233 246196002966 NAD(P) binding site [chemical binding]; other site 246196002967 active site 246196002968 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 246196002969 agmatinase; Region: agmatinase; TIGR01230 246196002970 oligomer interface [polypeptide binding]; other site 246196002971 putative active site [active] 246196002972 Mn binding site [ion binding]; other site 246196002973 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 246196002974 tetramer interface [polypeptide binding]; other site 246196002975 active site 246196002976 short chain dehydrogenase; Provisional; Region: PRK05866 246196002977 classical (c) SDRs; Region: SDR_c; cd05233 246196002978 NAD(P) binding site [chemical binding]; other site 246196002979 active site 246196002980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196002981 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 246196002982 substrate binding site [chemical binding]; other site 246196002983 oxyanion hole (OAH) forming residues; other site 246196002984 trimer interface [polypeptide binding]; other site 246196002985 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196002986 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 246196002987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196002988 motif II; other site 246196002989 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 246196002990 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196002991 iron-sulfur cluster [ion binding]; other site 246196002992 [2Fe-2S] cluster binding site [ion binding]; other site 246196002993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196002994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196002995 DNA binding residues [nucleotide binding] 246196002996 dimerization interface [polypeptide binding]; other site 246196002997 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 246196002998 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196002999 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196003000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196003001 dimer interface [polypeptide binding]; other site 246196003002 conserved gate region; other site 246196003003 ABC-ATPase subunit interface; other site 246196003004 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 246196003005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196003006 dimer interface [polypeptide binding]; other site 246196003007 conserved gate region; other site 246196003008 putative PBP binding loops; other site 246196003009 ABC-ATPase subunit interface; other site 246196003010 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 246196003011 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196003012 Walker A/P-loop; other site 246196003013 ATP binding site [chemical binding]; other site 246196003014 Q-loop/lid; other site 246196003015 ABC transporter signature motif; other site 246196003016 Walker B; other site 246196003017 D-loop; other site 246196003018 H-loop/switch region; other site 246196003019 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 246196003020 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 246196003021 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196003022 Walker A/P-loop; other site 246196003023 ATP binding site [chemical binding]; other site 246196003024 Q-loop/lid; other site 246196003025 ABC transporter signature motif; other site 246196003026 Walker B; other site 246196003027 D-loop; other site 246196003028 H-loop/switch region; other site 246196003029 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196003030 Amidase; Region: Amidase; pfam01425 246196003031 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196003032 Amidase; Region: Amidase; pfam01425 246196003033 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 246196003034 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 246196003035 dimer interface [polypeptide binding]; other site 246196003036 catalytic residues [active] 246196003037 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 246196003038 UreF; Region: UreF; pfam01730 246196003039 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 246196003040 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 246196003041 alpha-gamma subunit interface [polypeptide binding]; other site 246196003042 beta-gamma subunit interface [polypeptide binding]; other site 246196003043 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 246196003044 gamma-beta subunit interface [polypeptide binding]; other site 246196003045 alpha-beta subunit interface [polypeptide binding]; other site 246196003046 urease subunit alpha; Reviewed; Region: ureC; PRK13308 246196003047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196003048 active site 246196003049 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246196003050 G1 box; other site 246196003051 GTP/Mg2+ binding site [chemical binding]; other site 246196003052 G2 box; other site 246196003053 Switch I region; other site 246196003054 G3 box; other site 246196003055 Switch II region; other site 246196003056 G4 box; other site 246196003057 G5 box; other site 246196003058 UreD urease accessory protein; Region: UreD; cl00530 246196003059 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246196003060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196003061 active site 246196003062 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196003063 acyl-CoA synthetase; Validated; Region: PRK06188 246196003064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196003065 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196003066 putative active site [active] 246196003067 putative CoA binding site [chemical binding]; other site 246196003068 putative AMP binding site [chemical binding]; other site 246196003069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 246196003070 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196003071 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 246196003072 active site 246196003073 O-succinylbenzoate synthase; Provisional; Region: PRK02901 246196003074 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 246196003075 active site 246196003076 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196003077 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 246196003078 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196003079 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246196003080 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196003081 conserved cys residue [active] 246196003082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196003083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196003084 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 246196003085 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 246196003086 conserved cys residue [active] 246196003087 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196003088 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196003089 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196003090 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 246196003091 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 246196003092 dimer interface [polypeptide binding]; other site 246196003093 tetramer interface [polypeptide binding]; other site 246196003094 PYR/PP interface [polypeptide binding]; other site 246196003095 TPP binding site [chemical binding]; other site 246196003096 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 246196003097 TPP-binding site; other site 246196003098 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 246196003099 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246196003100 Thioredoxin; Region: Thioredoxin_4; cl17273 246196003101 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196003102 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 246196003103 aconitate hydratase; Validated; Region: PRK07229 246196003104 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246196003105 substrate binding site [chemical binding]; other site 246196003106 ligand binding site [chemical binding]; other site 246196003107 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 246196003108 substrate binding site [chemical binding]; other site 246196003109 short chain dehydrogenase; Provisional; Region: PRK08263 246196003110 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196003111 NADP binding site [chemical binding]; other site 246196003112 active site 246196003113 steroid binding site; other site 246196003114 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 246196003115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003116 S-adenosylmethionine binding site [chemical binding]; other site 246196003117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196003118 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196003119 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196003120 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196003121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196003122 DNA-binding site [nucleotide binding]; DNA binding site 246196003123 FCD domain; Region: FCD; pfam07729 246196003124 Amino acid permease; Region: AA_permease; pfam00324 246196003125 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 246196003126 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 246196003127 catalytic triad [active] 246196003128 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 246196003129 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196003130 putative active site [active] 246196003131 catalytic triad [active] 246196003132 putative dimer interface [polypeptide binding]; other site 246196003133 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 246196003134 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 246196003135 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 246196003136 Ferredoxin [Energy production and conversion]; Region: COG1146 246196003137 4Fe-4S binding domain; Region: Fer4; pfam00037 246196003138 Predicted transcriptional regulator [Transcription]; Region: COG2345 246196003139 Helix-turn-helix domain; Region: HTH_20; pfam12840 246196003140 putative Zn2+ binding site [ion binding]; other site 246196003141 putative DNA binding site [nucleotide binding]; other site 246196003142 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196003143 TspO/MBR family; Region: TspO_MBR; cl01379 246196003144 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246196003145 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196003146 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 246196003147 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246196003148 substrate binding pocket [chemical binding]; other site 246196003149 chain length determination region; other site 246196003150 substrate-Mg2+ binding site; other site 246196003151 catalytic residues [active] 246196003152 aspartate-rich region 1; other site 246196003153 active site lid residues [active] 246196003154 aspartate-rich region 2; other site 246196003155 heat shock protein HtpX; Provisional; Region: PRK03072 246196003156 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196003157 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 246196003158 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196003159 NAD binding site [chemical binding]; other site 246196003160 catalytic Zn binding site [ion binding]; other site 246196003161 substrate binding site [chemical binding]; other site 246196003162 structural Zn binding site [ion binding]; other site 246196003163 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196003164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196003165 non-specific DNA binding site [nucleotide binding]; other site 246196003166 salt bridge; other site 246196003167 sequence-specific DNA binding site [nucleotide binding]; other site 246196003168 Cupin domain; Region: Cupin_2; pfam07883 246196003169 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 246196003170 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 246196003171 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 246196003172 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196003173 Permease; Region: Permease; pfam02405 246196003174 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196003175 Permease; Region: Permease; pfam02405 246196003176 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196003177 mce related protein; Region: MCE; pfam02470 246196003178 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196003179 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196003180 mce related protein; Region: MCE; pfam02470 246196003181 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196003182 mce related protein; Region: MCE; pfam02470 246196003183 mce related protein; Region: MCE; pfam02470 246196003184 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196003185 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196003186 mce related protein; Region: MCE; pfam02470 246196003187 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196003188 mce related protein; Region: MCE; pfam02470 246196003189 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 246196003190 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 246196003191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196003192 non-specific DNA binding site [nucleotide binding]; other site 246196003193 salt bridge; other site 246196003194 sequence-specific DNA binding site [nucleotide binding]; other site 246196003195 Cupin domain; Region: Cupin_2; pfam07883 246196003196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003197 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196003198 putative substrate translocation pore; other site 246196003199 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 246196003200 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196003201 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196003202 enoyl-CoA hydratase; Provisional; Region: PRK06494 246196003203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003204 substrate binding site [chemical binding]; other site 246196003205 oxyanion hole (OAH) forming residues; other site 246196003206 trimer interface [polypeptide binding]; other site 246196003207 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 246196003208 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 246196003209 inhibitor site; inhibition site 246196003210 active site 246196003211 dimer interface [polypeptide binding]; other site 246196003212 catalytic residue [active] 246196003213 short chain dehydrogenase; Provisional; Region: PRK06125 246196003214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196003215 NAD(P) binding site [chemical binding]; other site 246196003216 active site 246196003217 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196003218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196003219 NAD(P) binding site [chemical binding]; other site 246196003220 catalytic residues [active] 246196003221 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196003222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196003223 substrate binding pocket [chemical binding]; other site 246196003224 membrane-bound complex binding site; other site 246196003225 hinge residues; other site 246196003226 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196003227 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196003228 Walker A/P-loop; other site 246196003229 ATP binding site [chemical binding]; other site 246196003230 Q-loop/lid; other site 246196003231 ABC transporter signature motif; other site 246196003232 Walker B; other site 246196003233 D-loop; other site 246196003234 H-loop/switch region; other site 246196003235 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196003236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196003237 dimer interface [polypeptide binding]; other site 246196003238 conserved gate region; other site 246196003239 putative PBP binding loops; other site 246196003240 ABC-ATPase subunit interface; other site 246196003241 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196003242 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196003243 active site 246196003244 non-prolyl cis peptide bond; other site 246196003245 potential frameshift: common BLAST hit: gi|111021914|ref|YP_704886.1| major facilitator transporter 246196003246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 246196003247 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 246196003248 Cytochrome P450; Region: p450; cl12078 246196003249 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196003250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196003251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003252 putative substrate translocation pore; other site 246196003253 Low molecular weight phosphatase family; Region: LMWPc; cd00115 246196003254 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 246196003255 active site 246196003256 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 246196003257 arsenical-resistance protein; Region: acr3; TIGR00832 246196003258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196003259 dimerization interface [polypeptide binding]; other site 246196003260 putative DNA binding site [nucleotide binding]; other site 246196003261 putative Zn2+ binding site [ion binding]; other site 246196003262 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 246196003263 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196003264 putative metal binding site [ion binding]; other site 246196003265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196003266 dimerization interface [polypeptide binding]; other site 246196003267 putative DNA binding site [nucleotide binding]; other site 246196003268 putative Zn2+ binding site [ion binding]; other site 246196003269 PE-PPE domain; Region: PE-PPE; pfam08237 246196003270 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 246196003271 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 246196003272 Na binding site [ion binding]; other site 246196003273 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 246196003274 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 246196003275 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 246196003276 urocanate hydratase; Provisional; Region: PRK05414 246196003277 allantoate amidohydrolase; Reviewed; Region: PRK09290 246196003278 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 246196003279 active site 246196003280 metal binding site [ion binding]; metal-binding site 246196003281 dimer interface [polypeptide binding]; other site 246196003282 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 246196003283 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196003284 active site 246196003285 imidazolonepropionase; Provisional; Region: PRK14085 246196003286 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 246196003287 active site 246196003288 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 246196003289 active sites [active] 246196003290 tetramer interface [polypeptide binding]; other site 246196003291 Cutinase; Region: Cutinase; pfam01083 246196003292 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196003293 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 246196003294 AsnC family; Region: AsnC_trans_reg; pfam01037 246196003295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196003296 putative DNA binding site [nucleotide binding]; other site 246196003297 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 246196003298 putative Zn2+ binding site [ion binding]; other site 246196003299 AsnC family; Region: AsnC_trans_reg; pfam01037 246196003300 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196003301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196003302 active site 246196003303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196003304 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196003305 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196003306 active site 246196003307 ATP binding site [chemical binding]; other site 246196003308 substrate binding site [chemical binding]; other site 246196003309 activation loop (A-loop); other site 246196003310 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246196003311 Peptidase family M23; Region: Peptidase_M23; pfam01551 246196003312 TROVE domain; Region: TROVE; pfam05731 246196003313 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 246196003314 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196003315 substrate binding site [chemical binding]; other site 246196003316 activation loop (A-loop); other site 246196003317 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 246196003318 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196003319 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196003320 active site 246196003321 ATP binding site [chemical binding]; other site 246196003322 substrate binding site [chemical binding]; other site 246196003323 activation loop (A-loop); other site 246196003324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196003325 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196003326 substrate binding pocket [chemical binding]; other site 246196003327 membrane-bound complex binding site; other site 246196003328 hinge residues; other site 246196003329 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196003330 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 246196003331 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246196003332 dimer interface [polypeptide binding]; other site 246196003333 active site 246196003334 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 246196003335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003336 S-adenosylmethionine binding site [chemical binding]; other site 246196003337 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 246196003338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196003339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003340 S-adenosylmethionine binding site [chemical binding]; other site 246196003341 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246196003342 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196003343 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 246196003344 active site 246196003345 NYN domain; Region: NYN; pfam01936 246196003346 putative metal binding site [ion binding]; other site 246196003347 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246196003348 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196003349 putative di-iron ligands [ion binding]; other site 246196003350 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196003351 Cytochrome P450; Region: p450; cl12078 246196003352 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246196003353 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 246196003354 Thioredoxin; Region: Thioredoxin_4; cl17273 246196003355 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 246196003356 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 246196003357 putative ligand binding site [chemical binding]; other site 246196003358 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246196003359 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246196003360 Walker A/P-loop; other site 246196003361 ATP binding site [chemical binding]; other site 246196003362 Q-loop/lid; other site 246196003363 ABC transporter signature motif; other site 246196003364 Walker B; other site 246196003365 D-loop; other site 246196003366 H-loop/switch region; other site 246196003367 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196003368 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246196003369 Walker A/P-loop; other site 246196003370 ATP binding site [chemical binding]; other site 246196003371 Q-loop/lid; other site 246196003372 ABC transporter signature motif; other site 246196003373 Walker B; other site 246196003374 D-loop; other site 246196003375 H-loop/switch region; other site 246196003376 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196003377 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246196003378 TM-ABC transporter signature motif; other site 246196003379 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246196003380 TM-ABC transporter signature motif; other site 246196003381 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 246196003382 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196003383 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246196003384 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246196003385 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196003386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196003387 DNA-binding site [nucleotide binding]; DNA binding site 246196003388 UTRA domain; Region: UTRA; pfam07702 246196003389 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196003390 Sulfatase; Region: Sulfatase; pfam00884 246196003391 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 246196003392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196003393 Mg2+ binding site [ion binding]; other site 246196003394 G-X-G motif; other site 246196003395 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 246196003396 anchoring element; other site 246196003397 dimer interface [polypeptide binding]; other site 246196003398 ATP binding site [chemical binding]; other site 246196003399 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 246196003400 active site 246196003401 putative metal-binding site [ion binding]; other site 246196003402 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246196003403 Predicted membrane protein [Function unknown]; Region: COG2149 246196003404 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196003405 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 246196003406 substrate binding pocket [chemical binding]; other site 246196003407 membrane-bound complex binding site; other site 246196003408 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196003409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196003410 dimer interface [polypeptide binding]; other site 246196003411 conserved gate region; other site 246196003412 ABC-ATPase subunit interface; other site 246196003413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 246196003414 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196003415 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196003416 Walker A/P-loop; other site 246196003417 ATP binding site [chemical binding]; other site 246196003418 Q-loop/lid; other site 246196003419 ABC transporter signature motif; other site 246196003420 Walker B; other site 246196003421 D-loop; other site 246196003422 H-loop/switch region; other site 246196003423 high affinity sulphate transporter 1; Region: sulP; TIGR00815 246196003424 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246196003425 Sulfate transporter family; Region: Sulfate_transp; pfam00916 246196003426 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 246196003427 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 246196003428 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 246196003429 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246196003430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196003431 ATP binding site [chemical binding]; other site 246196003432 putative Mg++ binding site [ion binding]; other site 246196003433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196003434 nucleotide binding region [chemical binding]; other site 246196003435 ATP-binding site [chemical binding]; other site 246196003436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196003437 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196003438 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 246196003439 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196003440 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 246196003441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196003442 catalytic residue [active] 246196003443 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 246196003444 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 246196003445 Active Sites [active] 246196003446 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 246196003447 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 246196003448 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 246196003449 phosphoinositide binding site [chemical binding]; other site 246196003450 putative transposase OrfB; Reviewed; Region: PHA02517 246196003451 HTH-like domain; Region: HTH_21; pfam13276 246196003452 Integrase core domain; Region: rve; pfam00665 246196003453 Integrase core domain; Region: rve_3; cl15866 246196003454 Transposase; Region: HTH_Tnp_1; cl17663 246196003455 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196003456 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 246196003457 Part of AAA domain; Region: AAA_19; pfam13245 246196003458 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 246196003459 AAA domain; Region: AAA_12; pfam13087 246196003460 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 246196003461 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 246196003462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196003463 ATP binding site [chemical binding]; other site 246196003464 putative Mg++ binding site [ion binding]; other site 246196003465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 246196003466 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 246196003467 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 246196003468 Family description; Region: UvrD_C_2; pfam13538 246196003469 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196003470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196003471 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196003472 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 246196003473 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 246196003474 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246196003475 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 246196003476 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 246196003477 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 246196003478 active site 246196003479 catalytic residues [active] 246196003480 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 246196003481 nudix motif; other site 246196003482 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 246196003483 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 246196003484 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246196003485 active site 246196003486 metal binding site [ion binding]; metal-binding site 246196003487 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 246196003488 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 246196003489 active site 246196003490 catalytic residues [active] 246196003491 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196003492 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196003493 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196003494 active site 246196003495 Fic/DOC family; Region: Fic; cl00960 246196003496 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 246196003497 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 246196003498 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 246196003499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 246196003500 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 246196003501 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 246196003502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 246196003503 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 246196003504 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 246196003505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 246196003506 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 246196003507 putative active site [active] 246196003508 SEC-C motif; Region: SEC-C; pfam02810 246196003509 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196003510 Sulfatase; Region: Sulfatase; pfam00884 246196003511 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 246196003512 hydrophobic ligand binding site; other site 246196003513 Nuclease-related domain; Region: NERD; pfam08378 246196003514 Part of AAA domain; Region: AAA_19; pfam13245 246196003515 Family description; Region: UvrD_C_2; pfam13538 246196003516 Helix-turn-helix domain; Region: HTH_31; pfam13560 246196003517 sequence-specific DNA binding site [nucleotide binding]; other site 246196003518 salt bridge; other site 246196003519 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 246196003520 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196003521 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196003522 catalytic loop [active] 246196003523 iron binding site [ion binding]; other site 246196003524 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196003525 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196003526 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196003527 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196003528 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 246196003529 xanthine permease; Region: pbuX; TIGR03173 246196003530 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 246196003531 putative OHCU decarboxylase; Provisional; Region: PRK13798 246196003532 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 246196003533 active site 246196003534 homotetramer interface [polypeptide binding]; other site 246196003535 urate oxidase; Region: urate_oxi; TIGR03383 246196003536 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 246196003537 active site 246196003538 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 246196003539 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 246196003540 active site 246196003541 putative substrate binding pocket [chemical binding]; other site 246196003542 guanine deaminase; Provisional; Region: PRK09228 246196003543 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196003544 active site 246196003545 oxidase reductase; Provisional; Region: PTZ00273 246196003546 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196003547 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196003548 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196003549 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 246196003550 DNA binding residues [nucleotide binding] 246196003551 dimerization interface [polypeptide binding]; other site 246196003552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196003553 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196003554 non-specific DNA binding site [nucleotide binding]; other site 246196003555 salt bridge; other site 246196003556 sequence-specific DNA binding site [nucleotide binding]; other site 246196003557 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196003558 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196003559 active site 246196003560 catalytic tetrad [active] 246196003561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003563 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196003564 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196003565 NAD(P) binding site [chemical binding]; other site 246196003566 catalytic residues [active] 246196003567 EthD domain; Region: EthD; cl17553 246196003568 Predicted acyl esterases [General function prediction only]; Region: COG2936 246196003569 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 246196003570 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196003571 Predicted membrane protein [Function unknown]; Region: COG1297 246196003572 putative oligopeptide transporter, OPT family; Region: TIGR00733 246196003573 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 246196003574 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 246196003575 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246196003576 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246196003577 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 246196003578 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 246196003579 G1 box; other site 246196003580 putative GEF interaction site [polypeptide binding]; other site 246196003581 GTP/Mg2+ binding site [chemical binding]; other site 246196003582 Switch I region; other site 246196003583 G2 box; other site 246196003584 G3 box; other site 246196003585 Switch II region; other site 246196003586 G4 box; other site 246196003587 G5 box; other site 246196003588 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 246196003589 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196003590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196003591 DNA-binding site [nucleotide binding]; DNA binding site 246196003592 FCD domain; Region: FCD; pfam07729 246196003593 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 246196003594 active site 246196003595 catalytic site [active] 246196003596 Zn binding site [ion binding]; other site 246196003597 tetramer interface [polypeptide binding]; other site 246196003598 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246196003599 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196003600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003601 D-galactonate transporter; Region: 2A0114; TIGR00893 246196003602 putative substrate translocation pore; other site 246196003603 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196003604 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196003605 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 246196003606 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 246196003607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196003608 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196003609 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 246196003610 AAA domain; Region: AAA_30; pfam13604 246196003611 Family description; Region: UvrD_C_2; pfam13538 246196003612 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 246196003613 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 246196003614 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 246196003615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003616 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196003617 putative substrate translocation pore; other site 246196003618 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196003619 MarR family; Region: MarR_2; pfam12802 246196003620 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196003621 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003622 substrate binding site [chemical binding]; other site 246196003623 oxyanion hole (OAH) forming residues; other site 246196003624 trimer interface [polypeptide binding]; other site 246196003625 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 246196003626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246196003627 Rrf2 family protein; Region: rrf2_super; TIGR00738 246196003628 Transcriptional regulator; Region: Rrf2; cl17282 246196003629 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 246196003630 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 246196003631 heme-binding site [chemical binding]; other site 246196003632 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 246196003633 FAD binding pocket [chemical binding]; other site 246196003634 FAD binding motif [chemical binding]; other site 246196003635 phosphate binding motif [ion binding]; other site 246196003636 beta-alpha-beta structure motif; other site 246196003637 NAD binding pocket [chemical binding]; other site 246196003638 Heme binding pocket [chemical binding]; other site 246196003639 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 246196003640 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196003641 active site 246196003642 catalytic site [active] 246196003643 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 246196003644 active site 246196003645 catalytic site [active] 246196003646 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196003647 active site 246196003648 catalytic site [active] 246196003649 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 246196003650 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 246196003651 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 246196003652 putative homodimer interface [polypeptide binding]; other site 246196003653 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 246196003654 heterodimer interface [polypeptide binding]; other site 246196003655 homodimer interface [polypeptide binding]; other site 246196003656 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 246196003657 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 246196003658 23S rRNA interface [nucleotide binding]; other site 246196003659 L7/L12 interface [polypeptide binding]; other site 246196003660 putative thiostrepton binding site; other site 246196003661 L25 interface [polypeptide binding]; other site 246196003662 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 246196003663 mRNA/rRNA interface [nucleotide binding]; other site 246196003664 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 246196003665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196003666 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196003667 DNA binding residues [nucleotide binding] 246196003668 YCII-related domain; Region: YCII; cl00999 246196003669 YCII-related domain; Region: YCII; cl00999 246196003670 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 246196003671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003672 S-adenosylmethionine binding site [chemical binding]; other site 246196003673 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 246196003674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003675 S-adenosylmethionine binding site [chemical binding]; other site 246196003676 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196003677 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 246196003678 ABC1 family; Region: ABC1; pfam03109 246196003679 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 246196003680 active site 246196003681 ATP binding site [chemical binding]; other site 246196003682 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 246196003683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003685 Protein of unknown function (DUF664); Region: DUF664; pfam04978 246196003686 DinB superfamily; Region: DinB_2; pfam12867 246196003687 Predicted transcriptional regulator [Transcription]; Region: COG2378 246196003688 HTH domain; Region: HTH_11; pfam08279 246196003689 WYL domain; Region: WYL; pfam13280 246196003690 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246196003691 putative catalytic site [active] 246196003692 putative metal binding site [ion binding]; other site 246196003693 putative phosphate binding site [ion binding]; other site 246196003694 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 246196003695 active site 246196003696 catalytic site [active] 246196003697 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 246196003698 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 246196003699 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 246196003700 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196003701 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196003702 nucleotide binding site [chemical binding]; other site 246196003703 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 246196003704 23S rRNA interface [nucleotide binding]; other site 246196003705 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 246196003706 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 246196003707 core dimer interface [polypeptide binding]; other site 246196003708 peripheral dimer interface [polypeptide binding]; other site 246196003709 L10 interface [polypeptide binding]; other site 246196003710 L11 interface [polypeptide binding]; other site 246196003711 putative EF-Tu interaction site [polypeptide binding]; other site 246196003712 putative EF-G interaction site [polypeptide binding]; other site 246196003713 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 246196003714 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 246196003715 Walker A/P-loop; other site 246196003716 ATP binding site [chemical binding]; other site 246196003717 Q-loop/lid; other site 246196003718 ABC transporter signature motif; other site 246196003719 Walker B; other site 246196003720 D-loop; other site 246196003721 H-loop/switch region; other site 246196003722 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 246196003723 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 246196003724 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 246196003725 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 246196003726 RPB10 interaction site [polypeptide binding]; other site 246196003727 RPB1 interaction site [polypeptide binding]; other site 246196003728 RPB11 interaction site [polypeptide binding]; other site 246196003729 RPB3 interaction site [polypeptide binding]; other site 246196003730 RPB12 interaction site [polypeptide binding]; other site 246196003731 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 246196003732 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 246196003733 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 246196003734 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 246196003735 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 246196003736 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 246196003737 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 246196003738 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 246196003739 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 246196003740 DNA binding site [nucleotide binding] 246196003741 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 246196003742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196003743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196003744 DNA binding site [nucleotide binding] 246196003745 domain linker motif; other site 246196003746 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196003747 ligand binding site [chemical binding]; other site 246196003748 dimerization interface [polypeptide binding]; other site 246196003749 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196003750 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196003751 NAD(P) binding site [chemical binding]; other site 246196003752 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 246196003753 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 246196003754 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196003755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196003756 Walker A/P-loop; other site 246196003757 ATP binding site [chemical binding]; other site 246196003758 Q-loop/lid; other site 246196003759 ABC transporter signature motif; other site 246196003760 Walker B; other site 246196003761 D-loop; other site 246196003762 H-loop/switch region; other site 246196003763 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196003764 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196003765 TM-ABC transporter signature motif; other site 246196003766 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 246196003767 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 246196003768 putative ligand binding site [chemical binding]; other site 246196003769 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 246196003770 intersubunit interface [polypeptide binding]; other site 246196003771 active site 246196003772 zinc binding site [ion binding]; other site 246196003773 Na+ binding site [ion binding]; other site 246196003774 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196003775 nucleotide binding site [chemical binding]; other site 246196003776 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196003777 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 246196003778 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196003779 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 246196003780 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 246196003781 putative substrate binding site [chemical binding]; other site 246196003782 putative ATP binding site [chemical binding]; other site 246196003783 Predicted dehydrogenase [General function prediction only]; Region: COG0579 246196003784 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246196003785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003787 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196003788 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196003789 endonuclease IV; Provisional; Region: PRK01060 246196003790 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 246196003791 AP (apurinic/apyrimidinic) site pocket; other site 246196003792 DNA interaction; other site 246196003793 Metal-binding active site; metal-binding site 246196003794 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 246196003795 active site 246196003796 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 246196003797 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 246196003798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196003799 active site 246196003800 enoyl-CoA hydratase; Provisional; Region: PRK12478 246196003801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003802 substrate binding site [chemical binding]; other site 246196003803 oxyanion hole (OAH) forming residues; other site 246196003804 trimer interface [polypeptide binding]; other site 246196003805 PaaX-like protein; Region: PaaX; pfam07848 246196003806 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 246196003807 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196003808 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003809 substrate binding site [chemical binding]; other site 246196003810 oxyanion hole (OAH) forming residues; other site 246196003811 trimer interface [polypeptide binding]; other site 246196003812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196003813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196003814 LysR substrate binding domain; Region: LysR_substrate; pfam03466 246196003815 dimerization interface [polypeptide binding]; other site 246196003816 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 246196003817 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 246196003818 putative active site [active] 246196003819 metal binding site [ion binding]; metal-binding site 246196003820 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 246196003821 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 246196003822 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196003823 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196003824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003826 WHG domain; Region: WHG; pfam13305 246196003827 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 246196003828 S17 interaction site [polypeptide binding]; other site 246196003829 S8 interaction site; other site 246196003830 16S rRNA interaction site [nucleotide binding]; other site 246196003831 streptomycin interaction site [chemical binding]; other site 246196003832 23S rRNA interaction site [nucleotide binding]; other site 246196003833 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 246196003834 30S ribosomal protein S7; Validated; Region: PRK05302 246196003835 elongation factor G; Reviewed; Region: PRK00007 246196003836 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 246196003837 G1 box; other site 246196003838 putative GEF interaction site [polypeptide binding]; other site 246196003839 GTP/Mg2+ binding site [chemical binding]; other site 246196003840 Switch I region; other site 246196003841 G2 box; other site 246196003842 G3 box; other site 246196003843 Switch II region; other site 246196003844 G4 box; other site 246196003845 G5 box; other site 246196003846 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 246196003847 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 246196003848 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 246196003849 elongation factor Tu; Reviewed; Region: PRK00049 246196003850 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 246196003851 G1 box; other site 246196003852 GEF interaction site [polypeptide binding]; other site 246196003853 GTP/Mg2+ binding site [chemical binding]; other site 246196003854 Switch I region; other site 246196003855 G2 box; other site 246196003856 G3 box; other site 246196003857 Switch II region; other site 246196003858 G4 box; other site 246196003859 G5 box; other site 246196003860 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 246196003861 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 246196003862 Antibiotic Binding Site [chemical binding]; other site 246196003863 Cutinase; Region: Cutinase; pfam01083 246196003864 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196003865 Short C-terminal domain; Region: SHOCT; pfam09851 246196003866 potential frameshift: common BLAST hit: gi|116624869|ref|YP_827025.1| Na+/H+ antiporter NhaC 246196003867 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 246196003868 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 246196003869 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 246196003870 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 246196003871 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 246196003872 arginine deiminase; Provisional; Region: PRK01388 246196003873 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196003874 classical (c) SDRs; Region: SDR_c; cd05233 246196003875 NAD(P) binding site [chemical binding]; other site 246196003876 active site 246196003877 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196003878 Ligand Binding Site [chemical binding]; other site 246196003879 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196003880 Ligand Binding Site [chemical binding]; other site 246196003881 amino acid transporter; Region: 2A0306; TIGR00909 246196003882 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 246196003883 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 246196003884 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196003885 inhibitor-cofactor binding pocket; inhibition site 246196003886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196003887 catalytic residue [active] 246196003888 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 246196003889 Amidinotransferase; Region: Amidinotransf; pfam02274 246196003890 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 246196003891 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 246196003892 putative DNA binding site [nucleotide binding]; other site 246196003893 putative Zn2+ binding site [ion binding]; other site 246196003894 AsnC family; Region: AsnC_trans_reg; pfam01037 246196003895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 246196003896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196003897 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 246196003898 putative dimer interface [polypeptide binding]; other site 246196003899 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196003900 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196003901 active site 246196003902 metal binding site [ion binding]; metal-binding site 246196003903 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246196003904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196003905 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246196003906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196003907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196003908 DNA binding residues [nucleotide binding] 246196003909 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 246196003910 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 246196003911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003912 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 246196003913 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 246196003914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196003915 FeS/SAM binding site; other site 246196003916 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246196003917 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 246196003918 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246196003919 phosphate binding site [ion binding]; other site 246196003920 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 246196003921 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 246196003922 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 246196003923 Probable Catalytic site; other site 246196003924 metal-binding site 246196003925 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 246196003926 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196003927 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 246196003928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003929 putative substrate translocation pore; other site 246196003930 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196003931 Cytochrome P450; Region: p450; cl12078 246196003932 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196003933 Cytochrome P450; Region: p450; cl12078 246196003934 Carboxylesterase family; Region: COesterase; pfam00135 246196003935 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196003936 substrate binding pocket [chemical binding]; other site 246196003937 catalytic triad [active] 246196003938 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196003939 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 246196003940 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 246196003941 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 246196003942 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 246196003943 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 246196003944 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 246196003945 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 246196003946 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 246196003947 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 246196003948 putative translocon binding site; other site 246196003949 protein-rRNA interface [nucleotide binding]; other site 246196003950 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 246196003951 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 246196003952 G-X-X-G motif; other site 246196003953 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 246196003954 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 246196003955 23S rRNA interface [nucleotide binding]; other site 246196003956 5S rRNA interface [nucleotide binding]; other site 246196003957 putative antibiotic binding site [chemical binding]; other site 246196003958 L25 interface [polypeptide binding]; other site 246196003959 L27 interface [polypeptide binding]; other site 246196003960 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 246196003961 putative translocon interaction site; other site 246196003962 23S rRNA interface [nucleotide binding]; other site 246196003963 signal recognition particle (SRP54) interaction site; other site 246196003964 L23 interface [polypeptide binding]; other site 246196003965 trigger factor interaction site; other site 246196003966 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 246196003967 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246196003968 nudix motif; other site 246196003969 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 246196003970 DNA binding residues [nucleotide binding] 246196003971 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196003972 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 246196003973 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246196003974 Sulfate transporter family; Region: Sulfate_transp; pfam00916 246196003975 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 246196003976 Fasciclin domain; Region: Fasciclin; cl02663 246196003977 Fasciclin domain; Region: Fasciclin; pfam02469 246196003978 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196003979 Sulfatase; Region: Sulfatase; pfam00884 246196003980 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 246196003981 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246196003982 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246196003983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003984 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196003985 Domain of unknown function (DUF336); Region: DUF336; pfam03928 246196003986 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 246196003987 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196003988 iron-sulfur cluster [ion binding]; other site 246196003989 [2Fe-2S] cluster binding site [ion binding]; other site 246196003990 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 246196003991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196003992 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196003993 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196003994 NAD(P) binding site [chemical binding]; other site 246196003995 catalytic residues [active] 246196003996 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 246196003997 [2Fe-2S] cluster binding site [ion binding]; other site 246196003998 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 246196003999 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 246196004000 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246196004001 homotrimer interaction site [polypeptide binding]; other site 246196004002 putative active site [active] 246196004003 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 246196004004 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 246196004005 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 246196004006 RNA binding site [nucleotide binding]; other site 246196004007 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 246196004008 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 246196004009 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 246196004010 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 246196004011 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 246196004012 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 246196004013 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 246196004014 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 246196004015 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 246196004016 5S rRNA interface [nucleotide binding]; other site 246196004017 L27 interface [polypeptide binding]; other site 246196004018 23S rRNA interface [nucleotide binding]; other site 246196004019 L5 interface [polypeptide binding]; other site 246196004020 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 246196004021 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 246196004022 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 246196004023 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 246196004024 23S rRNA binding site [nucleotide binding]; other site 246196004025 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 246196004026 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196004027 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196004028 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 246196004029 tandem repeat interface [polypeptide binding]; other site 246196004030 oligomer interface [polypeptide binding]; other site 246196004031 active site residues [active] 246196004032 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 246196004033 tandem repeat interface [polypeptide binding]; other site 246196004034 oligomer interface [polypeptide binding]; other site 246196004035 active site residues [active] 246196004036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196004037 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196004038 putative substrate translocation pore; other site 246196004039 LysE type translocator; Region: LysE; cl00565 246196004040 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004041 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196004042 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004043 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196004044 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004045 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196004046 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004047 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196004048 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 246196004049 SecY translocase; Region: SecY; pfam00344 246196004050 adenylate kinase; Reviewed; Region: adk; PRK00279 246196004051 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 246196004052 AMP-binding site [chemical binding]; other site 246196004053 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 246196004054 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246196004055 active site 246196004056 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 246196004057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004058 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004059 DNA binding residues [nucleotide binding] 246196004060 Putative zinc-finger; Region: zf-HC2; pfam13490 246196004061 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 246196004062 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196004063 PYR/PP interface [polypeptide binding]; other site 246196004064 dimer interface [polypeptide binding]; other site 246196004065 TPP binding site [chemical binding]; other site 246196004066 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 246196004067 TPP-binding site [chemical binding]; other site 246196004068 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 246196004069 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246196004070 active site 246196004071 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 246196004072 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196004073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004074 homodimer interface [polypeptide binding]; other site 246196004075 catalytic residue [active] 246196004076 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196004077 MarR family; Region: MarR; pfam01047 246196004078 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196004079 GAF domain; Region: GAF; pfam01590 246196004080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196004081 Histidine kinase; Region: HisKA_3; pfam07730 246196004082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196004083 ATP binding site [chemical binding]; other site 246196004084 Mg2+ binding site [ion binding]; other site 246196004085 G-X-G motif; other site 246196004086 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196004087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196004088 active site 246196004089 phosphorylation site [posttranslational modification] 246196004090 intermolecular recognition site; other site 246196004091 dimerization interface [polypeptide binding]; other site 246196004092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196004093 DNA binding residues [nucleotide binding] 246196004094 dimerization interface [polypeptide binding]; other site 246196004095 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 246196004096 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196004097 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 246196004098 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196004099 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 246196004100 substrate binding pocket [chemical binding]; other site 246196004101 FAD binding site [chemical binding]; other site 246196004102 catalytic base [active] 246196004103 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 246196004104 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 246196004105 tetrameric interface [polypeptide binding]; other site 246196004106 NAD binding site [chemical binding]; other site 246196004107 catalytic residues [active] 246196004108 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196004109 hypothetical protein; Provisional; Region: PRK06184 246196004110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004112 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004113 Leucine carboxyl methyltransferase; Region: LCM; cl01306 246196004114 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196004115 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196004116 Walker A/P-loop; other site 246196004117 ATP binding site [chemical binding]; other site 246196004118 Q-loop/lid; other site 246196004119 ABC transporter signature motif; other site 246196004120 Walker B; other site 246196004121 D-loop; other site 246196004122 H-loop/switch region; other site 246196004123 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 246196004124 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 246196004125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004126 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246196004127 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 246196004128 homodimer interface [polypeptide binding]; other site 246196004129 homotetramer interface [polypeptide binding]; other site 246196004130 active site pocket [active] 246196004131 cleavage site 246196004132 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196004133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004135 FMN binding site [chemical binding]; other site 246196004136 Nitroreductase family; Region: Nitroreductase; pfam00881 246196004137 dimer interface [polypeptide binding]; other site 246196004138 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 246196004139 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 246196004140 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 246196004141 NAD binding site [chemical binding]; other site 246196004142 substrate binding site [chemical binding]; other site 246196004143 homodimer interface [polypeptide binding]; other site 246196004144 active site 246196004145 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196004146 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 246196004147 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196004148 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 246196004149 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196004150 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196004151 ligand binding site [chemical binding]; other site 246196004152 flexible hinge region; other site 246196004153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196004154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196004155 ATP binding site [chemical binding]; other site 246196004156 Mg2+ binding site [ion binding]; other site 246196004157 G-X-G motif; other site 246196004158 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246196004159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196004160 active site 246196004161 phosphorylation site [posttranslational modification] 246196004162 intermolecular recognition site; other site 246196004163 dimerization interface [polypeptide binding]; other site 246196004164 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 246196004165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196004166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 246196004167 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 246196004168 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 246196004169 rRNA binding site [nucleotide binding]; other site 246196004170 predicted 30S ribosome binding site; other site 246196004171 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 246196004172 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 246196004173 30S ribosomal protein S13; Region: bact_S13; TIGR03631 246196004174 30S ribosomal protein S11; Validated; Region: PRK05309 246196004175 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 246196004176 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 246196004177 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196004178 RNA binding surface [nucleotide binding]; other site 246196004179 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 246196004180 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 246196004181 alphaNTD homodimer interface [polypeptide binding]; other site 246196004182 alphaNTD - beta interaction site [polypeptide binding]; other site 246196004183 alphaNTD - beta' interaction site [polypeptide binding]; other site 246196004184 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 246196004185 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 246196004186 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 246196004187 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 246196004188 dimerization interface 3.5A [polypeptide binding]; other site 246196004189 active site 246196004190 Cutinase; Region: Cutinase; pfam01083 246196004191 Cutinase; Region: Cutinase; pfam01083 246196004192 Cutinase; Region: Cutinase; pfam01083 246196004193 EamA-like transporter family; Region: EamA; pfam00892 246196004194 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 246196004195 EamA-like transporter family; Region: EamA; pfam00892 246196004196 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196004197 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196004198 Uncharacterized conserved protein [Function unknown]; Region: COG1359 246196004199 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 246196004200 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 246196004201 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 246196004202 active site 246196004203 catalytic residues [active] 246196004204 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 246196004205 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 246196004206 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196004207 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 246196004208 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196004209 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196004210 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 246196004211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 246196004212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 246196004213 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246196004214 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246196004215 ATP binding site [chemical binding]; other site 246196004216 Mg++ binding site [ion binding]; other site 246196004217 motif III; other site 246196004218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196004219 nucleotide binding region [chemical binding]; other site 246196004220 ATP-binding site [chemical binding]; other site 246196004221 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 246196004222 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 246196004223 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196004224 NAD(P) binding site [chemical binding]; other site 246196004225 catalytic residues [active] 246196004226 Domain of unknown function (DUF336); Region: DUF336; pfam03928 246196004227 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 246196004228 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 246196004229 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 246196004230 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 246196004231 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 246196004232 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 246196004233 alpha-beta subunit interface [polypeptide binding]; other site 246196004234 alpha-gamma subunit interface [polypeptide binding]; other site 246196004235 active site 246196004236 substrate and K+ binding site; other site 246196004237 K+ binding site [ion binding]; other site 246196004238 cobalamin binding site [chemical binding]; other site 246196004239 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 246196004240 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 246196004241 ethanolamine permease; Region: 2A0305; TIGR00908 246196004242 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 246196004243 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 246196004244 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 246196004245 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 246196004246 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 246196004247 23S rRNA interface [nucleotide binding]; other site 246196004248 L3 interface [polypeptide binding]; other site 246196004249 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 246196004250 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 246196004251 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 246196004252 active site 246196004253 substrate binding site [chemical binding]; other site 246196004254 metal binding site [ion binding]; metal-binding site 246196004255 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196004256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196004257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196004258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196004259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196004260 short chain dehydrogenase; Provisional; Region: PRK07041 246196004261 NAD(P) binding site [chemical binding]; other site 246196004262 active site 246196004263 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 246196004264 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 246196004265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004267 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246196004268 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 246196004269 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196004270 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246196004271 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246196004272 glutaminase active site [active] 246196004273 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196004274 dimer interface [polypeptide binding]; other site 246196004275 active site 246196004276 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246196004277 dimer interface [polypeptide binding]; other site 246196004278 active site 246196004279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196004280 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196004281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196004282 DNA-binding site [nucleotide binding]; DNA binding site 246196004283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196004284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004285 homodimer interface [polypeptide binding]; other site 246196004286 catalytic residue [active] 246196004287 Uncharacterized conserved protein [Function unknown]; Region: COG0062 246196004288 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 246196004289 putative substrate binding site [chemical binding]; other site 246196004290 putative ATP binding site [chemical binding]; other site 246196004291 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 246196004292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004293 catalytic residue [active] 246196004294 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 246196004295 alanine racemase; Reviewed; Region: alr; PRK00053 246196004296 active site 246196004297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196004298 dimer interface [polypeptide binding]; other site 246196004299 substrate binding site [chemical binding]; other site 246196004300 catalytic residues [active] 246196004301 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196004302 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196004303 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196004304 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 246196004305 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 246196004306 Glycoprotease family; Region: Peptidase_M22; pfam00814 246196004307 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 246196004308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196004309 Coenzyme A binding pocket [chemical binding]; other site 246196004310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196004311 UGMP family protein; Validated; Region: PRK09604 246196004312 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 246196004313 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 246196004314 oligomerisation interface [polypeptide binding]; other site 246196004315 mobile loop; other site 246196004316 roof hairpin; other site 246196004317 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 246196004318 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246196004319 ring oligomerisation interface [polypeptide binding]; other site 246196004320 ATP/Mg binding site [chemical binding]; other site 246196004321 stacking interactions; other site 246196004322 hinge regions; other site 246196004323 Cupin domain; Region: Cupin_2; pfam07883 246196004324 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196004325 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196004326 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196004327 enoyl-CoA hydratase; Validated; Region: PRK08139 246196004328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196004329 substrate binding site [chemical binding]; other site 246196004330 oxyanion hole (OAH) forming residues; other site 246196004331 trimer interface [polypeptide binding]; other site 246196004332 short chain dehydrogenase; Validated; Region: PRK08264 246196004333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196004334 NAD(P) binding site [chemical binding]; other site 246196004335 active site 246196004336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004338 Transcription factor WhiB; Region: Whib; pfam02467 246196004339 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 246196004340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004342 DNA binding residues [nucleotide binding] 246196004343 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 246196004344 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246196004345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 246196004346 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 246196004347 active site 246196004348 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 246196004349 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246196004350 phosphate binding site [ion binding]; other site 246196004351 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246196004352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196004353 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196004354 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 246196004355 PhoU domain; Region: PhoU; pfam01895 246196004356 PhoU domain; Region: PhoU; pfam01895 246196004357 benzoylformate decarboxylase; Reviewed; Region: PRK07092 246196004358 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196004359 PYR/PP interface [polypeptide binding]; other site 246196004360 dimer interface [polypeptide binding]; other site 246196004361 TPP binding site [chemical binding]; other site 246196004362 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196004363 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 246196004364 TPP-binding site [chemical binding]; other site 246196004365 dimer interface [polypeptide binding]; other site 246196004366 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 246196004367 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 246196004368 hexamer interface [polypeptide binding]; other site 246196004369 active site 2 [active] 246196004370 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 246196004371 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 246196004372 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 246196004373 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 246196004374 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 246196004375 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 246196004376 GMP synthase; Reviewed; Region: guaA; PRK00074 246196004377 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 246196004378 AMP/PPi binding site [chemical binding]; other site 246196004379 candidate oxyanion hole; other site 246196004380 catalytic triad [active] 246196004381 potential glutamine specificity residues [chemical binding]; other site 246196004382 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 246196004383 ATP Binding subdomain [chemical binding]; other site 246196004384 Ligand Binding sites [chemical binding]; other site 246196004385 Dimerization subdomain; other site 246196004386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004388 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196004389 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196004390 substrate binding pocket [chemical binding]; other site 246196004391 membrane-bound complex binding site; other site 246196004392 hinge residues; other site 246196004393 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246196004394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196004395 dimer interface [polypeptide binding]; other site 246196004396 conserved gate region; other site 246196004397 putative PBP binding loops; other site 246196004398 ABC-ATPase subunit interface; other site 246196004399 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196004400 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196004401 Walker A/P-loop; other site 246196004402 ATP binding site [chemical binding]; other site 246196004403 Q-loop/lid; other site 246196004404 ABC transporter signature motif; other site 246196004405 Walker B; other site 246196004406 D-loop; other site 246196004407 H-loop/switch region; other site 246196004408 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196004409 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 246196004410 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 246196004411 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 246196004412 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; pfam09286 246196004413 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 246196004414 active site 246196004415 catalytic triad [active] 246196004416 calcium binding site [ion binding]; other site 246196004417 DNA Polymerase Y-family; Region: PolY_like; cd03468 246196004418 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 246196004419 DNA binding site [nucleotide binding] 246196004420 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 246196004421 active site 246196004422 short chain dehydrogenase; Provisional; Region: PRK07201 246196004423 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 246196004424 putative NAD(P) binding site [chemical binding]; other site 246196004425 active site 246196004426 putative substrate binding site [chemical binding]; other site 246196004427 classical (c) SDRs; Region: SDR_c; cd05233 246196004428 NAD(P) binding site [chemical binding]; other site 246196004429 active site 246196004430 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 246196004431 Ligand Binding Site [chemical binding]; other site 246196004432 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196004433 Ligand Binding Site [chemical binding]; other site 246196004434 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196004435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196004436 salt bridge; other site 246196004437 non-specific DNA binding site [nucleotide binding]; other site 246196004438 sequence-specific DNA binding site [nucleotide binding]; other site 246196004439 short chain dehydrogenase; Provisional; Region: PRK06180 246196004440 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196004441 NADP binding site [chemical binding]; other site 246196004442 active site 246196004443 steroid binding site; other site 246196004444 short chain dehydrogenase; Provisional; Region: PRK07478 246196004445 classical (c) SDRs; Region: SDR_c; cd05233 246196004446 NAD(P) binding site [chemical binding]; other site 246196004447 active site 246196004448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196004449 salt bridge; other site 246196004450 non-specific DNA binding site [nucleotide binding]; other site 246196004451 sequence-specific DNA binding site [nucleotide binding]; other site 246196004452 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 246196004453 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 246196004454 active site 246196004455 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 246196004456 generic binding surface II; other site 246196004457 generic binding surface I; other site 246196004458 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 246196004459 FMN binding site [chemical binding]; other site 246196004460 dimer interface [polypeptide binding]; other site 246196004461 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 246196004462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196004463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196004464 ATP binding site [chemical binding]; other site 246196004465 Mg2+ binding site [ion binding]; other site 246196004466 G-X-G motif; other site 246196004467 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 246196004468 Protein of unknown function (DUF742); Region: DUF742; pfam05331 246196004469 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246196004470 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 246196004471 G1 box; other site 246196004472 GTP/Mg2+ binding site [chemical binding]; other site 246196004473 G2 box; other site 246196004474 Switch I region; other site 246196004475 G3 box; other site 246196004476 Switch II region; other site 246196004477 G4 box; other site 246196004478 G5 box; other site 246196004479 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246196004480 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246196004481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246196004482 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196004483 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196004484 phosphopeptide binding site; other site 246196004485 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196004486 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196004487 phosphopeptide binding site; other site 246196004488 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196004489 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 246196004490 Walker A/P-loop; other site 246196004491 ATP binding site [chemical binding]; other site 246196004492 Q-loop/lid; other site 246196004493 ABC transporter signature motif; other site 246196004494 Walker B; other site 246196004495 D-loop; other site 246196004496 H-loop/switch region; other site 246196004497 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246196004498 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196004499 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196004500 PQQ-like domain; Region: PQQ_2; pfam13360 246196004501 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 246196004502 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 246196004503 active site 246196004504 FMN binding site [chemical binding]; other site 246196004505 substrate binding site [chemical binding]; other site 246196004506 putative catalytic residue [active] 246196004507 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 246196004508 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 246196004509 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 246196004510 homodimer interface [polypeptide binding]; other site 246196004511 NADP binding site [chemical binding]; other site 246196004512 substrate binding site [chemical binding]; other site 246196004513 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 246196004514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196004515 S-adenosylmethionine binding site [chemical binding]; other site 246196004516 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 246196004517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004518 hypothetical protein; Provisional; Region: PRK08244 246196004519 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196004520 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196004521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196004522 S-adenosylmethionine binding site [chemical binding]; other site 246196004523 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 246196004524 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 246196004525 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 246196004526 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246196004527 homodimer interface [polypeptide binding]; other site 246196004528 substrate-cofactor binding pocket; other site 246196004529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004530 catalytic residue [active] 246196004531 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 246196004532 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 246196004533 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196004534 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 246196004535 putative active site [active] 246196004536 putative catalytic site [active] 246196004537 putative DNA binding site [nucleotide binding]; other site 246196004538 putative phosphate binding site [ion binding]; other site 246196004539 metal binding site A [ion binding]; metal-binding site 246196004540 putative AP binding site [nucleotide binding]; other site 246196004541 putative metal binding site B [ion binding]; other site 246196004542 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 246196004543 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 246196004544 active site 246196004545 HIGH motif; other site 246196004546 dimer interface [polypeptide binding]; other site 246196004547 KMSKS motif; other site 246196004548 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 246196004549 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 246196004550 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 246196004551 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196004552 FMN binding site [chemical binding]; other site 246196004553 substrate binding site [chemical binding]; other site 246196004554 putative catalytic residue [active] 246196004555 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 246196004556 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 246196004557 hypothetical protein; Provisional; Region: PRK06541 246196004558 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196004559 inhibitor-cofactor binding pocket; inhibition site 246196004560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004561 catalytic residue [active] 246196004562 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196004563 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 246196004564 AsnC family; Region: AsnC_trans_reg; pfam01037 246196004565 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 246196004566 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196004567 NAD(P) binding site [chemical binding]; other site 246196004568 catalytic residues [active] 246196004569 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 246196004570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004571 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196004572 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 246196004573 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196004574 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246196004575 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 246196004576 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 246196004577 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 246196004578 L-aspartate oxidase; Provisional; Region: PRK06175 246196004579 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196004580 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 246196004581 putative Iron-sulfur protein interface [polypeptide binding]; other site 246196004582 putative proximal heme binding site [chemical binding]; other site 246196004583 putative SdhC-like subunit interface [polypeptide binding]; other site 246196004584 putative distal heme binding site [chemical binding]; other site 246196004585 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 246196004586 putative Iron-sulfur protein interface [polypeptide binding]; other site 246196004587 putative proximal heme binding site [chemical binding]; other site 246196004588 putative SdhD-like interface [polypeptide binding]; other site 246196004589 putative distal heme binding site [chemical binding]; other site 246196004590 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 246196004591 active site 246196004592 catalytic motif [active] 246196004593 Zn binding site [ion binding]; other site 246196004594 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 246196004595 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 246196004596 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 246196004597 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 246196004598 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 246196004599 adenosine deaminase; Provisional; Region: PRK09358 246196004600 active site 246196004601 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 246196004602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196004603 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 246196004604 putative substrate binding pocket [chemical binding]; other site 246196004605 dimerization interface [polypeptide binding]; other site 246196004606 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 246196004607 Aspartase; Region: Aspartase; cd01357 246196004608 active sites [active] 246196004609 tetramer interface [polypeptide binding]; other site 246196004610 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 246196004611 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 246196004612 metal binding site [ion binding]; metal-binding site 246196004613 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 246196004614 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246196004615 homotrimer interaction site [polypeptide binding]; other site 246196004616 putative active site [active] 246196004617 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 246196004618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196004619 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196004620 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 246196004621 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196004622 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196004623 Cupin domain; Region: Cupin_2; cl17218 246196004624 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196004625 classical (c) SDRs; Region: SDR_c; cd05233 246196004626 NAD(P) binding site [chemical binding]; other site 246196004627 active site 246196004628 RNA polymerase sigma factor; Provisional; Region: PRK12533 246196004629 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004630 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004631 DNA binding residues [nucleotide binding] 246196004632 AAA ATPase domain; Region: AAA_16; pfam13191 246196004633 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196004634 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196004635 DNA binding residues [nucleotide binding] 246196004636 dimerization interface [polypeptide binding]; other site 246196004637 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 246196004638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004639 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196004640 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196004641 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 246196004642 L-aspartate oxidase; Provisional; Region: PRK06175 246196004643 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196004644 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196004645 active site 246196004646 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 246196004647 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 246196004648 active site 246196004649 substrate binding site [chemical binding]; other site 246196004650 metal binding site [ion binding]; metal-binding site 246196004651 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196004652 MarR family; Region: MarR_2; pfam12802 246196004653 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 246196004654 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 246196004655 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196004656 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196004657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004658 purine nucleoside phosphorylase; Provisional; Region: PRK08202 246196004659 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 246196004660 amidohydrolase; Region: amidohydrolases; TIGR01891 246196004661 metal binding site [ion binding]; metal-binding site 246196004662 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 246196004663 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 246196004664 metal binding site [ion binding]; metal-binding site 246196004665 putative dimer interface [polypeptide binding]; other site 246196004666 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 246196004667 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 246196004668 putative ligand binding site [chemical binding]; other site 246196004669 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 246196004670 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196004671 Walker A/P-loop; other site 246196004672 ATP binding site [chemical binding]; other site 246196004673 Q-loop/lid; other site 246196004674 ABC transporter signature motif; other site 246196004675 Walker B; other site 246196004676 D-loop; other site 246196004677 H-loop/switch region; other site 246196004678 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196004679 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196004680 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196004681 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196004682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196004683 TM-ABC transporter signature motif; other site 246196004684 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 246196004685 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196004686 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196004687 DNA binding site [nucleotide binding] 246196004688 domain linker motif; other site 246196004689 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 246196004690 dimerization interface (open form) [polypeptide binding]; other site 246196004691 ligand binding site [chemical binding]; other site 246196004692 dimerization interface (closed form) [polypeptide binding]; other site 246196004693 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196004694 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196004695 TM-ABC transporter signature motif; other site 246196004696 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196004697 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196004698 TM-ABC transporter signature motif; other site 246196004699 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196004700 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196004701 Walker A/P-loop; other site 246196004702 ATP binding site [chemical binding]; other site 246196004703 Q-loop/lid; other site 246196004704 ABC transporter signature motif; other site 246196004705 Walker B; other site 246196004706 D-loop; other site 246196004707 H-loop/switch region; other site 246196004708 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196004709 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196004710 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 246196004711 putative ligand binding site [chemical binding]; other site 246196004712 L-ribulokinase; Region: L-ribulokinase; TIGR01234 246196004713 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 246196004714 N- and C-terminal domain interface [polypeptide binding]; other site 246196004715 active site 246196004716 MgATP binding site [chemical binding]; other site 246196004717 catalytic site [active] 246196004718 metal binding site [ion binding]; metal-binding site 246196004719 carbohydrate binding site [chemical binding]; other site 246196004720 homodimer interface [polypeptide binding]; other site 246196004721 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 246196004722 intersubunit interface [polypeptide binding]; other site 246196004723 active site 246196004724 Zn2+ binding site [ion binding]; other site 246196004725 L-arabinose isomerase; Provisional; Region: PRK02929 246196004726 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 246196004727 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 246196004728 trimer interface [polypeptide binding]; other site 246196004729 putative substrate binding site [chemical binding]; other site 246196004730 putative metal binding site [ion binding]; other site 246196004731 Transposase; Region: HTH_Tnp_1; cl17663 246196004732 HTH-like domain; Region: HTH_21; pfam13276 246196004733 Integrase core domain; Region: rve; pfam00665 246196004734 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 246196004735 Helix-turn-helix domain; Region: HTH_38; pfam13936 246196004736 Integrase core domain; Region: rve; pfam00665 246196004737 Integrase core domain; Region: rve_3; cl15866 246196004738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196004739 Transposase; Region: HTH_Tnp_1; cl17663 246196004740 putative transposase OrfB; Reviewed; Region: PHA02517 246196004741 HTH-like domain; Region: HTH_21; pfam13276 246196004742 Integrase core domain; Region: rve; pfam00665 246196004743 Integrase core domain; Region: rve_3; pfam13683 246196004744 Integrase core domain; Region: rve; pfam00665 246196004745 Integrase core domain; Region: rve_3; pfam13683 246196004746 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196004747 Transposase; Region: HTH_Tnp_1; cl17663 246196004748 putative transposase OrfB; Reviewed; Region: PHA02517 246196004749 HTH-like domain; Region: HTH_21; pfam13276 246196004750 Integrase core domain; Region: rve; pfam00665 246196004751 Integrase core domain; Region: rve_3; pfam13683 246196004752 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196004753 Winged helix-turn helix; Region: HTH_29; pfam13551 246196004754 Homeodomain-like domain; Region: HTH_32; pfam13565 246196004755 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196004756 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196004757 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196004758 Transposase, Mutator family; Region: Transposase_mut; pfam00872 246196004759 MULE transposase domain; Region: MULE; pfam10551 246196004760 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 246196004761 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196004762 putative active site [active] 246196004763 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 246196004764 putative active site pocket [active] 246196004765 dimerization interface [polypeptide binding]; other site 246196004766 putative catalytic residue [active] 246196004767 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 246196004768 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 246196004769 NAD binding site [chemical binding]; other site 246196004770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196004771 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246196004772 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 246196004773 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246196004774 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 246196004775 probable active site [active] 246196004776 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196004777 classical (c) SDRs; Region: SDR_c; cd05233 246196004778 NAD(P) binding site [chemical binding]; other site 246196004779 active site 246196004780 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196004781 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196004782 substrate binding site [chemical binding]; other site 246196004783 oxyanion hole (OAH) forming residues; other site 246196004784 trimer interface [polypeptide binding]; other site 246196004785 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 246196004786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004787 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 246196004788 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196004789 FAD binding pocket [chemical binding]; other site 246196004790 FAD binding motif [chemical binding]; other site 246196004791 phosphate binding motif [ion binding]; other site 246196004792 beta-alpha-beta structure motif; other site 246196004793 NAD binding pocket [chemical binding]; other site 246196004794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196004795 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 246196004796 catalytic loop [active] 246196004797 iron binding site [ion binding]; other site 246196004798 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246196004799 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196004800 putative di-iron ligands [ion binding]; other site 246196004801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196004802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004804 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196004805 FAD binding domain; Region: FAD_binding_4; pfam01565 246196004806 Berberine and berberine like; Region: BBE; pfam08031 246196004807 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246196004808 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004810 DNA binding residues [nucleotide binding] 246196004811 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 246196004812 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196004813 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196004814 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196004815 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196004816 active site 246196004817 catalytic tetrad [active] 246196004818 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 246196004819 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 246196004820 Cupin domain; Region: Cupin_2; pfam07883 246196004821 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 246196004822 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 246196004823 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 246196004824 putative DNA binding site [nucleotide binding]; other site 246196004825 catalytic residue [active] 246196004826 putative H2TH interface [polypeptide binding]; other site 246196004827 putative catalytic residues [active] 246196004828 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246196004829 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246196004830 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196004831 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 246196004832 ATP binding site [chemical binding]; other site 246196004833 putative Mg++ binding site [ion binding]; other site 246196004834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196004835 nucleotide binding region [chemical binding]; other site 246196004836 ATP-binding site [chemical binding]; other site 246196004837 DEAD/H associated; Region: DEAD_assoc; pfam08494 246196004838 Lipase maturation factor; Region: LMF1; pfam06762 246196004839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196004840 NAD(P) binding site [chemical binding]; other site 246196004841 active site 246196004842 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 246196004843 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196004844 tetrameric interface [polypeptide binding]; other site 246196004845 NAD binding site [chemical binding]; other site 246196004846 catalytic residues [active] 246196004847 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 246196004848 AsnC family; Region: AsnC_trans_reg; pfam01037 246196004849 L-lysine aminotransferase; Provisional; Region: PRK08297 246196004850 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196004851 inhibitor-cofactor binding pocket; inhibition site 246196004852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004853 catalytic residue [active] 246196004854 Restriction endonuclease; Region: Mrr_cat; pfam04471 246196004855 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246196004856 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246196004857 putative methyltransferase; Provisional; Region: PRK14967 246196004858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196004859 S-adenosylmethionine binding site [chemical binding]; other site 246196004860 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 246196004861 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 246196004862 Cytochrome P450; Region: p450; cl12078 246196004863 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196004864 Cytochrome P450; Region: p450; cl12078 246196004865 ribonuclease Z; Reviewed; Region: PRK00055 246196004866 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 246196004867 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 246196004868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196004869 short chain dehydrogenase; Provisional; Region: PRK06701 246196004870 NAD(P) binding site [chemical binding]; other site 246196004871 active site 246196004872 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 246196004873 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 246196004874 active site 246196004875 DNA binding site [nucleotide binding] 246196004876 Int/Topo IB signature motif; other site 246196004877 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246196004878 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246196004879 anti sigma factor interaction site; other site 246196004880 regulatory phosphorylation site [posttranslational modification]; other site 246196004881 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 246196004882 Phospholipid methyltransferase; Region: PEMT; cl17370 246196004883 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 246196004884 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196004885 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196004886 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196004887 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 246196004888 putative NAD(P) binding site [chemical binding]; other site 246196004889 catalytic Zn binding site [ion binding]; other site 246196004890 structural Zn binding site [ion binding]; other site 246196004891 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 246196004892 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196004893 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 246196004894 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196004895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196004896 putative substrate translocation pore; other site 246196004897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196004898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196004899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196004900 dimerization interface [polypeptide binding]; other site 246196004901 ChaB; Region: ChaB; cl01887 246196004902 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 246196004903 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 246196004904 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 246196004905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004906 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246196004907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004908 DNA binding residues [nucleotide binding] 246196004909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196004910 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 246196004911 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196004912 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 246196004913 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196004914 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196004915 carboxyltransferase (CT) interaction site; other site 246196004916 biotinylation site [posttranslational modification]; other site 246196004917 Fe-S metabolism associated domain; Region: SufE; cl00951 246196004918 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 246196004919 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 246196004920 active site residue [active] 246196004921 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 246196004922 active site residue [active] 246196004923 Maf-like protein; Region: Maf; pfam02545 246196004924 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 246196004925 active site 246196004926 dimer interface [polypeptide binding]; other site 246196004927 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 246196004928 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196004929 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196004930 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196004931 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 246196004932 Bacterial PH domain; Region: DUF304; pfam03703 246196004933 Predicted membrane protein [Function unknown]; Region: COG2246 246196004934 GtrA-like protein; Region: GtrA; pfam04138 246196004935 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 246196004936 ATP-grasp domain; Region: ATP-grasp; pfam02222 246196004937 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 246196004938 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196004939 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 246196004940 FAD binding site [chemical binding]; other site 246196004941 homotetramer interface [polypeptide binding]; other site 246196004942 substrate binding pocket [chemical binding]; other site 246196004943 catalytic base [active] 246196004944 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 246196004945 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 246196004946 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 246196004947 TIGR03089 family protein; Region: TIGR03089 246196004948 Transcriptional regulator [Transcription]; Region: LytR; COG1316 246196004949 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196004950 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 246196004951 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 246196004952 NADP binding site [chemical binding]; other site 246196004953 active site 246196004954 putative substrate binding site [chemical binding]; other site 246196004955 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246196004956 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 246196004957 Probable Catalytic site; other site 246196004958 metal-binding site 246196004959 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 246196004960 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 246196004961 active site 246196004962 Substrate binding site; other site 246196004963 Mg++ binding site; other site 246196004964 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246196004965 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 246196004966 nudix motif; other site 246196004967 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 246196004968 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 246196004969 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 246196004970 putative FMN binding site [chemical binding]; other site 246196004971 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 246196004972 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 246196004973 phosphate binding site [ion binding]; other site 246196004974 dimer interface [polypeptide binding]; other site 246196004975 substrate binding site [chemical binding]; other site 246196004976 Transcription factor WhiB; Region: Whib; pfam02467 246196004977 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 246196004978 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 246196004979 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 246196004980 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 246196004981 active site 246196004982 substrate binding site [chemical binding]; other site 246196004983 metal binding site [ion binding]; metal-binding site 246196004984 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 246196004985 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 246196004986 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 246196004987 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196004988 hypothetical protein; Provisional; Region: PRK07236 246196004989 amino acid transporter; Region: 2A0306; TIGR00909 246196004990 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 246196004991 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 246196004992 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246196004993 Di-iron ligands [ion binding]; other site 246196004994 Rubredoxin [Energy production and conversion]; Region: COG1773 246196004995 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 246196004996 iron binding site [ion binding]; other site 246196004997 Rubredoxin [Energy production and conversion]; Region: COG1773 246196004998 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 246196004999 iron binding site [ion binding]; other site 246196005000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005002 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 246196005003 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 246196005004 homotetramer interface [polypeptide binding]; other site 246196005005 ligand binding site [chemical binding]; other site 246196005006 catalytic site [active] 246196005007 NAD binding site [chemical binding]; other site 246196005008 Predicted membrane protein [Function unknown]; Region: COG2323 246196005009 Predicted membrane protein [Function unknown]; Region: COG2860 246196005010 UPF0126 domain; Region: UPF0126; pfam03458 246196005011 UPF0126 domain; Region: UPF0126; pfam03458 246196005012 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 246196005013 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 246196005014 4Fe-4S binding domain; Region: Fer4_6; pfam12837 246196005015 potential frameshift: common BLAST hit: gi|108802181|ref|YP_642378.1| formate dehydrogenase 246196005016 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196005017 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 246196005018 molybdopterin cofactor binding site; other site 246196005019 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196005020 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196005021 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196005022 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196005023 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 246196005024 G1 box; other site 246196005025 putative GEF interaction site [polypeptide binding]; other site 246196005026 GTP/Mg2+ binding site [chemical binding]; other site 246196005027 Switch I region; other site 246196005028 G2 box; other site 246196005029 G3 box; other site 246196005030 Switch II region; other site 246196005031 G4 box; other site 246196005032 G5 box; other site 246196005033 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 246196005034 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 246196005035 selenocysteine synthase; Provisional; Region: PRK04311 246196005036 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 246196005037 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196005038 selenophosphate synthetase; Provisional; Region: PRK00943 246196005039 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 246196005040 dimerization interface [polypeptide binding]; other site 246196005041 putative ATP binding site [chemical binding]; other site 246196005042 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 246196005043 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246196005044 Thioredoxin; Region: Thioredoxin_4; cl17273 246196005045 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 246196005046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005047 ATP binding site [chemical binding]; other site 246196005048 Walker B motif; other site 246196005049 arginine finger; other site 246196005050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196005051 TPR motif; other site 246196005052 binding surface 246196005053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196005054 TPR motif; other site 246196005055 binding surface 246196005056 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 246196005057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246196005058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196005059 salt bridge; other site 246196005060 non-specific DNA binding site [nucleotide binding]; other site 246196005061 sequence-specific DNA binding site [nucleotide binding]; other site 246196005062 Integrase core domain; Region: rve; pfam00665 246196005063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246196005064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005065 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196005066 Walker A motif; other site 246196005067 ATP binding site [chemical binding]; other site 246196005068 Walker B motif; other site 246196005069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 246196005070 Integrase core domain; Region: rve; pfam00665 246196005071 Integrase core domain; Region: rve_3; pfam13683 246196005072 Integrase core domain; Region: rve_3; pfam13683 246196005073 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196005074 putative transposase OrfB; Reviewed; Region: PHA02517 246196005075 HTH-like domain; Region: HTH_21; pfam13276 246196005076 Integrase core domain; Region: rve; pfam00665 246196005077 Integrase core domain; Region: rve_3; pfam13683 246196005078 Transposase; Region: HTH_Tnp_1; pfam01527 246196005079 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246196005080 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246196005081 dimer interface [polypeptide binding]; other site 246196005082 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 246196005083 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 246196005084 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 246196005085 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 246196005086 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 246196005087 TMP-binding site; other site 246196005088 ATP-binding site [chemical binding]; other site 246196005089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196005090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196005091 active site 246196005092 phosphorylation site [posttranslational modification] 246196005093 intermolecular recognition site; other site 246196005094 dimerization interface [polypeptide binding]; other site 246196005095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196005096 DNA binding site [nucleotide binding] 246196005097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196005098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196005099 dimerization interface [polypeptide binding]; other site 246196005100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196005101 dimer interface [polypeptide binding]; other site 246196005102 phosphorylation site [posttranslational modification] 246196005103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196005104 ATP binding site [chemical binding]; other site 246196005105 Mg2+ binding site [ion binding]; other site 246196005106 G-X-G motif; other site 246196005107 lipoprotein LpqB; Provisional; Region: PRK13616 246196005108 Sporulation and spore germination; Region: Germane; pfam10646 246196005109 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 246196005110 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 246196005111 30S subunit binding site; other site 246196005112 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 246196005113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246196005114 ATP binding site [chemical binding]; other site 246196005115 putative Mg++ binding site [ion binding]; other site 246196005116 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 246196005117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 246196005118 nucleotide binding region [chemical binding]; other site 246196005119 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196005120 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196005121 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246196005122 BCCT family transporter; Region: BCCT; pfam02028 246196005123 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 246196005124 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196005125 FAD binding pocket [chemical binding]; other site 246196005126 FAD binding motif [chemical binding]; other site 246196005127 phosphate binding motif [ion binding]; other site 246196005128 beta-alpha-beta structure motif; other site 246196005129 NAD binding pocket [chemical binding]; other site 246196005130 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005131 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 246196005132 catalytic loop [active] 246196005133 iron binding site [ion binding]; other site 246196005134 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 246196005135 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246196005136 putative di-iron ligands [ion binding]; other site 246196005137 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196005138 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196005139 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196005140 Predicted GTPases [General function prediction only]; Region: COG1162 246196005141 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 246196005142 GTPase/Zn-binding domain interface [polypeptide binding]; other site 246196005143 GTP/Mg2+ binding site [chemical binding]; other site 246196005144 G4 box; other site 246196005145 G5 box; other site 246196005146 G1 box; other site 246196005147 Switch I region; other site 246196005148 G2 box; other site 246196005149 G3 box; other site 246196005150 Switch II region; other site 246196005151 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 246196005152 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 246196005153 hinge; other site 246196005154 active site 246196005155 Uncharacterized conserved protein [Function unknown]; Region: COG2135 246196005156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196005157 S-adenosylmethionine binding site [chemical binding]; other site 246196005158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196005159 short chain dehydrogenase; Provisional; Region: PRK08278 246196005160 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 246196005161 NAD(P) binding site [chemical binding]; other site 246196005162 homodimer interface [polypeptide binding]; other site 246196005163 active site 246196005164 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 246196005165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196005166 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196005167 dimerization interface [polypeptide binding]; other site 246196005168 substrate binding pocket [chemical binding]; other site 246196005169 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 246196005170 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196005171 dimer interface [polypeptide binding]; other site 246196005172 active site 246196005173 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 246196005174 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246196005175 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 246196005176 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 246196005177 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 246196005178 AAA ATPase domain; Region: AAA_16; pfam13191 246196005179 AAA domain; Region: AAA_22; pfam13401 246196005180 Walker A motif; other site 246196005181 ATP binding site [chemical binding]; other site 246196005182 Walker B motif; other site 246196005183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196005184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196005185 DNA binding residues [nucleotide binding] 246196005186 dimerization interface [polypeptide binding]; other site 246196005187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196005188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196005189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196005190 dimerization interface [polypeptide binding]; other site 246196005191 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005192 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196005193 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005194 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196005195 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005196 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005197 active site 246196005198 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196005199 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196005200 active site 246196005201 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 246196005202 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005203 catalytic loop [active] 246196005204 iron binding site [ion binding]; other site 246196005205 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 246196005206 FAD binding pocket [chemical binding]; other site 246196005207 FAD binding motif [chemical binding]; other site 246196005208 phosphate binding motif [ion binding]; other site 246196005209 beta-alpha-beta structure motif; other site 246196005210 NAD binding pocket [chemical binding]; other site 246196005211 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196005212 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196005213 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 246196005214 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 246196005215 putative NAD(P) binding site [chemical binding]; other site 246196005216 active site 246196005217 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 246196005218 inter-subunit interface; other site 246196005219 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 246196005220 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196005221 iron-sulfur cluster [ion binding]; other site 246196005222 [2Fe-2S] cluster binding site [ion binding]; other site 246196005223 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 246196005224 putative alpha subunit interface [polypeptide binding]; other site 246196005225 putative active site [active] 246196005226 putative substrate binding site [chemical binding]; other site 246196005227 Fe binding site [ion binding]; other site 246196005228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196005229 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196005230 dimerization interface [polypeptide binding]; other site 246196005231 substrate binding pocket [chemical binding]; other site 246196005232 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 246196005233 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 246196005234 active site 246196005235 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 246196005236 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 246196005237 active site 246196005238 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 246196005239 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 246196005240 putative deacylase active site [active] 246196005241 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 246196005242 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196005243 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196005244 DNA binding residues [nucleotide binding] 246196005245 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 246196005246 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196005247 carboxyltransferase (CT) interaction site; other site 246196005248 biotinylation site [posttranslational modification]; other site 246196005249 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 246196005250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 246196005251 Histidine kinase; Region: HisKA_2; pfam07568 246196005252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196005253 ATP binding site [chemical binding]; other site 246196005254 Mg2+ binding site [ion binding]; other site 246196005255 G-X-G motif; other site 246196005256 Transcription factor WhiB; Region: Whib; pfam02467 246196005257 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 246196005258 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246196005259 SEC-C motif; Region: SEC-C; pfam02810 246196005260 hypothetical protein; Provisional; Region: PRK04233 246196005261 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 246196005262 Dehydroquinase class II; Region: DHquinase_II; pfam01220 246196005263 active site 246196005264 trimer interface [polypeptide binding]; other site 246196005265 dimer interface [polypeptide binding]; other site 246196005266 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 246196005267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196005268 Coenzyme A binding pocket [chemical binding]; other site 246196005269 isochorismate synthase DhbC; Validated; Region: PRK06923 246196005270 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246196005271 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196005272 catalytic core [active] 246196005273 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246196005274 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196005275 P-loop; other site 246196005276 Magnesium ion binding site [ion binding]; other site 246196005277 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 246196005278 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196005279 Magnesium ion binding site [ion binding]; other site 246196005280 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246196005281 active site 246196005282 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246196005283 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246196005284 ATP binding site [chemical binding]; other site 246196005285 Mg++ binding site [ion binding]; other site 246196005286 motif III; other site 246196005287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196005288 nucleotide binding region [chemical binding]; other site 246196005289 ATP-binding site [chemical binding]; other site 246196005290 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246196005291 dinuclear metal binding motif [ion binding]; other site 246196005292 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 246196005293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005295 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 246196005296 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 246196005297 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 246196005298 ATP binding site [chemical binding]; other site 246196005299 substrate interface [chemical binding]; other site 246196005300 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196005301 active site residue [active] 246196005302 TIGR02569 family protein; Region: TIGR02569_actnb 246196005303 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246196005304 active site 246196005305 DNA binding site [nucleotide binding] 246196005306 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196005307 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196005308 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196005309 catalytic site [active] 246196005310 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 246196005311 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246196005312 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 246196005313 Part of AAA domain; Region: AAA_19; pfam13245 246196005314 Family description; Region: UvrD_C_2; pfam13538 246196005315 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246196005316 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 246196005317 Predicted membrane protein [Function unknown]; Region: COG4270 246196005318 Ion channel; Region: Ion_trans_2; pfam07885 246196005319 TrkA-N domain; Region: TrkA_N; pfam02254 246196005320 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 246196005321 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 246196005322 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 246196005323 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 246196005324 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 246196005325 putative NADH binding site [chemical binding]; other site 246196005326 putative active site [active] 246196005327 nudix motif; other site 246196005328 putative metal binding site [ion binding]; other site 246196005329 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 246196005330 catalytic residues [active] 246196005331 CsbD-like; Region: CsbD; pfam05532 246196005332 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 246196005333 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 246196005334 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 246196005335 Family description; Region: UvrD_C_2; pfam13538 246196005336 HRDC domain; Region: HRDC; pfam00570 246196005337 Transcription factor WhiB; Region: Whib; pfam02467 246196005338 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 246196005339 ABC1 family; Region: ABC1; pfam03109 246196005340 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 246196005341 active site 246196005342 ATP binding site [chemical binding]; other site 246196005343 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 246196005344 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 246196005345 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 246196005346 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 246196005347 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246196005348 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246196005349 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 246196005350 hypothetical protein; Validated; Region: PRK00068 246196005351 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196005352 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 246196005353 DNA binding site [nucleotide binding] 246196005354 Bacterial transcriptional activator domain; Region: BTAD; smart01043 246196005355 AAA ATPase domain; Region: AAA_16; pfam13191 246196005356 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196005357 FAD binding domain; Region: FAD_binding_4; pfam01565 246196005358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005360 short chain dehydrogenase; Validated; Region: PRK08264 246196005361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196005362 NAD(P) binding site [chemical binding]; other site 246196005363 active site 246196005364 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 246196005365 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196005366 DNA binding residues [nucleotide binding] 246196005367 putative dimer interface [polypeptide binding]; other site 246196005368 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 246196005369 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 246196005370 DNA-binding interface [nucleotide binding]; DNA binding site 246196005371 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 246196005372 dimerization interface [polypeptide binding]; other site 246196005373 putative path to active site cavity [active] 246196005374 diiron center [ion binding]; other site 246196005375 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 246196005376 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005377 catalytic loop [active] 246196005378 iron binding site [ion binding]; other site 246196005379 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 246196005380 FAD binding pocket [chemical binding]; other site 246196005381 conserved FAD binding motif [chemical binding]; other site 246196005382 phosphate binding motif [ion binding]; other site 246196005383 beta-alpha-beta structure motif; other site 246196005384 NAD binding pocket [chemical binding]; other site 246196005385 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 246196005386 dimerization interface [polypeptide binding]; other site 246196005387 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 246196005388 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196005389 Domain of unknown function DUF59; Region: DUF59; pfam01883 246196005390 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196005391 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 246196005392 NAD binding site [chemical binding]; other site 246196005393 substrate binding site [chemical binding]; other site 246196005394 catalytic Zn binding site [ion binding]; other site 246196005395 structural Zn binding site [ion binding]; other site 246196005396 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 246196005397 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246196005398 ring oligomerisation interface [polypeptide binding]; other site 246196005399 ATP/Mg binding site [chemical binding]; other site 246196005400 stacking interactions; other site 246196005401 hinge regions; other site 246196005402 Uncharacterized conserved protein [Function unknown]; Region: COG1359 246196005403 hypothetical protein; Provisional; Region: PRK07588 246196005404 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196005405 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196005406 acyl-CoA synthetase; Validated; Region: PRK08162 246196005407 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 246196005408 acyl-activating enzyme (AAE) consensus motif; other site 246196005409 putative active site [active] 246196005410 AMP binding site [chemical binding]; other site 246196005411 putative CoA binding site [chemical binding]; other site 246196005412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005413 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196005414 putative substrate translocation pore; other site 246196005415 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 246196005416 transcriptional activator TtdR; Provisional; Region: PRK09801 246196005417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196005418 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 246196005419 putative effector binding pocket; other site 246196005420 putative dimerization interface [polypeptide binding]; other site 246196005421 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 246196005422 tartrate dehydrogenase; Region: TTC; TIGR02089 246196005423 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 246196005424 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196005425 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196005426 FMN-binding pocket [chemical binding]; other site 246196005427 flavin binding motif; other site 246196005428 phosphate binding motif [ion binding]; other site 246196005429 beta-alpha-beta structure motif; other site 246196005430 NAD binding pocket [chemical binding]; other site 246196005431 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005432 catalytic loop [active] 246196005433 iron binding site [ion binding]; other site 246196005434 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 246196005435 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005436 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005437 active site 246196005438 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005439 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196005440 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196005441 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196005442 active site 2 [active] 246196005443 active site 1 [active] 246196005444 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196005445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005446 DNA-binding site [nucleotide binding]; DNA binding site 246196005447 FCD domain; Region: FCD; pfam07729 246196005448 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196005449 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196005450 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196005451 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196005452 active site 246196005453 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196005454 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196005455 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196005456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 246196005457 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196005458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196005459 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196005460 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196005461 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 246196005462 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 246196005463 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196005464 active site 246196005465 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196005466 active site 246196005467 metal binding site [ion binding]; metal-binding site 246196005468 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196005469 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196005470 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196005471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005472 DNA-binding site [nucleotide binding]; DNA binding site 246196005473 FCD domain; Region: FCD; pfam07729 246196005474 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 246196005475 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196005476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196005477 DNA binding site [nucleotide binding] 246196005478 domain linker motif; other site 246196005479 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196005480 ligand binding site [chemical binding]; other site 246196005481 dimerization interface [polypeptide binding]; other site 246196005482 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 246196005483 histidinol dehydrogenase; Region: hisD; TIGR00069 246196005484 NAD binding site [chemical binding]; other site 246196005485 dimerization interface [polypeptide binding]; other site 246196005486 product binding site; other site 246196005487 substrate binding site [chemical binding]; other site 246196005488 zinc binding site [ion binding]; other site 246196005489 catalytic residues [active] 246196005490 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06077 246196005491 classical (c) SDRs; Region: SDR_c; cd05233 246196005492 NAD(P) binding site [chemical binding]; other site 246196005493 active site 246196005494 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 246196005495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196005496 Walker A/P-loop; other site 246196005497 ATP binding site [chemical binding]; other site 246196005498 Q-loop/lid; other site 246196005499 ABC transporter signature motif; other site 246196005500 Walker B; other site 246196005501 D-loop; other site 246196005502 H-loop/switch region; other site 246196005503 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246196005504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 246196005505 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 246196005506 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246196005507 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 246196005508 DNA binding residues [nucleotide binding] 246196005509 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196005510 TOBE domain; Region: TOBE; cl01440 246196005511 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196005512 classical (c) SDRs; Region: SDR_c; cd05233 246196005513 NAD(P) binding site [chemical binding]; other site 246196005514 active site 246196005515 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196005516 Cytochrome P450; Region: p450; cl12078 246196005517 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196005518 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196005519 GntP family permease; Region: GntP_permease; pfam02447 246196005520 fructuronate transporter; Provisional; Region: PRK10034; cl15264 246196005521 fructuronate transporter; Provisional; Region: PRK10034; cl15264 246196005522 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005523 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196005524 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 246196005525 active site 246196005526 catalytic residues [active] 246196005527 metal binding site [ion binding]; metal-binding site 246196005528 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196005529 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196005530 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196005531 short chain dehydrogenase; Provisional; Region: PRK06180 246196005532 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196005533 NADP binding site [chemical binding]; other site 246196005534 active site 246196005535 steroid binding site; other site 246196005536 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196005537 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196005538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005539 putative substrate translocation pore; other site 246196005540 short chain dehydrogenase; Provisional; Region: PRK09134 246196005541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196005542 NAD(P) binding site [chemical binding]; other site 246196005543 active site 246196005544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005546 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 246196005547 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196005548 catalytic residue [active] 246196005549 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 246196005550 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196005551 NAD(P) binding site [chemical binding]; other site 246196005552 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 246196005553 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 246196005554 catalytic Zn binding site [ion binding]; other site 246196005555 NAD binding site [chemical binding]; other site 246196005556 structural Zn binding site [ion binding]; other site 246196005557 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196005558 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196005559 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 246196005560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196005561 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196005562 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196005563 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196005564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196005565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196005566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196005567 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196005568 putative active site [active] 246196005569 putative substrate binding site [chemical binding]; other site 246196005570 ATP binding site [chemical binding]; other site 246196005571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005573 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196005574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005575 putative substrate translocation pore; other site 246196005576 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196005577 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196005578 active site 246196005579 non-prolyl cis peptide bond; other site 246196005580 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 246196005581 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196005582 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 246196005583 putative NAD(P) binding site [chemical binding]; other site 246196005584 catalytic Zn binding site [ion binding]; other site 246196005585 structural Zn binding site [ion binding]; other site 246196005586 potential frameshift: common BLAST hit: gi|118469769|ref|YP_886409.1| enoyl-CoA hydratase 246196005587 enoyl-CoA hydratase; Provisional; Region: PRK06190 246196005588 enoyl-CoA hydratase; Provisional; Region: PRK06190 246196005589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196005590 substrate binding site [chemical binding]; other site 246196005591 oxyanion hole (OAH) forming residues; other site 246196005592 trimer interface [polypeptide binding]; other site 246196005593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005595 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 246196005596 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196005597 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 246196005598 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196005599 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 246196005600 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 246196005601 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196005602 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 246196005603 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 246196005604 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 246196005605 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 246196005606 4Fe-4S binding domain; Region: Fer4; pfam00037 246196005607 4Fe-4S binding domain; Region: Fer4; pfam00037 246196005608 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 246196005609 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 246196005610 NADH dehydrogenase subunit G; Validated; Region: PRK07860 246196005611 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005612 catalytic loop [active] 246196005613 iron binding site [ion binding]; other site 246196005614 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 246196005615 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196005616 molybdopterin cofactor binding site; other site 246196005617 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 246196005618 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 246196005619 SLBB domain; Region: SLBB; pfam10531 246196005620 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 246196005621 NADH dehydrogenase subunit E; Validated; Region: PRK07539 246196005622 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 246196005623 putative dimer interface [polypeptide binding]; other site 246196005624 [2Fe-2S] cluster binding site [ion binding]; other site 246196005625 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 246196005626 NADH dehydrogenase subunit D; Validated; Region: PRK06075 246196005627 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 246196005628 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 246196005629 NADH dehydrogenase subunit B; Validated; Region: PRK06411 246196005630 NADH dehydrogenase subunit A; Validated; Region: PRK07928 246196005631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196005632 active site 246196005633 phosphorylation site [posttranslational modification] 246196005634 intermolecular recognition site; other site 246196005635 dimerization interface [polypeptide binding]; other site 246196005636 YceI-like domain; Region: YceI; pfam04264 246196005637 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196005638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196005639 S-adenosylmethionine binding site [chemical binding]; other site 246196005640 Phosphotransferase enzyme family; Region: APH; pfam01636 246196005641 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196005642 putative active site [active] 246196005643 putative substrate binding site [chemical binding]; other site 246196005644 ATP binding site [chemical binding]; other site 246196005645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005646 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196005647 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196005648 active site 246196005649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005651 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 246196005652 active site 246196005653 catalytic residues [active] 246196005654 metal binding site [ion binding]; metal-binding site 246196005655 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005656 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196005657 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196005658 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196005659 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 246196005660 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 246196005661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005662 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005663 active site 246196005664 Putative esterase; Region: Esterase; pfam00756 246196005665 S-formylglutathione hydrolase; Region: PLN02442 246196005666 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 246196005667 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 246196005668 NADP binding site [chemical binding]; other site 246196005669 dimer interface [polypeptide binding]; other site 246196005670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005672 active site 246196005673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005674 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005675 active site 246196005676 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 246196005677 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 246196005678 active site 246196005679 ferredoxin-NADP+ reductase; Region: PLN02852 246196005680 peptide chain release factor 2; Validated; Region: prfB; PRK00578 246196005681 This domain is found in peptide chain release factors; Region: PCRF; smart00937 246196005682 RF-1 domain; Region: RF-1; pfam00472 246196005683 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246196005684 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246196005685 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 246196005686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196005687 Walker A/P-loop; other site 246196005688 ATP binding site [chemical binding]; other site 246196005689 Q-loop/lid; other site 246196005690 ABC transporter signature motif; other site 246196005691 Walker B; other site 246196005692 D-loop; other site 246196005693 H-loop/switch region; other site 246196005694 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 246196005695 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 246196005696 FtsX-like permease family; Region: FtsX; pfam02687 246196005697 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 246196005698 SmpB-tmRNA interface; other site 246196005699 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 246196005700 homodimer interface [polypeptide binding]; other site 246196005701 homotetramer interface [polypeptide binding]; other site 246196005702 active site pocket [active] 246196005703 cleavage site 246196005704 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 246196005705 Cutinase; Region: Cutinase; pfam01083 246196005706 hypothetical protein; Provisional; Region: PRK10621 246196005707 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196005708 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 246196005709 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 246196005710 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196005711 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196005712 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196005713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196005714 substrate binding pocket [chemical binding]; other site 246196005715 membrane-bound complex binding site; other site 246196005716 hinge residues; other site 246196005717 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 246196005718 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 246196005719 putative metal binding site [ion binding]; other site 246196005720 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196005721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196005722 dimer interface [polypeptide binding]; other site 246196005723 conserved gate region; other site 246196005724 ABC-ATPase subunit interface; other site 246196005725 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196005726 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196005727 Walker A/P-loop; other site 246196005728 ATP binding site [chemical binding]; other site 246196005729 Q-loop/lid; other site 246196005730 ABC transporter signature motif; other site 246196005731 Walker B; other site 246196005732 D-loop; other site 246196005733 H-loop/switch region; other site 246196005734 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 246196005735 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196005736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005737 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 246196005738 DNA-binding site [nucleotide binding]; DNA binding site 246196005739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196005740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196005741 homodimer interface [polypeptide binding]; other site 246196005742 catalytic residue [active] 246196005743 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 246196005744 nucleotide binding site [chemical binding]; other site 246196005745 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196005746 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 246196005747 DNA-binding interface [nucleotide binding]; DNA binding site 246196005748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005749 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 246196005750 glycoprotein BALF4; Provisional; Region: PHA03231 246196005751 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 246196005752 chorismate mutase; Provisional; Region: PRK09269 246196005753 Chorismate mutase type II; Region: CM_2; cl00693 246196005754 Cupin domain; Region: Cupin_2; cl17218 246196005755 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 246196005756 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 246196005757 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 246196005758 active site turn [active] 246196005759 phosphorylation site [posttranslational modification] 246196005760 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 246196005761 HPr interaction site; other site 246196005762 glycerol kinase (GK) interaction site [polypeptide binding]; other site 246196005763 active site 246196005764 phosphorylation site [posttranslational modification] 246196005765 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 246196005766 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 246196005767 active site 246196005768 trimer interface [polypeptide binding]; other site 246196005769 allosteric site; other site 246196005770 active site lid [active] 246196005771 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 246196005772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196005773 active site 246196005774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005775 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196005776 Walker A motif; other site 246196005777 ATP binding site [chemical binding]; other site 246196005778 Walker B motif; other site 246196005779 arginine finger; other site 246196005780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196005781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196005782 DNA binding residues [nucleotide binding] 246196005783 dimerization interface [polypeptide binding]; other site 246196005784 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 246196005785 active site 246196005786 active pocket/dimerization site; other site 246196005787 phosphorylation site [posttranslational modification] 246196005788 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 246196005789 dimerization domain swap beta strand [polypeptide binding]; other site 246196005790 regulatory protein interface [polypeptide binding]; other site 246196005791 active site 246196005792 regulatory phosphorylation site [posttranslational modification]; other site 246196005793 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 246196005794 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 246196005795 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 246196005796 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246196005797 DAK2 domain; Region: Dak2; cl03685 246196005798 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 246196005799 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 246196005800 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 246196005801 amphipathic channel; other site 246196005802 Asn-Pro-Ala signature motifs; other site 246196005803 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196005804 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196005805 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196005806 Protein of unknown function, DUF488; Region: DUF488; cl01246 246196005807 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 246196005808 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 246196005809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005811 active site 246196005812 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 246196005813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196005814 acyl-activating enzyme (AAE) consensus motif; other site 246196005815 AMP binding site [chemical binding]; other site 246196005816 active site 246196005817 CoA binding site [chemical binding]; other site 246196005818 acyl carrier protein; Validated; Region: PRK05883 246196005819 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 246196005820 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 246196005821 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 246196005822 camphor resistance protein CrcB; Provisional; Region: PRK14228 246196005823 camphor resistance protein CrcB; Provisional; Region: PRK14216 246196005824 phosphoglucomutase; Validated; Region: PRK07564 246196005825 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 246196005826 active site 246196005827 substrate binding site [chemical binding]; other site 246196005828 metal binding site [ion binding]; metal-binding site 246196005829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005830 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196005831 putative substrate translocation pore; other site 246196005832 Fic/DOC family; Region: Fic; pfam02661 246196005833 Fic family protein [Function unknown]; Region: COG3177 246196005834 HTH DNA binding domain; Region: HTH_13; pfam11972 246196005835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196005836 sequence-specific DNA binding site [nucleotide binding]; other site 246196005837 salt bridge; other site 246196005838 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 246196005839 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 246196005840 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196005841 active site 246196005842 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 246196005843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246196005844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005845 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196005846 Walker A motif; other site 246196005847 ATP binding site [chemical binding]; other site 246196005848 Walker B motif; other site 246196005849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246196005850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196005851 salt bridge; other site 246196005852 non-specific DNA binding site [nucleotide binding]; other site 246196005853 sequence-specific DNA binding site [nucleotide binding]; other site 246196005854 Integrase core domain; Region: rve; pfam00665 246196005855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005857 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196005858 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 246196005859 active site 246196005860 dimer interface [polypeptide binding]; other site 246196005861 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196005862 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 246196005863 NADP binding site [chemical binding]; other site 246196005864 dimer interface [polypeptide binding]; other site 246196005865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196005866 NmrA-like family; Region: NmrA; pfam05368 246196005867 NAD(P) binding site [chemical binding]; other site 246196005868 active site 246196005869 TIGR04222 domain; Region: near_uncomplex 246196005870 hypothetical protein; Provisional; Region: PRK05409 246196005871 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196005872 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196005873 AMP binding site [chemical binding]; other site 246196005874 active site 246196005875 CoA binding site [chemical binding]; other site 246196005876 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196005877 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246196005878 putative NAD(P) binding site [chemical binding]; other site 246196005879 active site 246196005880 putative substrate binding site [chemical binding]; other site 246196005881 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196005882 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 246196005883 NAD(P) binding site [chemical binding]; other site 246196005884 catalytic residues [active] 246196005885 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196005886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005887 DNA-binding site [nucleotide binding]; DNA binding site 246196005888 FCD domain; Region: FCD; pfam07729 246196005889 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196005890 TPP-binding site [chemical binding]; other site 246196005891 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 246196005892 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246196005893 PYR/PP interface [polypeptide binding]; other site 246196005894 dimer interface [polypeptide binding]; other site 246196005895 TPP binding site [chemical binding]; other site 246196005896 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196005897 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196005898 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196005899 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246196005900 active site 246196005901 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196005902 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196005903 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196005904 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005905 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196005906 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 246196005907 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196005908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005909 DNA-binding site [nucleotide binding]; DNA binding site 246196005910 FCD domain; Region: FCD; pfam07729 246196005911 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 246196005912 Part of AAA domain; Region: AAA_19; pfam13245 246196005913 Family description; Region: UvrD_C_2; pfam13538 246196005914 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 246196005915 dimer interface [polypeptide binding]; other site 246196005916 putative active site [active] 246196005917 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196005918 active site 246196005919 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196005920 non-prolyl cis peptide bond; other site 246196005921 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196005922 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196005923 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196005924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005928 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 246196005929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005931 Fic/DOC family; Region: Fic; cl00960 246196005932 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246196005933 metal binding triad; other site 246196005934 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 246196005935 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196005936 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 246196005937 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 246196005938 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 246196005939 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 246196005940 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 246196005941 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 246196005942 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 246196005943 allophanate hydrolase; Provisional; Region: PRK08186 246196005944 Amidase; Region: Amidase; cl11426 246196005945 EamA-like transporter family; Region: EamA; pfam00892 246196005946 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 246196005947 EamA-like transporter family; Region: EamA; pfam00892 246196005948 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 246196005949 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196005950 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196005951 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 246196005952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005953 active site 246196005954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196005955 PAS domain; Region: PAS_9; pfam13426 246196005956 putative active site [active] 246196005957 heme pocket [chemical binding]; other site 246196005958 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196005959 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 246196005960 DNA binding residues [nucleotide binding] 246196005961 dimer interface [polypeptide binding]; other site 246196005962 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 246196005963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005967 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196005968 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246196005969 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246196005970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246196005971 metal binding site [ion binding]; metal-binding site 246196005972 active site 246196005973 I-site; other site 246196005974 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 246196005975 hypothetical protein; Provisional; Region: PRK07877 246196005976 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 246196005977 ATP binding site [chemical binding]; other site 246196005978 substrate interface [chemical binding]; other site 246196005979 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 246196005980 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 246196005981 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 246196005982 putative active site [active] 246196005983 putative substrate binding site [chemical binding]; other site 246196005984 putative cosubstrate binding site; other site 246196005985 catalytic site [active] 246196005986 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 246196005987 putative active site [active] 246196005988 putative catalytic site [active] 246196005989 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 246196005990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196005991 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196005992 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246196005993 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196005994 classical (c) SDRs; Region: SDR_c; cd05233 246196005995 NAD(P) binding site [chemical binding]; other site 246196005996 active site 246196005997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005998 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005999 active site 246196006000 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196006001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006002 NAD(P) binding site [chemical binding]; other site 246196006003 active site 246196006004 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 246196006005 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196006006 dimer interface [polypeptide binding]; other site 246196006007 active site 246196006008 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196006009 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196006010 active site 246196006011 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196006012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006013 DNA-binding site [nucleotide binding]; DNA binding site 246196006014 FCD domain; Region: FCD; pfam07729 246196006015 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196006016 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196006017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196006018 sequence-specific DNA binding site [nucleotide binding]; other site 246196006019 salt bridge; other site 246196006020 short chain dehydrogenase; Provisional; Region: PRK05854 246196006021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006022 NAD(P) binding site [chemical binding]; other site 246196006023 active site 246196006024 O-methyltransferase; Region: Methyltransf_2; pfam00891 246196006025 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196006026 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196006027 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006028 acyl-activating enzyme (AAE) consensus motif; other site 246196006029 AMP binding site [chemical binding]; other site 246196006030 active site 246196006031 CoA binding site [chemical binding]; other site 246196006032 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196006033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006034 acyl-activating enzyme (AAE) consensus motif; other site 246196006035 AMP binding site [chemical binding]; other site 246196006036 active site 246196006037 CoA binding site [chemical binding]; other site 246196006038 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196006039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006040 acyl-activating enzyme (AAE) consensus motif; other site 246196006041 AMP binding site [chemical binding]; other site 246196006042 active site 246196006043 CoA binding site [chemical binding]; other site 246196006044 enoyl-CoA hydratase; Provisional; Region: PRK08290 246196006045 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006046 substrate binding site [chemical binding]; other site 246196006047 oxyanion hole (OAH) forming residues; other site 246196006048 trimer interface [polypeptide binding]; other site 246196006049 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196006050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006051 substrate binding site [chemical binding]; other site 246196006052 oxyanion hole (OAH) forming residues; other site 246196006053 trimer interface [polypeptide binding]; other site 246196006054 enoyl-CoA hydratase; Provisional; Region: PRK06688 246196006055 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006056 substrate binding site [chemical binding]; other site 246196006057 oxyanion hole (OAH) forming residues; other site 246196006058 trimer interface [polypeptide binding]; other site 246196006059 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006060 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 246196006061 substrate binding site [chemical binding]; other site 246196006062 oxyanion hole (OAH) forming residues; other site 246196006063 trimer interface [polypeptide binding]; other site 246196006064 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196006065 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 246196006066 dimer interface [polypeptide binding]; other site 246196006067 active site 246196006068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006069 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196006070 enoyl-CoA hydratase; Provisional; Region: PRK08252 246196006071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006072 substrate binding site [chemical binding]; other site 246196006073 oxyanion hole (OAH) forming residues; other site 246196006074 trimer interface [polypeptide binding]; other site 246196006075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006076 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246196006077 NAD(P) binding site [chemical binding]; other site 246196006078 active site 246196006079 enoyl-CoA hydratase; Provisional; Region: PRK06210 246196006080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006081 substrate binding site [chemical binding]; other site 246196006082 oxyanion hole (OAH) forming residues; other site 246196006083 trimer interface [polypeptide binding]; other site 246196006084 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196006085 acyl-CoA synthetase; Validated; Region: PRK07798 246196006086 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006087 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 246196006088 acyl-activating enzyme (AAE) consensus motif; other site 246196006089 acyl-activating enzyme (AAE) consensus motif; other site 246196006090 putative AMP binding site [chemical binding]; other site 246196006091 putative active site [active] 246196006092 putative CoA binding site [chemical binding]; other site 246196006093 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 246196006094 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196006095 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196006096 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196006097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196006098 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196006099 active site 246196006100 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196006101 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 246196006102 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196006103 active site 246196006104 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246196006105 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196006106 molybdopterin cofactor binding site; other site 246196006107 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 246196006108 molybdopterin cofactor binding site; other site 246196006109 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 246196006110 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196006111 NAD binding site [chemical binding]; other site 246196006112 catalytic residues [active] 246196006113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006115 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196006116 Cytochrome P450; Region: p450; cl12078 246196006117 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 246196006118 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196006119 NAD(P) binding site [chemical binding]; other site 246196006120 catalytic residues [active] 246196006121 acyl-CoA synthetase; Validated; Region: PRK07798 246196006122 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006123 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 246196006124 acyl-activating enzyme (AAE) consensus motif; other site 246196006125 acyl-activating enzyme (AAE) consensus motif; other site 246196006126 putative AMP binding site [chemical binding]; other site 246196006127 putative active site [active] 246196006128 putative CoA binding site [chemical binding]; other site 246196006129 Isochorismatase family; Region: Isochorismatase; pfam00857 246196006130 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246196006131 catalytic triad [active] 246196006132 conserved cis-peptide bond; other site 246196006133 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196006134 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196006135 [2Fe-2S] cluster binding site [ion binding]; other site 246196006136 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196006137 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196006138 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 246196006139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006140 NAD(P) binding site [chemical binding]; other site 246196006141 active site 246196006142 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 246196006143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196006144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196006145 PAS domain; Region: PAS_9; pfam13426 246196006146 putative active site [active] 246196006147 heme pocket [chemical binding]; other site 246196006148 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196006149 GAF domain; Region: GAF_3; pfam13492 246196006150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196006151 Histidine kinase; Region: HisKA_3; pfam07730 246196006152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196006153 Response regulator receiver domain; Region: Response_reg; pfam00072 246196006154 active site 246196006155 phosphorylation site [posttranslational modification] 246196006156 intermolecular recognition site; other site 246196006157 dimerization interface [polypeptide binding]; other site 246196006158 hypothetical protein; Provisional; Region: PRK06834 246196006159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196006160 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196006161 Cupin; Region: Cupin_1; smart00835 246196006162 Cupin; Region: Cupin_1; smart00835 246196006163 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196006164 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196006165 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196006166 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196006167 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196006168 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196006169 Cytochrome P450; Region: p450; cl12078 246196006170 Protein of unknown function (DUF466); Region: DUF466; pfam04328 246196006171 carbon starvation protein A; Provisional; Region: PRK15015 246196006172 Carbon starvation protein CstA; Region: CstA; pfam02554 246196006173 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 246196006174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196006175 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196006176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196006177 Uncharacterized conserved protein [Function unknown]; Region: COG2427 246196006178 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 246196006179 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 246196006180 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 246196006181 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 246196006182 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 246196006183 nickel binding site [ion binding]; other site 246196006184 NifU-like domain; Region: NifU; cl00484 246196006185 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196006186 iron-sulfur cluster [ion binding]; other site 246196006187 [2Fe-2S] cluster binding site [ion binding]; other site 246196006188 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196006189 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 246196006190 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 246196006191 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 246196006192 Acylphosphatase; Region: Acylphosphatase; pfam00708 246196006193 HypF finger; Region: zf-HYPF; pfam07503 246196006194 HypF finger; Region: zf-HYPF; pfam07503 246196006195 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 246196006196 HupF/HypC family; Region: HupF_HypC; pfam01455 246196006197 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 246196006198 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 246196006199 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 246196006200 dimerization interface [polypeptide binding]; other site 246196006201 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 246196006202 ATP binding site [chemical binding]; other site 246196006203 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 246196006204 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 246196006205 active site 246196006206 DNA binding site [nucleotide binding] 246196006207 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 246196006208 DNA binding site [nucleotide binding] 246196006209 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 246196006210 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 246196006211 Moco binding site; other site 246196006212 metal coordination site [ion binding]; other site 246196006213 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196006214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006215 NAD(P) binding site [chemical binding]; other site 246196006216 active site 246196006217 pyruvate dehydrogenase; Provisional; Region: PRK09124 246196006218 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246196006219 PYR/PP interface [polypeptide binding]; other site 246196006220 dimer interface [polypeptide binding]; other site 246196006221 tetramer interface [polypeptide binding]; other site 246196006222 TPP binding site [chemical binding]; other site 246196006223 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196006224 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 246196006225 TPP-binding site [chemical binding]; other site 246196006226 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196006227 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196006228 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196006229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006230 S-adenosylmethionine binding site [chemical binding]; other site 246196006231 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196006232 Phosphotransferase enzyme family; Region: APH; pfam01636 246196006233 putative active site [active] 246196006234 putative substrate binding site [chemical binding]; other site 246196006235 ATP binding site [chemical binding]; other site 246196006236 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196006237 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 246196006238 Cytochrome P450; Region: p450; cl12078 246196006239 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196006240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006242 short chain dehydrogenase; Provisional; Region: PRK07832 246196006243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006244 NAD(P) binding site [chemical binding]; other site 246196006245 active site 246196006246 alkaline phosphatase; Provisional; Region: PRK10518 246196006247 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 246196006248 dimer interface [polypeptide binding]; other site 246196006249 active site 246196006250 Predicted ATPase [General function prediction only]; Region: COG4637 246196006251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196006252 Walker A/P-loop; other site 246196006253 ATP binding site [chemical binding]; other site 246196006254 DNA polymerase IV; Validated; Region: PRK03352 246196006255 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246196006256 active site 246196006257 DNA binding site [nucleotide binding] 246196006258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006260 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246196006261 Predicted flavoprotein [General function prediction only]; Region: COG0431 246196006262 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 246196006263 catalytic residues [active] 246196006264 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 246196006265 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 246196006266 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 246196006267 Class I ribonucleotide reductase; Region: RNR_I; cd01679 246196006268 active site 246196006269 dimer interface [polypeptide binding]; other site 246196006270 catalytic residues [active] 246196006271 effector binding site; other site 246196006272 R2 peptide binding site; other site 246196006273 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196006274 dimerization interface [polypeptide binding]; other site 246196006275 substrate binding pocket [chemical binding]; other site 246196006276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196006277 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 246196006278 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196006279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006280 putative substrate translocation pore; other site 246196006281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 246196006282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196006283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006285 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196006286 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196006287 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246196006288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006290 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196006291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196006292 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 246196006293 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 246196006294 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 246196006295 dimer interface [polypeptide binding]; other site 246196006296 putative radical transfer pathway; other site 246196006297 diiron center [ion binding]; other site 246196006298 tyrosyl radical; other site 246196006299 Predicted esterase [General function prediction only]; Region: COG0627 246196006300 S-formylglutathione hydrolase; Region: PLN02442 246196006301 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246196006302 potential frameshift: common BLAST hit: gi|126433506|ref|YP_001069197.1| putative monooxygenase 246196006303 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196006304 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196006305 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196006306 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196006307 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 246196006308 putative NAD(P) binding site [chemical binding]; other site 246196006309 putative substrate binding site [chemical binding]; other site 246196006310 catalytic Zn binding site [ion binding]; other site 246196006311 structural Zn binding site [ion binding]; other site 246196006312 dimer interface [polypeptide binding]; other site 246196006313 YCII-related domain; Region: YCII; cl00999 246196006314 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196006315 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246196006316 intersubunit interface [polypeptide binding]; other site 246196006317 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 246196006318 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 246196006319 D-pathway; other site 246196006320 Putative ubiquinol binding site [chemical binding]; other site 246196006321 Low-spin heme (heme b) binding site [chemical binding]; other site 246196006322 Putative water exit pathway; other site 246196006323 Binuclear center (heme o3/CuB) [ion binding]; other site 246196006324 K-pathway; other site 246196006325 Putative proton exit pathway; other site 246196006326 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 246196006327 cytochrome o ubiquinol oxidase subunit I; Provisional; Region: PRK15017 246196006328 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 246196006329 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 246196006330 phosphoserine phosphatase SerB; Region: serB; TIGR00338 246196006331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196006332 motif II; other site 246196006333 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196006334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006335 DNA-binding site [nucleotide binding]; DNA binding site 246196006336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196006337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196006338 homodimer interface [polypeptide binding]; other site 246196006339 catalytic residue [active] 246196006340 Predicted membrane protein [Function unknown]; Region: COG2364 246196006341 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 246196006342 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 246196006343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196006344 Walker A/P-loop; other site 246196006345 ATP binding site [chemical binding]; other site 246196006346 Q-loop/lid; other site 246196006347 ABC transporter signature motif; other site 246196006348 Walker B; other site 246196006349 D-loop; other site 246196006350 H-loop/switch region; other site 246196006351 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196006352 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006353 substrate binding site [chemical binding]; other site 246196006354 oxyanion hole (OAH) forming residues; other site 246196006355 trimer interface [polypeptide binding]; other site 246196006356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006357 S-adenosylmethionine binding site [chemical binding]; other site 246196006358 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 246196006359 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 246196006360 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 246196006361 FOG: WD40-like repeat [Function unknown]; Region: COG1520 246196006362 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196006363 active site 246196006364 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 246196006365 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 246196006366 trimer interface [polypeptide binding]; other site 246196006367 active site 246196006368 substrate binding site [chemical binding]; other site 246196006369 CoA binding site [chemical binding]; other site 246196006370 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 246196006371 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 246196006372 homotetramer interface [polypeptide binding]; other site 246196006373 FMN binding site [chemical binding]; other site 246196006374 homodimer contacts [polypeptide binding]; other site 246196006375 putative active site [active] 246196006376 putative substrate binding site [chemical binding]; other site 246196006377 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196006378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196006379 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196006380 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196006381 glycosyltransferase, MGT family; Region: MGT; TIGR01426 246196006382 active site 246196006383 TDP-binding site; other site 246196006384 acceptor substrate-binding pocket; other site 246196006385 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 246196006386 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196006387 [2Fe-2S] cluster binding site [ion binding]; other site 246196006388 iron-sulfur cluster [ion binding]; other site 246196006389 Uncharacterized conserved protein [Function unknown]; Region: COG3349 246196006390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196006391 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 246196006392 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 246196006393 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 246196006394 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 246196006395 active site lid residues [active] 246196006396 substrate binding pocket [chemical binding]; other site 246196006397 catalytic residues [active] 246196006398 substrate-Mg2+ binding site; other site 246196006399 aspartate-rich region 1; other site 246196006400 aspartate-rich region 2; other site 246196006401 phytoene desaturase; Region: crtI_fam; TIGR02734 246196006402 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196006403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196006404 Uncharacterized conserved protein [Function unknown]; Region: COG1543 246196006405 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 246196006406 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 246196006407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006408 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196006409 S-adenosylmethionine binding site [chemical binding]; other site 246196006410 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 246196006411 Ligand binding site [chemical binding]; other site 246196006412 Electron transfer flavoprotein domain; Region: ETF; pfam01012 246196006413 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 246196006414 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 246196006415 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 246196006416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006417 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196006418 NAD(P) binding site [chemical binding]; other site 246196006419 active site 246196006420 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 246196006421 putative FMN binding site [chemical binding]; other site 246196006422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 246196006423 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246196006424 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196006425 putative acyl-acceptor binding pocket; other site 246196006426 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 246196006427 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 246196006428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196006429 catalytic residue [active] 246196006430 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 246196006431 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 246196006432 Ligand Binding Site [chemical binding]; other site 246196006433 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 246196006434 4-coumarate--CoA ligase; Region: PLN02246 246196006435 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 246196006436 acyl-activating enzyme (AAE) consensus motif; other site 246196006437 active site 246196006438 putative CoA binding site [chemical binding]; other site 246196006439 AMP binding site [chemical binding]; other site 246196006440 Protein of unknown function (DUF419); Region: DUF419; pfam04237 246196006441 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 246196006442 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 246196006443 nucleotide binding pocket [chemical binding]; other site 246196006444 K-X-D-G motif; other site 246196006445 catalytic site [active] 246196006446 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 246196006447 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 246196006448 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 246196006449 Dimer interface [polypeptide binding]; other site 246196006450 BRCT sequence motif; other site 246196006451 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 246196006452 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 246196006453 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196006454 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 246196006455 6-phosphofructokinase; Provisional; Region: PRK03202 246196006456 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 246196006457 active site 246196006458 ADP/pyrophosphate binding site [chemical binding]; other site 246196006459 dimerization interface [polypeptide binding]; other site 246196006460 allosteric effector site; other site 246196006461 fructose-1,6-bisphosphate binding site; other site 246196006462 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 246196006463 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 246196006464 GatB domain; Region: GatB_Yqey; smart00845 246196006465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006467 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 246196006468 Predicted membrane protein [Function unknown]; Region: COG2259 246196006469 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 246196006470 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 246196006471 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196006472 PYR/PP interface [polypeptide binding]; other site 246196006473 dimer interface [polypeptide binding]; other site 246196006474 TPP binding site [chemical binding]; other site 246196006475 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196006476 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 246196006477 TPP-binding site [chemical binding]; other site 246196006478 dimer interface [polypeptide binding]; other site 246196006479 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 246196006480 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 246196006481 putative valine binding site [chemical binding]; other site 246196006482 dimer interface [polypeptide binding]; other site 246196006483 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 246196006484 ketol-acid reductoisomerase; Provisional; Region: PRK05479 246196006485 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 246196006486 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 246196006487 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 246196006488 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246196006489 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246196006490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196006491 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 246196006492 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 246196006493 ligand binding site [chemical binding]; other site 246196006494 NAD binding site [chemical binding]; other site 246196006495 dimerization interface [polypeptide binding]; other site 246196006496 catalytic site [active] 246196006497 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 246196006498 putative L-serine binding site [chemical binding]; other site 246196006499 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 246196006500 tartrate dehydrogenase; Region: TTC; TIGR02089 246196006501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196006503 putative substrate translocation pore; other site 246196006504 Secretory lipase; Region: LIP; pfam03583 246196006505 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196006506 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 246196006507 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196006508 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196006509 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 246196006510 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 246196006511 HIGH motif; other site 246196006512 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 246196006513 active site 246196006514 KMSKS motif; other site 246196006515 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196006516 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196006517 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196006518 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 246196006519 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 246196006520 substrate binding site [chemical binding]; other site 246196006521 ligand binding site [chemical binding]; other site 246196006522 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 246196006523 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 246196006524 substrate binding site [chemical binding]; other site 246196006525 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 246196006526 IHF - DNA interface [nucleotide binding]; other site 246196006527 IHF dimer interface [polypeptide binding]; other site 246196006528 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 246196006529 active site 246196006530 Ap6A binding site [chemical binding]; other site 246196006531 nudix motif; other site 246196006532 metal binding site [ion binding]; metal-binding site 246196006533 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196006534 catalytic core [active] 246196006535 polyphosphate kinase; Provisional; Region: PRK05443 246196006536 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 246196006537 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 246196006538 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 246196006539 putative domain interface [polypeptide binding]; other site 246196006540 putative active site [active] 246196006541 catalytic site [active] 246196006542 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 246196006543 putative domain interface [polypeptide binding]; other site 246196006544 putative active site [active] 246196006545 catalytic site [active] 246196006546 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 246196006547 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 246196006548 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 246196006549 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 246196006550 cystathionine gamma-lyase; Validated; Region: PRK07582 246196006551 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196006552 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196006553 catalytic residue [active] 246196006554 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 246196006555 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 246196006556 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 246196006557 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 246196006558 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196006559 AsnC family; Region: AsnC_trans_reg; pfam01037 246196006560 thiamine monophosphate kinase; Provisional; Region: PRK05731 246196006561 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 246196006562 ATP binding site [chemical binding]; other site 246196006563 dimerization interface [polypeptide binding]; other site 246196006564 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 246196006565 ligand binding site [chemical binding]; other site 246196006566 active site 246196006567 UGI interface [polypeptide binding]; other site 246196006568 catalytic site [active] 246196006569 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 246196006570 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 246196006571 DAK2 domain; Region: Dak2; pfam02734 246196006572 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 246196006573 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 246196006574 generic binding surface II; other site 246196006575 ssDNA binding site; other site 246196006576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196006577 ATP binding site [chemical binding]; other site 246196006578 putative Mg++ binding site [ion binding]; other site 246196006579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196006580 nucleotide binding region [chemical binding]; other site 246196006581 ATP-binding site [chemical binding]; other site 246196006582 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 246196006583 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246196006584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196006585 Coenzyme A binding pocket [chemical binding]; other site 246196006586 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196006587 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196006588 active site 246196006589 catalytic tetrad [active] 246196006590 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196006591 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196006592 active site 246196006593 catalytic tetrad [active] 246196006594 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196006595 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196006596 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246196006597 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 246196006598 catalytic residues [active] 246196006599 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 246196006600 putative active site [active] 246196006601 redox center [active] 246196006602 pyruvate carboxylase; Reviewed; Region: PRK12999 246196006603 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196006604 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196006605 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196006606 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 246196006607 active site 246196006608 catalytic residues [active] 246196006609 metal binding site [ion binding]; metal-binding site 246196006610 homodimer binding site [polypeptide binding]; other site 246196006611 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196006612 carboxyltransferase (CT) interaction site; other site 246196006613 biotinylation site [posttranslational modification]; other site 246196006614 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 246196006615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006616 S-adenosylmethionine binding site [chemical binding]; other site 246196006617 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 246196006618 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 246196006619 active site 246196006620 (T/H)XGH motif; other site 246196006621 Hemerythrin-like domain; Region: Hr-like; cd12108 246196006622 Fe binding site [ion binding]; other site 246196006623 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 246196006624 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 246196006625 ribonuclease III; Reviewed; Region: rnc; PRK00102 246196006626 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 246196006627 dimerization interface [polypeptide binding]; other site 246196006628 active site 246196006629 metal binding site [ion binding]; metal-binding site 246196006630 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 246196006631 dsRNA binding site [nucleotide binding]; other site 246196006632 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 246196006633 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 246196006634 DNA binding site [nucleotide binding] 246196006635 catalytic residue [active] 246196006636 H2TH interface [polypeptide binding]; other site 246196006637 putative catalytic residues [active] 246196006638 turnover-facilitating residue; other site 246196006639 intercalation triad [nucleotide binding]; other site 246196006640 8OG recognition residue [nucleotide binding]; other site 246196006641 putative reading head residues; other site 246196006642 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246196006643 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246196006644 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 246196006645 acylphosphatase; Provisional; Region: PRK14422 246196006646 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 246196006647 AAA domain; Region: AAA_23; pfam13476 246196006648 Walker A/P-loop; other site 246196006649 ATP binding site [chemical binding]; other site 246196006650 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 246196006651 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 246196006652 ABC transporter signature motif; other site 246196006653 Walker B; other site 246196006654 D-loop; other site 246196006655 H-loop/switch region; other site 246196006656 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 246196006657 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 246196006658 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196006659 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 246196006660 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 246196006661 Nitrogen regulatory protein P-II; Region: P-II; smart00938 246196006662 PII uridylyl-transferase; Provisional; Region: PRK03381 246196006663 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246196006664 metal binding triad; other site 246196006665 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 246196006666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196006667 Zn2+ binding site [ion binding]; other site 246196006668 Mg2+ binding site [ion binding]; other site 246196006669 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 246196006670 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 246196006671 Helix-turn-helix domain; Region: HTH_31; pfam13560 246196006672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196006673 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196006674 active site 246196006675 catalytic tetrad [active] 246196006676 signal recognition particle protein; Provisional; Region: PRK10867 246196006677 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 246196006678 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 246196006679 P loop; other site 246196006680 GTP binding site [chemical binding]; other site 246196006681 Signal peptide binding domain; Region: SRP_SPB; pfam02978 246196006682 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196006683 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 246196006684 active site 246196006685 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 246196006686 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 246196006687 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 246196006688 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 246196006689 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196006690 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 246196006691 hypothetical protein; Provisional; Region: PRK02821 246196006692 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 246196006693 G-X-X-G motif; other site 246196006694 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 246196006695 RimM N-terminal domain; Region: RimM; pfam01782 246196006696 PRC-barrel domain; Region: PRC; pfam05239 246196006697 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 246196006698 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 246196006699 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 246196006700 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 246196006701 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 246196006702 Catalytic site [active] 246196006703 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 246196006704 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 246196006705 RNA/DNA hybrid binding site [nucleotide binding]; other site 246196006706 active site 246196006707 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 246196006708 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246196006709 Uncharacterized conserved protein [Function unknown]; Region: COG0397 246196006710 hypothetical protein; Validated; Region: PRK00029 246196006711 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 246196006712 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196006713 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196006714 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 246196006715 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 246196006716 tetrameric interface [polypeptide binding]; other site 246196006717 NAD binding site [chemical binding]; other site 246196006718 catalytic residues [active] 246196006719 hypothetical protein; Provisional; Region: PRK06062 246196006720 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196006721 inhibitor-cofactor binding pocket; inhibition site 246196006722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196006723 catalytic residue [active] 246196006724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196006725 UMP phosphatase; Provisional; Region: PRK10444 246196006726 active site 246196006727 motif I; other site 246196006728 motif II; other site 246196006729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196006730 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196006731 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006732 DNA-binding site [nucleotide binding]; DNA binding site 246196006733 FCD domain; Region: FCD; pfam07729 246196006734 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246196006735 homotrimer interaction site [polypeptide binding]; other site 246196006736 putative active site [active] 246196006737 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 246196006738 putative hydrophobic ligand binding site [chemical binding]; other site 246196006739 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 246196006740 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196006741 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196006742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 246196006743 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196006744 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196006745 Walker A/P-loop; other site 246196006746 ATP binding site [chemical binding]; other site 246196006747 Q-loop/lid; other site 246196006748 ABC transporter signature motif; other site 246196006749 Walker B; other site 246196006750 D-loop; other site 246196006751 H-loop/switch region; other site 246196006752 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196006753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196006754 dimer interface [polypeptide binding]; other site 246196006755 conserved gate region; other site 246196006756 putative PBP binding loops; other site 246196006757 ABC-ATPase subunit interface; other site 246196006758 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196006759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196006760 dimer interface [polypeptide binding]; other site 246196006761 conserved gate region; other site 246196006762 ABC-ATPase subunit interface; other site 246196006763 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196006764 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196006765 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196006766 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 246196006767 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196006768 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196006769 catalytic loop [active] 246196006770 iron binding site [ion binding]; other site 246196006771 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196006772 Amidohydrolase; Region: Amidohydro_5; pfam13594 246196006773 Amidohydrolase; Region: Amidohydro_4; pfam13147 246196006774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196006775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196006776 active site 246196006777 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 246196006778 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 246196006779 tetramer interface [polypeptide binding]; other site 246196006780 TPP-binding site [chemical binding]; other site 246196006781 heterodimer interface [polypeptide binding]; other site 246196006782 phosphorylation loop region [posttranslational modification] 246196006783 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 246196006784 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 246196006785 PYR/PP interface [polypeptide binding]; other site 246196006786 dimer interface [polypeptide binding]; other site 246196006787 TPP binding site [chemical binding]; other site 246196006788 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196006789 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 246196006790 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196006791 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196006792 acyl-CoA thioesterase II; Region: tesB; TIGR00189 246196006793 active site 246196006794 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196006795 catalytic triad [active] 246196006796 dimer interface [polypeptide binding]; other site 246196006797 AMP-binding enzyme; Region: AMP-binding; pfam00501 246196006798 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006799 acyl-activating enzyme (AAE) consensus motif; other site 246196006800 AMP binding site [chemical binding]; other site 246196006801 active site 246196006802 CoA binding site [chemical binding]; other site 246196006803 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196006804 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196006805 TPP-binding site [chemical binding]; other site 246196006806 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 246196006807 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196006808 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196006809 AsnC family; Region: AsnC_trans_reg; pfam01037 246196006810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006812 putative substrate translocation pore; other site 246196006813 potential frameshift: common BLAST hit: gi|384150784|ref|YP_005533600.1| MFS transporter metabolite:H+ symporter 246196006814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006815 Cutinase; Region: Cutinase; pfam01083 246196006816 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196006817 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196006818 active site 246196006819 catalytic tetrad [active] 246196006820 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196006821 MarR family; Region: MarR_2; pfam12802 246196006822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006823 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196006824 NAD(P) binding site [chemical binding]; other site 246196006825 active site 246196006826 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196006827 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196006828 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196006829 DNA-binding site [nucleotide binding]; DNA binding site 246196006830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196006831 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196006832 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 246196006833 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196006834 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196006835 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196006836 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 246196006837 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196006838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006839 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196006840 putative substrate translocation pore; other site 246196006841 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 246196006842 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196006843 inhibitor-cofactor binding pocket; inhibition site 246196006844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196006845 catalytic residue [active] 246196006846 succinic semialdehyde dehydrogenase; Region: PLN02278 246196006847 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 246196006848 tetramerization interface [polypeptide binding]; other site 246196006849 NAD(P) binding site [chemical binding]; other site 246196006850 catalytic residues [active] 246196006851 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196006852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006853 DNA-binding site [nucleotide binding]; DNA binding site 246196006854 FCD domain; Region: FCD; pfam07729 246196006855 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196006856 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246196006857 FAD binding domain; Region: FAD_binding_4; pfam01565 246196006858 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 246196006859 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 246196006860 Cysteine-rich domain; Region: CCG; pfam02754 246196006861 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 246196006862 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 246196006863 metal binding site [ion binding]; metal-binding site 246196006864 dimer interface [polypeptide binding]; other site 246196006865 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 246196006866 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196006867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196006868 homodimer interface [polypeptide binding]; other site 246196006869 catalytic residue [active] 246196006870 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 246196006871 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196006872 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246196006873 active site 246196006874 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196006875 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 246196006876 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 246196006877 NAD binding site [chemical binding]; other site 246196006878 ligand binding site [chemical binding]; other site 246196006879 catalytic site [active] 246196006880 putative amidase; Provisional; Region: PRK06169 246196006881 Amidase; Region: Amidase; pfam01425 246196006882 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 246196006883 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 246196006884 active site 246196006885 catalytic triad [active] 246196006886 oxyanion hole [active] 246196006887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196006888 dimer interface [polypeptide binding]; other site 246196006889 conserved gate region; other site 246196006890 putative PBP binding loops; other site 246196006891 ABC-ATPase subunit interface; other site 246196006892 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196006893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196006894 dimer interface [polypeptide binding]; other site 246196006895 conserved gate region; other site 246196006896 putative PBP binding loops; other site 246196006897 ABC-ATPase subunit interface; other site 246196006898 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196006899 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196006900 Walker A/P-loop; other site 246196006901 ATP binding site [chemical binding]; other site 246196006902 Q-loop/lid; other site 246196006903 ABC transporter signature motif; other site 246196006904 Walker B; other site 246196006905 D-loop; other site 246196006906 H-loop/switch region; other site 246196006907 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196006908 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 246196006909 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 246196006910 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 246196006911 substrate binding site [chemical binding]; other site 246196006912 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 246196006913 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246196006914 substrate binding site [chemical binding]; other site 246196006915 ligand binding site [chemical binding]; other site 246196006916 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196006917 tetramer interface [polypeptide binding]; other site 246196006918 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 246196006919 active site 246196006920 Mg2+/Mn2+ binding site [ion binding]; other site 246196006921 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196006922 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196006923 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196006924 hypothetical protein; Reviewed; Region: PRK12497 246196006925 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 246196006926 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 246196006927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196006928 Walker A motif; other site 246196006929 ATP binding site [chemical binding]; other site 246196006930 Walker B motif; other site 246196006931 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 246196006932 DNA protecting protein DprA; Region: dprA; TIGR00732 246196006933 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 246196006934 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 246196006935 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246196006936 FAD binding pocket [chemical binding]; other site 246196006937 FAD binding motif [chemical binding]; other site 246196006938 phosphate binding motif [ion binding]; other site 246196006939 NAD binding pocket [chemical binding]; other site 246196006940 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 246196006941 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 246196006942 putative active site [active] 246196006943 putative substrate binding site [chemical binding]; other site 246196006944 putative FMN binding site [chemical binding]; other site 246196006945 putative catalytic residues [active] 246196006946 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196006947 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 246196006948 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196006949 active site 246196006950 DNA binding site [nucleotide binding] 246196006951 Int/Topo IB signature motif; other site 246196006952 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196006953 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196006954 putative hydrolase; Provisional; Region: PRK11460 246196006955 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 246196006956 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196006957 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246196006958 Peptidase family M23; Region: Peptidase_M23; pfam01551 246196006959 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 246196006960 rRNA interaction site [nucleotide binding]; other site 246196006961 S8 interaction site; other site 246196006962 putative laminin-1 binding site; other site 246196006963 elongation factor Ts; Provisional; Region: tsf; PRK09377 246196006964 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 246196006965 Elongation factor TS; Region: EF_TS; pfam00889 246196006966 Elongation factor TS; Region: EF_TS; pfam00889 246196006967 amidase; Provisional; Region: PRK07869 246196006968 Amidase; Region: Amidase; cl11426 246196006969 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246196006970 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246196006971 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246196006972 Walker A/P-loop; other site 246196006973 ATP binding site [chemical binding]; other site 246196006974 Q-loop/lid; other site 246196006975 ABC transporter signature motif; other site 246196006976 Walker B; other site 246196006977 D-loop; other site 246196006978 H-loop/switch region; other site 246196006979 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196006980 tyramine oxidase; Provisional; Region: tynA; PRK11504 246196006981 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 246196006982 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 246196006983 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 246196006984 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 246196006985 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 246196006986 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 246196006987 dimerization interface [polypeptide binding]; other site 246196006988 ligand binding site [chemical binding]; other site 246196006989 NADP binding site [chemical binding]; other site 246196006990 catalytic site [active] 246196006991 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 246196006992 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196006993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006994 DNA-binding site [nucleotide binding]; DNA binding site 246196006995 FCD domain; Region: FCD; pfam07729 246196006996 Dehydroquinase class II; Region: DHquinase_II; pfam01220 246196006997 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 246196006998 trimer interface [polypeptide binding]; other site 246196006999 active site 246196007000 SCP-2 sterol transfer family; Region: SCP2; cl01225 246196007001 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196007002 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196007003 classical (c) SDRs; Region: SDR_c; cd05233 246196007004 NAD(P) binding site [chemical binding]; other site 246196007005 active site 246196007006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196007007 classical (c) SDRs; Region: SDR_c; cd05233 246196007008 NAD(P) binding site [chemical binding]; other site 246196007009 active site 246196007010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007011 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 246196007012 putative substrate translocation pore; other site 246196007013 MarR family; Region: MarR; pfam01047 246196007014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196007015 S-adenosylmethionine binding site [chemical binding]; other site 246196007016 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 246196007017 putative nucleotide binding site [chemical binding]; other site 246196007018 uridine monophosphate binding site [chemical binding]; other site 246196007019 homohexameric interface [polypeptide binding]; other site 246196007020 ribosome recycling factor; Reviewed; Region: frr; PRK00083 246196007021 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 246196007022 hinge region; other site 246196007023 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 246196007024 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 246196007025 EamA-like transporter family; Region: EamA; pfam00892 246196007026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196007027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196007028 dimerization interface [polypeptide binding]; other site 246196007029 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 246196007030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196007031 FeS/SAM binding site; other site 246196007032 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007034 DNA-binding site [nucleotide binding]; DNA binding site 246196007035 FCD domain; Region: FCD; pfam07729 246196007036 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196007037 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196007038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007039 NAD(P) binding site [chemical binding]; other site 246196007040 active site 246196007041 D-galactonate transporter; Region: 2A0114; TIGR00893 246196007042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007043 putative substrate translocation pore; other site 246196007044 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 246196007045 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 246196007046 NAD binding site [chemical binding]; other site 246196007047 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 246196007048 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196007049 NAD binding site [chemical binding]; other site 246196007050 catalytic residues [active] 246196007051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196007052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196007053 Ecdysteroid kinase; Region: EcKinase; cl17738 246196007054 Phosphotransferase enzyme family; Region: APH; pfam01636 246196007055 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 246196007056 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 246196007057 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 246196007058 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 246196007059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196007060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196007061 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196007062 Cytochrome P450; Region: p450; cl12078 246196007063 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 246196007064 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246196007065 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196007066 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196007067 Strictosidine synthase; Region: Str_synth; pfam03088 246196007068 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196007069 Cytochrome P450; Region: p450; cl12078 246196007070 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196007071 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196007072 NAD(P) binding site [chemical binding]; other site 246196007073 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 246196007074 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196007075 classical (c) SDRs; Region: SDR_c; cd05233 246196007076 NAD(P) binding site [chemical binding]; other site 246196007077 active site 246196007078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196007079 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196007080 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196007081 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196007082 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196007083 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196007084 xanthine permease; Region: pbuX; TIGR03173 246196007085 Cupin domain; Region: Cupin_2; cl17218 246196007086 Domain of unknown function (DUF427); Region: DUF427; pfam04248 246196007087 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 246196007088 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 246196007089 DNA photolyase; Region: DNA_photolyase; pfam00875 246196007090 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 246196007091 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 246196007092 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 246196007093 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 246196007094 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 246196007095 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 246196007096 active site 246196007097 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 246196007098 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 246196007099 putative substrate binding region [chemical binding]; other site 246196007100 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 246196007101 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 246196007102 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 246196007103 Predicted acetyltransferase [General function prediction only]; Region: COG3393 246196007104 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 246196007105 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 246196007106 putative catalytic residues [active] 246196007107 tetracycline repressor protein TetR; Provisional; Region: PRK13756 246196007108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196007109 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196007110 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 246196007111 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196007112 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196007113 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196007114 CoenzymeA binding site [chemical binding]; other site 246196007115 subunit interaction site [polypeptide binding]; other site 246196007116 PHB binding site; other site 246196007117 methionine aminopeptidase; Provisional; Region: PRK12318 246196007118 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246196007119 active site 246196007120 cobyric acid synthase; Provisional; Region: PRK00784 246196007121 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196007122 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196007123 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 246196007124 catalytic triad [active] 246196007125 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 246196007126 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 246196007127 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196007128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196007129 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196007130 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 246196007131 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196007132 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196007133 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 246196007134 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 246196007135 active site 246196007136 dimer interface [polypeptide binding]; other site 246196007137 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 246196007138 Ligand Binding Site [chemical binding]; other site 246196007139 Molecular Tunnel; other site 246196007140 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196007141 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246196007142 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196007143 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 246196007144 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 246196007145 catalytic triad [active] 246196007146 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196007147 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196007148 NAD(P) binding site [chemical binding]; other site 246196007149 catalytic residues [active] 246196007150 short chain dehydrogenase; Provisional; Region: PRK06057 246196007151 classical (c) SDRs; Region: SDR_c; cd05233 246196007152 NAD(P) binding site [chemical binding]; other site 246196007153 active site 246196007154 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007156 DNA-binding site [nucleotide binding]; DNA binding site 246196007157 FCD domain; Region: FCD; pfam07729 246196007158 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196007159 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196007160 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196007161 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 246196007162 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 246196007163 active site 246196007164 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 246196007165 heterodimer interface [polypeptide binding]; other site 246196007166 active site 246196007167 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 246196007168 tetramer interface [polypeptide binding]; other site 246196007169 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 246196007170 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007172 DNA-binding site [nucleotide binding]; DNA binding site 246196007173 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196007174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196007175 dimerization interface [polypeptide binding]; other site 246196007176 putative DNA binding site [nucleotide binding]; other site 246196007177 putative Zn2+ binding site [ion binding]; other site 246196007178 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 246196007179 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 246196007180 PDGLE domain; Region: PDGLE; pfam13190 246196007181 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 246196007182 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196007183 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196007184 Walker A/P-loop; other site 246196007185 ATP binding site [chemical binding]; other site 246196007186 Q-loop/lid; other site 246196007187 ABC transporter signature motif; other site 246196007188 Walker B; other site 246196007189 D-loop; other site 246196007190 H-loop/switch region; other site 246196007191 mycothione reductase; Reviewed; Region: PRK07846 246196007192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196007193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196007194 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246196007195 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246196007196 malate:quinone oxidoreductase; Validated; Region: PRK05257 246196007197 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 246196007198 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 246196007199 Coenzyme A binding pocket [chemical binding]; other site 246196007200 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 246196007201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246196007202 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 246196007203 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 246196007204 metal ion-dependent adhesion site (MIDAS); other site 246196007205 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 246196007206 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 246196007207 Walker A motif; other site 246196007208 homodimer interface [polypeptide binding]; other site 246196007209 ATP binding site [chemical binding]; other site 246196007210 hydroxycobalamin binding site [chemical binding]; other site 246196007211 Walker B motif; other site 246196007212 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 246196007213 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 246196007214 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 246196007215 catalytic triad [active] 246196007216 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 246196007217 siroheme synthase; Provisional; Region: cysG; PRK10637 246196007218 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 246196007219 active site 246196007220 SAM binding site [chemical binding]; other site 246196007221 homodimer interface [polypeptide binding]; other site 246196007222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007223 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 246196007224 putative substrate translocation pore; other site 246196007225 prolyl-tRNA synthetase; Provisional; Region: PRK09194 246196007226 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 246196007227 dimer interface [polypeptide binding]; other site 246196007228 motif 1; other site 246196007229 active site 246196007230 motif 2; other site 246196007231 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 246196007232 putative deacylase active site [active] 246196007233 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246196007234 active site 246196007235 motif 3; other site 246196007236 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 246196007237 anticodon binding site; other site 246196007238 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246196007239 dinuclear metal binding motif [ion binding]; other site 246196007240 ribosome maturation protein RimP; Reviewed; Region: PRK00092 246196007241 Sm and related proteins; Region: Sm_like; cl00259 246196007242 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 246196007243 putative oligomer interface [polypeptide binding]; other site 246196007244 putative RNA binding site [nucleotide binding]; other site 246196007245 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 246196007246 NusA N-terminal domain; Region: NusA_N; pfam08529 246196007247 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 246196007248 RNA binding site [nucleotide binding]; other site 246196007249 homodimer interface [polypeptide binding]; other site 246196007250 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 246196007251 G-X-X-G motif; other site 246196007252 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 246196007253 G-X-X-G motif; other site 246196007254 Protein of unknown function (DUF448); Region: DUF448; pfam04296 246196007255 putative RNA binding cleft [nucleotide binding]; other site 246196007256 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246196007257 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246196007258 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 246196007259 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 246196007260 G1 box; other site 246196007261 putative GEF interaction site [polypeptide binding]; other site 246196007262 GTP/Mg2+ binding site [chemical binding]; other site 246196007263 Switch I region; other site 246196007264 G2 box; other site 246196007265 G3 box; other site 246196007266 Switch II region; other site 246196007267 G4 box; other site 246196007268 G5 box; other site 246196007269 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 246196007270 Translation-initiation factor 2; Region: IF-2; pfam11987 246196007271 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 246196007272 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 246196007273 DHH family; Region: DHH; pfam01368 246196007274 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 246196007275 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 246196007276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196007277 S-adenosylmethionine binding site [chemical binding]; other site 246196007278 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196007279 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196007280 Walker A/P-loop; other site 246196007281 ATP binding site [chemical binding]; other site 246196007282 Q-loop/lid; other site 246196007283 ABC transporter signature motif; other site 246196007284 Walker B; other site 246196007285 D-loop; other site 246196007286 H-loop/switch region; other site 246196007287 NMT1/THI5 like; Region: NMT1; pfam09084 246196007288 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196007289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007290 dimer interface [polypeptide binding]; other site 246196007291 conserved gate region; other site 246196007292 putative PBP binding loops; other site 246196007293 ABC-ATPase subunit interface; other site 246196007294 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196007295 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196007296 DNA binding site [nucleotide binding] 246196007297 domain linker motif; other site 246196007298 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196007299 dimerization interface [polypeptide binding]; other site 246196007300 ligand binding site [chemical binding]; other site 246196007301 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196007302 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196007303 Protein of unknown function (DUF993); Region: DUF993; pfam06187 246196007304 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196007305 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 246196007306 EamA-like transporter family; Region: EamA; pfam00892 246196007307 enoyl-CoA hydratase; Provisional; Region: PRK06190 246196007308 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196007309 substrate binding site [chemical binding]; other site 246196007310 oxyanion hole (OAH) forming residues; other site 246196007311 trimer interface [polypeptide binding]; other site 246196007312 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 246196007313 Predicted acyl esterases [General function prediction only]; Region: COG2936 246196007314 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 246196007315 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196007316 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196007317 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196007318 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 246196007319 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246196007320 active site 246196007321 metal binding site [ion binding]; metal-binding site 246196007322 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 246196007323 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 246196007324 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 246196007325 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 246196007326 RNA binding site [nucleotide binding]; other site 246196007327 active site 246196007328 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 246196007329 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196007330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196007331 active site 246196007332 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 246196007333 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196007334 active site 246196007335 dimer interface [polypeptide binding]; other site 246196007336 non-prolyl cis peptide bond; other site 246196007337 insertion regions; other site 246196007338 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 246196007339 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 246196007340 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 246196007341 FeoA domain; Region: FeoA; pfam04023 246196007342 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 246196007343 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 246196007344 active site 246196007345 Riboflavin kinase; Region: Flavokinase; smart00904 246196007346 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 246196007347 16S/18S rRNA binding site [nucleotide binding]; other site 246196007348 S13e-L30e interaction site [polypeptide binding]; other site 246196007349 25S rRNA binding site [nucleotide binding]; other site 246196007350 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 246196007351 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 246196007352 oligomer interface [polypeptide binding]; other site 246196007353 RNA binding site [nucleotide binding]; other site 246196007354 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 246196007355 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 246196007356 RNase E interface [polypeptide binding]; other site 246196007357 trimer interface [polypeptide binding]; other site 246196007358 active site 246196007359 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 246196007360 putative nucleic acid binding region [nucleotide binding]; other site 246196007361 G-X-X-G motif; other site 246196007362 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 246196007363 RNA binding site [nucleotide binding]; other site 246196007364 domain interface; other site 246196007365 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246196007366 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246196007367 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246196007368 beta-lactamase TEM; Provisional; Region: PRK15442 246196007369 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 246196007370 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 246196007371 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 246196007372 hexamer interface [polypeptide binding]; other site 246196007373 ligand binding site [chemical binding]; other site 246196007374 putative active site [active] 246196007375 NAD(P) binding site [chemical binding]; other site 246196007376 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196007377 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 246196007378 AsnC family; Region: AsnC_trans_reg; pfam01037 246196007379 META domain; Region: META; pfam03724 246196007380 META domain; Region: META; pfam03724 246196007381 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196007382 dihydrodipicolinate reductase; Provisional; Region: PRK00048 246196007383 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196007384 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 246196007385 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246196007386 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196007387 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246196007388 thymidylate synthase; Reviewed; Region: thyA; PRK01827 246196007389 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 246196007390 dimerization interface [polypeptide binding]; other site 246196007391 active site 246196007392 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246196007393 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 246196007394 folate binding site [chemical binding]; other site 246196007395 NADP+ binding site [chemical binding]; other site 246196007396 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196007397 acyl-activating enzyme (AAE) consensus motif; other site 246196007398 Integrase core domain; Region: rve_3; pfam13683 246196007399 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 246196007400 Helix-turn-helix domain; Region: HTH_38; pfam13936 246196007401 Integrase core domain; Region: rve; pfam00665 246196007402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196007403 Transposase; Region: HTH_Tnp_1; cl17663 246196007404 MMPL family; Region: MMPL; pfam03176 246196007405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 246196007406 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 246196007407 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196007408 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 246196007409 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007411 DNA-binding site [nucleotide binding]; DNA binding site 246196007412 FCD domain; Region: FCD; pfam07729 246196007413 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 246196007414 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 246196007415 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 246196007416 dimer interface [polypeptide binding]; other site 246196007417 active site 246196007418 catalytic residue [active] 246196007419 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 246196007420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196007421 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 246196007422 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 246196007423 classical (c) SDRs; Region: SDR_c; cd05233 246196007424 NAD(P) binding site [chemical binding]; other site 246196007425 active site 246196007426 Uncharacterized conserved protein [Function unknown]; Region: COG1359 246196007427 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 246196007428 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196007429 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 246196007430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196007431 Coenzyme A binding pocket [chemical binding]; other site 246196007432 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 246196007433 Competence-damaged protein; Region: CinA; pfam02464 246196007434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196007435 non-specific DNA binding site [nucleotide binding]; other site 246196007436 salt bridge; other site 246196007437 sequence-specific DNA binding site [nucleotide binding]; other site 246196007438 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 246196007439 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 246196007440 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196007441 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246196007442 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 246196007443 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 246196007444 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 246196007445 HupF/HypC family; Region: HupF_HypC; cl00394 246196007446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246196007447 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196007448 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 246196007449 dimerization interface [polypeptide binding]; other site 246196007450 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 246196007451 ATP binding site [chemical binding]; other site 246196007452 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 246196007453 dimer interface [polypeptide binding]; other site 246196007454 active site 246196007455 Acylphosphatase; Region: Acylphosphatase; pfam00708 246196007456 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 246196007457 HypF finger; Region: zf-HYPF; pfam07503 246196007458 HypF finger; Region: zf-HYPF; pfam07503 246196007459 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 246196007460 HupF/HypC family; Region: HupF_HypC; pfam01455 246196007461 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 246196007462 nickel binding site [ion binding]; other site 246196007463 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 246196007464 NifU-like domain; Region: NifU; cl00484 246196007465 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196007466 iron-sulfur cluster [ion binding]; other site 246196007467 [2Fe-2S] cluster binding site [ion binding]; other site 246196007468 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 246196007469 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 246196007470 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 246196007471 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196007472 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 246196007473 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 246196007474 recombinase A; Provisional; Region: recA; PRK09354 246196007475 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 246196007476 hexamer interface [polypeptide binding]; other site 246196007477 Walker A motif; other site 246196007478 ATP binding site [chemical binding]; other site 246196007479 Walker B motif; other site 246196007480 recombination regulator RecX; Reviewed; Region: recX; PRK00117 246196007481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007482 dimer interface [polypeptide binding]; other site 246196007483 conserved gate region; other site 246196007484 putative PBP binding loops; other site 246196007485 ABC-ATPase subunit interface; other site 246196007486 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246196007487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007488 dimer interface [polypeptide binding]; other site 246196007489 conserved gate region; other site 246196007490 putative PBP binding loops; other site 246196007491 ABC-ATPase subunit interface; other site 246196007492 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 246196007493 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196007494 substrate binding pocket [chemical binding]; other site 246196007495 membrane-bound complex binding site; other site 246196007496 hinge residues; other site 246196007497 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196007498 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196007499 Walker A/P-loop; other site 246196007500 ATP binding site [chemical binding]; other site 246196007501 Q-loop/lid; other site 246196007502 ABC transporter signature motif; other site 246196007503 Walker B; other site 246196007504 D-loop; other site 246196007505 H-loop/switch region; other site 246196007506 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 246196007507 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 246196007508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196007509 FeS/SAM binding site; other site 246196007510 TRAM domain; Region: TRAM; cl01282 246196007511 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 246196007512 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 246196007513 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 246196007514 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 246196007515 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 246196007516 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 246196007517 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 246196007518 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 246196007519 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 246196007520 GTPases [General function prediction only]; Region: HflX; COG2262 246196007521 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 246196007522 HflX GTPase family; Region: HflX; cd01878 246196007523 G1 box; other site 246196007524 GTP/Mg2+ binding site [chemical binding]; other site 246196007525 Switch I region; other site 246196007526 G2 box; other site 246196007527 G3 box; other site 246196007528 Switch II region; other site 246196007529 G4 box; other site 246196007530 G5 box; other site 246196007531 PE-PPE domain; Region: PE-PPE; pfam08237 246196007532 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 246196007533 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 246196007534 molybdopterin cofactor binding site [chemical binding]; other site 246196007535 substrate binding site [chemical binding]; other site 246196007536 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 246196007537 molybdopterin cofactor binding site; other site 246196007538 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 246196007539 LGFP repeat; Region: LGFP; pfam08310 246196007540 LGFP repeat; Region: LGFP; pfam08310 246196007541 LGFP repeat; Region: LGFP; pfam08310 246196007542 LGFP repeat; Region: LGFP; pfam08310 246196007543 LGFP repeat; Region: LGFP; pfam08310 246196007544 LexA repressor; Validated; Region: PRK00215 246196007545 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 246196007546 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 246196007547 Catalytic site [active] 246196007548 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 246196007549 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 246196007550 ATP cone domain; Region: ATP-cone; pfam03477 246196007551 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 246196007552 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196007553 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 246196007554 PAC2 family; Region: PAC2; pfam09754 246196007555 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 246196007556 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 246196007557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196007558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196007559 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246196007560 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 246196007561 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 246196007562 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 246196007563 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 246196007564 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 246196007565 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 246196007566 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 246196007567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196007568 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246196007569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196007570 DNA binding residues [nucleotide binding] 246196007571 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 246196007572 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 246196007573 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 246196007574 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 246196007575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196007576 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246196007577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196007578 DNA binding residues [nucleotide binding] 246196007579 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196007580 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196007581 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 246196007582 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 246196007583 active site 246196007584 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196007585 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 246196007586 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 246196007587 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 246196007588 trimer interface [polypeptide binding]; other site 246196007589 active site 246196007590 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 246196007591 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 246196007592 generic binding surface II; other site 246196007593 ssDNA binding site; other site 246196007594 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 246196007595 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 246196007596 TrkA-N domain; Region: TrkA_N; pfam02254 246196007597 TrkA-C domain; Region: TrkA_C; pfam02080 246196007598 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 246196007599 TrkA-N domain; Region: TrkA_N; pfam02254 246196007600 TrkA-C domain; Region: TrkA_C; pfam02080 246196007601 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196007602 TRAM domain; Region: TRAM; pfam01938 246196007603 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 246196007604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196007605 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246196007606 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246196007607 metal binding site [ion binding]; metal-binding site 246196007608 active site 246196007609 I-site; other site 246196007610 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 246196007611 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 246196007612 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 246196007613 TPP-binding site; other site 246196007614 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246196007615 PYR/PP interface [polypeptide binding]; other site 246196007616 dimer interface [polypeptide binding]; other site 246196007617 TPP binding site [chemical binding]; other site 246196007618 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196007619 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196007620 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 246196007621 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 246196007622 catalytic site [active] 246196007623 putative active site [active] 246196007624 putative substrate binding site [chemical binding]; other site 246196007625 Helicase and RNase D C-terminal; Region: HRDC; smart00341 246196007626 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 246196007627 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 246196007628 substrate binding site [chemical binding]; other site 246196007629 active site 246196007630 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 246196007631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196007632 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 246196007633 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 246196007634 SelR domain; Region: SelR; pfam01641 246196007635 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 246196007636 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196007637 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196007638 hypothetical protein; Provisional; Region: PRK14059 246196007639 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 246196007640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246196007641 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 246196007642 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196007643 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196007644 Clp amino terminal domain; Region: Clp_N; pfam02861 246196007645 Clp amino terminal domain; Region: Clp_N; pfam02861 246196007646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196007647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196007648 dimer interface [polypeptide binding]; other site 246196007649 phosphorylation site [posttranslational modification] 246196007650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196007651 Mg2+ binding site [ion binding]; other site 246196007652 G-X-G motif; other site 246196007653 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007655 DNA-binding site [nucleotide binding]; DNA binding site 246196007656 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196007657 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 246196007658 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 246196007659 gating phenylalanine in ion channel; other site 246196007660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196007661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196007662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196007663 dimerization interface [polypeptide binding]; other site 246196007664 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 246196007665 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 246196007666 LrgA family; Region: LrgA; cl00608 246196007667 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246196007668 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 246196007669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196007670 PAS domain; Region: PAS_9; pfam13426 246196007671 putative active site [active] 246196007672 heme pocket [chemical binding]; other site 246196007673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196007674 Histidine kinase; Region: HisKA_3; pfam07730 246196007675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196007676 ATP binding site [chemical binding]; other site 246196007677 Mg2+ binding site [ion binding]; other site 246196007678 G-X-G motif; other site 246196007679 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196007680 Winged helix-turn helix; Region: HTH_29; pfam13551 246196007681 Homeodomain-like domain; Region: HTH_32; pfam13565 246196007682 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196007683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196007684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196007685 DNA binding residues [nucleotide binding] 246196007686 short chain dehydrogenase; Provisional; Region: PRK06180 246196007687 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196007688 NADP binding site [chemical binding]; other site 246196007689 active site 246196007690 steroid binding site; other site 246196007691 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 246196007692 putative hydrophobic ligand binding site [chemical binding]; other site 246196007693 protein interface [polypeptide binding]; other site 246196007694 gate; other site 246196007695 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196007696 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196007697 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196007698 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246196007699 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246196007700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196007701 Histidine kinase; Region: HisKA_3; pfam07730 246196007702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196007703 Response regulator receiver domain; Region: Response_reg; pfam00072 246196007704 active site 246196007705 phosphorylation site [posttranslational modification] 246196007706 intermolecular recognition site; other site 246196007707 dimerization interface [polypeptide binding]; other site 246196007708 potential frameshift: common BLAST hit: gi|384154271|ref|YP_005537087.1| two-component system response regulator 246196007709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196007710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196007711 DNA binding residues [nucleotide binding] 246196007712 dimerization interface [polypeptide binding]; other site 246196007713 putative transposase OrfB; Reviewed; Region: PHA02517 246196007714 HTH-like domain; Region: HTH_21; pfam13276 246196007715 Integrase core domain; Region: rve; pfam00665 246196007716 Integrase core domain; Region: rve_3; pfam13683 246196007717 Transposase; Region: HTH_Tnp_1; cl17663 246196007718 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196007719 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196007720 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196007721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196007722 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196007723 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196007724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196007725 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196007726 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 246196007727 [4Fe-4S] binding site [ion binding]; other site 246196007728 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 246196007729 molybdopterin cofactor binding site; other site 246196007730 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 246196007731 molybdopterin cofactor binding site; other site 246196007732 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 246196007733 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 246196007734 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 246196007735 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246196007736 RNA binding site [nucleotide binding]; other site 246196007737 Uncharacterized conserved protein [Function unknown]; Region: COG0398 246196007738 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 246196007739 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196007740 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196007741 active site 246196007742 non-prolyl cis peptide bond; other site 246196007743 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196007744 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196007745 active site 246196007746 non-prolyl cis peptide bond; other site 246196007747 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196007748 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196007749 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196007750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196007751 Walker A/P-loop; other site 246196007752 ATP binding site [chemical binding]; other site 246196007753 Q-loop/lid; other site 246196007754 ABC transporter signature motif; other site 246196007755 Walker B; other site 246196007756 D-loop; other site 246196007757 H-loop/switch region; other site 246196007758 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196007759 Walker A/P-loop; other site 246196007760 ATP binding site [chemical binding]; other site 246196007761 Q-loop/lid; other site 246196007762 ABC transporter signature motif; other site 246196007763 Walker B; other site 246196007764 D-loop; other site 246196007765 H-loop/switch region; other site 246196007766 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196007767 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196007768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007769 dimer interface [polypeptide binding]; other site 246196007770 conserved gate region; other site 246196007771 putative PBP binding loops; other site 246196007772 ABC-ATPase subunit interface; other site 246196007773 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196007774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007775 dimer interface [polypeptide binding]; other site 246196007776 conserved gate region; other site 246196007777 putative PBP binding loops; other site 246196007778 ABC-ATPase subunit interface; other site 246196007779 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196007780 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 246196007781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007782 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196007783 putative substrate translocation pore; other site 246196007784 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196007785 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196007786 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196007787 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196007788 classical (c) SDRs; Region: SDR_c; cd05233 246196007789 NAD(P) binding site [chemical binding]; other site 246196007790 active site 246196007791 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196007792 Permease; Region: Permease; pfam02405 246196007793 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196007794 Permease; Region: Permease; pfam02405 246196007795 mce related protein; Region: MCE; pfam02470 246196007796 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196007797 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007798 mce related protein; Region: MCE; pfam02470 246196007799 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007800 mce related protein; Region: MCE; pfam02470 246196007801 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007802 mce related protein; Region: MCE; pfam02470 246196007803 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007804 mce related protein; Region: MCE; pfam02470 246196007805 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196007806 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007807 mce related protein; Region: MCE; pfam02470 246196007808 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196007809 CoenzymeA binding site [chemical binding]; other site 246196007810 subunit interaction site [polypeptide binding]; other site 246196007811 PHB binding site; other site 246196007812 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 246196007813 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196007814 Predicted transcriptional regulators [Transcription]; Region: COG1695 246196007815 Transcriptional regulator PadR-like family; Region: PadR; cl17335 246196007816 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 246196007817 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196007818 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196007819 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 246196007820 classical (c) SDRs; Region: SDR_c; cd05233 246196007821 short chain dehydrogenase; Provisional; Region: PRK08267 246196007822 NAD(P) binding site [chemical binding]; other site 246196007823 active site 246196007824 hypothetical protein; Validated; Region: PRK07121 246196007825 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196007826 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196007827 classical (c) SDRs; Region: SDR_c; cd05233 246196007828 NAD(P) binding site [chemical binding]; other site 246196007829 active site 246196007830 SnoaL-like domain; Region: SnoaL_4; cl17707 246196007831 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196007832 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196007833 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196007834 active site 246196007835 enoyl-CoA hydratase; Provisional; Region: PRK09245 246196007836 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196007837 substrate binding site [chemical binding]; other site 246196007838 oxyanion hole (OAH) forming residues; other site 246196007839 trimer interface [polypeptide binding]; other site 246196007840 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 246196007841 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196007842 NAD binding site [chemical binding]; other site 246196007843 catalytic residues [active] 246196007844 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 246196007845 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196007846 catalytic Zn binding site [ion binding]; other site 246196007847 structural Zn binding site [ion binding]; other site 246196007848 tetramer interface [polypeptide binding]; other site 246196007849 acyl-CoA synthetase; Validated; Region: PRK08316 246196007850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196007851 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196007852 acyl-activating enzyme (AAE) consensus motif; other site 246196007853 acyl-activating enzyme (AAE) consensus motif; other site 246196007854 putative AMP binding site [chemical binding]; other site 246196007855 putative active site [active] 246196007856 putative CoA binding site [chemical binding]; other site 246196007857 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196007858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196007859 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 246196007860 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196007861 NAD(P) binding site [chemical binding]; other site 246196007862 homodimer interface [polypeptide binding]; other site 246196007863 active site 246196007864 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 246196007865 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 246196007866 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 246196007867 active site 246196007868 FMN binding site [chemical binding]; other site 246196007869 substrate binding site [chemical binding]; other site 246196007870 putative catalytic residue [active] 246196007871 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196007872 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196007873 substrate binding pocket [chemical binding]; other site 246196007874 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196007875 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196007876 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196007877 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 246196007878 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 246196007879 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 246196007880 active site 246196007881 Fe binding site [ion binding]; other site 246196007882 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196007883 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196007884 active site 246196007885 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 246196007886 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 246196007887 FAD binding pocket [chemical binding]; other site 246196007888 FAD binding motif [chemical binding]; other site 246196007889 phosphate binding motif [ion binding]; other site 246196007890 beta-alpha-beta structure motif; other site 246196007891 NAD(p) ribose binding residues [chemical binding]; other site 246196007892 NAD binding pocket [chemical binding]; other site 246196007893 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 246196007894 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196007895 catalytic loop [active] 246196007896 iron binding site [ion binding]; other site 246196007897 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196007898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196007899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007900 short chain dehydrogenase; Provisional; Region: PRK07454 246196007901 NAD(P) binding site [chemical binding]; other site 246196007902 active site 246196007903 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246196007904 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196007905 Family description; Region: ACT_7; pfam13840 246196007906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196007907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196007908 short chain dehydrogenase; Validated; Region: PRK08264 246196007909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007910 NAD(P) binding site [chemical binding]; other site 246196007911 active site 246196007912 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196007913 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 246196007914 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246196007915 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196007916 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 246196007917 active site 246196007918 catalytic triad [active] 246196007919 dimer interface [polypeptide binding]; other site 246196007920 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196007921 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196007922 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196007923 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196007924 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196007925 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 246196007926 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 246196007927 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 246196007928 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 246196007929 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196007930 substrate binding site [chemical binding]; other site 246196007931 ATP binding site [chemical binding]; other site 246196007932 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 246196007933 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 246196007934 metal binding site [ion binding]; metal-binding site 246196007935 substrate binding pocket [chemical binding]; other site 246196007936 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196007937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007938 DNA-binding site [nucleotide binding]; DNA binding site 246196007939 FCD domain; Region: FCD; cl11656 246196007940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007941 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196007942 putative substrate translocation pore; other site 246196007943 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196007944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007945 putative substrate translocation pore; other site 246196007946 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 246196007947 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 246196007948 putative NAD(P) binding site [chemical binding]; other site 246196007949 catalytic Zn binding site [ion binding]; other site 246196007950 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196007951 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 246196007952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196007953 dimer interface [polypeptide binding]; other site 246196007954 phosphorylation site [posttranslational modification] 246196007955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196007956 ATP binding site [chemical binding]; other site 246196007957 Mg2+ binding site [ion binding]; other site 246196007958 G-X-G motif; other site 246196007959 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196007960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196007961 active site 246196007962 phosphorylation site [posttranslational modification] 246196007963 intermolecular recognition site; other site 246196007964 dimerization interface [polypeptide binding]; other site 246196007965 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196007966 DNA binding site [nucleotide binding] 246196007967 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196007968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007969 NAD(P) binding site [chemical binding]; other site 246196007970 active site 246196007971 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 246196007972 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 246196007973 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 246196007974 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196007975 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196007976 active site 246196007977 catalytic tetrad [active] 246196007978 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 246196007979 dimer interface [polypeptide binding]; other site 246196007980 FMN binding site [chemical binding]; other site 246196007981 NADPH bind site [chemical binding]; other site 246196007982 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196007983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007984 NAD(P) binding site [chemical binding]; other site 246196007985 active site 246196007986 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 246196007987 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 246196007988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007989 dimer interface [polypeptide binding]; other site 246196007990 ABC-ATPase subunit interface; other site 246196007991 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 246196007992 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 246196007993 Walker A/P-loop; other site 246196007994 ATP binding site [chemical binding]; other site 246196007995 Q-loop/lid; other site 246196007996 ABC transporter signature motif; other site 246196007997 Walker B; other site 246196007998 D-loop; other site 246196007999 H-loop/switch region; other site 246196008000 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 246196008001 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 246196008002 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196008003 CoenzymeA binding site [chemical binding]; other site 246196008004 subunit interaction site [polypeptide binding]; other site 246196008005 PHB binding site; other site 246196008006 TIGR02611 family protein; Region: TIGR02611 246196008007 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 246196008008 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 246196008009 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 246196008010 active site 246196008011 dimer interface [polypeptide binding]; other site 246196008012 motif 1; other site 246196008013 motif 2; other site 246196008014 motif 3; other site 246196008015 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 246196008016 anticodon binding site; other site 246196008017 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 246196008018 nucleotide binding site/active site [active] 246196008019 HIT family signature motif; other site 246196008020 catalytic residue [active] 246196008021 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 246196008022 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 246196008023 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 246196008024 putative acyl-acceptor binding pocket; other site 246196008025 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196008026 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196008027 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 246196008028 nudix motif; other site 246196008029 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 246196008030 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 246196008031 active site 246196008032 multimer interface [polypeptide binding]; other site 246196008033 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 246196008034 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196008035 active site 246196008036 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196008037 catalytic triad [active] 246196008038 dimer interface [polypeptide binding]; other site 246196008039 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 246196008040 predicted active site [active] 246196008041 catalytic triad [active] 246196008042 hypothetical protein; Validated; Region: PRK00110 246196008043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196008044 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196008045 NAD(P) binding site [chemical binding]; other site 246196008046 active site 246196008047 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 246196008048 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196008049 putative metal binding site [ion binding]; other site 246196008050 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 246196008051 active site 246196008052 putative DNA-binding cleft [nucleotide binding]; other site 246196008053 dimer interface [polypeptide binding]; other site 246196008054 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 246196008055 RuvA N terminal domain; Region: RuvA_N; pfam01330 246196008056 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 246196008057 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 246196008058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196008059 Walker A motif; other site 246196008060 ATP binding site [chemical binding]; other site 246196008061 Walker B motif; other site 246196008062 arginine finger; other site 246196008063 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 246196008064 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 246196008065 Putative cyclase; Region: Cyclase; pfam04199 246196008066 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196008067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196008068 substrate binding site [chemical binding]; other site 246196008069 oxyanion hole (OAH) forming residues; other site 246196008070 trimer interface [polypeptide binding]; other site 246196008071 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196008072 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196008073 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196008074 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196008075 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196008076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196008077 catalytic loop [active] 246196008078 iron binding site [ion binding]; other site 246196008079 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196008080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008081 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196008082 putative substrate translocation pore; other site 246196008083 EthD domain; Region: EthD; cl17553 246196008084 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196008085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196008086 DNA binding site [nucleotide binding] 246196008087 domain linker motif; other site 246196008088 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196008089 ligand binding site [chemical binding]; other site 246196008090 dimerization interface [polypeptide binding]; other site 246196008091 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196008092 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246196008093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196008094 acyl-activating enzyme (AAE) consensus motif; other site 246196008095 AMP binding site [chemical binding]; other site 246196008096 active site 246196008097 CoA binding site [chemical binding]; other site 246196008098 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196008099 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196008100 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246196008101 putative NAD(P) binding site [chemical binding]; other site 246196008102 active site 246196008103 putative substrate binding site [chemical binding]; other site 246196008104 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196008105 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 246196008106 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196008107 inhibitor-cofactor binding pocket; inhibition site 246196008108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008109 catalytic residue [active] 246196008110 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 246196008111 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 246196008112 Protein export membrane protein; Region: SecD_SecF; cl14618 246196008113 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 246196008114 Protein export membrane protein; Region: SecD_SecF; pfam02355 246196008115 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 246196008116 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 246196008117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196008118 active site 246196008119 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 246196008120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196008121 Zn2+ binding site [ion binding]; other site 246196008122 Mg2+ binding site [ion binding]; other site 246196008123 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 246196008124 synthetase active site [active] 246196008125 NTP binding site [chemical binding]; other site 246196008126 metal binding site [ion binding]; metal-binding site 246196008127 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 246196008128 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 246196008129 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 246196008130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008132 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 246196008133 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 246196008134 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 246196008135 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 246196008136 active site 246196008137 FMN binding site [chemical binding]; other site 246196008138 substrate binding site [chemical binding]; other site 246196008139 putative catalytic residue [active] 246196008140 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 246196008141 active site 246196008142 catalytic site [active] 246196008143 Zn binding site [ion binding]; other site 246196008144 tetramer interface [polypeptide binding]; other site 246196008145 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196008146 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196008147 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196008148 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 246196008149 Na binding site [ion binding]; other site 246196008150 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 246196008151 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246196008152 active site 246196008153 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246196008154 active site 246196008155 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 246196008156 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 246196008157 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 246196008158 dimer interface [polypeptide binding]; other site 246196008159 motif 1; other site 246196008160 active site 246196008161 motif 2; other site 246196008162 motif 3; other site 246196008163 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 246196008164 anticodon binding site; other site 246196008165 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 246196008166 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246196008167 Walker A/P-loop; other site 246196008168 ATP binding site [chemical binding]; other site 246196008169 Q-loop/lid; other site 246196008170 ABC transporter signature motif; other site 246196008171 Walker B; other site 246196008172 D-loop; other site 246196008173 H-loop/switch region; other site 246196008174 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 246196008175 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246196008176 Walker A/P-loop; other site 246196008177 ATP binding site [chemical binding]; other site 246196008178 Q-loop/lid; other site 246196008179 ABC transporter signature motif; other site 246196008180 Walker B; other site 246196008181 D-loop; other site 246196008182 H-loop/switch region; other site 246196008183 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 246196008184 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246196008185 TM-ABC transporter signature motif; other site 246196008186 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246196008187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196008188 TM-ABC transporter signature motif; other site 246196008189 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 246196008190 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 246196008191 putative ligand binding site [chemical binding]; other site 246196008192 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196008193 catalytic site [active] 246196008194 fumarate hydratase; Provisional; Region: PRK15389 246196008195 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 246196008196 Fumarase C-terminus; Region: Fumerase_C; pfam05683 246196008197 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196008198 Amidase; Region: Amidase; pfam01425 246196008199 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196008200 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 246196008201 putative active site [active] 246196008202 catalytic triad [active] 246196008203 putative dimer interface [polypeptide binding]; other site 246196008204 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196008205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196008206 DNA binding site [nucleotide binding] 246196008207 domain linker motif; other site 246196008208 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 246196008209 putative dimerization interface [polypeptide binding]; other site 246196008210 putative ligand binding site [chemical binding]; other site 246196008211 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 246196008212 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 246196008213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008214 putative substrate translocation pore; other site 246196008215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196008216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196008217 active site 246196008218 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196008219 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196008220 active site 246196008221 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196008222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196008223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008224 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196008225 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196008226 acyl-CoA thioesterase II; Region: tesB; TIGR00189 246196008227 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196008228 active site 246196008229 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196008230 catalytic triad [active] 246196008231 dimer interface [polypeptide binding]; other site 246196008232 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196008233 DinB superfamily; Region: DinB_2; pfam12867 246196008234 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 246196008235 Predicted metalloprotease [General function prediction only]; Region: COG2321 246196008236 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 246196008237 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 246196008238 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196008239 substrate binding pocket [chemical binding]; other site 246196008240 catalytic triad [active] 246196008241 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 246196008242 putative hydrophobic ligand binding site [chemical binding]; other site 246196008243 protein interface [polypeptide binding]; other site 246196008244 gate; other site 246196008245 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 246196008246 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 246196008247 dimer interface [polypeptide binding]; other site 246196008248 anticodon binding site; other site 246196008249 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 246196008250 homodimer interface [polypeptide binding]; other site 246196008251 motif 1; other site 246196008252 active site 246196008253 motif 2; other site 246196008254 GAD domain; Region: GAD; pfam02938 246196008255 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246196008256 active site 246196008257 motif 3; other site 246196008258 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196008259 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 246196008260 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196008261 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196008262 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 246196008263 6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191 246196008264 putative active site [active] 246196008265 metal binding site [ion binding]; metal-binding site 246196008266 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196008267 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 246196008268 tetramerization interface [polypeptide binding]; other site 246196008269 NAD(P) binding site [chemical binding]; other site 246196008270 catalytic residues [active] 246196008271 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246196008272 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196008273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196008274 NAD(P) binding site [chemical binding]; other site 246196008275 active site 246196008276 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 246196008277 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196008278 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196008279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196008280 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 246196008281 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196008282 dimer interface [polypeptide binding]; other site 246196008283 active site 246196008284 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196008285 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196008286 Protein of unknown function (DUF419); Region: DUF419; cl15265 246196008287 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196008288 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246196008289 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 246196008290 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246196008291 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 246196008292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 246196008293 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 246196008294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 246196008295 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 246196008296 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246196008297 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 246196008298 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246196008299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 246196008300 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 246196008301 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 246196008302 recombination factor protein RarA; Reviewed; Region: PRK13342 246196008303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196008304 Walker A motif; other site 246196008305 ATP binding site [chemical binding]; other site 246196008306 Walker B motif; other site 246196008307 arginine finger; other site 246196008308 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 246196008309 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 246196008310 Uncharacterized conserved protein [Function unknown]; Region: COG0432 246196008311 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 246196008312 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 246196008313 motif 1; other site 246196008314 active site 246196008315 motif 2; other site 246196008316 motif 3; other site 246196008317 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 246196008318 DHHA1 domain; Region: DHHA1; pfam02272 246196008319 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 246196008320 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 246196008321 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 246196008322 dimerization interface [polypeptide binding]; other site 246196008323 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 246196008324 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 246196008325 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 246196008326 NAD(P) binding site [chemical binding]; other site 246196008327 shikimate binding site; other site 246196008328 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 246196008329 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 246196008330 Tetramer interface [polypeptide binding]; other site 246196008331 active site 246196008332 FMN-binding site [chemical binding]; other site 246196008333 shikimate kinase; Reviewed; Region: aroK; PRK00131 246196008334 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 246196008335 ADP binding site [chemical binding]; other site 246196008336 magnesium binding site [ion binding]; other site 246196008337 putative shikimate binding site; other site 246196008338 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 246196008339 active site 246196008340 dimer interface [polypeptide binding]; other site 246196008341 metal binding site [ion binding]; metal-binding site 246196008342 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196008343 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196008344 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 246196008345 active site 246196008346 elongation factor P; Validated; Region: PRK00529 246196008347 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 246196008348 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 246196008349 RNA binding site [nucleotide binding]; other site 246196008350 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 246196008351 RNA binding site [nucleotide binding]; other site 246196008352 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 246196008353 putative RNA binding site [nucleotide binding]; other site 246196008354 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196008355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196008356 DNA binding residues [nucleotide binding] 246196008357 dimerization interface [polypeptide binding]; other site 246196008358 hypothetical protein; Provisional; Region: PRK07236 246196008359 hypothetical protein; Provisional; Region: PRK07588 246196008360 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196008361 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196008362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196008363 S-adenosylmethionine binding site [chemical binding]; other site 246196008364 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 246196008365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196008366 active site 246196008367 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 246196008368 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 246196008369 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 246196008370 dihydroorotase; Validated; Region: pyrC; PRK09357 246196008371 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196008372 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 246196008373 active site 246196008374 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 246196008375 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 246196008376 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 246196008377 catalytic site [active] 246196008378 subunit interface [polypeptide binding]; other site 246196008379 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 246196008380 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196008381 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196008382 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 246196008383 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196008384 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196008385 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 246196008386 IMP binding site; other site 246196008387 dimer interface [polypeptide binding]; other site 246196008388 interdomain contacts; other site 246196008389 partial ornithine binding site; other site 246196008390 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 246196008391 active site 246196008392 dimer interface [polypeptide binding]; other site 246196008393 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 246196008394 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 246196008395 catalytic site [active] 246196008396 G-X2-G-X-G-K; other site 246196008397 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 246196008398 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 246196008399 Flavoprotein; Region: Flavoprotein; pfam02441 246196008400 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 246196008401 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 246196008402 S-adenosylmethionine synthetase; Validated; Region: PRK05250 246196008403 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 246196008404 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 246196008405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196008406 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 246196008407 Walker A/P-loop; other site 246196008408 ATP binding site [chemical binding]; other site 246196008409 Q-loop/lid; other site 246196008410 ABC transporter signature motif; other site 246196008411 Walker B; other site 246196008412 D-loop; other site 246196008413 H-loop/switch region; other site 246196008414 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 246196008415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008416 dimer interface [polypeptide binding]; other site 246196008417 conserved gate region; other site 246196008418 ABC-ATPase subunit interface; other site 246196008419 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 246196008420 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 246196008421 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196008422 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196008423 substrate binding pocket [chemical binding]; other site 246196008424 YhhN-like protein; Region: YhhN; pfam07947 246196008425 primosome assembly protein PriA; Provisional; Region: PRK14873 246196008426 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 246196008427 LemA family; Region: LemA; cl00742 246196008428 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 246196008429 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 246196008430 putative active site [active] 246196008431 substrate binding site [chemical binding]; other site 246196008432 putative cosubstrate binding site; other site 246196008433 catalytic site [active] 246196008434 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 246196008435 substrate binding site [chemical binding]; other site 246196008436 16S rRNA methyltransferase B; Provisional; Region: PRK14902 246196008437 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 246196008438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196008439 S-adenosylmethionine binding site [chemical binding]; other site 246196008440 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 246196008441 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 246196008442 substrate binding site [chemical binding]; other site 246196008443 hexamer interface [polypeptide binding]; other site 246196008444 metal binding site [ion binding]; metal-binding site 246196008445 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 246196008446 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 246196008447 catalytic motif [active] 246196008448 Zn binding site [ion binding]; other site 246196008449 RibD C-terminal domain; Region: RibD_C; pfam01872 246196008450 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196008451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008452 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 246196008453 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 246196008454 Lumazine binding domain; Region: Lum_binding; pfam00677 246196008455 Lumazine binding domain; Region: Lum_binding; pfam00677 246196008456 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 246196008457 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 246196008458 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 246196008459 dimerization interface [polypeptide binding]; other site 246196008460 active site 246196008461 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 246196008462 homopentamer interface [polypeptide binding]; other site 246196008463 active site 246196008464 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 246196008465 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246196008466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196008467 Coenzyme A binding pocket [chemical binding]; other site 246196008468 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 246196008469 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 246196008470 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 246196008471 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 246196008472 GIY-YIG motif/motif A; other site 246196008473 active site 246196008474 catalytic site [active] 246196008475 putative DNA binding site [nucleotide binding]; other site 246196008476 metal binding site [ion binding]; metal-binding site 246196008477 UvrB/uvrC motif; Region: UVR; pfam02151 246196008478 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 246196008479 minor groove reading motif; other site 246196008480 Helix-hairpin-helix motif; Region: HHH; pfam00633 246196008481 helix-hairpin-helix signature motif; other site 246196008482 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 246196008483 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 246196008484 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 246196008485 phosphate binding site [ion binding]; other site 246196008486 putative substrate binding pocket [chemical binding]; other site 246196008487 dimer interface [polypeptide binding]; other site 246196008488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 246196008489 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 246196008490 SOUL heme-binding protein; Region: SOUL; pfam04832 246196008491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196008492 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 246196008493 NAD(P) binding site [chemical binding]; other site 246196008494 active site 246196008495 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 246196008496 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 246196008497 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 246196008498 Phosphoglycerate kinase; Region: PGK; pfam00162 246196008499 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 246196008500 substrate binding site [chemical binding]; other site 246196008501 hinge regions; other site 246196008502 ADP binding site [chemical binding]; other site 246196008503 catalytic site [active] 246196008504 triosephosphate isomerase; Provisional; Region: PRK14567 246196008505 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 246196008506 substrate binding site [chemical binding]; other site 246196008507 dimer interface [polypeptide binding]; other site 246196008508 catalytic triad [active] 246196008509 potential frameshift: common BLAST hit: gi|375140365|ref|YP_005001014.1| O-methyltransferase 246196008510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196008511 S-adenosylmethionine binding site [chemical binding]; other site 246196008512 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 246196008513 intersubunit interface [polypeptide binding]; other site 246196008514 active site 246196008515 catalytic residue [active] 246196008516 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196008517 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196008518 TM-ABC transporter signature motif; other site 246196008519 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196008520 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196008521 Walker A/P-loop; other site 246196008522 ATP binding site [chemical binding]; other site 246196008523 Q-loop/lid; other site 246196008524 ABC transporter signature motif; other site 246196008525 Walker B; other site 246196008526 D-loop; other site 246196008527 H-loop/switch region; other site 246196008528 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196008529 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196008530 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196008531 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 246196008532 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 246196008533 N- and C-terminal domain interface [polypeptide binding]; other site 246196008534 active site 246196008535 MgATP binding site [chemical binding]; other site 246196008536 catalytic site [active] 246196008537 metal binding site [ion binding]; metal-binding site 246196008538 putative carbohydrate binding site [chemical binding]; other site 246196008539 putative homodimer interface [polypeptide binding]; other site 246196008540 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 246196008541 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 246196008542 putative NAD(P) binding site [chemical binding]; other site 246196008543 catalytic Zn binding site [ion binding]; other site 246196008544 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196008545 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 246196008546 putative ligand binding site [chemical binding]; other site 246196008547 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 246196008548 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 246196008549 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 246196008550 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 246196008551 putative active site [active] 246196008552 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 246196008553 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 246196008554 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 246196008555 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 246196008556 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 246196008557 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 246196008558 putative active site [active] 246196008559 transaldolase; Provisional; Region: PRK03903 246196008560 catalytic residue [active] 246196008561 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 246196008562 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 246196008563 TPP-binding site [chemical binding]; other site 246196008564 dimer interface [polypeptide binding]; other site 246196008565 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246196008566 PYR/PP interface [polypeptide binding]; other site 246196008567 dimer interface [polypeptide binding]; other site 246196008568 TPP binding site [chemical binding]; other site 246196008569 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196008570 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 246196008571 UbiA prenyltransferase family; Region: UbiA; pfam01040 246196008572 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 246196008573 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 246196008574 NADP binding site [chemical binding]; other site 246196008575 dimer interface [polypeptide binding]; other site 246196008576 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 246196008577 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196008578 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196008579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196008580 Walker A/P-loop; other site 246196008581 ATP binding site [chemical binding]; other site 246196008582 Q-loop/lid; other site 246196008583 ABC transporter signature motif; other site 246196008584 Walker B; other site 246196008585 D-loop; other site 246196008586 H-loop/switch region; other site 246196008587 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196008588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008589 dimer interface [polypeptide binding]; other site 246196008590 conserved gate region; other site 246196008591 putative PBP binding loops; other site 246196008592 ABC-ATPase subunit interface; other site 246196008593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008594 dimer interface [polypeptide binding]; other site 246196008595 conserved gate region; other site 246196008596 putative PBP binding loops; other site 246196008597 ABC-ATPase subunit interface; other site 246196008598 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196008599 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196008600 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196008601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196008602 NAD(P) binding site [chemical binding]; other site 246196008603 active site 246196008604 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 246196008605 N- and C-terminal domain interface [polypeptide binding]; other site 246196008606 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 246196008607 putative active site [active] 246196008608 MgATP binding site [chemical binding]; other site 246196008609 catalytic site [active] 246196008610 metal binding site [ion binding]; metal-binding site 246196008611 putative xylulose binding site [chemical binding]; other site 246196008612 putative homodimer interface [polypeptide binding]; other site 246196008613 BtpA family; Region: BtpA; cl00440 246196008614 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 246196008615 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 246196008616 active site 246196008617 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196008618 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 246196008619 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196008620 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 246196008621 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 246196008622 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246196008623 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196008624 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196008625 Walker A/P-loop; other site 246196008626 ATP binding site [chemical binding]; other site 246196008627 Q-loop/lid; other site 246196008628 ABC transporter signature motif; other site 246196008629 Walker B; other site 246196008630 D-loop; other site 246196008631 H-loop/switch region; other site 246196008632 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 246196008633 Predicted transcriptional regulator [Transcription]; Region: COG2345 246196008634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196008635 putative DNA binding site [nucleotide binding]; other site 246196008636 putative Zn2+ binding site [ion binding]; other site 246196008637 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 246196008638 FeS assembly protein SufB; Region: sufB; TIGR01980 246196008639 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 246196008640 FeS assembly protein SufD; Region: sufD; TIGR01981 246196008641 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 246196008642 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 246196008643 Walker A/P-loop; other site 246196008644 ATP binding site [chemical binding]; other site 246196008645 Q-loop/lid; other site 246196008646 ABC transporter signature motif; other site 246196008647 Walker B; other site 246196008648 D-loop; other site 246196008649 H-loop/switch region; other site 246196008650 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246196008651 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 246196008652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196008653 catalytic residue [active] 246196008654 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 246196008655 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 246196008656 trimerization site [polypeptide binding]; other site 246196008657 active site 246196008658 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 246196008659 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246196008660 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 246196008661 acyl-activating enzyme (AAE) consensus motif; other site 246196008662 putative AMP binding site [chemical binding]; other site 246196008663 putative active site [active] 246196008664 putative CoA binding site [chemical binding]; other site 246196008665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196008666 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196008667 salt bridge; other site 246196008668 non-specific DNA binding site [nucleotide binding]; other site 246196008669 sequence-specific DNA binding site [nucleotide binding]; other site 246196008670 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196008671 Cytochrome P450; Region: p450; cl12078 246196008672 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 246196008673 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 246196008674 putative active site [active] 246196008675 putative FMN binding site [chemical binding]; other site 246196008676 putative substrate binding site [chemical binding]; other site 246196008677 putative catalytic residue [active] 246196008678 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246196008679 catalytic residues [active] 246196008680 enoyl-CoA hydratase; Provisional; Region: PRK05864 246196008681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196008682 substrate binding site [chemical binding]; other site 246196008683 oxyanion hole (OAH) forming residues; other site 246196008684 trimer interface [polypeptide binding]; other site 246196008685 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246196008686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196008687 Walker A/P-loop; other site 246196008688 ATP binding site [chemical binding]; other site 246196008689 Q-loop/lid; other site 246196008690 ABC transporter signature motif; other site 246196008691 Walker B; other site 246196008692 D-loop; other site 246196008693 H-loop/switch region; other site 246196008694 ABC transporter; Region: ABC_tran_2; pfam12848 246196008695 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196008696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196008697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008698 aconitate hydratase; Validated; Region: PRK09277 246196008699 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246196008700 substrate binding site [chemical binding]; other site 246196008701 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246196008702 ligand binding site [chemical binding]; other site 246196008703 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 246196008704 substrate binding site [chemical binding]; other site 246196008705 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196008706 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196008707 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196008708 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196008709 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196008710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196008711 Walker A motif; other site 246196008712 ATP binding site [chemical binding]; other site 246196008713 Walker B motif; other site 246196008714 arginine finger; other site 246196008715 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246196008716 Protein of unknown function DUF58; Region: DUF58; pfam01882 246196008717 hypothetical protein; Provisional; Region: PRK13685 246196008718 von Willebrand factor type A domain; Region: VWA_2; pfam13519 246196008719 metal ion-dependent adhesion site (MIDAS); other site 246196008720 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 246196008721 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246196008722 NAD(P) binding site [chemical binding]; other site 246196008723 homotetramer interface [polypeptide binding]; other site 246196008724 homodimer interface [polypeptide binding]; other site 246196008725 active site 246196008726 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 246196008727 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 246196008728 NAD binding site [chemical binding]; other site 246196008729 homotetramer interface [polypeptide binding]; other site 246196008730 homodimer interface [polypeptide binding]; other site 246196008731 substrate binding site [chemical binding]; other site 246196008732 active site 246196008733 ferrochelatase; Reviewed; Region: hemH; PRK00035 246196008734 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 246196008735 C-terminal domain interface [polypeptide binding]; other site 246196008736 active site 246196008737 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 246196008738 active site 246196008739 N-terminal domain interface [polypeptide binding]; other site 246196008740 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 246196008741 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246196008742 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 246196008743 DoxX-like family; Region: DoxX_2; pfam13564 246196008744 Uncharacterized conserved protein [Function unknown]; Region: COG0398 246196008745 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 246196008746 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 246196008747 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 246196008748 heterodimer interface [polypeptide binding]; other site 246196008749 substrate interaction site [chemical binding]; other site 246196008750 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246196008751 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 246196008752 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 246196008753 active site 246196008754 substrate binding site [chemical binding]; other site 246196008755 coenzyme B12 binding site [chemical binding]; other site 246196008756 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 246196008757 B12 binding site [chemical binding]; other site 246196008758 cobalt ligand [ion binding]; other site 246196008759 membrane ATPase/protein kinase; Provisional; Region: PRK09435 246196008760 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 246196008761 Walker A; other site 246196008762 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 246196008763 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196008764 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196008765 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196008766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196008767 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196008768 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 246196008769 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 246196008770 HIGH motif; other site 246196008771 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 246196008772 active site 246196008773 KMSKS motif; other site 246196008774 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 246196008775 tRNA binding surface [nucleotide binding]; other site 246196008776 anticodon binding site; other site 246196008777 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196008778 RNA binding surface [nucleotide binding]; other site 246196008779 DNA polymerase IV; Provisional; Region: PRK03348 246196008780 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246196008781 active site 246196008782 DNA binding site [nucleotide binding] 246196008783 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 246196008784 active site 246196008785 homodimer interface [polypeptide binding]; other site 246196008786 homotetramer interface [polypeptide binding]; other site 246196008787 lipoprotein signal peptidase; Provisional; Region: PRK14764 246196008788 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 246196008789 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246196008790 active site 246196008791 Predicted permeases [General function prediction only]; Region: RarD; COG2962 246196008792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196008793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008794 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 246196008795 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 246196008796 active site 246196008797 PHP Thumb interface [polypeptide binding]; other site 246196008798 metal binding site [ion binding]; metal-binding site 246196008799 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 246196008800 generic binding surface II; other site 246196008801 generic binding surface I; other site 246196008802 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 246196008803 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 246196008804 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 246196008805 DNA binding residues [nucleotide binding] 246196008806 putative dimer interface [polypeptide binding]; other site 246196008807 putative metal binding residues [ion binding]; other site 246196008808 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 246196008809 threonine dehydratase; Validated; Region: PRK08639 246196008810 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 246196008811 tetramer interface [polypeptide binding]; other site 246196008812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008813 catalytic residue [active] 246196008814 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 246196008815 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 246196008816 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 246196008817 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 246196008818 catalytic site [active] 246196008819 active site 246196008820 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 246196008821 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 246196008822 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 246196008823 active site 246196008824 catalytic site [active] 246196008825 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 246196008826 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 246196008827 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 246196008828 active site 246196008829 catalytic site [active] 246196008830 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196008831 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 246196008832 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196008833 inhibitor-cofactor binding pocket; inhibition site 246196008834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008835 catalytic residue [active] 246196008836 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 246196008837 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 246196008838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196008839 catalytic residue [active] 246196008840 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 246196008841 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 246196008842 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196008843 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196008844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008845 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196008846 biotin synthase; Validated; Region: PRK06256 246196008847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196008848 FeS/SAM binding site; other site 246196008849 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 246196008850 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 246196008851 Secretory lipase; Region: LIP; pfam03583 246196008852 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 246196008853 nudix motif; other site 246196008854 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 246196008855 quinolinate synthetase; Provisional; Region: PRK09375 246196008856 L-aspartate oxidase; Provisional; Region: PRK07804 246196008857 L-aspartate oxidase; Provisional; Region: PRK06175 246196008858 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196008859 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 246196008860 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 246196008861 dimerization interface [polypeptide binding]; other site 246196008862 active site 246196008863 LysE type translocator; Region: LysE; cl00565 246196008864 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196008865 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 246196008866 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 246196008867 NAD binding site [chemical binding]; other site 246196008868 dimerization interface [polypeptide binding]; other site 246196008869 product binding site; other site 246196008870 substrate binding site [chemical binding]; other site 246196008871 zinc binding site [ion binding]; other site 246196008872 catalytic residues [active] 246196008873 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 246196008874 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196008875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008876 homodimer interface [polypeptide binding]; other site 246196008877 catalytic residue [active] 246196008878 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 246196008879 putative active site pocket [active] 246196008880 4-fold oligomerization interface [polypeptide binding]; other site 246196008881 metal binding residues [ion binding]; metal-binding site 246196008882 3-fold/trimer interface [polypeptide binding]; other site 246196008883 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 246196008884 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 246196008885 putative active site [active] 246196008886 oxyanion strand; other site 246196008887 catalytic triad [active] 246196008888 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 246196008889 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 246196008890 catalytic residues [active] 246196008891 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 246196008892 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 246196008893 active site 246196008894 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 246196008895 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 246196008896 substrate binding site [chemical binding]; other site 246196008897 glutamase interaction surface [polypeptide binding]; other site 246196008898 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 246196008899 Methyltransferase domain; Region: Methyltransf_26; pfam13659 246196008900 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196008901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196008902 Walker A/P-loop; other site 246196008903 ATP binding site [chemical binding]; other site 246196008904 Q-loop/lid; other site 246196008905 ABC transporter signature motif; other site 246196008906 Walker B; other site 246196008907 D-loop; other site 246196008908 H-loop/switch region; other site 246196008909 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246196008910 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 246196008911 catalytic triad [active] 246196008912 anthranilate synthase component I; Provisional; Region: PRK13571 246196008913 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 246196008914 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246196008915 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 246196008916 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 246196008917 active site 246196008918 ribulose/triose binding site [chemical binding]; other site 246196008919 phosphate binding site [ion binding]; other site 246196008920 substrate (anthranilate) binding pocket [chemical binding]; other site 246196008921 product (indole) binding pocket [chemical binding]; other site 246196008922 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 246196008923 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 246196008924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008925 catalytic residue [active] 246196008926 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 246196008927 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 246196008928 substrate binding site [chemical binding]; other site 246196008929 active site 246196008930 catalytic residues [active] 246196008931 heterodimer interface [polypeptide binding]; other site 246196008932 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 246196008933 TM2 domain; Region: TM2; pfam05154 246196008934 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 246196008935 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 246196008936 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 246196008937 active site 246196008938 dimer interface [polypeptide binding]; other site 246196008939 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 246196008940 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246196008941 active site 246196008942 FMN binding site [chemical binding]; other site 246196008943 substrate binding site [chemical binding]; other site 246196008944 3Fe-4S cluster binding site [ion binding]; other site 246196008945 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 246196008946 domain interface; other site 246196008947 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 246196008948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196008949 pyruvate kinase; Provisional; Region: PRK06247 246196008950 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 246196008951 domain interfaces; other site 246196008952 active site 246196008953 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 246196008954 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196008955 active site 246196008956 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196008957 catalytic triad [active] 246196008958 dimer interface [polypeptide binding]; other site 246196008959 Vta1 like; Region: DUF605; pfam04652 246196008960 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 246196008961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196008962 Walker A/P-loop; other site 246196008963 ATP binding site [chemical binding]; other site 246196008964 Q-loop/lid; other site 246196008965 ABC transporter signature motif; other site 246196008966 Walker B; other site 246196008967 D-loop; other site 246196008968 H-loop/switch region; other site 246196008969 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 246196008970 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 246196008971 Walker A/P-loop; other site 246196008972 ATP binding site [chemical binding]; other site 246196008973 Q-loop/lid; other site 246196008974 ABC transporter signature motif; other site 246196008975 Walker B; other site 246196008976 D-loop; other site 246196008977 H-loop/switch region; other site 246196008978 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 246196008979 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 246196008980 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 246196008981 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 246196008982 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196008983 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196008984 substrate binding pocket [chemical binding]; other site 246196008985 membrane-bound complex binding site; other site 246196008986 hinge residues; other site 246196008987 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246196008988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008989 dimer interface [polypeptide binding]; other site 246196008990 conserved gate region; other site 246196008991 putative PBP binding loops; other site 246196008992 ABC-ATPase subunit interface; other site 246196008993 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196008994 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196008995 Walker A/P-loop; other site 246196008996 ATP binding site [chemical binding]; other site 246196008997 Q-loop/lid; other site 246196008998 ABC transporter signature motif; other site 246196008999 Walker B; other site 246196009000 D-loop; other site 246196009001 H-loop/switch region; other site 246196009002 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 246196009003 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 246196009004 active site residue [active] 246196009005 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196009006 active site residue [active] 246196009007 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 246196009008 ATP binding site [chemical binding]; other site 246196009009 G-X-G motif; other site 246196009010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196009011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196009012 active site 246196009013 phosphorylation site [posttranslational modification] 246196009014 intermolecular recognition site; other site 246196009015 dimerization interface [polypeptide binding]; other site 246196009016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196009017 DNA binding residues [nucleotide binding] 246196009018 dimerization interface [polypeptide binding]; other site 246196009019 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 246196009020 Ferritin-like domain; Region: Ferritin; pfam00210 246196009021 dimerization interface [polypeptide binding]; other site 246196009022 DPS ferroxidase diiron center [ion binding]; other site 246196009023 ion pore; other site 246196009024 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 246196009025 cyclase homology domain; Region: CHD; cd07302 246196009026 nucleotidyl binding site; other site 246196009027 metal binding site [ion binding]; metal-binding site 246196009028 dimer interface [polypeptide binding]; other site 246196009029 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 246196009030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196009031 active site 246196009032 phosphorylation site [posttranslational modification] 246196009033 intermolecular recognition site; other site 246196009034 dimerization interface [polypeptide binding]; other site 246196009035 ANTAR domain; Region: ANTAR; pfam03861 246196009036 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 246196009037 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 246196009038 dimerization interface [polypeptide binding]; other site 246196009039 ligand binding site [chemical binding]; other site 246196009040 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196009041 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246196009042 TM-ABC transporter signature motif; other site 246196009043 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 246196009044 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246196009045 TM-ABC transporter signature motif; other site 246196009046 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196009047 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246196009048 Walker A/P-loop; other site 246196009049 ATP binding site [chemical binding]; other site 246196009050 Q-loop/lid; other site 246196009051 ABC transporter signature motif; other site 246196009052 Walker B; other site 246196009053 D-loop; other site 246196009054 H-loop/switch region; other site 246196009055 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246196009056 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246196009057 Walker A/P-loop; other site 246196009058 ATP binding site [chemical binding]; other site 246196009059 Q-loop/lid; other site 246196009060 ABC transporter signature motif; other site 246196009061 Walker B; other site 246196009062 D-loop; other site 246196009063 H-loop/switch region; other site 246196009064 hypothetical protein; Provisional; Region: PRK02237 246196009065 RDD family; Region: RDD; pfam06271 246196009066 Predicted membrane protein [Function unknown]; Region: COG2259 246196009067 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 246196009068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196009069 nucleotide binding site [chemical binding]; other site 246196009070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196009071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196009072 active site 246196009073 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 246196009074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196009075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196009076 dimerization interface [polypeptide binding]; other site 246196009077 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196009078 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 246196009079 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 246196009080 N- and C-terminal domain interface [polypeptide binding]; other site 246196009081 putative active site [active] 246196009082 MgATP binding site [chemical binding]; other site 246196009083 catalytic site [active] 246196009084 metal binding site [ion binding]; metal-binding site 246196009085 putative xylulose binding site [chemical binding]; other site 246196009086 putative homodimer interface [polypeptide binding]; other site 246196009087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009088 active site 246196009089 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196009090 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196009091 DNA binding residues [nucleotide binding] 246196009092 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196009093 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196009094 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196009095 NAD(P) binding site [chemical binding]; other site 246196009096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196009097 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 246196009098 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196009099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009100 dimer interface [polypeptide binding]; other site 246196009101 conserved gate region; other site 246196009102 putative PBP binding loops; other site 246196009103 ABC-ATPase subunit interface; other site 246196009104 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196009105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009106 dimer interface [polypeptide binding]; other site 246196009107 conserved gate region; other site 246196009108 putative PBP binding loops; other site 246196009109 ABC-ATPase subunit interface; other site 246196009110 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 246196009111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196009112 Walker A/P-loop; other site 246196009113 ATP binding site [chemical binding]; other site 246196009114 Q-loop/lid; other site 246196009115 ABC transporter signature motif; other site 246196009116 Walker B; other site 246196009117 D-loop; other site 246196009118 H-loop/switch region; other site 246196009119 TOBE domain; Region: TOBE_2; pfam08402 246196009120 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 246196009121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196009122 Walker A/P-loop; other site 246196009123 ATP binding site [chemical binding]; other site 246196009124 Q-loop/lid; other site 246196009125 ABC transporter signature motif; other site 246196009126 Walker B; other site 246196009127 D-loop; other site 246196009128 H-loop/switch region; other site 246196009129 dihydroxyacetone kinase; Provisional; Region: PRK14479 246196009130 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 246196009131 DAK2 domain; Region: Dak2; pfam02734 246196009132 ribose 5-phosphate isomerase; Region: RPI_actino; TIGR02133 246196009133 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 246196009134 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 246196009135 metal binding site [ion binding]; metal-binding site 246196009136 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 246196009137 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196009138 DNA binding residues [nucleotide binding] 246196009139 drug binding residues [chemical binding]; other site 246196009140 dimer interface [polypeptide binding]; other site 246196009141 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 246196009142 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196009143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009144 dimer interface [polypeptide binding]; other site 246196009145 conserved gate region; other site 246196009146 putative PBP binding loops; other site 246196009147 ABC-ATPase subunit interface; other site 246196009148 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196009149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009150 dimer interface [polypeptide binding]; other site 246196009151 conserved gate region; other site 246196009152 putative PBP binding loops; other site 246196009153 ABC-ATPase subunit interface; other site 246196009154 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 246196009155 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246196009156 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196009157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196009158 Walker A/P-loop; other site 246196009159 ATP binding site [chemical binding]; other site 246196009160 Q-loop/lid; other site 246196009161 ABC transporter signature motif; other site 246196009162 Walker B; other site 246196009163 D-loop; other site 246196009164 H-loop/switch region; other site 246196009165 TOBE domain; Region: TOBE_2; pfam08402 246196009166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009168 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196009169 MarR family; Region: MarR_2; pfam12802 246196009170 tartrate dehydrogenase; Provisional; Region: PRK08194 246196009171 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 246196009172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196009173 S-adenosylmethionine binding site [chemical binding]; other site 246196009174 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196009175 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 246196009176 nucleophilic elbow; other site 246196009177 catalytic triad; other site 246196009178 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196009179 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246196009180 AAA ATPase domain; Region: AAA_16; pfam13191 246196009181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196009182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196009183 DNA binding residues [nucleotide binding] 246196009184 dimerization interface [polypeptide binding]; other site 246196009185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196009186 salt bridge; other site 246196009187 non-specific DNA binding site [nucleotide binding]; other site 246196009188 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196009189 sequence-specific DNA binding site [nucleotide binding]; other site 246196009190 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 246196009191 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196009192 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196009193 DNA binding residues [nucleotide binding] 246196009194 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 246196009195 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246196009196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 246196009197 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196009198 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196009199 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196009200 putative NAD(P) binding site [chemical binding]; other site 246196009201 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196009202 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196009203 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196009204 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196009205 short chain dehydrogenase; Provisional; Region: PRK06180 246196009206 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196009207 NADP binding site [chemical binding]; other site 246196009208 active site 246196009209 steroid binding site; other site 246196009210 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 246196009211 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196009212 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 246196009213 NAD(P) binding site [chemical binding]; other site 246196009214 catalytic residues [active] 246196009215 EamA-like transporter family; Region: EamA; pfam00892 246196009216 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 246196009217 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 246196009218 NAD(P) binding site [chemical binding]; other site 246196009219 potential frameshift: common BLAST hit: gi|120401452|ref|YP_951281.1| NAD-dependent epimerase/dehydratase 246196009220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009221 active site 246196009222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009223 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196009224 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196009225 Ligand Binding Site [chemical binding]; other site 246196009226 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 246196009227 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 246196009228 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196009229 catalytic residue [active] 246196009230 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 246196009231 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 246196009232 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 246196009233 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196009234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196009235 nucleotide binding site [chemical binding]; other site 246196009236 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196009237 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196009238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 246196009239 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196009240 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196009241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009242 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196009243 hypothetical protein; Provisional; Region: PRK07588 246196009244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196009247 dimerization interface [polypeptide binding]; other site 246196009248 Bacterial TniB protein; Region: TniB; pfam05621 246196009249 AAA domain; Region: AAA_22; pfam13401 246196009250 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 246196009251 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 246196009252 CsbD-like; Region: CsbD; pfam05532 246196009253 tetracycline repressor protein TetR; Provisional; Region: PRK13756 246196009254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009255 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196009256 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246196009257 putative di-iron ligands [ion binding]; other site 246196009258 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196009259 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246196009260 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196009261 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196009262 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196009263 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196009264 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196009265 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 246196009266 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 246196009267 active site 246196009268 FMN binding site [chemical binding]; other site 246196009269 substrate binding site [chemical binding]; other site 246196009270 homotetramer interface [polypeptide binding]; other site 246196009271 catalytic residue [active] 246196009272 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196009273 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196009274 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 246196009275 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196009276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196009277 DNA-binding site [nucleotide binding]; DNA binding site 246196009278 FCD domain; Region: FCD; pfam07729 246196009279 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 246196009280 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196009281 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 246196009282 putative active site [active] 246196009283 catalytic triad [active] 246196009284 putative dimer interface [polypeptide binding]; other site 246196009285 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 246196009286 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 246196009287 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 246196009288 DctM-like transporters; Region: DctM; pfam06808 246196009289 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 246196009290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009292 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196009293 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 246196009294 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196009295 NADP binding site [chemical binding]; other site 246196009296 active site 246196009297 regulatory binding site [polypeptide binding]; other site 246196009298 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196009299 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 246196009300 YaeQ protein; Region: YaeQ; pfam07152 246196009301 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 246196009302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009304 enoyl-CoA hydratase; Provisional; Region: PRK06563 246196009305 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196009306 substrate binding site [chemical binding]; other site 246196009307 oxyanion hole (OAH) forming residues; other site 246196009308 trimer interface [polypeptide binding]; other site 246196009309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009311 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 246196009312 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246196009313 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196009314 conserved cys residue [active] 246196009315 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 246196009316 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 246196009317 conserved cys residue [active] 246196009318 short chain dehydrogenase; Provisional; Region: PRK06500 246196009319 classical (c) SDRs; Region: SDR_c; cd05233 246196009320 NAD(P) binding site [chemical binding]; other site 246196009321 active site 246196009322 benzoate transport; Region: 2A0115; TIGR00895 246196009323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009324 putative substrate translocation pore; other site 246196009325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009326 classical (c) SDRs; Region: SDR_c; cd05233 246196009327 NAD(P) binding site [chemical binding]; other site 246196009328 active site 246196009329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009330 dimerization interface [polypeptide binding]; other site 246196009331 putative DNA binding site [nucleotide binding]; other site 246196009332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009334 putative substrate translocation pore; other site 246196009335 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 246196009336 choline dehydrogenase; Validated; Region: PRK02106 246196009337 lycopene cyclase; Region: lycopene_cycl; TIGR01789 246196009338 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196009339 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196009340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009341 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196009342 NAD(P) binding site [chemical binding]; other site 246196009343 active site 246196009344 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196009345 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196009346 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196009347 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 246196009348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009349 dimerization interface [polypeptide binding]; other site 246196009350 putative DNA binding site [nucleotide binding]; other site 246196009351 putative Zn2+ binding site [ion binding]; other site 246196009352 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 246196009353 NmrA-like family; Region: NmrA; pfam05368 246196009354 NAD(P) binding site [chemical binding]; other site 246196009355 active site lysine 246196009356 SnoaL-like domain; Region: SnoaL_3; pfam13474 246196009357 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196009358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009359 putative substrate translocation pore; other site 246196009360 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 246196009361 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196009362 NAD binding site [chemical binding]; other site 246196009363 catalytic residues [active] 246196009364 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 246196009365 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196009366 NAD binding site [chemical binding]; other site 246196009367 catalytic Zn binding site [ion binding]; other site 246196009368 substrate binding site [chemical binding]; other site 246196009369 structural Zn binding site [ion binding]; other site 246196009370 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 246196009371 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196009372 PYR/PP interface [polypeptide binding]; other site 246196009373 dimer interface [polypeptide binding]; other site 246196009374 TPP binding site [chemical binding]; other site 246196009375 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196009376 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 246196009377 TPP-binding site [chemical binding]; other site 246196009378 enoyl-CoA hydratase; Provisional; Region: PRK09245 246196009379 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196009380 substrate binding site [chemical binding]; other site 246196009381 oxyanion hole (OAH) forming residues; other site 246196009382 trimer interface [polypeptide binding]; other site 246196009383 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196009384 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196009385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196009386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196009387 active site 246196009388 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196009389 Cupin domain; Region: Cupin_2; cl17218 246196009390 short chain dehydrogenase; Provisional; Region: PRK06125 246196009391 classical (c) SDRs; Region: SDR_c; cd05233 246196009392 NAD(P) binding site [chemical binding]; other site 246196009393 active site 246196009394 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196009395 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196009396 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196009397 acetylornithine deacetylase; Provisional; Region: PRK06837 246196009398 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 246196009399 metal binding site [ion binding]; metal-binding site 246196009400 dimer interface [polypeptide binding]; other site 246196009401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009402 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196009403 putative substrate translocation pore; other site 246196009404 potential frameshift: common BLAST hit: gi|297561611|ref|YP_003680585.1| PucR family transcriptional regulator 246196009405 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196009406 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196009407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196009408 DNA-binding site [nucleotide binding]; DNA binding site 246196009409 FCD domain; Region: FCD; pfam07729 246196009410 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196009411 Amidase; Region: Amidase; pfam01425 246196009412 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 246196009413 putative active site [active] 246196009414 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196009415 Na binding site [ion binding]; other site 246196009416 formamidase; Provisional; Region: amiF; PRK13287 246196009417 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 246196009418 multimer interface [polypeptide binding]; other site 246196009419 active site 246196009420 catalytic triad [active] 246196009421 dimer interface [polypeptide binding]; other site 246196009422 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196009423 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196009424 active site 246196009425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009427 putative substrate translocation pore; other site 246196009428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009430 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196009431 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196009432 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196009433 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196009434 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 246196009435 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196009436 putative NAD(P) binding site [chemical binding]; other site 246196009437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009439 MOSC domain; Region: MOSC; pfam03473 246196009440 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 246196009441 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 246196009442 putative active site [active] 246196009443 putative catalytic site [active] 246196009444 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 246196009445 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196009446 DNA binding residues [nucleotide binding] 246196009447 putative dimer interface [polypeptide binding]; other site 246196009448 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196009449 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 246196009450 EamA-like transporter family; Region: EamA; cl17759 246196009451 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 246196009452 putative hydrophobic ligand binding site [chemical binding]; other site 246196009453 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 246196009454 hydrophobic ligand binding site; other site 246196009455 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 246196009456 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 246196009457 NADP binding site [chemical binding]; other site 246196009458 homodimer interface [polypeptide binding]; other site 246196009459 active site 246196009460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009461 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196009462 putative substrate translocation pore; other site 246196009463 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 246196009464 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 246196009465 NAD binding site [chemical binding]; other site 246196009466 ligand binding site [chemical binding]; other site 246196009467 catalytic site [active] 246196009468 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196009469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009470 putative DNA binding site [nucleotide binding]; other site 246196009471 putative Zn2+ binding site [ion binding]; other site 246196009472 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196009473 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196009474 Leucine carboxyl methyltransferase; Region: LCM; cl01306 246196009475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009477 short chain dehydrogenase; Provisional; Region: PRK06180 246196009478 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196009479 NADP binding site [chemical binding]; other site 246196009480 active site 246196009481 steroid binding site; other site 246196009482 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196009483 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196009484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196009485 S-adenosylmethionine binding site [chemical binding]; other site 246196009486 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196009487 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196009488 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 246196009489 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196009490 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246196009491 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 246196009492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 246196009493 AAA domain; Region: AAA_33; pfam13671 246196009494 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196009495 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246196009496 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 246196009497 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196009498 Predicted esterase [General function prediction only]; Region: COG0627 246196009499 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 246196009500 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 246196009501 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 246196009502 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 246196009503 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196009504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196009505 substrate binding pocket [chemical binding]; other site 246196009506 membrane-bound complex binding site; other site 246196009507 hinge residues; other site 246196009508 choline dehydrogenase; Validated; Region: PRK02106 246196009509 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196009510 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196009511 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 246196009512 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196009513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196009514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196009515 active site 246196009516 phosphorylation site [posttranslational modification] 246196009517 intermolecular recognition site; other site 246196009518 dimerization interface [polypeptide binding]; other site 246196009519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196009520 DNA binding residues [nucleotide binding] 246196009521 dimerization interface [polypeptide binding]; other site 246196009522 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196009523 GAF domain; Region: GAF; cl17456 246196009524 Histidine kinase; Region: HisKA_3; pfam07730 246196009525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196009526 ATP binding site [chemical binding]; other site 246196009527 G-X-G motif; other site 246196009528 RibD C-terminal domain; Region: RibD_C; cl17279 246196009529 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 246196009530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196009531 motif II; other site 246196009532 short chain dehydrogenase; Provisional; Region: PRK06482 246196009533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009534 NAD(P) binding site [chemical binding]; other site 246196009535 active site 246196009536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009538 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196009539 RNA binding surface [nucleotide binding]; other site 246196009540 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246196009541 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196009542 Uncharacterized conserved protein [Function unknown]; Region: COG2966 246196009543 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 246196009544 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 246196009545 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246196009546 metal binding site 2 [ion binding]; metal-binding site 246196009547 putative DNA binding helix; other site 246196009548 metal binding site 1 [ion binding]; metal-binding site 246196009549 dimer interface [polypeptide binding]; other site 246196009550 structural Zn2+ binding site [ion binding]; other site 246196009551 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 246196009552 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 246196009553 dimer interface [polypeptide binding]; other site 246196009554 active site 246196009555 heme binding site [chemical binding]; other site 246196009556 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 246196009557 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 246196009558 putative FMN binding site [chemical binding]; other site 246196009559 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 246196009560 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196009561 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196009562 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196009563 NAD(P) binding site [chemical binding]; other site 246196009564 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 246196009565 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196009566 acyl-activating enzyme (AAE) consensus motif; other site 246196009567 active site 246196009568 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196009569 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196009570 acyl-activating enzyme (AAE) consensus motif; other site 246196009571 AMP binding site [chemical binding]; other site 246196009572 active site 246196009573 CoA binding site [chemical binding]; other site 246196009574 YacP-like NYN domain; Region: NYN_YacP; cl01491 246196009575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009576 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 246196009577 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196009578 putative NAD(P) binding site [chemical binding]; other site 246196009579 hypothetical protein; Validated; Region: PRK07198 246196009580 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 246196009581 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 246196009582 dimerization interface [polypeptide binding]; other site 246196009583 active site 246196009584 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 246196009585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196009586 active site 246196009587 CAAX protease self-immunity; Region: Abi; pfam02517 246196009588 Peptidase family M48; Region: Peptidase_M48; pfam01435 246196009589 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196009590 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196009591 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 246196009592 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 246196009593 dimer interface [polypeptide binding]; other site 246196009594 catalytic triad [active] 246196009595 peroxidatic and resolving cysteines [active] 246196009596 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 246196009597 O-succinylbenzoate synthase; Provisional; Region: PRK02901 246196009598 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 246196009599 metal binding site [ion binding]; metal-binding site 246196009600 substrate binding pocket [chemical binding]; other site 246196009601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 246196009602 MOSC domain; Region: MOSC; pfam03473 246196009603 Cupin domain; Region: Cupin_2; pfam07883 246196009604 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 246196009605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196009606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196009607 DNA binding residues [nucleotide binding] 246196009608 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 246196009609 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 246196009610 tetramer interface [polypeptide binding]; other site 246196009611 heme binding pocket [chemical binding]; other site 246196009612 NADPH binding site [chemical binding]; other site 246196009613 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196009614 Zn2+ binding site [ion binding]; other site 246196009615 Mg2+ binding site [ion binding]; other site 246196009616 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246196009617 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196009618 conserved cys residue [active] 246196009619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196009620 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 246196009621 active site 246196009622 catalytic triad [active] 246196009623 oxyanion hole [active] 246196009624 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196009625 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 246196009626 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196009627 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 246196009628 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196009629 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196009630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009631 dimerization interface [polypeptide binding]; other site 246196009632 putative DNA binding site [nucleotide binding]; other site 246196009633 putative Zn2+ binding site [ion binding]; other site 246196009634 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 246196009635 putative hydrophobic ligand binding site [chemical binding]; other site 246196009636 NlpC/P60 family; Region: NLPC_P60; cl17555 246196009637 hypothetical protein; Validated; Region: PRK02101 246196009638 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196009639 Amidase; Region: Amidase; cl11426 246196009640 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 246196009641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196009642 catalytic residue [active] 246196009643 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 246196009644 catalytic residue [active] 246196009645 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196009646 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 246196009647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196009648 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196009649 Winged helix-turn helix; Region: HTH_29; pfam13551 246196009650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009651 putative DNA binding site [nucleotide binding]; other site 246196009652 dimerization interface [polypeptide binding]; other site 246196009653 putative Zn2+ binding site [ion binding]; other site 246196009654 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196009655 competence damage-inducible protein A; Provisional; Region: PRK00549 246196009656 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 246196009657 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 246196009658 hypothetical protein; Provisional; Region: PRK01346 246196009659 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 246196009660 Coenzyme A binding pocket [chemical binding]; other site 246196009661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009662 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196009663 NAD(P) binding site [chemical binding]; other site 246196009664 active site 246196009665 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196009666 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196009667 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246196009668 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 246196009669 Nitronate monooxygenase; Region: NMO; pfam03060 246196009670 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196009671 FMN binding site [chemical binding]; other site 246196009672 substrate binding site [chemical binding]; other site 246196009673 putative catalytic residue [active] 246196009674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009676 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246196009677 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196009678 molybdopterin cofactor binding site; other site 246196009679 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196009680 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 246196009681 molybdopterin cofactor binding site; other site 246196009682 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196009683 Cytochrome P450; Region: p450; cl12078 246196009684 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196009685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196009686 non-specific DNA binding site [nucleotide binding]; other site 246196009687 salt bridge; other site 246196009688 sequence-specific DNA binding site [nucleotide binding]; other site 246196009689 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 246196009690 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246196009691 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196009692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196009693 DNA-binding site [nucleotide binding]; DNA binding site 246196009694 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196009695 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 246196009696 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 246196009697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196009698 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196009699 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 246196009700 POT family; Region: PTR2; cl17359 246196009701 serine racemase; Region: PLN02970 246196009702 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 246196009703 tetramer interface [polypeptide binding]; other site 246196009704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196009705 catalytic residue [active] 246196009706 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246196009707 active site 246196009708 agmatinase; Region: agmatinase; TIGR01230 246196009709 Agmatinase-like family; Region: Agmatinase-like; cd09990 246196009710 active site 246196009711 oligomer interface [polypeptide binding]; other site 246196009712 Mn binding site [ion binding]; other site 246196009713 benzoate transport; Region: 2A0115; TIGR00895 246196009714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009715 putative substrate translocation pore; other site 246196009716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009717 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 246196009718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196009719 S-adenosylmethionine binding site [chemical binding]; other site 246196009720 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 246196009721 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 246196009722 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246196009723 catalytic residues [active] 246196009724 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 246196009725 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196009726 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 246196009727 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 246196009728 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196009729 membrane-bound complex binding site; other site 246196009730 hinge residues; other site 246196009731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009732 dimer interface [polypeptide binding]; other site 246196009733 conserved gate region; other site 246196009734 putative PBP binding loops; other site 246196009735 ABC-ATPase subunit interface; other site 246196009736 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246196009737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009738 dimer interface [polypeptide binding]; other site 246196009739 conserved gate region; other site 246196009740 putative PBP binding loops; other site 246196009741 ABC-ATPase subunit interface; other site 246196009742 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196009743 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196009744 Walker A/P-loop; other site 246196009745 ATP binding site [chemical binding]; other site 246196009746 Q-loop/lid; other site 246196009747 ABC transporter signature motif; other site 246196009748 Walker B; other site 246196009749 D-loop; other site 246196009750 H-loop/switch region; other site 246196009751 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196009752 Cytochrome P450; Region: p450; cl12078 246196009753 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196009754 phenylhydantoinase; Validated; Region: PRK08323 246196009755 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 246196009756 tetramer interface [polypeptide binding]; other site 246196009757 active site 246196009758 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196009759 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 246196009760 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 246196009761 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 246196009762 active site 246196009763 catalytic triad [active] 246196009764 dimer interface [polypeptide binding]; other site 246196009765 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 246196009766 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 246196009767 Na binding site [ion binding]; other site 246196009768 putative substrate binding site [chemical binding]; other site 246196009769 Amino acid permease; Region: AA_permease; pfam00324 246196009770 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246196009771 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196009772 short chain dehydrogenase; Provisional; Region: PRK08303 246196009773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009774 NAD(P) binding site [chemical binding]; other site 246196009775 active site 246196009776 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196009777 active site 246196009778 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196009779 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196009780 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196009781 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 246196009782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009783 putative substrate translocation pore; other site 246196009784 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 246196009785 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 246196009786 heme binding site [chemical binding]; other site 246196009787 ferroxidase pore; other site 246196009788 ferroxidase diiron center [ion binding]; other site 246196009789 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 246196009790 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196009791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196009792 substrate binding site [chemical binding]; other site 246196009793 oxyanion hole (OAH) forming residues; other site 246196009794 trimer interface [polypeptide binding]; other site 246196009795 EthD domain; Region: EthD; cl17553 246196009796 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246196009797 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196009798 CoenzymeA binding site [chemical binding]; other site 246196009799 subunit interaction site [polypeptide binding]; other site 246196009800 PHB binding site; other site 246196009801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009802 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 246196009803 TPR repeat; Region: TPR_11; pfam13414 246196009804 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246196009805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196009806 binding surface 246196009807 TPR motif; other site 246196009808 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246196009809 nucleoside/Zn binding site; other site 246196009810 dimer interface [polypeptide binding]; other site 246196009811 catalytic motif [active] 246196009812 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 246196009813 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 246196009814 active site 246196009815 catalytic site [active] 246196009816 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 246196009817 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196009818 dimerization interface [polypeptide binding]; other site 246196009819 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196009820 cyclase homology domain; Region: CHD; cd07302 246196009821 nucleotidyl binding site; other site 246196009822 metal binding site [ion binding]; metal-binding site 246196009823 dimer interface [polypeptide binding]; other site 246196009824 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246196009825 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246196009826 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196009827 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196009828 ligand binding site [chemical binding]; other site 246196009829 flexible hinge region; other site 246196009830 Putative esterase; Region: Esterase; pfam00756 246196009831 S-formylglutathione hydrolase; Region: PLN02442 246196009832 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196009833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009834 NAD(P) binding site [chemical binding]; other site 246196009835 active site 246196009836 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 246196009837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196009838 Walker A motif; other site 246196009839 ATP binding site [chemical binding]; other site 246196009840 Walker B motif; other site 246196009841 arginine finger; other site 246196009842 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246196009843 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 246196009844 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246196009845 Transport protein; Region: actII; TIGR00833 246196009846 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196009847 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196009848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009849 putative substrate translocation pore; other site 246196009850 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 246196009851 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 246196009852 Protein of unknown function DUF72; Region: DUF72; pfam01904 246196009853 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 246196009854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196009855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196009856 AAA ATPase domain; Region: AAA_16; pfam13191 246196009857 AAA domain; Region: AAA_22; pfam13401 246196009858 Domain of unknown function DUF87; Region: DUF87; pfam01935 246196009859 AAA-like domain; Region: AAA_10; pfam12846 246196009860 Zonular occludens toxin (Zot); Region: Zot; cl17485 246196009861 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 246196009862 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 246196009863 putative ligand binding site [chemical binding]; other site 246196009864 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196009865 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 246196009866 putative ligand binding site [chemical binding]; other site 246196009867 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196009868 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196009869 TM-ABC transporter signature motif; other site 246196009870 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196009871 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196009872 Walker A/P-loop; other site 246196009873 ATP binding site [chemical binding]; other site 246196009874 Q-loop/lid; other site 246196009875 ABC transporter signature motif; other site 246196009876 Walker B; other site 246196009877 D-loop; other site 246196009878 H-loop/switch region; other site 246196009879 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196009880 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196009881 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196009882 NAD(P) binding site [chemical binding]; other site 246196009883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009884 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196009885 NAD(P) binding site [chemical binding]; other site 246196009886 active site 246196009887 L-idonate 5-dehydrogenase; Region: PLN02702 246196009888 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 246196009889 inhibitor binding site; inhibition site 246196009890 catalytic Zn binding site [ion binding]; other site 246196009891 structural Zn binding site [ion binding]; other site 246196009892 NADP binding site [chemical binding]; other site 246196009893 tetramer interface [polypeptide binding]; other site 246196009894 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196009895 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246196009896 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196009897 short chain dehydrogenase; Provisional; Region: PRK06841 246196009898 classical (c) SDRs; Region: SDR_c; cd05233 246196009899 NAD(P) binding site [chemical binding]; other site 246196009900 active site 246196009901 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 246196009902 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196009903 active site 246196009904 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196009905 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196009906 putative phosphoketolase; Provisional; Region: PRK05261 246196009907 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 246196009908 TPP-binding site; other site 246196009909 XFP C-terminal domain; Region: XFP_C; pfam09363 246196009910 CAAX protease self-immunity; Region: Abi; pfam02517 246196009911 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 246196009912 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196009913 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196009914 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 246196009915 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 246196009916 putative NAD(P) binding site [chemical binding]; other site 246196009917 putative substrate binding site [chemical binding]; other site 246196009918 catalytic Zn binding site [ion binding]; other site 246196009919 structural Zn binding site [ion binding]; other site 246196009920 Predicted membrane protein [Function unknown]; Region: COG2261 246196009921 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 246196009922 classical (c) SDRs; Region: SDR_c; cd05233 246196009923 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196009924 NAD(P) binding site [chemical binding]; other site 246196009925 active site 246196009926 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196009927 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196009928 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246196009929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196009930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196009931 UreD urease accessory protein; Region: UreD; cl00530 246196009932 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196009933 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 246196009934 UreF; Region: UreF; pfam01730 246196009935 urease subunit alpha; Reviewed; Region: ureC; PRK13206 246196009936 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 246196009937 subunit interactions [polypeptide binding]; other site 246196009938 active site 246196009939 flap region; other site 246196009940 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 246196009941 gamma-beta subunit interface [polypeptide binding]; other site 246196009942 alpha-beta subunit interface [polypeptide binding]; other site 246196009943 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 246196009944 alpha-gamma subunit interface [polypeptide binding]; other site 246196009945 beta-gamma subunit interface [polypeptide binding]; other site 246196009946 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196009947 CoenzymeA binding site [chemical binding]; other site 246196009948 subunit interaction site [polypeptide binding]; other site 246196009949 PHB binding site; other site 246196009950 Predicted transcriptional regulator [Transcription]; Region: COG3682 246196009951 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 246196009952 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196009953 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 246196009954 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 246196009955 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 246196009956 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246196009957 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 246196009958 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 246196009959 active site 246196009960 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196009961 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 246196009962 Walker A/P-loop; other site 246196009963 ATP binding site [chemical binding]; other site 246196009964 Q-loop/lid; other site 246196009965 ABC transporter signature motif; other site 246196009966 Walker B; other site 246196009967 D-loop; other site 246196009968 H-loop/switch region; other site 246196009969 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 246196009970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009971 dimer interface [polypeptide binding]; other site 246196009972 conserved gate region; other site 246196009973 putative PBP binding loops; other site 246196009974 ABC-ATPase subunit interface; other site 246196009975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009976 dimer interface [polypeptide binding]; other site 246196009977 conserved gate region; other site 246196009978 putative PBP binding loops; other site 246196009979 ABC-ATPase subunit interface; other site 246196009980 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246196009981 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 246196009982 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246196009983 Domain of unknown function DUF21; Region: DUF21; pfam01595 246196009984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246196009985 Transporter associated domain; Region: CorC_HlyC; smart01091 246196009986 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246196009987 Domain of unknown function DUF21; Region: DUF21; pfam01595 246196009988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246196009989 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 246196009990 active site 246196009991 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246196009992 metal ion-dependent adhesion site (MIDAS); other site 246196009993 glycine dehydrogenase; Provisional; Region: PRK05367 246196009994 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 246196009995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196009996 tetramer interface [polypeptide binding]; other site 246196009997 catalytic residue [active] 246196009998 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 246196009999 tetramer interface [polypeptide binding]; other site 246196010000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196010001 catalytic residue [active] 246196010002 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 246196010003 DNA binding residues [nucleotide binding] 246196010004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196010005 putative dimer interface [polypeptide binding]; other site 246196010006 Bifunctional nuclease; Region: DNase-RNase; pfam02577 246196010007 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 246196010008 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196010009 DNA binding residues [nucleotide binding] 246196010010 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196010011 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196010012 phosphopeptide binding site; other site 246196010013 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 246196010014 lipoyl attachment site [posttranslational modification]; other site 246196010015 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 246196010016 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 246196010017 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 246196010018 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 246196010019 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 246196010020 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 246196010021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 246196010022 nucleotide binding region [chemical binding]; other site 246196010023 ATP-binding site [chemical binding]; other site 246196010024 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 246196010025 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 246196010026 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 246196010027 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 246196010028 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 246196010029 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 246196010030 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 246196010031 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196010032 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196010033 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 246196010034 substrate binding site [chemical binding]; other site 246196010035 dimer interface [polypeptide binding]; other site 246196010036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010038 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196010039 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 246196010040 dimerization interface [polypeptide binding]; other site 246196010041 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 246196010042 mannose binding site [chemical binding]; other site 246196010043 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196010044 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 246196010045 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196010046 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 246196010047 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 246196010048 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 246196010049 TrkA-C domain; Region: TrkA_C; pfam02080 246196010050 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246196010051 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246196010052 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196010053 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196010054 active site 246196010055 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 246196010056 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 246196010057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010058 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 246196010059 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 246196010060 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 246196010061 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 246196010062 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196010063 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196010064 FMN-binding pocket [chemical binding]; other site 246196010065 flavin binding motif; other site 246196010066 phosphate binding motif [ion binding]; other site 246196010067 beta-alpha-beta structure motif; other site 246196010068 NAD binding pocket [chemical binding]; other site 246196010069 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196010070 catalytic loop [active] 246196010071 iron binding site [ion binding]; other site 246196010072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196010073 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196010074 active site 246196010075 ATP binding site [chemical binding]; other site 246196010076 substrate binding site [chemical binding]; other site 246196010077 activation loop (A-loop); other site 246196010078 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246196010079 nudix motif; other site 246196010080 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 246196010081 active site 246196010082 catalytic triad [active] 246196010083 oxyanion hole [active] 246196010084 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196010085 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 246196010086 acyl-CoA synthetase; Validated; Region: PRK07798 246196010087 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196010088 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 246196010089 acyl-activating enzyme (AAE) consensus motif; other site 246196010090 acyl-activating enzyme (AAE) consensus motif; other site 246196010091 putative AMP binding site [chemical binding]; other site 246196010092 putative active site [active] 246196010093 putative CoA binding site [chemical binding]; other site 246196010094 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 246196010095 Na binding site [ion binding]; other site 246196010096 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196010097 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 246196010098 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 246196010099 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 246196010100 dimer interface [polypeptide binding]; other site 246196010101 active site 246196010102 galactokinase; Provisional; Region: PRK00555 246196010103 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 246196010104 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 246196010105 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196010106 Cytochrome P450; Region: p450; cl12078 246196010107 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196010108 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196010109 acyl-activating enzyme (AAE) consensus motif; other site 246196010110 putative AMP binding site [chemical binding]; other site 246196010111 putative active site [active] 246196010112 putative CoA binding site [chemical binding]; other site 246196010113 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196010114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196010115 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196010116 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 246196010117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010118 NAD(P) binding site [chemical binding]; other site 246196010119 active site 246196010120 D-galactonate transporter; Region: 2A0114; TIGR00893 246196010121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010122 putative substrate translocation pore; other site 246196010123 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196010124 tetramer interface [polypeptide binding]; other site 246196010125 active site 246196010126 Mg2+/Mn2+ binding site [ion binding]; other site 246196010127 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 246196010128 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 246196010129 putative heme binding pocket [chemical binding]; other site 246196010130 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 246196010131 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196010132 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246196010133 acyl-activating enzyme (AAE) consensus motif; other site 246196010134 AMP binding site [chemical binding]; other site 246196010135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196010136 Condensation domain; Region: Condensation; pfam00668 246196010137 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196010138 Condensation domain; Region: Condensation; pfam00668 246196010139 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196010140 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196010141 acyl-activating enzyme (AAE) consensus motif; other site 246196010142 AMP binding site [chemical binding]; other site 246196010143 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196010144 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196010145 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246196010146 putative NAD(P) binding site [chemical binding]; other site 246196010147 active site 246196010148 putative substrate binding site [chemical binding]; other site 246196010149 potential frameshift: common BLAST hit: gi|108798677|ref|YP_638874.1| short-chain dehydrogenase/reductase SDR 246196010150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010151 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196010152 classical (c) SDRs; Region: SDR_c; cd05233 246196010153 NAD(P) binding site [chemical binding]; other site 246196010154 active site 246196010155 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246196010156 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246196010157 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 246196010158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196010159 FeS/SAM binding site; other site 246196010160 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246196010161 coenzyme PQQ biosynthesis protein PqqD; Region: PQQ_PqqD; TIGR03859 246196010162 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 246196010163 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 246196010164 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 246196010165 coenzyme PQQ precursor peptide PqqA; Region: PQQ_syn_pqqA; TIGR02107 246196010166 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 246196010167 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196010168 Trp docking motif [polypeptide binding]; other site 246196010169 active site 246196010170 Actinobacterial PQQ system protein; Region: PQQ_MSMEG_3727; TIGR04339 246196010171 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 246196010172 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 246196010173 heme binding site [chemical binding]; other site 246196010174 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 246196010175 LytTr DNA-binding domain; Region: LytTR; smart00850 246196010176 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 246196010177 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 246196010178 active site 246196010179 dimer interface [polypeptide binding]; other site 246196010180 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 246196010181 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196010182 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196010183 GTP-binding protein Der; Reviewed; Region: PRK03003 246196010184 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 246196010185 G1 box; other site 246196010186 GTP/Mg2+ binding site [chemical binding]; other site 246196010187 Switch I region; other site 246196010188 G2 box; other site 246196010189 Switch II region; other site 246196010190 G3 box; other site 246196010191 G4 box; other site 246196010192 G5 box; other site 246196010193 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 246196010194 G1 box; other site 246196010195 GTP/Mg2+ binding site [chemical binding]; other site 246196010196 Switch I region; other site 246196010197 G2 box; other site 246196010198 G3 box; other site 246196010199 Switch II region; other site 246196010200 G4 box; other site 246196010201 G5 box; other site 246196010202 cytidylate kinase; Provisional; Region: cmk; PRK00023 246196010203 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 246196010204 CMP-binding site; other site 246196010205 The sites determining sugar specificity; other site 246196010206 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 246196010207 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196010208 RNA binding surface [nucleotide binding]; other site 246196010209 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 246196010210 active site 246196010211 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 246196010212 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 246196010213 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246196010214 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196010215 P-loop; other site 246196010216 Magnesium ion binding site [ion binding]; other site 246196010217 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196010218 Magnesium ion binding site [ion binding]; other site 246196010219 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 246196010220 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196010221 active site 246196010222 DNA binding site [nucleotide binding] 246196010223 Int/Topo IB signature motif; other site 246196010224 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 246196010225 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 246196010226 dimer interface [polypeptide binding]; other site 246196010227 ADP-ribose binding site [chemical binding]; other site 246196010228 active site 246196010229 nudix motif; other site 246196010230 metal binding site [ion binding]; metal-binding site 246196010231 CTP synthetase; Validated; Region: pyrG; PRK05380 246196010232 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 246196010233 Catalytic site [active] 246196010234 active site 246196010235 UTP binding site [chemical binding]; other site 246196010236 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 246196010237 active site 246196010238 putative oxyanion hole; other site 246196010239 catalytic triad [active] 246196010240 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 246196010241 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 246196010242 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 246196010243 DNA repair protein RecN; Region: recN; TIGR00634 246196010244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196010245 Walker A/P-loop; other site 246196010246 ATP binding site [chemical binding]; other site 246196010247 Q-loop/lid; other site 246196010248 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 246196010249 ABC transporter signature motif; other site 246196010250 Walker B; other site 246196010251 D-loop; other site 246196010252 H-loop/switch region; other site 246196010253 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 246196010254 ATP-NAD kinase; Region: NAD_kinase; pfam01513 246196010255 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 246196010256 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196010257 RNA binding surface [nucleotide binding]; other site 246196010258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196010259 S-adenosylmethionine binding site [chemical binding]; other site 246196010260 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 246196010261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196010262 active site 246196010263 motif I; other site 246196010264 motif II; other site 246196010265 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 246196010266 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 246196010267 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 246196010268 active site 246196010269 HIGH motif; other site 246196010270 dimer interface [polypeptide binding]; other site 246196010271 KMSKS motif; other site 246196010272 S4 RNA-binding domain; Region: S4; smart00363 246196010273 RNA binding surface [nucleotide binding]; other site 246196010274 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 246196010275 active site 246196010276 DNA binding site [nucleotide binding] 246196010277 Homeodomain-like domain; Region: HTH_23; cl17451 246196010278 Clp protease ATP binding subunit; Region: clpC; CHL00095 246196010279 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 246196010280 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196010281 Walker A/P-loop; other site 246196010282 ATP binding site [chemical binding]; other site 246196010283 Q-loop/lid; other site 246196010284 ABC transporter signature motif; other site 246196010285 Walker B; other site 246196010286 D-loop; other site 246196010287 H-loop/switch region; other site 246196010288 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246196010289 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196010290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010292 Uncharacterized conserved protein [Function unknown]; Region: COG2835 246196010293 acyl-CoA synthetase; Validated; Region: PRK07868 246196010294 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 246196010295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196010296 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196010297 active site 246196010298 CoA binding site [chemical binding]; other site 246196010299 AMP binding site [chemical binding]; other site 246196010300 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246196010301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196010302 Q-loop/lid; other site 246196010303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196010304 ABC transporter signature motif; other site 246196010305 Walker B; other site 246196010306 D-loop; other site 246196010307 ABC transporter; Region: ABC_tran_2; pfam12848 246196010308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196010309 argininosuccinate lyase; Provisional; Region: PRK00855 246196010310 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 246196010311 active sites [active] 246196010312 tetramer interface [polypeptide binding]; other site 246196010313 argininosuccinate synthase; Provisional; Region: PRK13820 246196010314 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 246196010315 ANP binding site [chemical binding]; other site 246196010316 Substrate Binding Site II [chemical binding]; other site 246196010317 Substrate Binding Site I [chemical binding]; other site 246196010318 arginine repressor; Provisional; Region: PRK03341 246196010319 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 246196010320 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 246196010321 ornithine carbamoyltransferase; Provisional; Region: PRK00779 246196010322 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 246196010323 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 246196010324 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 246196010325 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196010326 inhibitor-cofactor binding pocket; inhibition site 246196010327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196010328 catalytic residue [active] 246196010329 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 246196010330 feedback inhibition sensing region; other site 246196010331 homohexameric interface [polypeptide binding]; other site 246196010332 nucleotide binding site [chemical binding]; other site 246196010333 N-acetyl-L-glutamate binding site [chemical binding]; other site 246196010334 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 246196010335 heterotetramer interface [polypeptide binding]; other site 246196010336 active site pocket [active] 246196010337 cleavage site 246196010338 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 246196010339 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246196010340 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 246196010341 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 246196010342 putative tRNA-binding site [nucleotide binding]; other site 246196010343 B3/4 domain; Region: B3_4; pfam03483 246196010344 tRNA synthetase B5 domain; Region: B5; pfam03484 246196010345 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 246196010346 dimer interface [polypeptide binding]; other site 246196010347 motif 1; other site 246196010348 motif 3; other site 246196010349 motif 2; other site 246196010350 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 246196010351 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 246196010352 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 246196010353 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 246196010354 dimer interface [polypeptide binding]; other site 246196010355 motif 1; other site 246196010356 active site 246196010357 motif 2; other site 246196010358 motif 3; other site 246196010359 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 246196010360 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196010361 cyclase homology domain; Region: CHD; cd07302 246196010362 nucleotidyl binding site; other site 246196010363 metal binding site [ion binding]; metal-binding site 246196010364 dimer interface [polypeptide binding]; other site 246196010365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 246196010366 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196010367 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196010368 active site 246196010369 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246196010370 homotrimer interaction site [polypeptide binding]; other site 246196010371 putative active site [active] 246196010372 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196010373 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196010374 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196010375 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 246196010376 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196010377 substrate binding site [chemical binding]; other site 246196010378 ATP binding site [chemical binding]; other site 246196010379 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 246196010380 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 246196010381 dimer interface [polypeptide binding]; other site 246196010382 active site 246196010383 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196010384 substrate binding site [chemical binding]; other site 246196010385 catalytic residue [active] 246196010386 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 246196010387 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196010388 active site 246196010389 putative substrate binding pocket [chemical binding]; other site 246196010390 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196010391 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 246196010392 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 246196010393 active site 246196010394 intersubunit interface [polypeptide binding]; other site 246196010395 catalytic residue [active] 246196010396 fructuronate transporter; Provisional; Region: PRK10034; cl15264 246196010397 GntP family permease; Region: GntP_permease; pfam02447 246196010398 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 246196010399 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 246196010400 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246196010401 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 246196010402 23S rRNA binding site [nucleotide binding]; other site 246196010403 L21 binding site [polypeptide binding]; other site 246196010404 L13 binding site [polypeptide binding]; other site 246196010405 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 246196010406 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 246196010407 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 246196010408 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 246196010409 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 246196010410 CrcB-like protein; Region: CRCB; cl09114 246196010411 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 246196010412 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 246196010413 dimer interface [polypeptide binding]; other site 246196010414 putative anticodon binding site; other site 246196010415 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246196010416 motif 1; other site 246196010417 dimer interface [polypeptide binding]; other site 246196010418 active site 246196010419 motif 2; other site 246196010420 motif 3; other site 246196010421 Putative esterase; Region: Esterase; pfam00756 246196010422 CHAT domain; Region: CHAT; cl17868 246196010423 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 246196010424 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 246196010425 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 246196010426 short chain dehydrogenase; Validated; Region: PRK08264 246196010427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010428 NAD(P) binding site [chemical binding]; other site 246196010429 active site 246196010430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010432 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196010433 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 246196010434 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246196010435 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246196010436 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 246196010437 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 246196010438 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010439 Ligand Binding Site [chemical binding]; other site 246196010440 acyl-CoA thioesterase II; Region: tesB; TIGR00189 246196010441 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196010442 active site 246196010443 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196010444 catalytic triad [active] 246196010445 dimer interface [polypeptide binding]; other site 246196010446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196010448 excinuclease ABC subunit B; Provisional; Region: PRK05298 246196010449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196010450 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196010451 nucleotide binding region [chemical binding]; other site 246196010452 ATP-binding site [chemical binding]; other site 246196010453 Ultra-violet resistance protein B; Region: UvrB; pfam12344 246196010454 UvrB/uvrC motif; Region: UVR; pfam02151 246196010455 Protein of unknown function (DUF402); Region: DUF402; cl00979 246196010456 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 246196010457 Glutaminase; Region: Glutaminase; cl00907 246196010458 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196010459 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196010460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196010461 DNA-binding site [nucleotide binding]; DNA binding site 246196010462 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196010463 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196010464 classical (c) SDRs; Region: SDR_c; cd05233 246196010465 NAD(P) binding site [chemical binding]; other site 246196010466 active site 246196010467 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 246196010468 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 246196010469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010470 NAD(P) binding site [chemical binding]; other site 246196010471 active site 246196010472 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196010473 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196010474 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196010475 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196010476 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196010477 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196010478 substrate binding pocket [chemical binding]; other site 246196010479 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196010480 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196010481 classical (c) SDRs; Region: SDR_c; cd05233 246196010482 NAD(P) binding site [chemical binding]; other site 246196010483 active site 246196010484 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196010485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196010486 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 246196010487 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 246196010488 CoA-binding site [chemical binding]; other site 246196010489 ATP-binding [chemical binding]; other site 246196010490 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 246196010491 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 246196010492 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 246196010493 RNA binding site [nucleotide binding]; other site 246196010494 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 246196010495 RNA binding site [nucleotide binding]; other site 246196010496 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246196010497 RNA binding site [nucleotide binding]; other site 246196010498 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 246196010499 RNA binding site [nucleotide binding]; other site 246196010500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010502 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 246196010503 Protease prsW family; Region: PrsW-protease; pfam13367 246196010504 Uncharacterized conserved protein [Function unknown]; Region: COG2966 246196010505 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 246196010506 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 246196010507 DNA polymerase I; Provisional; Region: PRK05755 246196010508 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 246196010509 active site 246196010510 metal binding site 1 [ion binding]; metal-binding site 246196010511 putative 5' ssDNA interaction site; other site 246196010512 metal binding site 3; metal-binding site 246196010513 metal binding site 2 [ion binding]; metal-binding site 246196010514 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 246196010515 putative DNA binding site [nucleotide binding]; other site 246196010516 putative metal binding site [ion binding]; other site 246196010517 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 246196010518 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 246196010519 active site 246196010520 DNA binding site [nucleotide binding] 246196010521 catalytic site [active] 246196010522 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 246196010523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196010524 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 246196010525 putative dimerization interface [polypeptide binding]; other site 246196010526 hypothetical protein; Provisional; Region: PRK07538 246196010527 hypothetical protein; Provisional; Region: PRK07236 246196010528 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196010529 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 246196010530 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196010531 lipid-transfer protein; Provisional; Region: PRK06059 246196010532 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196010533 active site 246196010534 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 246196010535 Phosphotransferase enzyme family; Region: APH; pfam01636 246196010536 Ecdysteroid kinase; Region: EcKinase; cl17738 246196010537 tyramine oxidase; Provisional; Region: tynA; PRK11504 246196010538 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 246196010539 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 246196010540 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 246196010541 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 246196010542 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196010543 substrate binding pocket [chemical binding]; other site 246196010544 catalytic triad [active] 246196010545 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 246196010546 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196010547 active site 246196010548 dimer interface [polypeptide binding]; other site 246196010549 non-prolyl cis peptide bond; other site 246196010550 insertion regions; other site 246196010551 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196010552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196010553 substrate binding pocket [chemical binding]; other site 246196010554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 246196010555 membrane-bound complex binding site; other site 246196010556 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196010557 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196010558 Walker A/P-loop; other site 246196010559 ATP binding site [chemical binding]; other site 246196010560 Q-loop/lid; other site 246196010561 ABC transporter signature motif; other site 246196010562 Walker B; other site 246196010563 D-loop; other site 246196010564 H-loop/switch region; other site 246196010565 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196010566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196010567 dimer interface [polypeptide binding]; other site 246196010568 conserved gate region; other site 246196010569 putative PBP binding loops; other site 246196010570 ABC-ATPase subunit interface; other site 246196010571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196010572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196010573 DNA binding site [nucleotide binding] 246196010574 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246196010575 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 246196010576 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 246196010577 Ligand binding site; other site 246196010578 Putative Catalytic site; other site 246196010579 DXD motif; other site 246196010580 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 246196010581 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 246196010582 putative active site [active] 246196010583 catalytic triad [active] 246196010584 putative dimer interface [polypeptide binding]; other site 246196010585 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196010586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196010587 active site 246196010588 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 246196010589 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 246196010590 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 246196010591 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 246196010592 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 246196010593 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246196010594 Protein of unknown function DUF58; Region: DUF58; pfam01882 246196010595 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196010596 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 246196010597 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 246196010598 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 246196010599 active site 246196010600 iron coordination sites [ion binding]; other site 246196010601 substrate binding pocket [chemical binding]; other site 246196010602 precorrin-3B synthase; Region: CobG; TIGR02435 246196010603 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196010604 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196010605 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 246196010606 Precorrin-8X methylmutase; Region: CbiC; pfam02570 246196010607 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 246196010608 active site 246196010609 SAM binding site [chemical binding]; other site 246196010610 homodimer interface [polypeptide binding]; other site 246196010611 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 246196010612 active site 246196010613 SAM binding site [chemical binding]; other site 246196010614 homodimer interface [polypeptide binding]; other site 246196010615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010617 Phosphotransferase enzyme family; Region: APH; pfam01636 246196010618 Ecdysteroid kinase; Region: EcKinase; cl17738 246196010619 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 246196010620 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 246196010621 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 246196010622 active site 246196010623 SAM binding site [chemical binding]; other site 246196010624 homodimer interface [polypeptide binding]; other site 246196010625 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 246196010626 active site 246196010627 putative homodimer interface [polypeptide binding]; other site 246196010628 SAM binding site [chemical binding]; other site 246196010629 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 246196010630 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 246196010631 short chain dehydrogenase; Provisional; Region: PRK08251 246196010632 classical (c) SDRs; Region: SDR_c; cd05233 246196010633 NAD(P) binding site [chemical binding]; other site 246196010634 active site 246196010635 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196010636 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196010637 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196010638 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 246196010639 active site 246196010640 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 246196010641 dimer interface [polypeptide binding]; other site 246196010642 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196010643 metal binding site [ion binding]; metal-binding site 246196010644 5'-3' exonuclease; Region: 53EXOc; smart00475 246196010645 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 246196010646 active site 246196010647 metal binding site 1 [ion binding]; metal-binding site 246196010648 putative 5' ssDNA interaction site; other site 246196010649 metal binding site 3; metal-binding site 246196010650 metal binding site 2 [ion binding]; metal-binding site 246196010651 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 246196010652 putative DNA binding site [nucleotide binding]; other site 246196010653 putative metal binding site [ion binding]; other site 246196010654 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 246196010655 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246196010656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196010657 ATP binding site [chemical binding]; other site 246196010658 putative Mg++ binding site [ion binding]; other site 246196010659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196010660 nucleotide binding region [chemical binding]; other site 246196010661 ATP-binding site [chemical binding]; other site 246196010662 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 246196010663 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 246196010664 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 246196010665 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 246196010666 Predicted transcriptional regulator [Transcription]; Region: COG2378 246196010667 WYL domain; Region: WYL; pfam13280 246196010668 Predicted transcriptional regulator [Transcription]; Region: COG2378 246196010669 WYL domain; Region: WYL; pfam13280 246196010670 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 246196010671 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196010672 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 246196010673 Protease prsW family; Region: PrsW-protease; pfam13367 246196010674 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 246196010675 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 246196010676 active site 246196010677 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 246196010678 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 246196010679 active site 246196010680 Pup-like protein; Region: Pup; pfam05639 246196010681 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 246196010682 ectoine hydroxylase; Region: ectoine_ThpD; TIGR02408 246196010683 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 246196010684 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 246196010685 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196010686 inhibitor-cofactor binding pocket; inhibition site 246196010687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196010688 catalytic residue [active] 246196010689 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246196010690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196010691 Coenzyme A binding pocket [chemical binding]; other site 246196010692 proteasome ATPase; Region: pup_AAA; TIGR03689 246196010693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196010694 Walker A motif; other site 246196010695 ATP binding site [chemical binding]; other site 246196010696 Walker B motif; other site 246196010697 arginine finger; other site 246196010698 Ras GTPase Activating Domain; Region: RasGAP; cl02569 246196010699 Protein of unknown function (DUF503); Region: DUF503; pfam04456 246196010700 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 246196010701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196010702 S-adenosylmethionine binding site [chemical binding]; other site 246196010703 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 246196010704 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196010705 DinB superfamily; Region: DinB_2; pfam12867 246196010706 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196010707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196010708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010709 NAD(P) binding site [chemical binding]; other site 246196010710 active site 246196010711 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196010712 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196010713 short chain dehydrogenase; Provisional; Region: PRK06180 246196010714 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196010715 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 246196010716 NAD binding site [chemical binding]; other site 246196010717 substrate binding site [chemical binding]; other site 246196010718 catalytic Zn binding site [ion binding]; other site 246196010719 structural Zn binding site [ion binding]; other site 246196010720 Protein of unknown function (DUF664); Region: DUF664; pfam04978 246196010721 DinB superfamily; Region: DinB_2; pfam12867 246196010722 Condensation domain; Region: Condensation; pfam00668 246196010723 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196010724 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 246196010725 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 246196010726 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196010727 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 246196010728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196010729 motif II; other site 246196010730 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 246196010731 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 246196010732 nickel binding site [ion binding]; other site 246196010733 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 246196010734 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 246196010735 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 246196010736 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 246196010737 FAD binding pocket [chemical binding]; other site 246196010738 FAD binding motif [chemical binding]; other site 246196010739 phosphate binding motif [ion binding]; other site 246196010740 beta-alpha-beta structure motif; other site 246196010741 NAD binding pocket [chemical binding]; other site 246196010742 Iron coordination center [ion binding]; other site 246196010743 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 246196010744 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246196010745 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246196010746 putative dimer interface [polypeptide binding]; other site 246196010747 phosphoenolpyruvate synthase; Validated; Region: PRK06464 246196010748 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 246196010749 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 246196010750 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246196010751 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196010752 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196010753 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 246196010754 30S subunit binding site; other site 246196010755 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010756 Ligand Binding Site [chemical binding]; other site 246196010757 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010758 Ligand Binding Site [chemical binding]; other site 246196010759 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010760 Ligand Binding Site [chemical binding]; other site 246196010761 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010762 Ligand Binding Site [chemical binding]; other site 246196010763 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010764 Ligand Binding Site [chemical binding]; other site 246196010765 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196010766 GAF domain; Region: GAF; pfam01590 246196010767 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196010768 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246196010769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196010770 Histidine kinase; Region: HisKA_3; pfam07730 246196010771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196010772 ATP binding site [chemical binding]; other site 246196010773 Mg2+ binding site [ion binding]; other site 246196010774 G-X-G motif; other site 246196010775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 246196010776 Predicted kinase [General function prediction only]; Region: COG0645 246196010777 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196010778 dimer interface [polypeptide binding]; other site 246196010779 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196010780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196010781 active site 246196010782 phosphorylation site [posttranslational modification] 246196010783 intermolecular recognition site; other site 246196010784 dimerization interface [polypeptide binding]; other site 246196010785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196010786 DNA binding residues [nucleotide binding] 246196010787 dimerization interface [polypeptide binding]; other site 246196010788 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010789 Ligand Binding Site [chemical binding]; other site 246196010790 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010791 Ligand Binding Site [chemical binding]; other site 246196010792 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196010793 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196010794 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246196010795 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 246196010796 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 246196010797 putative substrate binding site [chemical binding]; other site 246196010798 putative ATP binding site [chemical binding]; other site 246196010799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010800 Ligand Binding Site [chemical binding]; other site 246196010801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010802 Ligand Binding Site [chemical binding]; other site 246196010803 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196010804 dimer interface [polypeptide binding]; other site 246196010805 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196010806 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246196010807 active site 246196010808 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246196010809 active site 246196010810 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 246196010811 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 246196010812 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 246196010813 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 246196010814 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196010815 dimer interface [polypeptide binding]; other site 246196010816 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196010817 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196010818 active site 246196010819 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 246196010820 dimer interface [polypeptide binding]; other site 246196010821 ligand binding site [chemical binding]; other site 246196010822 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196010823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196010824 DNA-binding site [nucleotide binding]; DNA binding site 246196010825 FCD domain; Region: FCD; pfam07729 246196010826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010830 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 246196010831 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 246196010832 putative active site [active] 246196010833 putative substrate binding site [chemical binding]; other site 246196010834 putative FMN binding site [chemical binding]; other site 246196010835 putative catalytic residues [active] 246196010836 pyruvate dehydrogenase; Provisional; Region: PRK09124 246196010837 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246196010838 PYR/PP interface [polypeptide binding]; other site 246196010839 dimer interface [polypeptide binding]; other site 246196010840 tetramer interface [polypeptide binding]; other site 246196010841 TPP binding site [chemical binding]; other site 246196010842 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196010843 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 246196010844 TPP-binding site [chemical binding]; other site 246196010845 Predicted transcriptional regulator [Transcription]; Region: COG2378 246196010846 HTH domain; Region: HTH_11; pfam08279 246196010847 WYL domain; Region: WYL; pfam13280 246196010848 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196010849 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196010850 Amidase; Region: Amidase; pfam01425 246196010851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196010852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196010853 LysR substrate binding domain; Region: LysR_substrate; pfam03466 246196010854 dimerization interface [polypeptide binding]; other site 246196010855 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 246196010856 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 246196010857 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 246196010858 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 246196010859 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196010860 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196010861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010862 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 246196010863 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196010864 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 246196010865 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196010866 potential frameshift: common BLAST hit: gi|386355104|ref|YP_006053350.1| alpha/beta hydrolase fold protein 246196010867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196010868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196010869 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196010870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196010871 DNA-binding site [nucleotide binding]; DNA binding site 246196010872 FCD domain; Region: FCD; pfam07729 246196010873 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196010874 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196010875 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196010876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196010877 active site 246196010878 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196010879 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196010880 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196010881 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196010882 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196010883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010884 putative substrate translocation pore; other site 246196010885 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 246196010886 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196010887 acyl-activating enzyme (AAE) consensus motif; other site 246196010888 AMP binding site [chemical binding]; other site 246196010889 active site 246196010890 CoA binding site [chemical binding]; other site 246196010891 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 246196010892 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196010893 AsnC family; Region: AsnC_trans_reg; pfam01037 246196010894 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196010895 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 246196010896 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 246196010897 metal binding site [ion binding]; metal-binding site 246196010898 dimer interface [polypeptide binding]; other site 246196010899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010900 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196010901 putative substrate translocation pore; other site 246196010902 Putative cyclase; Region: Cyclase; pfam04199 246196010903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010904 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196010905 putative substrate translocation pore; other site 246196010906 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196010907 short chain dehydrogenase; Provisional; Region: PRK06125 246196010908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010909 NAD(P) binding site [chemical binding]; other site 246196010910 active site 246196010911 allantoate amidohydrolase; Reviewed; Region: PRK09290 246196010912 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 246196010913 active site 246196010914 metal binding site [ion binding]; metal-binding site 246196010915 dimer interface [polypeptide binding]; other site 246196010916 phenylhydantoinase; Validated; Region: PRK08323 246196010917 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 246196010918 tetramer interface [polypeptide binding]; other site 246196010919 active site 246196010920 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196010921 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 246196010922 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196010923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196010924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196010925 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 246196010926 ligand binding site [chemical binding]; other site 246196010927 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196010928 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196010929 Walker A/P-loop; other site 246196010930 ATP binding site [chemical binding]; other site 246196010931 Q-loop/lid; other site 246196010932 ABC transporter signature motif; other site 246196010933 Walker B; other site 246196010934 D-loop; other site 246196010935 H-loop/switch region; other site 246196010936 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196010937 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196010938 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196010939 TM-ABC transporter signature motif; other site 246196010940 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 246196010941 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196010942 putative NAD(P) binding site [chemical binding]; other site 246196010943 catalytic Zn binding site [ion binding]; other site 246196010944 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 246196010945 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196010946 classical (c) SDRs; Region: SDR_c; cd05233 246196010947 NAD(P) binding site [chemical binding]; other site 246196010948 active site 246196010949 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196010950 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196010951 oxidoreductase; Region: PLN02485 246196010952 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196010953 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196010954 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196010955 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196010956 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196010957 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196010958 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196010959 active site 246196010960 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 246196010961 phenylhydantoinase; Validated; Region: PRK08323 246196010962 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 246196010963 tetramer interface [polypeptide binding]; other site 246196010964 active site 246196010965 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196010966 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 246196010967 allantoate amidohydrolase; Reviewed; Region: PRK09290 246196010968 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 246196010969 active site 246196010970 metal binding site [ion binding]; metal-binding site 246196010971 dimer interface [polypeptide binding]; other site 246196010972 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196010973 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246196010974 active site 246196010975 NTP binding site [chemical binding]; other site 246196010976 metal binding triad [ion binding]; metal-binding site 246196010977 antibiotic binding site [chemical binding]; other site 246196010978 AMP-binding domain protein; Validated; Region: PRK08315 246196010979 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196010980 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 246196010981 acyl-activating enzyme (AAE) consensus motif; other site 246196010982 putative AMP binding site [chemical binding]; other site 246196010983 putative active site [active] 246196010984 putative CoA binding site [chemical binding]; other site 246196010985 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196010986 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196010987 substrate binding site [chemical binding]; other site 246196010988 oxyanion hole (OAH) forming residues; other site 246196010989 trimer interface [polypeptide binding]; other site 246196010990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010992 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 246196010993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196010994 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246196010995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196010998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196010999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196011000 dimerization interface [polypeptide binding]; other site 246196011001 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196011002 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 246196011003 putative NAD(P) binding site [chemical binding]; other site 246196011004 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196011005 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196011006 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196011007 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196011008 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196011009 putative NAD(P) binding site [chemical binding]; other site 246196011010 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 246196011011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011012 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196011013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011014 NAD(P) binding site [chemical binding]; other site 246196011015 active site 246196011016 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 246196011017 active site 246196011018 oxalacetate binding site [chemical binding]; other site 246196011019 citrylCoA binding site [chemical binding]; other site 246196011020 coenzyme A binding site [chemical binding]; other site 246196011021 catalytic triad [active] 246196011022 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 246196011023 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196011024 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 246196011025 acyl-activating enzyme (AAE) consensus motif; other site 246196011026 putative AMP binding site [chemical binding]; other site 246196011027 putative active site [active] 246196011028 putative CoA binding site [chemical binding]; other site 246196011029 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196011030 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196011031 Pseudomonas putida vanillin dehydrogenase-like; Region: ALDH_VaniDH_like; cd07150 246196011032 NAD(P) binding site [chemical binding]; other site 246196011033 catalytic residues [active] 246196011034 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 246196011035 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 246196011036 catalytic Zn binding site [ion binding]; other site 246196011037 NAD binding site [chemical binding]; other site 246196011038 structural Zn binding site [ion binding]; other site 246196011039 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 246196011040 putative FMN binding site [chemical binding]; other site 246196011041 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 246196011042 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 246196011043 active site 246196011044 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196011045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196011046 DNA-binding site [nucleotide binding]; DNA binding site 246196011047 FCD domain; Region: FCD; pfam07729 246196011048 active site 246196011049 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196011050 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196011051 GAF domain; Region: GAF; pfam01590 246196011052 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 246196011053 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196011054 Muconolactone delta-isomerase; Region: MIase; cl01992 246196011055 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196011056 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196011057 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 246196011058 Putative cyclase; Region: Cyclase; pfam04199 246196011059 benzoate transport; Region: 2A0115; TIGR00895 246196011060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011061 putative substrate translocation pore; other site 246196011062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011063 AAA ATPase domain; Region: AAA_16; pfam13191 246196011064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196011065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196011066 DNA binding residues [nucleotide binding] 246196011067 dimerization interface [polypeptide binding]; other site 246196011068 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196011069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011070 NAD(P) binding site [chemical binding]; other site 246196011071 active site 246196011072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011073 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196011074 NAD(P) binding site [chemical binding]; other site 246196011075 active site 246196011076 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196011077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196011078 DNA-binding site [nucleotide binding]; DNA binding site 246196011079 FCD domain; Region: FCD; pfam07729 246196011080 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196011081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011082 putative substrate translocation pore; other site 246196011083 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 246196011084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196011085 motif II; other site 246196011086 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196011087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196011088 homodimer interface [polypeptide binding]; other site 246196011089 catalytic residue [active] 246196011090 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246196011091 homotrimer interaction site [polypeptide binding]; other site 246196011092 putative active site [active] 246196011093 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196011094 Amidase; Region: Amidase; cl11426 246196011095 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 246196011096 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196011097 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196011098 putative NAD(P) binding site [chemical binding]; other site 246196011099 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196011100 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196011101 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196011102 acyl-activating enzyme (AAE) consensus motif; other site 246196011103 acyl-activating enzyme (AAE) consensus motif; other site 246196011104 putative AMP binding site [chemical binding]; other site 246196011105 putative active site [active] 246196011106 putative CoA binding site [chemical binding]; other site 246196011107 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 246196011108 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 246196011109 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196011110 putative NAD(P) binding site [chemical binding]; other site 246196011111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196011112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011113 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196011114 Winged helix-turn helix; Region: HTH_29; pfam13551 246196011115 Homeodomain-like domain; Region: HTH_32; pfam13565 246196011116 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196011117 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 246196011118 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246196011119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011120 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196011121 NAD(P) binding site [chemical binding]; other site 246196011122 active site 246196011123 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 246196011124 CoA binding domain; Region: CoA_binding_2; pfam13380 246196011125 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 246196011126 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 246196011127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196011128 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196011129 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196011130 active site 246196011131 enoyl-CoA hydratase; Provisional; Region: PRK08138 246196011132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011133 substrate binding site [chemical binding]; other site 246196011134 oxyanion hole (OAH) forming residues; other site 246196011135 trimer interface [polypeptide binding]; other site 246196011136 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 246196011137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011138 putative substrate translocation pore; other site 246196011139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011140 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196011141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196011142 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196011143 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196011144 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196011145 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196011146 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196011147 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196011148 active site 246196011149 non-prolyl cis peptide bond; other site 246196011150 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196011151 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196011152 active site 246196011153 non-prolyl cis peptide bond; other site 246196011154 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011155 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196011156 active site 246196011157 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196011158 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196011159 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196011160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011161 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196011162 putative substrate translocation pore; other site 246196011163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196011164 Transposase; Region: HTH_Tnp_1; cl17663 246196011165 putative transposase OrfB; Reviewed; Region: PHA02517 246196011166 Integrase core domain; Region: rve; pfam00665 246196011167 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196011168 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196011169 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196011170 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196011171 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196011172 active site 246196011173 non-prolyl cis peptide bond; other site 246196011174 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 246196011175 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246196011176 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196011177 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196011178 active site 246196011179 catalytic tetrad [active] 246196011180 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196011181 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011182 active site 246196011183 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196011184 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196011185 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196011186 active site 246196011187 non-prolyl cis peptide bond; other site 246196011188 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196011189 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011190 active site 246196011191 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196011192 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011193 Walker A/P-loop; other site 246196011194 ATP binding site [chemical binding]; other site 246196011195 Q-loop/lid; other site 246196011196 ABC transporter signature motif; other site 246196011197 Walker B; other site 246196011198 D-loop; other site 246196011199 H-loop/switch region; other site 246196011200 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 246196011201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011202 Walker A/P-loop; other site 246196011203 ATP binding site [chemical binding]; other site 246196011204 Q-loop/lid; other site 246196011205 ABC transporter signature motif; other site 246196011206 Walker B; other site 246196011207 D-loop; other site 246196011208 H-loop/switch region; other site 246196011209 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196011210 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 246196011211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011212 dimer interface [polypeptide binding]; other site 246196011213 conserved gate region; other site 246196011214 putative PBP binding loops; other site 246196011215 ABC-ATPase subunit interface; other site 246196011216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196011217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011218 dimer interface [polypeptide binding]; other site 246196011219 conserved gate region; other site 246196011220 putative PBP binding loops; other site 246196011221 ABC-ATPase subunit interface; other site 246196011222 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196011223 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 246196011224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196011225 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 246196011226 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196011227 active site 246196011228 dimer interface [polypeptide binding]; other site 246196011229 non-prolyl cis peptide bond; other site 246196011230 insertion regions; other site 246196011231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011232 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196011233 putative substrate translocation pore; other site 246196011234 putative transposase OrfB; Reviewed; Region: PHA02517 246196011235 Integrase core domain; Region: rve; pfam00665 246196011236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196011237 Transposase; Region: HTH_Tnp_1; cl17663 246196011238 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196011239 catalytic core [active] 246196011240 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 246196011241 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 246196011242 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 246196011243 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 246196011244 ligand binding site [chemical binding]; other site 246196011245 homodimer interface [polypeptide binding]; other site 246196011246 NAD(P) binding site [chemical binding]; other site 246196011247 trimer interface B [polypeptide binding]; other site 246196011248 trimer interface A [polypeptide binding]; other site 246196011249 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 246196011250 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 246196011251 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196011252 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196011253 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196011254 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196011255 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 246196011256 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 246196011257 acyl-activating enzyme (AAE) consensus motif; other site 246196011258 putative AMP binding site [chemical binding]; other site 246196011259 putative active site [active] 246196011260 putative CoA binding site [chemical binding]; other site 246196011261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011262 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196011263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011264 substrate binding site [chemical binding]; other site 246196011265 oxyanion hole (OAH) forming residues; other site 246196011266 trimer interface [polypeptide binding]; other site 246196011267 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 246196011268 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196011269 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196011270 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246196011271 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196011272 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196011273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011274 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196011275 NAD(P) binding site [chemical binding]; other site 246196011276 active site 246196011277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196011278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011279 active site 246196011280 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 246196011281 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011282 substrate binding site [chemical binding]; other site 246196011283 oxyanion hole (OAH) forming residues; other site 246196011284 trimer interface [polypeptide binding]; other site 246196011285 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196011286 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196011287 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196011288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196011289 DNA-binding site [nucleotide binding]; DNA binding site 246196011290 FCD domain; Region: FCD; pfam07729 246196011291 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196011292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011293 putative substrate translocation pore; other site 246196011294 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196011295 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196011296 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 246196011297 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196011298 classical (c) SDRs; Region: SDR_c; cd05233 246196011299 NAD(P) binding site [chemical binding]; other site 246196011300 active site 246196011301 Isochorismatase family; Region: Isochorismatase; pfam00857 246196011302 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 246196011303 catalytic triad [active] 246196011304 conserved cis-peptide bond; other site 246196011305 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196011306 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196011307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196011308 S-adenosylmethionine binding site [chemical binding]; other site 246196011309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011310 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 246196011311 putative active site [active] 246196011312 putative catalytic site [active] 246196011313 Integrase core domain; Region: rve; pfam00665 246196011314 Integrase core domain; Region: rve_3; pfam13683 246196011315 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196011316 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196011317 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 246196011318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011319 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 246196011320 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196011321 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 246196011322 putative active site [active] 246196011323 catalytic triad [active] 246196011324 putative dimer interface [polypeptide binding]; other site 246196011325 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196011326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196011327 DNA-binding site [nucleotide binding]; DNA binding site 246196011328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196011329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196011330 homodimer interface [polypeptide binding]; other site 246196011331 catalytic residue [active] 246196011332 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196011333 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 246196011334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196011335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011336 Uncharacterized conserved protein [Function unknown]; Region: COG5470 246196011337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196011338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196011339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196011340 dimerization interface [polypeptide binding]; other site 246196011341 Cupin domain; Region: Cupin_2; cl17218 246196011342 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 246196011343 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 246196011344 NADP binding site [chemical binding]; other site 246196011345 dimer interface [polypeptide binding]; other site 246196011346 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196011347 acetaldehyde dehydrogenase; Validated; Region: PRK08300 246196011348 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246196011349 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 246196011350 4-hydroxy-2-oxovalerate aldolase; Region: 4OH_2_O_val_ald; TIGR03217 246196011351 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 246196011352 active site 246196011353 catalytic residues [active] 246196011354 metal binding site [ion binding]; metal-binding site 246196011355 DmpG-like communication domain; Region: DmpG_comm; pfam07836 246196011356 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246196011357 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196011358 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196011359 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196011360 FMN-binding pocket [chemical binding]; other site 246196011361 flavin binding motif; other site 246196011362 phosphate binding motif [ion binding]; other site 246196011363 beta-alpha-beta structure motif; other site 246196011364 NAD binding pocket [chemical binding]; other site 246196011365 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196011366 catalytic loop [active] 246196011367 iron binding site [ion binding]; other site 246196011368 Cytochrome P450; Region: p450; cl12078 246196011369 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196011370 Transposase, Mutator family; Region: Transposase_mut; pfam00872 246196011371 MULE transposase domain; Region: MULE; pfam10551 246196011372 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 246196011373 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 246196011374 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196011375 active site 246196011376 DNA binding site [nucleotide binding] 246196011377 Int/Topo IB signature motif; other site 246196011378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196011379 active site 246196011380 DNA binding site [nucleotide binding] 246196011381 Int/Topo IB signature motif; other site 246196011382 Transposase, Mutator family; Region: Transposase_mut; pfam00872 246196011383 MULE transposase domain; Region: MULE; pfam10551 246196011384 Protein of unknown function (DUF993); Region: DUF993; pfam06187 246196011385 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196011386 classical (c) SDRs; Region: SDR_c; cd05233 246196011387 NAD(P) binding site [chemical binding]; other site 246196011388 active site 246196011389 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196011390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011391 substrate binding site [chemical binding]; other site 246196011392 oxyanion hole (OAH) forming residues; other site 246196011393 trimer interface [polypeptide binding]; other site 246196011394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196011395 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 246196011396 NAD(P) binding site [chemical binding]; other site 246196011397 catalytic residues [active] 246196011398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196011399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011400 active site 246196011401 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 246196011402 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196011403 NAD binding site [chemical binding]; other site 246196011404 catalytic Zn binding site [ion binding]; other site 246196011405 substrate binding site [chemical binding]; other site 246196011406 structural Zn binding site [ion binding]; other site 246196011407 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 246196011408 Coenzyme A transferase; Region: CoA_trans; smart00882 246196011409 Coenzyme A transferase; Region: CoA_trans; cl17247 246196011410 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196011411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011412 NAD(P) binding site [chemical binding]; other site 246196011413 active site 246196011414 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196011415 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196011416 Walker A/P-loop; other site 246196011417 ATP binding site [chemical binding]; other site 246196011418 Q-loop/lid; other site 246196011419 ABC transporter signature motif; other site 246196011420 Walker B; other site 246196011421 D-loop; other site 246196011422 H-loop/switch region; other site 246196011423 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196011424 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196011425 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196011426 TM-ABC transporter signature motif; other site 246196011427 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 246196011428 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 246196011429 ligand binding site [chemical binding]; other site 246196011430 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 246196011431 dimer interaction site [polypeptide binding]; other site 246196011432 substrate-binding tunnel; other site 246196011433 active site 246196011434 catalytic site [active] 246196011435 substrate binding site [chemical binding]; other site 246196011436 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196011437 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196011438 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196011439 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196011440 dimerization interface [polypeptide binding]; other site 246196011441 putative DNA binding site [nucleotide binding]; other site 246196011442 putative Zn2+ binding site [ion binding]; other site 246196011443 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 246196011444 putative hydrophobic ligand binding site [chemical binding]; other site 246196011445 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246196011446 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246196011447 mercuric reductase; Validated; Region: PRK06370 246196011448 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196011449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196011450 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246196011451 Predicted membrane protein [Function unknown]; Region: COG3918 246196011452 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 246196011453 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 246196011454 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 246196011455 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 246196011456 homodimer interface [polypeptide binding]; other site 246196011457 putative metal binding site [ion binding]; other site 246196011458 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 246196011459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011460 putative substrate translocation pore; other site 246196011461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011462 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 246196011463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196011464 motif II; other site 246196011465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011466 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 246196011467 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 246196011468 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 246196011469 substrate binding pocket [chemical binding]; other site 246196011470 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 246196011471 B12 binding site [chemical binding]; other site 246196011472 cobalt ligand [ion binding]; other site 246196011473 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 246196011474 PAC2 family; Region: PAC2; pfam09754 246196011475 Uncharacterized conserved protein [Function unknown]; Region: COG5361 246196011476 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 246196011477 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 246196011478 short chain dehydrogenase; Provisional; Region: PRK05872 246196011479 classical (c) SDRs; Region: SDR_c; cd05233 246196011480 NAD(P) binding site [chemical binding]; other site 246196011481 active site 246196011482 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246196011483 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 246196011484 active site 246196011485 HIGH motif; other site 246196011486 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246196011487 KMSKS motif; other site 246196011488 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 246196011489 putative tRNA binding surface [nucleotide binding]; other site 246196011490 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 246196011491 active site 246196011492 conserved hypothetical protein; Region: TIGR03843 246196011493 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 246196011494 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196011495 catalytic core [active] 246196011496 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 246196011497 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 246196011498 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 246196011499 quinone interaction residues [chemical binding]; other site 246196011500 active site 246196011501 catalytic residues [active] 246196011502 FMN binding site [chemical binding]; other site 246196011503 substrate binding site [chemical binding]; other site 246196011504 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 246196011505 substrate binding site [chemical binding]; other site 246196011506 hypothetical protein; Provisional; Region: PRK07906 246196011507 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 246196011508 putative metal binding site [ion binding]; other site 246196011509 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 246196011510 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 246196011511 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 246196011512 active site 246196011513 catalytic triad [active] 246196011514 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 246196011515 putative heme binding pocket [chemical binding]; other site 246196011516 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196011517 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196011518 DNA binding residues [nucleotide binding] 246196011519 dimerization interface [polypeptide binding]; other site 246196011520 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 246196011521 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 246196011522 [4Fe-4S] binding site [ion binding]; other site 246196011523 molybdopterin cofactor binding site; other site 246196011524 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 246196011525 molybdopterin cofactor binding site; other site 246196011526 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 246196011527 Flavodoxin; Region: Flavodoxin_1; pfam00258 246196011528 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 246196011529 FAD binding pocket [chemical binding]; other site 246196011530 FAD binding motif [chemical binding]; other site 246196011531 catalytic residues [active] 246196011532 NAD binding pocket [chemical binding]; other site 246196011533 phosphate binding motif [ion binding]; other site 246196011534 beta-alpha-beta structure motif; other site 246196011535 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196011536 Ligand Binding Site [chemical binding]; other site 246196011537 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 246196011538 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 246196011539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 246196011540 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 246196011541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196011542 putative active site [active] 246196011543 heme pocket [chemical binding]; other site 246196011544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196011545 ATP binding site [chemical binding]; other site 246196011546 Mg2+ binding site [ion binding]; other site 246196011547 G-X-G motif; other site 246196011548 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 246196011549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196011550 active site 246196011551 phosphorylation site [posttranslational modification] 246196011552 intermolecular recognition site; other site 246196011553 dimerization interface [polypeptide binding]; other site 246196011554 Transcriptional regulator; Region: CitT; pfam12431 246196011555 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196011556 Cytochrome P450; Region: p450; cl12078 246196011557 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 246196011558 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 246196011559 catalytic triad [active] 246196011560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196011561 active site 246196011562 DivIVA domain; Region: DivI1A_domain; TIGR03544 246196011563 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 246196011564 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 246196011565 Predicted integral membrane protein [Function unknown]; Region: COG0762 246196011566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 246196011567 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 246196011568 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196011569 catalytic residue [active] 246196011570 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 246196011571 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 246196011572 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 246196011573 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 246196011574 nucleotide binding site [chemical binding]; other site 246196011575 SulA interaction site; other site 246196011576 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 246196011577 Cell division protein FtsQ; Region: FtsQ; pfam03799 246196011578 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 246196011579 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246196011580 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196011581 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196011582 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 246196011583 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 246196011584 active site 246196011585 homodimer interface [polypeptide binding]; other site 246196011586 cell division protein FtsW; Region: ftsW; TIGR02614 246196011587 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 246196011588 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196011589 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196011590 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 246196011591 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 246196011592 Mg++ binding site [ion binding]; other site 246196011593 putative catalytic motif [active] 246196011594 putative substrate binding site [chemical binding]; other site 246196011595 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 246196011596 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196011597 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196011598 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 246196011599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196011600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196011601 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 246196011602 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 246196011603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196011604 MraW methylase family; Region: Methyltransf_5; cl17771 246196011605 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 246196011606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 246196011607 MraZ protein; Region: MraZ; pfam02381 246196011608 MraZ protein; Region: MraZ; pfam02381 246196011609 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 246196011610 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246196011611 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196011612 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 246196011613 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246196011614 substrate binding pocket [chemical binding]; other site 246196011615 chain length determination region; other site 246196011616 substrate-Mg2+ binding site; other site 246196011617 catalytic residues [active] 246196011618 aspartate-rich region 1; other site 246196011619 active site lid residues [active] 246196011620 aspartate-rich region 2; other site 246196011621 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 246196011622 CpeS-like protein; Region: CpeS; pfam09367 246196011623 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196011624 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196011625 active site 246196011626 ATP binding site [chemical binding]; other site 246196011627 substrate binding site [chemical binding]; other site 246196011628 activation loop (A-loop); other site 246196011629 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 246196011630 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 246196011631 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246196011632 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196011633 putative acyl-acceptor binding pocket; other site 246196011634 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 246196011635 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246196011636 P loop; other site 246196011637 Nucleotide binding site [chemical binding]; other site 246196011638 DTAP/Switch II; other site 246196011639 Switch I; other site 246196011640 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 246196011641 putative hydrophobic ligand binding site [chemical binding]; other site 246196011642 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246196011643 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 246196011644 acyl-activating enzyme (AAE) consensus motif; other site 246196011645 putative AMP binding site [chemical binding]; other site 246196011646 putative active site [active] 246196011647 putative CoA binding site [chemical binding]; other site 246196011648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196011649 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196011650 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246196011651 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196011652 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196011653 hypothetical protein; Validated; Region: PRK07883 246196011654 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 246196011655 active site 246196011656 catalytic site [active] 246196011657 substrate binding site [chemical binding]; other site 246196011658 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 246196011659 GIY-YIG motif/motif A; other site 246196011660 active site 246196011661 catalytic site [active] 246196011662 putative DNA binding site [nucleotide binding]; other site 246196011663 metal binding site [ion binding]; metal-binding site 246196011664 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 246196011665 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 246196011666 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 246196011667 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 246196011668 Subunit I/III interface [polypeptide binding]; other site 246196011669 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 246196011670 Cytochrome c; Region: Cytochrom_C; pfam00034 246196011671 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246196011672 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 246196011673 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246196011674 iron-sulfur cluster [ion binding]; other site 246196011675 [2Fe-2S] cluster binding site [ion binding]; other site 246196011676 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 246196011677 heme bH binding site [chemical binding]; other site 246196011678 intrachain domain interface; other site 246196011679 heme bL binding site [chemical binding]; other site 246196011680 interchain domain interface [polypeptide binding]; other site 246196011681 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 246196011682 Qo binding site; other site 246196011683 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 246196011684 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196011685 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 246196011686 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 246196011687 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 246196011688 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 246196011689 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 246196011690 active site 246196011691 dimer interface [polypeptide binding]; other site 246196011692 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 246196011693 Ligand Binding Site [chemical binding]; other site 246196011694 Molecular Tunnel; other site 246196011695 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 246196011696 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196011697 substrate binding site [chemical binding]; other site 246196011698 ATP binding site [chemical binding]; other site 246196011699 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 246196011700 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 246196011701 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 246196011702 homotrimer interface [polypeptide binding]; other site 246196011703 Walker A motif; other site 246196011704 GTP binding site [chemical binding]; other site 246196011705 Walker B motif; other site 246196011706 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 246196011707 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 246196011708 putative dimer interface [polypeptide binding]; other site 246196011709 active site pocket [active] 246196011710 putative cataytic base [active] 246196011711 cobalamin synthase; Reviewed; Region: cobS; PRK00235 246196011712 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 246196011713 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 246196011714 homodimer interface [polypeptide binding]; other site 246196011715 substrate-cofactor binding pocket; other site 246196011716 catalytic residue [active] 246196011717 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 246196011718 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 246196011719 cyclase homology domain; Region: CHD; cd07302 246196011720 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196011721 nucleotidyl binding site; other site 246196011722 metal binding site [ion binding]; metal-binding site 246196011723 dimer interface [polypeptide binding]; other site 246196011724 multifunctional aminopeptidase A; Provisional; Region: PRK00913 246196011725 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 246196011726 interface (dimer of trimers) [polypeptide binding]; other site 246196011727 Substrate-binding/catalytic site; other site 246196011728 Zn-binding sites [ion binding]; other site 246196011729 short chain dehydrogenase; Validated; Region: PRK05855 246196011730 classical (c) SDRs; Region: SDR_c; cd05233 246196011731 NAD(P) binding site [chemical binding]; other site 246196011732 active site 246196011733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246196011734 E3 interaction surface; other site 246196011735 lipoyl attachment site [posttranslational modification]; other site 246196011736 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 246196011737 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246196011738 E3 interaction surface; other site 246196011739 lipoyl attachment site [posttranslational modification]; other site 246196011740 e3 binding domain; Region: E3_binding; pfam02817 246196011741 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246196011742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011743 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 246196011744 NAD(P) binding site [chemical binding]; other site 246196011745 active site 246196011746 lipoate-protein ligase B; Provisional; Region: PRK14345 246196011747 lipoyl synthase; Provisional; Region: PRK05481 246196011748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196011749 FeS/SAM binding site; other site 246196011750 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 246196011751 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196011752 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 246196011753 active site 246196011754 RDD family; Region: RDD; pfam06271 246196011755 glutamine synthetase, type I; Region: GlnA; TIGR00653 246196011756 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246196011757 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196011758 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 246196011759 putative active site [active] 246196011760 dimerization interface [polypeptide binding]; other site 246196011761 putative tRNAtyr binding site [nucleotide binding]; other site 246196011762 Predicted membrane protein [Function unknown]; Region: COG2259 246196011763 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 246196011764 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246196011765 metal binding triad; other site 246196011766 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 246196011767 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246196011768 metal binding triad; other site 246196011769 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 246196011770 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196011771 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246196011772 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196011773 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246196011774 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196011775 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196011776 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246196011777 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196011778 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196011779 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196011780 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246196011781 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 246196011782 oligomerization interface [polypeptide binding]; other site 246196011783 active site 246196011784 metal binding site [ion binding]; metal-binding site 246196011785 enoyl-CoA hydratase; Provisional; Region: PRK08140 246196011786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011787 substrate binding site [chemical binding]; other site 246196011788 oxyanion hole (OAH) forming residues; other site 246196011789 trimer interface [polypeptide binding]; other site 246196011790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196011791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011792 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 246196011793 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196011794 acyl-activating enzyme (AAE) consensus motif; other site 246196011795 active site 246196011796 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 246196011797 putative active site; other site 246196011798 putative metal binding residues [ion binding]; other site 246196011799 signature motif; other site 246196011800 putative triphosphate binding site [ion binding]; other site 246196011801 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 246196011802 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 246196011803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196011804 S-adenosylmethionine binding site [chemical binding]; other site 246196011805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196011806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196011807 sequence-specific DNA binding site [nucleotide binding]; other site 246196011808 salt bridge; other site 246196011809 Cupin domain; Region: Cupin_2; pfam07883 246196011810 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 246196011811 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 246196011812 RNA/DNA hybrid binding site [nucleotide binding]; other site 246196011813 active site 246196011814 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196011815 catalytic core [active] 246196011816 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 246196011817 Putative zinc ribbon domain; Region: DUF164; pfam02591 246196011818 Uncharacterized conserved protein [Function unknown]; Region: COG0327 246196011819 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 246196011820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 246196011821 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 246196011822 Acid Phosphatase; Region: Acid_PPase; cl17256 246196011823 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 246196011824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196011825 motif II; other site 246196011826 Low molecular weight phosphatase family; Region: LMWPc; cd00115 246196011827 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 246196011828 active site 246196011829 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 246196011830 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 246196011831 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196011832 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196011833 active site 246196011834 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246196011835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196011836 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196011837 DNA binding residues [nucleotide binding] 246196011838 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 246196011839 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 246196011840 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246196011841 DNA binding site [nucleotide binding] 246196011842 active site 246196011843 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 246196011844 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 246196011845 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246196011846 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 246196011847 dimer interface [polypeptide binding]; other site 246196011848 catalytic triad [active] 246196011849 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 246196011850 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 246196011851 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 246196011852 dimer interface [polypeptide binding]; other site 246196011853 TPP-binding site [chemical binding]; other site 246196011854 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196011855 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196011856 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246196011857 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246196011858 acyl carrier protein; Provisional; Region: acpP; PRK00982 246196011859 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 246196011860 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246196011861 dimer interface [polypeptide binding]; other site 246196011862 active site 246196011863 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 246196011864 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246196011865 dimer interface [polypeptide binding]; other site 246196011866 active site 246196011867 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196011868 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196011869 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196011870 short chain dehydrogenase; Provisional; Region: PRK12744 246196011871 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 246196011872 NADP binding site [chemical binding]; other site 246196011873 homodimer interface [polypeptide binding]; other site 246196011874 active site 246196011875 substrate binding site [chemical binding]; other site 246196011876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196011877 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196011878 dimerization interface [polypeptide binding]; other site 246196011879 substrate binding pocket [chemical binding]; other site 246196011880 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 246196011881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196011882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011883 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196011884 FAD binding domain; Region: FAD_binding_4; pfam01565 246196011885 diacylglycerol kinase; Reviewed; Region: PRK11914 246196011886 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246196011887 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 246196011888 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196011889 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196011890 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196011891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196011892 S-adenosylmethionine binding site [chemical binding]; other site 246196011893 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196011894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196011895 DNA binding residues [nucleotide binding] 246196011896 dimerization interface [polypeptide binding]; other site 246196011897 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 246196011898 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196011899 NAD binding site [chemical binding]; other site 246196011900 catalytic Zn binding site [ion binding]; other site 246196011901 substrate binding site [chemical binding]; other site 246196011902 structural Zn binding site [ion binding]; other site 246196011903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196011904 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196011905 Short C-terminal domain; Region: SHOCT; pfam09851 246196011906 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 246196011907 hypothetical protein; Validated; Region: PRK07586 246196011908 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196011909 PYR/PP interface [polypeptide binding]; other site 246196011910 dimer interface [polypeptide binding]; other site 246196011911 TPP binding site [chemical binding]; other site 246196011912 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 246196011913 TPP-binding site [chemical binding]; other site 246196011914 dimer interface [polypeptide binding]; other site 246196011915 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 246196011916 nucleotide binding site [chemical binding]; other site 246196011917 SBD interface [polypeptide binding]; other site 246196011918 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196011919 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196011920 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196011921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011922 NAD(P) binding site [chemical binding]; other site 246196011923 active site 246196011924 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196011925 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196011926 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 246196011927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196011928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011929 dimer interface [polypeptide binding]; other site 246196011930 conserved gate region; other site 246196011931 putative PBP binding loops; other site 246196011932 ABC-ATPase subunit interface; other site 246196011933 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 246196011934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011935 putative PBP binding loops; other site 246196011936 dimer interface [polypeptide binding]; other site 246196011937 ABC-ATPase subunit interface; other site 246196011938 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196011939 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011940 Walker A/P-loop; other site 246196011941 ATP binding site [chemical binding]; other site 246196011942 Q-loop/lid; other site 246196011943 ABC transporter signature motif; other site 246196011944 Walker B; other site 246196011945 D-loop; other site 246196011946 H-loop/switch region; other site 246196011947 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196011948 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011949 Walker A/P-loop; other site 246196011950 ATP binding site [chemical binding]; other site 246196011951 Q-loop/lid; other site 246196011952 ABC transporter signature motif; other site 246196011953 Walker B; other site 246196011954 D-loop; other site 246196011955 H-loop/switch region; other site 246196011956 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196011957 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196011958 classical (c) SDRs; Region: SDR_c; cd05233 246196011959 NAD(P) binding site [chemical binding]; other site 246196011960 active site 246196011961 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 246196011962 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196011963 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196011964 Ligand Binding Site [chemical binding]; other site 246196011965 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196011966 Ligand Binding Site [chemical binding]; other site 246196011967 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196011968 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196011969 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196011970 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196011971 active site 246196011972 ATP binding site [chemical binding]; other site 246196011973 substrate binding site [chemical binding]; other site 246196011974 activation loop (A-loop); other site 246196011975 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 246196011976 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196011977 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196011978 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196011979 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196011980 FMN-binding pocket [chemical binding]; other site 246196011981 flavin binding motif; other site 246196011982 phosphate binding motif [ion binding]; other site 246196011983 beta-alpha-beta structure motif; other site 246196011984 NAD binding pocket [chemical binding]; other site 246196011985 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196011986 catalytic loop [active] 246196011987 iron binding site [ion binding]; other site 246196011988 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196011989 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196011990 iron-sulfur cluster [ion binding]; other site 246196011991 [2Fe-2S] cluster binding site [ion binding]; other site 246196011992 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246196011993 hydrophobic ligand binding site; other site 246196011994 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 246196011995 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 246196011996 active site 246196011997 catalytic site [active] 246196011998 Zn binding site [ion binding]; other site 246196011999 tetramer interface [polypeptide binding]; other site 246196012000 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 246196012001 agmatinase; Region: agmatinase; TIGR01230 246196012002 oligomer interface [polypeptide binding]; other site 246196012003 putative active site [active] 246196012004 Mn binding site [ion binding]; other site 246196012005 short chain dehydrogenase; Provisional; Region: PRK07577 246196012006 classical (c) SDRs; Region: SDR_c; cd05233 246196012007 NAD(P) binding site [chemical binding]; other site 246196012008 active site 246196012009 short chain dehydrogenase; Provisional; Region: PRK07326 246196012010 classical (c) SDRs; Region: SDR_c; cd05233 246196012011 NAD(P) binding site [chemical binding]; other site 246196012012 active site 246196012013 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196012014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196012015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196012016 active site 246196012017 phosphorylation site [posttranslational modification] 246196012018 intermolecular recognition site; other site 246196012019 dimerization interface [polypeptide binding]; other site 246196012020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196012021 DNA binding residues [nucleotide binding] 246196012022 Isochorismatase family; Region: Isochorismatase; pfam00857 246196012023 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246196012024 catalytic triad [active] 246196012025 conserved cis-peptide bond; other site 246196012026 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 246196012027 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 246196012028 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 246196012029 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 246196012030 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196012031 classical (c) SDRs; Region: SDR_c; cd05233 246196012032 NAD(P) binding site [chemical binding]; other site 246196012033 active site 246196012034 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196012035 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 246196012036 Transglycosylase; Region: Transgly; pfam00912 246196012037 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 246196012038 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196012039 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196012040 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 246196012041 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196012042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012043 dimer interface [polypeptide binding]; other site 246196012044 conserved gate region; other site 246196012045 putative PBP binding loops; other site 246196012046 ABC-ATPase subunit interface; other site 246196012047 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 246196012048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012049 dimer interface [polypeptide binding]; other site 246196012050 conserved gate region; other site 246196012051 putative PBP binding loops; other site 246196012052 ABC-ATPase subunit interface; other site 246196012053 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196012054 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196012055 Walker A/P-loop; other site 246196012056 ATP binding site [chemical binding]; other site 246196012057 Q-loop/lid; other site 246196012058 ABC transporter signature motif; other site 246196012059 Walker B; other site 246196012060 D-loop; other site 246196012061 H-loop/switch region; other site 246196012062 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 246196012063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196012064 Walker A/P-loop; other site 246196012065 ATP binding site [chemical binding]; other site 246196012066 Q-loop/lid; other site 246196012067 ABC transporter signature motif; other site 246196012068 Walker B; other site 246196012069 D-loop; other site 246196012070 H-loop/switch region; other site 246196012071 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196012072 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196012073 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196012074 active site 246196012075 non-prolyl cis peptide bond; other site 246196012076 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012077 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196012078 active site 246196012079 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196012080 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196012081 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196012082 active site 246196012083 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 246196012084 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196012085 tetramer interface [polypeptide binding]; other site 246196012086 active site 246196012087 Mg2+/Mn2+ binding site [ion binding]; other site 246196012088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196012089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196012090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196012091 dimerization interface [polypeptide binding]; other site 246196012092 Excalibur calcium-binding domain; Region: Excalibur; smart00894 246196012093 Isochorismatase family; Region: Isochorismatase; pfam00857 246196012094 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246196012095 catalytic triad [active] 246196012096 conserved cis-peptide bond; other site 246196012097 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 246196012098 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196012099 DNA binding residues [nucleotide binding] 246196012100 putative dimer interface [polypeptide binding]; other site 246196012101 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196012102 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196012103 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 246196012104 catalytic Zn binding site [ion binding]; other site 246196012105 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 246196012106 structural Zn binding site [ion binding]; other site 246196012107 tetramer interface [polypeptide binding]; other site 246196012108 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 246196012109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196012110 motif II; other site 246196012111 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196012112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196012113 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196012114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196012115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196012116 DNA binding residues [nucleotide binding] 246196012117 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196012118 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196012119 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 246196012120 FAD binding pocket [chemical binding]; other site 246196012121 FAD binding motif [chemical binding]; other site 246196012122 phosphate binding motif [ion binding]; other site 246196012123 beta-alpha-beta structure motif; other site 246196012124 NAD binding pocket [chemical binding]; other site 246196012125 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 246196012126 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 246196012127 Moco binding site; other site 246196012128 metal coordination site [ion binding]; other site 246196012129 Protein of unknown function (DUF421); Region: DUF421; pfam04239 246196012130 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 246196012131 putative active site [active] 246196012132 transaldolase; Provisional; Region: PRK03903 246196012133 catalytic residue [active] 246196012134 methionine sulfoxide reductase A; Provisional; Region: PRK14054 246196012135 methionine sulfoxide reductase B; Provisional; Region: PRK00222 246196012136 SelR domain; Region: SelR; pfam01641 246196012137 classical (c) SDRs; Region: SDR_c; cd05233 246196012138 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196012139 NAD(P) binding site [chemical binding]; other site 246196012140 active site 246196012141 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 246196012142 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 246196012143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196012144 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246196012145 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196012146 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196012147 putative NAD(P) binding site [chemical binding]; other site 246196012148 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 246196012149 homotrimer interaction site [polypeptide binding]; other site 246196012150 putative active site [active] 246196012151 Nitroreductase family; Region: Nitroreductase; pfam00881 246196012152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196012153 putative substrate translocation pore; other site 246196012154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196012155 putative substrate translocation pore; other site 246196012156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196012157 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196012158 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196012159 transcriptional regulator MalT; Provisional; Region: PRK04841 246196012160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246196012161 binding surface 246196012162 TPR motif; other site 246196012163 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246196012164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196012165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196012166 DNA binding residues [nucleotide binding] 246196012167 dimerization interface [polypeptide binding]; other site 246196012168 AAA ATPase domain; Region: AAA_16; pfam13191 246196012169 AAA domain; Region: AAA_22; pfam13401 246196012170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196012171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196012172 DNA binding residues [nucleotide binding] 246196012173 dimerization interface [polypeptide binding]; other site 246196012174 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246196012175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196012176 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 246196012177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196012178 active site 246196012179 motif I; other site 246196012180 motif II; other site 246196012181 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246196012182 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 246196012183 transketolase; Reviewed; Region: PRK05899 246196012184 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 246196012185 TPP-binding site [chemical binding]; other site 246196012186 dimer interface [polypeptide binding]; other site 246196012187 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246196012188 PYR/PP interface [polypeptide binding]; other site 246196012189 dimer interface [polypeptide binding]; other site 246196012190 TPP binding site [chemical binding]; other site 246196012191 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196012192 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 246196012193 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 246196012194 D-pathway; other site 246196012195 Putative ubiquinol binding site [chemical binding]; other site 246196012196 Low-spin heme (heme b) binding site [chemical binding]; other site 246196012197 Putative water exit pathway; other site 246196012198 Binuclear center (heme o3/CuB) [ion binding]; other site 246196012199 K-pathway; other site 246196012200 Putative proton exit pathway; other site 246196012201 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196012202 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196012203 classical (c) SDRs; Region: SDR_c; cd05233 246196012204 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 246196012205 NAD(P) binding site [chemical binding]; other site 246196012206 active site 246196012207 Cupin domain; Region: Cupin_2; cl17218 246196012208 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196012209 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196012210 putative NAD(P) binding site [chemical binding]; other site 246196012211 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 246196012212 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196012213 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246196012214 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 246196012215 PemK-like protein; Region: PemK; pfam02452 246196012216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196012217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196012218 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 246196012219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196012220 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196012221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196012222 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 246196012223 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196012224 catalytic residue [active] 246196012225 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196012226 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196012227 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196012228 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196012229 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 246196012230 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196012231 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 246196012232 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196012233 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 246196012234 Na binding site [ion binding]; other site 246196012235 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 246196012236 agmatinase; Region: agmatinase; TIGR01230 246196012237 oligomer interface [polypeptide binding]; other site 246196012238 putative active site [active] 246196012239 Mn binding site [ion binding]; other site 246196012240 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 246196012241 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196012242 PYR/PP interface [polypeptide binding]; other site 246196012243 dimer interface [polypeptide binding]; other site 246196012244 TPP binding site [chemical binding]; other site 246196012245 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196012246 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 246196012247 TPP-binding site [chemical binding]; other site 246196012248 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 246196012249 Na binding site [ion binding]; other site 246196012250 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 246196012251 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246196012252 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246196012253 Cutinase; Region: Cutinase; pfam01083 246196012254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012255 dimer interface [polypeptide binding]; other site 246196012256 conserved gate region; other site 246196012257 putative PBP binding loops; other site 246196012258 ABC-ATPase subunit interface; other site 246196012259 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196012260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012261 dimer interface [polypeptide binding]; other site 246196012262 conserved gate region; other site 246196012263 putative PBP binding loops; other site 246196012264 ABC-ATPase subunit interface; other site 246196012265 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196012266 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196012267 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 246196012268 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196012269 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 246196012270 Walker A/P-loop; other site 246196012271 ATP binding site [chemical binding]; other site 246196012272 Q-loop/lid; other site 246196012273 ABC transporter signature motif; other site 246196012274 Walker B; other site 246196012275 D-loop; other site 246196012276 H-loop/switch region; other site 246196012277 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196012278 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196012279 Walker A/P-loop; other site 246196012280 ATP binding site [chemical binding]; other site 246196012281 Q-loop/lid; other site 246196012282 ABC transporter signature motif; other site 246196012283 Walker B; other site 246196012284 D-loop; other site 246196012285 H-loop/switch region; other site 246196012286 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196012287 MarR family; Region: MarR; pfam01047 246196012288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196012289 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196012290 putative substrate translocation pore; other site 246196012291 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 246196012292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196012294 active site 246196012295 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 246196012296 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196012297 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 246196012298 cyclase homology domain; Region: CHD; cd07302 246196012299 nucleotidyl binding site; other site 246196012300 metal binding site [ion binding]; metal-binding site 246196012301 dimer interface [polypeptide binding]; other site 246196012302 DNA primase; Validated; Region: dnaG; PRK05667 246196012303 CHC2 zinc finger; Region: zf-CHC2; cl17510 246196012304 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 246196012305 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 246196012306 active site 246196012307 metal binding site [ion binding]; metal-binding site 246196012308 interdomain interaction site; other site 246196012309 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 246196012310 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 246196012311 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 246196012312 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196012313 Zn2+ binding site [ion binding]; other site 246196012314 Mg2+ binding site [ion binding]; other site 246196012315 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 246196012316 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 246196012317 glycyl-tRNA synthetase; Provisional; Region: PRK04173 246196012318 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246196012319 motif 1; other site 246196012320 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 246196012321 active site 246196012322 motif 2; other site 246196012323 motif 3; other site 246196012324 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 246196012325 anticodon binding site; other site 246196012326 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196012327 dimerization interface [polypeptide binding]; other site 246196012328 putative Zn2+ binding site [ion binding]; other site 246196012329 putative DNA binding site [nucleotide binding]; other site 246196012330 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246196012331 metal binding site 2 [ion binding]; metal-binding site 246196012332 putative DNA binding helix; other site 246196012333 metal binding site 1 [ion binding]; metal-binding site 246196012334 dimer interface [polypeptide binding]; other site 246196012335 structural Zn2+ binding site [ion binding]; other site 246196012336 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 246196012337 nudix motif; other site 246196012338 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 246196012339 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 246196012340 catalytic residue [active] 246196012341 putative FPP diphosphate binding site; other site 246196012342 putative FPP binding hydrophobic cleft; other site 246196012343 dimer interface [polypeptide binding]; other site 246196012344 putative IPP diphosphate binding site; other site 246196012345 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 246196012346 Recombination protein O N terminal; Region: RecO_N; pfam11967 246196012347 Recombination protein O C terminal; Region: RecO_C; pfam02565 246196012348 amidase; Provisional; Region: PRK06061 246196012349 Amidase; Region: Amidase; cl11426 246196012350 GTPase Era; Reviewed; Region: era; PRK00089 246196012351 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 246196012352 G1 box; other site 246196012353 GTP/Mg2+ binding site [chemical binding]; other site 246196012354 Switch I region; other site 246196012355 G2 box; other site 246196012356 Switch II region; other site 246196012357 G3 box; other site 246196012358 G4 box; other site 246196012359 G5 box; other site 246196012360 KH domain; Region: KH_2; pfam07650 246196012361 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246196012362 Domain of unknown function DUF21; Region: DUF21; pfam01595 246196012363 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246196012364 Transporter associated domain; Region: CorC_HlyC; smart01091 246196012365 metal-binding heat shock protein; Provisional; Region: PRK00016 246196012366 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 246196012367 PhoH-like protein; Region: PhoH; pfam02562 246196012368 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 246196012369 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 246196012370 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 246196012371 chaperone protein DnaJ; Provisional; Region: PRK14278 246196012372 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246196012373 HSP70 interaction site [polypeptide binding]; other site 246196012374 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 246196012375 Zn binding sites [ion binding]; other site 246196012376 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 246196012377 dimer interface [polypeptide binding]; other site 246196012378 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 246196012379 HTH domain; Region: HTH_11; cl17392 246196012380 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 246196012381 MbtH-like protein; Region: MbtH; pfam03621 246196012382 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 246196012383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196012384 Condensation domain; Region: Condensation; pfam00668 246196012385 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196012386 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196012387 acyl-activating enzyme (AAE) consensus motif; other site 246196012388 AMP binding site [chemical binding]; other site 246196012389 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196012390 Condensation domain; Region: Condensation; pfam00668 246196012391 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196012392 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196012393 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196012394 acyl-activating enzyme (AAE) consensus motif; other site 246196012395 AMP binding site [chemical binding]; other site 246196012396 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196012397 Condensation domain; Region: Condensation; pfam00668 246196012398 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196012399 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196012400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196012401 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196012402 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196012403 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 246196012404 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246196012405 NADP binding site [chemical binding]; other site 246196012406 active site 246196012407 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196012408 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246196012409 active site 246196012410 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 246196012411 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 246196012412 Condensation domain; Region: Condensation; pfam00668 246196012413 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196012414 Nonribosomal peptide synthase; Region: NRPS; pfam08415 246196012415 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 246196012416 acyl-activating enzyme (AAE) consensus motif; other site 246196012417 AMP binding site [chemical binding]; other site 246196012418 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196012419 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 246196012420 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 246196012421 acyl-activating enzyme (AAE) consensus motif; other site 246196012422 active site 246196012423 AMP binding site [chemical binding]; other site 246196012424 substrate binding site [chemical binding]; other site 246196012425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196012426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196012427 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 246196012428 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196012429 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246196012430 Walker A/P-loop; other site 246196012431 ATP binding site [chemical binding]; other site 246196012432 Q-loop/lid; other site 246196012433 ABC transporter signature motif; other site 246196012434 Walker B; other site 246196012435 D-loop; other site 246196012436 H-loop/switch region; other site 246196012437 NMT1-like family; Region: NMT1_2; pfam13379 246196012438 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196012439 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196012440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012441 dimer interface [polypeptide binding]; other site 246196012442 conserved gate region; other site 246196012443 putative PBP binding loops; other site 246196012444 ABC-ATPase subunit interface; other site 246196012445 Winged helix-turn helix; Region: HTH_29; pfam13551 246196012446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196012447 putative DNA binding site [nucleotide binding]; other site 246196012448 dimerization interface [polypeptide binding]; other site 246196012449 putative Zn2+ binding site [ion binding]; other site 246196012450 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196012451 salicylate synthase MbtI; Reviewed; Region: PRK07912 246196012452 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246196012453 coproporphyrinogen III oxidase; Validated; Region: PRK05628 246196012454 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 246196012455 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196012456 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196012457 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 246196012458 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 246196012459 Active Sites [active] 246196012460 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 246196012461 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 246196012462 putative active site [active] 246196012463 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 246196012464 putative active site [active] 246196012465 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 246196012466 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 246196012467 Walker A/P-loop; other site 246196012468 ATP binding site [chemical binding]; other site 246196012469 Q-loop/lid; other site 246196012470 ABC transporter signature motif; other site 246196012471 Walker B; other site 246196012472 D-loop; other site 246196012473 H-loop/switch region; other site 246196012474 TOBE domain; Region: TOBE; pfam03459 246196012475 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246196012476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012477 dimer interface [polypeptide binding]; other site 246196012478 conserved gate region; other site 246196012479 putative PBP binding loops; other site 246196012480 ABC-ATPase subunit interface; other site 246196012481 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246196012482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012483 dimer interface [polypeptide binding]; other site 246196012484 conserved gate region; other site 246196012485 putative PBP binding loops; other site 246196012486 ABC-ATPase subunit interface; other site 246196012487 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246196012488 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 246196012489 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 246196012490 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 246196012491 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246196012492 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 246196012493 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196012494 catalytic residue [active] 246196012495 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 246196012496 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196012497 active site 246196012498 dimer interface [polypeptide binding]; other site 246196012499 non-prolyl cis peptide bond; other site 246196012500 insertion regions; other site 246196012501 hypothetical protein; Provisional; Region: PRK01346 246196012502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196012503 Coenzyme A binding pocket [chemical binding]; other site 246196012504 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196012505 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196012506 Walker A/P-loop; other site 246196012507 ATP binding site [chemical binding]; other site 246196012508 Q-loop/lid; other site 246196012509 ABC transporter signature motif; other site 246196012510 Walker B; other site 246196012511 D-loop; other site 246196012512 H-loop/switch region; other site 246196012513 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196012514 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196012515 Walker A/P-loop; other site 246196012516 ATP binding site [chemical binding]; other site 246196012517 Q-loop/lid; other site 246196012518 ABC transporter signature motif; other site 246196012519 Walker B; other site 246196012520 D-loop; other site 246196012521 H-loop/switch region; other site 246196012522 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196012523 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196012524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012525 dimer interface [polypeptide binding]; other site 246196012526 conserved gate region; other site 246196012527 putative PBP binding loops; other site 246196012528 ABC-ATPase subunit interface; other site 246196012529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196012530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012531 dimer interface [polypeptide binding]; other site 246196012532 conserved gate region; other site 246196012533 putative PBP binding loops; other site 246196012534 ABC-ATPase subunit interface; other site 246196012535 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196012536 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 246196012537 peptide binding site [polypeptide binding]; other site 246196012538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196012539 S-adenosylmethionine binding site [chemical binding]; other site 246196012540 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 246196012541 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196012542 putative NAD(P) binding site [chemical binding]; other site 246196012543 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196012544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012545 active site 246196012546 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196012547 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196012548 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196012549 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196012550 active site 246196012551 non-prolyl cis peptide bond; other site 246196012552 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196012553 active site 246196012554 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196012555 non-prolyl cis peptide bond; other site 246196012556 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012557 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012558 GTP-binding protein LepA; Provisional; Region: PRK05433 246196012559 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 246196012560 G1 box; other site 246196012561 putative GEF interaction site [polypeptide binding]; other site 246196012562 GTP/Mg2+ binding site [chemical binding]; other site 246196012563 Switch I region; other site 246196012564 G2 box; other site 246196012565 G3 box; other site 246196012566 Switch II region; other site 246196012567 G4 box; other site 246196012568 G5 box; other site 246196012569 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 246196012570 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 246196012571 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 246196012572 PemK-like protein; Region: PemK; pfam02452 246196012573 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196012574 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246196012575 Walker A/P-loop; other site 246196012576 ATP binding site [chemical binding]; other site 246196012577 Q-loop/lid; other site 246196012578 ABC transporter signature motif; other site 246196012579 Walker B; other site 246196012580 D-loop; other site 246196012581 H-loop/switch region; other site 246196012582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 246196012583 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 246196012584 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246196012585 dimer interface [polypeptide binding]; other site 246196012586 putative PBP binding regions; other site 246196012587 ABC-ATPase subunit interface; other site 246196012588 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 246196012589 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 246196012590 putative ligand binding residues [chemical binding]; other site 246196012591 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 246196012592 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 246196012593 putative ligand binding residues [chemical binding]; other site 246196012594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196012595 FOG: CBS domain [General function prediction only]; Region: COG0517 246196012596 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 246196012597 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196012598 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196012599 active site 246196012600 catalytic tetrad [active] 246196012601 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196012602 active site 246196012603 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196012604 ribonuclease Z; Reviewed; Region: PRK00055 246196012605 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246196012606 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 246196012607 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246196012608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 246196012609 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 246196012610 Uncharacterized conserved protein [Function unknown]; Region: COG2308 246196012611 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 246196012612 hypothetical protein; Reviewed; Region: PRK07914 246196012613 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 246196012614 Competence protein; Region: Competence; pfam03772 246196012615 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 246196012616 Helix-hairpin-helix motif; Region: HHH; pfam00633 246196012617 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246196012618 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 246196012619 EDD domain protein, DegV family; Region: DegV; TIGR00762 246196012620 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 246196012621 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 246196012622 active site 246196012623 catalytic triad [active] 246196012624 oxyanion hole [active] 246196012625 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196012626 catalytic core [active] 246196012627 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 246196012628 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 246196012629 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 246196012630 active site 246196012631 (T/H)XGH motif; other site 246196012632 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 246196012633 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 246196012634 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196012635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196012636 Walker A motif; other site 246196012637 ATP binding site [chemical binding]; other site 246196012638 Walker B motif; other site 246196012639 arginine finger; other site 246196012640 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 246196012641 putative catalytic cysteine [active] 246196012642 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196012643 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 246196012644 substrate binding site [chemical binding]; other site 246196012645 dimer interface [polypeptide binding]; other site 246196012646 ATP binding site [chemical binding]; other site 246196012647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 246196012648 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196012649 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196012650 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196012651 Walker A/P-loop; other site 246196012652 ATP binding site [chemical binding]; other site 246196012653 Q-loop/lid; other site 246196012654 ABC transporter signature motif; other site 246196012655 Walker B; other site 246196012656 D-loop; other site 246196012657 H-loop/switch region; other site 246196012658 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196012659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012660 dimer interface [polypeptide binding]; other site 246196012661 conserved gate region; other site 246196012662 putative PBP binding loops; other site 246196012663 ABC-ATPase subunit interface; other site 246196012664 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196012665 active site residue [active] 246196012666 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196012667 active site residue [active] 246196012668 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196012669 active site residue [active] 246196012670 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196012671 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196012672 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196012673 active site 246196012674 non-prolyl cis peptide bond; other site 246196012675 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012676 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196012677 active site 246196012678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012679 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012680 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012681 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012682 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196012683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196012684 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196012685 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196012686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196012687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196012688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196012689 dimerization interface [polypeptide binding]; other site 246196012690 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196012691 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 246196012692 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 246196012693 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246196012694 Protein of unknown function (DUF664); Region: DUF664; pfam04978 246196012695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196012696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196012697 ATP binding site [chemical binding]; other site 246196012698 Mg2+ binding site [ion binding]; other site 246196012699 G-X-G motif; other site 246196012700 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 246196012701 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 246196012702 Walker A motif; other site 246196012703 ATP binding site [chemical binding]; other site 246196012704 Walker B motif; other site 246196012705 DNA binding loops [nucleotide binding] 246196012706 replicative DNA helicase; Validated; Region: PRK07773 246196012707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012708 active site 246196012709 NAD synthetase; Reviewed; Region: nadE; PRK02628 246196012710 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 246196012711 multimer interface [polypeptide binding]; other site 246196012712 active site 246196012713 catalytic triad [active] 246196012714 protein interface 1 [polypeptide binding]; other site 246196012715 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 246196012716 homodimer interface [polypeptide binding]; other site 246196012717 NAD binding pocket [chemical binding]; other site 246196012718 ATP binding pocket [chemical binding]; other site 246196012719 Mg binding site [ion binding]; other site 246196012720 active-site loop [active] 246196012721 Isochorismatase family; Region: Isochorismatase; pfam00857 246196012722 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246196012723 catalytic triad [active] 246196012724 conserved cis-peptide bond; other site 246196012725 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 246196012726 NAD-dependent deacetylase; Provisional; Region: PRK05333 246196012727 NAD+ binding site [chemical binding]; other site 246196012728 substrate binding site [chemical binding]; other site 246196012729 Zn binding site [ion binding]; other site 246196012730 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196012731 Cytochrome P450; Region: p450; cl12078 246196012732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196012733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196012734 gamma-glutamyl kinase; Provisional; Region: PRK05429 246196012735 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 246196012736 nucleotide binding site [chemical binding]; other site 246196012737 homotetrameric interface [polypeptide binding]; other site 246196012738 putative phosphate binding site [ion binding]; other site 246196012739 putative allosteric binding site; other site 246196012740 PUA domain; Region: PUA; pfam01472 246196012741 GTPase CgtA; Reviewed; Region: obgE; PRK12296 246196012742 GTP1/OBG; Region: GTP1_OBG; pfam01018 246196012743 Obg GTPase; Region: Obg; cd01898 246196012744 G1 box; other site 246196012745 GTP/Mg2+ binding site [chemical binding]; other site 246196012746 Switch I region; other site 246196012747 G2 box; other site 246196012748 G3 box; other site 246196012749 Switch II region; other site 246196012750 G4 box; other site 246196012751 G5 box; other site 246196012752 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 246196012753 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 246196012754 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 246196012755 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 246196012756 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246196012757 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 246196012758 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 246196012759 homodimer interface [polypeptide binding]; other site 246196012760 oligonucleotide binding site [chemical binding]; other site 246196012761 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 246196012762 active site 246196012763 multimer interface [polypeptide binding]; other site 246196012764 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 246196012765 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 246196012766 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 246196012767 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196012768 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196012769 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 246196012770 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246196012771 active site 246196012772 HIGH motif; other site 246196012773 nucleotide binding site [chemical binding]; other site 246196012774 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246196012775 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 246196012776 active site 246196012777 KMSKS motif; other site 246196012778 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 246196012779 tRNA binding surface [nucleotide binding]; other site 246196012780 anticodon binding site; other site 246196012781 Uncharacterized conserved protein [Function unknown]; Region: COG3268 246196012782 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 246196012783 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196012784 transcription termination factor Rho; Provisional; Region: PRK12678 246196012785 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 246196012786 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 246196012787 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196012788 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196012789 FMN-binding pocket [chemical binding]; other site 246196012790 flavin binding motif; other site 246196012791 phosphate binding motif [ion binding]; other site 246196012792 beta-alpha-beta structure motif; other site 246196012793 NAD binding pocket [chemical binding]; other site 246196012794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196012795 catalytic loop [active] 246196012796 iron binding site [ion binding]; other site 246196012797 hypothetical protein; Provisional; Region: PRK06753 246196012798 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196012799 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 246196012800 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 246196012801 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 246196012802 GTP binding site; other site 246196012803 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 246196012804 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 246196012805 TPP-binding site [chemical binding]; other site 246196012806 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 246196012807 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 246196012808 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246196012809 dimer interface [polypeptide binding]; other site 246196012810 PYR/PP interface [polypeptide binding]; other site 246196012811 TPP binding site [chemical binding]; other site 246196012812 substrate binding site [chemical binding]; other site 246196012813 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246196012814 substrate binding site [chemical binding]; other site 246196012815 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196012816 ATP binding site [chemical binding]; other site 246196012817 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196012818 DNA binding site [nucleotide binding] 246196012819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196012820 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 246196012821 putative ligand binding site [chemical binding]; other site 246196012822 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 246196012823 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196012824 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196012825 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246196012826 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196012827 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 246196012828 Metal-binding active site; metal-binding site 246196012829 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196012830 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196012831 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 246196012832 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196012833 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196012834 active site 246196012835 catalytic tetrad [active] 246196012836 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 246196012837 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246196012838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196012839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196012840 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196012841 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196012842 Walker A/P-loop; other site 246196012843 ATP binding site [chemical binding]; other site 246196012844 ABC transporter signature motif; other site 246196012845 Walker B; other site 246196012846 D-loop; other site 246196012847 H-loop/switch region; other site 246196012848 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196012849 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196012850 TM-ABC transporter signature motif; other site 246196012851 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 246196012852 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 246196012853 putative ligand binding site [chemical binding]; other site 246196012854 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196012855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196012856 DNA-binding site [nucleotide binding]; DNA binding site 246196012857 UTRA domain; Region: UTRA; pfam07702 246196012858 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 246196012859 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196012860 substrate binding site [chemical binding]; other site 246196012861 ATP binding site [chemical binding]; other site 246196012862 KduI/IolB family; Region: KduI; pfam04962 246196012863 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 246196012864 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196012865 PYR/PP interface [polypeptide binding]; other site 246196012866 dimer interface [polypeptide binding]; other site 246196012867 TPP binding site [chemical binding]; other site 246196012868 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196012869 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 246196012870 TPP-binding site; other site 246196012871 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196012872 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196012873 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196012874 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246196012875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196012876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196012877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196012878 dimerization interface [polypeptide binding]; other site 246196012879 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 246196012880 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 246196012881 putative molybdopterin cofactor binding site [chemical binding]; other site 246196012882 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 246196012883 putative molybdopterin cofactor binding site; other site 246196012884 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 246196012885 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196012886 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196012887 active site 246196012888 TDP-binding site; other site 246196012889 acceptor substrate-binding pocket; other site 246196012890 homodimer interface [polypeptide binding]; other site 246196012891 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 246196012892 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 246196012893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196012894 Walker A motif; other site 246196012895 ATP binding site [chemical binding]; other site 246196012896 Walker B motif; other site 246196012897 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246196012898 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 246196012899 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 246196012900 oligomer interface [polypeptide binding]; other site 246196012901 active site residues [active] 246196012902 Clp protease; Region: CLP_protease; pfam00574 246196012903 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 246196012904 oligomer interface [polypeptide binding]; other site 246196012905 active site residues [active] 246196012906 trigger factor; Provisional; Region: tig; PRK01490 246196012907 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246196012908 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 246196012909 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196012910 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196012911 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196012912 GA module; Region: GA; cl08325 246196012913 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 246196012914 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 246196012915 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 246196012916 putative DNA binding site [nucleotide binding]; other site 246196012917 catalytic residue [active] 246196012918 putative H2TH interface [polypeptide binding]; other site 246196012919 putative catalytic residues [active] 246196012920 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246196012921 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246196012922 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 246196012923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196012924 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196012925 active site 246196012926 catalytic tetrad [active] 246196012927 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196012928 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196012929 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196012930 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246196012931 nucleoside/Zn binding site; other site 246196012932 dimer interface [polypeptide binding]; other site 246196012933 catalytic motif [active] 246196012934 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 246196012935 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246196012936 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196012937 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 246196012938 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 246196012939 Zn binding site [ion binding]; other site 246196012940 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196012941 active site 246196012942 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 246196012943 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196012944 active site 246196012945 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 246196012946 apolar tunnel; other site 246196012947 heme binding site [chemical binding]; other site 246196012948 dimerization interface [polypeptide binding]; other site 246196012949 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 246196012950 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 246196012951 active site 246196012952 catalytic site [active] 246196012953 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246196012954 active site 246196012955 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 246196012956 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 246196012957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196012958 Walker A/P-loop; other site 246196012959 ATP binding site [chemical binding]; other site 246196012960 Q-loop/lid; other site 246196012961 ABC transporter signature motif; other site 246196012962 Walker B; other site 246196012963 D-loop; other site 246196012964 H-loop/switch region; other site 246196012965 ABC transporter; Region: ABC_tran_2; pfam12848 246196012966 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196012967 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 246196012968 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 246196012969 dimer interface [polypeptide binding]; other site 246196012970 ssDNA binding site [nucleotide binding]; other site 246196012971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246196012972 Copper resistance protein D; Region: CopD; pfam05425 246196012973 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 246196012974 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 246196012975 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 246196012976 putative acyl-acceptor binding pocket; other site 246196012977 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 246196012978 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 246196012979 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246196012980 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196012981 putative acyl-acceptor binding pocket; other site 246196012982 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196012983 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196012984 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196012985 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196012986 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196012987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196012988 enoyl-CoA hydratase; Provisional; Region: PRK05870 246196012989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196012990 substrate binding site [chemical binding]; other site 246196012991 oxyanion hole (OAH) forming residues; other site 246196012992 trimer interface [polypeptide binding]; other site 246196012993 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 246196012994 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246196012995 E3 interaction surface; other site 246196012996 lipoyl attachment site [posttranslational modification]; other site 246196012997 e3 binding domain; Region: E3_binding; pfam02817 246196012998 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246196012999 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 246196013000 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 246196013001 alpha subunit interface [polypeptide binding]; other site 246196013002 TPP binding site [chemical binding]; other site 246196013003 heterodimer interface [polypeptide binding]; other site 246196013004 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196013005 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 246196013006 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 246196013007 tetramer interface [polypeptide binding]; other site 246196013008 TPP-binding site [chemical binding]; other site 246196013009 heterodimer interface [polypeptide binding]; other site 246196013010 phosphorylation loop region [posttranslational modification] 246196013011 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196013012 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 246196013013 putative active site [active] 246196013014 putative catalytic site [active] 246196013015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013017 active site 246196013018 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 246196013019 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196013020 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196013021 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196013022 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196013023 carboxyltransferase (CT) interaction site; other site 246196013024 biotinylation site [posttranslational modification]; other site 246196013025 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196013026 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 246196013027 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196013028 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 246196013029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013030 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013031 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196013032 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196013033 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 246196013034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013035 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196013036 classical (c) SDRs; Region: SDR_c; cd05233 246196013037 NAD(P) binding site [chemical binding]; other site 246196013038 active site 246196013039 Domain of unknown function DUF87; Region: DUF87; pfam01935 246196013040 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 246196013041 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 246196013042 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 246196013043 catalytic site [active] 246196013044 putative active site [active] 246196013045 putative substrate binding site [chemical binding]; other site 246196013046 dimer interface [polypeptide binding]; other site 246196013047 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246196013048 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196013049 active site 246196013050 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196013051 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246196013052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013053 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 246196013054 Enoylreductase; Region: PKS_ER; smart00829 246196013055 NAD(P) binding site [chemical binding]; other site 246196013056 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246196013057 KR domain; Region: KR; pfam08659 246196013058 putative NADP binding site [chemical binding]; other site 246196013059 active site 246196013060 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196013061 Condensation domain; Region: Condensation; pfam00668 246196013062 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196013063 acyl-CoA synthetase; Validated; Region: PRK05850 246196013064 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196013065 acyl-activating enzyme (AAE) consensus motif; other site 246196013066 active site 246196013067 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246196013068 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246196013069 active site 246196013070 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196013071 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196013072 PE-PPE domain; Region: PE-PPE; pfam08237 246196013073 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246196013074 active site 246196013075 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 246196013076 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 246196013077 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196013078 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 246196013079 Methyltransferase domain; Region: Methyltransf_24; pfam13578 246196013080 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196013081 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196013082 homodimer interface [polypeptide binding]; other site 246196013083 active site 246196013084 TDP-binding site; other site 246196013085 acceptor substrate-binding pocket; other site 246196013086 Transport protein; Region: actII; TIGR00833 246196013087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013088 active site 246196013089 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 246196013090 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 246196013091 putative hydrophobic ligand binding site [chemical binding]; other site 246196013092 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 246196013093 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 246196013094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196013095 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196013096 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 246196013097 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 246196013098 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246196013099 catalytic triad [active] 246196013100 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 246196013101 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246196013102 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246196013103 hypothetical protein; Provisional; Region: PRK07907 246196013104 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 246196013105 active site 246196013106 metal binding site [ion binding]; metal-binding site 246196013107 dimer interface [polypeptide binding]; other site 246196013108 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 246196013109 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246196013110 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 246196013111 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246196013112 phosphate binding site [ion binding]; other site 246196013113 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 246196013114 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 246196013115 putative active site [active] 246196013116 putative catalytic site [active] 246196013117 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246196013118 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246196013119 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 246196013120 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196013121 putative NAD(P) binding site [chemical binding]; other site 246196013122 active site 246196013123 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 246196013124 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246196013125 active site 246196013126 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196013127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196013128 Walker A/P-loop; other site 246196013129 ATP binding site [chemical binding]; other site 246196013130 Q-loop/lid; other site 246196013131 ABC transporter signature motif; other site 246196013132 Walker B; other site 246196013133 D-loop; other site 246196013134 H-loop/switch region; other site 246196013135 TOBE domain; Region: TOBE_2; pfam08402 246196013136 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 246196013137 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246196013138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013139 dimer interface [polypeptide binding]; other site 246196013140 conserved gate region; other site 246196013141 putative PBP binding loops; other site 246196013142 ABC-ATPase subunit interface; other site 246196013143 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196013144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013145 dimer interface [polypeptide binding]; other site 246196013146 conserved gate region; other site 246196013147 putative PBP binding loops; other site 246196013148 ABC-ATPase subunit interface; other site 246196013149 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246196013150 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196013151 DNA binding residues [nucleotide binding] 246196013152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196013154 putative substrate translocation pore; other site 246196013155 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 246196013156 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 246196013157 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 246196013158 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196013159 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 246196013160 acyl-activating enzyme (AAE) consensus motif; other site 246196013161 acyl-activating enzyme (AAE) consensus motif; other site 246196013162 putative AMP binding site [chemical binding]; other site 246196013163 putative active site [active] 246196013164 putative CoA binding site [chemical binding]; other site 246196013165 CoA binding site [chemical binding]; other site 246196013166 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196013167 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196013168 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196013169 acyl-activating enzyme (AAE) consensus motif; other site 246196013170 AMP binding site [chemical binding]; other site 246196013171 active site 246196013172 CoA binding site [chemical binding]; other site 246196013173 enoyl-CoA hydratase; Provisional; Region: PRK06688 246196013174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196013175 substrate binding site [chemical binding]; other site 246196013176 oxyanion hole (OAH) forming residues; other site 246196013177 trimer interface [polypeptide binding]; other site 246196013178 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 246196013179 dimer interface [polypeptide binding]; other site 246196013180 substrate binding site [chemical binding]; other site 246196013181 metal binding site [ion binding]; metal-binding site 246196013182 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 246196013183 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196013184 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 246196013185 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196013186 active site 246196013187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013189 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013190 Cytochrome P450; Region: p450; cl12078 246196013191 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013192 mce related protein; Region: MCE; pfam02470 246196013193 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013194 mce related protein; Region: MCE; pfam02470 246196013195 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196013196 mce related protein; Region: MCE; pfam02470 246196013197 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013198 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196013200 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196013201 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196013202 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196013203 mce related protein; Region: MCE; pfam02470 246196013204 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013205 mce related protein; Region: MCE; pfam02470 246196013206 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013207 mce related protein; Region: MCE; pfam02470 246196013208 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196013209 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196013210 Permease; Region: Permease; pfam02405 246196013211 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196013212 Permease; Region: Permease; pfam02405 246196013213 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013214 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196013215 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 246196013216 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196013217 NAD binding site [chemical binding]; other site 246196013218 catalytic residues [active] 246196013219 acetoin reductases; Region: 23BDH; TIGR02415 246196013220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013221 NAD(P) binding site [chemical binding]; other site 246196013222 active site 246196013223 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196013224 classical (c) SDRs; Region: SDR_c; cd05233 246196013225 NAD(P) binding site [chemical binding]; other site 246196013226 active site 246196013227 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196013228 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013229 Cytochrome P450; Region: p450; cl12078 246196013230 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013231 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013232 active site 246196013233 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 246196013234 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196013235 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196013236 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196013237 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196013238 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196013239 iron-sulfur cluster [ion binding]; other site 246196013240 [2Fe-2S] cluster binding site [ion binding]; other site 246196013241 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196013242 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 246196013243 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 246196013244 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 246196013245 thiolase; Provisional; Region: PRK06158 246196013246 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196013247 active site 246196013248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013249 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196013250 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196013251 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196013252 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196013253 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013254 Cytochrome P450; Region: p450; cl12078 246196013255 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246196013256 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196013257 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196013258 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196013259 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 246196013260 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246196013261 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196013262 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013263 Cytochrome P450; Region: p450; cl12078 246196013264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013266 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013267 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013268 active site 246196013269 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196013270 putative active site [active] 246196013271 putative substrate binding site [chemical binding]; other site 246196013272 ATP binding site [chemical binding]; other site 246196013273 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196013274 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 246196013275 NAD(P) binding site [chemical binding]; other site 246196013276 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013277 Cytochrome P450; Region: p450; cl12078 246196013278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013281 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013282 active site 246196013283 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 246196013284 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196013285 dimer interface [polypeptide binding]; other site 246196013286 active site 246196013287 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013288 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196013289 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196013290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013291 NAD(P) binding site [chemical binding]; other site 246196013292 active site 246196013293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013295 active site 246196013296 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196013297 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196013298 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196013299 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196013300 [2Fe-2S] cluster binding site [ion binding]; other site 246196013301 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 246196013302 alpha subunit interface [polypeptide binding]; other site 246196013303 active site 246196013304 substrate binding site [chemical binding]; other site 246196013305 Fe binding site [ion binding]; other site 246196013306 Herpesvirus VP23 like capsid protein; Region: Herpes_V23; cl17653 246196013307 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196013308 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196013309 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 246196013310 active site 246196013311 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196013312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013313 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 246196013314 active site 246196013315 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013316 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013317 enoyl-CoA hydratase; Provisional; Region: PRK08290 246196013318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196013319 substrate binding site [chemical binding]; other site 246196013320 oxyanion hole (OAH) forming residues; other site 246196013321 trimer interface [polypeptide binding]; other site 246196013322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013324 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196013325 classical (c) SDRs; Region: SDR_c; cd05233 246196013326 NAD(P) binding site [chemical binding]; other site 246196013327 active site 246196013328 classical (c) SDRs; Region: SDR_c; cd05233 246196013329 NAD(P) binding site [chemical binding]; other site 246196013330 active site 246196013331 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013332 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196013333 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013334 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196013335 enoyl-CoA hydratase; Provisional; Region: PRK12478 246196013336 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196013337 substrate binding site [chemical binding]; other site 246196013338 oxyanion hole (OAH) forming residues; other site 246196013339 trimer interface [polypeptide binding]; other site 246196013340 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196013341 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196013342 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246196013343 active site 246196013344 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196013345 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196013346 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246196013347 active site 246196013348 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196013349 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013350 Cytochrome P450; Region: p450; cl12078 246196013351 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246196013352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013353 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196013354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013355 NAD(P) binding site [chemical binding]; other site 246196013356 active site 246196013357 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013358 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196013359 Putative cyclase; Region: Cyclase; pfam04199 246196013360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196013361 NAD(P) binding site [chemical binding]; other site 246196013362 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 246196013363 active site 246196013364 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246196013365 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 246196013366 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 246196013367 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196013368 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 246196013369 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 246196013370 putative active site [active] 246196013371 Fe(II) binding site [ion binding]; other site 246196013372 putative dimer interface [polypeptide binding]; other site 246196013373 putative tetramer interface [polypeptide binding]; other site 246196013374 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 246196013375 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196013376 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196013377 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 246196013378 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 246196013379 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196013380 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 246196013381 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196013382 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 246196013383 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196013384 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 246196013385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013386 NAD(P) binding site [chemical binding]; other site 246196013387 active site 246196013388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013389 NAD(P) binding site [chemical binding]; other site 246196013390 active site 246196013391 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196013392 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196013393 substrate binding site [chemical binding]; other site 246196013394 oxyanion hole (OAH) forming residues; other site 246196013395 trimer interface [polypeptide binding]; other site 246196013396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013397 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013398 active site 246196013399 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013401 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196013402 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196013403 acyl-activating enzyme (AAE) consensus motif; other site 246196013404 AMP binding site [chemical binding]; other site 246196013405 active site 246196013406 CoA binding site [chemical binding]; other site 246196013407 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196013408 catalytic loop [active] 246196013409 iron binding site [ion binding]; other site 246196013410 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013411 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196013412 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 246196013413 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196013414 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 246196013415 B12 binding site [chemical binding]; other site 246196013416 cobalt ligand [ion binding]; other site 246196013417 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 246196013418 short chain dehydrogenase; Provisional; Region: PRK08278 246196013419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013420 NAD(P) binding site [chemical binding]; other site 246196013421 active site 246196013422 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196013423 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196013424 putative AMP binding site [chemical binding]; other site 246196013425 putative active site [active] 246196013426 acyl-activating enzyme (AAE) consensus motif; other site 246196013427 putative CoA binding site [chemical binding]; other site 246196013428 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196013429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013430 Ecdysteroid kinase; Region: EcKinase; cl17738 246196013431 Phosphotransferase enzyme family; Region: APH; pfam01636 246196013432 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013433 Cytochrome P450; Region: p450; cl12078 246196013434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196013435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196013436 DNA binding site [nucleotide binding] 246196013437 domain linker motif; other site 246196013438 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196013439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013440 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196013441 putative substrate translocation pore; other site 246196013442 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 246196013443 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196013444 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246196013445 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 246196013446 dimer interface [polypeptide binding]; other site 246196013447 decamer (pentamer of dimers) interface [polypeptide binding]; other site 246196013448 catalytic triad [active] 246196013449 peroxidatic and resolving cysteines [active] 246196013450 Predicted metalloprotease [General function prediction only]; Region: COG2321 246196013451 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 246196013452 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 246196013453 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 246196013454 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196013455 acyl-activating enzyme (AAE) consensus motif; other site 246196013456 active site 246196013457 Glucitol operon activator protein (GutM); Region: GutM; cl01890 246196013458 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 246196013459 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 246196013460 active site 246196013461 dimerization interface [polypeptide binding]; other site 246196013462 ribonuclease PH; Reviewed; Region: rph; PRK00173 246196013463 Ribonuclease PH; Region: RNase_PH_bact; cd11362 246196013464 hexamer interface [polypeptide binding]; other site 246196013465 active site 246196013466 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 246196013467 glutamate racemase; Provisional; Region: PRK00865 246196013468 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 246196013469 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 246196013470 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246196013471 dimer interface [polypeptide binding]; other site 246196013472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196013473 catalytic residue [active] 246196013474 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 246196013475 MoaE interaction surface [polypeptide binding]; other site 246196013476 MoeB interaction surface [polypeptide binding]; other site 246196013477 thiocarboxylated glycine; other site 246196013478 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 246196013479 MPN+ (JAMM) motif; other site 246196013480 Zinc-binding site [ion binding]; other site 246196013481 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 246196013482 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 246196013483 cleavage site 246196013484 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 246196013485 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 246196013486 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 246196013487 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 246196013488 active site 246196013489 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 246196013490 DEAD/DEAH box helicase; Region: DEAD; pfam00270 246196013491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196013492 putative Mg++ binding site [ion binding]; other site 246196013493 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 246196013494 Predicted metalloprotease [General function prediction only]; Region: COG2321 246196013495 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 246196013496 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246196013497 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 246196013498 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 246196013499 putative homodimer interface [polypeptide binding]; other site 246196013500 putative active site pocket [active] 246196013501 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 246196013502 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 246196013503 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 246196013504 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 246196013505 active site 246196013506 homodimer interface [polypeptide binding]; other site 246196013507 catalytic site [active] 246196013508 acceptor binding site [chemical binding]; other site 246196013509 glycogen branching enzyme; Provisional; Region: PRK05402 246196013510 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 246196013511 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 246196013512 active site 246196013513 catalytic site [active] 246196013514 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 246196013515 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 246196013516 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 246196013517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196013518 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 246196013519 putative acyltransferase; Provisional; Region: PRK05790 246196013520 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196013521 dimer interface [polypeptide binding]; other site 246196013522 active site 246196013523 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 246196013524 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196013525 dimer interface [polypeptide binding]; other site 246196013526 substrate binding site [chemical binding]; other site 246196013527 metal binding site [ion binding]; metal-binding site 246196013528 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 246196013529 hypothetical protein; Provisional; Region: PRK03298 246196013530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196013531 dimerization interface [polypeptide binding]; other site 246196013532 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196013533 cyclase homology domain; Region: CHD; cd07302 246196013534 nucleotidyl binding site; other site 246196013535 metal binding site [ion binding]; metal-binding site 246196013536 dimer interface [polypeptide binding]; other site 246196013537 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 246196013538 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 246196013539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196013540 AlkA N-terminal domain; Region: AlkA_N; pfam06029 246196013541 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 246196013542 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246196013543 minor groove reading motif; other site 246196013544 helix-hairpin-helix signature motif; other site 246196013545 substrate binding pocket [chemical binding]; other site 246196013546 active site 246196013547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196013548 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196013549 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196013550 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 246196013551 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 246196013552 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246196013553 DNA binding site [nucleotide binding] 246196013554 active site 246196013555 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 246196013556 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 246196013557 hinge; other site 246196013558 active site 246196013559 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 246196013560 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 246196013561 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 246196013562 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 246196013563 gamma subunit interface [polypeptide binding]; other site 246196013564 epsilon subunit interface [polypeptide binding]; other site 246196013565 LBP interface [polypeptide binding]; other site 246196013566 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 246196013567 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246196013568 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 246196013569 alpha subunit interaction interface [polypeptide binding]; other site 246196013570 Walker A motif; other site 246196013571 ATP binding site [chemical binding]; other site 246196013572 Walker B motif; other site 246196013573 inhibitor binding site; inhibition site 246196013574 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 246196013575 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 246196013576 core domain interface [polypeptide binding]; other site 246196013577 delta subunit interface [polypeptide binding]; other site 246196013578 epsilon subunit interface [polypeptide binding]; other site 246196013579 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 246196013580 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246196013581 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 246196013582 beta subunit interaction interface [polypeptide binding]; other site 246196013583 Walker A motif; other site 246196013584 ATP binding site [chemical binding]; other site 246196013585 Walker B motif; other site 246196013586 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 246196013587 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 246196013588 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 246196013589 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 246196013590 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 246196013591 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 246196013592 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 246196013593 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 246196013594 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 246196013595 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196013596 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 246196013597 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 246196013598 Mg++ binding site [ion binding]; other site 246196013599 putative catalytic motif [active] 246196013600 substrate binding site [chemical binding]; other site 246196013601 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 246196013602 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 246196013603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196013604 S-adenosylmethionine binding site [chemical binding]; other site 246196013605 peptide chain release factor 1; Validated; Region: prfA; PRK00591 246196013606 This domain is found in peptide chain release factors; Region: PCRF; smart00937 246196013607 RF-1 domain; Region: RF-1; pfam00472 246196013608 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 246196013609 acyl-CoA synthetase; Provisional; Region: PRK13388 246196013610 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196013611 acyl-activating enzyme (AAE) consensus motif; other site 246196013612 AMP binding site [chemical binding]; other site 246196013613 active site 246196013614 CoA binding site [chemical binding]; other site 246196013615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013617 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 246196013618 transcription termination factor Rho; Provisional; Region: PRK12608 246196013619 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246196013620 RNA binding site [nucleotide binding]; other site 246196013621 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 246196013622 multimer interface [polypeptide binding]; other site 246196013623 Walker A motif; other site 246196013624 ATP binding site [chemical binding]; other site 246196013625 Walker B motif; other site 246196013626 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 246196013627 threonine synthase; Reviewed; Region: PRK06721 246196013628 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 246196013629 homodimer interface [polypeptide binding]; other site 246196013630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196013631 catalytic residue [active] 246196013632 homoserine dehydrogenase; Provisional; Region: PRK06349 246196013633 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 246196013634 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 246196013635 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 246196013636 diaminopimelate decarboxylase; Region: lysA; TIGR01048 246196013637 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 246196013638 active site 246196013639 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196013640 substrate binding site [chemical binding]; other site 246196013641 catalytic residues [active] 246196013642 dimer interface [polypeptide binding]; other site 246196013643 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 246196013644 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 246196013645 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 246196013646 active site 246196013647 HIGH motif; other site 246196013648 KMSK motif region; other site 246196013649 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 246196013650 tRNA binding surface [nucleotide binding]; other site 246196013651 anticodon binding site; other site 246196013652 Condensation domain; Region: Condensation; pfam00668 246196013653 hypothetical protein; Provisional; Region: PRK06185 246196013654 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246196013655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013657 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 246196013658 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196013659 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196013660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196013661 Histidine kinase; Region: HisKA_3; pfam07730 246196013662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196013663 ATP binding site [chemical binding]; other site 246196013664 Mg2+ binding site [ion binding]; other site 246196013665 G-X-G motif; other site 246196013666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196013667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196013668 active site 246196013669 phosphorylation site [posttranslational modification] 246196013670 intermolecular recognition site; other site 246196013671 dimerization interface [polypeptide binding]; other site 246196013672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196013673 DNA binding residues [nucleotide binding] 246196013674 dimerization interface [polypeptide binding]; other site 246196013675 Nitronate monooxygenase; Region: NMO; pfam03060 246196013676 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196013677 FMN binding site [chemical binding]; other site 246196013678 substrate binding site [chemical binding]; other site 246196013679 putative catalytic residue [active] 246196013680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196013681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196013682 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 246196013683 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196013684 metal binding site [ion binding]; metal-binding site 246196013685 Rrf2 family protein; Region: rrf2_super; TIGR00738 246196013686 Transcriptional regulator; Region: Rrf2; pfam02082 246196013687 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 246196013688 Isochorismatase family; Region: Isochorismatase; pfam00857 246196013689 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 246196013690 catalytic triad [active] 246196013691 conserved cis-peptide bond; other site 246196013692 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 246196013693 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 246196013694 active site 246196013695 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 246196013696 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 246196013697 CysD dimerization site [polypeptide binding]; other site 246196013698 G1 box; other site 246196013699 putative GEF interaction site [polypeptide binding]; other site 246196013700 GTP/Mg2+ binding site [chemical binding]; other site 246196013701 Switch I region; other site 246196013702 G2 box; other site 246196013703 G3 box; other site 246196013704 Switch II region; other site 246196013705 G4 box; other site 246196013706 G5 box; other site 246196013707 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 246196013708 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 246196013709 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 246196013710 ligand-binding site [chemical binding]; other site 246196013711 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 246196013712 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 246196013713 Active Sites [active] 246196013714 putative transporter; Provisional; Region: PRK10504 246196013715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013716 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196013717 Phosphotransferase enzyme family; Region: APH; pfam01636 246196013718 putative active site [active] 246196013719 putative substrate binding site [chemical binding]; other site 246196013720 ATP binding site [chemical binding]; other site 246196013721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013722 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196013723 CoenzymeA binding site [chemical binding]; other site 246196013724 subunit interaction site [polypeptide binding]; other site 246196013725 PHB binding site; other site 246196013726 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 246196013727 active site clefts [active] 246196013728 zinc binding site [ion binding]; other site 246196013729 dimer interface [polypeptide binding]; other site 246196013730 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 246196013731 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246196013732 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196013733 active site 246196013734 GtrA-like protein; Region: GtrA; pfam04138 246196013735 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246196013736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196013737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 246196013738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196013739 dimer interface [polypeptide binding]; other site 246196013740 phosphorylation site [posttranslational modification] 246196013741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196013742 ATP binding site [chemical binding]; other site 246196013743 Mg2+ binding site [ion binding]; other site 246196013744 G-X-G motif; other site 246196013745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196013746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196013747 active site 246196013748 phosphorylation site [posttranslational modification] 246196013749 intermolecular recognition site; other site 246196013750 dimerization interface [polypeptide binding]; other site 246196013751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196013752 DNA binding site [nucleotide binding] 246196013753 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196013754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013755 putative PBP binding loops; other site 246196013756 dimer interface [polypeptide binding]; other site 246196013757 ABC-ATPase subunit interface; other site 246196013758 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196013759 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 246196013760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013761 dimer interface [polypeptide binding]; other site 246196013762 conserved gate region; other site 246196013763 putative PBP binding loops; other site 246196013764 ABC-ATPase subunit interface; other site 246196013765 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 246196013766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196013767 Walker A/P-loop; other site 246196013768 ATP binding site [chemical binding]; other site 246196013769 Q-loop/lid; other site 246196013770 ABC transporter signature motif; other site 246196013771 Walker B; other site 246196013772 D-loop; other site 246196013773 H-loop/switch region; other site 246196013774 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196013775 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196013776 Walker A/P-loop; other site 246196013777 ATP binding site [chemical binding]; other site 246196013778 Q-loop/lid; other site 246196013779 ABC transporter signature motif; other site 246196013780 Walker B; other site 246196013781 D-loop; other site 246196013782 H-loop/switch region; other site 246196013783 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 246196013784 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 246196013785 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 246196013786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013787 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196013788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013789 active site 246196013790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196013791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196013792 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 246196013793 putative substrate binding pocket [chemical binding]; other site 246196013794 putative dimerization interface [polypeptide binding]; other site 246196013795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196013796 S-adenosylmethionine binding site [chemical binding]; other site 246196013797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196013798 Walker A/P-loop; other site 246196013799 ATP binding site [chemical binding]; other site 246196013800 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 246196013801 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 246196013802 active site 246196013803 metal binding site [ion binding]; metal-binding site 246196013804 DNA binding site [nucleotide binding] 246196013805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196013806 catalytic core [active] 246196013807 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196013808 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196013809 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196013810 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196013811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196013812 Walker A/P-loop; other site 246196013813 ATP binding site [chemical binding]; other site 246196013814 Q-loop/lid; other site 246196013815 ABC transporter signature motif; other site 246196013816 Walker B; other site 246196013817 D-loop; other site 246196013818 H-loop/switch region; other site 246196013819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196013820 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 246196013821 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 246196013822 Walker A/P-loop; other site 246196013823 ATP binding site [chemical binding]; other site 246196013824 Q-loop/lid; other site 246196013825 ABC transporter signature motif; other site 246196013826 Walker B; other site 246196013827 D-loop; other site 246196013828 H-loop/switch region; other site 246196013829 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 246196013830 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 246196013831 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246196013832 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246196013833 metal-binding site [ion binding] 246196013834 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196013835 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 246196013836 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246196013837 metal-binding site [ion binding] 246196013838 Domain of unknown function (DUF305); Region: DUF305; pfam03713 246196013839 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196013840 cyclase homology domain; Region: CHD; cd07302 246196013841 nucleotidyl binding site; other site 246196013842 metal binding site [ion binding]; metal-binding site 246196013843 dimer interface [polypeptide binding]; other site 246196013844 GAF domain; Region: GAF; pfam01590 246196013845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013846 acetoin reductases; Region: 23BDH; TIGR02415 246196013847 NAD(P) binding site [chemical binding]; other site 246196013848 active site 246196013849 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196013850 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 246196013851 putative NAD(P) binding site [chemical binding]; other site 246196013852 catalytic Zn binding site [ion binding]; other site 246196013853 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196013854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196013855 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246196013856 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 246196013857 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 246196013858 putative active site [active] 246196013859 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196013860 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196013861 active site 246196013862 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196013863 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 246196013864 putative dimer interface [polypeptide binding]; other site 246196013865 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196013866 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 246196013867 HIT family signature motif; other site 246196013868 catalytic residue [active] 246196013869 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196013870 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 246196013871 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196013872 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 246196013873 Fe-S cluster binding site [ion binding]; other site 246196013874 DNA binding site [nucleotide binding] 246196013875 active site 246196013876 potential frameshift: common BLAST hit: gi|120405413|ref|YP_955242.1| H+ antiporter protein 246196013877 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196013878 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196013879 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196013880 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196013881 SCP-2 sterol transfer family; Region: SCP2; cl01225 246196013882 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196013883 TIGR03086 family protein; Region: TIGR03086 246196013884 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 246196013885 FAD binding domain; Region: FAD_binding_4; pfam01565 246196013886 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246196013887 Rhomboid family; Region: Rhomboid; pfam01694 246196013888 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013889 Cytochrome P450; Region: p450; cl12078 246196013890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013892 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 246196013893 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246196013894 FAD binding pocket [chemical binding]; other site 246196013895 FAD binding motif [chemical binding]; other site 246196013896 phosphate binding motif [ion binding]; other site 246196013897 NAD binding pocket [chemical binding]; other site 246196013898 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196013899 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 246196013900 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 246196013901 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246196013902 ATP binding site [chemical binding]; other site 246196013903 Mg++ binding site [ion binding]; other site 246196013904 motif III; other site 246196013905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196013906 nucleotide binding region [chemical binding]; other site 246196013907 ATP-binding site [chemical binding]; other site 246196013908 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 246196013909 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 246196013910 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 246196013911 RNase_H superfamily; Region: RNase_H_2; pfam13482 246196013912 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 246196013913 Part of AAA domain; Region: AAA_19; pfam13245 246196013914 AAA domain; Region: AAA_12; pfam13087 246196013915 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196013916 FAD binding domain; Region: FAD_binding_4; pfam01565 246196013917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196013919 putative substrate translocation pore; other site 246196013920 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 246196013921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013922 putative substrate translocation pore; other site 246196013923 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 246196013924 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246196013925 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 246196013926 TPP-binding site [chemical binding]; other site 246196013927 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 246196013928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013929 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196013930 putative substrate translocation pore; other site 246196013931 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246196013932 active site 246196013933 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196013934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196013935 sequence-specific DNA binding site [nucleotide binding]; other site 246196013936 salt bridge; other site 246196013937 short chain dehydrogenase; Provisional; Region: PRK06181 246196013938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013939 NAD(P) binding site [chemical binding]; other site 246196013940 active site 246196013941 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 246196013942 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 246196013943 Malic enzyme, N-terminal domain; Region: malic; pfam00390 246196013944 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 246196013945 NAD(P) binding pocket [chemical binding]; other site 246196013946 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 246196013947 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 246196013948 oligomer interface [polypeptide binding]; other site 246196013949 metal binding site [ion binding]; metal-binding site 246196013950 metal binding site [ion binding]; metal-binding site 246196013951 putative Cl binding site [ion binding]; other site 246196013952 basic sphincter; other site 246196013953 hydrophobic gate; other site 246196013954 periplasmic entrance; other site 246196013955 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 246196013956 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196013957 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246196013958 Walker A/P-loop; other site 246196013959 ATP binding site [chemical binding]; other site 246196013960 Q-loop/lid; other site 246196013961 ABC transporter signature motif; other site 246196013962 Walker B; other site 246196013963 D-loop; other site 246196013964 H-loop/switch region; other site 246196013965 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196013966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013967 dimer interface [polypeptide binding]; other site 246196013968 conserved gate region; other site 246196013969 putative PBP binding loops; other site 246196013970 ABC-ATPase subunit interface; other site 246196013971 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196013972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013973 dimer interface [polypeptide binding]; other site 246196013974 conserved gate region; other site 246196013975 putative PBP binding loops; other site 246196013976 ABC-ATPase subunit interface; other site 246196013977 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196013978 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196013979 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 246196013980 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196013981 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 246196013982 MgtE intracellular N domain; Region: MgtE_N; smart00924 246196013983 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 246196013984 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 246196013985 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 246196013986 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246196013987 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246196013988 Domain of unknown function DUF59; Region: DUF59; cl00941 246196013989 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 246196013990 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 246196013991 sec-independent translocase; Provisional; Region: PRK03100 246196013992 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246196013993 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246196013994 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 246196013995 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 246196013996 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196013997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196013998 DNA binding residues [nucleotide binding] 246196013999 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 246196014000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014001 S-adenosylmethionine binding site [chemical binding]; other site 246196014002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014004 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196014005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196014006 Walker A/P-loop; other site 246196014007 ATP binding site [chemical binding]; other site 246196014008 Q-loop/lid; other site 246196014009 ABC transporter signature motif; other site 246196014010 Walker B; other site 246196014011 D-loop; other site 246196014012 H-loop/switch region; other site 246196014013 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 246196014014 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 246196014015 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 246196014016 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 246196014017 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 246196014018 ligand binding site; other site 246196014019 oligomer interface; other site 246196014020 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 246196014021 dimer interface [polypeptide binding]; other site 246196014022 N-terminal domain interface [polypeptide binding]; other site 246196014023 sulfate 1 binding site; other site 246196014024 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 246196014025 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196014026 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 246196014027 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 246196014028 DivIVA domain; Region: DivI1A_domain; TIGR03544 246196014029 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 246196014030 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246196014031 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 246196014032 dihydropteroate synthase; Region: DHPS; TIGR01496 246196014033 substrate binding pocket [chemical binding]; other site 246196014034 dimer interface [polypeptide binding]; other site 246196014035 inhibitor binding site; inhibition site 246196014036 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 246196014037 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 246196014038 acyl-activating enzyme (AAE) consensus motif; other site 246196014039 putative AMP binding site [chemical binding]; other site 246196014040 putative active site [active] 246196014041 putative CoA binding site [chemical binding]; other site 246196014042 TIGR00730 family protein; Region: TIGR00730 246196014043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246196014044 TPR motif; other site 246196014045 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196014046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196014047 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196014048 putative transposase OrfB; Reviewed; Region: PHA02517 246196014049 HTH-like domain; Region: HTH_21; pfam13276 246196014050 Integrase core domain; Region: rve; pfam00665 246196014051 Integrase core domain; Region: rve_3; pfam13683 246196014052 Transposase; Region: HTH_Tnp_1; cl17663 246196014053 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196014054 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 246196014055 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246196014056 dimer interface [polypeptide binding]; other site 246196014057 PYR/PP interface [polypeptide binding]; other site 246196014058 TPP binding site [chemical binding]; other site 246196014059 substrate binding site [chemical binding]; other site 246196014060 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 246196014061 TPP-binding site; other site 246196014062 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 246196014063 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246196014064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196014065 Walker A/P-loop; other site 246196014066 ATP binding site [chemical binding]; other site 246196014067 Q-loop/lid; other site 246196014068 ABC transporter signature motif; other site 246196014069 Walker B; other site 246196014070 D-loop; other site 246196014071 H-loop/switch region; other site 246196014072 ABC transporter; Region: ABC_tran_2; pfam12848 246196014073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196014074 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 246196014075 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 246196014076 metal binding site [ion binding]; metal-binding site 246196014077 putative dimer interface [polypeptide binding]; other site 246196014078 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 246196014079 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 246196014080 putative trimer interface [polypeptide binding]; other site 246196014081 putative CoA binding site [chemical binding]; other site 246196014082 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 246196014083 SnoaL-like domain; Region: SnoaL_3; pfam13474 246196014084 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196014085 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196014086 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196014087 active site 246196014088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196014089 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196014090 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246196014091 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196014092 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196014093 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 246196014094 acyl-CoA synthetase; Validated; Region: PRK07787 246196014095 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196014096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196014097 acyl-activating enzyme (AAE) consensus motif; other site 246196014098 acyl-activating enzyme (AAE) consensus motif; other site 246196014099 AMP binding site [chemical binding]; other site 246196014100 active site 246196014101 CoA binding site [chemical binding]; other site 246196014102 Domain of unknown function (DUF309); Region: DUF309; pfam03745 246196014103 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 246196014104 dimer interface [polypeptide binding]; other site 246196014105 active site 246196014106 ADP-ribose binding site [chemical binding]; other site 246196014107 nudix motif; other site 246196014108 metal binding site [ion binding]; metal-binding site 246196014109 Proline dehydrogenase; Region: Pro_dh; cl03282 246196014110 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 246196014111 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 246196014112 Glutamate binding site [chemical binding]; other site 246196014113 NAD binding site [chemical binding]; other site 246196014114 catalytic residues [active] 246196014115 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196014116 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196014117 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 246196014118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196014119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196014120 homodimer interface [polypeptide binding]; other site 246196014121 catalytic residue [active] 246196014122 Ferredoxin [Energy production and conversion]; Region: COG1146 246196014123 4Fe-4S binding domain; Region: Fer4; pfam00037 246196014124 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196014125 active site 246196014126 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196014127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196014128 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 246196014129 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 246196014130 active site 246196014131 FMN binding site [chemical binding]; other site 246196014132 2,4-decadienoyl-CoA binding site; other site 246196014133 catalytic residue [active] 246196014134 4Fe-4S cluster binding site [ion binding]; other site 246196014135 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 246196014136 Uncharacterized conserved protein [Function unknown]; Region: COG2353 246196014137 FO synthase; Reviewed; Region: fbiC; PRK09234 246196014138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196014139 FeS/SAM binding site; other site 246196014140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196014141 FeS/SAM binding site; other site 246196014142 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 246196014143 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 246196014144 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 246196014145 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 246196014146 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 246196014147 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 246196014148 G1 box; other site 246196014149 putative GEF interaction site [polypeptide binding]; other site 246196014150 GTP/Mg2+ binding site [chemical binding]; other site 246196014151 Switch I region; other site 246196014152 G2 box; other site 246196014153 G3 box; other site 246196014154 Switch II region; other site 246196014155 G4 box; other site 246196014156 G5 box; other site 246196014157 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 246196014158 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 246196014159 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 246196014160 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 246196014161 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 246196014162 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 246196014163 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 246196014164 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 246196014165 [4Fe-4S] binding site [ion binding]; other site 246196014166 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196014167 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196014168 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196014169 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 246196014170 molybdopterin cofactor binding site; other site 246196014171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014172 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 246196014173 putative substrate translocation pore; other site 246196014174 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 246196014175 beta-galactosidase; Region: BGL; TIGR03356 246196014176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196014177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196014178 DNA binding site [nucleotide binding] 246196014179 domain linker motif; other site 246196014180 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 246196014181 putative dimerization interface [polypeptide binding]; other site 246196014182 putative ligand binding site [chemical binding]; other site 246196014183 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 246196014184 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 246196014185 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 246196014186 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 246196014187 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196014188 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 246196014189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014190 dimer interface [polypeptide binding]; other site 246196014191 conserved gate region; other site 246196014192 putative PBP binding loops; other site 246196014193 ABC-ATPase subunit interface; other site 246196014194 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196014195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014196 dimer interface [polypeptide binding]; other site 246196014197 conserved gate region; other site 246196014198 putative PBP binding loops; other site 246196014199 ABC-ATPase subunit interface; other site 246196014200 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 246196014201 active site 246196014202 8-oxo-dGMP binding site [chemical binding]; other site 246196014203 nudix motif; other site 246196014204 metal binding site [ion binding]; metal-binding site 246196014205 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 246196014206 aromatic arch; other site 246196014207 DCoH dimer interaction site [polypeptide binding]; other site 246196014208 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 246196014209 DCoH tetramer interaction site [polypeptide binding]; other site 246196014210 substrate binding site [chemical binding]; other site 246196014211 mannosyltransferase; Provisional; Region: pimE; PRK13375 246196014212 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 246196014213 FMN binding site [chemical binding]; other site 246196014214 Nitroreductase family; Region: Nitroreductase; pfam00881 246196014215 dimer interface [polypeptide binding]; other site 246196014216 uncharacterized HhH-GPD family protein; Region: TIGR03252 246196014217 minor groove reading motif; other site 246196014218 helix-hairpin-helix signature motif; other site 246196014219 Histidine kinase; Region: His_kinase; pfam06580 246196014220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014221 ATP binding site [chemical binding]; other site 246196014222 Mg2+ binding site [ion binding]; other site 246196014223 G-X-G motif; other site 246196014224 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 246196014225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014226 active site 246196014227 phosphorylation site [posttranslational modification] 246196014228 intermolecular recognition site; other site 246196014229 dimerization interface [polypeptide binding]; other site 246196014230 LytTr DNA-binding domain; Region: LytTR; smart00850 246196014231 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196014232 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196014233 Na binding site [ion binding]; other site 246196014234 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196014235 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196014236 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 246196014237 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 246196014238 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 246196014239 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 246196014240 putative NAD(P) binding site [chemical binding]; other site 246196014241 dimer interface [polypeptide binding]; other site 246196014242 Protein of unknown function, DUF485; Region: DUF485; pfam04341 246196014243 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 246196014244 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 246196014245 Na binding site [ion binding]; other site 246196014246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196014247 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246196014248 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196014249 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196014250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196014251 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 246196014252 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196014253 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 246196014254 Predicted transcriptional regulators [Transcription]; Region: COG1725 246196014255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196014256 DNA-binding site [nucleotide binding]; DNA binding site 246196014257 NAD-dependent deacetylase; Provisional; Region: PRK00481 246196014258 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 246196014259 NAD+ binding site [chemical binding]; other site 246196014260 substrate binding site [chemical binding]; other site 246196014261 Zn binding site [ion binding]; other site 246196014262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014263 S-adenosylmethionine binding site [chemical binding]; other site 246196014264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014266 WHG domain; Region: WHG; pfam13305 246196014267 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196014268 Predicted membrane protein [Function unknown]; Region: COG2259 246196014269 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196014270 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 246196014271 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196014272 FMN binding site [chemical binding]; other site 246196014273 substrate binding site [chemical binding]; other site 246196014274 putative catalytic residue [active] 246196014275 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 246196014276 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 246196014277 NAD binding site [chemical binding]; other site 246196014278 homodimer interface [polypeptide binding]; other site 246196014279 homotetramer interface [polypeptide binding]; other site 246196014280 active site 246196014281 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196014282 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196014283 enoyl-CoA hydratase; Provisional; Region: PRK06688 246196014284 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014285 substrate binding site [chemical binding]; other site 246196014286 oxyanion hole (OAH) forming residues; other site 246196014287 trimer interface [polypeptide binding]; other site 246196014288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 246196014289 HicB family; Region: HicB; pfam05534 246196014290 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196014291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014292 CAAX protease self-immunity; Region: Abi; pfam02517 246196014293 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196014294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196014295 NAD(P) binding site [chemical binding]; other site 246196014296 active site 246196014297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196014300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196014301 active site 246196014302 catalytic tetrad [active] 246196014303 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 246196014304 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 246196014305 trimer interface [polypeptide binding]; other site 246196014306 putative metal binding site [ion binding]; other site 246196014307 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 246196014308 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196014309 conserved cys residue [active] 246196014310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196014311 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196014312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196014313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014314 putative substrate translocation pore; other site 246196014315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014316 Fasciclin domain; Region: Fasciclin; pfam02469 246196014317 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196014318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196014319 active site 246196014320 enoyl-CoA hydratase; Provisional; Region: PRK08252 246196014321 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014322 substrate binding site [chemical binding]; other site 246196014323 oxyanion hole (OAH) forming residues; other site 246196014324 trimer interface [polypeptide binding]; other site 246196014325 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 246196014326 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196014327 dimer interface [polypeptide binding]; other site 246196014328 active site 246196014329 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196014330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196014331 FCD domain; Region: FCD; pfam07729 246196014332 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 246196014333 Predicted membrane protein [Function unknown]; Region: COG2259 246196014334 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 246196014335 classical (c) SDRs; Region: SDR_c; cd05233 246196014336 NAD(P) binding site [chemical binding]; other site 246196014337 active site 246196014338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014340 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196014341 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196014342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196014343 hypothetical protein; Provisional; Region: PRK06149 246196014344 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196014345 inhibitor-cofactor binding pocket; inhibition site 246196014346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196014347 catalytic residue [active] 246196014348 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196014349 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 246196014350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196014351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196014352 DNA binding residues [nucleotide binding] 246196014353 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 246196014354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196014355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196014356 active site 246196014357 metal binding site [ion binding]; metal-binding site 246196014358 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196014359 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246196014360 RibD C-terminal domain; Region: RibD_C; cl17279 246196014361 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196014362 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196014363 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196014364 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246196014365 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196014366 GTP-binding protein YchF; Reviewed; Region: PRK09601 246196014367 YchF GTPase; Region: YchF; cd01900 246196014368 G1 box; other site 246196014369 GTP/Mg2+ binding site [chemical binding]; other site 246196014370 Switch I region; other site 246196014371 G2 box; other site 246196014372 Switch II region; other site 246196014373 G3 box; other site 246196014374 G4 box; other site 246196014375 G5 box; other site 246196014376 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 246196014377 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 246196014378 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 246196014379 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 246196014380 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 246196014381 generic binding surface II; other site 246196014382 generic binding surface I; other site 246196014383 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 246196014384 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 246196014385 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 246196014386 putative NAD(P) binding site [chemical binding]; other site 246196014387 active site 246196014388 putative substrate binding site [chemical binding]; other site 246196014389 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 246196014390 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 246196014391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196014392 extended (e) SDRs; Region: SDR_e; cd08946 246196014393 NAD(P) binding site [chemical binding]; other site 246196014394 active site 246196014395 substrate binding site [chemical binding]; other site 246196014396 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246196014397 classical (c) SDRs; Region: SDR_c; cd05233 246196014398 NAD(P) binding site [chemical binding]; other site 246196014399 active site 246196014400 short chain dehydrogenase; Provisional; Region: PRK07825 246196014401 classical (c) SDRs; Region: SDR_c; cd05233 246196014402 NAD(P) binding site [chemical binding]; other site 246196014403 active site 246196014404 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246196014405 Domain of unknown function DUF20; Region: UPF0118; pfam01594 246196014406 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246196014407 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 246196014408 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 246196014409 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 246196014410 putative active site [active] 246196014411 fumarate hydratase; Reviewed; Region: fumC; PRK00485 246196014412 Class II fumarases; Region: Fumarase_classII; cd01362 246196014413 active site 246196014414 tetramer interface [polypeptide binding]; other site 246196014415 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196014416 GAF domain; Region: GAF; pfam01590 246196014417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196014418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014419 ATP binding site [chemical binding]; other site 246196014420 Mg2+ binding site [ion binding]; other site 246196014421 G-X-G motif; other site 246196014422 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196014423 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196014424 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 246196014425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196014426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014427 active site 246196014428 phosphorylation site [posttranslational modification] 246196014429 intermolecular recognition site; other site 246196014430 dimerization interface [polypeptide binding]; other site 246196014431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196014432 DNA binding residues [nucleotide binding] 246196014433 dimerization interface [polypeptide binding]; other site 246196014434 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196014435 Ligand Binding Site [chemical binding]; other site 246196014436 Universal stress protein family; Region: Usp; pfam00582 246196014437 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196014438 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 246196014439 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 246196014440 putative active site [active] 246196014441 PhoH-like protein; Region: PhoH; pfam02562 246196014442 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 246196014443 dinuclear metal binding motif [ion binding]; other site 246196014444 serine hydroxymethyltransferase; Provisional; Region: PRK13580 246196014445 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 246196014446 dimer interface [polypeptide binding]; other site 246196014447 active site 246196014448 glycine-pyridoxal phosphate binding site [chemical binding]; other site 246196014449 folate binding site [chemical binding]; other site 246196014450 pantothenate kinase; Provisional; Region: PRK05439 246196014451 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 246196014452 ATP-binding site [chemical binding]; other site 246196014453 CoA-binding site [chemical binding]; other site 246196014454 Mg2+-binding site [ion binding]; other site 246196014455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196014456 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 246196014457 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 246196014458 catalytic residue [active] 246196014459 putative FPP diphosphate binding site; other site 246196014460 putative FPP binding hydrophobic cleft; other site 246196014461 dimer interface [polypeptide binding]; other site 246196014462 putative IPP diphosphate binding site; other site 246196014463 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 246196014464 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 246196014465 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196014466 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 246196014467 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 246196014468 catalytic residues [active] 246196014469 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 246196014470 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 246196014471 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 246196014472 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 246196014473 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246196014474 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 246196014475 cystathionine gamma-synthase; Provisional; Region: PRK07811 246196014476 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246196014477 homodimer interface [polypeptide binding]; other site 246196014478 substrate-cofactor binding pocket; other site 246196014479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196014480 catalytic residue [active] 246196014481 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196014482 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196014483 active site 246196014484 RDD family; Region: RDD; pfam06271 246196014485 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 246196014486 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246196014487 dimer interface [polypeptide binding]; other site 246196014488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196014489 catalytic residue [active] 246196014490 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 246196014491 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 246196014492 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 246196014493 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196014494 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 246196014495 active site 246196014496 catalytic triad [active] 246196014497 oxyanion hole [active] 246196014498 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 246196014499 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196014500 dimer interface [polypeptide binding]; other site 246196014501 active site 246196014502 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 246196014503 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 246196014504 ATP-grasp domain; Region: ATP-grasp; pfam02222 246196014505 Bax inhibitor 1 like; Region: BaxI_1; cl17691 246196014506 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 246196014507 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 246196014508 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014509 substrate binding site [chemical binding]; other site 246196014510 oxyanion hole (OAH) forming residues; other site 246196014511 trimer interface [polypeptide binding]; other site 246196014512 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 246196014513 enoyl-CoA hydratase; Provisional; Region: PRK05862 246196014514 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014515 substrate binding site [chemical binding]; other site 246196014516 oxyanion hole (OAH) forming residues; other site 246196014517 trimer interface [polypeptide binding]; other site 246196014518 Predicted membrane protein [Function unknown]; Region: COG4425 246196014519 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 246196014520 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196014521 active site residue [active] 246196014522 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 246196014523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014525 Predicted acyl esterases [General function prediction only]; Region: COG2936 246196014526 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 246196014527 hypothetical protein; Provisional; Region: PRK10279 246196014528 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 246196014529 active site 246196014530 nucleophile elbow; other site 246196014531 Patatin-like phospholipase; Region: Patatin; pfam01734 246196014532 nucleophile elbow; other site 246196014533 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196014534 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 246196014535 putative NAD(P) binding site [chemical binding]; other site 246196014536 catalytic Zn binding site [ion binding]; other site 246196014537 structural Zn binding site [ion binding]; other site 246196014538 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196014539 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246196014540 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246196014541 DNA binding residues [nucleotide binding] 246196014542 AAA ATPase domain; Region: AAA_16; pfam13191 246196014543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 246196014544 PAS domain; Region: PAS_9; pfam13426 246196014545 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196014546 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 246196014547 dimer interface [polypeptide binding]; other site 246196014548 acyl-activating enzyme (AAE) consensus motif; other site 246196014549 putative active site [active] 246196014550 AMP binding site [chemical binding]; other site 246196014551 putative CoA binding site [chemical binding]; other site 246196014552 acyl-CoA synthetase; Validated; Region: PRK05852 246196014553 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196014554 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196014555 acyl-activating enzyme (AAE) consensus motif; other site 246196014556 acyl-activating enzyme (AAE) consensus motif; other site 246196014557 AMP binding site [chemical binding]; other site 246196014558 active site 246196014559 CoA binding site [chemical binding]; other site 246196014560 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 246196014561 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196014562 PYR/PP interface [polypeptide binding]; other site 246196014563 dimer interface [polypeptide binding]; other site 246196014564 TPP binding site [chemical binding]; other site 246196014565 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196014566 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 246196014567 TPP-binding site; other site 246196014568 dimer interface [polypeptide binding]; other site 246196014569 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196014570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196014571 NAD(P) binding site [chemical binding]; other site 246196014572 active site 246196014573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014575 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 246196014576 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 246196014577 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 246196014578 Na binding site [ion binding]; other site 246196014579 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 246196014580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014581 ATP binding site [chemical binding]; other site 246196014582 Mg2+ binding site [ion binding]; other site 246196014583 G-X-G motif; other site 246196014584 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 246196014585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014586 active site 246196014587 phosphorylation site [posttranslational modification] 246196014588 intermolecular recognition site; other site 246196014589 dimerization interface [polypeptide binding]; other site 246196014590 HTH domain; Region: HTH_11; cl17392 246196014591 choline dehydrogenase; Validated; Region: PRK02106 246196014592 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246196014593 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196014594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014596 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 246196014597 Predicted transcriptional regulator [Transcription]; Region: COG2345 246196014598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196014599 dimerization interface [polypeptide binding]; other site 246196014600 putative DNA binding site [nucleotide binding]; other site 246196014601 putative Zn2+ binding site [ion binding]; other site 246196014602 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196014603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014604 S-adenosylmethionine binding site [chemical binding]; other site 246196014605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196014606 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 246196014607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196014608 Walker A/P-loop; other site 246196014609 ATP binding site [chemical binding]; other site 246196014610 Q-loop/lid; other site 246196014611 ABC transporter signature motif; other site 246196014612 Walker B; other site 246196014613 D-loop; other site 246196014614 H-loop/switch region; other site 246196014615 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196014616 putative active site [active] 246196014617 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 246196014618 amidase catalytic site [active] 246196014619 Zn binding residues [ion binding]; other site 246196014620 substrate binding site [chemical binding]; other site 246196014621 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246196014622 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 246196014623 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196014624 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196014625 Walker A/P-loop; other site 246196014626 ATP binding site [chemical binding]; other site 246196014627 Q-loop/lid; other site 246196014628 ABC transporter signature motif; other site 246196014629 Walker B; other site 246196014630 D-loop; other site 246196014631 H-loop/switch region; other site 246196014632 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196014633 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196014634 substrate binding pocket [chemical binding]; other site 246196014635 membrane-bound complex binding site; other site 246196014636 hinge residues; other site 246196014637 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246196014638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014639 dimer interface [polypeptide binding]; other site 246196014640 conserved gate region; other site 246196014641 putative PBP binding loops; other site 246196014642 ABC-ATPase subunit interface; other site 246196014643 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196014644 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196014645 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 246196014646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 246196014647 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 246196014648 Predicted membrane protein [Function unknown]; Region: COG2119 246196014649 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 246196014650 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 246196014651 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 246196014652 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 246196014653 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196014654 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196014655 homodimer interface [polypeptide binding]; other site 246196014656 active site 246196014657 TDP-binding site; other site 246196014658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014659 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246196014660 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 246196014661 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 246196014662 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 246196014663 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196014664 MarR family; Region: MarR_2; cl17246 246196014665 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 246196014666 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 246196014667 putative ligand binding site [chemical binding]; other site 246196014668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196014669 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 246196014670 active site 246196014671 catalytic residues [active] 246196014672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014675 D-galactonate transporter; Region: 2A0114; TIGR00893 246196014676 putative substrate translocation pore; other site 246196014677 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196014678 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196014679 acyl-activating enzyme (AAE) consensus motif; other site 246196014680 AMP binding site [chemical binding]; other site 246196014681 active site 246196014682 CoA binding site [chemical binding]; other site 246196014683 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196014684 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196014685 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196014686 PE-PPE domain; Region: PE-PPE; pfam08237 246196014687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196014688 Coenzyme A binding pocket [chemical binding]; other site 246196014689 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196014690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014691 S-adenosylmethionine binding site [chemical binding]; other site 246196014692 O-methyltransferase; Region: Methyltransf_2; pfam00891 246196014693 Excalibur calcium-binding domain; Region: Excalibur; cl05460 246196014694 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 246196014695 cyanate hydratase; Validated; Region: PRK02866 246196014696 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 246196014697 oligomer interface [polypeptide binding]; other site 246196014698 active site 246196014699 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 246196014700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196014701 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 246196014702 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196014703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196014704 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 246196014705 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196014706 substrate binding pocket [chemical binding]; other site 246196014707 membrane-bound complex binding site; other site 246196014708 hinge residues; other site 246196014709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014710 dimer interface [polypeptide binding]; other site 246196014711 conserved gate region; other site 246196014712 putative PBP binding loops; other site 246196014713 ABC-ATPase subunit interface; other site 246196014714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014715 dimer interface [polypeptide binding]; other site 246196014716 conserved gate region; other site 246196014717 putative PBP binding loops; other site 246196014718 ABC-ATPase subunit interface; other site 246196014719 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196014720 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196014721 Walker A/P-loop; other site 246196014722 ATP binding site [chemical binding]; other site 246196014723 Q-loop/lid; other site 246196014724 ABC transporter signature motif; other site 246196014725 Walker B; other site 246196014726 D-loop; other site 246196014727 H-loop/switch region; other site 246196014728 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 246196014729 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 246196014730 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 246196014731 Ligand Binding Site [chemical binding]; other site 246196014732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014733 ATP binding site [chemical binding]; other site 246196014734 Mg2+ binding site [ion binding]; other site 246196014735 G-X-G motif; other site 246196014736 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196014737 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 246196014738 putative active site [active] 246196014739 catalytic triad [active] 246196014740 putative dimer interface [polypeptide binding]; other site 246196014741 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196014742 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196014743 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196014744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196014745 DNA-binding site [nucleotide binding]; DNA binding site 246196014746 FCD domain; Region: FCD; pfam07729 246196014747 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196014748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196014749 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196014750 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196014751 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196014752 classical (c) SDRs; Region: SDR_c; cd05233 246196014753 NAD(P) binding site [chemical binding]; other site 246196014754 active site 246196014755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246196014756 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196014757 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196014758 active site residue [active] 246196014759 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196014760 active site residue [active] 246196014761 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196014762 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 246196014763 putative homotetramer interface [polypeptide binding]; other site 246196014764 putative homodimer interface [polypeptide binding]; other site 246196014765 putative allosteric switch controlling residues; other site 246196014766 putative metal binding site [ion binding]; other site 246196014767 putative homodimer-homodimer interface [polypeptide binding]; other site 246196014768 Domain of unknown function DUF302; Region: DUF302; cl01364 246196014769 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 246196014770 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 246196014771 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196014772 Soluble P-type ATPase [General function prediction only]; Region: COG4087 246196014773 K+-transporting ATPase, c chain; Region: KdpC; cl00944 246196014774 K+-transporting ATPase, c chain; Region: KdpC; cl00944 246196014775 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 246196014776 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 246196014777 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 246196014778 Ligand Binding Site [chemical binding]; other site 246196014779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196014780 dimer interface [polypeptide binding]; other site 246196014781 phosphorylation site [posttranslational modification] 246196014782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014783 ATP binding site [chemical binding]; other site 246196014784 Mg2+ binding site [ion binding]; other site 246196014785 G-X-G motif; other site 246196014786 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 246196014787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014788 active site 246196014789 phosphorylation site [posttranslational modification] 246196014790 intermolecular recognition site; other site 246196014791 dimerization interface [polypeptide binding]; other site 246196014792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196014793 DNA binding site [nucleotide binding] 246196014794 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 246196014795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196014796 nucleotide binding region [chemical binding]; other site 246196014797 ATP-binding site [chemical binding]; other site 246196014798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196014799 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196014800 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 246196014801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196014802 ATP binding site [chemical binding]; other site 246196014803 putative Mg++ binding site [ion binding]; other site 246196014804 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246196014805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196014806 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 246196014807 hydrophobic ligand binding site; other site 246196014808 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196014809 classical (c) SDRs; Region: SDR_c; cd05233 246196014810 NAD(P) binding site [chemical binding]; other site 246196014811 active site 246196014812 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 246196014813 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 246196014814 acyl-activating enzyme (AAE) consensus motif; other site 246196014815 putative AMP binding site [chemical binding]; other site 246196014816 putative active site [active] 246196014817 putative CoA binding site [chemical binding]; other site 246196014818 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 246196014819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196014820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 246196014821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196014822 dimerization interface [polypeptide binding]; other site 246196014823 putative DNA binding site [nucleotide binding]; other site 246196014824 putative Zn2+ binding site [ion binding]; other site 246196014825 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 246196014826 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 246196014827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196014828 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246196014829 FeS/SAM binding site; other site 246196014830 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 246196014831 exopolyphosphatase; Region: exo_poly_only; TIGR03706 246196014832 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 246196014833 Uncharacterized conserved protein [Function unknown]; Region: COG1507 246196014834 enolase; Provisional; Region: eno; PRK00077 246196014835 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 246196014836 dimer interface [polypeptide binding]; other site 246196014837 metal binding site [ion binding]; metal-binding site 246196014838 substrate binding pocket [chemical binding]; other site 246196014839 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 246196014840 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246196014841 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246196014842 Iron permease FTR1 family; Region: FTR1; cl00475 246196014843 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 246196014844 Imelysin; Region: Peptidase_M75; pfam09375 246196014845 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 246196014846 PE-PPE domain; Region: PE-PPE; pfam08237 246196014847 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 246196014848 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 246196014849 homodimer interface [polypeptide binding]; other site 246196014850 metal binding site [ion binding]; metal-binding site 246196014851 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 246196014852 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 246196014853 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196014854 ATP binding site [chemical binding]; other site 246196014855 putative Mg++ binding site [ion binding]; other site 246196014856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196014857 nucleotide binding region [chemical binding]; other site 246196014858 ATP-binding site [chemical binding]; other site 246196014859 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 246196014860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014862 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 246196014863 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 246196014864 Substrate binding site; other site 246196014865 Mg++ binding site; other site 246196014866 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 246196014867 active site 246196014868 substrate binding site [chemical binding]; other site 246196014869 CoA binding site [chemical binding]; other site 246196014870 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 246196014871 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 246196014872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196014873 active site 246196014874 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 246196014875 ArsC family; Region: ArsC; pfam03960 246196014876 catalytic residues [active] 246196014877 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 246196014878 short chain dehydrogenase; Provisional; Region: PRK06197 246196014879 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 246196014880 putative NAD(P) binding site [chemical binding]; other site 246196014881 active site 246196014882 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 246196014883 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 246196014884 5S rRNA interface [nucleotide binding]; other site 246196014885 CTC domain interface [polypeptide binding]; other site 246196014886 L16 interface [polypeptide binding]; other site 246196014887 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 246196014888 putative active site [active] 246196014889 catalytic residue [active] 246196014890 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 246196014891 4Fe-4S binding domain; Region: Fer4; pfam00037 246196014892 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 246196014893 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196014894 acyl-activating enzyme (AAE) consensus motif; other site 246196014895 AMP binding site [chemical binding]; other site 246196014896 active site 246196014897 CoA binding site [chemical binding]; other site 246196014898 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 246196014899 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 246196014900 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 246196014901 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196014902 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196014903 active site 246196014904 ATP binding site [chemical binding]; other site 246196014905 substrate binding site [chemical binding]; other site 246196014906 activation loop (A-loop); other site 246196014907 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196014908 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 246196014909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014910 S-adenosylmethionine binding site [chemical binding]; other site 246196014911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 246196014912 Domain of unknown function (DUF348); Region: DUF348; pfam03990 246196014913 Domain of unknown function (DUF348); Region: DUF348; pfam03990 246196014914 Domain of unknown function (DUF348); Region: DUF348; pfam03990 246196014915 G5 domain; Region: G5; pfam07501 246196014916 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 246196014917 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 246196014918 active site 246196014919 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 246196014920 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 246196014921 active site 246196014922 HIGH motif; other site 246196014923 KMSKS motif; other site 246196014924 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 246196014925 tRNA binding surface [nucleotide binding]; other site 246196014926 anticodon binding site; other site 246196014927 glutamate dehydrogenase; Provisional; Region: PRK09414 246196014928 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 246196014929 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 246196014930 NAD(P) binding site [chemical binding]; other site 246196014931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 246196014932 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 246196014933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196014934 DNA binding residues [nucleotide binding] 246196014935 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196014936 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 246196014937 chorismate binding enzyme; Region: Chorismate_bind; cl10555 246196014938 Predicted methyltransferases [General function prediction only]; Region: COG0313 246196014939 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 246196014940 putative SAM binding site [chemical binding]; other site 246196014941 putative homodimer interface [polypeptide binding]; other site 246196014942 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 246196014943 arginine deiminase; Provisional; Region: PRK01388 246196014944 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 246196014945 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 246196014946 DNA binding residues [nucleotide binding] 246196014947 dimer interface [polypeptide binding]; other site 246196014948 [2Fe-2S] cluster binding site [ion binding]; other site 246196014949 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 246196014950 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 246196014951 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 246196014952 PE-PPE domain; Region: PE-PPE; pfam08237 246196014953 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 246196014954 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 246196014955 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 246196014956 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 246196014957 shikimate binding site; other site 246196014958 NAD(P) binding site [chemical binding]; other site 246196014959 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196014960 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196014961 ligand binding site [chemical binding]; other site 246196014962 flexible hinge region; other site 246196014963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196014964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 246196014965 Predicted permeases [General function prediction only]; Region: RarD; COG2962 246196014966 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196014967 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196014968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196014969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014970 putative substrate translocation pore; other site 246196014971 glucose-1-dehydrogenase; Provisional; Region: PRK06947 246196014972 classical (c) SDRs; Region: SDR_c; cd05233 246196014973 NAD(P) binding site [chemical binding]; other site 246196014974 active site 246196014975 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 246196014976 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246196014977 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246196014978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196014979 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 246196014980 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246196014981 dimer interface [polypeptide binding]; other site 246196014982 putative functional site; other site 246196014983 putative MPT binding site; other site 246196014984 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 246196014985 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 246196014986 active site 246196014987 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 246196014988 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 246196014989 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 246196014990 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196014991 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196014992 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196014993 glyoxylate carboligase; Provisional; Region: PRK11269 246196014994 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196014995 PYR/PP interface [polypeptide binding]; other site 246196014996 dimer interface [polypeptide binding]; other site 246196014997 TPP binding site [chemical binding]; other site 246196014998 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196014999 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196015000 TPP-binding site [chemical binding]; other site 246196015001 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196015002 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196015003 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 246196015004 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 246196015005 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 246196015006 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 246196015007 MspA; Region: MspA; pfam09203 246196015008 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 246196015009 MPT binding site; other site 246196015010 trimer interface [polypeptide binding]; other site 246196015011 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246196015012 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246196015013 protein binding site [polypeptide binding]; other site 246196015014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196015015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196015016 dimerization interface [polypeptide binding]; other site 246196015017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196015018 dimer interface [polypeptide binding]; other site 246196015019 phosphorylation site [posttranslational modification] 246196015020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196015021 ATP binding site [chemical binding]; other site 246196015022 Mg2+ binding site [ion binding]; other site 246196015023 G-X-G motif; other site 246196015024 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196015025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196015026 active site 246196015027 phosphorylation site [posttranslational modification] 246196015028 intermolecular recognition site; other site 246196015029 dimerization interface [polypeptide binding]; other site 246196015030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196015031 DNA binding site [nucleotide binding] 246196015032 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 246196015033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196015034 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015035 active site 246196015036 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196015037 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196015038 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 246196015039 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196015040 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196015041 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196015042 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196015043 carboxyltransferase (CT) interaction site; other site 246196015044 biotinylation site [posttranslational modification]; other site 246196015045 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 246196015046 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196015047 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196015048 active site 246196015049 enoyl-CoA hydratase; Provisional; Region: PRK07827 246196015050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015051 substrate binding site [chemical binding]; other site 246196015052 oxyanion hole (OAH) forming residues; other site 246196015053 trimer interface [polypeptide binding]; other site 246196015054 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 246196015055 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246196015056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246196015057 PE-PPE domain; Region: PE-PPE; pfam08237 246196015058 PE-PPE domain; Region: PE-PPE; pfam08237 246196015059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015060 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196015061 NAD(P) binding site [chemical binding]; other site 246196015062 active site 246196015063 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196015064 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 246196015065 PhoD-like phosphatase; Region: PhoD; pfam09423 246196015066 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 246196015067 putative active site [active] 246196015068 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246196015069 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246196015070 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 246196015071 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246196015072 metal ion-dependent adhesion site (MIDAS); other site 246196015073 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 246196015074 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 246196015075 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196015076 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196015077 active site 246196015078 ATP binding site [chemical binding]; other site 246196015079 substrate binding site [chemical binding]; other site 246196015080 activation loop (A-loop); other site 246196015081 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 246196015082 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 246196015083 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 246196015084 purine monophosphate binding site [chemical binding]; other site 246196015085 dimer interface [polypeptide binding]; other site 246196015086 putative catalytic residues [active] 246196015087 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 246196015088 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 246196015089 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 246196015090 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 246196015091 active site 246196015092 cosubstrate binding site; other site 246196015093 substrate binding site [chemical binding]; other site 246196015094 catalytic site [active] 246196015095 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 246196015096 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196015097 active site 246196015098 dimer interface [polypeptide binding]; other site 246196015099 non-prolyl cis peptide bond; other site 246196015100 insertion regions; other site 246196015101 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196015102 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196015103 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 246196015104 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196015105 active site 246196015106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015108 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 246196015109 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196015110 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 246196015111 CoA binding domain; Region: CoA_binding; smart00881 246196015112 CoA-ligase; Region: Ligase_CoA; pfam00549 246196015113 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 246196015114 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 246196015115 CoA-ligase; Region: Ligase_CoA; pfam00549 246196015116 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246196015117 Peptidase family M23; Region: Peptidase_M23; pfam01551 246196015118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 246196015119 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196015120 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196015121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015122 dimer interface [polypeptide binding]; other site 246196015123 conserved gate region; other site 246196015124 putative PBP binding loops; other site 246196015125 ABC-ATPase subunit interface; other site 246196015126 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196015127 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196015128 Walker A/P-loop; other site 246196015129 ATP binding site [chemical binding]; other site 246196015130 Q-loop/lid; other site 246196015131 ABC transporter signature motif; other site 246196015132 Walker B; other site 246196015133 D-loop; other site 246196015134 H-loop/switch region; other site 246196015135 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 246196015136 Ferredoxin [Energy production and conversion]; Region: COG1146 246196015137 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246196015138 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 246196015139 Part of AAA domain; Region: AAA_19; pfam13245 246196015140 Family description; Region: UvrD_C_2; pfam13538 246196015141 hypothetical protein; Provisional; Region: PRK07857 246196015142 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196015143 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196015144 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 246196015145 active site 246196015146 catalytic triad [active] 246196015147 oxyanion hole [active] 246196015148 succinic semialdehyde dehydrogenase; Region: PLN02278 246196015149 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 246196015150 tetramerization interface [polypeptide binding]; other site 246196015151 NAD(P) binding site [chemical binding]; other site 246196015152 catalytic residues [active] 246196015153 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 246196015154 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 246196015155 active site 246196015156 dimer interface [polypeptide binding]; other site 246196015157 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 246196015158 dimer interface [polypeptide binding]; other site 246196015159 active site 246196015160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196015161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196015162 non-specific DNA binding site [nucleotide binding]; other site 246196015163 salt bridge; other site 246196015164 sequence-specific DNA binding site [nucleotide binding]; other site 246196015165 short chain dehydrogenase; Provisional; Region: PRK08251 246196015166 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 246196015167 putative NAD(P) binding site [chemical binding]; other site 246196015168 active site 246196015169 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 246196015170 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 246196015171 putative DNA binding site [nucleotide binding]; other site 246196015172 catalytic residue [active] 246196015173 putative H2TH interface [polypeptide binding]; other site 246196015174 putative catalytic residues [active] 246196015175 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246196015176 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246196015177 Predicted membrane protein [Function unknown]; Region: COG1289 246196015178 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246196015179 Predicted membrane protein [Function unknown]; Region: COG1950 246196015180 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 246196015181 active site 246196015182 SAM binding site [chemical binding]; other site 246196015183 homodimer interface [polypeptide binding]; other site 246196015184 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 246196015185 potential frameshift: common BLAST hit: gi|120404184|ref|YP_954013.1| CheB methylesterase 246196015186 CheB methylesterase; Region: CheB_methylest; pfam01339 246196015187 CheB methylesterase; Region: CheB_methylest; pfam01339 246196015188 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246196015189 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246196015190 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 246196015191 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 246196015192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196015193 PAS domain; Region: PAS_9; pfam13426 246196015194 putative active site [active] 246196015195 heme pocket [chemical binding]; other site 246196015196 PAS domain; Region: PAS_9; pfam13426 246196015197 GAF domain; Region: GAF; pfam01590 246196015198 GAF domain; Region: GAF_2; pfam13185 246196015199 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 246196015200 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196015201 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196015202 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 246196015203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015204 putative substrate translocation pore; other site 246196015205 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 246196015206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015208 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 246196015209 RNA/DNA hybrid binding site [nucleotide binding]; other site 246196015210 active site 246196015211 HPP family; Region: HPP; pfam04982 246196015212 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 246196015213 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196015214 conserved cys residue [active] 246196015215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196015216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196015217 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 246196015218 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246196015219 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 246196015220 heme-binding site [chemical binding]; other site 246196015221 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015222 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 246196015223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015226 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 246196015227 NAD(P) binding site [chemical binding]; other site 246196015228 active site 246196015229 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196015230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015231 NAD(P) binding site [chemical binding]; other site 246196015232 active site 246196015233 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 246196015234 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 246196015235 nucleotide binding site [chemical binding]; other site 246196015236 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 246196015237 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 246196015238 active site 246196015239 DNA binding site [nucleotide binding] 246196015240 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 246196015241 DNA binding site [nucleotide binding] 246196015242 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196015243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015244 Walker A/P-loop; other site 246196015245 ATP binding site [chemical binding]; other site 246196015246 Q-loop/lid; other site 246196015247 ABC transporter signature motif; other site 246196015248 Walker B; other site 246196015249 D-loop; other site 246196015250 H-loop/switch region; other site 246196015251 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196015252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015253 dimer interface [polypeptide binding]; other site 246196015254 conserved gate region; other site 246196015255 putative PBP binding loops; other site 246196015256 ABC-ATPase subunit interface; other site 246196015257 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196015258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015259 conserved gate region; other site 246196015260 dimer interface [polypeptide binding]; other site 246196015261 putative PBP binding loops; other site 246196015262 ABC-ATPase subunit interface; other site 246196015263 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196015264 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196015265 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196015266 MarR family; Region: MarR_2; pfam12802 246196015267 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196015268 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 246196015269 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 246196015270 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 246196015271 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 246196015272 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196015273 putative substrate binding site [chemical binding]; other site 246196015274 putative ATP binding site [chemical binding]; other site 246196015275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015276 putative DNA binding site [nucleotide binding]; other site 246196015277 putative Zn2+ binding site [ion binding]; other site 246196015278 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 246196015279 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 246196015280 putative DNA binding site [nucleotide binding]; other site 246196015281 putative homodimer interface [polypeptide binding]; other site 246196015282 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 246196015283 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 246196015284 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196015285 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196015286 active site 246196015287 short chain dehydrogenase; Provisional; Region: PRK07814 246196015288 classical (c) SDRs; Region: SDR_c; cd05233 246196015289 NAD(P) binding site [chemical binding]; other site 246196015290 active site 246196015291 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196015292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196015293 manganese transport protein MntH; Reviewed; Region: PRK00701 246196015294 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 246196015295 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 246196015296 putative active site pocket [active] 246196015297 dimerization interface [polypeptide binding]; other site 246196015298 putative catalytic residue [active] 246196015299 Protein of unknown function (DUF867); Region: DUF867; pfam05908 246196015300 carboxylate-amine ligase; Provisional; Region: PRK13517 246196015301 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 246196015302 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 246196015303 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196015304 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246196015305 iron-sulfur cluster [ion binding]; other site 246196015306 [2Fe-2S] cluster binding site [ion binding]; other site 246196015307 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 246196015308 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246196015309 PYR/PP interface [polypeptide binding]; other site 246196015310 tetramer interface [polypeptide binding]; other site 246196015311 dimer interface [polypeptide binding]; other site 246196015312 TPP binding site [chemical binding]; other site 246196015313 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196015314 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196015315 TPP-binding site [chemical binding]; other site 246196015316 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196015317 iron-sulfur cluster [ion binding]; other site 246196015318 [2Fe-2S] cluster binding site [ion binding]; other site 246196015319 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246196015320 active site 246196015321 FMN binding site [chemical binding]; other site 246196015322 substrate binding site [chemical binding]; other site 246196015323 3Fe-4S cluster binding site [ion binding]; other site 246196015324 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196015325 MarR family; Region: MarR_2; pfam12802 246196015326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015327 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196015328 NAD(P) binding site [chemical binding]; other site 246196015329 active site 246196015330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015332 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 246196015333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015334 dimerization interface [polypeptide binding]; other site 246196015335 putative DNA binding site [nucleotide binding]; other site 246196015336 putative Zn2+ binding site [ion binding]; other site 246196015337 Cation efflux family; Region: Cation_efflux; cl00316 246196015338 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 246196015339 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 246196015340 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 246196015341 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 246196015342 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196015343 active site 246196015344 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 246196015345 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 246196015346 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196015347 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196015348 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196015349 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196015350 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246196015351 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246196015352 putative dimer interface [polypeptide binding]; other site 246196015353 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246196015354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196015355 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 246196015356 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 246196015357 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246196015358 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246196015359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196015360 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 246196015361 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196015362 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196015363 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015364 active site 246196015365 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196015366 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015367 active site 246196015368 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196015369 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015370 substrate binding site [chemical binding]; other site 246196015371 oxyanion hole (OAH) forming residues; other site 246196015372 trimer interface [polypeptide binding]; other site 246196015373 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 246196015374 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196015375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015376 active site 246196015377 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196015378 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196015379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015380 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196015381 NAD(P) binding site [chemical binding]; other site 246196015382 active site 246196015383 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196015384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196015385 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 246196015386 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196015387 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246196015388 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196015389 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196015390 [2Fe-2S] cluster binding site [ion binding]; other site 246196015391 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246196015392 hydrophobic ligand binding site; other site 246196015393 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246196015394 classical (c) SDRs; Region: SDR_c; cd05233 246196015395 NAD(P) binding site [chemical binding]; other site 246196015396 active site 246196015397 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196015398 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196015399 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246196015400 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196015401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196015402 DNA-binding site [nucleotide binding]; DNA binding site 246196015403 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 246196015404 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 246196015405 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 246196015406 acyl-activating enzyme (AAE) consensus motif; other site 246196015407 putative AMP binding site [chemical binding]; other site 246196015408 putative active site [active] 246196015409 putative CoA binding site [chemical binding]; other site 246196015410 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 246196015411 classical (c) SDRs; Region: SDR_c; cd05233 246196015412 NAD(P) binding site [chemical binding]; other site 246196015413 active site 246196015414 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196015415 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196015416 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196015417 acyl-activating enzyme (AAE) consensus motif; other site 246196015418 acyl-activating enzyme (AAE) consensus motif; other site 246196015419 putative AMP binding site [chemical binding]; other site 246196015420 putative active site [active] 246196015421 putative CoA binding site [chemical binding]; other site 246196015422 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 246196015423 hydrophobic ligand binding site; other site 246196015424 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 246196015425 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 246196015426 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196015427 Soluble P-type ATPase [General function prediction only]; Region: COG4087 246196015428 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196015429 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196015430 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 246196015431 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196015432 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246196015433 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196015434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015435 substrate binding site [chemical binding]; other site 246196015436 oxyanion hole (OAH) forming residues; other site 246196015437 trimer interface [polypeptide binding]; other site 246196015438 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 246196015439 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 246196015440 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 246196015441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196015442 putative ADP-binding pocket [chemical binding]; other site 246196015443 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 246196015444 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196015445 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 246196015446 Predicted membrane protein [Function unknown]; Region: COG1511 246196015447 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 246196015448 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 246196015449 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 246196015450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015451 Walker A/P-loop; other site 246196015452 ATP binding site [chemical binding]; other site 246196015453 Q-loop/lid; other site 246196015454 ABC transporter signature motif; other site 246196015455 Walker B; other site 246196015456 magnesium-transporting ATPase; Provisional; Region: PRK15122 246196015457 AMP-binding domain protein; Validated; Region: PRK08315 246196015458 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196015459 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 246196015460 acyl-activating enzyme (AAE) consensus motif; other site 246196015461 acyl-activating enzyme (AAE) consensus motif; other site 246196015462 putative AMP binding site [chemical binding]; other site 246196015463 putative active site [active] 246196015464 putative CoA binding site [chemical binding]; other site 246196015465 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 246196015466 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196015467 acyl-activating enzyme (AAE) consensus motif; other site 246196015468 AMP binding site [chemical binding]; other site 246196015469 active site 246196015470 CoA binding site [chemical binding]; other site 246196015471 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196015472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196015473 DNA binding residues [nucleotide binding] 246196015474 dimerization interface [polypeptide binding]; other site 246196015475 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196015476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196015477 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196015478 dimerization interface [polypeptide binding]; other site 246196015479 substrate binding pocket [chemical binding]; other site 246196015480 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196015481 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 246196015482 Na binding site [ion binding]; other site 246196015483 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196015484 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 246196015485 putative active site [active] 246196015486 catalytic triad [active] 246196015487 putative dimer interface [polypeptide binding]; other site 246196015488 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 246196015489 histidinol dehydrogenase; Region: hisD; TIGR00069 246196015490 NAD binding site [chemical binding]; other site 246196015491 dimerization interface [polypeptide binding]; other site 246196015492 product binding site; other site 246196015493 substrate binding site [chemical binding]; other site 246196015494 zinc binding site [ion binding]; other site 246196015495 catalytic residues [active] 246196015496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196015497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196015498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196015499 dimerization interface [polypeptide binding]; other site 246196015500 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196015501 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196015502 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196015503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196015504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015505 Walker A/P-loop; other site 246196015506 ATP binding site [chemical binding]; other site 246196015507 Q-loop/lid; other site 246196015508 ABC transporter signature motif; other site 246196015509 Walker B; other site 246196015510 D-loop; other site 246196015511 H-loop/switch region; other site 246196015512 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196015513 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196015514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015515 Walker A/P-loop; other site 246196015516 ATP binding site [chemical binding]; other site 246196015517 Q-loop/lid; other site 246196015518 ABC transporter signature motif; other site 246196015519 Walker B; other site 246196015520 D-loop; other site 246196015521 H-loop/switch region; other site 246196015522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196015523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015524 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196015525 Walker A/P-loop; other site 246196015526 ATP binding site [chemical binding]; other site 246196015527 Q-loop/lid; other site 246196015528 ABC transporter signature motif; other site 246196015529 Walker B; other site 246196015530 D-loop; other site 246196015531 H-loop/switch region; other site 246196015532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196015533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196015534 active site 246196015535 phosphorylation site [posttranslational modification] 246196015536 intermolecular recognition site; other site 246196015537 dimerization interface [polypeptide binding]; other site 246196015538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196015539 DNA binding site [nucleotide binding] 246196015540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196015541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196015542 dimerization interface [polypeptide binding]; other site 246196015543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196015544 dimer interface [polypeptide binding]; other site 246196015545 phosphorylation site [posttranslational modification] 246196015546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196015547 ATP binding site [chemical binding]; other site 246196015548 Mg2+ binding site [ion binding]; other site 246196015549 G-X-G motif; other site 246196015550 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246196015551 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 246196015552 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246196015553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196015554 Winged helix-turn helix; Region: HTH_29; pfam13551 246196015555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015556 putative DNA binding site [nucleotide binding]; other site 246196015557 dimerization interface [polypeptide binding]; other site 246196015558 putative Zn2+ binding site [ion binding]; other site 246196015559 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196015560 MarR family; Region: MarR; pfam01047 246196015561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196015562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015563 putative substrate translocation pore; other site 246196015564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015565 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 246196015566 putative deacylase active site [active] 246196015567 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 246196015568 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 246196015569 dimer interface [polypeptide binding]; other site 246196015570 active site 246196015571 citrylCoA binding site [chemical binding]; other site 246196015572 NADH binding [chemical binding]; other site 246196015573 cationic pore residues; other site 246196015574 oxalacetate/citrate binding site [chemical binding]; other site 246196015575 coenzyme A binding site [chemical binding]; other site 246196015576 catalytic triad [active] 246196015577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196015581 putative substrate translocation pore; other site 246196015582 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 246196015583 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 246196015584 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 246196015585 citrate synthase 2; Provisional; Region: PRK12350 246196015586 Citrate synthase; Region: Citrate_synt; pfam00285 246196015587 oxalacetate binding site [chemical binding]; other site 246196015588 citrylCoA binding site [chemical binding]; other site 246196015589 coenzyme A binding site [chemical binding]; other site 246196015590 catalytic triad [active] 246196015591 TIGR03086 family protein; Region: TIGR03086 246196015592 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196015593 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 246196015594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015595 dimerization interface [polypeptide binding]; other site 246196015596 putative DNA binding site [nucleotide binding]; other site 246196015597 putative Zn2+ binding site [ion binding]; other site 246196015598 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 246196015599 putative dimer interface [polypeptide binding]; other site 246196015600 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196015601 Ferredoxin [Energy production and conversion]; Region: COG1146 246196015602 4Fe-4S binding domain; Region: Fer4; pfam00037 246196015603 ferredoxin-NADP+ reductase; Region: PLN02852 246196015604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196015605 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 246196015606 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246196015607 active site 246196015608 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196015609 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196015610 catalytic residue [active] 246196015611 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 246196015612 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 246196015613 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 246196015614 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246196015615 MarR family; Region: MarR_2; cl17246 246196015616 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 246196015617 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 246196015618 hydrophobic ligand binding site; other site 246196015619 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 246196015620 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196015621 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 246196015622 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 246196015623 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246196015624 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 246196015625 putative dimer interface [polypeptide binding]; other site 246196015626 N-terminal domain interface [polypeptide binding]; other site 246196015627 putative substrate binding pocket (H-site) [chemical binding]; other site 246196015628 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246196015629 DNA-binding site [nucleotide binding]; DNA binding site 246196015630 RNA-binding motif; other site 246196015631 hypothetical protein; Provisional; Region: PRK11770 246196015632 Domain of unknown function (DUF307); Region: DUF307; pfam03733 246196015633 Domain of unknown function (DUF307); Region: DUF307; pfam03733 246196015634 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 246196015635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196015636 FeS/SAM binding site; other site 246196015637 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 246196015638 Ubiquitin-like proteins; Region: UBQ; cl00155 246196015639 charged pocket; other site 246196015640 hydrophobic patch; other site 246196015641 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 246196015642 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 246196015643 MoaD interaction [polypeptide binding]; other site 246196015644 active site residues [active] 246196015645 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 246196015646 MPT binding site; other site 246196015647 trimer interface [polypeptide binding]; other site 246196015648 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 246196015649 trimer interface [polypeptide binding]; other site 246196015650 dimer interface [polypeptide binding]; other site 246196015651 putative active site [active] 246196015652 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 246196015653 WYL domain; Region: WYL; pfam13280 246196015654 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 246196015655 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 246196015656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246196015657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196015658 ATP binding site [chemical binding]; other site 246196015659 putative Mg++ binding site [ion binding]; other site 246196015660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196015661 nucleotide binding region [chemical binding]; other site 246196015662 ATP-binding site [chemical binding]; other site 246196015663 Cupin domain; Region: Cupin_2; cl17218 246196015664 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 246196015665 NifQ; Region: NifQ; pfam04891 246196015666 short chain dehydrogenase; Validated; Region: PRK08264 246196015667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015668 NAD(P) binding site [chemical binding]; other site 246196015669 active site 246196015670 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 246196015671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196015672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196015673 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196015674 classical (c) SDRs; Region: SDR_c; cd05233 246196015675 NAD(P) binding site [chemical binding]; other site 246196015676 active site 246196015677 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 246196015678 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196015679 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196015680 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 246196015681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015683 hypothetical protein; Provisional; Region: PRK07588 246196015684 hypothetical protein; Provisional; Region: PRK07236 246196015685 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 246196015686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015687 substrate binding site [chemical binding]; other site 246196015688 oxyanion hole (OAH) forming residues; other site 246196015689 trimer interface [polypeptide binding]; other site 246196015690 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196015691 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196015692 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 246196015693 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196015694 dimer interface [polypeptide binding]; other site 246196015695 active site 246196015696 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 246196015697 homotrimer interaction site [polypeptide binding]; other site 246196015698 putative active site [active] 246196015699 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196015700 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 246196015701 aminotransferase; Validated; Region: PRK07777 246196015702 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196015703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196015704 homodimer interface [polypeptide binding]; other site 246196015705 catalytic residue [active] 246196015706 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 246196015707 allantoicase; Provisional; Region: PRK13257 246196015708 Allantoicase repeat; Region: Allantoicase; pfam03561 246196015709 Allantoicase repeat; Region: Allantoicase; pfam03561 246196015710 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 246196015711 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 246196015712 active site 246196015713 catalytic site [active] 246196015714 tetramer interface [polypeptide binding]; other site 246196015715 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196015716 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 246196015717 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 246196015718 Na binding site [ion binding]; other site 246196015719 putative substrate binding site [chemical binding]; other site 246196015720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196015721 DNA-binding site [nucleotide binding]; DNA binding site 246196015722 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 246196015723 FCD domain; Region: FCD; pfam07729 246196015724 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 246196015725 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196015726 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196015727 Ligand Binding Site [chemical binding]; other site 246196015728 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196015729 Ligand Binding Site [chemical binding]; other site 246196015730 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196015731 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196015732 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 246196015733 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 246196015734 dimer interface [polypeptide binding]; other site 246196015735 PYR/PP interface [polypeptide binding]; other site 246196015736 TPP binding site [chemical binding]; other site 246196015737 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196015738 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 246196015739 TPP-binding site [chemical binding]; other site 246196015740 dimer interface [polypeptide binding]; other site 246196015741 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 246196015742 putative hydrophobic ligand binding site [chemical binding]; other site 246196015743 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 246196015744 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246196015745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196015746 acyl-activating enzyme (AAE) consensus motif; other site 246196015747 AMP binding site [chemical binding]; other site 246196015748 active site 246196015749 CoA binding site [chemical binding]; other site 246196015750 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196015751 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196015752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015753 NAD(P) binding site [chemical binding]; other site 246196015754 active site 246196015755 Uncharacterized conserved protein [Function unknown]; Region: COG1434 246196015756 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 246196015757 putative active site [active] 246196015758 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 246196015759 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 246196015760 nucleophile elbow; other site 246196015761 Gas vesicle protein K; Region: GvpK; pfam05121 246196015762 Gas vesicle protein; Region: Gas_vesicle; cl02954 246196015763 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 246196015764 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 246196015765 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246196015766 putative active site [active] 246196015767 putative metal binding site [ion binding]; other site 246196015768 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 246196015769 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 246196015770 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 246196015771 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 246196015772 Int/Topo IB signature motif; other site 246196015773 PE-PPE domain; Region: PE-PPE; pfam08237 246196015774 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196015775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196015776 DNA-binding site [nucleotide binding]; DNA binding site 246196015777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196015778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196015779 homodimer interface [polypeptide binding]; other site 246196015780 catalytic residue [active] 246196015781 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 246196015782 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196015783 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196015784 putative NAD(P) binding site [chemical binding]; other site 246196015785 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196015786 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 246196015787 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 246196015788 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 246196015789 apolar tunnel; other site 246196015790 heme binding site [chemical binding]; other site 246196015791 dimerization interface [polypeptide binding]; other site 246196015792 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196015793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 246196015794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015795 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 246196015796 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 246196015797 homodimer interface [polypeptide binding]; other site 246196015798 putative substrate binding pocket [chemical binding]; other site 246196015799 diiron center [ion binding]; other site 246196015800 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 246196015801 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 246196015802 FMN binding site [chemical binding]; other site 246196015803 active site 246196015804 catalytic residues [active] 246196015805 substrate binding site [chemical binding]; other site 246196015806 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 246196015807 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196015808 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 246196015809 PhoU domain; Region: PhoU; pfam01895 246196015810 PhoU domain; Region: PhoU; pfam01895 246196015811 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015813 dimerization interface [polypeptide binding]; other site 246196015814 putative Zn2+ binding site [ion binding]; other site 246196015815 putative DNA binding site [nucleotide binding]; other site 246196015816 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196015817 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196015818 NAD(P) binding site [chemical binding]; other site 246196015819 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 246196015820 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 246196015821 Walker A/P-loop; other site 246196015822 ATP binding site [chemical binding]; other site 246196015823 Q-loop/lid; other site 246196015824 ABC transporter signature motif; other site 246196015825 Walker B; other site 246196015826 D-loop; other site 246196015827 H-loop/switch region; other site 246196015828 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 246196015829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015830 dimer interface [polypeptide binding]; other site 246196015831 conserved gate region; other site 246196015832 putative PBP binding loops; other site 246196015833 ABC-ATPase subunit interface; other site 246196015834 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 246196015835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015836 dimer interface [polypeptide binding]; other site 246196015837 conserved gate region; other site 246196015838 putative PBP binding loops; other site 246196015839 ABC-ATPase subunit interface; other site 246196015840 PBP superfamily domain; Region: PBP_like_2; cl17296 246196015841 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 246196015842 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196015843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196015844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196015845 DNA binding site [nucleotide binding] 246196015846 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 246196015847 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246196015848 catalytic residues [active] 246196015849 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 246196015850 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 246196015851 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 246196015852 active site residue [active] 246196015853 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 246196015854 active site residue [active] 246196015855 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 246196015856 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 246196015857 heme-binding site [chemical binding]; other site 246196015858 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 246196015859 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 246196015860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196015861 catalytic residue [active] 246196015862 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 246196015863 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 246196015864 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 246196015865 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 246196015866 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 246196015867 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 246196015868 dimerization interface [polypeptide binding]; other site 246196015869 putative ATP binding site [chemical binding]; other site 246196015870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015871 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196015872 NAD(P) binding site [chemical binding]; other site 246196015873 active site 246196015874 amidophosphoribosyltransferase; Provisional; Region: PRK07847 246196015875 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 246196015876 active site 246196015877 tetramer interface [polypeptide binding]; other site 246196015878 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196015879 active site 246196015880 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 246196015881 short chain dehydrogenase; Provisional; Region: PRK06500 246196015882 classical (c) SDRs; Region: SDR_c; cd05233 246196015883 NAD(P) binding site [chemical binding]; other site 246196015884 active site 246196015885 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 246196015886 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 246196015887 Walker A/P-loop; other site 246196015888 ATP binding site [chemical binding]; other site 246196015889 Q-loop/lid; other site 246196015890 ABC transporter signature motif; other site 246196015891 Walker B; other site 246196015892 D-loop; other site 246196015893 H-loop/switch region; other site 246196015894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015895 dimer interface [polypeptide binding]; other site 246196015896 conserved gate region; other site 246196015897 ABC-ATPase subunit interface; other site 246196015898 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 246196015899 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196015900 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196015901 active site 246196015902 non-prolyl cis peptide bond; other site 246196015903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015905 short chain dehydrogenase; Provisional; Region: PRK12827 246196015906 classical (c) SDRs; Region: SDR_c; cd05233 246196015907 NAD(P) binding site [chemical binding]; other site 246196015908 active site 246196015909 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196015910 classical (c) SDRs; Region: SDR_c; cd05233 246196015911 NAD(P) binding site [chemical binding]; other site 246196015912 active site 246196015913 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246196015914 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 246196015915 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196015916 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196015917 NAD(P) binding site [chemical binding]; other site 246196015918 catalytic residues [active] 246196015919 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196015920 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196015921 mce related protein; Region: MCE; pfam02470 246196015922 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196015923 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 246196015924 hypothetical protein; Validated; Region: PRK09169 246196015925 CAAX protease self-immunity; Region: Abi; pfam02517 246196015926 Predicted membrane protein [Function unknown]; Region: COG4425 246196015927 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 246196015928 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 246196015929 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 246196015930 dimerization interface [polypeptide binding]; other site 246196015931 ATP binding site [chemical binding]; other site 246196015932 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 246196015933 dimerization interface [polypeptide binding]; other site 246196015934 ATP binding site [chemical binding]; other site 246196015935 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 246196015936 thiamine pyrophosphate protein; Provisional; Region: PRK08273 246196015937 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246196015938 PYR/PP interface [polypeptide binding]; other site 246196015939 dimer interface [polypeptide binding]; other site 246196015940 tetramer interface [polypeptide binding]; other site 246196015941 TPP binding site [chemical binding]; other site 246196015942 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196015943 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196015944 TPP-binding site [chemical binding]; other site 246196015945 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196015946 active site 246196015947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196015948 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 246196015949 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 246196015950 active site 246196015951 metal binding site [ion binding]; metal-binding site 246196015952 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 246196015953 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 246196015954 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 246196015955 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 246196015956 putative active site [active] 246196015957 catalytic triad [active] 246196015958 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 246196015959 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196015960 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 246196015961 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196015962 FAD binding domain; Region: FAD_binding_2; pfam00890 246196015963 Predicted deacetylase [General function prediction only]; Region: COG3233 246196015964 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 246196015965 putative active site [active] 246196015966 putative Zn binding site [ion binding]; other site 246196015967 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 246196015968 catalytic residues [active] 246196015969 dimer interface [polypeptide binding]; other site 246196015970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015972 WHG domain; Region: WHG; pfam13305 246196015973 Predicted membrane protein [Function unknown]; Region: COG4270 246196015974 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 246196015975 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196015976 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 246196015977 ATP binding site [chemical binding]; other site 246196015978 active site 246196015979 substrate binding site [chemical binding]; other site 246196015980 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 246196015981 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196015982 putative active site [active] 246196015983 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196015984 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 246196015985 gating phenylalanine in ion channel; other site 246196015986 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196015987 Cytochrome P450; Region: p450; cl12078 246196015988 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 246196015989 adenylosuccinate lyase; Region: purB; TIGR00928 246196015990 tetramer interface [polypeptide binding]; other site 246196015991 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 246196015992 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 246196015993 synthetase active site [active] 246196015994 NTP binding site [chemical binding]; other site 246196015995 metal binding site [ion binding]; metal-binding site 246196015996 amino acid transporter; Region: 2A0306; TIGR00909 246196015997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 246196015998 Putative esterase; Region: Esterase; pfam00756 246196015999 S-formylglutathione hydrolase; Region: PLN02442 246196016000 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 246196016001 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 246196016002 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 246196016003 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 246196016004 Cytochrome P450; Region: p450; cl12078 246196016005 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196016006 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 246196016007 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196016008 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196016009 short chain dehydrogenase; Provisional; Region: PRK07774 246196016010 classical (c) SDRs; Region: SDR_c; cd05233 246196016011 NAD(P) binding site [chemical binding]; other site 246196016012 active site 246196016013 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 246196016014 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196016015 NAD binding site [chemical binding]; other site 246196016016 catalytic residues [active] 246196016017 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196016018 Cytochrome P450; Region: p450; cl12078 246196016019 short chain dehydrogenase; Provisional; Region: PRK07775 246196016020 classical (c) SDRs; Region: SDR_c; cd05233 246196016021 NAD(P) binding site [chemical binding]; other site 246196016022 active site 246196016023 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196016024 Cytochrome P450; Region: p450; cl12078 246196016025 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 246196016026 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246196016027 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196016028 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 246196016029 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196016030 NAD binding site [chemical binding]; other site 246196016031 catalytic Zn binding site [ion binding]; other site 246196016032 substrate binding site [chemical binding]; other site 246196016033 structural Zn binding site [ion binding]; other site 246196016034 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196016035 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196016036 classical (c) SDRs; Region: SDR_c; cd05233 246196016037 active site 246196016038 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 246196016039 nucleotide binding site/active site [active] 246196016040 HIT family signature motif; other site 246196016041 catalytic residue [active] 246196016042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196016043 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196016044 dimerization interface [polypeptide binding]; other site 246196016045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196016046 dimer interface [polypeptide binding]; other site 246196016047 phosphorylation site [posttranslational modification] 246196016048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196016049 ATP binding site [chemical binding]; other site 246196016050 Mg2+ binding site [ion binding]; other site 246196016051 G-X-G motif; other site 246196016052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196016053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196016054 active site 246196016055 phosphorylation site [posttranslational modification] 246196016056 intermolecular recognition site; other site 246196016057 dimerization interface [polypeptide binding]; other site 246196016058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196016059 DNA binding site [nucleotide binding] 246196016060 HNH endonuclease; Region: HNH_3; pfam13392 246196016061 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 246196016062 Cutinase; Region: Cutinase; pfam01083 246196016063 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 246196016064 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196016065 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196016066 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196016067 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 246196016068 putative hydrophobic ligand binding site [chemical binding]; other site 246196016069 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196016070 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 246196016071 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196016072 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196016073 catalytic loop [active] 246196016074 iron binding site [ion binding]; other site 246196016075 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196016076 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196016077 short chain dehydrogenase; Provisional; Region: PRK05875 246196016078 classical (c) SDRs; Region: SDR_c; cd05233 246196016079 NAD(P) binding site [chemical binding]; other site 246196016080 active site 246196016081 enoyl-CoA hydratase; Provisional; Region: PRK08290 246196016082 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196016083 substrate binding site [chemical binding]; other site 246196016084 oxyanion hole (OAH) forming residues; other site 246196016085 trimer interface [polypeptide binding]; other site 246196016086 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 246196016087 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 246196016088 active site 246196016089 homotetramer interface [polypeptide binding]; other site 246196016090 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196016091 Winged helix-turn helix; Region: HTH_29; pfam13551 246196016092 Homeodomain-like domain; Region: HTH_32; pfam13565 246196016093 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196016094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 246196016095 SnoaL-like domain; Region: SnoaL_4; cl17707 246196016096 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196016097 mce related protein; Region: MCE; pfam02470 246196016098 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196016099 mce related protein; Region: MCE; pfam02470 246196016100 mce related protein; Region: MCE; pfam02470 246196016101 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196016102 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196016103 mce related protein; Region: MCE; pfam02470 246196016104 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196016105 mce related protein; Region: MCE; pfam02470 246196016106 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196016107 mce related protein; Region: MCE; pfam02470 246196016108 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196016109 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196016110 Permease; Region: Permease; pfam02405 246196016111 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196016112 Permease; Region: Permease; pfam02405 246196016113 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 246196016114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016115 NAD(P) binding site [chemical binding]; other site 246196016116 active site 246196016117 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 246196016118 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246196016119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016120 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 246196016121 FAD binding site [chemical binding]; other site 246196016122 substrate binding site [chemical binding]; other site 246196016123 catalytic base [active] 246196016124 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016125 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196016126 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196016127 active site 246196016128 acyl-CoA synthetase; Validated; Region: PRK07867 246196016129 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 246196016130 acyl-activating enzyme (AAE) consensus motif; other site 246196016131 putative AMP binding site [chemical binding]; other site 246196016132 putative active site [active] 246196016133 putative CoA binding site [chemical binding]; other site 246196016134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016135 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 246196016136 NAD(P) binding site [chemical binding]; other site 246196016137 active site 246196016138 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196016139 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 246196016140 dimer interface [polypeptide binding]; other site 246196016141 ligand binding site [chemical binding]; other site 246196016142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196016143 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 246196016144 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 246196016145 NAD(P) binding site [chemical binding]; other site 246196016146 catalytic residues [active] 246196016147 Nitronate monooxygenase; Region: NMO; pfam03060 246196016148 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196016149 FMN binding site [chemical binding]; other site 246196016150 substrate binding site [chemical binding]; other site 246196016151 putative catalytic residue [active] 246196016152 acyl-CoA synthetase; Validated; Region: PRK07798 246196016153 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196016154 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 246196016155 acyl-activating enzyme (AAE) consensus motif; other site 246196016156 acyl-activating enzyme (AAE) consensus motif; other site 246196016157 putative AMP binding site [chemical binding]; other site 246196016158 putative active site [active] 246196016159 putative CoA binding site [chemical binding]; other site 246196016160 enoyl-CoA hydratase; Provisional; Region: PRK07799 246196016161 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196016162 substrate binding site [chemical binding]; other site 246196016163 oxyanion hole (OAH) forming residues; other site 246196016164 trimer interface [polypeptide binding]; other site 246196016165 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 246196016166 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196016167 Cytochrome P450; Region: p450; cl12078 246196016168 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 246196016169 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196016170 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 246196016171 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 246196016172 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 246196016173 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196016174 lipid-transfer protein; Provisional; Region: PRK07937 246196016175 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196016176 active site 246196016177 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 246196016178 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196016179 active site 246196016180 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196016181 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 246196016182 CotH protein; Region: CotH; pfam08757 246196016183 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 246196016184 putative metal binding residues [ion binding]; other site 246196016185 signature motif; other site 246196016186 dimer interface [polypeptide binding]; other site 246196016187 active site 246196016188 polyP binding site; other site 246196016189 substrate binding site [chemical binding]; other site 246196016190 acceptor-phosphate pocket; other site 246196016191 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 246196016192 short chain dehydrogenase; Provisional; Region: PRK07890 246196016193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016194 NAD(P) binding site [chemical binding]; other site 246196016195 active site 246196016196 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196016197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196016198 putative DNA binding site [nucleotide binding]; other site 246196016199 putative Zn2+ binding site [ion binding]; other site 246196016200 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 246196016201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196016202 ATP binding site [chemical binding]; other site 246196016203 putative Mg++ binding site [ion binding]; other site 246196016204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196016205 nucleotide binding region [chemical binding]; other site 246196016206 ATP-binding site [chemical binding]; other site 246196016207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196016208 active site 246196016209 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 246196016210 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 246196016211 active site 246196016212 catalytic residues [active] 246196016213 metal binding site [ion binding]; metal-binding site 246196016214 DmpG-like communication domain; Region: DmpG_comm; pfam07836 246196016215 acetaldehyde dehydrogenase; Validated; Region: PRK08300 246196016216 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246196016217 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 246196016218 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 246196016219 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 246196016220 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196016221 enoyl-CoA hydratase; Region: PLN02864 246196016222 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 246196016223 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 246196016224 dimer interaction site [polypeptide binding]; other site 246196016225 substrate-binding tunnel; other site 246196016226 active site 246196016227 catalytic site [active] 246196016228 substrate binding site [chemical binding]; other site 246196016229 AMP-binding enzyme; Region: AMP-binding; pfam00501 246196016230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196016231 active site 246196016232 CoA binding site [chemical binding]; other site 246196016233 AMP binding site [chemical binding]; other site 246196016234 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196016235 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246196016236 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196016237 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 246196016238 putative active site [active] 246196016239 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 246196016240 active site 246196016241 substrate binding site [chemical binding]; other site 246196016242 trimer interface [polypeptide binding]; other site 246196016243 CoA binding site [chemical binding]; other site 246196016244 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 246196016245 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246196016246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246196016247 active site 246196016248 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 246196016249 putative trimer interface [polypeptide binding]; other site 246196016250 putative active site [active] 246196016251 putative substrate binding site [chemical binding]; other site 246196016252 putative CoA binding site [chemical binding]; other site 246196016253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196016254 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 246196016255 putative ADP-binding pocket [chemical binding]; other site 246196016256 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 246196016257 active site 246196016258 catalytic triad [active] 246196016259 oxyanion hole [active] 246196016260 Chain length determinant protein; Region: Wzz; pfam02706 246196016261 Chain length determinant protein; Region: Wzz; cl15801 246196016262 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196016263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016264 NAD(P) binding site [chemical binding]; other site 246196016265 active site 246196016266 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 246196016267 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196016268 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246196016269 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246196016270 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 246196016271 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 246196016272 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246196016273 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 246196016274 Probable Catalytic site; other site 246196016275 metal-binding site 246196016276 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 246196016277 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246196016278 putative active site [active] 246196016279 putative metal binding site [ion binding]; other site 246196016280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196016281 active site 246196016282 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 246196016283 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 246196016284 putative glycosyl transferase; Provisional; Region: PRK10307 246196016285 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 246196016286 classical (c) SDRs; Region: SDR_c; cd05233 246196016287 NAD(P) binding site [chemical binding]; other site 246196016288 active site 246196016289 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246196016290 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246196016291 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196016292 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 246196016293 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 246196016294 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 246196016295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196016296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196016297 catalytic residue [active] 246196016298 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 246196016299 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196016300 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 246196016301 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 246196016302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196016303 extended (e) SDRs; Region: SDR_e; cd08946 246196016304 NAD(P) binding site [chemical binding]; other site 246196016305 active site 246196016306 substrate binding site [chemical binding]; other site 246196016307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016308 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 246196016309 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 246196016310 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196016311 active site 246196016312 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 246196016313 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196016314 Methyltransferase domain; Region: Methyltransf_12; pfam08242 246196016315 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 246196016316 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 246196016317 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 246196016318 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246196016319 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246196016320 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 246196016321 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 246196016322 substrate binding site; other site 246196016323 tetramer interface; other site 246196016324 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 246196016325 Bacterial sugar transferase; Region: Bac_transf; pfam02397 246196016326 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196016327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016328 NAD(P) binding site [chemical binding]; other site 246196016329 active site 246196016330 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246196016331 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246196016332 glutaminase active site [active] 246196016333 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196016334 dimer interface [polypeptide binding]; other site 246196016335 active site 246196016336 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246196016337 dimer interface [polypeptide binding]; other site 246196016338 active site 246196016339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196016340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196016341 active site 246196016342 phosphorylation site [posttranslational modification] 246196016343 intermolecular recognition site; other site 246196016344 dimerization interface [polypeptide binding]; other site 246196016345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196016346 DNA binding residues [nucleotide binding] 246196016347 dimerization interface [polypeptide binding]; other site 246196016348 lipid-transfer protein; Provisional; Region: PRK07855 246196016349 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196016350 active site 246196016351 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 246196016352 putative active site [active] 246196016353 putative catalytic site [active] 246196016354 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196016355 active site 246196016356 catalytic site [active] 246196016357 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 246196016358 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196016359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016360 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016361 active site 246196016362 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016363 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016365 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016366 active site 246196016367 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196016368 Cytochrome P450; Region: p450; cl12078 246196016369 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 246196016370 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196016371 dimer interface [polypeptide binding]; other site 246196016372 active site 246196016373 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196016374 short chain dehydrogenase; Provisional; Region: PRK07791 246196016375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016376 NAD(P) binding site [chemical binding]; other site 246196016377 active site 246196016378 short chain dehydrogenase; Provisional; Region: PRK07856 246196016379 classical (c) SDRs; Region: SDR_c; cd05233 246196016380 NAD(P) binding site [chemical binding]; other site 246196016381 active site 246196016382 enoyl-CoA hydratase; Provisional; Region: PRK06495 246196016383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196016384 substrate binding site [chemical binding]; other site 246196016385 oxyanion hole (OAH) forming residues; other site 246196016386 trimer interface [polypeptide binding]; other site 246196016387 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 246196016388 Coenzyme A transferase; Region: CoA_trans; cl17247 246196016389 Nitronate monooxygenase; Region: NMO; pfam03060 246196016390 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196016391 FMN binding site [chemical binding]; other site 246196016392 substrate binding site [chemical binding]; other site 246196016393 putative catalytic residue [active] 246196016394 potential frameshift: common BLAST hit: gi|296138868|ref|YP_003646111.1| cation diffusion facilitator family transporter 246196016395 Cation efflux family; Region: Cation_efflux; cl00316 246196016396 Cation efflux family; Region: Cation_efflux; cl00316 246196016397 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 246196016398 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196016399 dimer interface [polypeptide binding]; other site 246196016400 active site 246196016401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196016403 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 246196016404 short chain dehydrogenase; Provisional; Region: PRK07831 246196016405 classical (c) SDRs; Region: SDR_c; cd05233 246196016406 NAD(P) binding site [chemical binding]; other site 246196016407 active site 246196016408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016410 active site 246196016411 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 246196016412 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196016413 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 246196016414 acyl-activating enzyme (AAE) consensus motif; other site 246196016415 acyl-activating enzyme (AAE) consensus motif; other site 246196016416 putative AMP binding site [chemical binding]; other site 246196016417 putative active site [active] 246196016418 putative CoA binding site [chemical binding]; other site 246196016419 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016420 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016421 active site 246196016422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016423 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196016424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016425 active site 246196016426 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016427 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016428 active site 246196016429 aspartate aminotransferase; Provisional; Region: PRK05764 246196016430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196016431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196016432 homodimer interface [polypeptide binding]; other site 246196016433 catalytic residue [active] 246196016434 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196016435 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196016436 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196016437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196016438 TM-ABC transporter signature motif; other site 246196016439 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196016440 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196016441 Walker A/P-loop; other site 246196016442 ATP binding site [chemical binding]; other site 246196016443 Q-loop/lid; other site 246196016444 ABC transporter signature motif; other site 246196016445 Walker B; other site 246196016446 D-loop; other site 246196016447 H-loop/switch region; other site 246196016448 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 246196016449 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 246196016450 putative ligand binding site [chemical binding]; other site 246196016451 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 246196016452 xylose isomerase; Provisional; Region: PRK12677 246196016453 MarR family; Region: MarR_2; pfam12802 246196016454 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196016455 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196016456 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196016457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246196016458 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196016459 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196016460 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196016461 active site 246196016462 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 246196016463 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 246196016464 acyl-activating enzyme (AAE) consensus motif; other site 246196016465 putative AMP binding site [chemical binding]; other site 246196016466 putative active site [active] 246196016467 putative CoA binding site [chemical binding]; other site 246196016468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016469 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 246196016470 NAD(P) binding site [chemical binding]; other site 246196016471 active site 246196016472 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196016473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196016474 putative substrate translocation pore; other site 246196016475 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196016476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196016477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196016478 dimerization interface [polypeptide binding]; other site 246196016479 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246196016480 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196016481 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196016482 Cytochrome P450; Region: p450; cl12078 246196016483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196016484 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196016485 classical (c) SDRs; Region: SDR_c; cd05233 246196016486 NAD(P) binding site [chemical binding]; other site 246196016487 active site 246196016488 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 246196016489 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 246196016490 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 246196016491 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 246196016492 active site 246196016493 Fe binding site [ion binding]; other site 246196016494 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 246196016495 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246196016496 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016497 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 246196016498 Flavin binding site [chemical binding]; other site 246196016499 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 246196016500 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 246196016501 FAD binding pocket [chemical binding]; other site 246196016502 FAD binding motif [chemical binding]; other site 246196016503 phosphate binding motif [ion binding]; other site 246196016504 beta-alpha-beta structure motif; other site 246196016505 NAD(p) ribose binding residues [chemical binding]; other site 246196016506 NAD binding pocket [chemical binding]; other site 246196016507 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 246196016508 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196016509 catalytic loop [active] 246196016510 iron binding site [ion binding]; other site 246196016511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016512 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016513 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016514 active site 246196016515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196016517 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 246196016518 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 246196016519 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 246196016520 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 246196016521 putative ligand binding site [chemical binding]; other site 246196016522 putative dimerization interface [polypeptide binding]; other site 246196016523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 246196016524 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 246196016525 ABC-ATPase subunit interface; other site 246196016526 dimer interface [polypeptide binding]; other site 246196016527 putative PBP binding regions; other site 246196016528 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 246196016529 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 246196016530 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196016531 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 246196016532 intersubunit interface [polypeptide binding]; other site 246196016533 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 246196016534 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 246196016535 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 246196016536 PQQ-like domain; Region: PQQ_2; pfam13360 246196016537 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196016538 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 246196016539 intersubunit interface [polypeptide binding]; other site 246196016540 PQQ-like domain; Region: PQQ_2; pfam13360 246196016541 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 246196016542 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 246196016543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196016544 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 246196016545 Walker A/P-loop; other site 246196016546 ATP binding site [chemical binding]; other site 246196016547 ABC transporter signature motif; other site 246196016548 Walker B; other site 246196016549 D-loop; other site 246196016550 H-loop/switch region; other site 246196016551 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 246196016552 putative FMN binding site [chemical binding]; other site 246196016553 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 246196016554 putative active site [active] 246196016555 MspA; Region: MspA; pfam09203 246196016556 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246196016557 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196016558 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 246196016559 Predicted permease; Region: DUF318; cl17795 246196016560 TIGR03943 family protein; Region: TIGR03943 246196016561 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246196016562 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196016563 Walker A/P-loop; other site 246196016564 ATP binding site [chemical binding]; other site 246196016565 Q-loop/lid; other site 246196016566 ABC transporter signature motif; other site 246196016567 Walker B; other site 246196016568 D-loop; other site 246196016569 H-loop/switch region; other site 246196016570 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 246196016571 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246196016572 putative PBP binding regions; other site 246196016573 ABC-ATPase subunit interface; other site 246196016574 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 246196016575 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246196016576 putative ligand binding residues [chemical binding]; other site 246196016577 30S ribosomal protein S18; Provisional; Region: PRK13401 246196016578 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 246196016579 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 246196016580 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 246196016581 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 246196016582 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 246196016583 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196016584 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 246196016585 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246196016586 transmembrane helices; other site 246196016587 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246196016588 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 246196016589 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 246196016590 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246196016591 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 246196016592 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246196016593 active site 246196016594 HIGH motif; other site 246196016595 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246196016596 KMSKS motif; other site 246196016597 tRNA binding surface [nucleotide binding]; other site 246196016598 anticodon binding site; other site 246196016599 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 246196016600 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 246196016601 homotrimer interaction site [polypeptide binding]; other site 246196016602 zinc binding site [ion binding]; other site 246196016603 CDP-binding sites; other site 246196016604 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 246196016605 substrate binding site; other site 246196016606 dimer interface; other site 246196016607 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 246196016608 DNA repair protein RadA; Provisional; Region: PRK11823 246196016609 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246196016610 Walker A motif; other site 246196016611 ATP binding site [chemical binding]; other site 246196016612 Walker B motif; other site 246196016613 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 246196016614 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 246196016615 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 246196016616 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 246196016617 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 246196016618 active site clefts [active] 246196016619 zinc binding site [ion binding]; other site 246196016620 dimer interface [polypeptide binding]; other site 246196016621 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246196016622 endonuclease III; Region: ENDO3c; smart00478 246196016623 minor groove reading motif; other site 246196016624 helix-hairpin-helix signature motif; other site 246196016625 substrate binding pocket [chemical binding]; other site 246196016626 active site 246196016627 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 246196016628 potential frameshift: common BLAST hit: gi|375139371|ref|YP_005000020.1| transcriptional regulator containing an amidase domain and an 246196016629 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 246196016630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196016631 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196016632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196016633 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 246196016634 conserved cys residue [active] 246196016635 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196016636 Lipase (class 2); Region: Lipase_2; pfam01674 246196016637 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196016638 catalytic site [active] 246196016639 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 246196016640 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 246196016641 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 246196016642 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 246196016643 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196016644 catalytic core [active] 246196016645 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 246196016646 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 246196016647 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 246196016648 Clp amino terminal domain; Region: Clp_N; pfam02861 246196016649 Clp amino terminal domain; Region: Clp_N; pfam02861 246196016650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016651 Walker A motif; other site 246196016652 ATP binding site [chemical binding]; other site 246196016653 Walker B motif; other site 246196016654 arginine finger; other site 246196016655 UvrB/uvrC motif; Region: UVR; pfam02151 246196016656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016657 Walker A motif; other site 246196016658 ATP binding site [chemical binding]; other site 246196016659 Walker B motif; other site 246196016660 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246196016661 Lsr2; Region: Lsr2; pfam11774 246196016662 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 246196016663 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 246196016664 dimer interface [polypeptide binding]; other site 246196016665 putative anticodon binding site; other site 246196016666 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246196016667 motif 1; other site 246196016668 dimer interface [polypeptide binding]; other site 246196016669 active site 246196016670 motif 2; other site 246196016671 motif 3; other site 246196016672 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 246196016673 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 246196016674 active site 246196016675 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196016676 dimer interface [polypeptide binding]; other site 246196016677 substrate binding site [chemical binding]; other site 246196016678 catalytic residue [active] 246196016679 pantothenate kinase; Reviewed; Region: PRK13318 246196016680 Pantoate-beta-alanine ligase; Region: PanC; cd00560 246196016681 pantoate--beta-alanine ligase; Region: panC; TIGR00018 246196016682 active site 246196016683 ATP-binding site [chemical binding]; other site 246196016684 pantoate-binding site; other site 246196016685 HXXH motif; other site 246196016686 Rossmann-like domain; Region: Rossmann-like; pfam10727 246196016687 Uncharacterized conserved protein [Function unknown]; Region: COG5495 246196016688 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 246196016689 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 246196016690 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 246196016691 catalytic center binding site [active] 246196016692 ATP binding site [chemical binding]; other site 246196016693 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 246196016694 homooctamer interface [polypeptide binding]; other site 246196016695 active site 246196016696 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 246196016697 dihydropteroate synthase; Region: DHPS; TIGR01496 246196016698 substrate binding pocket [chemical binding]; other site 246196016699 dimer interface [polypeptide binding]; other site 246196016700 inhibitor binding site; inhibition site 246196016701 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 246196016702 homodecamer interface [polypeptide binding]; other site 246196016703 GTP cyclohydrolase I; Provisional; Region: PLN03044 246196016704 active site 246196016705 putative catalytic site residues [active] 246196016706 zinc binding site [ion binding]; other site 246196016707 GTP-CH-I/GFRP interaction surface; other site 246196016708 FtsH Extracellular; Region: FtsH_ext; pfam06480 246196016709 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 246196016710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016711 Walker A motif; other site 246196016712 ATP binding site [chemical binding]; other site 246196016713 Walker B motif; other site 246196016714 arginine finger; other site 246196016715 Peptidase family M41; Region: Peptidase_M41; pfam01434 246196016716 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196016717 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196016718 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196016719 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 246196016720 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196016721 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196016722 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 246196016723 putative NAD(P) binding site [chemical binding]; other site 246196016724 catalytic Zn binding site [ion binding]; other site 246196016725 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 246196016726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196016727 active site 246196016728 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 246196016729 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 246196016730 Ligand Binding Site [chemical binding]; other site 246196016731 TilS substrate binding domain; Region: TilS; pfam09179 246196016732 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 246196016733 putative hydrolase; Region: TIGR03624 246196016734 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 246196016735 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 246196016736 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 246196016737 dimer interface [polypeptide binding]; other site 246196016738 substrate binding site [chemical binding]; other site 246196016739 metal binding sites [ion binding]; metal-binding site 246196016740 putative OHCU decarboxylase; Provisional; Region: PRK13798 246196016741 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 246196016742 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 246196016743 putative ligand binding site [chemical binding]; other site 246196016744 NAD binding site [chemical binding]; other site 246196016745 dimer interface [polypeptide binding]; other site 246196016746 putative catalytic site [active] 246196016747 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 246196016748 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 246196016749 active site 246196016750 tetramer interface [polypeptide binding]; other site 246196016751 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196016752 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196016753 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196016754 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196016755 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 246196016756 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196016757 Walker A/P-loop; other site 246196016758 ATP binding site [chemical binding]; other site 246196016759 Q-loop/lid; other site 246196016760 ABC transporter signature motif; other site 246196016761 Walker B; other site 246196016762 D-loop; other site 246196016763 H-loop/switch region; other site 246196016764 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196016765 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 246196016766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196016767 Walker A/P-loop; other site 246196016768 ATP binding site [chemical binding]; other site 246196016769 Q-loop/lid; other site 246196016770 ABC transporter signature motif; other site 246196016771 Walker B; other site 246196016772 D-loop; other site 246196016773 H-loop/switch region; other site 246196016774 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196016775 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 246196016776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196016777 dimer interface [polypeptide binding]; other site 246196016778 conserved gate region; other site 246196016779 putative PBP binding loops; other site 246196016780 ABC-ATPase subunit interface; other site 246196016781 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196016782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196016783 dimer interface [polypeptide binding]; other site 246196016784 conserved gate region; other site 246196016785 ABC-ATPase subunit interface; other site 246196016786 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196016787 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 246196016788 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 246196016789 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 246196016790 putative ligand binding site [chemical binding]; other site 246196016791 NAD binding site [chemical binding]; other site 246196016792 catalytic site [active] 246196016793 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 246196016794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196016795 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 246196016796 putative dimerization interface [polypeptide binding]; other site 246196016797 putative substrate binding pocket [chemical binding]; other site 246196016798 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246196016799 anti sigma factor interaction site; other site 246196016800 regulatory phosphorylation site [posttranslational modification]; other site 246196016801 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246196016802 Response regulator receiver domain; Region: Response_reg; pfam00072 246196016803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196016804 active site 246196016805 phosphorylation site [posttranslational modification] 246196016806 intermolecular recognition site; other site 246196016807 dimerization interface [polypeptide binding]; other site 246196016808 CHASE3 domain; Region: CHASE3; pfam05227 246196016809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196016810 dimerization interface [polypeptide binding]; other site 246196016811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196016812 dimer interface [polypeptide binding]; other site 246196016813 phosphorylation site [posttranslational modification] 246196016814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196016815 ATP binding site [chemical binding]; other site 246196016816 Mg2+ binding site [ion binding]; other site 246196016817 G-X-G motif; other site 246196016818 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246196016819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196016820 active site 246196016821 phosphorylation site [posttranslational modification] 246196016822 intermolecular recognition site; other site 246196016823 dimerization interface [polypeptide binding]; other site 246196016824 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 246196016825 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 246196016826 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 246196016827 active site 246196016828 tetramer interface [polypeptide binding]; other site 246196016829 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 246196016830 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 246196016831 catalytic residue [active] 246196016832 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 246196016833 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 246196016834 dimer interface [polypeptide binding]; other site 246196016835 NADP binding site [chemical binding]; other site 246196016836 catalytic residues [active] 246196016837 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 246196016838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196016839 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246196016840 acyl-activating enzyme (AAE) consensus motif; other site 246196016841 AMP binding site [chemical binding]; other site 246196016842 active site 246196016843 CoA binding site [chemical binding]; other site 246196016844 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196016845 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 246196016846 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246196016847 putative trimer interface [polypeptide binding]; other site 246196016848 putative CoA binding site [chemical binding]; other site 246196016849 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246196016850 putative trimer interface [polypeptide binding]; other site 246196016851 putative CoA binding site [chemical binding]; other site 246196016852 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 246196016853 Zn binding site [ion binding]; other site 246196016854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016855 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196016856 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196016857 active site 246196016858 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196016859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016860 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196016861 NAD(P) binding site [chemical binding]; other site 246196016862 active site 246196016863 PE-PPE domain; Region: PE-PPE; pfam08237 246196016864 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196016865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196016866 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196016867 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196016868 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246196016869 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196016870 DNA polymerase III subunit delta'; Validated; Region: PRK07940 246196016871 DNA polymerase III subunit delta'; Validated; Region: PRK08485 246196016872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196016873 dimerization interface [polypeptide binding]; other site 246196016874 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196016875 cyclase homology domain; Region: CHD; cd07302 246196016876 nucleotidyl binding site; other site 246196016877 metal binding site [ion binding]; metal-binding site 246196016878 dimer interface [polypeptide binding]; other site 246196016879 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196016880 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 246196016881 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 246196016882 active site 246196016883 interdomain interaction site; other site 246196016884 putative metal-binding site [ion binding]; other site 246196016885 nucleotide binding site [chemical binding]; other site 246196016886 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 246196016887 domain I; other site 246196016888 phosphate binding site [ion binding]; other site 246196016889 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 246196016890 domain II; other site 246196016891 domain III; other site 246196016892 nucleotide binding site [chemical binding]; other site 246196016893 DNA binding groove [nucleotide binding] 246196016894 catalytic site [active] 246196016895 domain IV; other site 246196016896 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 246196016897 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 246196016898 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 246196016899 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246196016900 DNA-binding site [nucleotide binding]; DNA binding site 246196016901 RNA-binding motif; other site 246196016902 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 246196016903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196016904 ATP binding site [chemical binding]; other site 246196016905 putative Mg++ binding site [ion binding]; other site 246196016906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196016907 nucleotide binding region [chemical binding]; other site 246196016908 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 246196016909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196016910 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196016911 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196016912 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 246196016913 potential protein location (Conserved hypothetical membrane protein) that overlaps protein (hypothetical protein) 246196016914 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 246196016915 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 246196016916 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 246196016917 ATP binding site [chemical binding]; other site 246196016918 Walker A motif; other site 246196016919 hexamer interface [polypeptide binding]; other site 246196016920 Walker B motif; other site 246196016921 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 246196016922 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 246196016923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196016924 motif II; other site 246196016925 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196016926 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196016927 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196016928 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 246196016929 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 246196016930 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 246196016931 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 246196016932 active site 246196016933 intersubunit interface [polypeptide binding]; other site 246196016934 catalytic residue [active] 246196016935 galactonate dehydratase; Provisional; Region: PRK14017 246196016936 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 246196016937 putative active site pocket [active] 246196016938 putative metal binding site [ion binding]; other site 246196016939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196016940 D-galactonate transporter; Region: 2A0114; TIGR00893 246196016941 putative substrate translocation pore; other site 246196016942 acetyl-CoA synthetase; Provisional; Region: PRK00174 246196016943 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 246196016944 active site 246196016945 CoA binding site [chemical binding]; other site 246196016946 acyl-activating enzyme (AAE) consensus motif; other site 246196016947 AMP binding site [chemical binding]; other site 246196016948 acetate binding site [chemical binding]; other site 246196016949 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 246196016950 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196016951 PGAP1-like protein; Region: PGAP1; pfam07819 246196016952 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246196016953 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246196016954 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 246196016955 putative active site [active] 246196016956 putative CoA binding site [chemical binding]; other site 246196016957 nudix motif; other site 246196016958 metal binding site [ion binding]; metal-binding site 246196016959 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246196016960 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246196016961 catalytic residues [active] 246196016962 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 246196016963 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246196016964 minor groove reading motif; other site 246196016965 helix-hairpin-helix signature motif; other site 246196016966 substrate binding pocket [chemical binding]; other site 246196016967 active site 246196016968 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 246196016969 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196016970 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196016971 ligand binding site [chemical binding]; other site 246196016972 flexible hinge region; other site 246196016973 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 246196016974 putative switch regulator; other site 246196016975 non-specific DNA interactions [nucleotide binding]; other site 246196016976 DNA binding site [nucleotide binding] 246196016977 sequence specific DNA binding site [nucleotide binding]; other site 246196016978 putative cAMP binding site [chemical binding]; other site 246196016979 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196016980 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246196016981 homotrimer interaction site [polypeptide binding]; other site 246196016982 putative active site [active] 246196016983 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 246196016984 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 246196016985 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246196016986 P loop; other site 246196016987 Nucleotide binding site [chemical binding]; other site 246196016988 DTAP/Switch II; other site 246196016989 Switch I; other site 246196016990 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 246196016991 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246196016992 DTAP/Switch II; other site 246196016993 Switch I; other site 246196016994 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196016995 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 246196016996 Amino acid permease; Region: AA_permease_2; pfam13520 246196016997 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Uncharacterized Proteins with similarity to Ornithine and Diaminopimelate Decarboxylases; Region: PLPDE_III_ODC_DapDC_like_1; cd06836 246196016998 dimer interface [polypeptide binding]; other site 246196016999 diaminopimelate decarboxylase; Region: lysA; TIGR01048 246196017000 active site 246196017001 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196017002 catalytic residues [active] 246196017003 substrate binding site [chemical binding]; other site 246196017004 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 246196017005 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196017006 Transcription factor WhiB; Region: Whib; pfam02467 246196017007 Transglycosylase; Region: Transgly; pfam00912 246196017008 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 246196017009 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 246196017010 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196017011 phosphodiesterase YaeI; Provisional; Region: PRK11340 246196017012 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246196017013 putative active site [active] 246196017014 putative metal binding site [ion binding]; other site 246196017015 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 246196017016 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 246196017017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196017018 catalytic residue [active] 246196017019 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196017020 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196017021 active site 246196017022 ATP binding site [chemical binding]; other site 246196017023 substrate binding site [chemical binding]; other site 246196017024 activation loop (A-loop); other site 246196017025 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 246196017026 putative hydrophobic ligand binding site [chemical binding]; other site 246196017027 protein interface [polypeptide binding]; other site 246196017028 gate; other site 246196017029 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196017030 acyl-CoA thioesterase II; Region: tesB; TIGR00189 246196017031 active site 246196017032 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196017033 catalytic triad [active] 246196017034 dimer interface [polypeptide binding]; other site 246196017035 Hemerythrin-like domain; Region: Hr-like; cd12108 246196017036 Fe binding site [ion binding]; other site 246196017037 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 246196017038 dimanganese center [ion binding]; other site 246196017039 Yqey-like protein; Region: YqeY; pfam09424 246196017040 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 246196017041 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 246196017042 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 246196017043 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196017044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196017045 Walker A motif; other site 246196017046 ATP binding site [chemical binding]; other site 246196017047 Walker B motif; other site 246196017048 arginine finger; other site 246196017049 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246196017050 Protein of unknown function DUF58; Region: DUF58; pfam01882 246196017051 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 246196017052 Predicted membrane protein/domain [Function unknown]; Region: COG1714 246196017053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017054 putative substrate translocation pore; other site 246196017055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017056 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 246196017057 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 246196017058 Predicted transcriptional regulators [Transcription]; Region: COG1695 246196017059 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 246196017060 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 246196017061 Predicted transcriptional regulators [Transcription]; Region: COG1695 246196017062 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 246196017063 glycerol kinase; Provisional; Region: glpK; PRK00047 246196017064 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 246196017065 N- and C-terminal domain interface [polypeptide binding]; other site 246196017066 active site 246196017067 MgATP binding site [chemical binding]; other site 246196017068 catalytic site [active] 246196017069 metal binding site [ion binding]; metal-binding site 246196017070 putative homotetramer interface [polypeptide binding]; other site 246196017071 glycerol binding site [chemical binding]; other site 246196017072 homodimer interface [polypeptide binding]; other site 246196017073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017074 S-adenosylmethionine binding site [chemical binding]; other site 246196017075 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196017076 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 246196017077 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 246196017078 tetramer interface [polypeptide binding]; other site 246196017079 heme binding pocket [chemical binding]; other site 246196017080 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196017081 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246196017082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017083 S-adenosylmethionine binding site [chemical binding]; other site 246196017084 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196017085 Methyltransferase domain; Region: Methyltransf_11; pfam08241 246196017086 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196017087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196017088 active site 246196017089 phosphorylation site [posttranslational modification] 246196017090 intermolecular recognition site; other site 246196017091 dimerization interface [polypeptide binding]; other site 246196017092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196017093 DNA binding residues [nucleotide binding] 246196017094 dimerization interface [polypeptide binding]; other site 246196017095 GAF domain; Region: GAF; pfam01590 246196017096 GAF domain; Region: GAF_2; pfam13185 246196017097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196017098 Histidine kinase; Region: HisKA_3; pfam07730 246196017099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196017100 ATP binding site [chemical binding]; other site 246196017101 Mg2+ binding site [ion binding]; other site 246196017102 G-X-G motif; other site 246196017103 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 246196017104 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 246196017105 active site 246196017106 NAD binding site [chemical binding]; other site 246196017107 metal binding site [ion binding]; metal-binding site 246196017108 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 246196017109 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196017110 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 246196017111 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 246196017112 dimer interface [polypeptide binding]; other site 246196017113 active site 246196017114 metal binding site [ion binding]; metal-binding site 246196017115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 246196017116 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196017117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017119 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196017120 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 246196017121 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246196017122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196017123 catalytic residue [active] 246196017124 Uncharacterized conserved protein [Function unknown]; Region: COG4301 246196017125 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 246196017126 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 246196017127 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 246196017128 putative active site [active] 246196017129 putative dimer interface [polypeptide binding]; other site 246196017130 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 246196017131 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246196017132 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 246196017133 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196017134 ferric uptake regulator; Provisional; Region: fur; PRK09462 246196017135 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246196017136 metal binding site 2 [ion binding]; metal-binding site 246196017137 putative DNA binding helix; other site 246196017138 metal binding site 1 [ion binding]; metal-binding site 246196017139 dimer interface [polypeptide binding]; other site 246196017140 structural Zn2+ binding site [ion binding]; other site 246196017141 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196017142 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 246196017143 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246196017144 aspartate kinase; Reviewed; Region: PRK06635 246196017145 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 246196017146 putative nucleotide binding site [chemical binding]; other site 246196017147 putative catalytic residues [active] 246196017148 putative Mg ion binding site [ion binding]; other site 246196017149 putative aspartate binding site [chemical binding]; other site 246196017150 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 246196017151 putative allosteric regulatory site; other site 246196017152 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 246196017153 putative allosteric regulatory residue; other site 246196017154 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196017155 dimer interface [polypeptide binding]; other site 246196017156 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 246196017157 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 246196017158 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246196017159 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196017160 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 246196017161 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 246196017162 putative active site [active] 246196017163 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 246196017164 domain_subunit interface; other site 246196017165 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246196017166 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 246196017167 active site 246196017168 FMN binding site [chemical binding]; other site 246196017169 substrate binding site [chemical binding]; other site 246196017170 3Fe-4S cluster binding site [ion binding]; other site 246196017171 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196017172 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246196017173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196017174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196017175 non-specific DNA binding site [nucleotide binding]; other site 246196017176 salt bridge; other site 246196017177 sequence-specific DNA binding site [nucleotide binding]; other site 246196017178 Cupin domain; Region: Cupin_2; pfam07883 246196017179 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 246196017180 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 246196017181 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 246196017182 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 246196017183 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 246196017184 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 246196017185 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 246196017186 MgtE intracellular N domain; Region: MgtE_N; pfam03448 246196017187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 246196017188 Divalent cation transporter; Region: MgtE; cl00786 246196017189 2-isopropylmalate synthase; Validated; Region: PRK03739 246196017190 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 246196017191 active site 246196017192 catalytic residues [active] 246196017193 metal binding site [ion binding]; metal-binding site 246196017194 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 246196017195 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 246196017196 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 246196017197 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 246196017198 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 246196017199 active site 246196017200 catalytic site [active] 246196017201 substrate binding site [chemical binding]; other site 246196017202 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 246196017203 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196017204 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 246196017205 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 246196017206 catalytic triad [active] 246196017207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196017208 recombination protein RecR; Reviewed; Region: recR; PRK00076 246196017209 RecR protein; Region: RecR; pfam02132 246196017210 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 246196017211 putative active site [active] 246196017212 putative metal-binding site [ion binding]; other site 246196017213 tetramer interface [polypeptide binding]; other site 246196017214 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 246196017215 hydrophobic ligand binding site; other site 246196017216 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196017217 FAD binding domain; Region: FAD_binding_4; pfam01565 246196017218 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 246196017219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017220 S-adenosylmethionine binding site [chemical binding]; other site 246196017221 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 246196017222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196017223 Walker A motif; other site 246196017224 ATP binding site [chemical binding]; other site 246196017225 Walker B motif; other site 246196017226 arginine finger; other site 246196017227 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 246196017228 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 246196017229 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196017230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196017231 homodimer interface [polypeptide binding]; other site 246196017232 catalytic residue [active] 246196017233 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246196017234 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246196017235 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246196017236 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196017237 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196017238 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196017239 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246196017240 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 246196017241 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246196017242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017244 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196017245 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196017246 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196017247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017248 putative substrate translocation pore; other site 246196017249 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 246196017250 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196017251 catalytic Zn binding site [ion binding]; other site 246196017252 structural Zn binding site [ion binding]; other site 246196017253 tetramer interface [polypeptide binding]; other site 246196017254 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196017255 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 246196017256 NAD(P) binding site [chemical binding]; other site 246196017257 catalytic residues [active] 246196017258 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196017259 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 246196017260 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 246196017261 dimerization interface [polypeptide binding]; other site 246196017262 ligand binding site [chemical binding]; other site 246196017263 NADP binding site [chemical binding]; other site 246196017264 catalytic site [active] 246196017265 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196017266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196017267 DNA-binding site [nucleotide binding]; DNA binding site 246196017268 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196017269 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 246196017270 nucleotide binding site [chemical binding]; other site 246196017271 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 246196017272 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 246196017273 active site 246196017274 DNA binding site [nucleotide binding] 246196017275 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 246196017276 DNA binding site [nucleotide binding] 246196017277 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 246196017278 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 246196017279 active site 246196017280 DNA binding site [nucleotide binding] 246196017281 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 246196017282 DNA binding site [nucleotide binding] 246196017283 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246196017284 Carboxylesterase family; Region: COesterase; pfam00135 246196017285 substrate binding pocket [chemical binding]; other site 246196017286 catalytic triad [active] 246196017287 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 246196017288 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 246196017289 active site 246196017290 HIGH motif; other site 246196017291 nucleotide binding site [chemical binding]; other site 246196017292 active site 246196017293 KMSKS motif; other site 246196017294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196017295 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196017296 substrate binding pocket [chemical binding]; other site 246196017297 membrane-bound complex binding site; other site 246196017298 hinge residues; other site 246196017299 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246196017300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017301 dimer interface [polypeptide binding]; other site 246196017302 conserved gate region; other site 246196017303 putative PBP binding loops; other site 246196017304 ABC-ATPase subunit interface; other site 246196017305 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196017306 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196017307 Walker A/P-loop; other site 246196017308 ATP binding site [chemical binding]; other site 246196017309 Q-loop/lid; other site 246196017310 ABC transporter signature motif; other site 246196017311 Walker B; other site 246196017312 D-loop; other site 246196017313 H-loop/switch region; other site 246196017314 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 246196017315 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 246196017316 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 246196017317 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 246196017318 NAD(P) binding pocket [chemical binding]; other site 246196017319 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196017320 Cytochrome P450; Region: p450; cl12078 246196017321 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 246196017322 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 246196017323 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 246196017324 haloalkane dehalogenase; Provisional; Region: PRK00870 246196017325 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 246196017326 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 246196017327 active site 246196017328 catalytic triad [active] 246196017329 oxyanion hole [active] 246196017330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196017331 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 246196017332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196017333 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 246196017334 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 246196017335 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 246196017336 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 246196017337 alpha-beta subunit interface [polypeptide binding]; other site 246196017338 alpha-gamma subunit interface [polypeptide binding]; other site 246196017339 active site 246196017340 substrate and K+ binding site; other site 246196017341 K+ binding site [ion binding]; other site 246196017342 cobalamin binding site [chemical binding]; other site 246196017343 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 246196017344 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196017345 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196017346 alpha-dioxygenase; Region: PLN02283 246196017347 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 246196017348 putative heme binding site [chemical binding]; other site 246196017349 putative active site [active] 246196017350 putative substrate binding site [chemical binding]; other site 246196017351 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 246196017352 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246196017353 nucleoside/Zn binding site; other site 246196017354 dimer interface [polypeptide binding]; other site 246196017355 catalytic motif [active] 246196017356 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 246196017357 prephenate dehydrogenase; Validated; Region: PRK06545 246196017358 prephenate dehydrogenase; Validated; Region: PRK08507 246196017359 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 246196017360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017361 ABC-ATPase subunit interface; other site 246196017362 putative PBP binding loops; other site 246196017363 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 246196017364 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 246196017365 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 246196017366 Walker A/P-loop; other site 246196017367 ATP binding site [chemical binding]; other site 246196017368 Q-loop/lid; other site 246196017369 ABC transporter signature motif; other site 246196017370 Walker B; other site 246196017371 D-loop; other site 246196017372 H-loop/switch region; other site 246196017373 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 246196017374 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 246196017375 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196017376 putative active site [active] 246196017377 putative substrate binding site [chemical binding]; other site 246196017378 ATP binding site [chemical binding]; other site 246196017379 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196017380 catalytic core [active] 246196017381 short chain dehydrogenase; Provisional; Region: PRK07035 246196017382 classical (c) SDRs; Region: SDR_c; cd05233 246196017383 NAD(P) binding site [chemical binding]; other site 246196017384 active site 246196017385 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 246196017386 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196017387 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196017388 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196017389 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196017390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196017391 dimerization interface [polypeptide binding]; other site 246196017392 putative Zn2+ binding site [ion binding]; other site 246196017393 putative DNA binding site [nucleotide binding]; other site 246196017394 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 246196017395 active site 246196017396 metal binding site [ion binding]; metal-binding site 246196017397 homotetramer interface [polypeptide binding]; other site 246196017398 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 246196017399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196017400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196017401 homodimer interface [polypeptide binding]; other site 246196017402 catalytic residue [active] 246196017403 GXWXG protein; Region: GXWXG; pfam14231 246196017404 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 246196017405 enoyl-CoA hydratase; Provisional; Region: PRK06142 246196017406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196017407 substrate binding site [chemical binding]; other site 246196017408 oxyanion hole (OAH) forming residues; other site 246196017409 trimer interface [polypeptide binding]; other site 246196017410 Cutinase; Region: Cutinase; pfam01083 246196017411 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246196017412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196017413 MarR family; Region: MarR_2; cl17246 246196017414 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 246196017415 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 246196017416 NAD(P) binding site [chemical binding]; other site 246196017417 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246196017418 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196017419 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196017420 catalytic residue [active] 246196017421 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 246196017422 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 246196017423 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 246196017424 Walker A/P-loop; other site 246196017425 ATP binding site [chemical binding]; other site 246196017426 Q-loop/lid; other site 246196017427 ABC transporter signature motif; other site 246196017428 Walker B; other site 246196017429 D-loop; other site 246196017430 H-loop/switch region; other site 246196017431 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246196017432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196017433 active site 246196017434 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 246196017435 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246196017436 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 246196017437 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196017438 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196017439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196017440 DNA-binding site [nucleotide binding]; DNA binding site 246196017441 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196017442 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196017443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196017444 homodimer interface [polypeptide binding]; other site 246196017445 catalytic residue [active] 246196017446 Predicted membrane protein [Function unknown]; Region: COG2246 246196017447 GtrA-like protein; Region: GtrA; pfam04138 246196017448 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 246196017449 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 246196017450 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 246196017451 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 246196017452 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 246196017453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017454 putative substrate translocation pore; other site 246196017455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196017456 DNA binding site [nucleotide binding] 246196017457 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196017458 domain linker motif; other site 246196017459 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196017460 dimerization interface [polypeptide binding]; other site 246196017461 ligand binding site [chemical binding]; other site 246196017462 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196017463 benzoate transport; Region: 2A0115; TIGR00895 246196017464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017465 putative substrate translocation pore; other site 246196017466 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 246196017467 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196017468 FAD binding domain; Region: FAD_binding_4; pfam01565 246196017469 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 246196017470 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246196017471 metal binding site 2 [ion binding]; metal-binding site 246196017472 putative DNA binding helix; other site 246196017473 metal binding site 1 [ion binding]; metal-binding site 246196017474 dimer interface [polypeptide binding]; other site 246196017475 structural Zn2+ binding site [ion binding]; other site 246196017476 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 246196017477 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 246196017478 dimer interface [polypeptide binding]; other site 246196017479 active site 246196017480 heme binding site [chemical binding]; other site 246196017481 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 246196017482 short chain dehydrogenase; Provisional; Region: PRK07904 246196017483 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196017484 NAD(P) binding site [chemical binding]; other site 246196017485 active site 246196017486 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 246196017487 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 246196017488 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 246196017489 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 246196017490 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 246196017491 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196017492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017493 putative substrate translocation pore; other site 246196017494 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196017495 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196017496 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196017497 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196017498 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196017499 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246196017500 active site 246196017501 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246196017502 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196017503 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196017504 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 246196017505 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 246196017506 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196017507 acyl-activating enzyme (AAE) consensus motif; other site 246196017508 active site 246196017509 Cutinase; Region: Cutinase; pfam01083 246196017510 Predicted esterase [General function prediction only]; Region: COG0627 246196017511 Putative esterase; Region: Esterase; pfam00756 246196017512 Putative esterase; Region: Esterase; pfam00756 246196017513 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 246196017514 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 246196017515 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246196017516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196017517 active site 246196017518 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 246196017519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196017520 UDP-galactopyranose mutase; Region: GLF; pfam03275 246196017521 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 246196017522 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 246196017523 amidase catalytic site [active] 246196017524 Zn binding residues [ion binding]; other site 246196017525 substrate binding site [chemical binding]; other site 246196017526 LGFP repeat; Region: LGFP; pfam08310 246196017527 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 246196017528 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246196017529 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246196017530 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196017531 putative acyl-acceptor binding pocket; other site 246196017532 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246196017533 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196017534 putative acyl-acceptor binding pocket; other site 246196017535 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196017536 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246196017537 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196017538 iron-sulfur cluster [ion binding]; other site 246196017539 [2Fe-2S] cluster binding site [ion binding]; other site 246196017540 seryl-tRNA synthetase; Provisional; Region: PRK05431 246196017541 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 246196017542 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 246196017543 dimer interface [polypeptide binding]; other site 246196017544 active site 246196017545 motif 1; other site 246196017546 motif 2; other site 246196017547 motif 3; other site 246196017548 Septum formation; Region: Septum_form; pfam13845 246196017549 Septum formation; Region: Septum_form; pfam13845 246196017550 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 246196017551 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196017552 catalytic core [active] 246196017553 prephenate dehydratase; Provisional; Region: PRK11898 246196017554 Prephenate dehydratase; Region: PDT; pfam00800 246196017555 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 246196017556 putative L-Phe binding site [chemical binding]; other site 246196017557 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 246196017558 CAAX protease self-immunity; Region: Abi; pfam02517 246196017559 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 246196017560 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 246196017561 Ferritin-like domain; Region: Ferritin; pfam00210 246196017562 ferroxidase diiron center [ion binding]; other site 246196017563 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 246196017564 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 246196017565 putative active site [active] 246196017566 catalytic site [active] 246196017567 putative metal binding site [ion binding]; other site 246196017568 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 246196017569 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196017570 active site residue [active] 246196017571 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 246196017572 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 246196017573 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 246196017574 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196017575 CopC domain; Region: CopC; pfam04234 246196017576 Copper resistance protein D; Region: CopD; cl00563 246196017577 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 246196017578 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196017579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196017580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017582 DNA polymerase IV; Validated; Region: PRK03858 246196017583 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246196017584 active site 246196017585 DNA binding site [nucleotide binding] 246196017586 yiaA/B two helix domain; Region: YiaAB; cl01759 246196017587 hypothetical protein; Provisional; Region: PRK07945 246196017588 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 246196017589 active site 246196017590 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196017591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196017592 dimerization interface [polypeptide binding]; other site 246196017593 putative DNA binding site [nucleotide binding]; other site 246196017594 putative Zn2+ binding site [ion binding]; other site 246196017595 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 246196017596 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246196017597 Sulfate transporter family; Region: Sulfate_transp; pfam00916 246196017598 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 246196017599 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 246196017600 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 246196017601 NAD(P) binding site [chemical binding]; other site 246196017602 catalytic residues [active] 246196017603 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196017604 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196017605 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 246196017606 Moco binding site; other site 246196017607 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 246196017608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196017609 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 246196017610 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 246196017611 active site 246196017612 dimer interface [polypeptide binding]; other site 246196017613 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 246196017614 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246196017615 active site 246196017616 FMN binding site [chemical binding]; other site 246196017617 substrate binding site [chemical binding]; other site 246196017618 3Fe-4S cluster binding site [ion binding]; other site 246196017619 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 246196017620 domain interface; other site 246196017621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196017622 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196017623 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196017624 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196017625 active site 2 [active] 246196017626 active site 1 [active] 246196017627 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196017628 CoenzymeA binding site [chemical binding]; other site 246196017629 subunit interaction site [polypeptide binding]; other site 246196017630 PHB binding site; other site 246196017631 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 246196017632 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 246196017633 Cl- selectivity filter; other site 246196017634 Cl- binding residues [ion binding]; other site 246196017635 pore gating glutamate residue; other site 246196017636 dimer interface [polypeptide binding]; other site 246196017637 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 246196017638 amphipathic channel; other site 246196017639 Asn-Pro-Ala signature motifs; other site 246196017640 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 246196017641 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 246196017642 dimerization interface [polypeptide binding]; other site 246196017643 DPS ferroxidase diiron center [ion binding]; other site 246196017644 ion pore; other site 246196017645 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 246196017646 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246196017647 minor groove reading motif; other site 246196017648 helix-hairpin-helix signature motif; other site 246196017649 active site 246196017650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 246196017651 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 246196017652 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196017653 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196017654 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 246196017655 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 246196017656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017657 NAD(P) binding site [chemical binding]; other site 246196017658 active site 246196017659 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196017660 methionine sulfoxide reductase A; Provisional; Region: PRK14054 246196017661 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196017662 Cytochrome P450; Region: p450; cl12078 246196017663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017666 Methyltransferase domain; Region: Methyltransf_24; pfam13578 246196017667 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 246196017668 Protein of unknown function, DUF608; Region: DUF608; pfam04685 246196017669 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196017670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017671 S-adenosylmethionine binding site [chemical binding]; other site 246196017672 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196017673 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196017674 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196017675 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 246196017676 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 246196017677 active site 246196017678 FMN binding site [chemical binding]; other site 246196017679 substrate binding site [chemical binding]; other site 246196017680 homotetramer interface [polypeptide binding]; other site 246196017681 catalytic residue [active] 246196017682 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196017683 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 246196017684 hypothetical protein; Provisional; Region: PRK07236 246196017685 benzoate transport; Region: 2A0115; TIGR00895 246196017686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017688 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196017689 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 246196017690 NAD(P) binding site [chemical binding]; other site 246196017691 catalytic residues [active] 246196017692 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196017693 GAF domain; Region: GAF; pfam01590 246196017694 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 246196017695 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196017696 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196017697 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196017698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017699 putative PBP binding loops; other site 246196017700 ABC-ATPase subunit interface; other site 246196017701 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196017702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017703 dimer interface [polypeptide binding]; other site 246196017704 conserved gate region; other site 246196017705 putative PBP binding loops; other site 246196017706 ABC-ATPase subunit interface; other site 246196017707 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196017708 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196017709 Walker A/P-loop; other site 246196017710 ATP binding site [chemical binding]; other site 246196017711 Q-loop/lid; other site 246196017712 ABC transporter signature motif; other site 246196017713 Walker B; other site 246196017714 D-loop; other site 246196017715 H-loop/switch region; other site 246196017716 Domain of unknown function (DUF427); Region: DUF427; cl00998 246196017717 putative transcriptional regulator; Provisional; Region: PRK11640 246196017718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017719 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 246196017720 putative FMN binding site [chemical binding]; other site 246196017721 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 246196017722 Isochorismatase family; Region: Isochorismatase; pfam00857 246196017723 catalytic triad [active] 246196017724 metal binding site [ion binding]; metal-binding site 246196017725 conserved cis-peptide bond; other site 246196017726 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 246196017727 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 246196017728 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 246196017729 active site 246196017730 catalytic site [active] 246196017731 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196017732 MarR family; Region: MarR_2; pfam12802 246196017733 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 246196017734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017735 Walker A/P-loop; other site 246196017736 ATP binding site [chemical binding]; other site 246196017737 Q-loop/lid; other site 246196017738 ABC transporter signature motif; other site 246196017739 Walker B; other site 246196017740 D-loop; other site 246196017741 H-loop/switch region; other site 246196017742 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246196017743 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196017744 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 246196017745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017746 active site 246196017747 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 246196017748 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196017749 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196017750 active site 246196017751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017752 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 246196017753 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 246196017754 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 246196017755 trehalose synthase; Region: treS_nterm; TIGR02456 246196017756 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 246196017757 active site 246196017758 catalytic site [active] 246196017759 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 246196017760 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 246196017761 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 246196017762 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196017763 active site 246196017764 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196017765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017766 Walker A/P-loop; other site 246196017767 ATP binding site [chemical binding]; other site 246196017768 Q-loop/lid; other site 246196017769 ABC transporter signature motif; other site 246196017770 Walker B; other site 246196017771 D-loop; other site 246196017772 H-loop/switch region; other site 246196017773 TOBE domain; Region: TOBE_2; pfam08402 246196017774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017775 dimer interface [polypeptide binding]; other site 246196017776 conserved gate region; other site 246196017777 putative PBP binding loops; other site 246196017778 ABC-ATPase subunit interface; other site 246196017779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 246196017780 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 246196017781 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246196017782 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 246196017783 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 246196017784 Subunit I/III interface [polypeptide binding]; other site 246196017785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017787 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246196017788 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 246196017789 elongation factor G; Reviewed; Region: PRK12740 246196017790 G1 box; other site 246196017791 putative GEF interaction site [polypeptide binding]; other site 246196017792 GTP/Mg2+ binding site [chemical binding]; other site 246196017793 Switch I region; other site 246196017794 G2 box; other site 246196017795 G3 box; other site 246196017796 Switch II region; other site 246196017797 G4 box; other site 246196017798 G5 box; other site 246196017799 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 246196017800 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 246196017801 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 246196017802 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196017803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017805 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196017806 classical (c) SDRs; Region: SDR_c; cd05233 246196017807 NAD(P) binding site [chemical binding]; other site 246196017808 active site 246196017809 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196017810 mce related protein; Region: MCE; pfam02470 246196017811 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196017812 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 246196017813 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246196017814 anti sigma factor interaction site; other site 246196017815 regulatory phosphorylation site [posttranslational modification]; other site 246196017816 B12 binding domain; Region: B12-binding_2; pfam02607 246196017817 B12 binding domain; Region: B12-binding; pfam02310 246196017818 B12 binding site [chemical binding]; other site 246196017819 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 246196017820 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196017821 catalytic core [active] 246196017822 Cupin domain; Region: Cupin_2; cl17218 246196017823 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196017824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196017825 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196017826 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246196017827 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 246196017828 iron-sulfur cluster [ion binding]; other site 246196017829 [2Fe-2S] cluster binding site [ion binding]; other site 246196017830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017831 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246196017832 Walker A/P-loop; other site 246196017833 ATP binding site [chemical binding]; other site 246196017834 Q-loop/lid; other site 246196017835 ABC transporter signature motif; other site 246196017836 Walker B; other site 246196017837 D-loop; other site 246196017838 H-loop/switch region; other site 246196017839 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 246196017840 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246196017841 FAD binding pocket [chemical binding]; other site 246196017842 FAD binding motif [chemical binding]; other site 246196017843 phosphate binding motif [ion binding]; other site 246196017844 NAD binding pocket [chemical binding]; other site 246196017845 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196017846 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196017847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017848 Walker A/P-loop; other site 246196017849 ATP binding site [chemical binding]; other site 246196017850 Q-loop/lid; other site 246196017851 ABC transporter signature motif; other site 246196017852 Walker B; other site 246196017853 D-loop; other site 246196017854 H-loop/switch region; other site 246196017855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017858 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196017859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196017860 substrate binding site [chemical binding]; other site 246196017861 oxyanion hole (OAH) forming residues; other site 246196017862 trimer interface [polypeptide binding]; other site 246196017863 short chain dehydrogenase; Provisional; Region: PRK06197 246196017864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017865 NAD(P) binding site [chemical binding]; other site 246196017866 active site 246196017867 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 246196017868 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196017869 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196017870 active site 246196017871 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196017872 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017875 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017876 active site 246196017877 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 246196017878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017879 NAD(P) binding site [chemical binding]; other site 246196017880 active site 246196017881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196017884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196017885 Coenzyme A binding pocket [chemical binding]; other site 246196017886 PAS domain; Region: PAS_9; pfam13426 246196017887 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 246196017888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196017889 DNA binding residues [nucleotide binding] 246196017890 dimerization interface [polypeptide binding]; other site 246196017891 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 246196017892 Protein of unknown function (DUF461); Region: DUF461; pfam04314 246196017893 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 246196017894 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 246196017895 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 246196017896 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 246196017897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017898 S-adenosylmethionine binding site [chemical binding]; other site 246196017899 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196017900 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 246196017901 heme-binding site [chemical binding]; other site 246196017902 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196017903 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196017904 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196017905 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196017906 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196017907 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246196017908 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196017909 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196017910 short chain dehydrogenase; Validated; Region: PRK08264 246196017911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017912 NAD(P) binding site [chemical binding]; other site 246196017913 active site 246196017914 S-formylglutathione hydrolase; Region: PLN02442 246196017915 Putative esterase; Region: Esterase; pfam00756 246196017916 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 246196017917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017919 active site 246196017920 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017921 active site 246196017922 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017923 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196017924 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196017925 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 246196017926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196017927 ATP binding site [chemical binding]; other site 246196017928 putative Mg++ binding site [ion binding]; other site 246196017929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196017930 nucleotide binding region [chemical binding]; other site 246196017931 Helicase associated domain (HA2); Region: HA2; pfam04408 246196017932 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 246196017933 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 246196017934 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196017935 Winged helix-turn helix; Region: HTH_29; pfam13551 246196017936 Homeodomain-like domain; Region: HTH_32; pfam13565 246196017937 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196017938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 246196017939 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 246196017940 SnoaL-like domain; Region: SnoaL_3; pfam13474 246196017941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017942 NAD(P) binding site [chemical binding]; other site 246196017943 active site 246196017944 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246196017945 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246196017946 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196017947 catalytic residue [active] 246196017948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 246196017949 YheO-like PAS domain; Region: PAS_6; pfam08348 246196017950 HTH domain; Region: HTH_22; pfam13309 246196017951 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196017952 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196017953 Walker A/P-loop; other site 246196017954 ATP binding site [chemical binding]; other site 246196017955 Q-loop/lid; other site 246196017956 ABC transporter signature motif; other site 246196017957 Walker B; other site 246196017958 D-loop; other site 246196017959 H-loop/switch region; other site 246196017960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017961 dimer interface [polypeptide binding]; other site 246196017962 conserved gate region; other site 246196017963 putative PBP binding loops; other site 246196017964 ABC-ATPase subunit interface; other site 246196017965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196017966 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196017967 substrate binding pocket [chemical binding]; other site 246196017968 membrane-bound complex binding site; other site 246196017969 hinge residues; other site 246196017970 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246196017971 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196017972 riboflavin synthase subunit beta; Provisional; Region: PRK12419 246196017973 active site 246196017974 homopentamer interface [polypeptide binding]; other site 246196017975 potential frameshift: common BLAST hit: gi|119866668|ref|YP_936620.1| LuxR family transcriptional regulator 246196017976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196017977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196017978 DNA binding residues [nucleotide binding] 246196017979 dimerization interface [polypeptide binding]; other site 246196017980 Homeodomain-like domain; Region: HTH_23; cl17451 246196017981 Winged helix-turn helix; Region: HTH_29; pfam13551 246196017982 Integrase core domain; Region: rve; pfam00665 246196017983 Integrase core domain; Region: rve_3; pfam13683 246196017984 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 246196017985 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196017986 Predicted transcriptional regulators [Transcription]; Region: COG1695 246196017987 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 246196017988 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 246196017989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017991 von Willebrand factor type A domain; Region: VWA_2; pfam13519 246196017992 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 246196017993 Protein of unknown function DUF58; Region: DUF58; pfam01882 246196017994 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196017995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196017996 ATP binding site [chemical binding]; other site 246196017997 Walker A motif; other site 246196017998 Walker B motif; other site 246196017999 arginine finger; other site 246196018000 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246196018001 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246196018002 putative active site [active] 246196018003 putative metal binding site [ion binding]; other site 246196018004 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 246196018005 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246196018006 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 246196018007 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196018008 NAD binding site [chemical binding]; other site 246196018009 catalytic Zn binding site [ion binding]; other site 246196018010 structural Zn binding site [ion binding]; other site 246196018011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196018012 ATP binding site [chemical binding]; other site 246196018013 putative Mg++ binding site [ion binding]; other site 246196018014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196018015 nucleotide binding region [chemical binding]; other site 246196018016 ATP-binding site [chemical binding]; other site 246196018017 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 246196018018 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 246196018019 putative active site [active] 246196018020 putative CoA binding site [chemical binding]; other site 246196018021 nudix motif; other site 246196018022 metal binding site [ion binding]; metal-binding site 246196018023 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 246196018024 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196018025 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196018026 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196018027 Cytochrome P450; Region: p450; cl12078 246196018028 classical (c) SDRs; Region: SDR_c; cd05233 246196018029 NAD(P) binding site [chemical binding]; other site 246196018030 active site 246196018031 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196018032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196018033 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196018034 active site 246196018035 metal binding site [ion binding]; metal-binding site 246196018036 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246196018037 classical (c) SDRs; Region: SDR_c; cd05233 246196018038 NAD(P) binding site [chemical binding]; other site 246196018039 active site 246196018040 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 246196018041 FMN binding site [chemical binding]; other site 246196018042 dimer interface [polypeptide binding]; other site 246196018043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196018044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018045 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196018046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196018047 active site 246196018048 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 246196018049 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246196018050 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 246196018051 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 246196018052 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 246196018053 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 246196018054 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 246196018055 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 246196018056 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 246196018057 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 246196018058 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 246196018059 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 246196018060 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 246196018061 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 246196018062 THF binding site; other site 246196018063 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 246196018064 substrate binding site [chemical binding]; other site 246196018065 THF binding site; other site 246196018066 zinc-binding site [ion binding]; other site 246196018067 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018069 DNA-binding site [nucleotide binding]; DNA binding site 246196018070 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196018071 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196018072 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196018073 active site 246196018074 non-prolyl cis peptide bond; other site 246196018075 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196018076 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196018077 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196018078 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196018079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196018080 non-specific DNA binding site [nucleotide binding]; other site 246196018081 salt bridge; other site 246196018082 sequence-specific DNA binding site [nucleotide binding]; other site 246196018083 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 246196018084 Domain of unknown function (DUF955); Region: DUF955; pfam06114 246196018085 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 246196018086 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 246196018087 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 246196018088 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196018089 tetramer interface [polypeptide binding]; other site 246196018090 active site 246196018091 Mg2+/Mn2+ binding site [ion binding]; other site 246196018092 citrate synthase; Provisional; Region: PRK14033 246196018093 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 246196018094 dimer interface [polypeptide binding]; other site 246196018095 active site 246196018096 citrylCoA binding site [chemical binding]; other site 246196018097 oxalacetate/citrate binding site [chemical binding]; other site 246196018098 coenzyme A binding site [chemical binding]; other site 246196018099 catalytic triad [active] 246196018100 pyruvate carboxylase; Reviewed; Region: PRK12999 246196018101 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196018102 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196018103 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196018104 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 246196018105 active site 246196018106 catalytic residues [active] 246196018107 metal binding site [ion binding]; metal-binding site 246196018108 homodimer binding site [polypeptide binding]; other site 246196018109 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196018110 carboxyltransferase (CT) interaction site; other site 246196018111 biotinylation site [posttranslational modification]; other site 246196018112 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 246196018113 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196018114 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196018115 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196018116 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 246196018117 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 246196018118 DNA binding site [nucleotide binding] 246196018119 active site 246196018120 Int/Topo IB signature motif; other site 246196018121 catalytic residues [active] 246196018122 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 246196018123 Coenzyme A transferase; Region: CoA_trans; cl17247 246196018124 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018125 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196018126 catalytic site [active] 246196018127 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196018128 Na binding site [ion binding]; other site 246196018129 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196018130 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 246196018131 short chain dehydrogenase; Validated; Region: PRK08589 246196018132 classical (c) SDRs; Region: SDR_c; cd05233 246196018133 NAD(P) binding site [chemical binding]; other site 246196018134 active site 246196018135 Methyltransferase domain; Region: Methyltransf_11; pfam08241 246196018136 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 246196018137 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 246196018138 FAD binding site [chemical binding]; other site 246196018139 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 246196018140 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 246196018141 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246196018142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196018143 dimer interface [polypeptide binding]; other site 246196018144 conserved gate region; other site 246196018145 putative PBP binding loops; other site 246196018146 ABC-ATPase subunit interface; other site 246196018147 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196018148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196018149 dimer interface [polypeptide binding]; other site 246196018150 conserved gate region; other site 246196018151 putative PBP binding loops; other site 246196018152 ABC-ATPase subunit interface; other site 246196018153 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196018154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196018155 Walker A/P-loop; other site 246196018156 ATP binding site [chemical binding]; other site 246196018157 Q-loop/lid; other site 246196018158 ABC transporter signature motif; other site 246196018159 Walker B; other site 246196018160 D-loop; other site 246196018161 H-loop/switch region; other site 246196018162 TOBE domain; Region: TOBE_2; pfam08402 246196018163 Sulfatase; Region: Sulfatase; cl17466 246196018164 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 246196018165 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196018166 Amidase; Region: Amidase; cl11426 246196018167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196018168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018169 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 246196018170 substrate binding pocket [chemical binding]; other site 246196018171 dimerization interface [polypeptide binding]; other site 246196018172 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 246196018173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018174 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196018175 dimerization interface [polypeptide binding]; other site 246196018176 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196018177 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196018178 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246196018179 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196018180 AhpC/TSA family; Region: AhpC-TSA; pfam00578 246196018181 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246196018182 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 246196018183 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196018184 inhibitor-cofactor binding pocket; inhibition site 246196018185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196018186 catalytic residue [active] 246196018187 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196018188 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196018189 active site 246196018190 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196018191 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196018192 NAD(P) binding site [chemical binding]; other site 246196018193 catalytic residues [active] 246196018194 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196018195 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196018196 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196018197 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196018198 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 246196018199 conserved cys residue [active] 246196018200 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 246196018201 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 246196018202 catalytic triad [active] 246196018203 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196018204 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196018205 substrate binding pocket [chemical binding]; other site 246196018206 membrane-bound complex binding site; other site 246196018207 hinge residues; other site 246196018208 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196018209 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196018210 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246196018211 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196018212 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196018213 Cytochrome P450; Region: p450; cl12078 246196018214 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196018215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018216 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196018217 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 246196018218 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 246196018219 NAD(P) binding site [chemical binding]; other site 246196018220 catalytic residues [active] 246196018221 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196018222 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196018223 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196018224 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196018225 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 246196018226 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 246196018227 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 246196018228 shikimate binding site; other site 246196018229 NAD(P) binding site [chemical binding]; other site 246196018230 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018231 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196018232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196018233 NAD(P) binding site [chemical binding]; other site 246196018234 active site 246196018235 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 246196018236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018237 benzoate transport; Region: 2A0115; TIGR00895 246196018238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196018239 putative substrate translocation pore; other site 246196018240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196018241 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 246196018242 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 246196018243 active site 246196018244 dimer interface [polypeptide binding]; other site 246196018245 metal binding site [ion binding]; metal-binding site 246196018246 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 246196018247 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 246196018248 active site 246196018249 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196018250 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196018251 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196018252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196018253 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196018254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246196018255 benzoate transport; Region: 2A0115; TIGR00895 246196018256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196018257 putative substrate translocation pore; other site 246196018258 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018259 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246196018260 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018261 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196018262 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 246196018263 hypothetical protein; Provisional; Region: PRK06547 246196018264 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 246196018265 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196018266 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196018267 Walker A/P-loop; other site 246196018268 ATP binding site [chemical binding]; other site 246196018269 Q-loop/lid; other site 246196018270 ABC transporter signature motif; other site 246196018271 Walker B; other site 246196018272 D-loop; other site 246196018273 H-loop/switch region; other site 246196018274 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196018275 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196018276 Q-loop/lid; other site 246196018277 ABC transporter signature motif; other site 246196018278 Walker B; other site 246196018279 D-loop; other site 246196018280 H-loop/switch region; other site 246196018281 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 246196018282 amino acid transporter; Region: 2A0306; TIGR00909 246196018283 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 246196018284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196018285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196018286 active site 246196018287 catalytic tetrad [active] 246196018288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196018289 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196018290 salt bridge; other site 246196018291 non-specific DNA binding site [nucleotide binding]; other site 246196018292 sequence-specific DNA binding site [nucleotide binding]; other site 246196018293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196018294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018295 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 246196018296 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246196018297 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 246196018298 putative active site [active] 246196018299 catalytic triad [active] 246196018300 putative dimer interface [polypeptide binding]; other site 246196018301 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196018302 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196018303 active site 246196018304 non-prolyl cis peptide bond; other site 246196018305 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196018306 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196018307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196018308 DNA binding site [nucleotide binding] 246196018309 domain linker motif; other site 246196018310 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 246196018311 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196018312 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018314 DNA-binding site [nucleotide binding]; DNA binding site 246196018315 FCD domain; Region: FCD; pfam07729 246196018316 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 246196018317 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 246196018318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196018319 catalytic residue [active] 246196018320 ANTAR domain; Region: ANTAR; pfam03861 246196018321 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196018322 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196018323 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196018324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246196018325 active site 246196018326 metal binding site [ion binding]; metal-binding site 246196018327 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 246196018328 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196018329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018330 DNA-binding site [nucleotide binding]; DNA binding site 246196018331 UTRA domain; Region: UTRA; pfam07702 246196018332 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196018333 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196018334 active site 246196018335 catalytic tetrad [active] 246196018336 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196018337 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196018338 putative NAD(P) binding site [chemical binding]; other site 246196018339 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246196018340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196018341 Walker A/P-loop; other site 246196018342 ATP binding site [chemical binding]; other site 246196018343 ABC transporter signature motif; other site 246196018344 Walker B; other site 246196018345 D-loop; other site 246196018346 H-loop/switch region; other site 246196018347 ABC transporter; Region: ABC_tran_2; pfam12848 246196018348 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196018349 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 246196018350 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196018351 classical (c) SDRs; Region: SDR_c; cd05233 246196018352 NAD(P) binding site [chemical binding]; other site 246196018353 active site 246196018354 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196018355 active site 246196018356 catalytic site [active] 246196018357 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196018358 active site 2 [active] 246196018359 active site 1 [active] 246196018360 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 246196018361 NmrA-like family; Region: NmrA; pfam05368 246196018362 NAD(P) binding site [chemical binding]; other site 246196018363 active site lysine 246196018364 glycerol kinase; Provisional; Region: glpK; PRK00047 246196018365 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 246196018366 N- and C-terminal domain interface [polypeptide binding]; other site 246196018367 active site 246196018368 MgATP binding site [chemical binding]; other site 246196018369 catalytic site [active] 246196018370 metal binding site [ion binding]; metal-binding site 246196018371 putative homotetramer interface [polypeptide binding]; other site 246196018372 glycerol binding site [chemical binding]; other site 246196018373 homodimer interface [polypeptide binding]; other site 246196018374 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246196018375 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196018376 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196018377 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 246196018378 amphipathic channel; other site 246196018379 Asn-Pro-Ala signature motifs; other site 246196018380 glycerol kinase; Provisional; Region: glpK; PRK00047 246196018381 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196018382 nucleotide binding site [chemical binding]; other site 246196018383 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 246196018384 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 246196018385 putative hydrophobic ligand binding site [chemical binding]; other site 246196018386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196018387 dimerization interface [polypeptide binding]; other site 246196018388 putative DNA binding site [nucleotide binding]; other site 246196018389 putative Zn2+ binding site [ion binding]; other site 246196018390 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196018392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018393 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 246196018394 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246196018395 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196018396 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196018397 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196018398 Walker A/P-loop; other site 246196018399 ATP binding site [chemical binding]; other site 246196018400 Q-loop/lid; other site 246196018401 ABC transporter signature motif; other site 246196018402 Walker B; other site 246196018403 D-loop; other site 246196018404 H-loop/switch region; other site 246196018405 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246196018406 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196018407 active site 246196018408 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196018409 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246196018410 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246196018411 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246196018412 putative NADP binding site [chemical binding]; other site 246196018413 active site 246196018414 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196018415 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 246196018416 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 246196018417 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 246196018418 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 246196018419 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196018420 hypothetical protein; Validated; Region: PRK07581 246196018421 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 246196018422 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196018423 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246196018424 enoyl-CoA hydratase; Provisional; Region: PRK09245 246196018425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196018426 substrate binding site [chemical binding]; other site 246196018427 oxyanion hole (OAH) forming residues; other site 246196018428 trimer interface [polypeptide binding]; other site 246196018429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196018430 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196018431 putative substrate translocation pore; other site 246196018432 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 246196018433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018434 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 246196018435 dimerization interface [polypeptide binding]; other site 246196018436 substrate binding pocket [chemical binding]; other site 246196018437 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196018438 enoyl-CoA hydratase; Provisional; Region: PRK05862 246196018439 substrate binding site [chemical binding]; other site 246196018440 oxyanion hole (OAH) forming residues; other site 246196018441 trimer interface [polypeptide binding]; other site 246196018442 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196018443 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196018444 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 246196018445 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 246196018446 nucleophilic elbow; other site 246196018447 catalytic triad; other site 246196018448 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196018449 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196018450 RibD C-terminal domain; Region: RibD_C; cl17279 246196018451 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246196018452 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 246196018453 substrate binding site [chemical binding]; other site 246196018454 dimer interface [polypeptide binding]; other site 246196018455 triosephosphate isomerase; Provisional; Region: PRK14565 246196018456 catalytic triad [active] 246196018457 ribose 5-phosphate isomerase; Region: RPI_actino; TIGR02133 246196018458 dihydroxyacetone kinase; Provisional; Region: PRK14479 246196018459 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 246196018460 DAK2 domain; Region: Dak2; pfam02734 246196018461 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018463 DNA-binding site [nucleotide binding]; DNA binding site 246196018464 FCD domain; Region: FCD; pfam07729 246196018465 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196018466 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246196018467 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196018468 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196018469 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 246196018470 fructuronate transporter; Provisional; Region: PRK10034; cl15264 246196018471 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 246196018472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196018473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196018474 sequence-specific DNA binding site [nucleotide binding]; other site 246196018475 salt bridge; other site 246196018476 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196018477 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196018478 substrate binding site [chemical binding]; other site 246196018479 oxyanion hole (OAH) forming residues; other site 246196018480 trimer interface [polypeptide binding]; other site 246196018481 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196018482 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 246196018483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196018484 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246196018485 active site 246196018486 catalytic tetrad [active] 246196018487 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 246196018488 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196018489 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196018490 DNA binding site [nucleotide binding] 246196018491 domain linker motif; other site 246196018492 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196018493 dimerization interface [polypeptide binding]; other site 246196018494 ligand binding site [chemical binding]; other site 246196018495 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 246196018496 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 246196018497 active site 246196018498 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246196018499 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246196018500 substrate binding site [chemical binding]; other site 246196018501 ATP binding site [chemical binding]; other site 246196018502 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196018503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196018504 Walker A/P-loop; other site 246196018505 ATP binding site [chemical binding]; other site 246196018506 Q-loop/lid; other site 246196018507 ABC transporter signature motif; other site 246196018508 Walker B; other site 246196018509 D-loop; other site 246196018510 H-loop/switch region; other site 246196018511 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196018512 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196018513 TM-ABC transporter signature motif; other site 246196018514 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196018515 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 246196018516 ligand binding site [chemical binding]; other site 246196018517 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196018518 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196018519 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246196018520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196018521 ABC transporter signature motif; other site 246196018522 Walker B; other site 246196018523 D-loop; other site 246196018524 H-loop/switch region; other site 246196018525 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 246196018526 AAA domain; Region: AAA_21; pfam13304 246196018527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018528 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196018529 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 246196018530 Walker A motif; other site 246196018531 ATP binding site [chemical binding]; other site 246196018532 Walker B motif; other site 246196018533 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 246196018534 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246196018535 metal ion-dependent adhesion site (MIDAS); other site 246196018536 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 246196018537 potential frameshift: common BLAST hit: gi|315443430|ref|YP_004076309.1| sugar phosphate permease 246196018538 proline/glycine betaine transporter; Provisional; Region: PRK10642 246196018539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196018540 putative substrate translocation pore; other site 246196018541 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196018542 MarR family; Region: MarR; pfam01047 246196018543 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 246196018544 active site 246196018545 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246196018546 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 246196018547 putative [4Fe-4S] binding site [ion binding]; other site 246196018548 putative molybdopterin cofactor binding site [chemical binding]; other site 246196018549 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 246196018550 molybdopterin cofactor binding site; other site 246196018551 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 246196018552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196018553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196018554 DNA binding residues [nucleotide binding] 246196018555 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196018556 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246196018557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196018558 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246196018559 ATP binding site [chemical binding]; other site 246196018560 substrate binding site [chemical binding]; other site 246196018561 Survival protein SurE; Region: SurE; cl00448 246196018562 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 246196018563 short chain dehydrogenase; Provisional; Region: PRK06500 246196018564 classical (c) SDRs; Region: SDR_c; cd05233 246196018565 NAD(P) binding site [chemical binding]; other site 246196018566 active site 246196018567 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196018568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196018569 putative DNA binding site [nucleotide binding]; other site 246196018570 putative Zn2+ binding site [ion binding]; other site 246196018571 CAAX protease self-immunity; Region: Abi; pfam02517 246196018572 L-lactate permease; Region: Lactate_perm; cl00701 246196018573 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 246196018574 AAA ATPase domain; Region: AAA_16; pfam13191 246196018575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196018576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196018577 DNA binding residues [nucleotide binding] 246196018578 dimerization interface [polypeptide binding]; other site 246196018579 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196018580 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196018581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018582 TIGR03086 family protein; Region: TIGR03086 246196018583 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196018584 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196018585 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196018586 NAD(P) binding site [chemical binding]; other site 246196018587 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196018588 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 246196018589 putative NAD(P) binding site [chemical binding]; other site 246196018590 putative substrate binding site [chemical binding]; other site 246196018591 catalytic Zn binding site [ion binding]; other site 246196018592 structural Zn binding site [ion binding]; other site 246196018593 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 246196018594 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246196018595 putative di-iron ligands [ion binding]; other site 246196018596 Glutaminase; Region: Glutaminase; cl00907 246196018597 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196018598 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 246196018599 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196018600 catalytic loop [active] 246196018601 iron binding site [ion binding]; other site 246196018602 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018603 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 246196018604 haloalkane dehalogenase; Provisional; Region: PRK03592 246196018605 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 246196018606 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196018607 conserved cys residue [active] 246196018608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196018609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196018610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018611 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196018612 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 246196018613 putative dimerization interface [polypeptide binding]; other site 246196018614 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 246196018615 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196018616 inhibitor-cofactor binding pocket; inhibition site 246196018617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196018618 catalytic residue [active] 246196018619 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196018620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196018621 NAD(P) binding site [chemical binding]; other site 246196018622 active site 246196018623 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 246196018624 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 246196018625 DctM-like transporters; Region: DctM; pfam06808 246196018626 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 246196018627 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 246196018628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196018629 NAD(P) binding site [chemical binding]; other site 246196018630 active site 246196018631 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196018632 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196018633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018634 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 246196018635 putative dimerization interface [polypeptide binding]; other site 246196018636 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018637 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196018638 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 246196018639 substrate binding site [chemical binding]; other site 246196018640 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 246196018641 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 246196018642 substrate binding site [chemical binding]; other site 246196018643 3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065 246196018644 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 246196018645 substrate binding site [chemical binding]; other site 246196018646 ligand binding site [chemical binding]; other site 246196018647 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 246196018648 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196018649 tetramer interface [polypeptide binding]; other site 246196018650 active site 246196018651 Mg2+/Mn2+ binding site [ion binding]; other site 246196018652 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 246196018653 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196018654 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196018655 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196018656 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196018657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018658 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196018659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196018660 NAD(P) binding site [chemical binding]; other site 246196018661 active site 246196018662 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 246196018663 Cupin domain; Region: Cupin_2; pfam07883 246196018664 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 246196018665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018666 aldolase II superfamily protein; Provisional; Region: PRK07044 246196018667 intersubunit interface [polypeptide binding]; other site 246196018668 active site 246196018669 Zn2+ binding site [ion binding]; other site 246196018670 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196018671 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196018672 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196018673 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 246196018674 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196018675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196018676 dimer interface [polypeptide binding]; other site 246196018677 conserved gate region; other site 246196018678 putative PBP binding loops; other site 246196018679 ABC-ATPase subunit interface; other site 246196018680 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 246196018681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196018682 dimer interface [polypeptide binding]; other site 246196018683 conserved gate region; other site 246196018684 putative PBP binding loops; other site 246196018685 ABC-ATPase subunit interface; other site 246196018686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196018687 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 246196018688 Walker A/P-loop; other site 246196018689 ATP binding site [chemical binding]; other site 246196018690 Q-loop/lid; other site 246196018691 ABC transporter signature motif; other site 246196018692 Walker B; other site 246196018693 D-loop; other site 246196018694 H-loop/switch region; other site 246196018695 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196018696 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196018697 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 246196018698 Walker A/P-loop; other site 246196018699 ATP binding site [chemical binding]; other site 246196018700 Q-loop/lid; other site 246196018701 ABC transporter signature motif; other site 246196018702 Walker B; other site 246196018703 D-loop; other site 246196018704 H-loop/switch region; other site 246196018705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196018706 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196018707 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196018708 Creatinine amidohydrolase; Region: Creatininase; pfam02633 246196018709 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 246196018710 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 246196018711 metal binding site [ion binding]; metal-binding site 246196018712 substrate binding pocket [chemical binding]; other site 246196018713 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246196018714 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196018715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196018716 oxyanion hole (OAH) forming residues; other site 246196018717 trimer interface [polypeptide binding]; other site 246196018718 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196018719 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 246196018720 NAD(P) binding site [chemical binding]; other site 246196018721 catalytic residues [active] 246196018722 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246196018723 homotrimer interaction site [polypeptide binding]; other site 246196018724 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246196018725 homotrimer interaction site [polypeptide binding]; other site 246196018726 putative active site [active] 246196018727 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246196018728 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246196018729 Walker A/P-loop; other site 246196018730 ATP binding site [chemical binding]; other site 246196018731 Q-loop/lid; other site 246196018732 ABC transporter signature motif; other site 246196018733 Walker B; other site 246196018734 D-loop; other site 246196018735 H-loop/switch region; other site 246196018736 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196018737 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246196018738 Walker A/P-loop; other site 246196018739 ATP binding site [chemical binding]; other site 246196018740 Q-loop/lid; other site 246196018741 ABC transporter signature motif; other site 246196018742 Walker B; other site 246196018743 D-loop; other site 246196018744 H-loop/switch region; other site 246196018745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196018746 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246196018747 TM-ABC transporter signature motif; other site 246196018748 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246196018749 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246196018750 TM-ABC transporter signature motif; other site 246196018751 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 246196018752 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 246196018753 ligand binding site [chemical binding]; other site 246196018754 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018756 DNA-binding site [nucleotide binding]; DNA binding site 246196018757 FCD domain; Region: FCD; pfam07729 246196018758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196018759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196018761 dimerization interface [polypeptide binding]; other site 246196018762 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 246196018763 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 246196018764 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 246196018765 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196018766 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196018767 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246196018768 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196018769 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196018770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196018771 active site 246196018772 putative transposase OrfB; Reviewed; Region: PHA02517 246196018773 Integrase core domain; Region: rve; pfam00665 246196018774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196018775 Transposase; Region: HTH_Tnp_1; cl17663 246196018776 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 246196018777 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 246196018778 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246196018779 Walker A motif; other site 246196018780 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 246196018781 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 246196018782 Walker A motif; other site 246196018783 ATP binding site [chemical binding]; other site 246196018784 Walker B motif; other site 246196018785 DNA binding loops [nucleotide binding] 246196018786 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246196018787 protein-splicing catalytic site; other site 246196018788 thioester formation/cholesterol transfer; other site 246196018789 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 246196018790 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246196018791 protein-splicing catalytic site; other site 246196018792 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246196018793 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 246196018794 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 246196018795 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 246196018796 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 246196018797 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 246196018798 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 246196018799 dimer interface [polypeptide binding]; other site 246196018800 ssDNA binding site [nucleotide binding]; other site 246196018801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246196018802 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 246196018803 Predicted integral membrane protein [Function unknown]; Region: COG5650 246196018804 Transglycosylase; Region: Transgly; pfam00912 246196018805 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 246196018806 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196018807 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196018808 Predicted transcriptional regulators [Transcription]; Region: COG1695 246196018809 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 246196018810 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 246196018811 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 246196018812 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018813 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196018814 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 246196018815 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196018816 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246196018817 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018819 DNA-binding site [nucleotide binding]; DNA binding site 246196018820 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196018821 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196018822 substrate binding pocket [chemical binding]; other site 246196018823 membrane-bound complex binding site; other site 246196018824 hinge residues; other site 246196018825 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246196018826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196018827 dimer interface [polypeptide binding]; other site 246196018828 conserved gate region; other site 246196018829 putative PBP binding loops; other site 246196018830 ABC-ATPase subunit interface; other site 246196018831 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196018832 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196018833 Walker A/P-loop; other site 246196018834 ATP binding site [chemical binding]; other site 246196018835 Q-loop/lid; other site 246196018836 ABC transporter signature motif; other site 246196018837 Walker B; other site 246196018838 D-loop; other site 246196018839 H-loop/switch region; other site 246196018840 MarR family; Region: MarR; pfam01047 246196018841 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 246196018842 short chain dehydrogenase; Provisional; Region: PRK08219 246196018843 classical (c) SDRs; Region: SDR_c; cd05233 246196018844 NAD(P) binding site [chemical binding]; other site 246196018845 active site 246196018846 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 246196018847 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 246196018848 HIGH motif; other site 246196018849 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246196018850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246196018851 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246196018852 active site 246196018853 KMSKS motif; other site 246196018854 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 246196018855 tRNA binding surface [nucleotide binding]; other site 246196018856 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 246196018857 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 246196018858 hypothetical protein; Validated; Region: PRK00228 246196018859 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196018860 TIGR03084 family protein; Region: TIGR03084 246196018861 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196018862 Wyosine base formation; Region: Wyosine_form; pfam08608 246196018863 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 246196018864 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 246196018865 active site 246196018866 NTP binding site [chemical binding]; other site 246196018867 metal binding triad [ion binding]; metal-binding site 246196018868 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 246196018869 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196018870 Zn2+ binding site [ion binding]; other site 246196018871 Mg2+ binding site [ion binding]; other site 246196018872 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 246196018873 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 246196018874 active site 246196018875 Ap6A binding site [chemical binding]; other site 246196018876 nudix motif; other site 246196018877 metal binding site [ion binding]; metal-binding site 246196018878 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 246196018879 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 246196018880 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196018881 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 246196018882 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196018883 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196018884 DNA binding residues [nucleotide binding] 246196018885 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 246196018886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246196018887 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196018888 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246196018889 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246196018890 catalytic residues [active] 246196018891 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 246196018892 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246196018893 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246196018894 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246196018895 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246196018896 active site 246196018897 metal binding site [ion binding]; metal-binding site 246196018898 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 246196018899 ParB-like nuclease domain; Region: ParBc; pfam02195 246196018900 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246196018901 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196018902 Magnesium ion binding site [ion binding]; other site 246196018903 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 246196018904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196018905 S-adenosylmethionine binding site [chemical binding]; other site 246196018906 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 246196018907 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 246196018908 G-X-X-G motif; other site 246196018909 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 246196018910 RxxxH motif; other site 246196018911 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 246196018912 Ribonuclease P; Region: Ribonuclease_P; cl00457 246196018913 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399