-- dump date 20140619_153732 -- class Genbank::misc_feature -- table misc_feature_note -- id note 246196000001 DNA polymerase III subunit beta; Validated; Region: PRK07761 246196000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 246196000003 putative DNA binding surface [nucleotide binding]; other site 246196000004 dimer interface [polypeptide binding]; other site 246196000005 beta-clamp/clamp loader binding surface; other site 246196000006 beta-clamp/translesion DNA polymerase binding surface; other site 246196000007 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246196000008 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196000009 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 246196000010 recF protein; Region: recf; TIGR00611 246196000011 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 246196000012 Walker A/P-loop; other site 246196000013 ATP binding site [chemical binding]; other site 246196000014 Q-loop/lid; other site 246196000015 ABC transporter signature motif; other site 246196000016 Walker B; other site 246196000017 D-loop; other site 246196000018 H-loop/switch region; other site 246196000019 hypothetical protein; Provisional; Region: PRK03195 246196000020 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 246196000021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196000022 ATP binding site [chemical binding]; other site 246196000023 Mg2+ binding site [ion binding]; other site 246196000024 G-X-G motif; other site 246196000025 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 246196000026 anchoring element; other site 246196000027 dimer interface [polypeptide binding]; other site 246196000028 ATP binding site [chemical binding]; other site 246196000029 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 246196000030 active site 246196000031 metal binding site [ion binding]; metal-binding site 246196000032 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246196000033 DNA gyrase subunit A; Validated; Region: PRK05560 246196000034 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 246196000035 CAP-like domain; other site 246196000036 active site 246196000037 primary dimer interface [polypeptide binding]; other site 246196000038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196000044 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 246196000045 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246196000046 FAD binding pocket [chemical binding]; other site 246196000047 FAD binding motif [chemical binding]; other site 246196000048 phosphate binding motif [ion binding]; other site 246196000049 NAD binding pocket [chemical binding]; other site 246196000050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246196000051 ABC-ATPase subunit interface; other site 246196000052 dimer interface [polypeptide binding]; other site 246196000053 putative PBP binding regions; other site 246196000054 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196000055 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246196000056 Walker A/P-loop; other site 246196000057 ATP binding site [chemical binding]; other site 246196000058 Q-loop/lid; other site 246196000059 ABC transporter signature motif; other site 246196000060 Walker B; other site 246196000061 D-loop; other site 246196000062 H-loop/switch region; other site 246196000063 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 246196000064 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 246196000065 active site 246196000066 substrate binding site [chemical binding]; other site 246196000067 cosubstrate binding site; other site 246196000068 catalytic site [active] 246196000069 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 246196000070 MbtH-like protein; Region: MbtH; cl01279 246196000071 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196000072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196000073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000074 Walker A/P-loop; other site 246196000075 ATP binding site [chemical binding]; other site 246196000076 Q-loop/lid; other site 246196000077 ABC transporter signature motif; other site 246196000078 Walker B; other site 246196000079 D-loop; other site 246196000080 H-loop/switch region; other site 246196000081 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196000082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196000083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000084 Walker A/P-loop; other site 246196000085 ATP binding site [chemical binding]; other site 246196000086 Q-loop/lid; other site 246196000087 ABC transporter signature motif; other site 246196000088 Walker B; other site 246196000089 D-loop; other site 246196000090 H-loop/switch region; other site 246196000091 peptide synthase; Provisional; Region: PRK12316 246196000092 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000093 acyl-activating enzyme (AAE) consensus motif; other site 246196000094 AMP binding site [chemical binding]; other site 246196000095 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000096 Condensation domain; Region: Condensation; cl19241 246196000097 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196000098 Condensation domain; Region: Condensation; cl19241 246196000099 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000100 acyl-activating enzyme (AAE) consensus motif; other site 246196000101 AMP binding site [chemical binding]; other site 246196000102 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000103 Condensation domain; Region: Condensation; cl19241 246196000104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000105 acyl-activating enzyme (AAE) consensus motif; other site 246196000106 AMP binding site [chemical binding]; other site 246196000107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000108 Condensation domain; Region: Condensation; cl19241 246196000109 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196000110 Condensation domain; Region: Condensation; pfam00668 246196000111 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000112 acyl-activating enzyme (AAE) consensus motif; other site 246196000113 AMP binding site [chemical binding]; other site 246196000114 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000115 Condensation domain; Region: Condensation; cl19241 246196000116 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196000117 Condensation domain; Region: Condensation; cl19241 246196000118 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196000119 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000120 acyl-activating enzyme (AAE) consensus motif; other site 246196000121 AMP binding site [chemical binding]; other site 246196000122 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000123 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 246196000124 Condensation domain; Region: Condensation; pfam00668 246196000125 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196000126 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196000127 acyl-activating enzyme (AAE) consensus motif; other site 246196000128 AMP binding site [chemical binding]; other site 246196000129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196000130 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 246196000131 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 246196000132 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 246196000133 siderophore binding site; other site 246196000134 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 246196000135 tetramerization interface [polypeptide binding]; other site 246196000136 active site 246196000137 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 246196000138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196000139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196000140 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 246196000141 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246196000142 active site 246196000143 Bacterial PH domain; Region: bPH_6; pfam10756 246196000144 putative septation inhibitor protein; Reviewed; Region: PRK00159 246196000145 Bacterial protein of unknown function (DUF881); Region: DUF881; cl19849 246196000146 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 246196000147 Glutamine amidotransferase class-I; Region: GATase; pfam00117 246196000148 glutamine binding [chemical binding]; other site 246196000149 catalytic triad [active] 246196000150 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196000151 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196000152 active site 246196000153 ATP binding site [chemical binding]; other site 246196000154 substrate binding site [chemical binding]; other site 246196000155 activation loop (A-loop); other site 246196000156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 246196000157 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196000158 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196000159 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196000160 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196000161 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196000162 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196000163 active site 246196000164 ATP binding site [chemical binding]; other site 246196000165 substrate binding site [chemical binding]; other site 246196000166 activation loop (A-loop); other site 246196000167 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 246196000168 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196000169 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 246196000170 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246196000171 active site 246196000172 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196000173 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196000174 phosphopeptide binding site; other site 246196000175 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 246196000176 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196000177 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196000178 phosphopeptide binding site; other site 246196000179 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 246196000180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000182 WHG domain; Region: WHG; pfam13305 246196000183 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 246196000184 putative active site [active] 246196000185 metal binding site [ion binding]; metal-binding site 246196000186 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 246196000187 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 246196000188 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196000189 Pirin-related protein [General function prediction only]; Region: COG1741 246196000190 Pirin; Region: Pirin; pfam02678 246196000191 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 246196000192 DivIVA domain; Region: DivI1A_domain; TIGR03544 246196000193 DivIVA domain; Region: DivI1A_domain; TIGR03544 246196000194 Transcription factor WhiB; Region: Whib; pfam02467 246196000195 Helix-turn-helix domain; Region: HTH_31; pfam13560 246196000196 Winged helix-turn helix; Region: HTH_29; pfam13551 246196000197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196000198 putative DNA binding site [nucleotide binding]; other site 246196000199 dimerization interface [polypeptide binding]; other site 246196000200 putative Zn2+ binding site [ion binding]; other site 246196000201 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196000202 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 246196000203 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196000204 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196000205 EspG family; Region: ESX-1_EspG; pfam14011 246196000206 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 246196000207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196000208 Walker A motif; other site 246196000209 ATP binding site [chemical binding]; other site 246196000210 Walker B motif; other site 246196000211 arginine finger; other site 246196000212 Protein of unknown function (DUF690); Region: DUF690; cl04939 246196000213 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 246196000214 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196000215 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 246196000216 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196000217 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196000218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196000219 Walker A motif; other site 246196000220 ATP binding site [chemical binding]; other site 246196000221 PE family; Region: PE; pfam00934 246196000222 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 246196000223 PPE family; Region: PPE; pfam00823 246196000224 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 246196000225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 246196000226 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 246196000227 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196000228 P-loop; other site 246196000229 Magnesium ion binding site [ion binding]; other site 246196000230 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 246196000231 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 246196000232 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196000233 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196000234 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 246196000235 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 246196000236 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 246196000237 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 246196000238 active site 246196000239 catalytic residues [active] 246196000240 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 246196000241 dimerization domain swap beta strand [polypeptide binding]; other site 246196000242 regulatory protein interface [polypeptide binding]; other site 246196000243 active site 246196000244 regulatory phosphorylation site [posttranslational modification]; other site 246196000245 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 246196000246 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 246196000247 active site 246196000248 phosphorylation site [posttranslational modification] 246196000249 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 246196000250 active site 246196000251 P-loop; other site 246196000252 phosphorylation site [posttranslational modification] 246196000253 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 246196000254 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 246196000255 putative substrate binding site [chemical binding]; other site 246196000256 putative ATP binding site [chemical binding]; other site 246196000257 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196000258 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 246196000259 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196000260 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 246196000261 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 246196000262 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 246196000263 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246196000264 Pirin-related protein [General function prediction only]; Region: COG1741 246196000265 Pirin; Region: Pirin; pfam02678 246196000266 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 246196000267 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246196000268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000270 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 246196000271 LDH/MDH dimer interface [polypeptide binding]; other site 246196000272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000274 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196000275 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196000276 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196000277 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 246196000278 NAD binding site [chemical binding]; other site 246196000279 homodimer interface [polypeptide binding]; other site 246196000280 active site 246196000281 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196000282 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 246196000283 NAD(P) binding site [chemical binding]; other site 246196000284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196000285 S-adenosylmethionine binding site [chemical binding]; other site 246196000286 Protein of unknown function (DUF456); Region: DUF456; pfam04306 246196000287 YceI-like domain; Region: YceI; smart00867 246196000288 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 246196000289 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 246196000290 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 246196000291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196000293 active site 246196000294 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196000295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000296 putative substrate translocation pore; other site 246196000297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196000298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196000299 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 246196000300 putative dimerization interface [polypeptide binding]; other site 246196000301 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196000302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196000303 active site 246196000304 phosphorylation site [posttranslational modification] 246196000305 intermolecular recognition site; other site 246196000306 dimerization interface [polypeptide binding]; other site 246196000307 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196000308 DNA binding residues [nucleotide binding] 246196000309 dimerization interface [polypeptide binding]; other site 246196000310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196000311 Histidine kinase; Region: HisKA_3; pfam07730 246196000312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196000313 ATP binding site [chemical binding]; other site 246196000314 Mg2+ binding site [ion binding]; other site 246196000315 G-X-G motif; other site 246196000316 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 246196000317 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196000318 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000319 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196000320 active site 246196000321 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 246196000322 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 246196000323 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 246196000324 ligand binding site [chemical binding]; other site 246196000325 homodimer interface [polypeptide binding]; other site 246196000326 NAD(P) binding site [chemical binding]; other site 246196000327 trimer interface B [polypeptide binding]; other site 246196000328 trimer interface A [polypeptide binding]; other site 246196000329 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 246196000330 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 246196000331 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 246196000332 oligomer interface [polypeptide binding]; other site 246196000333 metal binding site [ion binding]; metal-binding site 246196000334 metal binding site [ion binding]; metal-binding site 246196000335 putative Cl binding site [ion binding]; other site 246196000336 aspartate ring; other site 246196000337 basic sphincter; other site 246196000338 hydrophobic gate; other site 246196000339 periplasmic entrance; other site 246196000340 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196000341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196000342 dimer interface [polypeptide binding]; other site 246196000343 conserved gate region; other site 246196000344 putative PBP binding loops; other site 246196000345 ABC-ATPase subunit interface; other site 246196000346 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196000347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196000348 substrate binding pocket [chemical binding]; other site 246196000349 membrane-bound complex binding site; other site 246196000350 hinge residues; other site 246196000351 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196000352 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196000353 Walker A/P-loop; other site 246196000354 ATP binding site [chemical binding]; other site 246196000355 Q-loop/lid; other site 246196000356 ABC transporter signature motif; other site 246196000357 Walker B; other site 246196000358 D-loop; other site 246196000359 H-loop/switch region; other site 246196000360 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 246196000361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196000362 active site 246196000363 motif I; other site 246196000364 motif II; other site 246196000365 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196000366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196000367 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196000368 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 246196000369 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196000370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000372 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 246196000373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196000374 NAD(P) binding site [chemical binding]; other site 246196000375 active site 246196000376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 246196000377 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 246196000378 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 246196000379 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196000380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000381 DNA-binding site [nucleotide binding]; DNA binding site 246196000382 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196000383 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 246196000384 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 246196000385 active site pocket [active] 246196000386 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 246196000387 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196000388 NAD(P) binding site [chemical binding]; other site 246196000389 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246196000390 active site 246196000391 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 246196000392 putative hydrophobic ligand binding site [chemical binding]; other site 246196000393 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196000394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000395 DNA-binding site [nucleotide binding]; DNA binding site 246196000396 FCD domain; Region: FCD; pfam07729 246196000397 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 246196000398 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196000399 acyl-activating enzyme (AAE) consensus motif; other site 246196000400 AMP binding site [chemical binding]; other site 246196000401 active site 246196000402 CoA binding site [chemical binding]; other site 246196000403 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196000404 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196000405 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000406 mce related protein; Region: MCE; pfam02470 246196000407 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196000408 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000409 mce related protein; Region: MCE; pfam02470 246196000410 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196000411 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000412 mce related protein; Region: MCE; pfam02470 246196000413 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196000414 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000415 mce related protein; Region: MCE; pfam02470 246196000416 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 246196000417 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000418 mce related protein; Region: MCE; pfam02470 246196000419 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196000420 mce related protein; Region: MCE; pfam02470 246196000421 RDD family; Region: RDD; pfam06271 246196000422 SnoaL-like domain; Region: SnoaL_4; cl17707 246196000423 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 246196000424 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196000425 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196000426 active site 246196000427 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 246196000428 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 246196000429 MOSC domain; Region: MOSC; pfam03473 246196000430 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246196000431 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246196000432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000434 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 246196000435 ThiC-associated domain; Region: ThiC-associated; pfam13667 246196000436 ThiC family; Region: ThiC; cl08031 246196000437 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 246196000438 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 246196000439 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 246196000440 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 246196000441 ligand binding site [chemical binding]; other site 246196000442 homodimer interface [polypeptide binding]; other site 246196000443 NAD(P) binding site [chemical binding]; other site 246196000444 trimer interface B [polypeptide binding]; other site 246196000445 trimer interface A [polypeptide binding]; other site 246196000446 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 246196000447 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 246196000448 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 246196000449 pyruvate kinase; Provisional; Region: PRK06247 246196000450 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 246196000451 domain interfaces; other site 246196000452 active site 246196000453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196000454 PAS domain; Region: PAS_9; pfam13426 246196000455 putative active site [active] 246196000456 heme pocket [chemical binding]; other site 246196000457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196000458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196000459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196000460 dimerization interface [polypeptide binding]; other site 246196000461 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 246196000462 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196000463 PYR/PP interface [polypeptide binding]; other site 246196000464 dimer interface [polypeptide binding]; other site 246196000465 TPP binding site [chemical binding]; other site 246196000466 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196000467 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 246196000468 TPP-binding site; other site 246196000469 dimer interface [polypeptide binding]; other site 246196000470 formyl-coenzyme A transferase; Provisional; Region: PRK05398 246196000471 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 246196000472 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 246196000473 putative dimer interface [polypeptide binding]; other site 246196000474 [2Fe-2S] cluster binding site [ion binding]; other site 246196000475 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 246196000476 putative dimer interface [polypeptide binding]; other site 246196000477 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 246196000478 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 246196000479 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 246196000480 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196000481 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 246196000482 catalytic loop [active] 246196000483 iron binding site [ion binding]; other site 246196000484 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 246196000485 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 246196000486 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 246196000487 [4Fe-4S] binding site [ion binding]; other site 246196000488 molybdopterin cofactor binding site; other site 246196000489 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 246196000490 molybdopterin cofactor binding site; other site 246196000491 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 246196000492 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 246196000493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000494 putative substrate translocation pore; other site 246196000495 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 246196000496 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196000497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000498 DNA-binding site [nucleotide binding]; DNA binding site 246196000499 FCD domain; Region: FCD; pfam07729 246196000500 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196000501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000502 putative substrate translocation pore; other site 246196000503 formyl-coenzyme A transferase; Provisional; Region: PRK05398 246196000504 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196000505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000506 putative substrate translocation pore; other site 246196000507 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 246196000508 putative active site [active] 246196000509 Zn binding site [ion binding]; other site 246196000510 Domain of unknown function (DUF202); Region: DUF202; cl09954 246196000511 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196000512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196000513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196000514 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196000515 substrate binding pocket [chemical binding]; other site 246196000516 membrane-bound complex binding site; other site 246196000517 hinge residues; other site 246196000518 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196000519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196000520 dimer interface [polypeptide binding]; other site 246196000521 conserved gate region; other site 246196000522 putative PBP binding loops; other site 246196000523 ABC-ATPase subunit interface; other site 246196000524 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196000525 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196000526 Walker A/P-loop; other site 246196000527 ATP binding site [chemical binding]; other site 246196000528 Q-loop/lid; other site 246196000529 ABC transporter signature motif; other site 246196000530 Walker B; other site 246196000531 D-loop; other site 246196000532 H-loop/switch region; other site 246196000533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196000534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000535 DNA-binding site [nucleotide binding]; DNA binding site 246196000536 FCD domain; Region: FCD; pfam07729 246196000537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000539 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 246196000540 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 246196000541 substrate binding pocket [chemical binding]; other site 246196000542 active site 246196000543 iron coordination sites [ion binding]; other site 246196000544 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196000545 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196000546 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 246196000547 Transport protein; Region: actII; TIGR00833 246196000548 MMPL family; Region: MMPL; pfam03176 246196000549 MMPL family; Region: MMPL; pfam03176 246196000550 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196000551 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196000552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196000553 putative acetyltransferase; Provisional; Region: PRK03624 246196000554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196000555 Coenzyme A binding pocket [chemical binding]; other site 246196000556 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 246196000557 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 246196000558 Na binding site [ion binding]; other site 246196000559 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246196000560 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 246196000561 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 246196000562 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 246196000563 putative active site [active] 246196000564 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 246196000565 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 246196000566 putative active site [active] 246196000567 Cutinase; Region: Cutinase; pfam01083 246196000568 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196000569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196000570 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196000571 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196000572 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 246196000573 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246196000574 nudix motif; other site 246196000575 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000576 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196000577 active site 246196000578 PE-PPE domain; Region: PE-PPE; pfam08237 246196000579 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 246196000580 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 246196000581 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196000582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196000583 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196000584 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196000585 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 246196000586 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 246196000587 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196000588 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196000589 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196000590 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 246196000591 active site 246196000592 barstar interaction site; other site 246196000593 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 246196000594 putative RNAase interaction site [polypeptide binding]; other site 246196000595 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 246196000596 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 246196000597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000598 Walker A/P-loop; other site 246196000599 ATP binding site [chemical binding]; other site 246196000600 Q-loop/lid; other site 246196000601 ABC transporter signature motif; other site 246196000602 Walker B; other site 246196000603 D-loop; other site 246196000604 H-loop/switch region; other site 246196000605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196000606 Walker A/P-loop; other site 246196000607 ATP binding site [chemical binding]; other site 246196000608 Q-loop/lid; other site 246196000609 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 246196000610 ABC transporter signature motif; other site 246196000611 Walker B; other site 246196000612 D-loop; other site 246196000613 H-loop/switch region; other site 246196000614 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 246196000615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196000616 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196000617 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 246196000618 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 246196000619 Pirin-related protein [General function prediction only]; Region: COG1741 246196000620 Pirin; Region: Pirin; pfam02678 246196000621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196000622 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196000623 NAD(P) binding site [chemical binding]; other site 246196000624 active site 246196000625 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 246196000626 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196000627 NAD binding site [chemical binding]; other site 246196000628 catalytic Zn binding site [ion binding]; other site 246196000629 substrate binding site [chemical binding]; other site 246196000630 structural Zn binding site [ion binding]; other site 246196000631 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 246196000632 dimer interface [polypeptide binding]; other site 246196000633 RNA polymerase factor sigma-70; Validated; Region: PRK08241 246196000634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196000635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196000636 DNA binding residues [nucleotide binding] 246196000637 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196000638 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246196000639 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196000640 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196000641 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 246196000642 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 246196000643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196000644 S-adenosylmethionine binding site [chemical binding]; other site 246196000645 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196000646 MMPL family; Region: MMPL; pfam03176 246196000647 Snf7; Region: Snf7; cl19390 246196000648 MMPL family; Region: MMPL; pfam03176 246196000649 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196000650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000652 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 246196000653 Double zinc ribbon; Region: DZR; pfam12773 246196000654 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196000655 cyclase homology domain; Region: CHD; cd07302 246196000656 nucleotidyl binding site; other site 246196000657 metal binding site [ion binding]; metal-binding site 246196000658 dimer interface [polypeptide binding]; other site 246196000659 Predicted ATPase [General function prediction only]; Region: COG3899 246196000660 AAA ATPase domain; Region: AAA_16; pfam13191 246196000661 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 246196000662 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 246196000663 putative homodimer interface [polypeptide binding]; other site 246196000664 putative homotetramer interface [polypeptide binding]; other site 246196000665 putative allosteric switch controlling residues; other site 246196000666 putative metal binding site [ion binding]; other site 246196000667 putative homodimer-homodimer interface [polypeptide binding]; other site 246196000668 Domain of unknown function DUF77; Region: DUF77; pfam01910 246196000669 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196000670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000671 putative substrate translocation pore; other site 246196000672 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 246196000673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196000674 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196000675 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 246196000676 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 246196000677 active site 246196000678 Zn binding site [ion binding]; other site 246196000679 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196000680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 246196000681 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 246196000682 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246196000683 homodimer interface [polypeptide binding]; other site 246196000684 substrate-cofactor binding pocket; other site 246196000685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196000686 catalytic residue [active] 246196000687 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 246196000688 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196000689 MMPL family; Region: MMPL; cl14618 246196000690 MMPL family; Region: MMPL; cl14618 246196000691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196000692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196000693 active site 246196000694 phosphorylation site [posttranslational modification] 246196000695 intermolecular recognition site; other site 246196000696 dimerization interface [polypeptide binding]; other site 246196000697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196000698 DNA binding site [nucleotide binding] 246196000699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196000700 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196000701 dimerization interface [polypeptide binding]; other site 246196000702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196000703 phosphorylation site [posttranslational modification] 246196000704 dimer interface [polypeptide binding]; other site 246196000705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196000706 ATP binding site [chemical binding]; other site 246196000707 Mg2+ binding site [ion binding]; other site 246196000708 G-X-G motif; other site 246196000709 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 246196000710 Peptidase family M23; Region: Peptidase_M23; pfam01551 246196000711 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246196000712 Predicted integral membrane protein [Function unknown]; Region: COG0392 246196000713 Domain of unknown function DUF20; Region: UPF0118; pfam01594 246196000714 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196000715 MMPL family; Region: MMPL; cl14618 246196000716 MMPL family; Region: MMPL; cl14618 246196000717 LabA_like proteins; Region: LabA_like; cd06167 246196000718 putative metal binding site [ion binding]; other site 246196000719 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 246196000720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196000721 S-adenosylmethionine binding site [chemical binding]; other site 246196000722 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246196000723 Switch II region; other site 246196000724 G4 box; other site 246196000725 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 246196000726 active site 246196000727 substrate-binding site [chemical binding]; other site 246196000728 metal-binding site [ion binding] 246196000729 GTP binding site [chemical binding]; other site 246196000730 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 246196000731 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196000732 acyl-activating enzyme (AAE) consensus motif; other site 246196000733 putative AMP binding site [chemical binding]; other site 246196000734 putative active site [active] 246196000735 putative CoA binding site [chemical binding]; other site 246196000736 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196000737 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196000738 substrate binding site [chemical binding]; other site 246196000739 oxyanion hole (OAH) forming residues; other site 246196000740 trimer interface [polypeptide binding]; other site 246196000741 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196000742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196000743 NAD(P) binding site [chemical binding]; other site 246196000744 active site 246196000745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196000746 salt bridge; other site 246196000747 non-specific DNA binding site [nucleotide binding]; other site 246196000748 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196000749 sequence-specific DNA binding site [nucleotide binding]; other site 246196000750 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 246196000751 putative active site [active] 246196000752 putative catalytic site [active] 246196000753 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196000754 active site 2 [active] 246196000755 active site 1 [active] 246196000756 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196000757 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196000758 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196000759 active site 246196000760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196000761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196000762 putative substrate translocation pore; other site 246196000763 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 246196000764 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196000765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196000766 catalytic residue [active] 246196000767 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 246196000768 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 246196000769 Fe-S cluster binding site [ion binding]; other site 246196000770 active site 246196000771 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196000772 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196000773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196000774 DNA-binding site [nucleotide binding]; DNA binding site 246196000775 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196000776 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 246196000777 short chain dehydrogenase; Provisional; Region: PRK12829 246196000778 classical (c) SDRs; Region: SDR_c; cd05233 246196000779 NAD(P) binding site [chemical binding]; other site 246196000780 active site 246196000781 Phosphotransferase enzyme family; Region: APH; pfam01636 246196000782 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 246196000783 active site 246196000784 ATP binding site [chemical binding]; other site 246196000785 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 246196000786 Hexamer interface [polypeptide binding]; other site 246196000787 Hexagonal pore residue; other site 246196000788 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 246196000789 putative hexamer interface [polypeptide binding]; other site 246196000790 putative hexagonal pore; other site 246196000791 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 246196000792 Hexamer interface [polypeptide binding]; other site 246196000793 Hexagonal pore residue; other site 246196000794 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 246196000795 Hexamer/Pentamer interface [polypeptide binding]; other site 246196000796 central pore; other site 246196000797 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 246196000798 putative hexamer interface [polypeptide binding]; other site 246196000799 putative hexagonal pore; other site 246196000800 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 246196000801 putative hexamer interface [polypeptide binding]; other site 246196000802 putative hexagonal pore; other site 246196000803 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196000804 NAD(P) binding site [chemical binding]; other site 246196000805 catalytic residues [active] 246196000806 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196000807 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196000808 inhibitor-cofactor binding pocket; inhibition site 246196000809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196000810 catalytic residue [active] 246196000811 Amino acid permease; Region: AA_permease; pfam00324 246196000812 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196000813 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196000814 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196000815 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246196000816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196000817 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196000818 EthD domain; Region: EthD; cl17553 246196000819 short chain dehydrogenase; Provisional; Region: PRK06523 246196000820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196000821 NAD(P) binding site [chemical binding]; other site 246196000822 active site 246196000823 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 246196000824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196000825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196000826 transcriptional regulator protein; Region: phnR; TIGR03337 246196000827 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196000828 DNA-binding site [nucleotide binding]; DNA binding site 246196000829 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 246196000830 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 246196000831 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 246196000832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196000833 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 246196000834 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196000835 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196000836 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196000837 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246196000838 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 246196000839 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 246196000840 substrate binding pocket [chemical binding]; other site 246196000841 active site 246196000842 iron coordination sites [ion binding]; other site 246196000843 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196000844 [2Fe-2S] cluster binding site [ion binding]; other site 246196000845 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 246196000846 alpha subunit interface [polypeptide binding]; other site 246196000847 active site 246196000848 substrate binding site [chemical binding]; other site 246196000849 Fe binding site [ion binding]; other site 246196000850 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196000851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196000852 NAD(P) binding site [chemical binding]; other site 246196000853 active site 246196000854 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 246196000855 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 246196000856 FAD binding pocket [chemical binding]; other site 246196000857 FAD binding motif [chemical binding]; other site 246196000858 phosphate binding motif [ion binding]; other site 246196000859 beta-alpha-beta structure motif; other site 246196000860 NAD(p) ribose binding residues [chemical binding]; other site 246196000861 NAD binding pocket [chemical binding]; other site 246196000862 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 246196000863 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196000864 catalytic loop [active] 246196000865 iron binding site [ion binding]; other site 246196000866 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196000867 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196000868 putative Zn2+ binding site [ion binding]; other site 246196000869 putative DNA binding site [nucleotide binding]; other site 246196000870 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196000871 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196000872 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 246196000873 active site 246196000874 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196000875 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196000876 [2Fe-2S] cluster binding site [ion binding]; other site 246196000877 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 246196000878 alpha subunit interface [polypeptide binding]; other site 246196000879 active site 246196000880 substrate binding site [chemical binding]; other site 246196000881 Fe binding site [ion binding]; other site 246196000882 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196000883 FAD binding domain; Region: FAD_binding_4; pfam01565 246196000884 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246196000885 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 246196000886 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 246196000887 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196000888 putative NAD(P) binding site [chemical binding]; other site 246196000889 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 246196000890 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196000891 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196000892 acyl-CoA synthetase; Provisional; Region: PRK13382 246196000893 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196000894 acyl-activating enzyme (AAE) consensus motif; other site 246196000895 putative AMP binding site [chemical binding]; other site 246196000896 putative active site [active] 246196000897 putative CoA binding site [chemical binding]; other site 246196000898 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 246196000899 putative acyl-acceptor binding pocket; other site 246196000900 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 246196000901 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196000902 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246196000903 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 246196000904 NAD binding site [chemical binding]; other site 246196000905 catalytic residues [active] 246196000906 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196000907 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196000908 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 246196000909 active site 246196000910 intersubunit interface [polypeptide binding]; other site 246196000911 catalytic residue [active] 246196000912 phosphogluconate dehydratase; Validated; Region: PRK09054 246196000913 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 246196000914 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 246196000915 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 246196000916 putative DNA binding site [nucleotide binding]; other site 246196000917 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 246196000918 putative Zn2+ binding site [ion binding]; other site 246196000919 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196000920 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196000921 nucleotide binding site [chemical binding]; other site 246196000922 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 246196000923 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 246196000924 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196000925 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196000926 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 246196000927 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196000928 putative AMP binding site [chemical binding]; other site 246196000929 putative active site [active] 246196000930 acyl-activating enzyme (AAE) consensus motif; other site 246196000931 acyl-activating enzyme (AAE) consensus motif; other site 246196000932 putative CoA binding site [chemical binding]; other site 246196000933 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 246196000934 active site 246196000935 substrate binding pocket [chemical binding]; other site 246196000936 homodimer interaction site [polypeptide binding]; other site 246196000937 AAA ATPase domain; Region: AAA_16; pfam13191 246196000938 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196000939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196000940 DNA binding residues [nucleotide binding] 246196000941 dimerization interface [polypeptide binding]; other site 246196000942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000943 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196000944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196000945 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 246196000946 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 246196000947 acyl-CoA synthetase; Validated; Region: PRK06188 246196000948 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196000949 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196000950 acyl-activating enzyme (AAE) consensus motif; other site 246196000951 acyl-activating enzyme (AAE) consensus motif; other site 246196000952 putative AMP binding site [chemical binding]; other site 246196000953 putative active site [active] 246196000954 putative CoA binding site [chemical binding]; other site 246196000955 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196000956 NAD(P) binding site [chemical binding]; other site 246196000957 catalytic residues [active] 246196000958 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 246196000959 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196000960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196000961 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196000962 DNA binding residues [nucleotide binding] 246196000963 dimerization interface [polypeptide binding]; other site 246196000964 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246196000965 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196000966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196000967 DNA binding residues [nucleotide binding] 246196000968 dimerization interface [polypeptide binding]; other site 246196000969 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 246196000970 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196000971 FMN binding site [chemical binding]; other site 246196000972 substrate binding site [chemical binding]; other site 246196000973 putative catalytic residue [active] 246196000974 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 246196000975 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196000976 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 246196000977 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196000978 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196000979 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196000980 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196000981 carboxyltransferase (CT) interaction site; other site 246196000982 biotinylation site [posttranslational modification]; other site 246196000983 enoyl-CoA hydratase; Provisional; Region: PRK08252 246196000984 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196000985 substrate binding site [chemical binding]; other site 246196000986 oxyanion hole (OAH) forming residues; other site 246196000987 trimer interface [polypeptide binding]; other site 246196000988 TIGR03084 family protein; Region: TIGR03084 246196000989 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196000990 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 246196000991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196000992 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196000993 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196000994 active site 246196000995 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196000996 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196000997 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196000998 enoyl-CoA hydratase; Provisional; Region: PRK06688 246196000999 substrate binding site [chemical binding]; other site 246196001000 oxyanion hole (OAH) forming residues; other site 246196001001 trimer interface [polypeptide binding]; other site 246196001002 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196001003 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196001004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001006 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196001007 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196001008 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001009 mce related protein; Region: MCE; pfam02470 246196001010 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196001011 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196001012 mce related protein; Region: MCE; pfam02470 246196001013 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001014 mce related protein; Region: MCE; pfam02470 246196001015 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001016 mce related protein; Region: MCE; pfam02470 246196001017 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001018 mce related protein; Region: MCE; pfam02470 246196001019 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196001020 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196001021 mce related protein; Region: MCE; pfam02470 246196001022 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196001023 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 246196001024 GCN5-related N-acetyl-transferase; Region: Acetyltransf_CG; pfam14542 246196001025 Transmembrane secretion effector; Region: MFS_3; pfam05977 246196001026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001027 putative substrate translocation pore; other site 246196001028 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 246196001029 active site 246196001030 diiron metal binding site [ion binding]; other site 246196001031 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 246196001032 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 246196001033 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 246196001034 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 246196001035 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196001036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001038 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 246196001039 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 246196001040 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 246196001041 O-methyltransferase; Region: Methyltransf_2; pfam00891 246196001042 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 246196001043 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 246196001044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 246196001045 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 246196001046 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 246196001047 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196001048 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196001049 active site 2 [active] 246196001050 active site 1 [active] 246196001051 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 246196001052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001053 NAD(P) binding site [chemical binding]; other site 246196001054 active site 246196001055 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 246196001056 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196001057 dimer interface [polypeptide binding]; other site 246196001058 active site 246196001059 FAD binding domain; Region: FAD_binding_4; pfam01565 246196001060 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246196001061 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 246196001062 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196001063 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 246196001064 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246196001065 putative active site [active] 246196001066 catalytic site [active] 246196001067 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 246196001068 putative active site [active] 246196001069 catalytic site [active] 246196001070 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246196001071 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196001072 conserved cys residue [active] 246196001073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196001074 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 246196001075 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 246196001076 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 246196001077 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 246196001078 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 246196001079 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196001080 Transport protein; Region: actII; TIGR00833 246196001081 MMPL family; Region: MMPL; pfam03176 246196001082 MMPL family; Region: MMPL; pfam03176 246196001083 Transport protein; Region: actII; TIGR00833 246196001084 MMPL family; Region: MMPL; pfam03176 246196001085 MMPL family; Region: MMPL; pfam03176 246196001086 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 246196001087 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 246196001088 substrate binding site; other site 246196001089 tetramer interface; other site 246196001090 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196001091 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196001092 active site 246196001093 TDP-binding site; other site 246196001094 acceptor substrate-binding pocket; other site 246196001095 homodimer interface [polypeptide binding]; other site 246196001096 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196001097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001098 NAD(P) binding site [chemical binding]; other site 246196001099 active site 246196001100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196001101 S-adenosylmethionine binding site [chemical binding]; other site 246196001102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196001103 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196001104 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196001105 homodimer interface [polypeptide binding]; other site 246196001106 active site 246196001107 TDP-binding site; other site 246196001108 acceptor substrate-binding pocket; other site 246196001109 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196001110 Methyltransferase domain; Region: Methyltransf_24; pfam13578 246196001111 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196001112 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196001113 homodimer interface [polypeptide binding]; other site 246196001114 active site 246196001115 TDP-binding site; other site 246196001116 acceptor substrate-binding pocket; other site 246196001117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196001118 S-adenosylmethionine binding site [chemical binding]; other site 246196001119 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196001120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196001121 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196001122 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196001123 MbtH-like protein; Region: MbtH; pfam03621 246196001124 Condensation domain; Region: Condensation; cl19241 246196001125 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196001126 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246196001127 acyl-activating enzyme (AAE) consensus motif; other site 246196001128 AMP binding site [chemical binding]; other site 246196001129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196001130 Condensation domain; Region: Condensation; cl19241 246196001131 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196001132 Condensation domain; Region: Condensation; pfam00668 246196001133 acyltransferase PapA5; Provisional; Region: PRK09294 246196001134 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196001135 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196001136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196001137 acyl-activating enzyme (AAE) consensus motif; other site 246196001138 AMP binding site [chemical binding]; other site 246196001139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196001140 Condensation domain; Region: Condensation; cl19241 246196001141 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196001142 Condensation domain; Region: Condensation; cl19241 246196001143 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196001144 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196001145 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246196001146 acyl-activating enzyme (AAE) consensus motif; other site 246196001147 AMP binding site [chemical binding]; other site 246196001148 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196001149 Condensation domain; Region: Condensation; cl19241 246196001150 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196001151 Condensation domain; Region: Condensation; pfam00668 246196001152 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196001153 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196001154 acyl-activating enzyme (AAE) consensus motif; other site 246196001155 AMP binding site [chemical binding]; other site 246196001156 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196001157 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196001158 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246196001159 putative NAD(P) binding site [chemical binding]; other site 246196001160 active site 246196001161 putative substrate binding site [chemical binding]; other site 246196001162 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196001163 YCII-related domain; Region: YCII; cl00999 246196001164 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 246196001165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196001166 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196001167 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 246196001168 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 246196001169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196001170 active site 246196001171 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 246196001172 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196001173 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196001174 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246196001175 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196001176 active site 246196001177 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196001178 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 246196001179 short chain dehydrogenase; Region: adh_short; pfam00106 246196001180 NADP binding site [chemical binding]; other site 246196001181 active site 246196001182 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196001183 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246196001184 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196001185 active site 246196001186 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196001187 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 246196001188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001189 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 246196001190 Enoylreductase; Region: PKS_ER; smart00829 246196001191 NAD(P) binding site [chemical binding]; other site 246196001192 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246196001193 short chain dehydrogenase; Region: adh_short; pfam00106 246196001194 putative NADP binding site [chemical binding]; other site 246196001195 active site 246196001196 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196001197 Condensation domain; Region: Condensation; cl19241 246196001198 Transport protein; Region: actII; TIGR00833 246196001199 MMPL family; Region: MMPL; pfam03176 246196001200 MMPL family; Region: MMPL; pfam03176 246196001201 acyl-CoA synthetase; Validated; Region: PRK05850 246196001202 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196001203 acyl-activating enzyme (AAE) consensus motif; other site 246196001204 active site 246196001205 PE-PPE domain; Region: PE-PPE; pfam08237 246196001206 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196001207 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196001208 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196001209 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196001210 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 246196001211 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 246196001212 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196001213 catalytic loop [active] 246196001214 iron binding site [ion binding]; other site 246196001215 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 246196001216 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 246196001217 L-aspartate oxidase; Provisional; Region: PRK06175 246196001218 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196001219 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196001220 tetramer interface [polypeptide binding]; other site 246196001221 active site 246196001222 Mg2+/Mn2+ binding site [ion binding]; other site 246196001223 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246196001224 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246196001225 putative dimer interface [polypeptide binding]; other site 246196001226 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246196001227 EamA-like transporter family; Region: EamA; pfam00892 246196001228 EamA-like transporter family; Region: EamA; pfam00892 246196001229 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196001230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001231 DNA-binding site [nucleotide binding]; DNA binding site 246196001232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196001233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196001234 homodimer interface [polypeptide binding]; other site 246196001235 catalytic residue [active] 246196001236 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 246196001237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196001238 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 246196001239 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196001240 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 246196001241 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 246196001242 Peptidase M15; Region: Peptidase_M15_3; cl01194 246196001243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196001244 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196001245 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 246196001246 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196001247 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 246196001248 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 246196001249 putative active site [active] 246196001250 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 246196001251 active site 246196001252 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 246196001253 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 246196001254 active site 246196001255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 246196001256 DNA binding site [nucleotide binding] 246196001257 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 246196001258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001259 putative substrate translocation pore; other site 246196001260 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 246196001261 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 246196001262 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 246196001263 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 246196001264 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 246196001265 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196001266 intersubunit interface [polypeptide binding]; other site 246196001267 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 246196001268 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196001269 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196001270 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 246196001271 tetracycline repressor protein TetR; Provisional; Region: PRK13756 246196001272 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 246196001273 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196001274 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 246196001275 active site 246196001276 catalytic triad [active] 246196001277 dimer interface [polypeptide binding]; other site 246196001278 Amidinotransferase; Region: Amidinotransf; cl19186 246196001279 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196001280 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 246196001281 active site 246196001282 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196001283 amino acid transporter; Region: 2A0306; TIGR00909 246196001284 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 246196001285 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196001286 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196001287 putative Zn2+ binding site [ion binding]; other site 246196001288 putative DNA binding site [nucleotide binding]; other site 246196001289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196001291 putative substrate translocation pore; other site 246196001292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196001293 Ligand Binding Site [chemical binding]; other site 246196001294 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 246196001295 fructuronate transporter; Provisional; Region: PRK10034; cl15264 246196001296 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 246196001297 AAA domain; Region: AAA_33; pfam13671 246196001298 ATP-binding site [chemical binding]; other site 246196001299 Gluconate-6-phosphate binding site [chemical binding]; other site 246196001300 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196001301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001302 DNA-binding site [nucleotide binding]; DNA binding site 246196001303 FCD domain; Region: FCD; pfam07729 246196001304 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 246196001305 NAD binding site [chemical binding]; other site 246196001306 catalytic residues [active] 246196001307 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 246196001308 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 246196001309 CAP-like domain; other site 246196001310 active site 246196001311 primary dimer interface [polypeptide binding]; other site 246196001312 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246196001313 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 246196001314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196001315 Mg2+ binding site [ion binding]; other site 246196001316 G-X-G motif; other site 246196001317 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 246196001318 ATP binding site [chemical binding]; other site 246196001319 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 246196001320 active site 246196001321 metal binding site [ion binding]; metal-binding site 246196001322 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246196001323 Putative sensor; Region: Sensor; pfam13796 246196001324 Histidine kinase; Region: HisKA_3; pfam07730 246196001325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196001326 ATP binding site [chemical binding]; other site 246196001327 Mg2+ binding site [ion binding]; other site 246196001328 G-X-G motif; other site 246196001329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196001330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196001331 active site 246196001332 phosphorylation site [posttranslational modification] 246196001333 intermolecular recognition site; other site 246196001334 dimerization interface [polypeptide binding]; other site 246196001335 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196001336 DNA binding residues [nucleotide binding] 246196001337 dimerization interface [polypeptide binding]; other site 246196001338 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196001339 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196001340 Uncharacterized conserved protein [Function unknown]; Region: COG1739 246196001341 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 246196001342 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 246196001343 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196001344 Transport protein; Region: actII; TIGR00833 246196001345 MMPL family; Region: MMPL; pfam03176 246196001346 MMPL family; Region: MMPL; pfam03176 246196001347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001349 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 246196001350 substrate binding site [chemical binding]; other site 246196001351 dimer interface [polypeptide binding]; other site 246196001352 ATP binding site [chemical binding]; other site 246196001353 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 246196001354 Lysine efflux permease [General function prediction only]; Region: COG1279 246196001355 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196001356 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196001357 putative Zn2+ binding site [ion binding]; other site 246196001358 putative DNA binding site [nucleotide binding]; other site 246196001359 dimerization interface [polypeptide binding]; other site 246196001360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 246196001361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196001362 Coenzyme A binding pocket [chemical binding]; other site 246196001363 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 246196001364 EamA-like transporter family; Region: EamA; pfam00892 246196001365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196001366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196001367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196001368 dimerization interface [polypeptide binding]; other site 246196001369 Carboxylesterase family; Region: COesterase; pfam00135 246196001370 substrate binding pocket [chemical binding]; other site 246196001371 catalytic triad [active] 246196001372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196001373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196001374 active site 246196001375 intermolecular recognition site; other site 246196001376 dimerization interface [polypeptide binding]; other site 246196001377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196001378 DNA binding residues [nucleotide binding] 246196001379 dimerization interface [polypeptide binding]; other site 246196001380 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246196001381 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246196001382 glutaminase active site [active] 246196001383 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196001384 dimer interface [polypeptide binding]; other site 246196001385 active site 246196001386 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246196001387 dimer interface [polypeptide binding]; other site 246196001388 active site 246196001389 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 246196001390 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 246196001391 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246196001392 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246196001393 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 246196001394 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 246196001395 DXD motif; other site 246196001396 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 246196001397 putative active site [active] 246196001398 putative metal binding site [ion binding]; other site 246196001399 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196001400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001401 DNA-binding site [nucleotide binding]; DNA binding site 246196001402 FCD domain; Region: FCD; pfam07729 246196001403 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 246196001404 Dehydratase family; Region: ILVD_EDD; pfam00920 246196001405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001406 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196001407 putative substrate translocation pore; other site 246196001408 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 246196001409 amidase; Provisional; Region: PRK07235 246196001410 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196001411 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196001412 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196001413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001414 dimer interface [polypeptide binding]; other site 246196001415 conserved gate region; other site 246196001416 putative PBP binding loops; other site 246196001417 ABC-ATPase subunit interface; other site 246196001418 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196001419 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196001420 Walker A/P-loop; other site 246196001421 ATP binding site [chemical binding]; other site 246196001422 Q-loop/lid; other site 246196001423 ABC transporter signature motif; other site 246196001424 Walker B; other site 246196001425 D-loop; other site 246196001426 H-loop/switch region; other site 246196001427 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196001428 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196001429 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196001430 substrate binding site [chemical binding]; other site 246196001431 oxyanion hole (OAH) forming residues; other site 246196001432 trimer interface [polypeptide binding]; other site 246196001433 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196001434 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196001435 DNA binding site [nucleotide binding] 246196001436 domain linker motif; other site 246196001437 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196001438 dimerization interface [polypeptide binding]; other site 246196001439 ligand binding site [chemical binding]; other site 246196001440 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 246196001441 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 246196001442 Dehydratase large subunit; Region: Dehydratase_LU; pfam02286 246196001443 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 246196001444 alpha-beta subunit interface [polypeptide binding]; other site 246196001445 alpha-gamma subunit interface [polypeptide binding]; other site 246196001446 active site 246196001447 substrate and K+ binding site; other site 246196001448 K+ binding site [ion binding]; other site 246196001449 cobalamin binding site [chemical binding]; other site 246196001450 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 246196001451 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196001452 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196001453 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196001454 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196001455 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 246196001456 active site 246196001457 trimer interface [polypeptide binding]; other site 246196001458 allosteric site; other site 246196001459 active site lid [active] 246196001460 hexamer (dimer of trimers) interface [polypeptide binding]; other site 246196001461 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 246196001462 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 246196001463 NAD binding site [chemical binding]; other site 246196001464 sugar binding site [chemical binding]; other site 246196001465 divalent metal binding site [ion binding]; other site 246196001466 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246196001467 dimer interface [polypeptide binding]; other site 246196001468 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196001469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196001470 putative DNA binding site [nucleotide binding]; other site 246196001471 putative Zn2+ binding site [ion binding]; other site 246196001472 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196001473 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246196001474 ATP binding site [chemical binding]; other site 246196001475 substrate binding site [chemical binding]; other site 246196001476 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196001477 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246196001478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001479 dimer interface [polypeptide binding]; other site 246196001480 conserved gate region; other site 246196001481 putative PBP binding loops; other site 246196001482 ABC-ATPase subunit interface; other site 246196001483 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196001484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001485 dimer interface [polypeptide binding]; other site 246196001486 conserved gate region; other site 246196001487 putative PBP binding loops; other site 246196001488 ABC-ATPase subunit interface; other site 246196001489 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196001490 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246196001491 Walker A/P-loop; other site 246196001492 ATP binding site [chemical binding]; other site 246196001493 Q-loop/lid; other site 246196001494 ABC transporter signature motif; other site 246196001495 Walker B; other site 246196001496 D-loop; other site 246196001497 H-loop/switch region; other site 246196001498 TOBE domain; Region: TOBE_2; pfam08402 246196001499 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196001500 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 246196001501 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196001502 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 246196001503 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 246196001504 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196001505 dimer interface [polypeptide binding]; other site 246196001506 active site 246196001507 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 246196001508 putative active site [active] 246196001509 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196001510 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246196001511 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196001512 nucleotide binding site [chemical binding]; other site 246196001513 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246196001514 EamA-like transporter family; Region: EamA; cl17759 246196001515 EamA-like transporter family; Region: EamA; pfam00892 246196001516 alpha-galactosidase; Provisional; Region: PRK15076 246196001517 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 246196001518 NAD binding site [chemical binding]; other site 246196001519 sugar binding site [chemical binding]; other site 246196001520 divalent metal binding site [ion binding]; other site 246196001521 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 246196001522 dimer interface [polypeptide binding]; other site 246196001523 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196001524 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196001525 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196001526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001527 dimer interface [polypeptide binding]; other site 246196001528 conserved gate region; other site 246196001529 putative PBP binding loops; other site 246196001530 ABC-ATPase subunit interface; other site 246196001531 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196001532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001533 dimer interface [polypeptide binding]; other site 246196001534 conserved gate region; other site 246196001535 putative PBP binding loops; other site 246196001536 ABC-ATPase subunit interface; other site 246196001537 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196001538 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246196001539 Walker A/P-loop; other site 246196001540 ATP binding site [chemical binding]; other site 246196001541 Q-loop/lid; other site 246196001542 ABC transporter signature motif; other site 246196001543 Walker B; other site 246196001544 D-loop; other site 246196001545 H-loop/switch region; other site 246196001546 TOBE domain; Region: TOBE_2; pfam08402 246196001547 MspA; Region: MspA; pfam09203 246196001548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196001549 salt bridge; other site 246196001550 non-specific DNA binding site [nucleotide binding]; other site 246196001551 sequence-specific DNA binding site [nucleotide binding]; other site 246196001552 short chain dehydrogenase; Provisional; Region: PRK06180 246196001553 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196001554 NADP binding site [chemical binding]; other site 246196001555 active site 246196001556 steroid binding site; other site 246196001557 choline dehydrogenase; Validated; Region: PRK02106 246196001558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196001559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196001560 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196001561 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196001562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001563 NAD(P) binding site [chemical binding]; other site 246196001564 active site 246196001565 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196001566 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196001567 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196001568 active site 246196001569 ATP binding site [chemical binding]; other site 246196001570 substrate binding site [chemical binding]; other site 246196001571 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196001572 substrate binding site [chemical binding]; other site 246196001573 activation loop (A-loop); other site 246196001574 activation loop (A-loop); other site 246196001575 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 246196001576 AAA ATPase domain; Region: AAA_16; pfam13191 246196001577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196001578 TPR motif; other site 246196001579 binding surface 246196001580 short chain dehydrogenase; Provisional; Region: PRK07806 246196001581 NAD(P) binding site [chemical binding]; other site 246196001582 active site 246196001583 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001584 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196001585 active site 246196001586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001588 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 246196001589 substrate binding site [chemical binding]; other site 246196001590 amidase catalytic site [active] 246196001591 Zn binding residues [ion binding]; other site 246196001592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001593 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196001594 putative substrate translocation pore; other site 246196001595 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196001596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196001597 DNA-binding site [nucleotide binding]; DNA binding site 246196001598 FCD domain; Region: FCD; pfam07729 246196001599 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 246196001600 intracellular protease, PfpI family; Region: PfpI; TIGR01382 246196001601 proposed catalytic triad [active] 246196001602 conserved cys residue [active] 246196001603 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196001604 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196001605 putative DNA binding site [nucleotide binding]; other site 246196001606 putative Zn2+ binding site [ion binding]; other site 246196001607 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196001608 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196001609 ligand binding site [chemical binding]; other site 246196001610 flexible hinge region; other site 246196001611 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 246196001612 putative switch regulator; other site 246196001613 non-specific DNA interactions [nucleotide binding]; other site 246196001614 DNA binding site [nucleotide binding] 246196001615 sequence specific DNA binding site [nucleotide binding]; other site 246196001616 putative cAMP binding site [chemical binding]; other site 246196001617 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 246196001618 PAS fold; Region: PAS_3; pfam08447 246196001619 ANTAR domain; Region: ANTAR; pfam03861 246196001620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196001621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196001622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196001623 dimerization interface [polypeptide binding]; other site 246196001624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196001625 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196001626 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 246196001627 metal binding site [ion binding]; metal-binding site 246196001628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196001629 S-adenosylmethionine binding site [chemical binding]; other site 246196001630 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 246196001631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196001632 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196001633 dimerization interface [polypeptide binding]; other site 246196001634 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196001635 Winged helix-turn helix; Region: HTH_29; pfam13551 246196001636 Homeodomain-like domain; Region: HTH_32; pfam13565 246196001637 DDE superfamily endonuclease; Region: DDE_3; cl19249 246196001638 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196001639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001640 dimer interface [polypeptide binding]; other site 246196001641 conserved gate region; other site 246196001642 putative PBP binding loops; other site 246196001643 ABC-ATPase subunit interface; other site 246196001644 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196001645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196001646 substrate binding pocket [chemical binding]; other site 246196001647 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196001648 membrane-bound complex binding site; other site 246196001649 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196001650 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196001651 Walker A/P-loop; other site 246196001652 ATP binding site [chemical binding]; other site 246196001653 Q-loop/lid; other site 246196001654 ABC transporter signature motif; other site 246196001655 Walker B; other site 246196001656 D-loop; other site 246196001657 H-loop/switch region; other site 246196001658 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 246196001659 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196001660 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 246196001661 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196001662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001663 dimer interface [polypeptide binding]; other site 246196001664 conserved gate region; other site 246196001665 putative PBP binding loops; other site 246196001666 ABC-ATPase subunit interface; other site 246196001667 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196001668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001669 dimer interface [polypeptide binding]; other site 246196001670 conserved gate region; other site 246196001671 putative PBP binding loops; other site 246196001672 ABC-ATPase subunit interface; other site 246196001673 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 246196001674 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 246196001675 Walker A/P-loop; other site 246196001676 ATP binding site [chemical binding]; other site 246196001677 Q-loop/lid; other site 246196001678 ABC transporter signature motif; other site 246196001679 Walker B; other site 246196001680 D-loop; other site 246196001681 H-loop/switch region; other site 246196001682 TOBE domain; Region: TOBE_2; pfam08402 246196001683 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246196001684 DNA-binding site [nucleotide binding]; DNA binding site 246196001685 RNA-binding motif; other site 246196001686 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196001687 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196001688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001689 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 246196001690 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196001691 Protein of unknown function (DUF808); Region: DUF808; cl01002 246196001692 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 246196001693 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 246196001694 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196001695 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 246196001696 active site 246196001697 catalytic triad [active] 246196001698 dimer interface [polypeptide binding]; other site 246196001699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196001700 Coenzyme A binding pocket [chemical binding]; other site 246196001701 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 246196001702 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 246196001703 dimerization interface [polypeptide binding]; other site 246196001704 putative ATP binding site [chemical binding]; other site 246196001705 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 246196001706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196001707 FeS/SAM binding site; other site 246196001708 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 246196001709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196001710 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 246196001711 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 246196001712 active site 246196001713 catalytic triad [active] 246196001714 dimer interface [polypeptide binding]; other site 246196001715 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 246196001716 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 246196001717 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196001718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196001719 DNA binding residues [nucleotide binding] 246196001720 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 246196001721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196001722 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196001723 DNA binding residues [nucleotide binding] 246196001724 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196001725 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196001726 MMPL family; Region: MMPL; pfam03176 246196001727 MMPL family; Region: MMPL; pfam03176 246196001728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001729 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196001730 putative substrate translocation pore; other site 246196001731 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001732 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196001733 active site 246196001734 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196001735 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196001736 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196001737 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196001738 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196001739 inhibitor-cofactor binding pocket; inhibition site 246196001740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196001741 catalytic residue [active] 246196001742 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 246196001743 tetramerization interface [polypeptide binding]; other site 246196001744 NAD(P) binding site [chemical binding]; other site 246196001745 catalytic residues [active] 246196001746 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196001747 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 246196001748 Domain of unknown function (DUF718); Region: DUF718; pfam05336 246196001749 benzoate transport; Region: 2A0115; TIGR00895 246196001750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196001751 putative substrate translocation pore; other site 246196001752 L-rhamnose isomerase (RhaA); Region: RhaA; cl19165 246196001753 short chain dehydrogenase; Validated; Region: PRK08324 246196001754 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 246196001755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196001756 NAD(P) binding site [chemical binding]; other site 246196001757 active site 246196001758 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 246196001759 N- and C-terminal domain interface [polypeptide binding]; other site 246196001760 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 246196001761 active site 246196001762 putative catalytic site [active] 246196001763 metal binding site [ion binding]; metal-binding site 246196001764 ATP binding site [chemical binding]; other site 246196001765 carbohydrate binding site [chemical binding]; other site 246196001766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196001767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196001768 DNA binding site [nucleotide binding] 246196001769 domain linker motif; other site 246196001770 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196001771 ligand binding site [chemical binding]; other site 246196001772 dimerization interface [polypeptide binding]; other site 246196001773 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 246196001774 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 246196001775 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 246196001776 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 246196001777 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 246196001778 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246196001779 Cysteine-rich domain; Region: CCG; pfam02754 246196001780 Cysteine-rich domain; Region: CCG; pfam02754 246196001781 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196001782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001783 DNA-binding site [nucleotide binding]; DNA binding site 246196001784 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196001785 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 246196001786 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 246196001787 nucleotide binding site [chemical binding]; other site 246196001788 acyl-CoA synthetase; Validated; Region: PRK07788 246196001789 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196001790 acyl-activating enzyme (AAE) consensus motif; other site 246196001791 putative AMP binding site [chemical binding]; other site 246196001792 putative active site [active] 246196001793 putative CoA binding site [chemical binding]; other site 246196001794 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196001795 classical (c) SDRs; Region: SDR_c; cd05233 246196001796 NAD(P) binding site [chemical binding]; other site 246196001797 active site 246196001798 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001799 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196001800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196001801 active site 246196001802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196001803 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196001804 active site 246196001805 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 246196001806 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 246196001807 putative ligand binding site [chemical binding]; other site 246196001808 putative NAD binding site [chemical binding]; other site 246196001809 catalytic site [active] 246196001810 Esterase/lipase [General function prediction only]; Region: COG1647 246196001811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001813 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 246196001814 Zn binding site [ion binding]; other site 246196001815 Leucine carboxyl methyltransferase; Region: LCM; cl01306 246196001816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196001817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196001818 salt bridge; other site 246196001819 non-specific DNA binding site [nucleotide binding]; other site 246196001820 sequence-specific DNA binding site [nucleotide binding]; other site 246196001821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196001822 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 246196001823 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 246196001824 substrate binding pocket [chemical binding]; other site 246196001825 catalytic triad [active] 246196001826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001827 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 246196001828 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 246196001829 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 246196001830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196001831 Walker A motif; other site 246196001832 ATP binding site [chemical binding]; other site 246196001833 Walker B motif; other site 246196001834 arginine finger; other site 246196001835 Protein of unknown function (DUF690); Region: DUF690; cl04939 246196001836 FliP family; Region: FliP; cl00593 246196001837 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 246196001838 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196001839 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 246196001840 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196001841 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196001842 PE family; Region: PE; pfam00934 246196001843 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 246196001844 PPE family; Region: PPE; pfam00823 246196001845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 246196001846 EspG family; Region: ESX-1_EspG; pfam14011 246196001847 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 246196001848 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 246196001849 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 246196001850 catalytic triad [active] 246196001851 putative active site [active] 246196001852 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 246196001853 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196001854 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196001855 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 246196001856 Amidohydrolase; Region: Amidohydro_4; pfam13147 246196001857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 246196001858 active site 246196001859 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 246196001860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196001861 S-adenosylmethionine binding site [chemical binding]; other site 246196001862 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 246196001863 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 246196001864 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 246196001865 active site 246196001866 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 246196001867 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 246196001868 active site 246196001869 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 246196001870 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246196001871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 246196001872 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 246196001873 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 246196001874 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196001875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196001876 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196001877 iron-sulfur cluster [ion binding]; other site 246196001878 [2Fe-2S] cluster binding site [ion binding]; other site 246196001879 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196001880 nucleotide binding site [chemical binding]; other site 246196001881 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 246196001882 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196001883 Walker A/P-loop; other site 246196001884 ATP binding site [chemical binding]; other site 246196001885 Q-loop/lid; other site 246196001886 ABC transporter signature motif; other site 246196001887 Walker B; other site 246196001888 D-loop; other site 246196001889 H-loop/switch region; other site 246196001890 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196001891 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 246196001892 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196001893 Walker A/P-loop; other site 246196001894 ATP binding site [chemical binding]; other site 246196001895 Q-loop/lid; other site 246196001896 ABC transporter signature motif; other site 246196001897 Walker B; other site 246196001898 D-loop; other site 246196001899 H-loop/switch region; other site 246196001900 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196001901 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196001902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001903 dimer interface [polypeptide binding]; other site 246196001904 conserved gate region; other site 246196001905 putative PBP binding loops; other site 246196001906 ABC-ATPase subunit interface; other site 246196001907 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196001908 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 246196001909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001910 dimer interface [polypeptide binding]; other site 246196001911 conserved gate region; other site 246196001912 putative PBP binding loops; other site 246196001913 ABC-ATPase subunit interface; other site 246196001914 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196001915 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 246196001916 peptide binding site [polypeptide binding]; other site 246196001917 Cupin domain; Region: Cupin_2; pfam07883 246196001918 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 246196001919 active site 246196001920 catalytic residues [active] 246196001921 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 246196001922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001923 dimer interface [polypeptide binding]; other site 246196001924 conserved gate region; other site 246196001925 putative PBP binding loops; other site 246196001926 ABC-ATPase subunit interface; other site 246196001927 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 246196001928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001929 dimer interface [polypeptide binding]; other site 246196001930 conserved gate region; other site 246196001931 putative PBP binding loops; other site 246196001932 ABC-ATPase subunit interface; other site 246196001933 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 246196001934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196001935 Walker A/P-loop; other site 246196001936 ATP binding site [chemical binding]; other site 246196001937 Q-loop/lid; other site 246196001938 ABC transporter signature motif; other site 246196001939 Walker B; other site 246196001940 D-loop; other site 246196001941 H-loop/switch region; other site 246196001942 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 246196001943 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 246196001944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196001945 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196001946 DNA-binding site [nucleotide binding]; DNA binding site 246196001947 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 246196001948 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196001949 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196001950 classical (c) SDRs; Region: SDR_c; cd05233 246196001951 NAD(P) binding site [chemical binding]; other site 246196001952 active site 246196001953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196001954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001955 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196001956 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196001957 [2Fe-2S] cluster binding site [ion binding]; other site 246196001958 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 246196001959 putative alpha subunit interface [polypeptide binding]; other site 246196001960 putative active site [active] 246196001961 putative substrate binding site [chemical binding]; other site 246196001962 Fe binding site [ion binding]; other site 246196001963 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196001964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001965 dimer interface [polypeptide binding]; other site 246196001966 conserved gate region; other site 246196001967 putative PBP binding loops; other site 246196001968 ABC-ATPase subunit interface; other site 246196001969 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196001970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196001971 dimer interface [polypeptide binding]; other site 246196001972 conserved gate region; other site 246196001973 putative PBP binding loops; other site 246196001974 ABC-ATPase subunit interface; other site 246196001975 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 246196001976 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 246196001977 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196001978 inhibitor-cofactor binding pocket; inhibition site 246196001979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196001980 catalytic residue [active] 246196001981 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196001982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196001983 Walker A/P-loop; other site 246196001984 ATP binding site [chemical binding]; other site 246196001985 Q-loop/lid; other site 246196001986 ABC transporter signature motif; other site 246196001987 Walker B; other site 246196001988 D-loop; other site 246196001989 H-loop/switch region; other site 246196001990 TOBE domain; Region: TOBE_2; pfam08402 246196001991 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 246196001992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196001993 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246196001994 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246196001995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196001996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196001997 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 246196001998 CoA binding domain; Region: CoA_binding_2; pfam13380 246196001999 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 246196002000 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 246196002001 FAD dependent oxidoreductase; Region: DAO; pfam01266 246196002002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196002003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196002004 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196002005 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196002006 active site 246196002007 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 246196002008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196002009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196002010 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 246196002011 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196002012 NAD binding site [chemical binding]; other site 246196002013 catalytic Zn binding site [ion binding]; other site 246196002014 structural Zn binding site [ion binding]; other site 246196002015 GAF domain; Region: GAF_2; pfam13185 246196002016 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 246196002017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196002018 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196002019 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196002020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002021 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 246196002022 trimer interface [polypeptide binding]; other site 246196002023 active site 246196002024 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 246196002025 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 246196002026 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246196002027 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246196002028 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196002029 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196002030 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196002031 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 246196002032 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196002033 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196002034 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196002035 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196002036 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196002037 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 246196002038 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 246196002039 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196002040 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196002041 catalytic loop [active] 246196002042 iron binding site [ion binding]; other site 246196002043 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196002044 YibE/F-like protein; Region: YibE_F; pfam07907 246196002045 aminotransferase AlaT; Validated; Region: PRK09265 246196002046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196002047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002048 homodimer interface [polypeptide binding]; other site 246196002049 catalytic residue [active] 246196002050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 246196002051 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246196002052 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 246196002053 Cysteine-rich domain; Region: CCG; pfam02754 246196002054 Cysteine-rich domain; Region: CCG; pfam02754 246196002055 AAA ATPase domain; Region: AAA_16; pfam13191 246196002056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196002057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196002058 DNA binding residues [nucleotide binding] 246196002059 dimerization interface [polypeptide binding]; other site 246196002060 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196002061 nucleotide binding site [chemical binding]; other site 246196002062 DNA translocase FtsK; Provisional; Region: PRK10263 246196002063 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 246196002064 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246196002065 G1 box; other site 246196002066 GTP/Mg2+ binding site [chemical binding]; other site 246196002067 G2 box; other site 246196002068 Switch I region; other site 246196002069 G3 box; other site 246196002070 Switch II region; other site 246196002071 G4 box; other site 246196002072 G5 box; other site 246196002073 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 246196002074 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 246196002075 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 246196002076 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246196002077 G1 box; other site 246196002078 GTP/Mg2+ binding site [chemical binding]; other site 246196002079 G2 box; other site 246196002080 Switch I region; other site 246196002081 G3 box; other site 246196002082 Switch II region; other site 246196002083 G4 box; other site 246196002084 G5 box; other site 246196002085 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196002086 nucleotide binding site [chemical binding]; other site 246196002087 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196002088 TIGR03085 family protein; Region: TIGR03085 246196002089 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196002090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002091 D-galactonate transporter; Region: 2A0114; TIGR00893 246196002092 putative substrate translocation pore; other site 246196002093 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 246196002094 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 246196002095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196002096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196002097 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 246196002098 putative dimerization interface [polypeptide binding]; other site 246196002099 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 246196002100 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 246196002101 nucleotide binding site [chemical binding]; other site 246196002102 NEF interaction site [polypeptide binding]; other site 246196002103 SBD interface [polypeptide binding]; other site 246196002104 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 246196002105 dimer interface [polypeptide binding]; other site 246196002106 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 246196002107 chaperone protein DnaJ; Provisional; Region: PRK14279 246196002108 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246196002109 HSP70 interaction site [polypeptide binding]; other site 246196002110 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 246196002111 Zn binding sites [ion binding]; other site 246196002112 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 246196002113 dimer interface [polypeptide binding]; other site 246196002114 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196002115 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 246196002116 DNA binding residues [nucleotide binding] 246196002117 putative dimer interface [polypeptide binding]; other site 246196002118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002120 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196002121 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196002122 active site 246196002123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002124 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246196002125 NAD(P) binding site [chemical binding]; other site 246196002126 active site 246196002127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002128 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196002129 putative substrate translocation pore; other site 246196002130 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 246196002131 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196002132 acyl-activating enzyme (AAE) consensus motif; other site 246196002133 AMP binding site [chemical binding]; other site 246196002134 active site 246196002135 CoA binding site [chemical binding]; other site 246196002136 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 246196002137 active site 246196002138 catalytic residues [active] 246196002139 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 246196002140 heme-binding site [chemical binding]; other site 246196002141 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 246196002142 FMN reductase; Validated; Region: fre; PRK08051 246196002143 FAD binding pocket [chemical binding]; other site 246196002144 FAD binding motif [chemical binding]; other site 246196002145 phosphate binding motif [ion binding]; other site 246196002146 beta-alpha-beta structure motif; other site 246196002147 NAD binding pocket [chemical binding]; other site 246196002148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196002149 Transposase; Region: HTH_Tnp_1; cl17663 246196002150 putative transposase OrfB; Reviewed; Region: PHA02517 246196002151 HTH-like domain; Region: HTH_21; pfam13276 246196002152 Integrase core domain; Region: rve; pfam00665 246196002153 Integrase core domain; Region: rve_3; pfam13683 246196002154 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196002155 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196002156 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196002157 active site 246196002158 TDP-binding site; other site 246196002159 glycosyltransferase, MGT family; Region: MGT; TIGR01426 246196002160 acceptor substrate-binding pocket; other site 246196002161 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 246196002162 putative active site [active] 246196002163 putative metal binding residues [ion binding]; other site 246196002164 signature motif; other site 246196002165 putative dimer interface [polypeptide binding]; other site 246196002166 putative phosphate binding site [ion binding]; other site 246196002167 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 246196002168 Clp amino terminal domain; Region: Clp_N; pfam02861 246196002169 Clp amino terminal domain; Region: Clp_N; pfam02861 246196002170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002171 Walker A motif; other site 246196002172 ATP binding site [chemical binding]; other site 246196002173 Walker B motif; other site 246196002174 arginine finger; other site 246196002175 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 246196002176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002177 Walker A motif; other site 246196002178 ATP binding site [chemical binding]; other site 246196002179 Walker B motif; other site 246196002180 arginine finger; other site 246196002181 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246196002182 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196002183 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196002184 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196002185 [2Fe-2S] cluster binding site [ion binding]; other site 246196002186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 246196002187 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 246196002188 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 246196002189 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196002190 classical (c) SDRs; Region: SDR_c; cd05233 246196002191 NAD(P) binding site [chemical binding]; other site 246196002192 active site 246196002193 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 246196002194 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246196002195 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 246196002196 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196002197 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196002198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196002199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196002200 LysR substrate binding domain; Region: LysR_substrate; pfam03466 246196002201 dimerization interface [polypeptide binding]; other site 246196002202 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 246196002203 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246196002204 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246196002205 XdhC Rossmann domain; Region: XdhC_C; pfam13478 246196002206 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 246196002207 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196002208 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 246196002209 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196002210 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196002211 catalytic loop [active] 246196002212 iron binding site [ion binding]; other site 246196002213 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196002214 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 246196002215 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 246196002216 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196002217 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 246196002218 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246196002219 XdhC Rossmann domain; Region: XdhC_C; pfam13478 246196002220 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196002221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002222 Walker A motif; other site 246196002223 ATP binding site [chemical binding]; other site 246196002224 Walker B motif; other site 246196002225 arginine finger; other site 246196002226 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 246196002227 putative hydrophobic ligand binding site [chemical binding]; other site 246196002228 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 246196002229 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246196002230 metal ion-dependent adhesion site (MIDAS); other site 246196002231 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 246196002232 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 246196002233 active site 246196002234 intersubunit interface [polypeptide binding]; other site 246196002235 zinc binding site [ion binding]; other site 246196002236 Na+ binding site [ion binding]; other site 246196002237 Domain of unknown function (DUF697); Region: DUF697; cl12064 246196002238 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 246196002239 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 246196002240 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 246196002241 Peptidase family M50; Region: Peptidase_M50; pfam02163 246196002242 active site 246196002243 putative substrate binding region [chemical binding]; other site 246196002244 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 246196002245 GDP-binding site [chemical binding]; other site 246196002246 ACT binding site; other site 246196002247 IMP binding site; other site 246196002248 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196002249 CoenzymeA binding site [chemical binding]; other site 246196002250 subunit interaction site [polypeptide binding]; other site 246196002251 PHB binding site; other site 246196002252 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196002253 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196002254 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196002255 MMPL family; Region: MMPL; cl14618 246196002256 MMPL family; Region: MMPL; cl14618 246196002257 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 246196002258 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 246196002259 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 246196002260 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 246196002261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196002263 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 246196002264 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196002265 active site residue [active] 246196002266 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246196002267 homodimer interface [polypeptide binding]; other site 246196002268 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 246196002269 substrate-cofactor binding pocket; other site 246196002270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002271 catalytic residue [active] 246196002272 short chain dehydrogenase; Provisional; Region: PRK07825 246196002273 classical (c) SDRs; Region: SDR_c; cd05233 246196002274 NAD(P) binding site [chemical binding]; other site 246196002275 active site 246196002276 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 246196002277 SdiA-regulated; Region: SdiA-regulated; cl19046 246196002278 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 246196002279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196002280 Coenzyme A binding pocket [chemical binding]; other site 246196002281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196002282 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196002283 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196002284 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196002285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196002286 DNA-binding site [nucleotide binding]; DNA binding site 246196002287 UTRA domain; Region: UTRA; pfam07702 246196002288 short chain dehydrogenase; Provisional; Region: PRK12829 246196002289 classical (c) SDRs; Region: SDR_c; cd05233 246196002290 NAD(P) binding site [chemical binding]; other site 246196002291 active site 246196002292 Phosphotransferase enzyme family; Region: APH; pfam01636 246196002293 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 246196002294 active site 246196002295 ATP binding site [chemical binding]; other site 246196002296 Amino acid permease; Region: AA_permease_2; pfam13520 246196002297 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196002298 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196002299 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196002300 inhibitor-cofactor binding pocket; inhibition site 246196002301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002302 catalytic residue [active] 246196002303 phosphate acetyltransferase; Reviewed; Region: PRK05632 246196002304 DRTGG domain; Region: DRTGG; pfam07085 246196002305 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 246196002306 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 246196002307 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196002308 putative active site [active] 246196002309 Nudix N-terminal; Region: Nudix_N_2; pfam14803 246196002310 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196002311 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196002312 active site 246196002313 ATP binding site [chemical binding]; other site 246196002314 substrate binding site [chemical binding]; other site 246196002315 activation loop (A-loop); other site 246196002316 Protein of unknown function (DUF406); Region: DUF406; cl11449 246196002317 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 246196002318 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196002319 substrate binding pocket [chemical binding]; other site 246196002320 membrane-bound complex binding site; other site 246196002321 hinge residues; other site 246196002322 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 246196002323 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 246196002324 nudix motif; other site 246196002325 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 246196002326 thiamine phosphate binding site [chemical binding]; other site 246196002327 active site 246196002328 pyrophosphate binding site [ion binding]; other site 246196002329 FAD dependent oxidoreductase; Region: DAO; pfam01266 246196002330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196002331 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 246196002332 thiS-thiF/thiG interaction site; other site 246196002333 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 246196002334 ThiS interaction site; other site 246196002335 putative active site [active] 246196002336 tetramer interface [polypeptide binding]; other site 246196002337 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 246196002338 active site 246196002339 catalytic triad [active] 246196002340 oxyanion hole [active] 246196002341 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196002342 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 246196002343 Walker A/P-loop; other site 246196002344 ATP binding site [chemical binding]; other site 246196002345 Q-loop/lid; other site 246196002346 ABC transporter signature motif; other site 246196002347 Walker B; other site 246196002348 D-loop; other site 246196002349 H-loop/switch region; other site 246196002350 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 246196002351 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196002352 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196002353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196002354 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196002355 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 246196002356 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 246196002357 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 246196002358 PA/protease or protease-like domain interface [polypeptide binding]; other site 246196002359 active site 246196002360 metal binding site [ion binding]; metal-binding site 246196002361 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 246196002362 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 246196002363 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 246196002364 PA/protease or protease-like domain interface [polypeptide binding]; other site 246196002365 active site 246196002366 metal binding site [ion binding]; metal-binding site 246196002367 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 246196002368 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 246196002369 malonyl-CoA binding site [chemical binding]; other site 246196002370 dimer interface [polypeptide binding]; other site 246196002371 active site 246196002372 product binding site; other site 246196002373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 246196002374 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246196002375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196002376 Sulfate transporter family; Region: Sulfate_transp; cl19250 246196002377 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 246196002378 ethanolamine permease; Region: 2A0305; TIGR00908 246196002379 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196002380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002384 Predicted membrane protein [Function unknown]; Region: COG4270 246196002385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196002386 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196002387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196002388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196002389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196002390 dimerization interface [polypeptide binding]; other site 246196002391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002392 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196002393 putative substrate translocation pore; other site 246196002394 allantoate amidohydrolase; Reviewed; Region: PRK09290 246196002395 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 246196002396 active site 246196002397 metal binding site [ion binding]; metal-binding site 246196002398 dimer interface [polypeptide binding]; other site 246196002399 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196002400 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 246196002401 Cytochrome P450; Region: p450; cl12078 246196002402 Septum formation; Region: Septum_form; pfam13845 246196002403 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196002404 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246196002405 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 246196002406 dimer interface [polypeptide binding]; other site 246196002407 substrate binding site [chemical binding]; other site 246196002408 ATP binding site [chemical binding]; other site 246196002409 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 246196002410 ThiC-associated domain; Region: ThiC-associated; pfam13667 246196002411 ThiC family; Region: ThiC; pfam01964 246196002412 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 246196002413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002414 putative substrate translocation pore; other site 246196002415 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 246196002416 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 246196002417 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 246196002418 putative catalytic site [active] 246196002419 putative phosphate binding site [ion binding]; other site 246196002420 active site 246196002421 metal binding site A [ion binding]; metal-binding site 246196002422 DNA binding site [nucleotide binding] 246196002423 putative AP binding site [nucleotide binding]; other site 246196002424 putative metal binding site B [ion binding]; other site 246196002425 short chain dehydrogenase; Provisional; Region: PRK07577 246196002426 classical (c) SDRs; Region: SDR_c; cd05233 246196002427 NAD(P) binding site [chemical binding]; other site 246196002428 active site 246196002429 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196002430 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 246196002431 active site 246196002432 catalytic residues [active] 246196002433 metal binding site [ion binding]; metal-binding site 246196002434 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 246196002435 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196002436 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 246196002437 E-class dimer interface [polypeptide binding]; other site 246196002438 P-class dimer interface [polypeptide binding]; other site 246196002439 active site 246196002440 Cu2+ binding site [ion binding]; other site 246196002441 Zn2+ binding site [ion binding]; other site 246196002442 carboxylate-amine ligase; Provisional; Region: PRK13517 246196002443 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196002444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196002445 putative DNA binding site [nucleotide binding]; other site 246196002446 putative Zn2+ binding site [ion binding]; other site 246196002447 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196002448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196002449 ATP-dependent protease La (LON) domain; Region: LON; cl19481 246196002450 Reoviral Sigma1/Sigma2 family; Region: Sigma_1_2; pfam03084 246196002451 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 246196002452 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 246196002453 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 246196002454 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 246196002455 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196002456 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 246196002457 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 246196002458 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 246196002459 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196002460 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 246196002461 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 246196002462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196002463 Citrate transporter; Region: CitMHS; pfam03600 246196002464 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 246196002465 transmembrane helices; other site 246196002466 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 246196002467 FOG: CBS domain [General function prediction only]; Region: COG0517 246196002468 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 246196002469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196002470 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196002471 dimerization interface [polypeptide binding]; other site 246196002472 Histidine kinase; Region: HisKA_3; pfam07730 246196002473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196002474 ATP binding site [chemical binding]; other site 246196002475 Mg2+ binding site [ion binding]; other site 246196002476 G-X-G motif; other site 246196002477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196002478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002479 active site 246196002480 phosphorylation site [posttranslational modification] 246196002481 intermolecular recognition site; other site 246196002482 dimerization interface [polypeptide binding]; other site 246196002483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196002484 DNA binding residues [nucleotide binding] 246196002485 dimerization interface [polypeptide binding]; other site 246196002486 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196002487 2TM domain; Region: 2TM; pfam13239 246196002488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002489 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 246196002490 putative hydrophobic ligand binding site [chemical binding]; other site 246196002491 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 246196002492 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 246196002493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002494 Walker A motif; other site 246196002495 ATP binding site [chemical binding]; other site 246196002496 Walker B motif; other site 246196002497 arginine finger; other site 246196002498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196002499 Walker A motif; other site 246196002500 ATP binding site [chemical binding]; other site 246196002501 Walker B motif; other site 246196002502 arginine finger; other site 246196002503 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 246196002504 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 246196002505 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 246196002506 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 246196002507 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246196002508 dimer interface [polypeptide binding]; other site 246196002509 putative functional site; other site 246196002510 putative MPT binding site; other site 246196002511 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196002512 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 246196002513 putative NAD(P) binding site [chemical binding]; other site 246196002514 active site 246196002515 Bacterial PH domain; Region: bPH_2; cl01348 246196002516 Predicted membrane protein [Function unknown]; Region: COG3428 246196002517 Bacterial PH domain; Region: bPH_2; pfam03703 246196002518 Bacterial PH domain; Region: bPH_2; pfam03703 246196002519 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 246196002520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196002521 active site 246196002522 motif I; other site 246196002523 motif II; other site 246196002524 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 246196002525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196002526 ATP binding site [chemical binding]; other site 246196002527 putative Mg++ binding site [ion binding]; other site 246196002528 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196002529 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196002530 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196002531 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196002532 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 246196002533 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 246196002534 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196002535 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196002536 catalytic loop [active] 246196002537 iron binding site [ion binding]; other site 246196002538 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196002539 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196002540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196002541 DNA-binding site [nucleotide binding]; DNA binding site 246196002542 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196002543 putative sialic acid transporter; Provisional; Region: PRK03893 246196002544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002545 putative substrate translocation pore; other site 246196002546 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 246196002547 inhibitor site; inhibition site 246196002548 active site 246196002549 dimer interface [polypeptide binding]; other site 246196002550 catalytic residue [active] 246196002551 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 246196002552 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196002553 putative NAD(P) binding site [chemical binding]; other site 246196002554 active site 246196002555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002557 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 246196002558 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246196002559 ring oligomerisation interface [polypeptide binding]; other site 246196002560 ATP/Mg binding site [chemical binding]; other site 246196002561 stacking interactions; other site 246196002562 hinge regions; other site 246196002563 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196002564 putative active site [active] 246196002565 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196002566 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 246196002567 active site 246196002568 putative substrate binding pocket [chemical binding]; other site 246196002569 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 246196002570 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196002571 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196002572 active site 246196002573 ATP binding site [chemical binding]; other site 246196002574 substrate binding site [chemical binding]; other site 246196002575 activation loop (A-loop); other site 246196002576 Protein of unknown function (DUF664); Region: DUF664; pfam04978 246196002577 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 246196002578 active site 246196002579 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 246196002580 NAD(P) binding site [chemical binding]; other site 246196002581 catalytic residues [active] 246196002582 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 246196002583 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196002584 Zn2+ binding site [ion binding]; other site 246196002585 Mg2+ binding site [ion binding]; other site 246196002586 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 246196002587 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 246196002588 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 246196002589 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 246196002590 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196002591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196002592 DNA-binding site [nucleotide binding]; DNA binding site 246196002593 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196002594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002595 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196002596 putative substrate translocation pore; other site 246196002597 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 246196002598 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 246196002599 active site 246196002600 intersubunit interface [polypeptide binding]; other site 246196002601 zinc binding site [ion binding]; other site 246196002602 Na+ binding site [ion binding]; other site 246196002603 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 246196002604 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196002605 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 246196002606 NAD(P) binding site [chemical binding]; other site 246196002607 catalytic residues [active] 246196002608 Protein of unknown function (DUF779); Region: DUF779; pfam05610 246196002609 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246196002610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196002611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002612 S-adenosylmethionine binding site [chemical binding]; other site 246196002613 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 246196002614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196002615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196002616 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 246196002617 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196002618 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196002619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196002620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196002621 non-specific DNA binding site [nucleotide binding]; other site 246196002622 salt bridge; other site 246196002623 sequence-specific DNA binding site [nucleotide binding]; other site 246196002624 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 246196002625 Domain of unknown function (DUF955); Region: DUF955; pfam06114 246196002626 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 246196002627 Hemerythrin family; Region: Hemerythrin-like; cl15774 246196002628 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 246196002629 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246196002630 active site 246196002631 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196002632 active site 2 [active] 246196002633 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196002634 tetramer interface [polypeptide binding]; other site 246196002635 active site 246196002636 Mg2+/Mn2+ binding site [ion binding]; other site 246196002637 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 246196002638 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196002639 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196002640 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246196002641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002642 S-adenosylmethionine binding site [chemical binding]; other site 246196002643 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 246196002644 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196002646 non-specific DNA binding site [nucleotide binding]; other site 246196002647 salt bridge; other site 246196002648 sequence-specific DNA binding site [nucleotide binding]; other site 246196002649 Predicted membrane protein [Function unknown]; Region: COG2733 246196002650 Protein of unknown function (DUF445); Region: DUF445; pfam04286 246196002651 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196002652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196002653 non-specific DNA binding site [nucleotide binding]; other site 246196002654 salt bridge; other site 246196002655 sequence-specific DNA binding site [nucleotide binding]; other site 246196002656 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 246196002657 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 246196002658 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 246196002659 intersubunit interface [polypeptide binding]; other site 246196002660 active site 246196002661 catalytic residue [active] 246196002662 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 246196002663 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 246196002664 putative active site [active] 246196002665 catalytic triad [active] 246196002666 putative dimer interface [polypeptide binding]; other site 246196002667 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196002668 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 246196002669 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 246196002670 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 246196002671 FAD binding domain; Region: FAD_binding_4; pfam01565 246196002672 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 246196002673 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 246196002674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196002675 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 246196002676 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196002677 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196002678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002679 NAD(P) binding site [chemical binding]; other site 246196002680 active site 246196002681 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 246196002682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196002683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196002684 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 246196002685 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 246196002686 putative ADP-binding pocket [chemical binding]; other site 246196002687 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 246196002688 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196002689 catalytic core [active] 246196002690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196002691 dimer interface [polypeptide binding]; other site 246196002692 phosphorylation site [posttranslational modification] 246196002693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196002694 ATP binding site [chemical binding]; other site 246196002695 Mg2+ binding site [ion binding]; other site 246196002696 G-X-G motif; other site 246196002697 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196002698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002699 active site 246196002700 phosphorylation site [posttranslational modification] 246196002701 intermolecular recognition site; other site 246196002702 dimerization interface [polypeptide binding]; other site 246196002703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196002704 DNA binding site [nucleotide binding] 246196002705 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 246196002706 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 246196002707 Drosophila roughex protein; Region: Roughex; pfam06020 246196002708 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196002709 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196002710 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196002711 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196002712 active site 2 [active] 246196002713 active site 1 [active] 246196002714 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 246196002715 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 246196002716 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 246196002717 DNA binding domain, excisionase family; Region: excise; TIGR01764 246196002718 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196002719 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 246196002720 putative NAD(P) binding site [chemical binding]; other site 246196002721 active site 246196002722 putative substrate binding site [chemical binding]; other site 246196002723 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 246196002724 putative acyl-acceptor binding pocket; other site 246196002725 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196002726 active site 246196002727 catalytic site [active] 246196002728 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 246196002729 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 246196002730 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 246196002731 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 246196002732 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 246196002733 tRNA; other site 246196002734 putative tRNA binding site [nucleotide binding]; other site 246196002735 putative NADP binding site [chemical binding]; other site 246196002736 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 246196002737 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 246196002738 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 246196002739 domain interfaces; other site 246196002740 active site 246196002741 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 246196002742 active site 246196002743 homodimer interface [polypeptide binding]; other site 246196002744 SAM binding site [chemical binding]; other site 246196002745 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 246196002746 active site 246196002747 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 246196002748 dimer interface [polypeptide binding]; other site 246196002749 active site 246196002750 Schiff base residues; other site 246196002751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002753 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 246196002754 MspA; Region: MspA; pfam09203 246196002755 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196002756 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196002757 Cytochrome P450; Region: p450; cl12078 246196002758 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 246196002759 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196002760 inhibitor-cofactor binding pocket; inhibition site 246196002761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002762 catalytic residue [active] 246196002763 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196002764 catalytic core [active] 246196002765 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246196002766 catalytic residues [active] 246196002767 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 246196002768 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 246196002769 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 246196002770 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 246196002771 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196002772 P-loop; other site 246196002773 Magnesium ion binding site [ion binding]; other site 246196002774 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 246196002775 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196002776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196002777 catalytic residue [active] 246196002778 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 246196002779 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246196002780 Histidine kinase; Region: HisKA_3; pfam07730 246196002781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196002782 ATP binding site [chemical binding]; other site 246196002783 Mg2+ binding site [ion binding]; other site 246196002784 G-X-G motif; other site 246196002785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196002786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002787 active site 246196002788 phosphorylation site [posttranslational modification] 246196002789 intermolecular recognition site; other site 246196002790 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 246196002791 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196002792 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 246196002793 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 246196002794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196002795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002796 active site 246196002797 phosphorylation site [posttranslational modification] 246196002798 intermolecular recognition site; other site 246196002799 dimerization interface [polypeptide binding]; other site 246196002800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196002801 DNA binding residues [nucleotide binding] 246196002802 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 246196002803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002804 putative substrate translocation pore; other site 246196002805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002807 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 246196002808 putative active site [active] 246196002809 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 246196002810 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 246196002811 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196002812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196002813 NAD(P) binding site [chemical binding]; other site 246196002814 active site 246196002815 Nitronate monooxygenase; Region: NMO; pfam03060 246196002816 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196002817 FMN binding site [chemical binding]; other site 246196002818 substrate binding site [chemical binding]; other site 246196002819 putative catalytic residue [active] 246196002820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196002821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196002822 dimer interface [polypeptide binding]; other site 246196002823 phosphorylation site [posttranslational modification] 246196002824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196002825 ATP binding site [chemical binding]; other site 246196002826 Mg2+ binding site [ion binding]; other site 246196002827 G-X-G motif; other site 246196002828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196002829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196002830 active site 246196002831 phosphorylation site [posttranslational modification] 246196002832 intermolecular recognition site; other site 246196002833 dimerization interface [polypeptide binding]; other site 246196002834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196002835 DNA binding site [nucleotide binding] 246196002836 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246196002837 Ligand binding site; other site 246196002838 Putative Catalytic site; other site 246196002839 DXD motif; other site 246196002840 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 246196002841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002842 S-adenosylmethionine binding site [chemical binding]; other site 246196002843 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 246196002844 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 246196002845 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 246196002846 Moco binding site; other site 246196002847 metal coordination site [ion binding]; other site 246196002848 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 246196002849 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196002850 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196002851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196002852 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196002853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002854 S-adenosylmethionine binding site [chemical binding]; other site 246196002855 Phosphotransferase enzyme family; Region: APH; pfam01636 246196002856 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196002857 putative active site [active] 246196002858 putative substrate binding site [chemical binding]; other site 246196002859 ATP binding site [chemical binding]; other site 246196002860 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196002861 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 246196002862 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196002863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002865 short chain dehydrogenase; Provisional; Region: PRK05650 246196002866 short chain dehydrogenase; Provisional; Region: PRK07832 246196002867 NAD(P) binding site [chemical binding]; other site 246196002868 active site 246196002869 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 246196002870 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 246196002871 dimer interface [polypeptide binding]; other site 246196002872 active site 246196002873 Predicted ATPase [General function prediction only]; Region: COG4637 246196002874 AAA domain; Region: AAA_23; pfam13476 246196002875 Walker A/P-loop; other site 246196002876 ATP binding site [chemical binding]; other site 246196002877 ABC transporter signature motif; other site 246196002878 AAA domain; Region: AAA_21; pfam13304 246196002879 Walker B; other site 246196002880 D-loop; other site 246196002881 H-loop/switch region; other site 246196002882 DNA polymerase IV; Validated; Region: PRK03352 246196002883 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246196002884 active site 246196002885 DNA binding site [nucleotide binding] 246196002886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002888 Predicted flavoprotein [General function prediction only]; Region: COG0431 246196002889 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 246196002890 catalytic residues [active] 246196002891 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 246196002892 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 246196002893 Class I ribonucleotide reductase; Region: RNR_I; cd01679 246196002894 active site 246196002895 dimer interface [polypeptide binding]; other site 246196002896 catalytic residues [active] 246196002897 effector binding site; other site 246196002898 R2 peptide binding site; other site 246196002899 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 246196002900 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196002901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196002902 putative substrate translocation pore; other site 246196002903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 246196002904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196002905 Coenzyme A binding pocket [chemical binding]; other site 246196002906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002908 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196002909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196002910 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246196002911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196002912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196002913 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196002914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196002915 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196002916 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 246196002917 dimer interface [polypeptide binding]; other site 246196002918 putative radical transfer pathway; other site 246196002919 diiron center [ion binding]; other site 246196002920 tyrosyl radical; other site 246196002921 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196002922 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246196002923 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196002924 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 246196002925 putative NAD(P) binding site [chemical binding]; other site 246196002926 putative substrate binding site [chemical binding]; other site 246196002927 catalytic Zn binding site [ion binding]; other site 246196002928 structural Zn binding site [ion binding]; other site 246196002929 dimer interface [polypeptide binding]; other site 246196002930 YCII-related domain; Region: YCII; cl00999 246196002931 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196002932 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246196002933 intersubunit interface [polypeptide binding]; other site 246196002934 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 246196002935 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246196002936 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 246196002937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196002938 motif II; other site 246196002939 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196002940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196002941 DNA-binding site [nucleotide binding]; DNA binding site 246196002942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196002943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196002944 homodimer interface [polypeptide binding]; other site 246196002945 catalytic residue [active] 246196002946 Predicted membrane protein [Function unknown]; Region: COG2364 246196002947 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 246196002948 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 246196002949 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 246196002950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196002951 Walker A/P-loop; other site 246196002952 ATP binding site [chemical binding]; other site 246196002953 Q-loop/lid; other site 246196002954 ABC transporter signature motif; other site 246196002955 Walker B; other site 246196002956 D-loop; other site 246196002957 H-loop/switch region; other site 246196002958 NUDIX domain; Region: NUDIX; pfam00293 246196002959 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196002960 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196002961 substrate binding site [chemical binding]; other site 246196002962 oxyanion hole (OAH) forming residues; other site 246196002963 trimer interface [polypeptide binding]; other site 246196002964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196002965 S-adenosylmethionine binding site [chemical binding]; other site 246196002966 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 246196002967 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 246196002968 FOG: WD40-like repeat [Function unknown]; Region: COG1520 246196002969 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196002970 active site 246196002971 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 246196002972 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 246196002973 trimer interface [polypeptide binding]; other site 246196002974 active site 246196002975 substrate binding site [chemical binding]; other site 246196002976 CoA binding site [chemical binding]; other site 246196002977 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 246196002978 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 246196002979 homotetramer interface [polypeptide binding]; other site 246196002980 FMN binding site [chemical binding]; other site 246196002981 homodimer contacts [polypeptide binding]; other site 246196002982 putative active site [active] 246196002983 putative substrate binding site [chemical binding]; other site 246196002984 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196002985 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196002986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196002987 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196002988 Lsr2; Region: Lsr2; pfam11774 246196002989 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 246196002990 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 246196002991 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 246196002992 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196002993 acyl-activating enzyme (AAE) consensus motif; other site 246196002994 AMP binding site [chemical binding]; other site 246196002995 active site 246196002996 CoA binding site [chemical binding]; other site 246196002997 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 246196002998 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 246196002999 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 246196003000 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196003001 active site 246196003002 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196003003 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196003004 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196003005 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196003006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196003007 classical (c) SDRs; Region: SDR_c; cd05233 246196003008 NAD(P) binding site [chemical binding]; other site 246196003009 active site 246196003010 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196003011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196003012 NAD(P) binding site [chemical binding]; other site 246196003013 active site 246196003014 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 246196003015 oligomer interface [polypeptide binding]; other site 246196003016 putative active site [active] 246196003017 Mn binding site [ion binding]; other site 246196003018 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 246196003019 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 246196003020 active site 246196003021 catalytic site [active] 246196003022 Zn binding site [ion binding]; other site 246196003023 tetramer interface [polypeptide binding]; other site 246196003024 short chain dehydrogenase; Provisional; Region: PRK05866 246196003025 classical (c) SDRs; Region: SDR_c; cd05233 246196003026 NAD(P) binding site [chemical binding]; other site 246196003027 active site 246196003028 Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447 246196003029 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003030 substrate binding site [chemical binding]; other site 246196003031 oxyanion hole (OAH) forming residues; other site 246196003032 trimer interface [polypeptide binding]; other site 246196003033 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196003034 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 246196003035 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196003036 motif II; other site 246196003037 LamB/YcsF family; Region: LamB_YcsF; pfam03746 246196003038 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 246196003039 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196003040 iron-sulfur cluster [ion binding]; other site 246196003041 [2Fe-2S] cluster binding site [ion binding]; other site 246196003042 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196003043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196003044 DNA binding residues [nucleotide binding] 246196003045 dimerization interface [polypeptide binding]; other site 246196003046 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196003047 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 246196003048 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196003049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196003050 dimer interface [polypeptide binding]; other site 246196003051 conserved gate region; other site 246196003052 putative PBP binding loops; other site 246196003053 ABC-ATPase subunit interface; other site 246196003054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196003055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196003056 dimer interface [polypeptide binding]; other site 246196003057 conserved gate region; other site 246196003058 putative PBP binding loops; other site 246196003059 ABC-ATPase subunit interface; other site 246196003060 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196003061 Amidase; Region: Amidase; pfam01425 246196003062 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 246196003063 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 246196003064 dimer interface [polypeptide binding]; other site 246196003065 catalytic residues [active] 246196003066 UreF; Region: UreF; cl19817 246196003067 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 246196003068 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 246196003069 alpha-gamma subunit interface [polypeptide binding]; other site 246196003070 beta-gamma subunit interface [polypeptide binding]; other site 246196003071 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 246196003072 gamma-beta subunit interface [polypeptide binding]; other site 246196003073 alpha-beta subunit interface [polypeptide binding]; other site 246196003074 urease subunit alpha; Reviewed; Region: ureC; PRK13308 246196003075 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196003076 active site 246196003077 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246196003078 G1 box; other site 246196003079 GTP/Mg2+ binding site [chemical binding]; other site 246196003080 G2 box; other site 246196003081 Switch I region; other site 246196003082 G3 box; other site 246196003083 Switch II region; other site 246196003084 G4 box; other site 246196003085 G5 box; other site 246196003086 UreD urease accessory protein; Region: UreD; cl00530 246196003087 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246196003088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196003089 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196003090 acyl-CoA synthetase; Validated; Region: PRK06188 246196003091 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196003092 putative active site [active] 246196003093 putative CoA binding site [chemical binding]; other site 246196003094 putative AMP binding site [chemical binding]; other site 246196003095 YCII-related domain; Region: YCII; cl00999 246196003096 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196003097 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196003098 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 246196003099 active site 246196003100 O-succinylbenzoate synthase; Provisional; Region: PRK02901 246196003101 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 246196003102 active site 246196003103 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246196003104 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196003105 conserved cys residue [active] 246196003106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196003107 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 246196003108 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 246196003109 conserved cys residue [active] 246196003110 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196003111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196003112 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196003113 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 246196003114 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 246196003115 dimer interface [polypeptide binding]; other site 246196003116 tetramer interface [polypeptide binding]; other site 246196003117 PYR/PP interface [polypeptide binding]; other site 246196003118 TPP binding site [chemical binding]; other site 246196003119 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 246196003120 TPP-binding site; other site 246196003121 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 246196003122 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246196003123 Thioredoxin; Region: Thioredoxin_4; cl17273 246196003124 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 246196003125 catalytic residues [active] 246196003126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196003127 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 246196003128 aconitate hydratase; Validated; Region: PRK07229 246196003129 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246196003130 substrate binding site [chemical binding]; other site 246196003131 ligand binding site [chemical binding]; other site 246196003132 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 246196003133 substrate binding site [chemical binding]; other site 246196003134 short chain dehydrogenase; Provisional; Region: PRK08263 246196003135 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196003136 NADP binding site [chemical binding]; other site 246196003137 active site 246196003138 steroid binding site; other site 246196003139 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 246196003140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003141 S-adenosylmethionine binding site [chemical binding]; other site 246196003142 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196003143 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196003144 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196003145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196003146 DNA-binding site [nucleotide binding]; DNA binding site 246196003147 FCD domain; Region: FCD; pfam07729 246196003148 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196003149 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196003150 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 246196003151 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 246196003152 catalytic triad [active] 246196003153 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 246196003154 putative active site [active] 246196003155 catalytic triad [active] 246196003156 putative dimer interface [polypeptide binding]; other site 246196003157 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 246196003158 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 246196003159 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 246196003160 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 246196003161 Ferredoxin [Energy production and conversion]; Region: COG1146 246196003162 4Fe-4S binding domain; Region: Fer4; pfam00037 246196003163 Predicted transcriptional regulator [Transcription]; Region: COG2345 246196003164 dimerization interface [polypeptide binding]; other site 246196003165 putative DNA binding site [nucleotide binding]; other site 246196003166 Helix-turn-helix domain; Region: HTH_20; pfam12840 246196003167 putative Zn2+ binding site [ion binding]; other site 246196003168 Death Domain Superfamily of protein-protein interaction domains; Region: DD; cl14633 246196003169 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196003170 FAD dependent oxidoreductase; Region: DAO; pfam01266 246196003171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196003172 Joubert syndrome-associated; Region: Joubert; pfam15392 246196003173 TspO/MBR family; Region: TspO_MBR; pfam03073 246196003174 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246196003175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196003176 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246196003177 substrate binding pocket [chemical binding]; other site 246196003178 chain length determination region; other site 246196003179 substrate-Mg2+ binding site; other site 246196003180 catalytic residues [active] 246196003181 aspartate-rich region 1; other site 246196003182 active site lid residues [active] 246196003183 aspartate-rich region 2; other site 246196003184 heat shock protein HtpX; Provisional; Region: PRK03072 246196003185 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196003186 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196003187 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 246196003188 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196003189 NAD binding site [chemical binding]; other site 246196003190 catalytic Zn binding site [ion binding]; other site 246196003191 substrate binding site [chemical binding]; other site 246196003192 structural Zn binding site [ion binding]; other site 246196003193 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196003194 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196003195 non-specific DNA binding site [nucleotide binding]; other site 246196003196 salt bridge; other site 246196003197 sequence-specific DNA binding site [nucleotide binding]; other site 246196003198 Cupin domain; Region: Cupin_2; pfam07883 246196003199 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 246196003200 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 246196003201 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 246196003202 Permease; Region: Permease; pfam02405 246196003203 Permease; Region: Permease; pfam02405 246196003204 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196003205 mce related protein; Region: MCE; pfam02470 246196003206 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196003207 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196003208 mce related protein; Region: MCE; pfam02470 246196003209 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196003210 mce related protein; Region: MCE; pfam02470 246196003211 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196003212 mce related protein; Region: MCE; pfam02470 246196003213 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196003214 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196003215 mce related protein; Region: MCE; pfam02470 246196003216 Uncharacterized conserved protein (DUF2365); Region: DUF2365; pfam10157 246196003217 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196003218 mce related protein; Region: MCE; pfam02470 246196003219 Domain of unknown function (DUF697); Region: DUF697; cl12064 246196003220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 246196003221 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 246196003222 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 246196003223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196003224 non-specific DNA binding site [nucleotide binding]; other site 246196003225 salt bridge; other site 246196003226 sequence-specific DNA binding site [nucleotide binding]; other site 246196003227 Cupin domain; Region: Cupin_2; pfam07883 246196003228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003229 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196003230 putative substrate translocation pore; other site 246196003231 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 246196003232 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196003233 enoyl-CoA hydratase; Provisional; Region: PRK06494 246196003234 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003235 substrate binding site [chemical binding]; other site 246196003236 oxyanion hole (OAH) forming residues; other site 246196003237 trimer interface [polypeptide binding]; other site 246196003238 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 246196003239 inhibitor site; inhibition site 246196003240 active site 246196003241 dimer interface [polypeptide binding]; other site 246196003242 catalytic residue [active] 246196003243 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196003244 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 246196003245 putative NAD(P) binding site [chemical binding]; other site 246196003246 putative active site [active] 246196003247 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196003248 NAD(P) binding site [chemical binding]; other site 246196003249 catalytic residues [active] 246196003250 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196003251 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196003252 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196003253 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196003254 Walker A/P-loop; other site 246196003255 ATP binding site [chemical binding]; other site 246196003256 Q-loop/lid; other site 246196003257 ABC transporter signature motif; other site 246196003258 Walker B; other site 246196003259 D-loop; other site 246196003260 H-loop/switch region; other site 246196003261 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196003262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196003263 dimer interface [polypeptide binding]; other site 246196003264 conserved gate region; other site 246196003265 putative PBP binding loops; other site 246196003266 ABC-ATPase subunit interface; other site 246196003267 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196003268 active site 246196003269 non-prolyl cis peptide bond; other site 246196003270 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 246196003271 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196003272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196003273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003274 putative substrate translocation pore; other site 246196003275 Low molecular weight phosphatase family; Region: LMWPc; cd00115 246196003276 active site 246196003277 arsenical-resistance protein; Region: acr3; TIGR00832 246196003278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196003279 dimerization interface [polypeptide binding]; other site 246196003280 putative DNA binding site [nucleotide binding]; other site 246196003281 putative Zn2+ binding site [ion binding]; other site 246196003282 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 246196003283 putative metal binding site [ion binding]; other site 246196003284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196003285 dimerization interface [polypeptide binding]; other site 246196003286 putative DNA binding site [nucleotide binding]; other site 246196003287 putative Zn2+ binding site [ion binding]; other site 246196003288 PE-PPE domain; Region: PE-PPE; pfam08237 246196003289 sec-independent translocase; Provisional; Region: PRK00708 246196003290 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 246196003291 Na binding site [ion binding]; other site 246196003292 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 246196003293 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 246196003294 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 246196003295 urocanate hydratase; Provisional; Region: PRK05414 246196003296 allantoate amidohydrolase; Reviewed; Region: PRK09290 246196003297 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 246196003298 active site 246196003299 metal binding site [ion binding]; metal-binding site 246196003300 dimer interface [polypeptide binding]; other site 246196003301 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 246196003302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196003303 active site 246196003304 imidazolonepropionase; Provisional; Region: PRK14085 246196003305 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 246196003306 active site 246196003307 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 246196003308 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 246196003309 active sites [active] 246196003310 tetramer interface [polypeptide binding]; other site 246196003311 Cutinase; Region: Cutinase; pfam01083 246196003312 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246196003313 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196003314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196003315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196003316 putative DNA binding site [nucleotide binding]; other site 246196003317 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196003318 putative Zn2+ binding site [ion binding]; other site 246196003319 AsnC family; Region: AsnC_trans_reg; pfam01037 246196003320 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246196003321 transmembrane helices; other site 246196003322 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196003323 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 246196003324 active site 246196003325 putative substrate binding pocket [chemical binding]; other site 246196003326 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 246196003327 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 246196003328 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196003329 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196003330 active site 246196003331 ATP binding site [chemical binding]; other site 246196003332 substrate binding site [chemical binding]; other site 246196003333 activation loop (A-loop); other site 246196003334 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246196003335 Peptidase family M23; Region: Peptidase_M23; pfam01551 246196003336 TROVE domain; Region: TROVE; pfam05731 246196003337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196003338 ATP binding site [chemical binding]; other site 246196003339 putative Mg++ binding site [ion binding]; other site 246196003340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196003341 nucleotide binding region [chemical binding]; other site 246196003342 ATP-binding site [chemical binding]; other site 246196003343 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 246196003344 DNA binding residues [nucleotide binding] 246196003345 dimerization interface [polypeptide binding]; other site 246196003346 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196003347 substrate binding site [chemical binding]; other site 246196003348 activation loop (A-loop); other site 246196003349 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 246196003350 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196003351 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196003352 active site 246196003353 ATP binding site [chemical binding]; other site 246196003354 substrate binding site [chemical binding]; other site 246196003355 activation loop (A-loop); other site 246196003356 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196003357 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196003358 substrate binding pocket [chemical binding]; other site 246196003359 membrane-bound complex binding site; other site 246196003360 hinge residues; other site 246196003361 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196003362 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 246196003363 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246196003364 dimer interface [polypeptide binding]; other site 246196003365 active site 246196003366 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246196003367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003368 S-adenosylmethionine binding site [chemical binding]; other site 246196003369 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246196003370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196003371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003372 S-adenosylmethionine binding site [chemical binding]; other site 246196003373 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 246196003374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196003375 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 246196003376 active site 246196003377 LabA_like proteins; Region: LabA_like; cd06167 246196003378 putative metal binding site [ion binding]; other site 246196003379 Uncharacterized conserved protein [Function unknown]; Region: COG1432 246196003380 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 246196003381 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 246196003382 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196003383 putative di-iron ligands [ion binding]; other site 246196003384 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196003385 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 246196003386 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 246196003387 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 246196003388 catalytic residues [active] 246196003389 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 246196003390 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 246196003391 putative ligand binding site [chemical binding]; other site 246196003392 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246196003393 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246196003394 Walker A/P-loop; other site 246196003395 ATP binding site [chemical binding]; other site 246196003396 Q-loop/lid; other site 246196003397 ABC transporter signature motif; other site 246196003398 Walker B; other site 246196003399 D-loop; other site 246196003400 H-loop/switch region; other site 246196003401 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196003402 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246196003403 Walker A/P-loop; other site 246196003404 ATP binding site [chemical binding]; other site 246196003405 Q-loop/lid; other site 246196003406 ABC transporter signature motif; other site 246196003407 Walker B; other site 246196003408 D-loop; other site 246196003409 H-loop/switch region; other site 246196003410 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246196003411 TM-ABC transporter signature motif; other site 246196003412 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246196003413 TM-ABC transporter signature motif; other site 246196003414 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 246196003415 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196003416 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246196003417 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 246196003418 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196003419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196003420 DNA-binding site [nucleotide binding]; DNA binding site 246196003421 UTRA domain; Region: UTRA; pfam07702 246196003422 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196003423 Sulfatase; Region: Sulfatase; pfam00884 246196003424 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 246196003425 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 246196003426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196003427 ATP binding site [chemical binding]; other site 246196003428 Mg2+ binding site [ion binding]; other site 246196003429 G-X-G motif; other site 246196003430 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 246196003431 anchoring element; other site 246196003432 dimer interface [polypeptide binding]; other site 246196003433 ATP binding site [chemical binding]; other site 246196003434 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 246196003435 active site 246196003436 metal binding site [ion binding]; metal-binding site 246196003437 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246196003438 Domain of unknown function (DUF202); Region: DUF202; pfam02656 246196003439 Domain of unknown function (DUF202); Region: DUF202; cl09954 246196003440 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196003441 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196003442 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196003443 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196003444 Walker A/P-loop; other site 246196003445 ATP binding site [chemical binding]; other site 246196003446 Q-loop/lid; other site 246196003447 ABC transporter signature motif; other site 246196003448 Walker B; other site 246196003449 D-loop; other site 246196003450 H-loop/switch region; other site 246196003451 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 246196003452 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246196003453 Sulfate transporter family; Region: Sulfate_transp; pfam00916 246196003454 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 246196003455 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 246196003456 PASTA domain; Region: PASTA; pfam03793 246196003457 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246196003458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196003459 ATP binding site [chemical binding]; other site 246196003460 putative Mg++ binding site [ion binding]; other site 246196003461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196003462 nucleotide binding region [chemical binding]; other site 246196003463 ATP-binding site [chemical binding]; other site 246196003464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196003465 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196003466 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 246196003467 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196003468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 246196003469 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 246196003470 PLD-like domain; Region: PLDc_2; pfam13091 246196003471 putative homodimer interface [polypeptide binding]; other site 246196003472 putative active site [active] 246196003473 catalytic site [active] 246196003474 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 246196003475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196003476 catalytic residue [active] 246196003477 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 246196003478 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 246196003479 Active Sites [active] 246196003480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196003481 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 246196003482 putative transposase OrfB; Reviewed; Region: PHA02517 246196003483 HTH-like domain; Region: HTH_21; pfam13276 246196003484 Integrase core domain; Region: rve; pfam00665 246196003485 Integrase core domain; Region: rve_3; cl15866 246196003486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196003487 Transposase; Region: HTH_Tnp_1; cl17663 246196003488 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196003489 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 246196003490 Part of AAA domain; Region: AAA_19; pfam13245 246196003491 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 246196003492 AAA domain; Region: AAA_12; pfam13087 246196003493 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 246196003494 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246196003495 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 246196003496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196003497 Walker A motif; other site 246196003498 ATP binding site [chemical binding]; other site 246196003499 putative Mg++ binding site [ion binding]; other site 246196003500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196003501 ATP-binding site [chemical binding]; other site 246196003502 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 246196003503 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 246196003504 Part of AAA domain; Region: AAA_19; pfam13245 246196003505 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 246196003506 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196003507 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196003508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196003509 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196003510 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 246196003511 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 246196003512 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 246196003513 SIR2-like domain; Region: SIR2_2; pfam13289 246196003514 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246196003515 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246196003516 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 246196003517 nudix motif; other site 246196003518 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 246196003519 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 246196003520 active site 246196003521 metal binding site [ion binding]; metal-binding site 246196003522 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 246196003523 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 246196003524 active site 246196003525 catalytic residues [active] 246196003526 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196003527 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196003528 Strictosidine synthase; Region: Str_synth; cl19733 246196003529 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196003530 active site 246196003531 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 246196003532 Fic/DOC family; Region: Fic; cl00960 246196003533 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 246196003534 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 246196003535 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 246196003536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 246196003537 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 246196003538 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 246196003539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 246196003540 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 246196003541 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 246196003542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 246196003543 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 246196003544 putative active site [active] 246196003545 SEC-C motif; Region: SEC-C; pfam02810 246196003546 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196003547 Sulfatase; Region: Sulfatase; pfam00884 246196003548 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 246196003549 putative hydrophobic ligand binding site [chemical binding]; other site 246196003550 protein interface [polypeptide binding]; other site 246196003551 gate; other site 246196003552 Nuclease-related domain; Region: NERD; pfam08378 246196003553 AAA ATPase domain; Region: AAA_16; pfam13191 246196003554 Part of AAA domain; Region: AAA_19; pfam13245 246196003555 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 246196003556 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 246196003557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196003558 sequence-specific DNA binding site [nucleotide binding]; other site 246196003559 salt bridge; other site 246196003560 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 246196003561 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196003562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196003563 catalytic loop [active] 246196003564 iron binding site [ion binding]; other site 246196003565 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196003566 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196003567 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196003568 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196003569 FAD binding domain; Region: FAD_binding_4; cl19922 246196003570 Sulfate transporter family; Region: Sulfate_transp; cl19250 246196003571 xanthine permease; Region: pbuX; TIGR03173 246196003572 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 246196003573 putative OHCU decarboxylase; Provisional; Region: PRK13798 246196003574 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 246196003575 active site 246196003576 homotetramer interface [polypeptide binding]; other site 246196003577 urate oxidase; Region: urate_oxi; TIGR03383 246196003578 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 246196003579 active site 246196003580 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 246196003581 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 246196003582 active site 246196003583 putative substrate binding pocket [chemical binding]; other site 246196003584 guanine deaminase; Provisional; Region: PRK09228 246196003585 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196003586 active site 246196003587 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196003588 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196003589 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196003590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196003591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 246196003592 DNA binding residues [nucleotide binding] 246196003593 dimerization interface [polypeptide binding]; other site 246196003594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196003595 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196003596 non-specific DNA binding site [nucleotide binding]; other site 246196003597 salt bridge; other site 246196003598 sequence-specific DNA binding site [nucleotide binding]; other site 246196003599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196003600 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196003601 active site 246196003602 catalytic tetrad [active] 246196003603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003605 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 246196003606 NAD(P) binding site [chemical binding]; other site 246196003607 catalytic residues [active] 246196003608 EthD domain; Region: EthD; cl17553 246196003609 Predicted acyl esterases [General function prediction only]; Region: COG2936 246196003610 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 246196003611 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196003612 OPT oligopeptide transporter protein; Region: OPT; cl14607 246196003613 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 246196003614 SdiA-regulated; Region: SdiA-regulated; cl19046 246196003615 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 246196003616 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246196003617 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246196003618 SseB protein N-terminal domain; Region: SseB; pfam07179 246196003619 SseB protein N-terminal domain; Region: SseB; pfam07179 246196003620 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 246196003621 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 246196003622 G1 box; other site 246196003623 putative GEF interaction site [polypeptide binding]; other site 246196003624 GTP/Mg2+ binding site [chemical binding]; other site 246196003625 Switch I region; other site 246196003626 G2 box; other site 246196003627 G3 box; other site 246196003628 Switch II region; other site 246196003629 G4 box; other site 246196003630 G5 box; other site 246196003631 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 246196003632 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196003633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196003634 DNA-binding site [nucleotide binding]; DNA binding site 246196003635 FCD domain; Region: FCD; pfam07729 246196003636 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 246196003637 active site 246196003638 catalytic site [active] 246196003639 Zn binding site [ion binding]; other site 246196003640 tetramer interface [polypeptide binding]; other site 246196003641 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246196003642 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196003643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003644 D-galactonate transporter; Region: 2A0114; TIGR00893 246196003645 putative substrate translocation pore; other site 246196003646 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196003647 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196003648 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 246196003649 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 246196003650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196003651 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196003652 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 246196003653 AAA domain; Region: AAA_30; pfam13604 246196003654 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 246196003655 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 246196003656 Part of AAA domain; Region: AAA_19; pfam13245 246196003657 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246196003658 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 246196003659 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 246196003660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003661 putative substrate translocation pore; other site 246196003662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196003663 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196003664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196003665 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196003666 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003667 substrate binding site [chemical binding]; other site 246196003668 oxyanion hole (OAH) forming residues; other site 246196003669 trimer interface [polypeptide binding]; other site 246196003670 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 246196003671 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246196003672 Transcriptional regulator; Region: Rrf2; cl17282 246196003673 Rrf2 family protein; Region: rrf2_super; TIGR00738 246196003674 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 246196003675 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 246196003676 heme-binding site [chemical binding]; other site 246196003677 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 246196003678 FAD binding pocket [chemical binding]; other site 246196003679 FAD binding motif [chemical binding]; other site 246196003680 phosphate binding motif [ion binding]; other site 246196003681 beta-alpha-beta structure motif; other site 246196003682 NAD binding pocket [chemical binding]; other site 246196003683 Heme binding pocket [chemical binding]; other site 246196003684 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 246196003685 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196003686 active site 246196003687 catalytic site [active] 246196003688 (3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional; Region: PRK13693 246196003689 active site 2 [active] 246196003690 active site 1 [active] 246196003691 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196003692 active site 246196003693 catalytic site [active] 246196003694 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 246196003695 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 246196003696 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 246196003697 putative homodimer interface [polypeptide binding]; other site 246196003698 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 246196003699 heterodimer interface [polypeptide binding]; other site 246196003700 homodimer interface [polypeptide binding]; other site 246196003701 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 246196003702 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 246196003703 23S rRNA interface [nucleotide binding]; other site 246196003704 L7/L12 interface [polypeptide binding]; other site 246196003705 putative thiostrepton binding site; other site 246196003706 L25 interface [polypeptide binding]; other site 246196003707 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 246196003708 mRNA/rRNA interface [nucleotide binding]; other site 246196003709 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 246196003710 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196003711 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196003712 DNA binding residues [nucleotide binding] 246196003713 YCII-related domain; Region: YCII; cl00999 246196003714 YCII-related domain; Region: YCII; cl00999 246196003715 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246196003716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003717 S-adenosylmethionine binding site [chemical binding]; other site 246196003718 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246196003719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196003720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196003721 S-adenosylmethionine binding site [chemical binding]; other site 246196003722 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196003723 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196003724 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246196003725 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196003726 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 246196003727 active site 246196003728 ATP binding site [chemical binding]; other site 246196003729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003731 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 246196003732 Protein of unknown function (DUF664); Region: DUF664; pfam04978 246196003733 DinB superfamily; Region: DinB_2; pfam12867 246196003734 Predicted transcriptional regulator [Transcription]; Region: COG2378 246196003735 HTH domain; Region: HTH_11; pfam08279 246196003736 WYL domain; Region: WYL; pfam13280 246196003737 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 246196003738 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246196003739 putative catalytic site [active] 246196003740 putative metal binding site [ion binding]; other site 246196003741 putative phosphate binding site [ion binding]; other site 246196003742 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 246196003743 active site 246196003744 catalytic site [active] 246196003745 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 246196003746 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 246196003747 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 246196003748 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 246196003749 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196003750 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196003751 nucleotide binding site [chemical binding]; other site 246196003752 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 246196003753 23S rRNA interface [nucleotide binding]; other site 246196003754 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 246196003755 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 246196003756 core dimer interface [polypeptide binding]; other site 246196003757 peripheral dimer interface [polypeptide binding]; other site 246196003758 L10 interface [polypeptide binding]; other site 246196003759 L11 interface [polypeptide binding]; other site 246196003760 putative EF-Tu interaction site [polypeptide binding]; other site 246196003761 putative EF-G interaction site [polypeptide binding]; other site 246196003762 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 246196003763 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 246196003764 Walker A/P-loop; other site 246196003765 ATP binding site [chemical binding]; other site 246196003766 Q-loop/lid; other site 246196003767 ABC transporter signature motif; other site 246196003768 Walker B; other site 246196003769 D-loop; other site 246196003770 H-loop/switch region; other site 246196003771 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 246196003772 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 246196003773 RPB12 interaction site [polypeptide binding]; other site 246196003774 RPB1 interaction site [polypeptide binding]; other site 246196003775 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 246196003776 RPB10 interaction site [polypeptide binding]; other site 246196003777 RPB11 interaction site [polypeptide binding]; other site 246196003778 RPB3 interaction site [polypeptide binding]; other site 246196003779 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 246196003780 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 246196003781 beta and beta' interface [polypeptide binding]; other site 246196003782 beta' and sigma factor interface [polypeptide binding]; other site 246196003783 Zn-binding [ion binding]; other site 246196003784 active site region [active] 246196003785 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 246196003786 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 246196003787 catalytic site [active] 246196003788 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 246196003789 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 246196003790 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 246196003791 G-loop; other site 246196003792 DNA binding site [nucleotide binding] 246196003793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196003794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196003795 DNA binding site [nucleotide binding] 246196003796 domain linker motif; other site 246196003797 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196003798 ligand binding site [chemical binding]; other site 246196003799 dimerization interface [polypeptide binding]; other site 246196003800 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196003801 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 246196003802 putative NAD(P) binding site [chemical binding]; other site 246196003803 catalytic Zn binding site [ion binding]; other site 246196003804 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 246196003805 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 246196003806 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196003807 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196003808 Walker A/P-loop; other site 246196003809 ATP binding site [chemical binding]; other site 246196003810 Q-loop/lid; other site 246196003811 ABC transporter signature motif; other site 246196003812 Walker B; other site 246196003813 D-loop; other site 246196003814 H-loop/switch region; other site 246196003815 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196003816 TM-ABC transporter signature motif; other site 246196003817 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196003818 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 246196003819 putative ligand binding site [chemical binding]; other site 246196003820 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 246196003821 intersubunit interface [polypeptide binding]; other site 246196003822 active site 246196003823 zinc binding site [ion binding]; other site 246196003824 Na+ binding site [ion binding]; other site 246196003825 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196003826 nucleotide binding site [chemical binding]; other site 246196003827 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196003828 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 246196003829 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196003830 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 246196003831 putative substrate binding site [chemical binding]; other site 246196003832 putative ATP binding site [chemical binding]; other site 246196003833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246196003834 Predicted dehydrogenase [General function prediction only]; Region: COG0579 246196003835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003837 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196003838 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196003839 MMPL family; Region: MMPL; pfam03176 246196003840 MMPL family; Region: MMPL; pfam03176 246196003841 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 246196003842 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 246196003843 AP (apurinic/apyrimidinic) site pocket; other site 246196003844 DNA interaction; other site 246196003845 Metal-binding active site; metal-binding site 246196003846 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 246196003847 active site 246196003848 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 246196003849 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 246196003850 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196003851 active site 246196003852 enoyl-CoA hydratase; Provisional; Region: PRK08272 246196003853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003854 substrate binding site [chemical binding]; other site 246196003855 oxyanion hole (OAH) forming residues; other site 246196003856 trimer interface [polypeptide binding]; other site 246196003857 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 246196003858 PaaX-like protein; Region: PaaX; pfam07848 246196003859 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 246196003860 enoyl-CoA hydratase; Provisional; Region: PRK08259 246196003861 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196003862 substrate binding site [chemical binding]; other site 246196003863 oxyanion hole (OAH) forming residues; other site 246196003864 trimer interface [polypeptide binding]; other site 246196003865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196003866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196003867 LysR substrate binding domain; Region: LysR_substrate; pfam03466 246196003868 dimerization interface [polypeptide binding]; other site 246196003869 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 246196003870 putative active site [active] 246196003871 metal binding site [ion binding]; metal-binding site 246196003872 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 246196003873 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 246196003874 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196003875 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196003876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003878 WHG domain; Region: WHG; pfam13305 246196003879 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 246196003880 S17 interaction site [polypeptide binding]; other site 246196003881 S8 interaction site; other site 246196003882 16S rRNA interaction site [nucleotide binding]; other site 246196003883 streptomycin interaction site [chemical binding]; other site 246196003884 23S rRNA interaction site [nucleotide binding]; other site 246196003885 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 246196003886 30S ribosomal protein S7; Validated; Region: PRK05302 246196003887 elongation factor Tu; Reviewed; Region: PRK00049 246196003888 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 246196003889 G1 box; other site 246196003890 GEF interaction site [polypeptide binding]; other site 246196003891 GTP/Mg2+ binding site [chemical binding]; other site 246196003892 Switch I region; other site 246196003893 G2 box; other site 246196003894 G3 box; other site 246196003895 Switch II region; other site 246196003896 G4 box; other site 246196003897 G5 box; other site 246196003898 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 246196003899 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 246196003900 Antibiotic Binding Site [chemical binding]; other site 246196003901 Cutinase; Region: Cutinase; pfam01083 246196003902 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196003903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196003904 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196003905 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196003906 Short C-terminal domain; Region: SHOCT; pfam09851 246196003907 arginine deiminase; Provisional; Region: PRK01388 246196003908 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196003909 classical (c) SDRs; Region: SDR_c; cd05233 246196003910 NAD(P) binding site [chemical binding]; other site 246196003911 active site 246196003912 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196003913 Ligand Binding Site [chemical binding]; other site 246196003914 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196003915 Ligand Binding Site [chemical binding]; other site 246196003916 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196003917 amino acid transporter; Region: 2A0306; TIGR00909 246196003918 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196003919 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196003920 inhibitor-cofactor binding pocket; inhibition site 246196003921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196003922 catalytic residue [active] 246196003923 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 246196003924 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196003925 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 246196003926 putative DNA binding site [nucleotide binding]; other site 246196003927 putative Zn2+ binding site [ion binding]; other site 246196003928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 246196003929 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196003930 Reductase C-terminal; Region: Reductase_C; pfam14759 246196003931 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 246196003932 putative dimer interface [polypeptide binding]; other site 246196003933 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196003934 active site 246196003935 metal binding site [ion binding]; metal-binding site 246196003936 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246196003937 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246196003938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196003939 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196003940 DNA binding residues [nucleotide binding] 246196003941 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 246196003942 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 246196003943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003944 mycofactocin precursor; Region: mycofactocin; TIGR03969 246196003945 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 246196003946 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 246196003947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196003948 FeS/SAM binding site; other site 246196003949 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246196003950 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 246196003951 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 246196003952 active site 246196003953 substrate binding site [chemical binding]; other site 246196003954 FMN binding site [chemical binding]; other site 246196003955 putative catalytic residues [active] 246196003956 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 246196003957 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 246196003958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196003959 active site 246196003960 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 246196003961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196003962 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196003963 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 246196003964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196003965 putative substrate translocation pore; other site 246196003966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196003967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196003968 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196003969 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196003970 Carboxylesterase family; Region: COesterase; pfam00135 246196003971 substrate binding pocket [chemical binding]; other site 246196003972 catalytic triad [active] 246196003973 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196003974 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196003975 CoenzymeA binding site [chemical binding]; other site 246196003976 subunit interaction site [polypeptide binding]; other site 246196003977 PHB binding site; other site 246196003978 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 246196003979 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 246196003980 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 246196003981 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 246196003982 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 246196003983 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 246196003984 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 246196003985 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 246196003986 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 246196003987 putative translocon binding site; other site 246196003988 protein-rRNA interface [nucleotide binding]; other site 246196003989 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 246196003990 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 246196003991 G-X-X-G motif; other site 246196003992 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 246196003993 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 246196003994 23S rRNA interface [nucleotide binding]; other site 246196003995 5S rRNA interface [nucleotide binding]; other site 246196003996 putative antibiotic binding site [chemical binding]; other site 246196003997 L25 interface [polypeptide binding]; other site 246196003998 L27 interface [polypeptide binding]; other site 246196003999 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 246196004000 putative translocon interaction site; other site 246196004001 23S rRNA interface [nucleotide binding]; other site 246196004002 signal recognition particle (SRP54) interaction site; other site 246196004003 L23 interface [polypeptide binding]; other site 246196004004 trigger factor interaction site; other site 246196004005 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 246196004006 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246196004007 nudix motif; other site 246196004008 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 246196004009 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196004010 DNA binding residues [nucleotide binding] 246196004011 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 246196004012 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246196004013 Sulfate transporter family; Region: Sulfate_transp; pfam00916 246196004014 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 246196004015 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246196004016 Sulfatase; Region: Sulfatase; pfam00884 246196004017 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 246196004018 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246196004019 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 246196004020 flagellar MS-ring protein; Reviewed; Region: fliF; PRK12800 246196004021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196004022 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196004023 putative substrate translocation pore; other site 246196004024 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 246196004025 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196004026 Domain of unknown function (DUF336); Region: DUF336; cl01249 246196004027 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 246196004028 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 246196004029 iron-sulfur cluster [ion binding]; other site 246196004030 [2Fe-2S] cluster binding site [ion binding]; other site 246196004031 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 246196004032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004033 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196004034 Reductase C-terminal; Region: Reductase_C; pfam14759 246196004035 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196004036 NAD(P) binding site [chemical binding]; other site 246196004037 catalytic residues [active] 246196004038 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 246196004039 [2Fe-2S] cluster binding site [ion binding]; other site 246196004040 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 246196004041 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246196004042 homotrimer interaction site [polypeptide binding]; other site 246196004043 putative active site [active] 246196004044 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 246196004045 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 246196004046 RNA binding site [nucleotide binding]; other site 246196004047 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 246196004048 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 246196004049 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 246196004050 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 246196004051 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 246196004052 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 246196004053 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 246196004054 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 246196004055 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 246196004056 5S rRNA interface [nucleotide binding]; other site 246196004057 L27 interface [polypeptide binding]; other site 246196004058 23S rRNA interface [nucleotide binding]; other site 246196004059 L5 interface [polypeptide binding]; other site 246196004060 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 246196004061 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 246196004062 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 246196004063 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 246196004064 23S rRNA binding site [nucleotide binding]; other site 246196004065 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 246196004066 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196004067 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 246196004068 tandem repeat interface [polypeptide binding]; other site 246196004069 oligomer interface [polypeptide binding]; other site 246196004070 active site residues [active] 246196004071 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 246196004072 tandem repeat interface [polypeptide binding]; other site 246196004073 oligomer interface [polypeptide binding]; other site 246196004074 active site residues [active] 246196004075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196004076 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196004077 putative substrate translocation pore; other site 246196004078 LysE type translocator; Region: LysE; cl00565 246196004079 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004080 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004081 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004082 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196004083 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 246196004084 SecY translocase; Region: SecY; pfam00344 246196004085 adenylate kinase; Reviewed; Region: adk; PRK00279 246196004086 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 246196004087 AMP-binding site [chemical binding]; other site 246196004088 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 246196004089 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246196004090 active site 246196004091 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 246196004092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004094 DNA binding residues [nucleotide binding] 246196004095 Putative zinc-finger; Region: zf-HC2; pfam13490 246196004096 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 246196004097 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196004098 PYR/PP interface [polypeptide binding]; other site 246196004099 dimer interface [polypeptide binding]; other site 246196004100 TPP binding site [chemical binding]; other site 246196004101 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 246196004102 TPP-binding site [chemical binding]; other site 246196004103 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 246196004104 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246196004105 active site 246196004106 putative aminotransferase; Provisional; Region: PRK03321 246196004107 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196004108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004109 homodimer interface [polypeptide binding]; other site 246196004110 catalytic residue [active] 246196004111 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196004112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196004113 putative DNA binding site [nucleotide binding]; other site 246196004114 putative Zn2+ binding site [ion binding]; other site 246196004115 GAF domain; Region: GAF; pfam01590 246196004116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196004117 Histidine kinase; Region: HisKA_3; pfam07730 246196004118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196004119 ATP binding site [chemical binding]; other site 246196004120 Mg2+ binding site [ion binding]; other site 246196004121 G-X-G motif; other site 246196004122 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196004123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196004124 active site 246196004125 phosphorylation site [posttranslational modification] 246196004126 intermolecular recognition site; other site 246196004127 dimerization interface [polypeptide binding]; other site 246196004128 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196004129 DNA binding residues [nucleotide binding] 246196004130 dimerization interface [polypeptide binding]; other site 246196004131 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 246196004132 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 246196004133 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196004134 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 246196004135 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196004136 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196004137 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 246196004138 substrate binding pocket [chemical binding]; other site 246196004139 FAD binding site [chemical binding]; other site 246196004140 catalytic base [active] 246196004141 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 246196004142 tetrameric interface [polypeptide binding]; other site 246196004143 NAD binding site [chemical binding]; other site 246196004144 catalytic residues [active] 246196004145 hypothetical protein; Provisional; Region: PRK06184 246196004146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004149 Leucine carboxyl methyltransferase; Region: LCM; cl01306 246196004150 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196004151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196004152 Walker A/P-loop; other site 246196004153 ATP binding site [chemical binding]; other site 246196004154 Q-loop/lid; other site 246196004155 ABC transporter signature motif; other site 246196004156 Walker B; other site 246196004157 D-loop; other site 246196004158 H-loop/switch region; other site 246196004159 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 246196004160 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 246196004161 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 246196004162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004163 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 246196004164 homodimer interface [polypeptide binding]; other site 246196004165 homotetramer interface [polypeptide binding]; other site 246196004166 active site pocket [active] 246196004167 cleavage site 246196004168 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196004169 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196004170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004172 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 246196004173 FMN binding site [chemical binding]; other site 246196004174 dimer interface [polypeptide binding]; other site 246196004175 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 246196004176 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 246196004177 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 246196004178 NAD binding site [chemical binding]; other site 246196004179 substrate binding site [chemical binding]; other site 246196004180 homodimer interface [polypeptide binding]; other site 246196004181 active site 246196004182 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196004183 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196004184 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196004185 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196004186 ligand binding site [chemical binding]; other site 246196004187 flexible hinge region; other site 246196004188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196004189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196004190 ATP binding site [chemical binding]; other site 246196004191 Mg2+ binding site [ion binding]; other site 246196004192 G-X-G motif; other site 246196004193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196004194 active site 246196004195 phosphorylation site [posttranslational modification] 246196004196 intermolecular recognition site; other site 246196004197 dimerization interface [polypeptide binding]; other site 246196004198 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 246196004199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 246196004201 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 246196004202 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 246196004203 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 246196004204 rRNA binding site [nucleotide binding]; other site 246196004205 predicted 30S ribosome binding site; other site 246196004206 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 246196004207 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 246196004208 30S ribosomal protein S11; Validated; Region: PRK05309 246196004209 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 246196004210 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 246196004211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196004212 RNA binding surface [nucleotide binding]; other site 246196004213 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 246196004214 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 246196004215 alphaNTD homodimer interface [polypeptide binding]; other site 246196004216 alphaNTD - beta interaction site [polypeptide binding]; other site 246196004217 alphaNTD - beta' interaction site [polypeptide binding]; other site 246196004218 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 246196004219 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 246196004220 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 246196004221 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 246196004222 dimerization interface 3.5A [polypeptide binding]; other site 246196004223 active site 246196004224 Cutinase; Region: Cutinase; pfam01083 246196004225 Cutinase; Region: Cutinase; pfam01083 246196004226 Cutinase; Region: Cutinase; pfam01083 246196004227 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 246196004228 EamA-like transporter family; Region: EamA; pfam00892 246196004229 EamA-like transporter family; Region: EamA; pfam00892 246196004230 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196004231 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196004232 Uncharacterized conserved protein [Function unknown]; Region: COG1359 246196004233 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 246196004234 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 246196004235 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 246196004236 active site 246196004237 catalytic residues [active] 246196004238 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 246196004239 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 246196004240 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196004241 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 246196004242 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196004243 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196004244 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 246196004245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 246196004246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 246196004247 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 246196004248 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246196004249 ATP binding site [chemical binding]; other site 246196004250 Mg++ binding site [ion binding]; other site 246196004251 motif III; other site 246196004252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196004253 nucleotide binding region [chemical binding]; other site 246196004254 ATP-binding site [chemical binding]; other site 246196004255 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 246196004256 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 246196004257 NAD(P) binding site [chemical binding]; other site 246196004258 catalytic residues [active] 246196004259 Domain of unknown function (DUF336); Region: DUF336; pfam03928 246196004260 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 246196004261 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 246196004262 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 246196004263 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 246196004264 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 246196004265 alpha-beta subunit interface [polypeptide binding]; other site 246196004266 alpha-gamma subunit interface [polypeptide binding]; other site 246196004267 active site 246196004268 substrate and K+ binding site; other site 246196004269 K+ binding site [ion binding]; other site 246196004270 cobalamin binding site [chemical binding]; other site 246196004271 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 246196004272 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 246196004273 ethanolamine permease; Region: 2A0305; TIGR00908 246196004274 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196004275 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 246196004276 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 246196004277 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 246196004278 23S rRNA interface [nucleotide binding]; other site 246196004279 L3 interface [polypeptide binding]; other site 246196004280 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 246196004281 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 246196004282 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 246196004283 active site 246196004284 substrate binding site [chemical binding]; other site 246196004285 metal binding site [ion binding]; metal-binding site 246196004286 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196004287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196004288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196004289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196004290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196004291 short chain dehydrogenase; Provisional; Region: PRK07041 246196004292 NAD(P) binding site [chemical binding]; other site 246196004293 active site 246196004294 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 246196004295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004297 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246196004298 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196004299 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196004300 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246196004301 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246196004302 glutaminase active site [active] 246196004303 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196004304 dimer interface [polypeptide binding]; other site 246196004305 active site 246196004306 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246196004307 dimer interface [polypeptide binding]; other site 246196004308 active site 246196004309 PGAP1-like protein; Region: PGAP1; pfam07819 246196004310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196004311 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246196004312 EamA-like transporter family; Region: EamA; pfam00892 246196004313 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196004314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196004315 DNA-binding site [nucleotide binding]; DNA binding site 246196004316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196004317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004318 homodimer interface [polypeptide binding]; other site 246196004319 catalytic residue [active] 246196004320 Uncharacterized conserved protein [Function unknown]; Region: COG0062 246196004321 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 246196004322 putative substrate binding site [chemical binding]; other site 246196004323 putative ATP binding site [chemical binding]; other site 246196004324 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 246196004325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004326 catalytic residue [active] 246196004327 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 246196004328 alanine racemase; Reviewed; Region: alr; PRK00053 246196004329 active site 246196004330 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196004331 dimer interface [polypeptide binding]; other site 246196004332 substrate binding site [chemical binding]; other site 246196004333 catalytic residues [active] 246196004334 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196004335 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196004336 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196004337 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196004338 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 246196004339 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 246196004340 Glycoprotease family; Region: Peptidase_M22; pfam00814 246196004341 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 246196004342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196004343 Coenzyme A binding pocket [chemical binding]; other site 246196004344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196004345 UGMP family protein; Validated; Region: PRK09604 246196004346 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 246196004347 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 246196004348 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 246196004349 oligomerisation interface [polypeptide binding]; other site 246196004350 mobile loop; other site 246196004351 roof hairpin; other site 246196004352 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 246196004353 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246196004354 ring oligomerisation interface [polypeptide binding]; other site 246196004355 ATP/Mg binding site [chemical binding]; other site 246196004356 stacking interactions; other site 246196004357 hinge regions; other site 246196004358 Cupin domain; Region: Cupin_2; pfam07883 246196004359 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196004360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196004361 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196004362 enoyl-CoA hydratase; Validated; Region: PRK08139 246196004363 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196004364 substrate binding site [chemical binding]; other site 246196004365 oxyanion hole (OAH) forming residues; other site 246196004366 trimer interface [polypeptide binding]; other site 246196004367 short chain dehydrogenase; Validated; Region: PRK08264 246196004368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196004369 NAD(P) binding site [chemical binding]; other site 246196004370 active site 246196004371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004373 Transcription factor WhiB; Region: Whib; pfam02467 246196004374 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 246196004375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004376 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004377 DNA binding residues [nucleotide binding] 246196004378 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 246196004379 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 246196004380 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 246196004381 active site 246196004382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 246196004383 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 246196004384 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 246196004385 active site 246196004386 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246196004387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196004388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004389 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196004390 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 246196004391 PhoU domain; Region: PhoU; pfam01895 246196004392 PhoU domain; Region: PhoU; pfam01895 246196004393 benzoylformate decarboxylase; Reviewed; Region: PRK07092 246196004394 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196004395 PYR/PP interface [polypeptide binding]; other site 246196004396 dimer interface [polypeptide binding]; other site 246196004397 TPP binding site [chemical binding]; other site 246196004398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196004399 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 246196004400 TPP-binding site [chemical binding]; other site 246196004401 dimer interface [polypeptide binding]; other site 246196004402 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 246196004403 Putative oxalocrotonate tautomerase enzyme; Region: Tautomerase_3; pfam14832 246196004404 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 246196004405 hexamer interface [polypeptide binding]; other site 246196004406 active site 2 [active] 246196004407 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 246196004408 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 246196004409 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 246196004410 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 246196004411 GMP synthase; Reviewed; Region: guaA; PRK00074 246196004412 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 246196004413 AMP/PPi binding site [chemical binding]; other site 246196004414 candidate oxyanion hole; other site 246196004415 catalytic triad [active] 246196004416 potential glutamine specificity residues [chemical binding]; other site 246196004417 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 246196004418 ATP Binding subdomain [chemical binding]; other site 246196004419 Ligand Binding sites [chemical binding]; other site 246196004420 Dimerization subdomain; other site 246196004421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196004424 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196004425 substrate binding pocket [chemical binding]; other site 246196004426 membrane-bound complex binding site; other site 246196004427 hinge residues; other site 246196004428 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196004430 dimer interface [polypeptide binding]; other site 246196004431 conserved gate region; other site 246196004432 putative PBP binding loops; other site 246196004433 ABC-ATPase subunit interface; other site 246196004434 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196004435 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196004436 Walker A/P-loop; other site 246196004437 ATP binding site [chemical binding]; other site 246196004438 Q-loop/lid; other site 246196004439 ABC transporter signature motif; other site 246196004440 Walker B; other site 246196004441 D-loop; other site 246196004442 H-loop/switch region; other site 246196004443 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196004444 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 246196004445 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 246196004446 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 246196004447 active site 246196004448 catalytic triad [active] 246196004449 calcium binding site [ion binding]; other site 246196004450 DNA Polymerase Y-family; Region: PolY_like; cd03468 246196004451 active site 246196004452 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 246196004453 DNA binding site [nucleotide binding] 246196004454 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 246196004455 active site 246196004456 short chain dehydrogenase; Provisional; Region: PRK07201 246196004457 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 246196004458 putative NAD(P) binding site [chemical binding]; other site 246196004459 active site 246196004460 putative substrate binding site [chemical binding]; other site 246196004461 classical (c) SDRs; Region: SDR_c; cd05233 246196004462 NAD(P) binding site [chemical binding]; other site 246196004463 active site 246196004464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196004465 Ligand Binding Site [chemical binding]; other site 246196004466 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196004467 Ligand Binding Site [chemical binding]; other site 246196004468 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196004469 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196004470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196004471 salt bridge; other site 246196004472 non-specific DNA binding site [nucleotide binding]; other site 246196004473 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196004474 sequence-specific DNA binding site [nucleotide binding]; other site 246196004475 short chain dehydrogenase; Provisional; Region: PRK06180 246196004476 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196004477 NADP binding site [chemical binding]; other site 246196004478 active site 246196004479 steroid binding site; other site 246196004480 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196004481 classical (c) SDRs; Region: SDR_c; cd05233 246196004482 NAD(P) binding site [chemical binding]; other site 246196004483 active site 246196004484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196004485 salt bridge; other site 246196004486 non-specific DNA binding site [nucleotide binding]; other site 246196004487 sequence-specific DNA binding site [nucleotide binding]; other site 246196004488 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 246196004489 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 246196004490 active site 246196004491 PHP Thumb interface [polypeptide binding]; other site 246196004492 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 246196004493 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 246196004494 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 246196004495 generic binding surface II; other site 246196004496 generic binding surface I; other site 246196004497 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 246196004498 FMN binding site [chemical binding]; other site 246196004499 dimer interface [polypeptide binding]; other site 246196004500 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 246196004501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196004502 HAMP domain; Region: HAMP; pfam00672 246196004503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196004504 ATP binding site [chemical binding]; other site 246196004505 Mg2+ binding site [ion binding]; other site 246196004506 G-X-G motif; other site 246196004507 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 246196004508 Protein of unknown function (DUF742); Region: DUF742; pfam05331 246196004509 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246196004510 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 246196004511 G1 box; other site 246196004512 GTP/Mg2+ binding site [chemical binding]; other site 246196004513 G2 box; other site 246196004514 Switch I region; other site 246196004515 G3 box; other site 246196004516 Switch II region; other site 246196004517 G4 box; other site 246196004518 G5 box; other site 246196004519 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246196004520 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 246196004521 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246196004522 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196004523 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196004524 phosphopeptide binding site; other site 246196004525 Protein of unknown function (DUF1373); Region: DUF1373; pfam07117 246196004526 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196004527 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196004528 phosphopeptide binding site; other site 246196004529 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196004530 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 246196004531 Walker A/P-loop; other site 246196004532 ATP binding site [chemical binding]; other site 246196004533 Q-loop/lid; other site 246196004534 ABC transporter signature motif; other site 246196004535 Walker B; other site 246196004536 D-loop; other site 246196004537 H-loop/switch region; other site 246196004538 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196004539 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246196004540 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196004541 PQQ-like domain; Region: PQQ_2; pfam13360 246196004542 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 246196004543 active site 246196004544 FMN binding site [chemical binding]; other site 246196004545 substrate binding site [chemical binding]; other site 246196004546 putative catalytic residue [active] 246196004547 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 246196004548 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 246196004549 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 246196004550 homodimer interface [polypeptide binding]; other site 246196004551 NADP binding site [chemical binding]; other site 246196004552 substrate binding site [chemical binding]; other site 246196004553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196004554 S-adenosylmethionine binding site [chemical binding]; other site 246196004555 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 246196004556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004558 hypothetical protein; Provisional; Region: PRK06834 246196004559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196004560 S-adenosylmethionine binding site [chemical binding]; other site 246196004561 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 246196004562 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 246196004563 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246196004564 homodimer interface [polypeptide binding]; other site 246196004565 substrate-cofactor binding pocket; other site 246196004566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004567 catalytic residue [active] 246196004568 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 246196004569 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196004570 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196004571 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 246196004572 putative active site [active] 246196004573 putative catalytic site [active] 246196004574 putative DNA binding site [nucleotide binding]; other site 246196004575 putative phosphate binding site [ion binding]; other site 246196004576 metal binding site A [ion binding]; metal-binding site 246196004577 putative AP binding site [nucleotide binding]; other site 246196004578 putative metal binding site B [ion binding]; other site 246196004579 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 246196004580 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 246196004581 active site 246196004582 HIGH motif; other site 246196004583 dimer interface [polypeptide binding]; other site 246196004584 KMSKS motif; other site 246196004585 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 246196004586 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 246196004587 Nitronate monooxygenase; Region: NMO; pfam03060 246196004588 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196004589 FMN binding site [chemical binding]; other site 246196004590 substrate binding site [chemical binding]; other site 246196004591 putative catalytic residue [active] 246196004592 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 246196004593 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 246196004594 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196004595 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196004596 inhibitor-cofactor binding pocket; inhibition site 246196004597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004598 catalytic residue [active] 246196004599 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196004600 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 246196004601 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 246196004602 NAD(P) binding site [chemical binding]; other site 246196004603 catalytic residues [active] 246196004604 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 246196004605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004607 DNA binding residues [nucleotide binding] 246196004608 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 246196004609 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 246196004610 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 246196004611 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 246196004612 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 246196004613 L-aspartate oxidase; Provisional; Region: PRK06175 246196004614 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196004615 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 246196004616 putative Iron-sulfur protein interface [polypeptide binding]; other site 246196004617 putative proximal heme binding site [chemical binding]; other site 246196004618 putative SdhC-like subunit interface [polypeptide binding]; other site 246196004619 putative distal heme binding site [chemical binding]; other site 246196004620 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 246196004621 putative Iron-sulfur protein interface [polypeptide binding]; other site 246196004622 putative proximal heme binding site [chemical binding]; other site 246196004623 putative SdhD-like interface [polypeptide binding]; other site 246196004624 putative distal heme binding site [chemical binding]; other site 246196004625 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 246196004626 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 246196004627 active site 246196004628 catalytic motif [active] 246196004629 Zn binding site [ion binding]; other site 246196004630 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 246196004631 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 246196004632 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 246196004633 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 246196004634 adenosine deaminase; Provisional; Region: PRK09358 246196004635 active site 246196004636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196004637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196004638 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 246196004639 putative substrate binding pocket [chemical binding]; other site 246196004640 dimerization interface [polypeptide binding]; other site 246196004641 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 246196004642 Aspartase; Region: Aspartase; cd01357 246196004643 active sites [active] 246196004644 tetramer interface [polypeptide binding]; other site 246196004645 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 246196004646 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 246196004647 metal binding site [ion binding]; metal-binding site 246196004648 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 246196004649 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246196004650 homotrimer interaction site [polypeptide binding]; other site 246196004651 putative active site [active] 246196004652 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 246196004653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004654 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196004655 Na binding site [ion binding]; other site 246196004656 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196004657 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196004658 Cupin domain; Region: Cupin_2; cl17218 246196004659 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196004660 classical (c) SDRs; Region: SDR_c; cd05233 246196004661 NAD(P) binding site [chemical binding]; other site 246196004662 active site 246196004663 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 246196004664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004666 DNA binding residues [nucleotide binding] 246196004667 AAA ATPase domain; Region: AAA_16; pfam13191 246196004668 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196004669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196004670 DNA binding residues [nucleotide binding] 246196004671 dimerization interface [polypeptide binding]; other site 246196004672 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 246196004673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004674 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196004675 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196004676 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 246196004677 L-aspartate oxidase; Provisional; Region: PRK06175 246196004678 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196004679 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196004680 active site 246196004681 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 246196004682 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 246196004683 active site 246196004684 substrate binding site [chemical binding]; other site 246196004685 metal binding site [ion binding]; metal-binding site 246196004686 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196004687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196004688 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 246196004689 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 246196004690 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 246196004691 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196004692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004695 purine nucleoside phosphorylase; Provisional; Region: PRK08202 246196004696 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 246196004697 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 246196004698 amidohydrolase; Region: amidohydrolases; TIGR01891 246196004699 metal binding site [ion binding]; metal-binding site 246196004700 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 246196004701 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 246196004702 metal binding site [ion binding]; metal-binding site 246196004703 putative dimer interface [polypeptide binding]; other site 246196004704 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 246196004705 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 246196004706 putative ligand binding site [chemical binding]; other site 246196004707 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 246196004708 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196004709 Walker A/P-loop; other site 246196004710 ATP binding site [chemical binding]; other site 246196004711 Q-loop/lid; other site 246196004712 ABC transporter signature motif; other site 246196004713 Walker B; other site 246196004714 D-loop; other site 246196004715 H-loop/switch region; other site 246196004716 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196004717 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196004718 TM-ABC transporter signature motif; other site 246196004719 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 246196004720 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 246196004721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196004722 motif II; other site 246196004723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196004724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196004725 DNA binding site [nucleotide binding] 246196004726 domain linker motif; other site 246196004727 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 246196004728 ligand binding site [chemical binding]; other site 246196004729 dimerization interface (open form) [polypeptide binding]; other site 246196004730 dimerization interface (closed form) [polypeptide binding]; other site 246196004731 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196004732 TM-ABC transporter signature motif; other site 246196004733 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196004734 TM-ABC transporter signature motif; other site 246196004735 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196004736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196004737 Walker A/P-loop; other site 246196004738 ATP binding site [chemical binding]; other site 246196004739 Q-loop/lid; other site 246196004740 ABC transporter signature motif; other site 246196004741 Walker B; other site 246196004742 D-loop; other site 246196004743 H-loop/switch region; other site 246196004744 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196004745 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196004746 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 246196004747 putative ligand binding site [chemical binding]; other site 246196004748 L-ribulokinase; Region: L-ribulokinase; TIGR01234 246196004749 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 246196004750 N- and C-terminal domain interface [polypeptide binding]; other site 246196004751 active site 246196004752 MgATP binding site [chemical binding]; other site 246196004753 catalytic site [active] 246196004754 metal binding site [ion binding]; metal-binding site 246196004755 carbohydrate binding site [chemical binding]; other site 246196004756 homodimer interface [polypeptide binding]; other site 246196004757 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 246196004758 intersubunit interface [polypeptide binding]; other site 246196004759 active site 246196004760 Zn2+ binding site [ion binding]; other site 246196004761 L-arabinose isomerase; Provisional; Region: PRK02929 246196004762 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 246196004763 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 246196004764 trimer interface [polypeptide binding]; other site 246196004765 putative substrate binding site [chemical binding]; other site 246196004766 putative metal binding site [ion binding]; other site 246196004767 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246196004768 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 246196004769 Helix-turn-helix domain; Region: HTH_38; pfam13936 246196004770 Integrase core domain; Region: rve; pfam00665 246196004771 Transposase; Region: HTH_Tnp_1; cl17663 246196004772 putative transposase OrfB; Reviewed; Region: PHA02517 246196004773 HTH-like domain; Region: HTH_21; pfam13276 246196004774 Integrase core domain; Region: rve; pfam00665 246196004775 Integrase core domain; Region: rve_3; pfam13683 246196004776 Transposase; Region: HTH_Tnp_1; cl17663 246196004777 Ribosomal protein L11, RNA binding domain; Region: Ribosomal_L11; pfam00298 246196004778 Integrase core domain; Region: rve; pfam00665 246196004779 Integrase core domain; Region: rve_3; pfam13683 246196004780 Transposase; Region: HTH_Tnp_1; cl17663 246196004781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196004782 putative transposase OrfB; Reviewed; Region: PHA02517 246196004783 HTH-like domain; Region: HTH_21; pfam13276 246196004784 Integrase core domain; Region: rve; pfam00665 246196004785 Integrase core domain; Region: rve_3; pfam13683 246196004786 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196004787 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196004788 Transposase, Mutator family; Region: Transposase_mut; cl19537 246196004789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 246196004790 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196004791 putative active site [active] 246196004792 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 246196004793 putative active site pocket [active] 246196004794 dimerization interface [polypeptide binding]; other site 246196004795 putative catalytic residue [active] 246196004796 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 246196004797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196004799 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 246196004800 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 246196004801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196004802 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246196004803 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 246196004804 active site 246196004805 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196004806 classical (c) SDRs; Region: SDR_c; cd05233 246196004807 NAD(P) binding site [chemical binding]; other site 246196004808 active site 246196004809 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196004810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196004811 substrate binding site [chemical binding]; other site 246196004812 oxyanion hole (OAH) forming residues; other site 246196004813 trimer interface [polypeptide binding]; other site 246196004814 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 246196004815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004816 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 246196004817 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196004818 FAD binding pocket [chemical binding]; other site 246196004819 FAD binding motif [chemical binding]; other site 246196004820 phosphate binding motif [ion binding]; other site 246196004821 beta-alpha-beta structure motif; other site 246196004822 NAD binding pocket [chemical binding]; other site 246196004823 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196004824 catalytic loop [active] 246196004825 iron binding site [ion binding]; other site 246196004826 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 246196004827 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196004828 putative di-iron ligands [ion binding]; other site 246196004829 Methyltransferase domain; Region: Methyltransf_12; pfam08242 246196004830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196004831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196004832 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196004833 FAD binding domain; Region: FAD_binding_4; pfam01565 246196004834 Berberine and berberine like; Region: BBE; pfam08031 246196004835 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246196004836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004837 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196004838 DNA binding residues [nucleotide binding] 246196004839 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 246196004840 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196004841 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196004842 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196004843 active site 246196004844 catalytic tetrad [active] 246196004845 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 246196004846 Cupin domain; Region: Cupin_2; cl17218 246196004847 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 246196004848 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 246196004849 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 246196004850 putative DNA binding site [nucleotide binding]; other site 246196004851 catalytic residue [active] 246196004852 putative H2TH interface [polypeptide binding]; other site 246196004853 putative catalytic residues [active] 246196004854 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246196004855 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246196004856 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196004857 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 246196004858 ATP binding site [chemical binding]; other site 246196004859 putative Mg++ binding site [ion binding]; other site 246196004860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196004861 nucleotide binding region [chemical binding]; other site 246196004862 ATP-binding site [chemical binding]; other site 246196004863 DEAD/H associated; Region: DEAD_assoc; pfam08494 246196004864 Winged helix DNA-binding domain; Region: HTH_42; cl19833 246196004865 Lipase maturation factor; Region: LMF1; pfam06762 246196004866 hypothetical protein; Provisional; Region: PRK06194 246196004867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196004868 NAD(P) binding site [chemical binding]; other site 246196004869 active site 246196004870 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 246196004871 tetrameric interface [polypeptide binding]; other site 246196004872 NAD binding site [chemical binding]; other site 246196004873 catalytic residues [active] 246196004874 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196004875 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 246196004876 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196004877 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196004878 inhibitor-cofactor binding pocket; inhibition site 246196004879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196004880 catalytic residue [active] 246196004881 Restriction endonuclease; Region: Mrr_cat; pfam04471 246196004882 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246196004883 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 246196004884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196004885 S-adenosylmethionine binding site [chemical binding]; other site 246196004886 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 246196004887 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 246196004888 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 246196004889 Cytochrome P450; Region: p450; cl12078 246196004890 ribonuclease Z; Reviewed; Region: PRK00055 246196004891 YrhK-like protein; Region: YrhK; pfam14145 246196004892 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 246196004893 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 246196004894 oxidoreductase; Provisional; Region: PRK07985 246196004895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196004896 NAD(P) binding site [chemical binding]; other site 246196004897 active site 246196004898 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 246196004899 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 246196004900 active site 246196004901 DNA binding site [nucleotide binding] 246196004902 Int/Topo IB signature motif; other site 246196004903 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246196004904 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246196004905 anti sigma factor interaction site; other site 246196004906 regulatory phosphorylation site [posttranslational modification]; other site 246196004907 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 246196004908 Phospholipid methyltransferase; Region: PEMT; cl17370 246196004909 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196004910 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196004911 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 246196004912 putative NAD(P) binding site [chemical binding]; other site 246196004913 catalytic Zn binding site [ion binding]; other site 246196004914 structural Zn binding site [ion binding]; other site 246196004915 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 246196004916 Probable pheophorbidase; Region: PLN02965; cl17657 246196004917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196004918 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196004919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196004920 putative substrate translocation pore; other site 246196004921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196004922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196004923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196004924 dimerization interface [polypeptide binding]; other site 246196004925 ChaB; Region: ChaB; pfam06150 246196004926 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 246196004927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 246196004928 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 246196004929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196004930 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246196004931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196004932 DNA binding residues [nucleotide binding] 246196004933 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196004934 active site 246196004935 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 246196004936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196004937 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 246196004938 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196004939 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196004940 carboxyltransferase (CT) interaction site; other site 246196004941 biotinylation site [posttranslational modification]; other site 246196004942 Fe-S metabolizm associated domain; Region: SufE; cl00951 246196004943 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 246196004944 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 246196004945 active site residue [active] 246196004946 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 246196004947 active site residue [active] 246196004948 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 246196004949 active site 246196004950 dimer interface [polypeptide binding]; other site 246196004951 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 246196004952 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196004953 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196004954 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196004955 Bacterial PH domain; Region: bPH_2; pfam03703 246196004956 Predicted membrane protein [Function unknown]; Region: COG2246 246196004957 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 246196004958 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196004959 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 246196004960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196004961 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 246196004962 FAD binding site [chemical binding]; other site 246196004963 homotetramer interface [polypeptide binding]; other site 246196004964 substrate binding pocket [chemical binding]; other site 246196004965 catalytic base [active] 246196004966 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 246196004967 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 246196004968 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 246196004969 TIGR03089 family protein; Region: TIGR03089 246196004970 Transcriptional regulator [Transcription]; Region: LytR; COG1316 246196004971 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196004972 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 246196004973 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 246196004974 NADP binding site [chemical binding]; other site 246196004975 active site 246196004976 putative substrate binding site [chemical binding]; other site 246196004977 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246196004978 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 246196004979 Probable Catalytic site; other site 246196004980 metal-binding site 246196004981 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 246196004982 nudix motif; other site 246196004983 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 246196004984 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 246196004985 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 246196004986 putative FMN binding site [chemical binding]; other site 246196004987 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 246196004988 phosphate binding site [ion binding]; other site 246196004989 dimer interface [polypeptide binding]; other site 246196004990 substrate binding site [chemical binding]; other site 246196004991 Transcription factor WhiB; Region: Whib; pfam02467 246196004992 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 246196004993 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 246196004994 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 246196004995 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 246196004996 active site 246196004997 substrate binding site [chemical binding]; other site 246196004998 metal binding site [ion binding]; metal-binding site 246196004999 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 246196005000 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 246196005001 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196005002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196005003 amino acid transporter; Region: 2A0306; TIGR00909 246196005004 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196005005 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 246196005006 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 246196005007 Di-iron ligands [ion binding]; other site 246196005008 Rubredoxin [Energy production and conversion]; Region: COG1773 246196005009 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 246196005010 iron binding site [ion binding]; other site 246196005011 Rubredoxin [Energy production and conversion]; Region: COG1773 246196005012 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 246196005013 iron binding site [ion binding]; other site 246196005014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005016 Predicted membrane protein [Function unknown]; Region: COG2323 246196005017 Predicted membrane protein [Function unknown]; Region: COG2860 246196005018 UPF0126 domain; Region: UPF0126; pfam03458 246196005019 UPF0126 domain; Region: UPF0126; pfam03458 246196005020 Polysulphide reductase, NrfD; Region: NrfD; cl19193 246196005021 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 246196005022 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 246196005023 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 246196005024 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 246196005025 G1 box; other site 246196005026 putative GEF interaction site [polypeptide binding]; other site 246196005027 GTP/Mg2+ binding site [chemical binding]; other site 246196005028 Switch I region; other site 246196005029 G2 box; other site 246196005030 G3 box; other site 246196005031 Switch II region; other site 246196005032 G4 box; other site 246196005033 G5 box; other site 246196005034 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 246196005035 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 246196005036 selenocysteine synthase; Provisional; Region: PRK04311 246196005037 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 246196005038 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196005039 selenophosphate synthetase; Provisional; Region: PRK00943 246196005040 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 246196005041 dimerization interface [polypeptide binding]; other site 246196005042 putative ATP binding site [chemical binding]; other site 246196005043 Tetratricopeptide repeat; Region: TPR_20; pfam14561 246196005044 Tetratricopeptide repeat; Region: TPR_19; pfam14559 246196005045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005046 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196005047 Walker A motif; other site 246196005048 ATP binding site [chemical binding]; other site 246196005049 Walker B motif; other site 246196005050 arginine finger; other site 246196005051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196005052 TPR motif; other site 246196005053 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246196005054 binding surface 246196005055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196005056 binding surface 246196005057 TPR repeat; Region: TPR_11; pfam13414 246196005058 TPR motif; other site 246196005059 TPR repeat; Region: TPR_11; pfam13414 246196005060 Cation efflux family; Region: Cation_efflux; cl00316 246196005061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246196005062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196005063 salt bridge; other site 246196005064 non-specific DNA binding site [nucleotide binding]; other site 246196005065 sequence-specific DNA binding site [nucleotide binding]; other site 246196005066 Integrase core domain; Region: rve; pfam00665 246196005067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 246196005068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005069 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196005070 Walker A motif; other site 246196005071 ATP binding site [chemical binding]; other site 246196005072 Walker B motif; other site 246196005073 Integrase core domain; Region: rve; pfam00665 246196005074 Integrase core domain; Region: rve_3; pfam13683 246196005075 Transposase; Region: HTH_Tnp_1; cl17663 246196005076 Ribosomal protein L11, RNA binding domain; Region: Ribosomal_L11; pfam00298 246196005077 Integrase core domain; Region: rve_3; pfam13683 246196005078 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196005079 putative transposase OrfB; Reviewed; Region: PHA02517 246196005080 HTH-like domain; Region: HTH_21; pfam13276 246196005081 Integrase core domain; Region: rve; pfam00665 246196005082 Integrase core domain; Region: rve_3; pfam13683 246196005083 Transposase; Region: HTH_Tnp_1; cl17663 246196005084 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246196005085 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 246196005086 dimer interface [polypeptide binding]; other site 246196005087 RAM signalling pathway protein; Region: SOG2; pfam10428 246196005088 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 246196005089 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 246196005090 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 246196005091 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 246196005092 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 246196005093 TMP-binding site; other site 246196005094 ATP-binding site [chemical binding]; other site 246196005095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196005096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196005097 active site 246196005098 phosphorylation site [posttranslational modification] 246196005099 intermolecular recognition site; other site 246196005100 dimerization interface [polypeptide binding]; other site 246196005101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196005102 DNA binding site [nucleotide binding] 246196005103 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 246196005104 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196005105 dimerization interface [polypeptide binding]; other site 246196005106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196005107 dimer interface [polypeptide binding]; other site 246196005108 phosphorylation site [posttranslational modification] 246196005109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196005110 ATP binding site [chemical binding]; other site 246196005111 Mg2+ binding site [ion binding]; other site 246196005112 G-X-G motif; other site 246196005113 lipoprotein LpqB; Provisional; Region: PRK13616 246196005114 Sporulation and spore germination; Region: Germane; pfam10646 246196005115 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 246196005116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196005117 active site 246196005118 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 246196005119 30S subunit binding site; other site 246196005120 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 246196005121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196005122 ATP binding site [chemical binding]; other site 246196005123 putative Mg++ binding site [ion binding]; other site 246196005124 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 246196005125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196005126 nucleotide binding region [chemical binding]; other site 246196005127 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 246196005128 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196005129 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196005130 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246196005131 BCCT family transporter; Region: BCCT; pfam02028 246196005132 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 246196005133 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196005134 FAD binding pocket [chemical binding]; other site 246196005135 FAD binding motif [chemical binding]; other site 246196005136 phosphate binding motif [ion binding]; other site 246196005137 beta-alpha-beta structure motif; other site 246196005138 NAD binding pocket [chemical binding]; other site 246196005139 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005140 catalytic loop [active] 246196005141 iron binding site [ion binding]; other site 246196005142 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 246196005143 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196005144 putative di-iron ligands [ion binding]; other site 246196005145 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196005146 Predicted GTPases [General function prediction only]; Region: COG1162 246196005147 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 246196005148 GTPase/Zn-binding domain interface [polypeptide binding]; other site 246196005149 GTP/Mg2+ binding site [chemical binding]; other site 246196005150 G4 box; other site 246196005151 G5 box; other site 246196005152 G1 box; other site 246196005153 Switch I region; other site 246196005154 G2 box; other site 246196005155 G3 box; other site 246196005156 Switch II region; other site 246196005157 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 246196005158 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 246196005159 hinge; other site 246196005160 active site 246196005161 Uncharacterized conserved protein [Function unknown]; Region: COG2135 246196005162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196005163 S-adenosylmethionine binding site [chemical binding]; other site 246196005164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196005165 S-adenosylmethionine binding site [chemical binding]; other site 246196005166 short chain dehydrogenase; Provisional; Region: PRK08278 246196005167 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 246196005168 NAD(P) binding site [chemical binding]; other site 246196005169 homodimer interface [polypeptide binding]; other site 246196005170 active site 246196005171 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 246196005172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196005173 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196005174 dimerization interface [polypeptide binding]; other site 246196005175 substrate binding pocket [chemical binding]; other site 246196005176 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 246196005177 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196005178 dimer interface [polypeptide binding]; other site 246196005179 active site 246196005180 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 246196005181 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196005182 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246196005183 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 246196005184 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 246196005185 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 246196005186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005187 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196005188 Walker A motif; other site 246196005189 ATP binding site [chemical binding]; other site 246196005190 Walker B motif; other site 246196005191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196005192 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196005193 DNA binding residues [nucleotide binding] 246196005194 dimerization interface [polypeptide binding]; other site 246196005195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196005196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196005197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196005198 dimerization interface [polypeptide binding]; other site 246196005199 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005200 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005203 active site 246196005204 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005205 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196005206 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196005207 active site 246196005208 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 246196005209 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005210 catalytic loop [active] 246196005211 iron binding site [ion binding]; other site 246196005212 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 246196005213 FAD binding pocket [chemical binding]; other site 246196005214 FAD binding motif [chemical binding]; other site 246196005215 phosphate binding motif [ion binding]; other site 246196005216 beta-alpha-beta structure motif; other site 246196005217 NAD binding pocket [chemical binding]; other site 246196005218 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196005219 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196005220 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 246196005221 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 246196005222 putative NAD(P) binding site [chemical binding]; other site 246196005223 active site 246196005224 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 246196005225 inter-subunit interface; other site 246196005226 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 246196005227 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196005228 iron-sulfur cluster [ion binding]; other site 246196005229 [2Fe-2S] cluster binding site [ion binding]; other site 246196005230 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 246196005231 putative alpha subunit interface [polypeptide binding]; other site 246196005232 putative active site [active] 246196005233 putative substrate binding site [chemical binding]; other site 246196005234 Fe binding site [ion binding]; other site 246196005235 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 246196005236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196005237 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196005238 dimerization interface [polypeptide binding]; other site 246196005239 substrate binding pocket [chemical binding]; other site 246196005240 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 246196005241 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 246196005242 active site 246196005243 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 246196005244 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 246196005245 active site 246196005246 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 246196005247 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 246196005248 putative deacylase active site [active] 246196005249 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 246196005250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196005251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196005252 DNA binding residues [nucleotide binding] 246196005253 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 246196005254 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196005255 carboxyltransferase (CT) interaction site; other site 246196005256 biotinylation site [posttranslational modification]; other site 246196005257 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 246196005258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 246196005259 Histidine kinase; Region: HisKA_2; pfam07568 246196005260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196005261 ATP binding site [chemical binding]; other site 246196005262 Mg2+ binding site [ion binding]; other site 246196005263 G-X-G motif; other site 246196005264 Transcription factor WhiB; Region: Whib; pfam02467 246196005265 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 246196005266 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246196005267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 246196005268 SEC-C motif; Region: SEC-C; cl19389 246196005269 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 246196005270 trimer interface [polypeptide binding]; other site 246196005271 active site 246196005272 dimer interface [polypeptide binding]; other site 246196005273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196005274 Coenzyme A binding pocket [chemical binding]; other site 246196005275 isochorismate synthase DhbC; Validated; Region: PRK06923 246196005276 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246196005277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196005278 catalytic core [active] 246196005279 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246196005280 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196005281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196005282 P-loop; other site 246196005283 Magnesium ion binding site [ion binding]; other site 246196005284 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246196005285 active site 246196005286 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246196005287 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246196005288 ATP binding site [chemical binding]; other site 246196005289 Mg++ binding site [ion binding]; other site 246196005290 motif III; other site 246196005291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196005292 nucleotide binding region [chemical binding]; other site 246196005293 ATP-binding site [chemical binding]; other site 246196005294 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246196005295 dinuclear metal binding motif [ion binding]; other site 246196005296 Zonular occludens toxin (Zot); Region: Zot; cl17485 246196005297 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 246196005298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005300 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 246196005301 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 246196005302 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 246196005303 ATP binding site [chemical binding]; other site 246196005304 substrate interface [chemical binding]; other site 246196005305 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196005306 active site residue [active] 246196005307 TIGR02569 family protein; Region: TIGR02569_actnb 246196005308 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246196005309 active site 246196005310 DNA binding site [nucleotide binding] 246196005311 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196005312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196005313 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196005314 catalytic site [active] 246196005315 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 246196005316 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 246196005317 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 246196005318 Part of AAA domain; Region: AAA_19; pfam13245 246196005319 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 246196005320 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 246196005321 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 246196005322 Predicted membrane protein [Function unknown]; Region: COG4270 246196005323 Ion channel; Region: Ion_trans_2; pfam07885 246196005324 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 246196005325 TrkA-N domain; Region: TrkA_N; pfam02254 246196005326 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 246196005327 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 246196005328 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 246196005329 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 246196005330 putative NADH binding site [chemical binding]; other site 246196005331 putative active site [active] 246196005332 nudix motif; other site 246196005333 putative metal binding site [ion binding]; other site 246196005334 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 246196005335 catalytic residues [active] 246196005336 MAEBL; Provisional; Region: PTZ00121 246196005337 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 246196005338 Part of AAA domain; Region: AAA_19; pfam13245 246196005339 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 246196005340 HRDC domain; Region: HRDC; pfam00570 246196005341 Transcription factor WhiB; Region: Whib; pfam02467 246196005342 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 246196005343 active site 246196005344 ATP binding site [chemical binding]; other site 246196005345 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 246196005346 Uncharacterized conserved protein [Function unknown]; Region: COG5282 246196005347 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 246196005348 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246196005349 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246196005350 hypothetical protein; Validated; Region: PRK00068 246196005351 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196005352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196005353 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 246196005354 DNA binding site [nucleotide binding] 246196005355 Bacterial transcriptional activator domain; Region: BTAD; smart01043 246196005356 Predicted ATPase [General function prediction only]; Region: COG3899 246196005357 AAA ATPase domain; Region: AAA_16; pfam13191 246196005358 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196005359 FAD binding domain; Region: FAD_binding_4; pfam01565 246196005360 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196005361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005363 short chain dehydrogenase; Validated; Region: PRK08264 246196005364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196005365 NAD(P) binding site [chemical binding]; other site 246196005366 active site 246196005367 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196005368 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246196005369 DNA binding residues [nucleotide binding] 246196005370 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 246196005371 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246196005372 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 246196005373 dinuclear metal binding motif [ion binding]; other site 246196005374 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 246196005375 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005376 catalytic loop [active] 246196005377 iron binding site [ion binding]; other site 246196005378 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 246196005379 FAD binding pocket [chemical binding]; other site 246196005380 conserved FAD binding motif [chemical binding]; other site 246196005381 phosphate binding motif [ion binding]; other site 246196005382 beta-alpha-beta structure motif; other site 246196005383 NAD binding pocket [chemical binding]; other site 246196005384 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 246196005385 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 246196005386 active site 246196005387 Domain of unknown function DUF59; Region: DUF59; pfam01883 246196005388 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196005389 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 246196005390 NAD binding site [chemical binding]; other site 246196005391 substrate binding site [chemical binding]; other site 246196005392 catalytic Zn binding site [ion binding]; other site 246196005393 structural Zn binding site [ion binding]; other site 246196005394 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 246196005395 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246196005396 ring oligomerisation interface [polypeptide binding]; other site 246196005397 ATP/Mg binding site [chemical binding]; other site 246196005398 stacking interactions; other site 246196005399 hinge regions; other site 246196005400 Uncharacterized conserved protein [Function unknown]; Region: COG1359 246196005401 hypothetical protein; Provisional; Region: PRK07588 246196005402 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196005403 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196005404 acyl-CoA synthetase; Validated; Region: PRK08162 246196005405 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 246196005406 acyl-activating enzyme (AAE) consensus motif; other site 246196005407 putative active site [active] 246196005408 AMP binding site [chemical binding]; other site 246196005409 putative CoA binding site [chemical binding]; other site 246196005410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005411 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196005412 putative substrate translocation pore; other site 246196005413 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196005414 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196005415 transcriptional activator TtdR; Provisional; Region: PRK09801 246196005416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196005417 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 246196005418 putative effector binding pocket; other site 246196005419 putative dimerization interface [polypeptide binding]; other site 246196005420 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 246196005421 Cupin domain; Region: Cupin_2; cl17218 246196005422 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196005423 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196005424 FMN-binding pocket [chemical binding]; other site 246196005425 flavin binding motif; other site 246196005426 phosphate binding motif [ion binding]; other site 246196005427 beta-alpha-beta structure motif; other site 246196005428 NAD binding pocket [chemical binding]; other site 246196005429 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005430 catalytic loop [active] 246196005431 iron binding site [ion binding]; other site 246196005432 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 246196005433 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005435 active site 246196005436 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005437 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196005438 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196005439 active site 2 [active] 246196005440 active site 1 [active] 246196005441 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 246196005442 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196005443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196005444 DNA-binding site [nucleotide binding]; DNA binding site 246196005445 FCD domain; Region: FCD; pfam07729 246196005446 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196005447 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196005448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196005449 active site 246196005450 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196005451 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196005452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005453 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196005454 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196005455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196005456 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196005457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005458 putative substrate translocation pore; other site 246196005459 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196005460 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196005461 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 246196005462 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196005463 active site 246196005464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196005465 active site 246196005466 metal binding site [ion binding]; metal-binding site 246196005467 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196005468 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196005469 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196005470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196005471 DNA-binding site [nucleotide binding]; DNA binding site 246196005472 FCD domain; Region: FCD; pfam07729 246196005473 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 246196005474 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196005475 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196005476 DNA binding site [nucleotide binding] 246196005477 domain linker motif; other site 246196005478 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196005479 ligand binding site [chemical binding]; other site 246196005480 dimerization interface [polypeptide binding]; other site 246196005481 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 246196005482 histidinol dehydrogenase; Region: hisD; TIGR00069 246196005483 NAD binding site [chemical binding]; other site 246196005484 dimerization interface [polypeptide binding]; other site 246196005485 product binding site; other site 246196005486 substrate binding site [chemical binding]; other site 246196005487 zinc binding site [ion binding]; other site 246196005488 catalytic residues [active] 246196005489 short chain dehydrogenase; Region: adh_short; pfam00106 246196005490 classical (c) SDRs; Region: SDR_c; cd05233 246196005491 NAD(P) binding site [chemical binding]; other site 246196005492 active site 246196005493 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 246196005494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196005495 Walker A/P-loop; other site 246196005496 ATP binding site [chemical binding]; other site 246196005497 Q-loop/lid; other site 246196005498 ABC transporter signature motif; other site 246196005499 Walker B; other site 246196005500 D-loop; other site 246196005501 H-loop/switch region; other site 246196005502 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246196005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196005504 dimer interface [polypeptide binding]; other site 246196005505 conserved gate region; other site 246196005506 putative PBP binding loops; other site 246196005507 ABC-ATPase subunit interface; other site 246196005508 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 246196005509 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 246196005510 DNA binding residues [nucleotide binding] 246196005511 TOBE domain; Region: TOBE; cl01440 246196005512 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196005513 classical (c) SDRs; Region: SDR_c; cd05233 246196005514 NAD(P) binding site [chemical binding]; other site 246196005515 active site 246196005516 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196005517 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246196005518 GntP family permease; Region: GntP_permease; pfam02447 246196005519 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005520 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 246196005521 active site 246196005522 catalytic residues [active] 246196005523 metal binding site [ion binding]; metal-binding site 246196005524 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196005525 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196005526 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196005527 short chain dehydrogenase; Provisional; Region: PRK06180 246196005528 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196005529 NADP binding site [chemical binding]; other site 246196005530 active site 246196005531 steroid binding site; other site 246196005532 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196005533 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196005534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005535 putative substrate translocation pore; other site 246196005536 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196005537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196005538 NAD(P) binding site [chemical binding]; other site 246196005539 active site 246196005540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005542 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 246196005543 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196005544 catalytic residue [active] 246196005545 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 246196005546 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196005547 NAD(P) binding site [chemical binding]; other site 246196005548 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 246196005549 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 246196005550 catalytic Zn binding site [ion binding]; other site 246196005551 NAD binding site [chemical binding]; other site 246196005552 structural Zn binding site [ion binding]; other site 246196005553 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196005554 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196005555 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 246196005556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196005557 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196005558 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196005559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196005560 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196005561 Phosphotransferase enzyme family; Region: APH; pfam01636 246196005562 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196005563 putative active site [active] 246196005564 putative substrate binding site [chemical binding]; other site 246196005565 ATP binding site [chemical binding]; other site 246196005566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005569 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196005570 putative substrate translocation pore; other site 246196005571 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196005572 active site 246196005573 non-prolyl cis peptide bond; other site 246196005574 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 246196005575 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196005576 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 246196005577 putative NAD(P) binding site [chemical binding]; other site 246196005578 catalytic Zn binding site [ion binding]; other site 246196005579 structural Zn binding site [ion binding]; other site 246196005580 enoyl-CoA hydratase; Provisional; Region: PRK06190 246196005581 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196005582 substrate binding site [chemical binding]; other site 246196005583 oxyanion hole (OAH) forming residues; other site 246196005584 trimer interface [polypeptide binding]; other site 246196005585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005587 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 246196005588 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196005589 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 246196005590 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196005591 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 246196005592 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 246196005593 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246196005594 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 246196005595 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 246196005596 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 246196005597 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 246196005598 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 246196005599 NADH dehydrogenase subunit G; Validated; Region: PRK07860 246196005600 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196005601 catalytic loop [active] 246196005602 iron binding site [ion binding]; other site 246196005603 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 246196005604 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196005605 molybdopterin cofactor binding site; other site 246196005606 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 246196005607 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 246196005608 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 246196005609 SLBB domain; Region: SLBB; pfam10531 246196005610 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 246196005611 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 246196005612 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 246196005613 putative dimer interface [polypeptide binding]; other site 246196005614 [2Fe-2S] cluster binding site [ion binding]; other site 246196005615 NADH dehydrogenase subunit D; Validated; Region: PRK06075 246196005616 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 246196005617 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 246196005618 NADH dehydrogenase subunit B; Validated; Region: PRK06411 246196005619 NADH dehydrogenase subunit A; Validated; Region: PRK07928 246196005620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196005621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196005622 active site 246196005623 phosphorylation site [posttranslational modification] 246196005624 intermolecular recognition site; other site 246196005625 dimerization interface [polypeptide binding]; other site 246196005626 YceI-like domain; Region: YceI; pfam04264 246196005627 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196005628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196005629 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196005630 S-adenosylmethionine binding site [chemical binding]; other site 246196005631 Phosphotransferase enzyme family; Region: APH; pfam01636 246196005632 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196005633 putative active site [active] 246196005634 putative substrate binding site [chemical binding]; other site 246196005635 ATP binding site [chemical binding]; other site 246196005636 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005637 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196005638 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196005639 active site 246196005640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005642 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 246196005643 active site 246196005644 catalytic residues [active] 246196005645 metal binding site [ion binding]; metal-binding site 246196005646 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005647 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196005648 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 246196005649 GrpB protein; Region: GrpB; pfam04229 246196005650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005652 active site 246196005653 Predicted esterase [General function prediction only]; Region: COG0627 246196005654 S-formylglutathione hydrolase; Region: PLN02442 246196005655 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196005656 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 246196005657 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 246196005658 NADP binding site [chemical binding]; other site 246196005659 dimer interface [polypeptide binding]; other site 246196005660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005662 active site 246196005663 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005664 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005665 active site 246196005666 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 246196005667 active site 246196005668 peptide chain release factor 2; Validated; Region: prfB; PRK00578 246196005669 Alpha C protein N terminal; Region: AlphaC_N; pfam08829 246196005670 This domain is found in peptide chain release factors; Region: PCRF; smart00937 246196005671 RF-1 domain; Region: RF-1; pfam00472 246196005672 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246196005673 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246196005674 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 246196005675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196005676 Walker A/P-loop; other site 246196005677 ATP binding site [chemical binding]; other site 246196005678 Q-loop/lid; other site 246196005679 ABC transporter signature motif; other site 246196005680 Walker B; other site 246196005681 D-loop; other site 246196005682 H-loop/switch region; other site 246196005683 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 246196005684 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 246196005685 FtsX-like permease family; Region: FtsX; pfam02687 246196005686 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 246196005687 SmpB-tmRNA interface; other site 246196005688 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 246196005689 homodimer interface [polypeptide binding]; other site 246196005690 homotetramer interface [polypeptide binding]; other site 246196005691 active site pocket [active] 246196005692 cleavage site 246196005693 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 246196005694 Cutinase; Region: Cutinase; pfam01083 246196005695 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196005696 beta subunit of N-acylethanolamine-hydrolyzing acid amidase; Region: NAAA-beta; pfam15508 246196005697 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 246196005698 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196005699 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196005700 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196005701 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196005702 substrate binding pocket [chemical binding]; other site 246196005703 membrane-bound complex binding site; other site 246196005704 hinge residues; other site 246196005705 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 246196005706 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 246196005707 putative metal binding site [ion binding]; other site 246196005708 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196005709 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196005710 Walker A/P-loop; other site 246196005711 ATP binding site [chemical binding]; other site 246196005712 Q-loop/lid; other site 246196005713 ABC transporter signature motif; other site 246196005714 Walker B; other site 246196005715 D-loop; other site 246196005716 H-loop/switch region; other site 246196005717 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196005718 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196005719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005720 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 246196005721 DNA-binding site [nucleotide binding]; DNA binding site 246196005722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196005723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196005724 homodimer interface [polypeptide binding]; other site 246196005725 catalytic residue [active] 246196005726 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 246196005727 nucleotide binding site [chemical binding]; other site 246196005728 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196005729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005731 Predicted metal-dependent hydrolase; Region: Metal_hydrol; cl19844 246196005732 glycoprotein BALF4; Provisional; Region: PHA03231 246196005733 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 246196005734 chorismate mutase; Provisional; Region: PRK09269 246196005735 Chorismate mutase type II; Region: CM_2; cl00693 246196005736 Cupin domain; Region: Cupin_2; cl17218 246196005737 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 246196005738 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 246196005739 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 246196005740 active site turn [active] 246196005741 phosphorylation site [posttranslational modification] 246196005742 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 246196005743 HPr interaction site; other site 246196005744 glycerol kinase (GK) interaction site [polypeptide binding]; other site 246196005745 active site 246196005746 phosphorylation site [posttranslational modification] 246196005747 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 246196005748 active site 246196005749 trimer interface [polypeptide binding]; other site 246196005750 allosteric site; other site 246196005751 active site lid [active] 246196005752 hexamer (dimer of trimers) interface [polypeptide binding]; other site 246196005753 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 246196005754 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196005755 active site 246196005756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005757 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196005758 Walker A motif; other site 246196005759 ATP binding site [chemical binding]; other site 246196005760 Walker B motif; other site 246196005761 arginine finger; other site 246196005762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196005763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196005764 DNA binding residues [nucleotide binding] 246196005765 dimerization interface [polypeptide binding]; other site 246196005766 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 246196005767 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 246196005768 active site 246196005769 active pocket/dimerization site; other site 246196005770 phosphorylation site [posttranslational modification] 246196005771 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 246196005772 dimerization domain swap beta strand [polypeptide binding]; other site 246196005773 regulatory protein interface [polypeptide binding]; other site 246196005774 active site 246196005775 regulatory phosphorylation site [posttranslational modification]; other site 246196005776 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 246196005777 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 246196005778 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 246196005779 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246196005780 DAK2 domain; Region: Dak2; cl03685 246196005781 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 246196005782 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 246196005783 amphipathic channel; other site 246196005784 Asn-Pro-Ala signature motifs; other site 246196005785 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196005786 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196005787 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196005788 Protein of unknown function, DUF488; Region: DUF488; cl01246 246196005789 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 246196005790 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 246196005791 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005792 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005793 active site 246196005794 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 246196005795 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196005796 acyl-activating enzyme (AAE) consensus motif; other site 246196005797 AMP binding site [chemical binding]; other site 246196005798 active site 246196005799 CoA binding site [chemical binding]; other site 246196005800 acyl carrier protein; Validated; Region: PRK05883 246196005801 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 246196005802 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 246196005803 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 246196005804 camphor resistance protein CrcB; Provisional; Region: PRK14228 246196005805 camphor resistance protein CrcB; Provisional; Region: PRK14216 246196005806 phosphoglucomutase; Validated; Region: PRK07564 246196005807 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 246196005808 active site 246196005809 substrate binding site [chemical binding]; other site 246196005810 metal binding site [ion binding]; metal-binding site 246196005811 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196005812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196005813 putative substrate translocation pore; other site 246196005814 Fic family protein [Function unknown]; Region: COG3177 246196005815 Fic/DOC family; Region: Fic; pfam02661 246196005816 HTH DNA binding domain; Region: HTH_13; pfam11972 246196005817 Restriction endonuclease fold toxin 5; Region: Tox-REase-5; pfam15648 246196005818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196005819 sequence-specific DNA binding site [nucleotide binding]; other site 246196005820 salt bridge; other site 246196005821 Invariant surface glycoprotein; Region: ISG65-75; cl19916 246196005822 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 246196005823 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196005824 active site 246196005825 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 246196005826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 246196005827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196005828 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196005829 Walker A motif; other site 246196005830 ATP binding site [chemical binding]; other site 246196005831 Walker B motif; other site 246196005832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246196005833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196005834 salt bridge; other site 246196005835 non-specific DNA binding site [nucleotide binding]; other site 246196005836 sequence-specific DNA binding site [nucleotide binding]; other site 246196005837 Integrase core domain; Region: rve; pfam00665 246196005838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005840 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196005841 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 246196005842 active site 246196005843 dimer interface [polypeptide binding]; other site 246196005844 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196005845 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 246196005846 NADP binding site [chemical binding]; other site 246196005847 dimer interface [polypeptide binding]; other site 246196005848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196005849 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196005850 NAD(P) binding site [chemical binding]; other site 246196005851 active site 246196005852 TIGR04222 domain; Region: near_uncomplex 246196005853 hypothetical protein; Provisional; Region: PRK05409 246196005854 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196005855 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 246196005856 NAD(P) binding site [chemical binding]; other site 246196005857 catalytic residues [active] 246196005858 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196005859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005860 DNA-binding site [nucleotide binding]; DNA binding site 246196005861 FCD domain; Region: FCD; pfam07729 246196005862 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196005863 TPP-binding site [chemical binding]; other site 246196005864 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 246196005865 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246196005866 PYR/PP interface [polypeptide binding]; other site 246196005867 dimer interface [polypeptide binding]; other site 246196005868 TPP binding site [chemical binding]; other site 246196005869 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196005870 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196005871 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196005872 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246196005873 active site 246196005874 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196005875 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196005876 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196005877 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 246196005878 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 246196005879 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196005880 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196005881 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 246196005882 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246196005883 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196005884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005885 DNA-binding site [nucleotide binding]; DNA binding site 246196005886 FCD domain; Region: FCD; pfam07729 246196005887 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 246196005888 Part of AAA domain; Region: AAA_19; pfam13245 246196005889 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 246196005890 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; cl19212 246196005891 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196005892 active site 246196005893 non-prolyl cis peptide bond; other site 246196005894 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196005895 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196005896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005900 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 246196005901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005903 Fic/DOC family; Region: Fic; cl00960 246196005904 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246196005905 metal binding triad; other site 246196005906 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 246196005907 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196005908 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196005909 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 246196005910 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 246196005911 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 246196005912 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 246196005913 allophanate hydrolase; Provisional; Region: PRK08186 246196005914 EamA-like transporter family; Region: EamA; pfam00892 246196005915 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 246196005916 EamA-like transporter family; Region: EamA; pfam00892 246196005917 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 246196005918 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196005919 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196005920 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 246196005921 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005922 active site 246196005923 PAS domain; Region: PAS_9; pfam13426 246196005924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196005925 putative active site [active] 246196005926 heme pocket [chemical binding]; other site 246196005927 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196005928 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 246196005929 DNA binding residues [nucleotide binding] 246196005930 dimer interface [polypeptide binding]; other site 246196005931 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 246196005932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196005935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196005936 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246196005937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246196005938 metal binding site [ion binding]; metal-binding site 246196005939 active site 246196005940 I-site; other site 246196005941 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 246196005942 hypothetical protein; Provisional; Region: PRK07877 246196005943 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 246196005944 ATP binding site [chemical binding]; other site 246196005945 substrate interface [chemical binding]; other site 246196005946 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 246196005947 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 246196005948 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 246196005949 putative active site [active] 246196005950 putative substrate binding site [chemical binding]; other site 246196005951 putative cosubstrate binding site; other site 246196005952 catalytic site [active] 246196005953 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 246196005954 putative active site [active] 246196005955 putative catalytic site [active] 246196005956 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 246196005957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196005958 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196005959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196005960 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196005961 classical (c) SDRs; Region: SDR_c; cd05233 246196005962 NAD(P) binding site [chemical binding]; other site 246196005963 active site 246196005964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005966 active site 246196005967 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196005968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196005969 NAD(P) binding site [chemical binding]; other site 246196005970 active site 246196005971 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 246196005972 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196005973 dimer interface [polypeptide binding]; other site 246196005974 active site 246196005975 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196005976 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196005977 active site 246196005978 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196005979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196005980 DNA-binding site [nucleotide binding]; DNA binding site 246196005981 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196005982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196005983 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196005984 sequence-specific DNA binding site [nucleotide binding]; other site 246196005985 salt bridge; other site 246196005986 short chain dehydrogenase; Provisional; Region: PRK05854 246196005987 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 246196005988 NAD(P) binding site [chemical binding]; other site 246196005989 active site 246196005990 O-methyltransferase; Region: Methyltransf_2; pfam00891 246196005991 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196005992 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196005993 acyl-activating enzyme (AAE) consensus motif; other site 246196005994 AMP binding site [chemical binding]; other site 246196005995 active site 246196005996 CoA binding site [chemical binding]; other site 246196005997 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196005998 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196005999 acyl-activating enzyme (AAE) consensus motif; other site 246196006000 AMP binding site [chemical binding]; other site 246196006001 active site 246196006002 CoA binding site [chemical binding]; other site 246196006003 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196006004 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006005 acyl-activating enzyme (AAE) consensus motif; other site 246196006006 AMP binding site [chemical binding]; other site 246196006007 active site 246196006008 CoA binding site [chemical binding]; other site 246196006009 enoyl-CoA hydratase; Provisional; Region: PRK08290 246196006010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006011 substrate binding site [chemical binding]; other site 246196006012 oxyanion hole (OAH) forming residues; other site 246196006013 trimer interface [polypeptide binding]; other site 246196006014 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196006015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006016 substrate binding site [chemical binding]; other site 246196006017 oxyanion hole (OAH) forming residues; other site 246196006018 trimer interface [polypeptide binding]; other site 246196006019 enoyl-CoA hydratase; Provisional; Region: PRK06688 246196006020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006021 substrate binding site [chemical binding]; other site 246196006022 oxyanion hole (OAH) forming residues; other site 246196006023 trimer interface [polypeptide binding]; other site 246196006024 enoyl-CoA hydratase; Provisional; Region: PRK08272 246196006025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006026 substrate binding site [chemical binding]; other site 246196006027 oxyanion hole (OAH) forming residues; other site 246196006028 trimer interface [polypeptide binding]; other site 246196006029 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196006030 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 246196006031 dimer interface [polypeptide binding]; other site 246196006032 active site 246196006033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006034 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196006035 enoyl-CoA hydratase; Provisional; Region: PRK08252 246196006036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006037 substrate binding site [chemical binding]; other site 246196006038 oxyanion hole (OAH) forming residues; other site 246196006039 trimer interface [polypeptide binding]; other site 246196006040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006041 NAD(P) binding site [chemical binding]; other site 246196006042 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196006043 active site 246196006044 enoyl-CoA hydratase; Provisional; Region: PRK06210 246196006045 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006046 substrate binding site [chemical binding]; other site 246196006047 oxyanion hole (OAH) forming residues; other site 246196006048 trimer interface [polypeptide binding]; other site 246196006049 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196006050 acyl-CoA synthetase; Validated; Region: PRK07798 246196006051 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006052 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006053 acyl-activating enzyme (AAE) consensus motif; other site 246196006054 acyl-activating enzyme (AAE) consensus motif; other site 246196006055 AMP binding site [chemical binding]; other site 246196006056 active site 246196006057 CoA binding site [chemical binding]; other site 246196006058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196006059 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196006060 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196006061 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196006062 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196006063 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196006064 active site 246196006065 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196006066 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 246196006067 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196006068 active site 246196006069 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246196006070 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196006071 molybdopterin cofactor binding site; other site 246196006072 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 246196006073 molybdopterin cofactor binding site; other site 246196006074 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196006075 NAD binding site [chemical binding]; other site 246196006076 catalytic residues [active] 246196006077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006079 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196006080 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196006081 NAD(P) binding site [chemical binding]; other site 246196006082 catalytic residues [active] 246196006083 acyl-CoA synthetase; Validated; Region: PRK07798 246196006084 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006085 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 246196006086 acyl-activating enzyme (AAE) consensus motif; other site 246196006087 acyl-activating enzyme (AAE) consensus motif; other site 246196006088 putative AMP binding site [chemical binding]; other site 246196006089 putative active site [active] 246196006090 putative CoA binding site [chemical binding]; other site 246196006091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246196006092 catalytic triad [active] 246196006093 conserved cis-peptide bond; other site 246196006094 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196006095 [2Fe-2S] cluster binding site [ion binding]; other site 246196006096 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196006097 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196006098 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 246196006099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006100 NAD(P) binding site [chemical binding]; other site 246196006101 active site 246196006102 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 246196006103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196006104 PAS domain; Region: PAS_9; pfam13426 246196006105 putative active site [active] 246196006106 heme pocket [chemical binding]; other site 246196006107 GAF domain; Region: GAF; pfam01590 246196006108 Histidine kinase; Region: HisKA_3; pfam07730 246196006109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196006110 ATP binding site [chemical binding]; other site 246196006111 Mg2+ binding site [ion binding]; other site 246196006112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196006113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196006114 active site 246196006115 phosphorylation site [posttranslational modification] 246196006116 intermolecular recognition site; other site 246196006117 dimerization interface [polypeptide binding]; other site 246196006118 hypothetical protein; Provisional; Region: PRK06834 246196006119 FAD binding domain; Region: FAD_binding_3; pfam01494 246196006120 Cupin; Region: Cupin_1; smart00835 246196006121 Cupin; Region: Cupin_1; smart00835 246196006122 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196006123 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196006124 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196006125 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196006126 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196006127 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196006128 Protein of unknown function (DUF466); Region: DUF466; pfam04328 246196006129 carbon starvation protein A; Provisional; Region: PRK15015 246196006130 Carbon starvation protein CstA; Region: CstA; pfam02554 246196006131 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 246196006132 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 246196006133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196006134 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196006135 Uncharacterized conserved protein [Function unknown]; Region: COG2427 246196006136 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 246196006137 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 246196006138 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 246196006139 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 246196006140 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 246196006141 nickel binding site [ion binding]; other site 246196006142 NifU-like domain; Region: NifU; cl00484 246196006143 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 246196006144 iron-sulfur cluster [ion binding]; other site 246196006145 [2Fe-2S] cluster binding site [ion binding]; other site 246196006146 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196006147 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 246196006148 Acylphosphatase; Region: Acylphosphatase; pfam00708 246196006149 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 246196006150 HypF finger; Region: zf-HYPF; pfam07503 246196006151 HypF finger; Region: zf-HYPF; pfam07503 246196006152 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 246196006153 HupF/HypC family; Region: HupF_HypC; pfam01455 246196006154 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 246196006155 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 246196006156 dimerization interface [polypeptide binding]; other site 246196006157 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 246196006158 ATP binding site [chemical binding]; other site 246196006159 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 246196006160 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 246196006161 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 246196006162 active site 246196006163 DNA binding site [nucleotide binding] 246196006164 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 246196006165 DNA binding site [nucleotide binding] 246196006166 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 246196006167 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 246196006168 Moco binding site; other site 246196006169 metal coordination site [ion binding]; other site 246196006170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196006171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006172 NAD(P) binding site [chemical binding]; other site 246196006173 active site 246196006174 pyruvate dehydrogenase; Provisional; Region: PRK09124 246196006175 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246196006176 PYR/PP interface [polypeptide binding]; other site 246196006177 dimer interface [polypeptide binding]; other site 246196006178 tetramer interface [polypeptide binding]; other site 246196006179 TPP binding site [chemical binding]; other site 246196006180 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196006181 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 246196006182 TPP-binding site [chemical binding]; other site 246196006183 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196006184 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196006185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196006186 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196006187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006188 S-adenosylmethionine binding site [chemical binding]; other site 246196006189 Phosphotransferase enzyme family; Region: APH; pfam01636 246196006190 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196006191 putative active site [active] 246196006192 putative substrate binding site [chemical binding]; other site 246196006193 ATP binding site [chemical binding]; other site 246196006194 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196006195 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 246196006196 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196006197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006199 short chain dehydrogenase; Provisional; Region: PRK05650 246196006200 short chain dehydrogenase; Provisional; Region: PRK07832 246196006201 NAD(P) binding site [chemical binding]; other site 246196006202 active site 246196006203 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 246196006204 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 246196006205 dimer interface [polypeptide binding]; other site 246196006206 active site 246196006207 Predicted ATPase [General function prediction only]; Region: COG4637 246196006208 AAA domain; Region: AAA_23; pfam13476 246196006209 Walker A/P-loop; other site 246196006210 ATP binding site [chemical binding]; other site 246196006211 ABC transporter signature motif; other site 246196006212 AAA domain; Region: AAA_21; pfam13304 246196006213 Walker B; other site 246196006214 D-loop; other site 246196006215 H-loop/switch region; other site 246196006216 DNA polymerase IV; Validated; Region: PRK03352 246196006217 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246196006218 active site 246196006219 DNA binding site [nucleotide binding] 246196006220 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006222 Predicted flavoprotein [General function prediction only]; Region: COG0431 246196006223 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 246196006224 catalytic residues [active] 246196006225 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 246196006226 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 246196006227 Class I ribonucleotide reductase; Region: RNR_I; cd01679 246196006228 active site 246196006229 dimer interface [polypeptide binding]; other site 246196006230 catalytic residues [active] 246196006231 effector binding site; other site 246196006232 R2 peptide binding site; other site 246196006233 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 246196006234 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246196006235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006236 putative substrate translocation pore; other site 246196006237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 246196006238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196006239 Coenzyme A binding pocket [chemical binding]; other site 246196006240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006242 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196006243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196006244 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246196006245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006247 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196006248 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196006249 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196006250 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 246196006251 dimer interface [polypeptide binding]; other site 246196006252 putative radical transfer pathway; other site 246196006253 diiron center [ion binding]; other site 246196006254 tyrosyl radical; other site 246196006255 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196006256 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246196006257 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196006258 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 246196006259 putative NAD(P) binding site [chemical binding]; other site 246196006260 putative substrate binding site [chemical binding]; other site 246196006261 catalytic Zn binding site [ion binding]; other site 246196006262 structural Zn binding site [ion binding]; other site 246196006263 dimer interface [polypeptide binding]; other site 246196006264 YCII-related domain; Region: YCII; cl00999 246196006265 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196006266 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246196006267 intersubunit interface [polypeptide binding]; other site 246196006268 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 246196006269 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246196006270 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 246196006271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196006272 motif II; other site 246196006273 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196006274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006275 DNA-binding site [nucleotide binding]; DNA binding site 246196006276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196006277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196006278 homodimer interface [polypeptide binding]; other site 246196006279 catalytic residue [active] 246196006280 Predicted membrane protein [Function unknown]; Region: COG2364 246196006281 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 246196006282 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 246196006283 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 246196006284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196006285 Walker A/P-loop; other site 246196006286 ATP binding site [chemical binding]; other site 246196006287 Q-loop/lid; other site 246196006288 ABC transporter signature motif; other site 246196006289 Walker B; other site 246196006290 D-loop; other site 246196006291 H-loop/switch region; other site 246196006292 NUDIX domain; Region: NUDIX; pfam00293 246196006293 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196006294 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196006295 substrate binding site [chemical binding]; other site 246196006296 oxyanion hole (OAH) forming residues; other site 246196006297 trimer interface [polypeptide binding]; other site 246196006298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006299 S-adenosylmethionine binding site [chemical binding]; other site 246196006300 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 246196006301 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 246196006302 FOG: WD40-like repeat [Function unknown]; Region: COG1520 246196006303 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196006304 active site 246196006305 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 246196006306 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 246196006307 trimer interface [polypeptide binding]; other site 246196006308 active site 246196006309 substrate binding site [chemical binding]; other site 246196006310 CoA binding site [chemical binding]; other site 246196006311 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 246196006312 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 246196006313 homotetramer interface [polypeptide binding]; other site 246196006314 FMN binding site [chemical binding]; other site 246196006315 homodimer contacts [polypeptide binding]; other site 246196006316 putative active site [active] 246196006317 putative substrate binding site [chemical binding]; other site 246196006318 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196006319 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196006320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196006321 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196006322 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246196006323 phosphate binding site [ion binding]; other site 246196006324 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196006325 glycosyltransferase, MGT family; Region: MGT; TIGR01426 246196006326 active site 246196006327 TDP-binding site; other site 246196006328 acceptor substrate-binding pocket; other site 246196006329 homodimer interface [polypeptide binding]; other site 246196006330 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 246196006331 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246196006332 [2Fe-2S] cluster binding site [ion binding]; other site 246196006333 iron-sulfur cluster [ion binding]; other site 246196006334 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 246196006335 myosin-cross-reactive antigen; Provisional; Region: PRK13977 246196006336 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 246196006337 active site lid residues [active] 246196006338 substrate binding pocket [chemical binding]; other site 246196006339 catalytic residues [active] 246196006340 substrate-Mg2+ binding site; other site 246196006341 aspartate-rich region 1; other site 246196006342 aspartate-rich region 2; other site 246196006343 phytoene desaturase; Region: crtI_fam; TIGR02734 246196006344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196006345 Uncharacterized conserved protein [Function unknown]; Region: COG1543 246196006346 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 246196006347 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 246196006348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006349 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196006350 S-adenosylmethionine binding site [chemical binding]; other site 246196006351 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 246196006352 Ligand binding site [chemical binding]; other site 246196006353 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 246196006354 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 246196006355 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 246196006356 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196006357 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196006358 NAD(P) binding site [chemical binding]; other site 246196006359 active site 246196006360 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 246196006361 putative FMN binding site [chemical binding]; other site 246196006362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 246196006363 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196006364 putative acyl-acceptor binding pocket; other site 246196006365 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 246196006366 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 246196006367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196006368 catalytic residue [active] 246196006369 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 246196006370 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 246196006371 Ligand Binding Site [chemical binding]; other site 246196006372 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 246196006373 4-coumarate--CoA ligase; Region: PLN02246 246196006374 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 246196006375 acyl-activating enzyme (AAE) consensus motif; other site 246196006376 active site 246196006377 putative CoA binding site [chemical binding]; other site 246196006378 AMP binding site [chemical binding]; other site 246196006379 YjbR; Region: YjbR; pfam04237 246196006380 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 246196006381 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 246196006382 nucleotide binding pocket [chemical binding]; other site 246196006383 K-X-D-G motif; other site 246196006384 catalytic site [active] 246196006385 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 246196006386 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 246196006387 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 246196006388 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 246196006389 Dimer interface [polypeptide binding]; other site 246196006390 BRCT sequence motif; other site 246196006391 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246196006392 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 246196006393 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 246196006394 6-phosphofructokinase; Provisional; Region: PRK03202 246196006395 active site 246196006396 ADP/pyrophosphate binding site [chemical binding]; other site 246196006397 dimerization interface [polypeptide binding]; other site 246196006398 allosteric effector site; other site 246196006399 fructose-1,6-bisphosphate binding site; other site 246196006400 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 246196006401 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 246196006402 GatB domain; Region: GatB_Yqey; smart00845 246196006403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006405 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 246196006406 Predicted membrane protein [Function unknown]; Region: COG2259 246196006407 Bacterial PH domain; Region: bPH_6; pfam10756 246196006408 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 246196006409 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196006410 PYR/PP interface [polypeptide binding]; other site 246196006411 dimer interface [polypeptide binding]; other site 246196006412 TPP binding site [chemical binding]; other site 246196006413 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196006414 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 246196006415 TPP-binding site [chemical binding]; other site 246196006416 dimer interface [polypeptide binding]; other site 246196006417 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 246196006418 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 246196006419 putative valine binding site [chemical binding]; other site 246196006420 dimer interface [polypeptide binding]; other site 246196006421 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 246196006422 ketol-acid reductoisomerase; Provisional; Region: PRK05479 246196006423 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 246196006424 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 246196006425 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 246196006426 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246196006427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196006428 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 246196006429 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 246196006430 ligand binding site [chemical binding]; other site 246196006431 NAD binding site [chemical binding]; other site 246196006432 dimerization interface [polypeptide binding]; other site 246196006433 catalytic site [active] 246196006434 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 246196006435 putative L-serine binding site [chemical binding]; other site 246196006436 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 246196006437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196006439 putative substrate translocation pore; other site 246196006440 Secretory lipase; Region: LIP; pfam03583 246196006441 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196006442 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 246196006443 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196006444 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196006445 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 246196006446 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 246196006447 active site 246196006448 HIGH motif; other site 246196006449 KMSKS motif; other site 246196006450 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196006451 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196006452 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196006453 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 246196006454 substrate binding site [chemical binding]; other site 246196006455 ligand binding site [chemical binding]; other site 246196006456 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 246196006457 substrate binding site [chemical binding]; other site 246196006458 histone-like DNA-binding protein HU; Region: HU; cd13831 246196006459 dimer interface [polypeptide binding]; other site 246196006460 DNA binding site [nucleotide binding] 246196006461 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 246196006462 active site 246196006463 Ap6A binding site [chemical binding]; other site 246196006464 nudix motif; other site 246196006465 metal binding site [ion binding]; metal-binding site 246196006466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196006467 catalytic core [active] 246196006468 polyphosphate kinase; Provisional; Region: PRK05443 246196006469 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 246196006470 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 246196006471 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 246196006472 putative domain interface [polypeptide binding]; other site 246196006473 putative active site [active] 246196006474 catalytic site [active] 246196006475 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246196006476 putative active site [active] 246196006477 catalytic site [active] 246196006478 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 246196006479 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 246196006480 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 246196006481 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 246196006482 cystathionine gamma-lyase; Validated; Region: PRK07582 246196006483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196006484 catalytic residue [active] 246196006485 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 246196006486 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 246196006487 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 246196006488 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 246196006489 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196006490 AsnC family; Region: AsnC_trans_reg; pfam01037 246196006491 thiamine monophosphate kinase; Provisional; Region: PRK05731 246196006492 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 246196006493 ATP binding site [chemical binding]; other site 246196006494 dimerization interface [polypeptide binding]; other site 246196006495 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 246196006496 ligand binding site [chemical binding]; other site 246196006497 active site 246196006498 UGI interface [polypeptide binding]; other site 246196006499 catalytic site [active] 246196006500 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 246196006501 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 246196006502 DAK2 domain; Region: Dak2; pfam02734 246196006503 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 246196006504 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 246196006505 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 246196006506 generic binding surface II; other site 246196006507 ssDNA binding site; other site 246196006508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196006509 ATP binding site [chemical binding]; other site 246196006510 putative Mg++ binding site [ion binding]; other site 246196006511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196006512 nucleotide binding region [chemical binding]; other site 246196006513 ATP-binding site [chemical binding]; other site 246196006514 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 246196006515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 246196006516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196006517 Coenzyme A binding pocket [chemical binding]; other site 246196006518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196006521 active site 246196006522 catalytic tetrad [active] 246196006523 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196006524 active site 246196006525 catalytic tetrad [active] 246196006526 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196006527 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196006528 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246196006529 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 246196006530 catalytic residues [active] 246196006531 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 246196006532 putative active site [active] 246196006533 redox center [active] 246196006534 pyruvate carboxylase; Reviewed; Region: PRK12999 246196006535 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196006536 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196006537 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196006538 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 246196006539 active site 246196006540 catalytic residues [active] 246196006541 metal binding site [ion binding]; metal-binding site 246196006542 homodimer binding site [polypeptide binding]; other site 246196006543 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 246196006544 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196006545 carboxyltransferase (CT) interaction site; other site 246196006546 biotinylation site [posttranslational modification]; other site 246196006547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006548 S-adenosylmethionine binding site [chemical binding]; other site 246196006549 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 246196006550 active site 246196006551 (T/H)XGH motif; other site 246196006552 Hemerythrin-like domain; Region: Hr-like; cd12108 246196006553 Fe binding site [ion binding]; other site 246196006554 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 246196006555 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 246196006556 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 246196006557 ribonuclease III; Reviewed; Region: rnc; PRK00102 246196006558 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 246196006559 dimerization interface [polypeptide binding]; other site 246196006560 active site 246196006561 metal binding site [ion binding]; metal-binding site 246196006562 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 246196006563 dsRNA binding site [nucleotide binding]; other site 246196006564 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 246196006565 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 246196006566 DNA binding site [nucleotide binding] 246196006567 catalytic residue [active] 246196006568 H2TH interface [polypeptide binding]; other site 246196006569 putative catalytic residues [active] 246196006570 turnover-facilitating residue; other site 246196006571 intercalation triad [nucleotide binding]; other site 246196006572 8OG recognition residue [nucleotide binding]; other site 246196006573 putative reading head residues; other site 246196006574 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246196006575 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246196006576 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 246196006577 acylphosphatase; Provisional; Region: PRK14422 246196006578 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 246196006579 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 246196006580 Walker A/P-loop; other site 246196006581 ATP binding site [chemical binding]; other site 246196006582 Mitochondrial ribosomal protein L28; Region: MRP-L28; pfam09812 246196006583 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 246196006584 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 246196006585 ABC transporter signature motif; other site 246196006586 Walker B; other site 246196006587 D-loop; other site 246196006588 H-loop/switch region; other site 246196006589 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 246196006590 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 246196006591 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 246196006592 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 246196006593 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 246196006594 PII uridylyl-transferase; Provisional; Region: PRK03381 246196006595 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246196006596 metal binding triad; other site 246196006597 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 246196006598 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196006599 Zn2+ binding site [ion binding]; other site 246196006600 Mg2+ binding site [ion binding]; other site 246196006601 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 246196006602 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246196006603 Helix-turn-helix domain; Region: HTH_31; pfam13560 246196006604 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196006605 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196006606 active site 246196006607 catalytic tetrad [active] 246196006608 signal recognition particle protein; Provisional; Region: PRK10867 246196006609 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 246196006610 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 246196006611 P loop; other site 246196006612 GTP binding site [chemical binding]; other site 246196006613 Signal peptide binding domain; Region: SRP_SPB; pfam02978 246196006614 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196006615 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196006616 active site 246196006617 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 246196006618 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 246196006619 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 246196006620 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 246196006621 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 246196006622 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 246196006623 ribosomal protein S16; Region: S16; TIGR00002 246196006624 hypothetical protein; Provisional; Region: PRK02821 246196006625 G-X-X-G motif; other site 246196006626 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 246196006627 RimM N-terminal domain; Region: RimM; pfam01782 246196006628 PRC-barrel domain; Region: PRC; pfam05239 246196006629 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 246196006630 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 246196006631 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 246196006632 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 246196006633 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 246196006634 Catalytic site [active] 246196006635 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 246196006636 RNA/DNA hybrid binding site [nucleotide binding]; other site 246196006637 active site 246196006638 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 246196006639 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246196006640 hypothetical protein; Validated; Region: PRK00029 246196006641 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 246196006642 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196006643 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196006644 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 246196006645 tetrameric interface [polypeptide binding]; other site 246196006646 NAD binding site [chemical binding]; other site 246196006647 catalytic residues [active] 246196006648 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196006649 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196006650 inhibitor-cofactor binding pocket; inhibition site 246196006651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196006652 catalytic residue [active] 246196006653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196006654 UMP phosphatase; Provisional; Region: PRK10444 246196006655 active site 246196006656 motif I; other site 246196006657 motif II; other site 246196006658 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196006659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006660 DNA-binding site [nucleotide binding]; DNA binding site 246196006661 FCD domain; Region: FCD; pfam07729 246196006662 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246196006663 homotrimer interaction site [polypeptide binding]; other site 246196006664 putative active site [active] 246196006665 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 246196006666 putative hydrophobic ligand binding site [chemical binding]; other site 246196006667 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196006668 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196006669 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196006670 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196006671 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196006672 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196006673 Walker A/P-loop; other site 246196006674 ATP binding site [chemical binding]; other site 246196006675 Q-loop/lid; other site 246196006676 ABC transporter signature motif; other site 246196006677 Walker B; other site 246196006678 D-loop; other site 246196006679 H-loop/switch region; other site 246196006680 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196006681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196006682 dimer interface [polypeptide binding]; other site 246196006683 conserved gate region; other site 246196006684 putative PBP binding loops; other site 246196006685 ABC-ATPase subunit interface; other site 246196006686 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196006687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196006688 dimer interface [polypeptide binding]; other site 246196006689 conserved gate region; other site 246196006690 putative PBP binding loops; other site 246196006691 ABC-ATPase subunit interface; other site 246196006692 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196006693 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196006694 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196006695 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196006696 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 246196006697 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 246196006698 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196006699 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196006700 catalytic loop [active] 246196006701 iron binding site [ion binding]; other site 246196006702 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196006703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196006704 Amidohydrolase; Region: Amidohydro_4; pfam13147 246196006705 active site 246196006706 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196006707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196006708 active site 246196006709 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196006710 TPP-binding site [chemical binding]; other site 246196006711 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 246196006712 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 246196006713 PYR/PP interface [polypeptide binding]; other site 246196006714 dimer interface [polypeptide binding]; other site 246196006715 TPP binding site [chemical binding]; other site 246196006716 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196006717 CoA-transferase family III; Region: CoA_transf_3; cl19215 246196006718 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196006719 acyl-CoA thioesterase II; Region: tesB; TIGR00189 246196006720 active site 246196006721 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196006722 catalytic triad [active] 246196006723 dimer interface [polypeptide binding]; other site 246196006724 AMP-binding enzyme; Region: AMP-binding; pfam00501 246196006725 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196006726 acyl-activating enzyme (AAE) consensus motif; other site 246196006727 AMP binding site [chemical binding]; other site 246196006728 active site 246196006729 CoA binding site [chemical binding]; other site 246196006730 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196006731 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246196006732 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196006733 transketolase; Reviewed; Region: PRK05899 246196006734 TPP-binding site [chemical binding]; other site 246196006735 PYR/PP interface [polypeptide binding]; other site 246196006736 dimer interface [polypeptide binding]; other site 246196006737 TPP binding site [chemical binding]; other site 246196006738 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 246196006739 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196006740 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196006741 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 246196006742 putative DNA binding site [nucleotide binding]; other site 246196006743 putative Zn2+ binding site [ion binding]; other site 246196006744 Cutinase; Region: Cutinase; pfam01083 246196006745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196006746 active site 246196006747 catalytic tetrad [active] 246196006748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196006749 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196006750 putative DNA binding site [nucleotide binding]; other site 246196006751 putative Zn2+ binding site [ion binding]; other site 246196006752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006753 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196006754 NAD(P) binding site [chemical binding]; other site 246196006755 active site 246196006756 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246196006757 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196006758 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196006759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196006760 DNA-binding site [nucleotide binding]; DNA binding site 246196006761 FCD domain; Region: FCD; pfam07729 246196006762 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 246196006763 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196006764 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196006765 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196006766 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 246196006767 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196006768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006769 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196006770 putative substrate translocation pore; other site 246196006771 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196006772 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196006773 inhibitor-cofactor binding pocket; inhibition site 246196006774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196006775 catalytic residue [active] 246196006776 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 246196006777 tetramerization interface [polypeptide binding]; other site 246196006778 NAD(P) binding site [chemical binding]; other site 246196006779 catalytic residues [active] 246196006780 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196006781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006782 DNA-binding site [nucleotide binding]; DNA binding site 246196006783 FCD domain; Region: FCD; pfam07729 246196006784 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196006785 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196006786 FAD binding domain; Region: FAD_binding_4; pfam01565 246196006787 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 246196006788 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 246196006789 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 246196006790 Cysteine-rich domain; Region: CCG; pfam02754 246196006791 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 246196006792 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 246196006793 metal binding site [ion binding]; metal-binding site 246196006794 dimer interface [polypeptide binding]; other site 246196006795 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 246196006796 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196006797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196006798 homodimer interface [polypeptide binding]; other site 246196006799 catalytic residue [active] 246196006800 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 246196006801 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196006802 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246196006803 active site 246196006804 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196006805 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 246196006806 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 246196006807 NAD binding site [chemical binding]; other site 246196006808 ligand binding site [chemical binding]; other site 246196006809 catalytic site [active] 246196006810 putative amidase; Provisional; Region: PRK06169 246196006811 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 246196006812 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 246196006813 active site 246196006814 catalytic triad [active] 246196006815 oxyanion hole [active] 246196006816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196006817 putative PBP binding loops; other site 246196006818 dimer interface [polypeptide binding]; other site 246196006819 ABC-ATPase subunit interface; other site 246196006820 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196006821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196006822 dimer interface [polypeptide binding]; other site 246196006823 conserved gate region; other site 246196006824 putative PBP binding loops; other site 246196006825 ABC-ATPase subunit interface; other site 246196006826 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196006827 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196006828 Walker A/P-loop; other site 246196006829 ATP binding site [chemical binding]; other site 246196006830 Q-loop/lid; other site 246196006831 ABC transporter signature motif; other site 246196006832 Walker B; other site 246196006833 D-loop; other site 246196006834 H-loop/switch region; other site 246196006835 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196006836 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196006837 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 246196006838 substrate binding site [chemical binding]; other site 246196006839 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246196006840 substrate binding site [chemical binding]; other site 246196006841 ligand binding site [chemical binding]; other site 246196006842 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196006843 tetramer interface [polypeptide binding]; other site 246196006844 active site 246196006845 Mg2+/Mn2+ binding site [ion binding]; other site 246196006846 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196006847 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196006848 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196006849 hypothetical protein; Reviewed; Region: PRK12497 246196006850 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 246196006851 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 246196006852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196006853 Walker A motif; other site 246196006854 ATP binding site [chemical binding]; other site 246196006855 Walker B motif; other site 246196006856 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 246196006857 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 246196006858 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246196006859 FAD binding pocket [chemical binding]; other site 246196006860 FAD binding motif [chemical binding]; other site 246196006861 phosphate binding motif [ion binding]; other site 246196006862 NAD binding pocket [chemical binding]; other site 246196006863 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 246196006864 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 246196006865 putative active site [active] 246196006866 putative substrate binding site [chemical binding]; other site 246196006867 putative FMN binding site [chemical binding]; other site 246196006868 putative catalytic residues [active] 246196006869 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 246196006870 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196006871 active site 246196006872 DNA binding site [nucleotide binding] 246196006873 Int/Topo IB signature motif; other site 246196006874 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196006875 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196006876 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196006877 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 246196006878 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246196006879 Peptidase family M23; Region: Peptidase_M23; pfam01551 246196006880 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 246196006881 rRNA interaction site [nucleotide binding]; other site 246196006882 S8 interaction site; other site 246196006883 putative laminin-1 binding site; other site 246196006884 elongation factor Ts; Provisional; Region: tsf; PRK09377 246196006885 UBA/TS-N domain; Region: UBA; pfam00627 246196006886 amidase; Provisional; Region: PRK07869 246196006887 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246196006888 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246196006889 FtsX-like permease family; Region: FtsX; pfam02687 246196006890 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246196006891 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246196006892 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246196006893 Walker A/P-loop; other site 246196006894 ATP binding site [chemical binding]; other site 246196006895 Q-loop/lid; other site 246196006896 ABC transporter signature motif; other site 246196006897 Walker B; other site 246196006898 D-loop; other site 246196006899 H-loop/switch region; other site 246196006900 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196006901 tyramine oxidase; Provisional; Region: tynA; PRK11504 246196006902 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 246196006903 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 246196006904 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 246196006905 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 246196006906 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 246196006907 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 246196006908 dimerization interface [polypeptide binding]; other site 246196006909 ligand binding site [chemical binding]; other site 246196006910 NADP binding site [chemical binding]; other site 246196006911 catalytic site [active] 246196006912 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 246196006913 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196006914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196006915 DNA-binding site [nucleotide binding]; DNA binding site 246196006916 FCD domain; Region: FCD; pfam07729 246196006917 Dehydroquinase class II; Region: DHquinase_II; pfam01220 246196006918 trimer interface [polypeptide binding]; other site 246196006919 active site 246196006920 SCP-2 sterol transfer family; Region: SCP2; cl01225 246196006921 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196006922 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196006923 short chain dehydrogenase; Provisional; Region: PRK06138 246196006924 classical (c) SDRs; Region: SDR_c; cd05233 246196006925 NAD(P) binding site [chemical binding]; other site 246196006926 active site 246196006927 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196006928 classical (c) SDRs; Region: SDR_c; cd05233 246196006929 NAD(P) binding site [chemical binding]; other site 246196006930 active site 246196006931 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 246196006932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006933 putative substrate translocation pore; other site 246196006934 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196006935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196006936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196006937 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196006938 S-adenosylmethionine binding site [chemical binding]; other site 246196006939 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 246196006940 putative nucleotide binding site [chemical binding]; other site 246196006941 uridine monophosphate binding site [chemical binding]; other site 246196006942 homohexameric interface [polypeptide binding]; other site 246196006943 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 246196006944 hinge region; other site 246196006945 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 246196006946 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246196006947 EamA-like transporter family; Region: EamA; pfam00892 246196006948 EamA-like transporter family; Region: EamA; pfam00892 246196006949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196006950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196006951 dimerization interface [polypeptide binding]; other site 246196006952 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 246196006953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196006954 FeS/SAM binding site; other site 246196006955 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196006956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196006957 DNA-binding site [nucleotide binding]; DNA binding site 246196006958 FCD domain; Region: FCD; pfam07729 246196006959 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196006960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246196006961 DNA binding residues [nucleotide binding] 246196006962 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196006963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196006964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196006965 NAD(P) binding site [chemical binding]; other site 246196006966 active site 246196006967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196006968 D-galactonate transporter; Region: 2A0114; TIGR00893 246196006969 putative substrate translocation pore; other site 246196006970 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 246196006971 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 246196006972 NAD binding site [chemical binding]; other site 246196006973 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196006974 NAD binding site [chemical binding]; other site 246196006975 catalytic residues [active] 246196006976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006978 Ecdysteroid kinase; Region: EcKinase; cl17738 246196006979 Phosphotransferase enzyme family; Region: APH; pfam01636 246196006980 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 246196006981 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 246196006982 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 246196006983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196006984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196006985 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196006986 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196006987 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196006988 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196006989 Strictosidine synthase; Region: Str_synth; cl19733 246196006990 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196006991 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196006992 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196006993 NAD(P) binding site [chemical binding]; other site 246196006994 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 246196006995 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196006996 classical (c) SDRs; Region: SDR_c; cd05233 246196006997 NAD(P) binding site [chemical binding]; other site 246196006998 active site 246196006999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196007000 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196007001 Src Homology 3 domain superfamily; Region: SH3; cl17036 246196007002 peptide ligand binding site [polypeptide binding]; other site 246196007003 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196007004 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196007005 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196007006 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196007007 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196007008 Sulfate transporter family; Region: Sulfate_transp; cl19250 246196007009 xanthine permease; Region: pbuX; TIGR03173 246196007010 Cupin domain; Region: Cupin_2; cl17218 246196007011 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246196007012 hydrophobic ligand binding site; other site 246196007013 Domain of unknown function (DUF427); Region: DUF427; pfam04248 246196007014 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 246196007015 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 246196007016 DNA photolyase; Region: DNA_photolyase; pfam00875 246196007017 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 246196007018 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 246196007019 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 246196007020 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 246196007021 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 246196007022 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 246196007023 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 246196007024 active site 246196007025 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 246196007026 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 246196007027 putative substrate binding region [chemical binding]; other site 246196007028 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 246196007029 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 246196007030 Predicted acetyltransferase [General function prediction only]; Region: COG3393 246196007031 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 246196007032 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 246196007033 putative catalytic residues [active] 246196007034 tetracycline repressor protein TetR; Provisional; Region: PRK13756 246196007035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196007036 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196007037 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 246196007038 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196007039 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196007040 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196007041 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196007042 CoenzymeA binding site [chemical binding]; other site 246196007043 subunit interaction site [polypeptide binding]; other site 246196007044 PHB binding site; other site 246196007045 methionine aminopeptidase; Provisional; Region: PRK12318 246196007046 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246196007047 active site 246196007048 cobyric acid synthase; Provisional; Region: PRK00784 246196007049 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196007050 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 246196007051 catalytic triad [active] 246196007052 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 246196007053 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 246196007054 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246196007055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196007056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196007057 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196007058 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 246196007059 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196007060 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196007061 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 246196007062 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 246196007063 active site 246196007064 dimer interface [polypeptide binding]; other site 246196007065 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 246196007066 Ligand Binding Site [chemical binding]; other site 246196007067 Molecular Tunnel; other site 246196007068 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196007069 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246196007070 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196007071 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 246196007072 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 246196007073 catalytic triad [active] 246196007074 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 246196007075 NAD(P) binding site [chemical binding]; other site 246196007076 catalytic residues [active] 246196007077 short chain dehydrogenase; Provisional; Region: PRK06057 246196007078 classical (c) SDRs; Region: SDR_c; cd05233 246196007079 NAD(P) binding site [chemical binding]; other site 246196007080 active site 246196007081 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007083 DNA-binding site [nucleotide binding]; DNA binding site 246196007084 FCD domain; Region: FCD; pfam07729 246196007085 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196007086 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196007087 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196007088 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 246196007089 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 246196007090 active site 246196007091 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 246196007092 heterodimer interface [polypeptide binding]; other site 246196007093 active site 246196007094 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 246196007095 tetramer interface [polypeptide binding]; other site 246196007096 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246196007097 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007099 DNA-binding site [nucleotide binding]; DNA binding site 246196007100 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196007101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196007102 dimerization interface [polypeptide binding]; other site 246196007103 putative DNA binding site [nucleotide binding]; other site 246196007104 putative Zn2+ binding site [ion binding]; other site 246196007105 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 246196007106 PDGLE domain; Region: PDGLE; pfam13190 246196007107 Cobalt transport protein; Region: CbiQ; cl00463 246196007108 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196007109 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196007110 Walker A/P-loop; other site 246196007111 ATP binding site [chemical binding]; other site 246196007112 Q-loop/lid; other site 246196007113 ABC transporter signature motif; other site 246196007114 Walker B; other site 246196007115 D-loop; other site 246196007116 H-loop/switch region; other site 246196007117 mycothione reductase; Reviewed; Region: PRK07846 246196007118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196007119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196007120 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 246196007121 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246196007122 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196007123 malate:quinone oxidoreductase; Validated; Region: PRK05257 246196007124 Predicted dehydrogenase [General function prediction only]; Region: COG0579 246196007125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196007126 Coenzyme A binding pocket [chemical binding]; other site 246196007127 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 246196007128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196007129 Walker A motif; other site 246196007130 ATP binding site [chemical binding]; other site 246196007131 Walker B motif; other site 246196007132 arginine finger; other site 246196007133 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 246196007134 metal ion-dependent adhesion site (MIDAS); other site 246196007135 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 246196007136 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 246196007137 Walker A motif; other site 246196007138 homodimer interface [polypeptide binding]; other site 246196007139 ATP binding site [chemical binding]; other site 246196007140 hydroxycobalamin binding site [chemical binding]; other site 246196007141 Walker B motif; other site 246196007142 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 246196007143 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196007144 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 246196007145 catalytic triad [active] 246196007146 siroheme synthase; Provisional; Region: cysG; PRK10637 246196007147 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 246196007148 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 246196007149 active site 246196007150 SAM binding site [chemical binding]; other site 246196007151 homodimer interface [polypeptide binding]; other site 246196007152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196007154 putative substrate translocation pore; other site 246196007155 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 246196007156 prolyl-tRNA synthetase; Provisional; Region: PRK09194 246196007157 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 246196007158 dimer interface [polypeptide binding]; other site 246196007159 motif 1; other site 246196007160 active site 246196007161 motif 2; other site 246196007162 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 246196007163 putative deacylase active site [active] 246196007164 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 246196007165 anticodon binding site; other site 246196007166 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246196007167 dinuclear metal binding motif [ion binding]; other site 246196007168 Sm and related proteins; Region: Sm_like; cl00259 246196007169 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 246196007170 putative oligomer interface [polypeptide binding]; other site 246196007171 putative RNA binding site [nucleotide binding]; other site 246196007172 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 246196007173 NusA N-terminal domain; Region: NusA_N; pfam08529 246196007174 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 246196007175 RNA binding site [nucleotide binding]; other site 246196007176 homodimer interface [polypeptide binding]; other site 246196007177 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 246196007178 G-X-X-G motif; other site 246196007179 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 246196007180 G-X-X-G motif; other site 246196007181 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 246196007182 putative RNA binding cleft [nucleotide binding]; other site 246196007183 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246196007184 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 246196007185 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 246196007186 G1 box; other site 246196007187 putative GEF interaction site [polypeptide binding]; other site 246196007188 GTP/Mg2+ binding site [chemical binding]; other site 246196007189 Switch I region; other site 246196007190 G2 box; other site 246196007191 G3 box; other site 246196007192 Switch II region; other site 246196007193 G4 box; other site 246196007194 G5 box; other site 246196007195 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 246196007196 Translation-initiation factor 2; Region: IF-2; pfam11987 246196007197 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 246196007198 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 246196007199 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 246196007200 DHH family; Region: DHH; pfam01368 246196007201 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 246196007202 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 246196007203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196007204 S-adenosylmethionine binding site [chemical binding]; other site 246196007205 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196007206 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196007207 Walker A/P-loop; other site 246196007208 ATP binding site [chemical binding]; other site 246196007209 Q-loop/lid; other site 246196007210 ABC transporter signature motif; other site 246196007211 Walker B; other site 246196007212 D-loop; other site 246196007213 H-loop/switch region; other site 246196007214 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196007215 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196007216 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196007217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007218 dimer interface [polypeptide binding]; other site 246196007219 conserved gate region; other site 246196007220 putative PBP binding loops; other site 246196007221 ABC-ATPase subunit interface; other site 246196007222 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196007223 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196007224 DNA binding site [nucleotide binding] 246196007225 domain linker motif; other site 246196007226 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196007227 dimerization interface [polypeptide binding]; other site 246196007228 ligand binding site [chemical binding]; other site 246196007229 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196007230 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196007231 Protein of unknown function (DUF993); Region: DUF993; pfam06187 246196007232 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196007233 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196007234 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 246196007235 EamA-like transporter family; Region: EamA; pfam00892 246196007236 enoyl-CoA hydratase; Provisional; Region: PRK06190 246196007237 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196007238 substrate binding site [chemical binding]; other site 246196007239 oxyanion hole (OAH) forming residues; other site 246196007240 trimer interface [polypeptide binding]; other site 246196007241 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 246196007242 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 246196007243 Predicted acyl esterases [General function prediction only]; Region: COG2936 246196007244 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196007245 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 246196007246 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196007247 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196007248 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196007249 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 246196007250 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246196007251 active site 246196007252 metal binding site [ion binding]; metal-binding site 246196007253 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 246196007254 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 246196007255 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 246196007256 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 246196007257 RNA binding site [nucleotide binding]; other site 246196007258 active site 246196007259 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 246196007260 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196007261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196007262 active site 246196007263 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196007264 active site 246196007265 dimer interface [polypeptide binding]; other site 246196007266 non-prolyl cis peptide bond; other site 246196007267 insertion regions; other site 246196007268 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 246196007269 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 246196007270 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 246196007271 FeoA domain; Region: FeoA; pfam04023 246196007272 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 246196007273 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 246196007274 active site 246196007275 Riboflavin kinase; Region: Flavokinase; smart00904 246196007276 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 246196007277 16S/18S rRNA binding site [nucleotide binding]; other site 246196007278 S13e-L30e interaction site [polypeptide binding]; other site 246196007279 25S rRNA binding site [nucleotide binding]; other site 246196007280 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 246196007281 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 246196007282 oligomer interface [polypeptide binding]; other site 246196007283 RNA binding site [nucleotide binding]; other site 246196007284 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 246196007285 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 246196007286 RNase E interface [polypeptide binding]; other site 246196007287 trimer interface [polypeptide binding]; other site 246196007288 active site 246196007289 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 246196007290 putative nucleic acid binding region [nucleotide binding]; other site 246196007291 G-X-X-G motif; other site 246196007292 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 246196007293 RNA binding site [nucleotide binding]; other site 246196007294 domain interface; other site 246196007295 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246196007296 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246196007297 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246196007298 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 246196007299 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 246196007300 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 246196007301 hexamer interface [polypeptide binding]; other site 246196007302 ligand binding site [chemical binding]; other site 246196007303 putative active site [active] 246196007304 NAD(P) binding site [chemical binding]; other site 246196007305 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196007306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196007307 putative DNA binding site [nucleotide binding]; other site 246196007308 putative Zn2+ binding site [ion binding]; other site 246196007309 AsnC family; Region: AsnC_trans_reg; pfam01037 246196007310 META domain; Region: META; pfam03724 246196007311 META domain; Region: META; pfam03724 246196007312 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196007313 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196007314 active site 246196007315 dihydrodipicolinate reductase; Provisional; Region: PRK00048 246196007316 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196007317 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 246196007318 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246196007319 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196007320 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246196007321 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 246196007322 dimerization interface [polypeptide binding]; other site 246196007323 active site 246196007324 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 246196007325 folate binding site [chemical binding]; other site 246196007326 NADP+ binding site [chemical binding]; other site 246196007327 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196007328 acyl-activating enzyme (AAE) consensus motif; other site 246196007329 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 246196007330 Helix-turn-helix domain; Region: HTH_38; pfam13936 246196007331 Integrase core domain; Region: rve; pfam00665 246196007332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196007333 Transposase; Region: HTH_Tnp_1; cl17663 246196007334 MMPL family; Region: MMPL; pfam03176 246196007335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 246196007336 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196007337 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196007338 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 246196007339 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196007340 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007342 DNA-binding site [nucleotide binding]; DNA binding site 246196007343 FCD domain; Region: FCD; pfam07729 246196007344 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 246196007345 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 246196007346 dimer interface [polypeptide binding]; other site 246196007347 active site 246196007348 catalytic residue [active] 246196007349 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 246196007350 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196007351 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 246196007352 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196007353 classical (c) SDRs; Region: SDR_c; cd05233 246196007354 NAD(P) binding site [chemical binding]; other site 246196007355 active site 246196007356 Uncharacterized conserved protein [Function unknown]; Region: COG1359 246196007357 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 246196007358 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246196007359 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 246196007360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196007361 Coenzyme A binding pocket [chemical binding]; other site 246196007362 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 246196007363 Competence-damaged protein; Region: CinA; pfam02464 246196007364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196007365 non-specific DNA binding site [nucleotide binding]; other site 246196007366 salt bridge; other site 246196007367 sequence-specific DNA binding site [nucleotide binding]; other site 246196007368 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 246196007369 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196007370 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196007371 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196007372 homodimer interface [polypeptide binding]; other site 246196007373 active site 246196007374 TDP-binding site; other site 246196007375 acceptor substrate-binding pocket; other site 246196007376 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 246196007377 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 246196007378 HupF/HypC family; Region: HupF_HypC; cl00394 246196007379 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 246196007380 dimerization interface [polypeptide binding]; other site 246196007381 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 246196007382 ATP binding site [chemical binding]; other site 246196007383 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 246196007384 dimer interface [polypeptide binding]; other site 246196007385 active site 246196007386 HupF/HypC family; Region: HupF_HypC; cl00394 246196007387 Acylphosphatase; Region: Acylphosphatase; pfam00708 246196007388 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 246196007389 HypF finger; Region: zf-HYPF; pfam07503 246196007390 HypF finger; Region: zf-HYPF; pfam07503 246196007391 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 246196007392 HupF/HypC family; Region: HupF_HypC; pfam01455 246196007393 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 246196007394 nickel binding site [ion binding]; other site 246196007395 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 246196007396 NifU-like domain; Region: NifU; cl00484 246196007397 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196007398 iron-sulfur cluster [ion binding]; other site 246196007399 [2Fe-2S] cluster binding site [ion binding]; other site 246196007400 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 246196007401 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 246196007402 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 246196007403 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196007404 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 246196007405 recombinase A; Provisional; Region: recA; PRK09354 246196007406 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 246196007407 hexamer interface [polypeptide binding]; other site 246196007408 Walker A motif; other site 246196007409 ATP binding site [chemical binding]; other site 246196007410 Walker B motif; other site 246196007411 recombination regulator RecX; Reviewed; Region: recX; PRK00117 246196007412 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196007413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007414 dimer interface [polypeptide binding]; other site 246196007415 conserved gate region; other site 246196007416 putative PBP binding loops; other site 246196007417 ABC-ATPase subunit interface; other site 246196007418 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196007419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007420 dimer interface [polypeptide binding]; other site 246196007421 conserved gate region; other site 246196007422 putative PBP binding loops; other site 246196007423 ABC-ATPase subunit interface; other site 246196007424 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 246196007425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196007426 substrate binding pocket [chemical binding]; other site 246196007427 membrane-bound complex binding site; other site 246196007428 hinge residues; other site 246196007429 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196007430 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196007431 Walker A/P-loop; other site 246196007432 ATP binding site [chemical binding]; other site 246196007433 Q-loop/lid; other site 246196007434 ABC transporter signature motif; other site 246196007435 Walker B; other site 246196007436 D-loop; other site 246196007437 H-loop/switch region; other site 246196007438 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 246196007439 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 246196007440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196007441 FeS/SAM binding site; other site 246196007442 TRAM domain; Region: TRAM; cl01282 246196007443 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 246196007444 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 246196007445 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 246196007446 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 246196007447 active site 246196007448 metal binding site [ion binding]; metal-binding site 246196007449 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 246196007450 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 246196007451 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 246196007452 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 246196007453 GTPases [General function prediction only]; Region: HflX; COG2262 246196007454 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 246196007455 HflX GTPase family; Region: HflX; cd01878 246196007456 G1 box; other site 246196007457 GTP/Mg2+ binding site [chemical binding]; other site 246196007458 Switch I region; other site 246196007459 G2 box; other site 246196007460 G3 box; other site 246196007461 Switch II region; other site 246196007462 G4 box; other site 246196007463 G5 box; other site 246196007464 PE-PPE domain; Region: PE-PPE; pfam08237 246196007465 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196007466 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 246196007467 molybdopterin cofactor binding site; other site 246196007468 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 246196007469 molybdopterin cofactor binding site; other site 246196007470 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 246196007471 LGFP repeat; Region: LGFP; pfam08310 246196007472 LGFP repeat; Region: LGFP; pfam08310 246196007473 LGFP repeat; Region: LGFP; pfam08310 246196007474 LGFP repeat; Region: LGFP; pfam08310 246196007475 LGFP repeat; Region: LGFP; pfam08310 246196007476 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 246196007477 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 246196007478 LexA repressor; Validated; Region: PRK00215 246196007479 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 246196007480 Catalytic site [active] 246196007481 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196007482 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 246196007483 ATP cone domain; Region: ATP-cone; pfam03477 246196007484 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 246196007485 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 246196007486 PAC2 family; Region: PAC2; pfam09754 246196007487 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 246196007488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196007489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196007490 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 246196007491 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 246196007492 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 246196007493 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 246196007494 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 246196007495 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 246196007496 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 246196007497 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 246196007498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196007499 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246196007500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196007501 DNA binding residues [nucleotide binding] 246196007502 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 246196007503 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 246196007504 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 246196007505 Protein of unknown function (DUF952); Region: DUF952; pfam06108 246196007506 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 246196007507 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 246196007508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196007509 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246196007510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196007511 DNA binding residues [nucleotide binding] 246196007512 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196007513 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196007514 nucleotide binding site [chemical binding]; other site 246196007515 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 246196007516 active site 246196007517 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196007518 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 246196007519 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 246196007520 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 246196007521 trimer interface [polypeptide binding]; other site 246196007522 active site 246196007523 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 246196007524 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196007525 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 246196007526 generic binding surface II; other site 246196007527 ssDNA binding site; other site 246196007528 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 246196007529 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 246196007530 TrkA-N domain; Region: TrkA_N; pfam02254 246196007531 TrkA-C domain; Region: TrkA_C; pfam02080 246196007532 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 246196007533 TrkA-N domain; Region: TrkA_N; pfam02254 246196007534 TrkA-C domain; Region: TrkA_C; pfam02080 246196007535 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196007536 TRAM domain; Region: TRAM; pfam01938 246196007537 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 246196007538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196007539 S-adenosylmethionine binding site [chemical binding]; other site 246196007540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196007541 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 246196007542 nucleotidyl binding site; other site 246196007543 metal binding site [ion binding]; metal-binding site 246196007544 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 246196007545 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 246196007546 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 246196007547 TPP-binding site; other site 246196007548 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246196007549 PYR/PP interface [polypeptide binding]; other site 246196007550 dimer interface [polypeptide binding]; other site 246196007551 TPP binding site [chemical binding]; other site 246196007552 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196007553 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196007554 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 246196007555 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 246196007556 catalytic site [active] 246196007557 putative active site [active] 246196007558 putative substrate binding site [chemical binding]; other site 246196007559 Helicase and RNase D C-terminal; Region: HRDC; smart00341 246196007560 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 246196007561 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 246196007562 substrate binding site [chemical binding]; other site 246196007563 active site 246196007564 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 246196007565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196007566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196007567 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 246196007568 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 246196007569 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 246196007570 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196007571 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196007572 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196007573 hypothetical protein; Provisional; Region: PRK14059 246196007574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 246196007575 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 246196007576 Walker A motif; other site 246196007577 ATP binding site [chemical binding]; other site 246196007578 Walker B motif; other site 246196007579 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 246196007580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196007581 Coenzyme A binding pocket [chemical binding]; other site 246196007582 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196007583 Clp amino terminal domain; Region: Clp_N; pfam02861 246196007584 Clp amino terminal domain; Region: Clp_N; pfam02861 246196007585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196007586 HAMP domain; Region: HAMP; pfam00672 246196007587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196007588 dimer interface [polypeptide binding]; other site 246196007589 phosphorylation site [posttranslational modification] 246196007590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196007591 ATP binding site [chemical binding]; other site 246196007592 Mg2+ binding site [ion binding]; other site 246196007593 G-X-G motif; other site 246196007594 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196007595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007596 DNA-binding site [nucleotide binding]; DNA binding site 246196007597 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196007598 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 246196007599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007600 putative substrate translocation pore; other site 246196007601 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 246196007602 gating phenylalanine in ion channel; other site 246196007603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196007604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196007605 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196007606 dimerization interface [polypeptide binding]; other site 246196007607 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 246196007608 LrgA family; Region: LrgA; cl00608 246196007609 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 246196007610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196007611 PAS domain; Region: PAS_9; pfam13426 246196007612 putative active site [active] 246196007613 heme pocket [chemical binding]; other site 246196007614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 246196007615 Histidine kinase; Region: HisKA_3; pfam07730 246196007616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196007617 ATP binding site [chemical binding]; other site 246196007618 Mg2+ binding site [ion binding]; other site 246196007619 G-X-G motif; other site 246196007620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196007621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196007622 phosphorylation site [posttranslational modification] 246196007623 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196007624 Winged helix-turn helix; Region: HTH_29; pfam13551 246196007625 Homeodomain-like domain; Region: HTH_32; pfam13565 246196007626 DDE superfamily endonuclease; Region: DDE_3; cl19249 246196007627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196007628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 246196007629 active site 246196007630 dimerization interface [polypeptide binding]; other site 246196007631 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196007632 DNA binding residues [nucleotide binding] 246196007633 short chain dehydrogenase; Provisional; Region: PRK06180 246196007634 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196007635 NADP binding site [chemical binding]; other site 246196007636 active site 246196007637 steroid binding site; other site 246196007638 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 246196007639 putative hydrophobic ligand binding site [chemical binding]; other site 246196007640 protein interface [polypeptide binding]; other site 246196007641 gate; other site 246196007642 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196007643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007644 putative substrate translocation pore; other site 246196007645 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196007646 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246196007647 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246196007648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196007649 Histidine kinase; Region: HisKA_3; pfam07730 246196007650 putative transposase OrfB; Reviewed; Region: PHA02517 246196007651 HTH-like domain; Region: HTH_21; pfam13276 246196007652 Integrase core domain; Region: rve; pfam00665 246196007653 Integrase core domain; Region: rve_3; pfam13683 246196007654 Transposase; Region: HTH_Tnp_1; cl17663 246196007655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196007656 Suppressor of forked protein (Suf); Region: Suf; pfam05843 246196007657 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196007658 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 246196007659 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196007660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196007661 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196007662 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196007663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196007664 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196007665 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 246196007666 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196007667 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 246196007668 [4Fe-4S] binding site [ion binding]; other site 246196007669 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 246196007670 molybdopterin cofactor binding site; other site 246196007671 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 246196007672 molybdopterin cofactor binding site; other site 246196007673 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 246196007674 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 246196007675 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 246196007676 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 246196007677 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 246196007678 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 246196007679 RNA binding site [nucleotide binding]; other site 246196007680 Uncharacterized conserved protein [Function unknown]; Region: COG0398 246196007681 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196007682 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196007683 active site 246196007684 non-prolyl cis peptide bond; other site 246196007685 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196007686 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196007687 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196007688 Walker A/P-loop; other site 246196007689 ATP binding site [chemical binding]; other site 246196007690 Q-loop/lid; other site 246196007691 ABC transporter signature motif; other site 246196007692 Walker B; other site 246196007693 D-loop; other site 246196007694 H-loop/switch region; other site 246196007695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196007696 Walker A/P-loop; other site 246196007697 ATP binding site [chemical binding]; other site 246196007698 Q-loop/lid; other site 246196007699 ABC transporter signature motif; other site 246196007700 Walker B; other site 246196007701 D-loop; other site 246196007702 H-loop/switch region; other site 246196007703 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196007704 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196007705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007706 dimer interface [polypeptide binding]; other site 246196007707 conserved gate region; other site 246196007708 putative PBP binding loops; other site 246196007709 ABC-ATPase subunit interface; other site 246196007710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196007711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007712 dimer interface [polypeptide binding]; other site 246196007713 conserved gate region; other site 246196007714 putative PBP binding loops; other site 246196007715 ABC-ATPase subunit interface; other site 246196007716 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196007717 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 246196007718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196007720 putative substrate translocation pore; other site 246196007721 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196007722 dimerization interface [polypeptide binding]; other site 246196007723 putative DNA binding site [nucleotide binding]; other site 246196007724 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196007725 putative Zn2+ binding site [ion binding]; other site 246196007726 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196007727 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196007728 classical (c) SDRs; Region: SDR_c; cd05233 246196007729 NAD(P) binding site [chemical binding]; other site 246196007730 active site 246196007731 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196007732 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196007733 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007734 mce related protein; Region: MCE; pfam02470 246196007735 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196007736 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007737 mce related protein; Region: MCE; pfam02470 246196007738 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007739 mce related protein; Region: MCE; pfam02470 246196007740 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007741 mce related protein; Region: MCE; pfam02470 246196007742 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007743 mce related protein; Region: MCE; pfam02470 246196007744 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196007745 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196007746 mce related protein; Region: MCE; pfam02470 246196007747 phage lambda Rz-like lysis protein; Region: PHA00276 246196007748 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196007749 CoenzymeA binding site [chemical binding]; other site 246196007750 subunit interaction site [polypeptide binding]; other site 246196007751 PHB binding site; other site 246196007752 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 246196007753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196007754 Predicted transcriptional regulators [Transcription]; Region: COG1695 246196007755 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 246196007756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196007757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196007758 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196007759 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 246196007760 classical (c) SDRs; Region: SDR_c; cd05233 246196007761 short chain dehydrogenase; Provisional; Region: PRK08267 246196007762 NAD(P) binding site [chemical binding]; other site 246196007763 active site 246196007764 hypothetical protein; Validated; Region: PRK07121 246196007765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196007766 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196007767 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196007768 hypothetical protein; Provisional; Region: PRK06194 246196007769 classical (c) SDRs; Region: SDR_c; cd05233 246196007770 NAD(P) binding site [chemical binding]; other site 246196007771 active site 246196007772 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196007773 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 246196007774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196007775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196007776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196007777 active site 246196007778 enoyl-CoA hydratase; Provisional; Region: PRK09245 246196007779 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196007780 substrate binding site [chemical binding]; other site 246196007781 oxyanion hole (OAH) forming residues; other site 246196007782 trimer interface [polypeptide binding]; other site 246196007783 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 246196007784 NAD binding site [chemical binding]; other site 246196007785 catalytic residues [active] 246196007786 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 246196007787 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196007788 catalytic Zn binding site [ion binding]; other site 246196007789 structural Zn binding site [ion binding]; other site 246196007790 tetramer interface [polypeptide binding]; other site 246196007791 acyl-CoA synthetase; Validated; Region: PRK08316 246196007792 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196007793 acyl-activating enzyme (AAE) consensus motif; other site 246196007794 putative AMP binding site [chemical binding]; other site 246196007795 putative active site [active] 246196007796 putative CoA binding site [chemical binding]; other site 246196007797 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196007798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196007799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007800 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196007801 NAD(P) binding site [chemical binding]; other site 246196007802 active site 246196007803 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 246196007804 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 246196007805 active site 246196007806 FMN binding site [chemical binding]; other site 246196007807 substrate binding site [chemical binding]; other site 246196007808 putative catalytic residue [active] 246196007809 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196007810 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196007811 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196007812 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196007813 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196007814 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 246196007815 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 246196007816 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 246196007817 active site 246196007818 Fe binding site [ion binding]; other site 246196007819 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196007820 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196007821 active site 246196007822 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 246196007823 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 246196007824 FAD binding pocket [chemical binding]; other site 246196007825 FAD binding motif [chemical binding]; other site 246196007826 phosphate binding motif [ion binding]; other site 246196007827 beta-alpha-beta structure motif; other site 246196007828 NAD(p) ribose binding residues [chemical binding]; other site 246196007829 NAD binding pocket [chemical binding]; other site 246196007830 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 246196007831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196007832 catalytic loop [active] 246196007833 iron binding site [ion binding]; other site 246196007834 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196007835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196007836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007837 short chain dehydrogenase; Provisional; Region: PRK07454 246196007838 NAD(P) binding site [chemical binding]; other site 246196007839 active site 246196007840 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196007841 ACT domain; Region: ACT_7; pfam13840 246196007842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196007843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196007844 short chain dehydrogenase; Validated; Region: PRK08264 246196007845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007846 NAD(P) binding site [chemical binding]; other site 246196007847 active site 246196007848 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196007849 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 246196007850 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196007851 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 246196007852 active site 246196007853 catalytic triad [active] 246196007854 dimer interface [polypeptide binding]; other site 246196007855 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196007856 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196007857 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 246196007858 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 246196007859 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 246196007860 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 246196007861 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246196007862 substrate binding site [chemical binding]; other site 246196007863 ATP binding site [chemical binding]; other site 246196007864 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 246196007865 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 246196007866 metal binding site [ion binding]; metal-binding site 246196007867 substrate binding pocket [chemical binding]; other site 246196007868 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196007869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196007870 DNA-binding site [nucleotide binding]; DNA binding site 246196007871 FCD domain; Region: FCD; pfam07729 246196007872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007873 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196007874 putative substrate translocation pore; other site 246196007875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196007876 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196007877 putative substrate translocation pore; other site 246196007878 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 246196007879 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 246196007880 putative NAD(P) binding site [chemical binding]; other site 246196007881 catalytic Zn binding site [ion binding]; other site 246196007882 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196007883 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 246196007884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196007885 dimer interface [polypeptide binding]; other site 246196007886 phosphorylation site [posttranslational modification] 246196007887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196007888 ATP binding site [chemical binding]; other site 246196007889 Mg2+ binding site [ion binding]; other site 246196007890 G-X-G motif; other site 246196007891 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196007892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196007893 active site 246196007894 phosphorylation site [posttranslational modification] 246196007895 intermolecular recognition site; other site 246196007896 dimerization interface [polypeptide binding]; other site 246196007897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196007898 DNA binding site [nucleotide binding] 246196007899 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196007900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007901 NAD(P) binding site [chemical binding]; other site 246196007902 active site 246196007903 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 246196007904 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 246196007905 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 246196007906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196007907 active site 246196007908 catalytic tetrad [active] 246196007909 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 246196007910 dimer interface [polypeptide binding]; other site 246196007911 FMN binding site [chemical binding]; other site 246196007912 NADPH bind site [chemical binding]; other site 246196007913 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196007914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196007915 NAD(P) binding site [chemical binding]; other site 246196007916 active site 246196007917 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 246196007918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007919 dimer interface [polypeptide binding]; other site 246196007920 conserved gate region; other site 246196007921 putative PBP binding loops; other site 246196007922 ABC-ATPase subunit interface; other site 246196007923 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 246196007924 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 246196007925 Walker A/P-loop; other site 246196007926 ATP binding site [chemical binding]; other site 246196007927 Q-loop/lid; other site 246196007928 ABC transporter signature motif; other site 246196007929 Walker B; other site 246196007930 D-loop; other site 246196007931 H-loop/switch region; other site 246196007932 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 246196007933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196007934 dimer interface [polypeptide binding]; other site 246196007935 conserved gate region; other site 246196007936 putative PBP binding loops; other site 246196007937 ABC-ATPase subunit interface; other site 246196007938 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196007939 CoenzymeA binding site [chemical binding]; other site 246196007940 subunit interaction site [polypeptide binding]; other site 246196007941 PHB binding site; other site 246196007942 TIGR02611 family protein; Region: TIGR02611 246196007943 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 246196007944 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 246196007945 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 246196007946 active site 246196007947 dimer interface [polypeptide binding]; other site 246196007948 motif 1; other site 246196007949 motif 2; other site 246196007950 motif 3; other site 246196007951 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 246196007952 anticodon binding site; other site 246196007953 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 246196007954 nucleotide binding site/active site [active] 246196007955 HIT family signature motif; other site 246196007956 catalytic residue [active] 246196007957 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 246196007958 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 246196007959 putative acyl-acceptor binding pocket; other site 246196007960 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196007961 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196007962 LemA family; Region: LemA; cl00742 246196007963 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246196007964 nudix motif; other site 246196007965 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 246196007966 active site 246196007967 multimer interface [polypeptide binding]; other site 246196007968 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 246196007969 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196007970 active site 246196007971 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196007972 catalytic triad [active] 246196007973 dimer interface [polypeptide binding]; other site 246196007974 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 246196007975 predicted active site [active] 246196007976 catalytic triad [active] 246196007977 hypothetical protein; Validated; Region: PRK00110 246196007978 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196007979 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 246196007980 NAD(P) binding site [chemical binding]; other site 246196007981 putative active site [active] 246196007982 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 246196007983 putative metal binding site [ion binding]; other site 246196007984 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 246196007985 active site 246196007986 putative DNA-binding cleft [nucleotide binding]; other site 246196007987 dimer interface [polypeptide binding]; other site 246196007988 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 246196007989 RuvA N terminal domain; Region: RuvA_N; pfam01330 246196007990 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 246196007991 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 246196007992 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 246196007993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196007994 Walker A motif; other site 246196007995 ATP binding site [chemical binding]; other site 246196007996 Walker B motif; other site 246196007997 arginine finger; other site 246196007998 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 246196007999 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 246196008000 Putative cyclase; Region: Cyclase; pfam04199 246196008001 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196008002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196008003 substrate binding site [chemical binding]; other site 246196008004 oxyanion hole (OAH) forming residues; other site 246196008005 trimer interface [polypeptide binding]; other site 246196008006 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196008007 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196008008 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196008009 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196008010 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 246196008011 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196008012 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196008013 catalytic loop [active] 246196008014 iron binding site [ion binding]; other site 246196008015 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196008016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008017 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196008018 putative substrate translocation pore; other site 246196008019 EthD domain; Region: EthD; cl17553 246196008020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196008021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196008022 DNA binding site [nucleotide binding] 246196008023 domain linker motif; other site 246196008024 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196008025 ligand binding site [chemical binding]; other site 246196008026 dimerization interface [polypeptide binding]; other site 246196008027 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196008028 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246196008029 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196008030 acyl-activating enzyme (AAE) consensus motif; other site 246196008031 AMP binding site [chemical binding]; other site 246196008032 active site 246196008033 CoA binding site [chemical binding]; other site 246196008034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196008035 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196008036 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246196008037 putative NAD(P) binding site [chemical binding]; other site 246196008038 active site 246196008039 putative substrate binding site [chemical binding]; other site 246196008040 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196008041 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196008042 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196008043 inhibitor-cofactor binding pocket; inhibition site 246196008044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008045 catalytic residue [active] 246196008046 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 246196008047 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 246196008048 protein-export membrane protein SecD; Region: secD; TIGR01129 246196008049 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 246196008050 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 246196008051 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 246196008052 Protein export membrane protein; Region: SecD_SecF; pfam02355 246196008053 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 246196008054 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196008055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196008056 active site 246196008057 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 246196008058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196008059 Zn2+ binding site [ion binding]; other site 246196008060 Mg2+ binding site [ion binding]; other site 246196008061 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 246196008062 synthetase active site [active] 246196008063 NTP binding site [chemical binding]; other site 246196008064 metal binding site [ion binding]; metal-binding site 246196008065 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 246196008066 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 246196008067 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 246196008068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008069 putative substrate translocation pore; other site 246196008070 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 246196008071 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 246196008072 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 246196008073 active site 246196008074 FMN binding site [chemical binding]; other site 246196008075 substrate binding site [chemical binding]; other site 246196008076 putative catalytic residue [active] 246196008077 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 246196008078 active site 246196008079 catalytic site [active] 246196008080 Zn binding site [ion binding]; other site 246196008081 tetramer interface [polypeptide binding]; other site 246196008082 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196008083 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196008084 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196008085 Na binding site [ion binding]; other site 246196008086 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 246196008087 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246196008088 active site 246196008089 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246196008090 active site 246196008091 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 246196008092 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 246196008093 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 246196008094 dimer interface [polypeptide binding]; other site 246196008095 motif 1; other site 246196008096 active site 246196008097 motif 2; other site 246196008098 motif 3; other site 246196008099 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 246196008100 anticodon binding site; other site 246196008101 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 246196008102 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246196008103 Walker A/P-loop; other site 246196008104 ATP binding site [chemical binding]; other site 246196008105 Q-loop/lid; other site 246196008106 ABC transporter signature motif; other site 246196008107 Walker B; other site 246196008108 D-loop; other site 246196008109 H-loop/switch region; other site 246196008110 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 246196008111 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246196008112 Walker A/P-loop; other site 246196008113 ATP binding site [chemical binding]; other site 246196008114 Q-loop/lid; other site 246196008115 ABC transporter signature motif; other site 246196008116 Walker B; other site 246196008117 D-loop; other site 246196008118 H-loop/switch region; other site 246196008119 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246196008120 TM-ABC transporter signature motif; other site 246196008121 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246196008122 TM-ABC transporter signature motif; other site 246196008123 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 246196008124 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 246196008125 putative ligand binding site [chemical binding]; other site 246196008126 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196008127 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196008128 catalytic site [active] 246196008129 fumarate hydratase; Provisional; Region: PRK15389 246196008130 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 246196008131 Fumarase C-terminus; Region: Fumerase_C; pfam05683 246196008132 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196008133 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 246196008134 putative active site [active] 246196008135 catalytic triad [active] 246196008136 putative dimer interface [polypeptide binding]; other site 246196008137 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196008138 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196008139 DNA binding site [nucleotide binding] 246196008140 domain linker motif; other site 246196008141 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 246196008142 putative dimerization interface [polypeptide binding]; other site 246196008143 putative ligand binding site [chemical binding]; other site 246196008144 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 246196008145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196008146 FeS/SAM binding site; other site 246196008147 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 246196008148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008149 putative substrate translocation pore; other site 246196008150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196008151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196008152 active site 246196008153 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196008154 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 246196008155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196008156 active site 246196008157 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196008158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196008159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008160 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196008161 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 246196008162 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196008163 active site 246196008164 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196008165 catalytic triad [active] 246196008166 dimer interface [polypeptide binding]; other site 246196008167 DinB superfamily; Region: DinB_2; pfam12867 246196008168 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 246196008169 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 246196008170 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 246196008171 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 246196008172 substrate binding pocket [chemical binding]; other site 246196008173 catalytic triad [active] 246196008174 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 246196008175 putative hydrophobic ligand binding site [chemical binding]; other site 246196008176 protein interface [polypeptide binding]; other site 246196008177 gate; other site 246196008178 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 246196008179 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 246196008180 dimer interface [polypeptide binding]; other site 246196008181 anticodon binding site; other site 246196008182 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 246196008183 homodimer interface [polypeptide binding]; other site 246196008184 motif 1; other site 246196008185 active site 246196008186 motif 2; other site 246196008187 GAD domain; Region: GAD; pfam02938 246196008188 motif 3; other site 246196008189 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196008190 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 246196008191 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196008192 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196008193 6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191 246196008194 putative active site [active] 246196008195 metal binding site [ion binding]; metal-binding site 246196008196 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 246196008197 tetramerization interface [polypeptide binding]; other site 246196008198 NAD(P) binding site [chemical binding]; other site 246196008199 catalytic residues [active] 246196008200 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 246196008201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 246196008202 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246196008203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196008204 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196008205 NAD(P) binding site [chemical binding]; other site 246196008206 active site 246196008207 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196008208 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196008209 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196008210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196008211 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 246196008212 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196008213 dimer interface [polypeptide binding]; other site 246196008214 active site 246196008215 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196008216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196008217 putative DNA binding site [nucleotide binding]; other site 246196008218 YjbR; Region: YjbR; cl15265 246196008219 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196008220 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246196008221 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 246196008222 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246196008223 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 246196008224 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448 246196008225 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl19824 246196008226 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246196008227 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 246196008228 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246196008229 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 246196008230 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 246196008231 recombination factor protein RarA; Reviewed; Region: PRK13342 246196008232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196008233 Walker A motif; other site 246196008234 ATP binding site [chemical binding]; other site 246196008235 Walker B motif; other site 246196008236 arginine finger; other site 246196008237 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 246196008238 Predicted membrane protein [Function unknown]; Region: COG2261 246196008239 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 246196008240 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 246196008241 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 246196008242 motif 1; other site 246196008243 active site 246196008244 motif 2; other site 246196008245 motif 3; other site 246196008246 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 246196008247 DHHA1 domain; Region: DHHA1; pfam02272 246196008248 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 246196008249 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 246196008250 dimerization interface [polypeptide binding]; other site 246196008251 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 246196008252 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 246196008253 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 246196008254 shikimate binding site; other site 246196008255 NAD(P) binding site [chemical binding]; other site 246196008256 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 246196008257 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 246196008258 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 246196008259 Tetramer interface [polypeptide binding]; other site 246196008260 active site 246196008261 FMN-binding site [chemical binding]; other site 246196008262 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 246196008263 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 246196008264 ADP binding site [chemical binding]; other site 246196008265 magnesium binding site [ion binding]; other site 246196008266 putative shikimate binding site; other site 246196008267 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 246196008268 active site 246196008269 dimer interface [polypeptide binding]; other site 246196008270 metal binding site [ion binding]; metal-binding site 246196008271 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196008272 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196008273 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 246196008274 active site 246196008275 elongation factor P; Validated; Region: PRK00529 246196008276 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 246196008277 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 246196008278 RNA binding site [nucleotide binding]; other site 246196008279 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 246196008280 RNA binding site [nucleotide binding]; other site 246196008281 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 246196008282 putative RNA binding site [nucleotide binding]; other site 246196008283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196008284 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246196008285 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196008286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196008287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196008288 S-adenosylmethionine binding site [chemical binding]; other site 246196008289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196008290 active site 246196008291 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 246196008292 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 246196008293 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 246196008294 dihydroorotase; Validated; Region: pyrC; PRK09357 246196008295 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196008296 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 246196008297 active site 246196008298 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 246196008299 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 246196008300 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 246196008301 catalytic site [active] 246196008302 subunit interface [polypeptide binding]; other site 246196008303 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 246196008304 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196008305 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196008306 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 246196008307 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196008308 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196008309 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 246196008310 IMP binding site; other site 246196008311 dimer interface [polypeptide binding]; other site 246196008312 interdomain contacts; other site 246196008313 partial ornithine binding site; other site 246196008314 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 246196008315 active site 246196008316 dimer interface [polypeptide binding]; other site 246196008317 Guanylate kinase; Region: Guanylate_kin; pfam00625 246196008318 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 246196008319 catalytic site [active] 246196008320 G-X2-G-X-G-K; other site 246196008321 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 246196008322 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 246196008323 Flavoprotein; Region: Flavoprotein; cl19190 246196008324 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 246196008325 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 246196008326 S-adenosylmethionine synthetase; Validated; Region: PRK05250 246196008327 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 246196008328 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 246196008329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196008330 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 246196008331 Walker A/P-loop; other site 246196008332 ATP binding site [chemical binding]; other site 246196008333 Q-loop/lid; other site 246196008334 ABC transporter signature motif; other site 246196008335 Walker B; other site 246196008336 D-loop; other site 246196008337 H-loop/switch region; other site 246196008338 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 246196008339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008340 dimer interface [polypeptide binding]; other site 246196008341 conserved gate region; other site 246196008342 putative PBP binding loops; other site 246196008343 ABC-ATPase subunit interface; other site 246196008344 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 246196008345 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196008346 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196008347 Predicted membrane protein [Function unknown]; Region: COG3714 246196008348 primosome assembly protein PriA; Provisional; Region: PRK14873 246196008349 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 246196008350 LemA family; Region: LemA; cl00742 246196008351 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 246196008352 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 246196008353 putative active site [active] 246196008354 substrate binding site [chemical binding]; other site 246196008355 putative cosubstrate binding site; other site 246196008356 catalytic site [active] 246196008357 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 246196008358 substrate binding site [chemical binding]; other site 246196008359 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 246196008360 putative RNA binding site [nucleotide binding]; other site 246196008361 16S rRNA methyltransferase B; Provisional; Region: PRK14902 246196008362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196008363 S-adenosylmethionine binding site [chemical binding]; other site 246196008364 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 246196008365 substrate binding site [chemical binding]; other site 246196008366 hexamer interface [polypeptide binding]; other site 246196008367 metal binding site [ion binding]; metal-binding site 246196008368 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 246196008369 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 246196008370 catalytic motif [active] 246196008371 Zn binding site [ion binding]; other site 246196008372 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 246196008373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196008374 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 246196008375 putative substrate translocation pore; other site 246196008376 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 246196008377 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 246196008378 Lumazine binding domain; Region: Lum_binding; pfam00677 246196008379 Lumazine binding domain; Region: Lum_binding; pfam00677 246196008380 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 246196008381 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 246196008382 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 246196008383 dimerization interface [polypeptide binding]; other site 246196008384 active site 246196008385 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 246196008386 homopentamer interface [polypeptide binding]; other site 246196008387 active site 246196008388 Bacterial PH domain; Region: bPH_6; pfam10756 246196008389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196008390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196008391 Coenzyme A binding pocket [chemical binding]; other site 246196008392 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 246196008393 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 246196008394 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 246196008395 GIY-YIG motif/motif A; other site 246196008396 active site 246196008397 catalytic site [active] 246196008398 putative DNA binding site [nucleotide binding]; other site 246196008399 metal binding site [ion binding]; metal-binding site 246196008400 UvrB/uvrC motif; Region: UVR; pfam02151 246196008401 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 246196008402 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 246196008403 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 246196008404 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 246196008405 phosphate binding site [ion binding]; other site 246196008406 putative substrate binding pocket [chemical binding]; other site 246196008407 dimer interface [polypeptide binding]; other site 246196008408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 246196008409 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 246196008410 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 246196008411 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 246196008412 SOUL heme-binding protein; Region: SOUL; pfam04832 246196008413 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 246196008414 putative hydrophobic ligand binding site [chemical binding]; other site 246196008415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196008416 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 246196008417 NAD(P) binding site [chemical binding]; other site 246196008418 active site 246196008419 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 246196008420 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 246196008421 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 246196008422 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 246196008423 substrate binding site [chemical binding]; other site 246196008424 hinge regions; other site 246196008425 ADP binding site [chemical binding]; other site 246196008426 catalytic site [active] 246196008427 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 246196008428 substrate binding site [chemical binding]; other site 246196008429 dimer interface [polypeptide binding]; other site 246196008430 catalytic triad [active] 246196008431 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 246196008432 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 246196008433 intersubunit interface [polypeptide binding]; other site 246196008434 active site 246196008435 catalytic residue [active] 246196008436 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196008437 TM-ABC transporter signature motif; other site 246196008438 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196008439 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196008440 Walker A/P-loop; other site 246196008441 ATP binding site [chemical binding]; other site 246196008442 Q-loop/lid; other site 246196008443 ABC transporter signature motif; other site 246196008444 Walker B; other site 246196008445 D-loop; other site 246196008446 H-loop/switch region; other site 246196008447 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196008448 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196008449 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196008450 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 246196008451 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 246196008452 N- and C-terminal domain interface [polypeptide binding]; other site 246196008453 active site 246196008454 MgATP binding site [chemical binding]; other site 246196008455 catalytic site [active] 246196008456 metal binding site [ion binding]; metal-binding site 246196008457 putative carbohydrate binding site [chemical binding]; other site 246196008458 putative homodimer interface [polypeptide binding]; other site 246196008459 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 246196008460 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 246196008461 putative NAD(P) binding site [chemical binding]; other site 246196008462 catalytic Zn binding site [ion binding]; other site 246196008463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196008464 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 246196008465 putative ligand binding site [chemical binding]; other site 246196008466 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 246196008467 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 246196008468 putative active site [active] 246196008469 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 246196008470 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 246196008471 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 246196008472 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 246196008473 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 246196008474 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 246196008475 putative active site [active] 246196008476 catalytic residue [active] 246196008477 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 246196008478 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 246196008479 TPP-binding site [chemical binding]; other site 246196008480 dimer interface [polypeptide binding]; other site 246196008481 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246196008482 PYR/PP interface [polypeptide binding]; other site 246196008483 dimer interface [polypeptide binding]; other site 246196008484 TPP binding site [chemical binding]; other site 246196008485 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196008486 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 246196008487 putative active site [active] 246196008488 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 246196008489 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 246196008490 NADP binding site [chemical binding]; other site 246196008491 dimer interface [polypeptide binding]; other site 246196008492 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 246196008493 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196008494 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196008495 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246196008496 Walker A/P-loop; other site 246196008497 ATP binding site [chemical binding]; other site 246196008498 Q-loop/lid; other site 246196008499 ABC transporter signature motif; other site 246196008500 Walker B; other site 246196008501 D-loop; other site 246196008502 H-loop/switch region; other site 246196008503 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196008504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008505 dimer interface [polypeptide binding]; other site 246196008506 conserved gate region; other site 246196008507 putative PBP binding loops; other site 246196008508 ABC-ATPase subunit interface; other site 246196008509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008510 dimer interface [polypeptide binding]; other site 246196008511 conserved gate region; other site 246196008512 putative PBP binding loops; other site 246196008513 ABC-ATPase subunit interface; other site 246196008514 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196008515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196008516 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196008517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196008518 NAD(P) binding site [chemical binding]; other site 246196008519 active site 246196008520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196008521 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 246196008522 nucleotide binding site [chemical binding]; other site 246196008523 BtpA family; Region: BtpA; cl00440 246196008524 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 246196008525 active site 246196008526 dimerization interface [polypeptide binding]; other site 246196008527 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 246196008528 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 246196008529 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 246196008530 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 246196008531 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246196008532 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196008533 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196008534 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196008535 Walker A/P-loop; other site 246196008536 ATP binding site [chemical binding]; other site 246196008537 Q-loop/lid; other site 246196008538 ABC transporter signature motif; other site 246196008539 Walker B; other site 246196008540 D-loop; other site 246196008541 H-loop/switch region; other site 246196008542 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 246196008543 Predicted transcriptional regulator [Transcription]; Region: COG2345 246196008544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196008545 putative DNA binding site [nucleotide binding]; other site 246196008546 putative Zn2+ binding site [ion binding]; other site 246196008547 FeS assembly protein SufB; Region: sufB; TIGR01980 246196008548 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 246196008549 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 246196008550 FeS assembly protein SufD; Region: sufD; TIGR01981 246196008551 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 246196008552 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 246196008553 Walker A/P-loop; other site 246196008554 ATP binding site [chemical binding]; other site 246196008555 Q-loop/lid; other site 246196008556 ABC transporter signature motif; other site 246196008557 Walker B; other site 246196008558 D-loop; other site 246196008559 H-loop/switch region; other site 246196008560 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 246196008561 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196008562 catalytic residue [active] 246196008563 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 246196008564 trimerization site [polypeptide binding]; other site 246196008565 active site 246196008566 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 246196008567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196008568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008569 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246196008570 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 246196008571 acyl-activating enzyme (AAE) consensus motif; other site 246196008572 putative AMP binding site [chemical binding]; other site 246196008573 putative active site [active] 246196008574 putative CoA binding site [chemical binding]; other site 246196008575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196008576 salt bridge; other site 246196008577 non-specific DNA binding site [nucleotide binding]; other site 246196008578 sequence-specific DNA binding site [nucleotide binding]; other site 246196008579 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196008580 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 246196008581 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246196008582 phosphate binding site [ion binding]; other site 246196008583 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246196008584 catalytic residues [active] 246196008585 enoyl-CoA hydratase; Provisional; Region: PRK05864 246196008586 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196008587 substrate binding site [chemical binding]; other site 246196008588 oxyanion hole (OAH) forming residues; other site 246196008589 trimer interface [polypeptide binding]; other site 246196008590 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246196008591 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196008592 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246196008593 ABC transporter; Region: ABC_tran_2; pfam12848 246196008594 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196008595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196008596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008597 aconitate hydratase; Validated; Region: PRK09277 246196008598 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246196008599 substrate binding site [chemical binding]; other site 246196008600 ligand binding site [chemical binding]; other site 246196008601 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 246196008602 substrate binding site [chemical binding]; other site 246196008603 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196008604 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196008605 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196008606 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196008607 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196008608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196008609 Walker A motif; other site 246196008610 ATP binding site [chemical binding]; other site 246196008611 Walker B motif; other site 246196008612 arginine finger; other site 246196008613 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246196008614 Protein of unknown function DUF58; Region: DUF58; pfam01882 246196008615 hypothetical protein; Provisional; Region: PRK13685 246196008616 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 246196008617 von Willebrand factor type A domain; Region: VWA_2; pfam13519 246196008618 metal ion-dependent adhesion site (MIDAS); other site 246196008619 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 246196008620 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246196008621 NAD(P) binding site [chemical binding]; other site 246196008622 homotetramer interface [polypeptide binding]; other site 246196008623 homodimer interface [polypeptide binding]; other site 246196008624 active site 246196008625 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 246196008626 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 246196008627 NAD binding site [chemical binding]; other site 246196008628 homotetramer interface [polypeptide binding]; other site 246196008629 homodimer interface [polypeptide binding]; other site 246196008630 substrate binding site [chemical binding]; other site 246196008631 active site 246196008632 ferrochelatase; Reviewed; Region: hemH; PRK00035 246196008633 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 246196008634 C-terminal domain interface [polypeptide binding]; other site 246196008635 active site 246196008636 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 246196008637 active site 246196008638 N-terminal domain interface [polypeptide binding]; other site 246196008639 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 246196008640 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246196008641 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 246196008642 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 246196008643 DoxX-like family; Region: DoxX_2; pfam13564 246196008644 Uncharacterized conserved protein [Function unknown]; Region: COG0398 246196008645 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 246196008646 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 246196008647 heterodimer interface [polypeptide binding]; other site 246196008648 substrate interaction site [chemical binding]; other site 246196008649 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246196008650 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 246196008651 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 246196008652 active site 246196008653 substrate binding site [chemical binding]; other site 246196008654 coenzyme B12 binding site [chemical binding]; other site 246196008655 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 246196008656 B12 binding site [chemical binding]; other site 246196008657 cobalt ligand [ion binding]; other site 246196008658 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 246196008659 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 246196008660 Walker A; other site 246196008661 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 246196008662 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196008663 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196008664 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196008665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196008666 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196008667 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 246196008668 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246196008669 active site 246196008670 HIGH motif; other site 246196008671 nucleotide binding site [chemical binding]; other site 246196008672 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 246196008673 active site 246196008674 KMSKS motif; other site 246196008675 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 246196008676 tRNA binding surface [nucleotide binding]; other site 246196008677 anticodon binding site; other site 246196008678 Flagellar P-ring protein; Region: FlgI; cl19280 246196008679 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196008680 RNA binding surface [nucleotide binding]; other site 246196008681 DNA polymerase IV; Provisional; Region: PRK03348 246196008682 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246196008683 active site 246196008684 DNA binding site [nucleotide binding] 246196008685 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 246196008686 active site 246196008687 homodimer interface [polypeptide binding]; other site 246196008688 homotetramer interface [polypeptide binding]; other site 246196008689 lipoprotein signal peptidase; Provisional; Region: PRK14764 246196008690 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 246196008691 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 246196008692 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246196008693 active site 246196008694 Predicted permeases [General function prediction only]; Region: RarD; COG2962 246196008695 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 246196008696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196008697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008698 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 246196008699 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 246196008700 active site 246196008701 PHP Thumb interface [polypeptide binding]; other site 246196008702 metal binding site [ion binding]; metal-binding site 246196008703 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 246196008704 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 246196008705 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 246196008706 generic binding surface II; other site 246196008707 generic binding surface I; other site 246196008708 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 246196008709 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246196008710 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 246196008711 DNA binding residues [nucleotide binding] 246196008712 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 246196008713 hydrophobic ligand binding site; other site 246196008714 threonine dehydratase; Validated; Region: PRK08639 246196008715 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 246196008716 tetramer interface [polypeptide binding]; other site 246196008717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008718 catalytic residue [active] 246196008719 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 246196008720 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 246196008721 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 246196008722 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 246196008723 catalytic site [active] 246196008724 active site 246196008725 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 246196008726 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 246196008727 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 246196008728 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 246196008729 active site 246196008730 catalytic site [active] 246196008731 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196008732 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196008733 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196008734 inhibitor-cofactor binding pocket; inhibition site 246196008735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008736 catalytic residue [active] 246196008737 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 246196008738 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 246196008739 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196008740 catalytic residue [active] 246196008741 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 246196008742 AAA domain; Region: AAA_26; pfam13500 246196008743 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 246196008744 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196008745 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196008746 tetracycline repressor protein TetR; Provisional; Region: PRK13756 246196008747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196008748 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196008749 biotin synthase; Validated; Region: PRK06256 246196008750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196008751 FeS/SAM binding site; other site 246196008752 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 246196008753 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 246196008754 Secretory lipase; Region: LIP; pfam03583 246196008755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196008756 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 246196008757 nudix motif; other site 246196008758 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 246196008759 quinolinate synthetase; Provisional; Region: PRK09375 246196008760 L-aspartate oxidase; Provisional; Region: PRK07804 246196008761 L-aspartate oxidase; Provisional; Region: PRK06175 246196008762 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196008763 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 246196008764 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 246196008765 dimerization interface [polypeptide binding]; other site 246196008766 active site 246196008767 LysE type translocator; Region: LysE; cl00565 246196008768 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196008769 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 246196008770 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 246196008771 NAD binding site [chemical binding]; other site 246196008772 dimerization interface [polypeptide binding]; other site 246196008773 product binding site; other site 246196008774 substrate binding site [chemical binding]; other site 246196008775 zinc binding site [ion binding]; other site 246196008776 catalytic residues [active] 246196008777 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 246196008778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196008779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008780 homodimer interface [polypeptide binding]; other site 246196008781 catalytic residue [active] 246196008782 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 246196008783 putative active site pocket [active] 246196008784 4-fold oligomerization interface [polypeptide binding]; other site 246196008785 metal binding residues [ion binding]; metal-binding site 246196008786 3-fold/trimer interface [polypeptide binding]; other site 246196008787 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 246196008788 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 246196008789 putative active site [active] 246196008790 oxyanion strand; other site 246196008791 catalytic triad [active] 246196008792 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 246196008793 catalytic residues [active] 246196008794 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 246196008795 active site 246196008796 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 246196008797 substrate binding site [chemical binding]; other site 246196008798 glutamase interaction surface [polypeptide binding]; other site 246196008799 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 246196008800 Methyltransferase domain; Region: Methyltransf_26; pfam13659 246196008801 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196008802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196008803 Walker A/P-loop; other site 246196008804 ATP binding site [chemical binding]; other site 246196008805 Q-loop/lid; other site 246196008806 ABC transporter signature motif; other site 246196008807 Walker B; other site 246196008808 D-loop; other site 246196008809 H-loop/switch region; other site 246196008810 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246196008811 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 246196008812 catalytic triad [active] 246196008813 anthranilate synthase component I; Provisional; Region: PRK13571 246196008814 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 246196008815 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246196008816 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 246196008817 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 246196008818 active site 246196008819 ribulose/triose binding site [chemical binding]; other site 246196008820 phosphate binding site [ion binding]; other site 246196008821 substrate (anthranilate) binding pocket [chemical binding]; other site 246196008822 product (indole) binding pocket [chemical binding]; other site 246196008823 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 246196008824 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 246196008825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196008826 catalytic residue [active] 246196008827 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 246196008828 substrate binding site [chemical binding]; other site 246196008829 active site 246196008830 catalytic residues [active] 246196008831 heterodimer interface [polypeptide binding]; other site 246196008832 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 246196008833 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 246196008834 TM2 domain; Region: TM2; pfam05154 246196008835 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 246196008836 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 246196008837 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 246196008838 active site 246196008839 dimer interface [polypeptide binding]; other site 246196008840 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 246196008841 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246196008842 active site 246196008843 FMN binding site [chemical binding]; other site 246196008844 substrate binding site [chemical binding]; other site 246196008845 3Fe-4S cluster binding site [ion binding]; other site 246196008846 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 246196008847 domain interface; other site 246196008848 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 246196008849 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 246196008850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196008851 pyruvate kinase; Provisional; Region: PRK06247 246196008852 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 246196008853 domain interfaces; other site 246196008854 active site 246196008855 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 246196008856 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196008857 active site 246196008858 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196008859 catalytic triad [active] 246196008860 dimer interface [polypeptide binding]; other site 246196008861 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 246196008862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196008863 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 246196008864 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 246196008865 Walker A/P-loop; other site 246196008866 ATP binding site [chemical binding]; other site 246196008867 Q-loop/lid; other site 246196008868 ABC transporter signature motif; other site 246196008869 Walker B; other site 246196008870 D-loop; other site 246196008871 H-loop/switch region; other site 246196008872 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 246196008873 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 246196008874 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 246196008875 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 246196008876 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196008877 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196008878 substrate binding pocket [chemical binding]; other site 246196008879 membrane-bound complex binding site; other site 246196008880 hinge residues; other site 246196008881 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196008882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008883 dimer interface [polypeptide binding]; other site 246196008884 conserved gate region; other site 246196008885 putative PBP binding loops; other site 246196008886 ABC-ATPase subunit interface; other site 246196008887 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196008888 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196008889 Walker A/P-loop; other site 246196008890 ATP binding site [chemical binding]; other site 246196008891 Q-loop/lid; other site 246196008892 ABC transporter signature motif; other site 246196008893 Walker B; other site 246196008894 D-loop; other site 246196008895 H-loop/switch region; other site 246196008896 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 246196008897 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 246196008898 active site residue [active] 246196008899 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 246196008900 active site residue [active] 246196008901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196008902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196008903 ATP binding site [chemical binding]; other site 246196008904 G-X-G motif; other site 246196008905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196008906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196008907 active site 246196008908 phosphorylation site [posttranslational modification] 246196008909 intermolecular recognition site; other site 246196008910 dimerization interface [polypeptide binding]; other site 246196008911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196008912 DNA binding residues [nucleotide binding] 246196008913 dimerization interface [polypeptide binding]; other site 246196008914 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 246196008915 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 246196008916 Ferritin-like domain; Region: Ferritin; pfam00210 246196008917 dimerization interface [polypeptide binding]; other site 246196008918 DPS ferroxidase diiron center [ion binding]; other site 246196008919 ion pore; other site 246196008920 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 246196008921 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 246196008922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196008923 active site 246196008924 phosphorylation site [posttranslational modification] 246196008925 intermolecular recognition site; other site 246196008926 dimerization interface [polypeptide binding]; other site 246196008927 ANTAR domain; Region: ANTAR; pfam03861 246196008928 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 246196008929 dimerization interface [polypeptide binding]; other site 246196008930 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 246196008931 ligand binding site [chemical binding]; other site 246196008932 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246196008933 TM-ABC transporter signature motif; other site 246196008934 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246196008935 TM-ABC transporter signature motif; other site 246196008936 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196008937 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246196008938 Walker A/P-loop; other site 246196008939 ATP binding site [chemical binding]; other site 246196008940 Q-loop/lid; other site 246196008941 ABC transporter signature motif; other site 246196008942 Walker B; other site 246196008943 D-loop; other site 246196008944 H-loop/switch region; other site 246196008945 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246196008946 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246196008947 Walker A/P-loop; other site 246196008948 ATP binding site [chemical binding]; other site 246196008949 Q-loop/lid; other site 246196008950 ABC transporter signature motif; other site 246196008951 Walker B; other site 246196008952 D-loop; other site 246196008953 H-loop/switch region; other site 246196008954 hypothetical protein; Provisional; Region: PRK02237 246196008955 RDD family; Region: RDD; pfam06271 246196008956 Predicted membrane protein [Function unknown]; Region: COG2259 246196008957 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196008958 D-xylulose kinase; Region: XylB; TIGR01312 246196008959 nucleotide binding site [chemical binding]; other site 246196008960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196008961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196008962 active site 246196008963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196008964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196008965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196008966 dimerization interface [polypeptide binding]; other site 246196008967 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196008968 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 246196008969 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 246196008970 N- and C-terminal domain interface [polypeptide binding]; other site 246196008971 putative active site [active] 246196008972 putative xylulose binding site [chemical binding]; other site 246196008973 MgATP binding site [chemical binding]; other site 246196008974 putative homodimer interface [polypeptide binding]; other site 246196008975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196008976 short chain dehydrogenase; Provisional; Region: PRK07060 246196008977 NAD(P) binding site [chemical binding]; other site 246196008978 active site 246196008979 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196008980 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 246196008981 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196008982 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196008983 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196008984 NAD(P) binding site [chemical binding]; other site 246196008985 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196008986 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196008987 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196008988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008989 dimer interface [polypeptide binding]; other site 246196008990 conserved gate region; other site 246196008991 putative PBP binding loops; other site 246196008992 ABC-ATPase subunit interface; other site 246196008993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196008994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196008995 dimer interface [polypeptide binding]; other site 246196008996 conserved gate region; other site 246196008997 putative PBP binding loops; other site 246196008998 ABC-ATPase subunit interface; other site 246196008999 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 246196009000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196009001 Walker A/P-loop; other site 246196009002 ATP binding site [chemical binding]; other site 246196009003 Q-loop/lid; other site 246196009004 ABC transporter signature motif; other site 246196009005 Walker B; other site 246196009006 D-loop; other site 246196009007 H-loop/switch region; other site 246196009008 TOBE domain; Region: TOBE_2; pfam08402 246196009009 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 246196009010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196009011 Walker A/P-loop; other site 246196009012 ATP binding site [chemical binding]; other site 246196009013 Q-loop/lid; other site 246196009014 ABC transporter signature motif; other site 246196009015 Walker B; other site 246196009016 D-loop; other site 246196009017 H-loop/switch region; other site 246196009018 dihydroxyacetone kinase; Provisional; Region: PRK14479 246196009019 Dak1 domain; Region: Dak1; cl10557 246196009020 DAK2 domain; Region: Dak2; pfam02734 246196009021 ribose 5-phosphate isomerase; Region: RPI_actino; TIGR02133 246196009022 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 246196009023 metal binding site [ion binding]; metal-binding site 246196009024 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 246196009025 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196009026 DNA binding residues [nucleotide binding] 246196009027 drug binding residues [chemical binding]; other site 246196009028 dimer interface [polypeptide binding]; other site 246196009029 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 246196009030 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246196009031 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246196009032 DNA binding residues [nucleotide binding] 246196009033 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 246196009034 EamA-like transporter family; Region: EamA; pfam00892 246196009035 Src Homology 3 domain superfamily; Region: SH3; cl17036 246196009036 peptide ligand binding site [polypeptide binding]; other site 246196009037 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196009038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009039 dimer interface [polypeptide binding]; other site 246196009040 conserved gate region; other site 246196009041 putative PBP binding loops; other site 246196009042 ABC-ATPase subunit interface; other site 246196009043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009044 dimer interface [polypeptide binding]; other site 246196009045 conserved gate region; other site 246196009046 putative PBP binding loops; other site 246196009047 ABC-ATPase subunit interface; other site 246196009048 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 246196009049 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196009050 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 246196009051 Walker A/P-loop; other site 246196009052 ATP binding site [chemical binding]; other site 246196009053 Q-loop/lid; other site 246196009054 ABC transporter signature motif; other site 246196009055 Walker B; other site 246196009056 D-loop; other site 246196009057 H-loop/switch region; other site 246196009058 TOBE domain; Region: TOBE_2; pfam08402 246196009059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009061 putative substrate translocation pore; other site 246196009062 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196009063 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196009064 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 246196009065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196009066 S-adenosylmethionine binding site [chemical binding]; other site 246196009067 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 246196009068 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196009069 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196009070 nucleophilic elbow; other site 246196009071 catalytic triad; other site 246196009072 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196009073 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196009074 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196009075 AAA ATPase domain; Region: AAA_16; pfam13191 246196009076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196009077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196009078 DNA binding residues [nucleotide binding] 246196009079 dimerization interface [polypeptide binding]; other site 246196009080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196009081 salt bridge; other site 246196009082 non-specific DNA binding site [nucleotide binding]; other site 246196009083 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196009084 sequence-specific DNA binding site [nucleotide binding]; other site 246196009085 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 246196009086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196009087 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246196009088 DNA binding residues [nucleotide binding] 246196009089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196009090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196009091 DNA binding site [nucleotide binding] 246196009092 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196009093 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196009094 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196009095 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196009096 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196009097 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196009098 short chain dehydrogenase; Provisional; Region: PRK06180 246196009099 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196009100 NADP binding site [chemical binding]; other site 246196009101 active site 246196009102 steroid binding site; other site 246196009103 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196009104 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246196009105 NAD(P) binding site [chemical binding]; other site 246196009106 catalytic residues [active] 246196009107 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246196009108 EamA-like transporter family; Region: EamA; pfam00892 246196009109 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 246196009110 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196009111 NAD(P) binding site [chemical binding]; other site 246196009112 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196009113 Ligand Binding Site [chemical binding]; other site 246196009114 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 246196009115 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196009116 catalytic residue [active] 246196009117 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 246196009118 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 246196009119 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 246196009120 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 246196009121 Fe binding site [ion binding]; other site 246196009122 MarR family; Region: MarR_2; pfam12802 246196009123 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196009124 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196009125 nucleotide binding site [chemical binding]; other site 246196009126 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196009127 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196009128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009129 putative substrate translocation pore; other site 246196009130 poly-U binding splicing factor, half-pint family; Region: half-pint; TIGR01645 246196009131 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196009132 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196009133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009136 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196009137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196009138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009140 CoA-transferase family III; Region: CoA_transf_3; cl19215 246196009141 CoA-transferase family III; Region: CoA_transf_3; cl19215 246196009142 AAA domain; Region: AAA_22; pfam13401 246196009143 Bacterial TniB protein; Region: TniB; pfam05621 246196009144 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 246196009145 CsbD-like; Region: CsbD; pfam05532 246196009146 tetracycline repressor protein TetR; Provisional; Region: PRK13756 246196009147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009148 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246196009149 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196009150 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196009151 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196009152 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196009153 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196009154 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 246196009155 active site 246196009156 FMN binding site [chemical binding]; other site 246196009157 substrate binding site [chemical binding]; other site 246196009158 homotetramer interface [polypeptide binding]; other site 246196009159 catalytic residue [active] 246196009160 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196009161 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196009162 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196009163 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196009164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196009165 DNA-binding site [nucleotide binding]; DNA binding site 246196009166 FCD domain; Region: FCD; pfam07729 246196009167 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 246196009168 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 246196009169 putative active site [active] 246196009170 catalytic triad [active] 246196009171 putative dimer interface [polypeptide binding]; other site 246196009172 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 246196009173 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 246196009174 DctM-like transporters; Region: DctM; pfam06808 246196009175 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 246196009176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009178 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196009179 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 246196009180 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 246196009181 NADP binding site [chemical binding]; other site 246196009182 active site 246196009183 regulatory binding site [polypeptide binding]; other site 246196009184 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196009185 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 246196009186 YaeQ protein; Region: YaeQ; pfam07152 246196009187 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 246196009188 Putative oxalocrotonate tautomerase enzyme; Region: Tautomerase_3; pfam14832 246196009189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009191 enoyl-CoA hydratase; Provisional; Region: PRK06563 246196009192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196009193 substrate binding site [chemical binding]; other site 246196009194 oxyanion hole (OAH) forming residues; other site 246196009195 trimer interface [polypeptide binding]; other site 246196009196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009198 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 246196009199 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246196009200 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196009201 conserved cys residue [active] 246196009202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196009203 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 246196009204 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 246196009205 conserved cys residue [active] 246196009206 short chain dehydrogenase; Provisional; Region: PRK06500 246196009207 classical (c) SDRs; Region: SDR_c; cd05233 246196009208 NAD(P) binding site [chemical binding]; other site 246196009209 active site 246196009210 benzoate transport; Region: 2A0115; TIGR00895 246196009211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009212 putative substrate translocation pore; other site 246196009213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009214 dimerization interface [polypeptide binding]; other site 246196009215 putative DNA binding site [nucleotide binding]; other site 246196009216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009218 putative substrate translocation pore; other site 246196009219 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 246196009220 choline dehydrogenase; Validated; Region: PRK02106 246196009221 lycopene cyclase; Region: lycopene_cycl; TIGR01789 246196009222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196009223 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196009224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196009225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009226 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196009227 NAD(P) binding site [chemical binding]; other site 246196009228 active site 246196009229 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196009230 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196009231 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 246196009232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009233 dimerization interface [polypeptide binding]; other site 246196009234 putative DNA binding site [nucleotide binding]; other site 246196009235 putative Zn2+ binding site [ion binding]; other site 246196009236 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 246196009237 NAD(P) binding site [chemical binding]; other site 246196009238 active site lysine 246196009239 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196009240 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196009241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009242 putative substrate translocation pore; other site 246196009243 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196009244 NAD binding site [chemical binding]; other site 246196009245 catalytic residues [active] 246196009246 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 246196009247 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196009248 NAD binding site [chemical binding]; other site 246196009249 catalytic Zn binding site [ion binding]; other site 246196009250 substrate binding site [chemical binding]; other site 246196009251 structural Zn binding site [ion binding]; other site 246196009252 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 246196009253 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196009254 PYR/PP interface [polypeptide binding]; other site 246196009255 dimer interface [polypeptide binding]; other site 246196009256 TPP binding site [chemical binding]; other site 246196009257 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196009258 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 246196009259 TPP-binding site [chemical binding]; other site 246196009260 enoyl-CoA hydratase; Provisional; Region: PRK09245 246196009261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196009262 substrate binding site [chemical binding]; other site 246196009263 oxyanion hole (OAH) forming residues; other site 246196009264 trimer interface [polypeptide binding]; other site 246196009265 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196009266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196009267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196009268 active site 246196009269 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196009270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196009271 Cupin domain; Region: Cupin_2; cl17218 246196009272 short chain dehydrogenase; Provisional; Region: PRK06125 246196009273 classical (c) SDRs; Region: SDR_c; cd05233 246196009274 NAD(P) binding site [chemical binding]; other site 246196009275 active site 246196009276 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196009277 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196009278 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196009279 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 246196009280 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 246196009281 metal binding site [ion binding]; metal-binding site 246196009282 dimer interface [polypeptide binding]; other site 246196009283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009284 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196009285 putative substrate translocation pore; other site 246196009286 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196009287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196009288 DNA-binding site [nucleotide binding]; DNA binding site 246196009289 FCD domain; Region: FCD; pfam07729 246196009290 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196009291 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 246196009292 putative active site [active] 246196009293 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196009294 Na binding site [ion binding]; other site 246196009295 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 246196009296 multimer interface [polypeptide binding]; other site 246196009297 active site 246196009298 catalytic triad [active] 246196009299 dimer interface [polypeptide binding]; other site 246196009300 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196009301 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196009302 active site 246196009303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009305 putative substrate translocation pore; other site 246196009306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009307 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 246196009308 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196009309 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246196009310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196009311 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196009312 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196009313 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 246196009314 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196009315 putative NAD(P) binding site [chemical binding]; other site 246196009316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009318 Transcriptional regulator, TetR, C-terminal; Region: TetR_C_9; pfam14514 246196009319 MOSC domain; Region: MOSC; pfam03473 246196009320 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 246196009321 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 246196009322 putative active site [active] 246196009323 putative catalytic site [active] 246196009324 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246196009325 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196009326 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196009327 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246196009328 EamA-like transporter family; Region: EamA; cl17759 246196009329 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 246196009330 putative hydrophobic ligand binding site [chemical binding]; other site 246196009331 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 246196009332 hydrophobic ligand binding site; other site 246196009333 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 246196009334 dinuclear metal binding motif [ion binding]; other site 246196009335 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 246196009336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009337 NAD(P) binding site [chemical binding]; other site 246196009338 active site 246196009339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009340 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196009341 putative substrate translocation pore; other site 246196009342 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 246196009343 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 246196009344 NAD binding site [chemical binding]; other site 246196009345 ligand binding site [chemical binding]; other site 246196009346 catalytic site [active] 246196009347 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196009348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009349 putative DNA binding site [nucleotide binding]; other site 246196009350 putative Zn2+ binding site [ion binding]; other site 246196009351 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196009352 Leucine carboxyl methyltransferase; Region: LCM; cl01306 246196009353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009355 short chain dehydrogenase; Provisional; Region: PRK06180 246196009356 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196009357 NADP binding site [chemical binding]; other site 246196009358 active site 246196009359 steroid binding site; other site 246196009360 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196009361 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196009362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196009363 S-adenosylmethionine binding site [chemical binding]; other site 246196009364 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196009365 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196009366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196009367 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196009368 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246196009369 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 246196009370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 246196009371 AAA domain; Region: AAA_33; pfam13671 246196009372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196009373 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246196009374 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196009375 Putative esterase; Region: Esterase; pfam00756 246196009376 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196009377 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 246196009378 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 246196009379 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 246196009380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196009381 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196009382 substrate binding pocket [chemical binding]; other site 246196009383 membrane-bound complex binding site; other site 246196009384 hinge residues; other site 246196009385 choline dehydrogenase; Validated; Region: PRK02106 246196009386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196009387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196009388 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196009389 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196009390 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196009391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196009392 active site 246196009393 phosphorylation site [posttranslational modification] 246196009394 intermolecular recognition site; other site 246196009395 dimerization interface [polypeptide binding]; other site 246196009396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196009397 DNA binding residues [nucleotide binding] 246196009398 dimerization interface [polypeptide binding]; other site 246196009399 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196009400 Histidine kinase; Region: HisKA_3; pfam07730 246196009401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196009402 ATP binding site [chemical binding]; other site 246196009403 Mg2+ binding site [ion binding]; other site 246196009404 G-X-G motif; other site 246196009405 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 246196009406 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 246196009407 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 246196009408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196009409 motif II; other site 246196009410 short chain dehydrogenase; Provisional; Region: PRK08263 246196009411 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246196009412 NADP binding site [chemical binding]; other site 246196009413 active site 246196009414 steroid binding site; other site 246196009415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009417 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196009418 RNA binding surface [nucleotide binding]; other site 246196009419 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246196009420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196009421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196009422 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196009423 active site 2 [active] 246196009424 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196009425 active site 1 [active] 246196009426 Uncharacterized conserved protein [Function unknown]; Region: COG2966 246196009427 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 246196009428 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 246196009429 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246196009430 metal binding site 2 [ion binding]; metal-binding site 246196009431 putative DNA binding helix; other site 246196009432 metal binding site 1 [ion binding]; metal-binding site 246196009433 dimer interface [polypeptide binding]; other site 246196009434 structural Zn2+ binding site [ion binding]; other site 246196009435 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 246196009436 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 246196009437 dimer interface [polypeptide binding]; other site 246196009438 active site 246196009439 heme binding site [chemical binding]; other site 246196009440 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 246196009441 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196009442 FMN binding site [chemical binding]; other site 246196009443 dimer interface [polypeptide binding]; other site 246196009444 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196009445 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196009446 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196009447 NAD(P) binding site [chemical binding]; other site 246196009448 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 246196009449 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196009450 acyl-activating enzyme (AAE) consensus motif; other site 246196009451 active site 246196009452 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196009453 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196009454 acyl-activating enzyme (AAE) consensus motif; other site 246196009455 AMP binding site [chemical binding]; other site 246196009456 active site 246196009457 CoA binding site [chemical binding]; other site 246196009458 YacP-like NYN domain; Region: NYN_YacP; cl01491 246196009459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009461 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 246196009462 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196009463 putative NAD(P) binding site [chemical binding]; other site 246196009464 hypothetical protein; Validated; Region: PRK07198 246196009465 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 246196009466 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 246196009467 dimerization interface [polypeptide binding]; other site 246196009468 active site 246196009469 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 246196009470 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196009471 active site 246196009472 CAAX protease self-immunity; Region: Abi; pfam02517 246196009473 Peptidase family M48; Region: Peptidase_M48; pfam01435 246196009474 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196009475 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196009476 Putative transcription activator [Transcription]; Region: TenA; COG0819 246196009477 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 246196009478 dimer interface [polypeptide binding]; other site 246196009479 catalytic triad [active] 246196009480 peroxidatic and resolving cysteines [active] 246196009481 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 246196009482 O-succinylbenzoate synthase; Provisional; Region: PRK02901 246196009483 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 246196009484 metal binding site [ion binding]; metal-binding site 246196009485 substrate binding pocket [chemical binding]; other site 246196009486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 246196009487 MOSC domain; Region: MOSC; pfam03473 246196009488 3-alpha domain; Region: 3-alpha; pfam03475 246196009489 Cupin domain; Region: Cupin_2; pfam07883 246196009490 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 246196009491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196009492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196009493 DNA binding residues [nucleotide binding] 246196009494 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 246196009495 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 246196009496 tetramer interface [polypeptide binding]; other site 246196009497 heme binding pocket [chemical binding]; other site 246196009498 NADPH binding site [chemical binding]; other site 246196009499 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 246196009500 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196009501 Zn2+ binding site [ion binding]; other site 246196009502 Mg2+ binding site [ion binding]; other site 246196009503 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246196009504 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196009505 conserved cys residue [active] 246196009506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196009507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196009508 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 246196009509 active site 246196009510 catalytic triad [active] 246196009511 oxyanion hole [active] 246196009512 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196009513 Sulfatase; Region: Sulfatase; cl19157 246196009514 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196009515 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 246196009516 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196009517 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196009518 MMPL family; Region: MMPL; pfam03176 246196009519 MMPL family; Region: MMPL; pfam03176 246196009520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009521 dimerization interface [polypeptide binding]; other site 246196009522 putative DNA binding site [nucleotide binding]; other site 246196009523 putative Zn2+ binding site [ion binding]; other site 246196009524 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 246196009525 putative hydrophobic ligand binding site [chemical binding]; other site 246196009526 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196009527 NlpC/P60 family; Region: NLPC_P60; cl17555 246196009528 hypothetical protein; Validated; Region: PRK02101 246196009529 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196009530 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 246196009531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196009532 catalytic residue [active] 246196009533 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 246196009534 putative active site [active] 246196009535 catalytic residue [active] 246196009536 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196009537 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196009538 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196009539 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196009540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196009541 Squalene epoxidase; Region: SE; cl17314 246196009542 Winged helix-turn helix; Region: HTH_29; pfam13551 246196009543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196009544 putative DNA binding site [nucleotide binding]; other site 246196009545 dimerization interface [polypeptide binding]; other site 246196009546 putative Zn2+ binding site [ion binding]; other site 246196009547 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196009548 competence damage-inducible protein A; Provisional; Region: PRK00549 246196009549 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 246196009550 putative MPT binding site; other site 246196009551 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 246196009552 hypothetical protein; Provisional; Region: PRK01346 246196009553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196009554 Coenzyme A binding pocket [chemical binding]; other site 246196009555 Sterol carrier protein domain; Region: SCP2_2; pfam13530 246196009556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196009558 NAD(P) binding site [chemical binding]; other site 246196009559 active site 246196009560 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 246196009561 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 246196009562 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196009563 active site 246196009564 Nitronate monooxygenase; Region: NMO; pfam03060 246196009565 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196009566 FMN binding site [chemical binding]; other site 246196009567 substrate binding site [chemical binding]; other site 246196009568 putative catalytic residue [active] 246196009569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009570 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 246196009571 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246196009572 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246196009573 molybdopterin cofactor binding site; other site 246196009574 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 246196009575 molybdopterin cofactor binding site; other site 246196009576 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196009577 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196009578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196009579 non-specific DNA binding site [nucleotide binding]; other site 246196009580 salt bridge; other site 246196009581 sequence-specific DNA binding site [nucleotide binding]; other site 246196009582 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196009583 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246196009584 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196009585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196009586 DNA-binding site [nucleotide binding]; DNA binding site 246196009587 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 246196009588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196009589 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 246196009590 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196009591 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 246196009592 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 246196009593 POT family; Region: PTR2; cl17359 246196009594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009595 putative substrate translocation pore; other site 246196009596 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 246196009597 tetramer interface [polypeptide binding]; other site 246196009598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196009599 catalytic residue [active] 246196009600 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246196009601 active site 246196009602 Agmatinase-like family; Region: Agmatinase-like; cd09990 246196009603 active site 246196009604 oligomer interface [polypeptide binding]; other site 246196009605 Mn binding site [ion binding]; other site 246196009606 benzoate transport; Region: 2A0115; TIGR00895 246196009607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009608 putative substrate translocation pore; other site 246196009609 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246196009610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246196009611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196009612 S-adenosylmethionine binding site [chemical binding]; other site 246196009613 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 246196009614 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 246196009615 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 246196009616 catalytic residues [active] 246196009617 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 246196009618 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 246196009619 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 246196009620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196009621 membrane-bound complex binding site; other site 246196009622 hinge residues; other site 246196009623 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196009624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009625 dimer interface [polypeptide binding]; other site 246196009626 conserved gate region; other site 246196009627 putative PBP binding loops; other site 246196009628 ABC-ATPase subunit interface; other site 246196009629 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196009630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009631 dimer interface [polypeptide binding]; other site 246196009632 conserved gate region; other site 246196009633 putative PBP binding loops; other site 246196009634 ABC-ATPase subunit interface; other site 246196009635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196009636 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196009637 Walker A/P-loop; other site 246196009638 ATP binding site [chemical binding]; other site 246196009639 Q-loop/lid; other site 246196009640 ABC transporter signature motif; other site 246196009641 Walker B; other site 246196009642 D-loop; other site 246196009643 H-loop/switch region; other site 246196009644 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196009645 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196009646 phenylhydantoinase; Validated; Region: PRK08323 246196009647 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 246196009648 tetramer interface [polypeptide binding]; other site 246196009649 active site 246196009650 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196009651 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 246196009652 active site 246196009653 catalytic triad [active] 246196009654 dimer interface [polypeptide binding]; other site 246196009655 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 246196009656 Na binding site [ion binding]; other site 246196009657 putative substrate binding site [chemical binding]; other site 246196009658 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196009659 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246196009660 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196009661 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196009662 short chain dehydrogenase; Provisional; Region: PRK08303 246196009663 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 246196009664 NAD(P) binding site [chemical binding]; other site 246196009665 active site 246196009666 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196009667 active site 246196009668 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196009669 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196009670 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196009671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009673 putative substrate translocation pore; other site 246196009674 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 246196009675 Ferritin-like domain; Region: Ferritin; pfam00210 246196009676 heme binding site [chemical binding]; other site 246196009677 ferroxidase pore; other site 246196009678 ferroxidase diiron center [ion binding]; other site 246196009679 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 246196009680 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196009681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196009682 substrate binding site [chemical binding]; other site 246196009683 oxyanion hole (OAH) forming residues; other site 246196009684 trimer interface [polypeptide binding]; other site 246196009685 EthD domain; Region: EthD; cl17553 246196009686 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 246196009687 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246196009688 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196009689 CoenzymeA binding site [chemical binding]; other site 246196009690 subunit interaction site [polypeptide binding]; other site 246196009691 PHB binding site; other site 246196009692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009693 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 246196009694 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 246196009695 TPR repeat; Region: TPR_11; pfam13414 246196009696 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246196009697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196009698 binding surface 246196009699 TPR motif; other site 246196009700 TPR repeat; Region: TPR_11; pfam13414 246196009701 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246196009702 nucleoside/Zn binding site; other site 246196009703 dimer interface [polypeptide binding]; other site 246196009704 catalytic motif [active] 246196009705 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 246196009706 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 246196009707 active site 246196009708 catalytic site [active] 246196009709 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 246196009710 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196009711 dimerization interface [polypeptide binding]; other site 246196009712 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196009713 cyclase homology domain; Region: CHD; cd07302 246196009714 nucleotidyl binding site; other site 246196009715 metal binding site [ion binding]; metal-binding site 246196009716 dimer interface [polypeptide binding]; other site 246196009717 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246196009718 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246196009719 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196009720 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196009721 ligand binding site [chemical binding]; other site 246196009722 flexible hinge region; other site 246196009723 Predicted esterase [General function prediction only]; Region: COG0627 246196009724 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196009725 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196009726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009727 NAD(P) binding site [chemical binding]; other site 246196009728 active site 246196009729 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 246196009730 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 246196009731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196009732 Walker A motif; other site 246196009733 ATP binding site [chemical binding]; other site 246196009734 Walker B motif; other site 246196009735 arginine finger; other site 246196009736 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246196009737 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196009738 Transport protein; Region: actII; TIGR00833 246196009739 MMPL family; Region: MMPL; pfam03176 246196009740 MMPL family; Region: MMPL; pfam03176 246196009741 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196009742 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196009743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009744 putative substrate translocation pore; other site 246196009745 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 246196009746 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196009747 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 246196009748 Protein of unknown function DUF72; Region: DUF72; pfam01904 246196009749 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 246196009750 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196009751 NAD(P) binding site [chemical binding]; other site 246196009752 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196009753 Reductase C-terminal; Region: Reductase_C; pfam14759 246196009754 AAA ATPase domain; Region: AAA_16; pfam13191 246196009755 Domain of unknown function DUF87; Region: DUF87; cl19135 246196009756 AAA-like domain; Region: AAA_10; pfam12846 246196009757 Zonular occludens toxin (Zot); Region: Zot; cl17485 246196009758 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196009759 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 246196009760 putative ligand binding site [chemical binding]; other site 246196009761 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196009762 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 246196009763 putative ligand binding site [chemical binding]; other site 246196009764 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196009765 TM-ABC transporter signature motif; other site 246196009766 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196009767 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196009768 Walker A/P-loop; other site 246196009769 ATP binding site [chemical binding]; other site 246196009770 Q-loop/lid; other site 246196009771 ABC transporter signature motif; other site 246196009772 Walker B; other site 246196009773 D-loop; other site 246196009774 H-loop/switch region; other site 246196009775 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196009776 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196009777 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196009778 NAD(P) binding site [chemical binding]; other site 246196009779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196009780 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196009781 NAD(P) binding site [chemical binding]; other site 246196009782 active site 246196009783 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196009784 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 246196009785 inhibitor binding site; inhibition site 246196009786 catalytic Zn binding site [ion binding]; other site 246196009787 structural Zn binding site [ion binding]; other site 246196009788 NADP binding site [chemical binding]; other site 246196009789 tetramer interface [polypeptide binding]; other site 246196009790 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196009791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246196009792 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196009793 short chain dehydrogenase; Provisional; Region: PRK06841 246196009794 classical (c) SDRs; Region: SDR_c; cd05233 246196009795 NAD(P) binding site [chemical binding]; other site 246196009796 active site 246196009797 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 246196009798 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196009799 active site 246196009800 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196009801 putative phosphoketolase; Provisional; Region: PRK05261 246196009802 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 246196009803 TPP-binding site; other site 246196009804 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 246196009805 XFP C-terminal domain; Region: XFP_C; pfam09363 246196009806 CAAX protease self-immunity; Region: Abi; pfam02517 246196009807 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 246196009808 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196009809 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196009810 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 246196009811 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 246196009812 putative NAD(P) binding site [chemical binding]; other site 246196009813 putative substrate binding site [chemical binding]; other site 246196009814 catalytic Zn binding site [ion binding]; other site 246196009815 structural Zn binding site [ion binding]; other site 246196009816 Predicted membrane protein [Function unknown]; Region: COG2261 246196009817 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 246196009818 classical (c) SDRs; Region: SDR_c; cd05233 246196009819 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196009820 NAD(P) binding site [chemical binding]; other site 246196009821 active site 246196009822 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196009823 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246196009824 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196009825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196009826 UreD urease accessory protein; Region: UreD; cl00530 246196009827 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196009828 UreF; Region: UreF; cl19817 246196009829 urease subunit alpha; Reviewed; Region: ureC; PRK13206 246196009830 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 246196009831 subunit interactions [polypeptide binding]; other site 246196009832 active site 246196009833 flap region; other site 246196009834 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 246196009835 gamma-beta subunit interface [polypeptide binding]; other site 246196009836 alpha-beta subunit interface [polypeptide binding]; other site 246196009837 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 246196009838 alpha-gamma subunit interface [polypeptide binding]; other site 246196009839 beta-gamma subunit interface [polypeptide binding]; other site 246196009840 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196009841 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196009842 CoenzymeA binding site [chemical binding]; other site 246196009843 subunit interaction site [polypeptide binding]; other site 246196009844 PHB binding site; other site 246196009845 Predicted transcriptional regulator [Transcription]; Region: COG3682 246196009846 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 246196009847 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196009848 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 246196009849 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 246196009850 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 246196009851 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 246196009852 active site 246196009853 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 246196009854 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196009855 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 246196009856 Walker A/P-loop; other site 246196009857 ATP binding site [chemical binding]; other site 246196009858 Q-loop/lid; other site 246196009859 ABC transporter signature motif; other site 246196009860 Walker B; other site 246196009861 D-loop; other site 246196009862 H-loop/switch region; other site 246196009863 TOBE domain; Region: TOBE_2; pfam08402 246196009864 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 246196009865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009866 dimer interface [polypeptide binding]; other site 246196009867 conserved gate region; other site 246196009868 putative PBP binding loops; other site 246196009869 ABC-ATPase subunit interface; other site 246196009870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196009871 dimer interface [polypeptide binding]; other site 246196009872 conserved gate region; other site 246196009873 putative PBP binding loops; other site 246196009874 ABC-ATPase subunit interface; other site 246196009875 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246196009876 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246196009877 Domain of unknown function DUF21; Region: DUF21; pfam01595 246196009878 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246196009879 Transporter associated domain; Region: CorC_HlyC; pfam03471 246196009880 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246196009881 Domain of unknown function DUF21; Region: DUF21; pfam01595 246196009882 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246196009883 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 246196009884 active site 246196009885 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246196009886 metal ion-dependent adhesion site (MIDAS); other site 246196009887 glycine dehydrogenase; Provisional; Region: PRK05367 246196009888 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 246196009889 tetramer interface [polypeptide binding]; other site 246196009890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196009891 catalytic residue [active] 246196009892 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 246196009893 tetramer interface [polypeptide binding]; other site 246196009894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196009895 catalytic residue [active] 246196009896 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 246196009897 DNA binding residues [nucleotide binding] 246196009898 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196009899 putative dimer interface [polypeptide binding]; other site 246196009900 Bifunctional nuclease; Region: DNase-RNase; pfam02577 246196009901 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196009902 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 246196009903 DNA binding residues [nucleotide binding] 246196009904 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246196009905 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246196009906 phosphopeptide binding site; other site 246196009907 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 246196009908 lipoyl attachment site [posttranslational modification]; other site 246196009909 Bacterial protein of unknown function (DUF881); Region: DUF881; cl19849 246196009910 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 246196009911 Bacterial protein of unknown function (DUF881); Region: DUF881; cl19849 246196009912 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 246196009913 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 246196009914 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 246196009915 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 246196009916 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 246196009917 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 246196009918 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 246196009919 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 246196009920 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 246196009921 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 246196009922 hypothetical protein; Validated; Region: PRK07121 246196009923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196009924 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 246196009925 substrate binding site [chemical binding]; other site 246196009926 dimer interface [polypeptide binding]; other site 246196009927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196009928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196009929 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196009930 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 246196009931 dimerization interface [polypeptide binding]; other site 246196009932 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 246196009933 mannose binding site [chemical binding]; other site 246196009934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246196009935 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 246196009936 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196009937 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 246196009938 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 246196009939 TrkA-C domain; Region: TrkA_C; pfam02080 246196009940 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246196009941 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246196009942 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 246196009943 substrate binding pocket [chemical binding]; other site 246196009944 catalytic triad [active] 246196009945 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196009946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196009947 active site 246196009948 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 246196009949 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 246196009950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196009951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196009952 putative substrate translocation pore; other site 246196009953 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 246196009954 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 246196009955 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 246196009956 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196009957 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196009958 FMN-binding pocket [chemical binding]; other site 246196009959 flavin binding motif; other site 246196009960 phosphate binding motif [ion binding]; other site 246196009961 beta-alpha-beta structure motif; other site 246196009962 NAD binding pocket [chemical binding]; other site 246196009963 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196009964 catalytic loop [active] 246196009965 iron binding site [ion binding]; other site 246196009966 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196009967 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196009968 active site 246196009969 ATP binding site [chemical binding]; other site 246196009970 substrate binding site [chemical binding]; other site 246196009971 activation loop (A-loop); other site 246196009972 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246196009973 nudix motif; other site 246196009974 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 246196009975 active site 246196009976 catalytic triad [active] 246196009977 oxyanion hole [active] 246196009978 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196009979 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196009980 acyl-CoA synthetase; Validated; Region: PRK07798 246196009981 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196009982 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196009983 acyl-activating enzyme (AAE) consensus motif; other site 246196009984 acyl-activating enzyme (AAE) consensus motif; other site 246196009985 AMP binding site [chemical binding]; other site 246196009986 active site 246196009987 CoA binding site [chemical binding]; other site 246196009988 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 246196009989 Na binding site [ion binding]; other site 246196009990 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 246196009991 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 246196009992 nucleotide binding site/active site [active] 246196009993 HIT family signature motif; other site 246196009994 catalytic residue [active] 246196009995 galactokinase; Provisional; Region: PRK00555 246196009996 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 246196009997 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 246196009998 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 246196009999 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196010000 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196010001 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196010002 acyl-activating enzyme (AAE) consensus motif; other site 246196010003 putative AMP binding site [chemical binding]; other site 246196010004 putative active site [active] 246196010005 putative CoA binding site [chemical binding]; other site 246196010006 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196010007 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196010008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196010009 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196010010 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 246196010011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010012 short chain dehydrogenase; Provisional; Region: PRK06057 246196010013 NAD(P) binding site [chemical binding]; other site 246196010014 active site 246196010015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010016 D-galactonate transporter; Region: 2A0114; TIGR00893 246196010017 putative substrate translocation pore; other site 246196010018 isocitrate lyase; Region: PLN02892 246196010019 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196010020 tetramer interface [polypeptide binding]; other site 246196010021 active site 246196010022 Mg2+/Mn2+ binding site [ion binding]; other site 246196010023 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 246196010024 putative heme binding pocket [chemical binding]; other site 246196010025 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 246196010026 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246196010027 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196010028 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246196010029 acyl-activating enzyme (AAE) consensus motif; other site 246196010030 AMP binding site [chemical binding]; other site 246196010031 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196010032 Condensation domain; Region: Condensation; cl19241 246196010033 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196010034 Condensation domain; Region: Condensation; cl19241 246196010035 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196010036 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196010037 acyl-activating enzyme (AAE) consensus motif; other site 246196010038 AMP binding site [chemical binding]; other site 246196010039 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196010040 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196010041 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246196010042 putative NAD(P) binding site [chemical binding]; other site 246196010043 active site 246196010044 putative substrate binding site [chemical binding]; other site 246196010045 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 246196010046 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 246196010047 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246196010048 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 246196010049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196010050 FeS/SAM binding site; other site 246196010051 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246196010052 coenzyme PQQ biosynthesis protein PqqD; Region: PQQ_PqqD; TIGR03859 246196010053 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 246196010054 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 246196010055 coenzyme PQQ precursor peptide PqqA; Region: PQQ_syn_pqqA; TIGR02107 246196010056 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 246196010057 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246196010058 Trp docking motif [polypeptide binding]; other site 246196010059 active site 246196010060 Actinobacterial PQQ system protein; Region: PQQ_MSMEG_3727; TIGR04339 246196010061 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 246196010062 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 246196010063 heme binding site [chemical binding]; other site 246196010064 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 246196010065 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 246196010066 LytTr DNA-binding domain; Region: LytTR; smart00850 246196010067 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 246196010068 active site 246196010069 dimer interface [polypeptide binding]; other site 246196010070 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 246196010071 Predicted permeases [General function prediction only]; Region: COG0730 246196010072 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196010073 GTP-binding protein Der; Reviewed; Region: PRK03003 246196010074 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 246196010075 G1 box; other site 246196010076 GTP/Mg2+ binding site [chemical binding]; other site 246196010077 Switch I region; other site 246196010078 G2 box; other site 246196010079 Switch II region; other site 246196010080 G3 box; other site 246196010081 G4 box; other site 246196010082 G5 box; other site 246196010083 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 246196010084 G1 box; other site 246196010085 GTP/Mg2+ binding site [chemical binding]; other site 246196010086 Switch I region; other site 246196010087 G2 box; other site 246196010088 G3 box; other site 246196010089 Switch II region; other site 246196010090 G4 box; other site 246196010091 G5 box; other site 246196010092 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 246196010093 cytidylate kinase; Provisional; Region: cmk; PRK00023 246196010094 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 246196010095 CMP-binding site; other site 246196010096 The sites determining sugar specificity; other site 246196010097 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 246196010098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196010099 RNA binding surface [nucleotide binding]; other site 246196010100 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 246196010101 active site 246196010102 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 246196010103 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 246196010104 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246196010105 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196010106 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196010107 P-loop; other site 246196010108 Magnesium ion binding site [ion binding]; other site 246196010109 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 246196010110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196010111 active site 246196010112 DNA binding site [nucleotide binding] 246196010113 Int/Topo IB signature motif; other site 246196010114 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 246196010115 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 246196010116 dimer interface [polypeptide binding]; other site 246196010117 ADP-ribose binding site [chemical binding]; other site 246196010118 active site 246196010119 nudix motif; other site 246196010120 metal binding site [ion binding]; metal-binding site 246196010121 CTP synthetase; Validated; Region: pyrG; PRK05380 246196010122 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 246196010123 Catalytic site [active] 246196010124 active site 246196010125 UTP binding site [chemical binding]; other site 246196010126 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 246196010127 active site 246196010128 putative oxyanion hole; other site 246196010129 catalytic triad [active] 246196010130 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 246196010131 Thiamine pyrophosphokinase; Region: TPK; cd07995 246196010132 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 246196010133 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 246196010134 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 246196010135 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196010136 RNA binding surface [nucleotide binding]; other site 246196010137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196010138 S-adenosylmethionine binding site [chemical binding]; other site 246196010139 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 246196010140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196010141 active site 246196010142 motif I; other site 246196010143 motif II; other site 246196010144 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 246196010145 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246196010146 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 246196010147 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 246196010148 active site 246196010149 HIGH motif; other site 246196010150 dimer interface [polypeptide binding]; other site 246196010151 KMSKS motif; other site 246196010152 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246196010153 RNA binding surface [nucleotide binding]; other site 246196010154 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 246196010155 active site 246196010156 DNA binding site [nucleotide binding] 246196010157 Homeodomain-like domain; Region: HTH_23; pfam13384 246196010158 Clp amino terminal domain; Region: Clp_N; pfam02861 246196010159 Clp amino terminal domain; Region: Clp_N; pfam02861 246196010160 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 246196010161 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196010162 Walker A/P-loop; other site 246196010163 ATP binding site [chemical binding]; other site 246196010164 Q-loop/lid; other site 246196010165 ABC transporter signature motif; other site 246196010166 Walker B; other site 246196010167 D-loop; other site 246196010168 H-loop/switch region; other site 246196010169 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246196010170 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196010171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010173 Uncharacterized conserved protein [Function unknown]; Region: COG2835 246196010174 acyl-CoA synthetase; Validated; Region: PRK07868 246196010175 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 246196010176 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196010177 acyl-activating enzyme (AAE) consensus motif; other site 246196010178 AMP binding site [chemical binding]; other site 246196010179 active site 246196010180 CoA binding site [chemical binding]; other site 246196010181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196010182 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246196010183 ABC transporter; Region: ABC_tran_2; pfam12848 246196010184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196010185 argininosuccinate lyase; Provisional; Region: PRK00855 246196010186 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 246196010187 active sites [active] 246196010188 tetramer interface [polypeptide binding]; other site 246196010189 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 246196010190 ANP binding site [chemical binding]; other site 246196010191 Substrate Binding Site II [chemical binding]; other site 246196010192 Substrate Binding Site I [chemical binding]; other site 246196010193 arginine repressor; Provisional; Region: PRK03341 246196010194 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 246196010195 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 246196010196 ornithine carbamoyltransferase; Provisional; Region: PRK00779 246196010197 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 246196010198 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 246196010199 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196010200 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196010201 inhibitor-cofactor binding pocket; inhibition site 246196010202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196010203 catalytic residue [active] 246196010204 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 246196010205 feedback inhibition sensing region; other site 246196010206 homohexameric interface [polypeptide binding]; other site 246196010207 nucleotide binding site [chemical binding]; other site 246196010208 N-acetyl-L-glutamate binding site [chemical binding]; other site 246196010209 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 246196010210 heterotetramer interface [polypeptide binding]; other site 246196010211 active site pocket [active] 246196010212 cleavage site 246196010213 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 246196010214 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246196010215 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 246196010216 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 246196010217 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 246196010218 putative tRNA-binding site [nucleotide binding]; other site 246196010219 B3/4 domain; Region: B3_4; pfam03483 246196010220 tRNA synthetase B5 domain; Region: B5; smart00874 246196010221 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 246196010222 dimer interface [polypeptide binding]; other site 246196010223 motif 1; other site 246196010224 motif 3; other site 246196010225 motif 2; other site 246196010226 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 246196010227 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 246196010228 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 246196010229 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 246196010230 dimer interface [polypeptide binding]; other site 246196010231 motif 1; other site 246196010232 active site 246196010233 motif 2; other site 246196010234 motif 3; other site 246196010235 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196010236 cyclase homology domain; Region: CHD; cd07302 246196010237 nucleotidyl binding site; other site 246196010238 metal binding site [ion binding]; metal-binding site 246196010239 dimer interface [polypeptide binding]; other site 246196010240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 246196010241 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196010242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196010243 active site 246196010244 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246196010245 homotrimer interaction site [polypeptide binding]; other site 246196010246 putative active site [active] 246196010247 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196010248 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196010249 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196010250 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 246196010251 substrate binding site [chemical binding]; other site 246196010252 ATP binding site [chemical binding]; other site 246196010253 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 246196010254 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 246196010255 dimer interface [polypeptide binding]; other site 246196010256 active site 246196010257 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196010258 substrate binding site [chemical binding]; other site 246196010259 catalytic residue [active] 246196010260 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 246196010261 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196010262 active site 246196010263 putative substrate binding pocket [chemical binding]; other site 246196010264 Entner-Doudoroff aldolase; Region: eda; TIGR01182 246196010265 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 246196010266 active site 246196010267 intersubunit interface [polypeptide binding]; other site 246196010268 catalytic residue [active] 246196010269 fructuronate transporter; Provisional; Region: PRK10034; cl15264 246196010270 GntP family permease; Region: GntP_permease; pfam02447 246196010271 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 246196010272 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 246196010273 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246196010274 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 246196010275 23S rRNA binding site [nucleotide binding]; other site 246196010276 L21 binding site [polypeptide binding]; other site 246196010277 L13 binding site [polypeptide binding]; other site 246196010278 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 246196010279 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 246196010280 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 246196010281 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 246196010282 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 246196010283 CrcB-like protein; Region: CRCB; cl09114 246196010284 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 246196010285 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 246196010286 dimer interface [polypeptide binding]; other site 246196010287 putative anticodon binding site; other site 246196010288 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246196010289 motif 1; other site 246196010290 dimer interface [polypeptide binding]; other site 246196010291 active site 246196010292 motif 2; other site 246196010293 motif 3; other site 246196010294 Putative esterase; Region: Esterase; pfam00756 246196010295 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196010296 CHAT domain; Region: CHAT; cl19248 246196010297 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 246196010298 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 246196010299 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 246196010300 short chain dehydrogenase; Validated; Region: PRK08264 246196010301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010302 NAD(P) binding site [chemical binding]; other site 246196010303 active site 246196010304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010306 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196010307 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 246196010308 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246196010309 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246196010310 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 246196010311 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 246196010312 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010313 Ligand Binding Site [chemical binding]; other site 246196010314 acyl-CoA thioesterase II; Region: tesB; TIGR00189 246196010315 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196010316 active site 246196010317 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196010318 catalytic triad [active] 246196010319 dimer interface [polypeptide binding]; other site 246196010320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196010322 putative substrate translocation pore; other site 246196010323 excinuclease ABC subunit B; Provisional; Region: PRK05298 246196010324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196010325 ATP binding site [chemical binding]; other site 246196010326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196010327 nucleotide binding region [chemical binding]; other site 246196010328 ATP-binding site [chemical binding]; other site 246196010329 Ultra-violet resistance protein B; Region: UvrB; pfam12344 246196010330 UvrB/uvrC motif; Region: UVR; pfam02151 246196010331 Protein of unknown function (DUF402); Region: DUF402; cl00979 246196010332 Glutaminase; Region: Glutaminase; cl00907 246196010333 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196010334 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196010335 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196010336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196010337 DNA-binding site [nucleotide binding]; DNA binding site 246196010338 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196010339 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196010340 classical (c) SDRs; Region: SDR_c; cd05233 246196010341 NAD(P) binding site [chemical binding]; other site 246196010342 active site 246196010343 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 246196010344 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196010345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010346 NAD(P) binding site [chemical binding]; other site 246196010347 active site 246196010348 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196010349 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196010350 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196010351 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196010352 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196010353 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196010354 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196010355 classical (c) SDRs; Region: SDR_c; cd05233 246196010356 NAD(P) binding site [chemical binding]; other site 246196010357 active site 246196010358 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 246196010359 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196010360 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 246196010361 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 246196010362 RNA binding site [nucleotide binding]; other site 246196010363 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 246196010364 RNA binding site [nucleotide binding]; other site 246196010365 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 246196010366 RNA binding site [nucleotide binding]; other site 246196010367 S1 RNA binding domain; Region: S1; pfam00575 246196010368 RNA binding site [nucleotide binding]; other site 246196010369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010372 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196010373 Protease prsW family; Region: PrsW-protease; pfam13367 246196010374 Uncharacterized conserved protein [Function unknown]; Region: COG2966 246196010375 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 246196010376 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 246196010377 DNA polymerase I; Provisional; Region: PRK05755 246196010378 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 246196010379 active site 246196010380 metal binding site 1 [ion binding]; metal-binding site 246196010381 putative 5' ssDNA interaction site; other site 246196010382 metal binding site 3; metal-binding site 246196010383 metal binding site 2 [ion binding]; metal-binding site 246196010384 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 246196010385 putative DNA binding site [nucleotide binding]; other site 246196010386 putative metal binding site [ion binding]; other site 246196010387 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 246196010388 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 246196010389 active site 246196010390 DNA binding site [nucleotide binding] 246196010391 catalytic site [active] 246196010392 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 246196010393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196010394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196010395 dimerization interface [polypeptide binding]; other site 246196010396 hypothetical protein; Provisional; Region: PRK06185 246196010397 hypothetical protein; Provisional; Region: PRK07538 246196010398 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196010399 Probable pheophorbidase; Region: PLN02965; cl17657 246196010400 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 246196010401 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196010402 lipid-transfer protein; Provisional; Region: PRK06059 246196010403 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196010404 active site 246196010405 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 246196010406 Phosphotransferase enzyme family; Region: APH; pfam01636 246196010407 Ecdysteroid kinase; Region: EcKinase; cl17738 246196010408 tyramine oxidase; Provisional; Region: tynA; PRK11504 246196010409 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 246196010410 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 246196010411 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 246196010412 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 246196010413 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 246196010414 substrate binding pocket [chemical binding]; other site 246196010415 catalytic triad [active] 246196010416 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196010417 active site 246196010418 dimer interface [polypeptide binding]; other site 246196010419 non-prolyl cis peptide bond; other site 246196010420 insertion regions; other site 246196010421 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196010422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196010423 substrate binding pocket [chemical binding]; other site 246196010424 membrane-bound complex binding site; other site 246196010425 hinge residues; other site 246196010426 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196010427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196010428 Walker A/P-loop; other site 246196010429 ATP binding site [chemical binding]; other site 246196010430 Q-loop/lid; other site 246196010431 ABC transporter signature motif; other site 246196010432 Walker B; other site 246196010433 D-loop; other site 246196010434 H-loop/switch region; other site 246196010435 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196010436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196010437 dimer interface [polypeptide binding]; other site 246196010438 conserved gate region; other site 246196010439 putative PBP binding loops; other site 246196010440 ABC-ATPase subunit interface; other site 246196010441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196010442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196010443 DNA binding site [nucleotide binding] 246196010444 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 246196010445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196010446 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196010447 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 246196010448 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246196010449 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 246196010450 Ligand binding site; other site 246196010451 Putative Catalytic site; other site 246196010452 DXD motif; other site 246196010453 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 246196010454 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 246196010455 putative active site [active] 246196010456 catalytic triad [active] 246196010457 putative dimer interface [polypeptide binding]; other site 246196010458 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196010459 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 246196010460 active site 246196010461 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 246196010462 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 246196010463 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 246196010464 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 246196010465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196010466 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196010467 Walker A motif; other site 246196010468 ATP binding site [chemical binding]; other site 246196010469 Walker B motif; other site 246196010470 arginine finger; other site 246196010471 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246196010472 Protein of unknown function DUF58; Region: DUF58; pfam01882 246196010473 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 246196010474 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 246196010475 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 246196010476 active site 246196010477 iron coordination sites [ion binding]; other site 246196010478 substrate binding pocket [chemical binding]; other site 246196010479 precorrin-3B synthase; Region: CobG; TIGR02435 246196010480 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196010481 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196010482 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 246196010483 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 246196010484 active site 246196010485 SAM binding site [chemical binding]; other site 246196010486 homodimer interface [polypeptide binding]; other site 246196010487 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 246196010488 active site 246196010489 SAM binding site [chemical binding]; other site 246196010490 homodimer interface [polypeptide binding]; other site 246196010491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010493 Phosphotransferase enzyme family; Region: APH; pfam01636 246196010494 Ecdysteroid kinase; Region: EcKinase; cl17738 246196010495 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 246196010496 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 246196010497 active site 246196010498 SAM binding site [chemical binding]; other site 246196010499 homodimer interface [polypeptide binding]; other site 246196010500 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 246196010501 active site 246196010502 putative homodimer interface [polypeptide binding]; other site 246196010503 SAM binding site [chemical binding]; other site 246196010504 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 246196010505 short chain dehydrogenase; Region: adh_short; pfam00106 246196010506 classical (c) SDRs; Region: SDR_c; cd05233 246196010507 NAD(P) binding site [chemical binding]; other site 246196010508 active site 246196010509 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196010510 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196010511 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196010512 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 246196010513 active site 246196010514 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 246196010515 dimer interface [polypeptide binding]; other site 246196010516 metal binding site [ion binding]; metal-binding site 246196010517 5'-3' exonuclease; Region: 53EXOc; smart00475 246196010518 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 246196010519 active site 246196010520 metal binding site 1 [ion binding]; metal-binding site 246196010521 putative 5' ssDNA interaction site; other site 246196010522 metal binding site 3; metal-binding site 246196010523 metal binding site 2 [ion binding]; metal-binding site 246196010524 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 246196010525 putative DNA binding site [nucleotide binding]; other site 246196010526 putative metal binding site [ion binding]; other site 246196010527 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 246196010528 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 246196010529 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246196010530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196010531 ATP binding site [chemical binding]; other site 246196010532 putative Mg++ binding site [ion binding]; other site 246196010533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196010534 nucleotide binding region [chemical binding]; other site 246196010535 ATP-binding site [chemical binding]; other site 246196010536 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 246196010537 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 246196010538 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 246196010539 Predicted transcriptional regulator [Transcription]; Region: COG2378 246196010540 WYL domain; Region: WYL; pfam13280 246196010541 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 246196010542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196010543 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196010544 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 246196010545 Protease prsW family; Region: PrsW-protease; pfam13367 246196010546 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 246196010547 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 246196010548 active site 246196010549 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 246196010550 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 246196010551 active site 246196010552 Pup-like protein; Region: Pup; pfam05639 246196010553 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 246196010554 ectoine hydroxylase; Region: ectoine_ThpD; TIGR02408 246196010555 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 246196010556 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196010557 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196010558 inhibitor-cofactor binding pocket; inhibition site 246196010559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196010560 catalytic residue [active] 246196010561 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196010562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196010563 Coenzyme A binding pocket [chemical binding]; other site 246196010564 proteasome ATPase; Region: pup_AAA; TIGR03689 246196010565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196010566 Walker A motif; other site 246196010567 ATP binding site [chemical binding]; other site 246196010568 Walker B motif; other site 246196010569 arginine finger; other site 246196010570 Ras GTPase Activating Domain; Region: RasGAP; cl02569 246196010571 Protein of unknown function (DUF503); Region: DUF503; pfam04456 246196010572 tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801 246196010573 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 246196010574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196010575 S-adenosylmethionine binding site [chemical binding]; other site 246196010576 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 246196010577 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246196010578 DinB superfamily; Region: DinB_2; pfam12867 246196010579 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196010580 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196010581 classical (c) SDRs; Region: SDR_c; cd05233 246196010582 NAD(P) binding site [chemical binding]; other site 246196010583 active site 246196010584 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196010585 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196010586 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 246196010587 NAD binding site [chemical binding]; other site 246196010588 substrate binding site [chemical binding]; other site 246196010589 catalytic Zn binding site [ion binding]; other site 246196010590 structural Zn binding site [ion binding]; other site 246196010591 NnrU protein; Region: NnrU; cl17713 246196010592 Protein of unknown function (DUF664); Region: DUF664; pfam04978 246196010593 Condensation domain; Region: Condensation; cl19241 246196010594 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196010595 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 246196010596 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 246196010597 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196010598 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 246196010599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196010600 motif II; other site 246196010601 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 246196010602 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 246196010603 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 246196010604 nickel binding site [ion binding]; other site 246196010605 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 246196010606 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 246196010607 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 246196010608 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 246196010609 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 246196010610 FAD binding pocket [chemical binding]; other site 246196010611 FAD binding motif [chemical binding]; other site 246196010612 phosphate binding motif [ion binding]; other site 246196010613 beta-alpha-beta structure motif; other site 246196010614 NAD binding pocket [chemical binding]; other site 246196010615 Iron coordination center [ion binding]; other site 246196010616 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 246196010617 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246196010618 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246196010619 putative dimer interface [polypeptide binding]; other site 246196010620 phosphoenolpyruvate synthase; Validated; Region: PRK06464 246196010621 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 246196010622 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 246196010623 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246196010624 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196010625 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196010626 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 246196010627 30S subunit binding site; other site 246196010628 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010629 Ligand Binding Site [chemical binding]; other site 246196010630 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010631 Ligand Binding Site [chemical binding]; other site 246196010632 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 246196010633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010634 Ligand Binding Site [chemical binding]; other site 246196010635 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010636 Ligand Binding Site [chemical binding]; other site 246196010637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010638 Ligand Binding Site [chemical binding]; other site 246196010639 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196010640 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246196010641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246196010642 Histidine kinase; Region: HisKA_3; pfam07730 246196010643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196010644 ATP binding site [chemical binding]; other site 246196010645 Mg2+ binding site [ion binding]; other site 246196010646 G-X-G motif; other site 246196010647 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 246196010648 AAA domain; Region: AAA_17; cl19128 246196010649 AAA domain; Region: AAA_33; pfam13671 246196010650 Nitroreductase family; Region: Nitroreductase; pfam00881 246196010651 dimer interface [polypeptide binding]; other site 246196010652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196010653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196010654 active site 246196010655 phosphorylation site [posttranslational modification] 246196010656 intermolecular recognition site; other site 246196010657 dimerization interface [polypeptide binding]; other site 246196010658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196010659 DNA binding residues [nucleotide binding] 246196010660 dimerization interface [polypeptide binding]; other site 246196010661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010662 Ligand Binding Site [chemical binding]; other site 246196010663 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010664 Ligand Binding Site [chemical binding]; other site 246196010665 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196010666 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196010667 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246196010668 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 246196010669 putative substrate binding site [chemical binding]; other site 246196010670 putative ATP binding site [chemical binding]; other site 246196010671 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010672 Ligand Binding Site [chemical binding]; other site 246196010673 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196010674 Ligand Binding Site [chemical binding]; other site 246196010675 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196010676 dimer interface [polypeptide binding]; other site 246196010677 Nitroreductase family; Region: Nitroreductase; pfam00881 246196010678 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246196010679 active site 246196010680 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 246196010681 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246196010682 active site 246196010683 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 246196010684 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 246196010685 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 246196010686 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 246196010687 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196010688 dimer interface [polypeptide binding]; other site 246196010689 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196010690 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196010691 active site 246196010692 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 246196010693 dimer interface [polypeptide binding]; other site 246196010694 ligand binding site [chemical binding]; other site 246196010695 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196010696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196010697 DNA-binding site [nucleotide binding]; DNA binding site 246196010698 FCD domain; Region: FCD; pfam07729 246196010699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010703 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 246196010704 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 246196010705 putative active site [active] 246196010706 putative substrate binding site [chemical binding]; other site 246196010707 putative FMN binding site [chemical binding]; other site 246196010708 putative catalytic residues [active] 246196010709 pyruvate dehydrogenase; Provisional; Region: PRK09124 246196010710 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246196010711 PYR/PP interface [polypeptide binding]; other site 246196010712 dimer interface [polypeptide binding]; other site 246196010713 tetramer interface [polypeptide binding]; other site 246196010714 TPP binding site [chemical binding]; other site 246196010715 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196010716 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 246196010717 TPP-binding site [chemical binding]; other site 246196010718 HTH domain; Region: HTH_11; pfam08279 246196010719 WYL domain; Region: WYL; pfam13280 246196010720 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196010721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196010722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196010723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196010724 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196010725 dimerization interface [polypeptide binding]; other site 246196010726 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 246196010727 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196010728 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196010729 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196010730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010731 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 246196010732 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 246196010733 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196010734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196010735 DNA-binding site [nucleotide binding]; DNA binding site 246196010736 FCD domain; Region: FCD; pfam07729 246196010737 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196010738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196010739 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196010740 active site 246196010741 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196010742 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196010743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010744 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196010745 putative substrate translocation pore; other site 246196010746 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 246196010747 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196010748 acyl-activating enzyme (AAE) consensus motif; other site 246196010749 AMP binding site [chemical binding]; other site 246196010750 active site 246196010751 CoA binding site [chemical binding]; other site 246196010752 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 246196010753 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196010754 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 246196010755 AsnC family; Region: AsnC_trans_reg; pfam01037 246196010756 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196010757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196010758 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 246196010759 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 246196010760 metal binding site [ion binding]; metal-binding site 246196010761 dimer interface [polypeptide binding]; other site 246196010762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010763 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196010764 putative substrate translocation pore; other site 246196010765 Putative cyclase; Region: Cyclase; pfam04199 246196010766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010767 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196010768 putative substrate translocation pore; other site 246196010769 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196010770 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 246196010771 dimer interface [polypeptide binding]; other site 246196010772 [2Fe-2S] cluster binding site [ion binding]; other site 246196010773 short chain dehydrogenase; Provisional; Region: PRK06125 246196010774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010775 NAD(P) binding site [chemical binding]; other site 246196010776 active site 246196010777 allantoate amidohydrolase; Reviewed; Region: PRK09290 246196010778 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 246196010779 active site 246196010780 metal binding site [ion binding]; metal-binding site 246196010781 dimer interface [polypeptide binding]; other site 246196010782 phenylhydantoinase; Validated; Region: PRK08323 246196010783 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 246196010784 tetramer interface [polypeptide binding]; other site 246196010785 active site 246196010786 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196010787 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 246196010788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196010789 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196010790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196010791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196010792 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 246196010793 ligand binding site [chemical binding]; other site 246196010794 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196010795 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196010796 Walker A/P-loop; other site 246196010797 ATP binding site [chemical binding]; other site 246196010798 Q-loop/lid; other site 246196010799 ABC transporter signature motif; other site 246196010800 Walker B; other site 246196010801 D-loop; other site 246196010802 H-loop/switch region; other site 246196010803 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196010804 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196010805 TM-ABC transporter signature motif; other site 246196010806 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 246196010807 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196010808 putative NAD(P) binding site [chemical binding]; other site 246196010809 catalytic Zn binding site [ion binding]; other site 246196010810 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 246196010811 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196010812 classical (c) SDRs; Region: SDR_c; cd05233 246196010813 NAD(P) binding site [chemical binding]; other site 246196010814 active site 246196010815 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196010816 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196010817 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196010818 oxidoreductase; Region: PLN02485 246196010819 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196010820 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196010821 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196010822 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196010823 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196010824 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196010825 catalytic loop [active] 246196010826 iron binding site [ion binding]; other site 246196010827 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196010828 active site 246196010829 Sulfate transporter family; Region: Sulfate_transp; cl19250 246196010830 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 246196010831 phenylhydantoinase; Validated; Region: PRK08323 246196010832 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 246196010833 tetramer interface [polypeptide binding]; other site 246196010834 active site 246196010835 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196010836 allantoate amidohydrolase; Reviewed; Region: PRK09290 246196010837 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 246196010838 active site 246196010839 metal binding site [ion binding]; metal-binding site 246196010840 dimer interface [polypeptide binding]; other site 246196010841 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196010842 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246196010843 active site 246196010844 NTP binding site [chemical binding]; other site 246196010845 metal binding triad [ion binding]; metal-binding site 246196010846 antibiotic binding site [chemical binding]; other site 246196010847 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196010848 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196010849 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 246196010850 acyl-activating enzyme (AAE) consensus motif; other site 246196010851 acyl-activating enzyme (AAE) consensus motif; other site 246196010852 putative AMP binding site [chemical binding]; other site 246196010853 putative active site [active] 246196010854 CoA binding site [chemical binding]; other site 246196010855 putative CoA binding site [chemical binding]; other site 246196010856 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196010857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196010858 substrate binding site [chemical binding]; other site 246196010859 oxyanion hole (OAH) forming residues; other site 246196010860 trimer interface [polypeptide binding]; other site 246196010861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010863 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 246196010864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196010865 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 246196010866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196010871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196010872 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196010873 dimerization interface [polypeptide binding]; other site 246196010874 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196010875 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 246196010876 putative NAD(P) binding site [chemical binding]; other site 246196010877 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196010878 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196010879 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196010880 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196010881 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196010882 putative NAD(P) binding site [chemical binding]; other site 246196010883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010886 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 246196010887 NAD(P) binding site [chemical binding]; other site 246196010888 active site 246196010889 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 246196010890 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 246196010891 active site 246196010892 oxalacetate binding site [chemical binding]; other site 246196010893 citrylCoA binding site [chemical binding]; other site 246196010894 coenzyme A binding site [chemical binding]; other site 246196010895 catalytic triad [active] 246196010896 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196010897 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 246196010898 acyl-activating enzyme (AAE) consensus motif; other site 246196010899 putative AMP binding site [chemical binding]; other site 246196010900 putative active site [active] 246196010901 putative CoA binding site [chemical binding]; other site 246196010902 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196010903 Pseudomonas putida vanillin dehydrogenase-like; Region: ALDH_VaniDH_like; cd07150 246196010904 NAD(P) binding site [chemical binding]; other site 246196010905 catalytic residues [active] 246196010906 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 246196010907 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 246196010908 catalytic Zn binding site [ion binding]; other site 246196010909 NAD binding site [chemical binding]; other site 246196010910 structural Zn binding site [ion binding]; other site 246196010911 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 246196010912 putative FMN binding site [chemical binding]; other site 246196010913 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 246196010914 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 246196010915 active site 246196010916 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196010917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196010918 DNA-binding site [nucleotide binding]; DNA binding site 246196010919 FCD domain; Region: FCD; pfam07729 246196010920 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 246196010921 active site 246196010922 GAF domain; Region: GAF_2; pfam13185 246196010923 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 246196010924 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196010925 Muconolactone delta-isomerase; Region: MIase; cl01992 246196010926 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196010927 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 246196010928 Putative cyclase; Region: Cyclase; pfam04199 246196010929 benzoate transport; Region: 2A0115; TIGR00895 246196010930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010931 putative substrate translocation pore; other site 246196010932 AAA ATPase domain; Region: AAA_16; pfam13191 246196010933 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 246196010934 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196010935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196010936 DNA binding residues [nucleotide binding] 246196010937 dimerization interface [polypeptide binding]; other site 246196010938 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196010939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010940 NAD(P) binding site [chemical binding]; other site 246196010941 active site 246196010942 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196010943 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196010944 NAD(P) binding site [chemical binding]; other site 246196010945 active site 246196010946 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196010947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196010948 DNA-binding site [nucleotide binding]; DNA binding site 246196010949 FCD domain; Region: FCD; pfam07729 246196010950 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196010951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196010952 putative substrate translocation pore; other site 246196010953 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 246196010954 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 246196010955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196010956 motif II; other site 246196010957 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246196010958 homotrimer interaction site [polypeptide binding]; other site 246196010959 putative active site [active] 246196010960 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196010961 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 246196010962 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196010963 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196010964 putative NAD(P) binding site [chemical binding]; other site 246196010965 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196010966 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196010967 acyl-activating enzyme (AAE) consensus motif; other site 246196010968 putative AMP binding site [chemical binding]; other site 246196010969 putative active site [active] 246196010970 putative CoA binding site [chemical binding]; other site 246196010971 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246196010972 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 246196010973 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196010974 putative NAD(P) binding site [chemical binding]; other site 246196010975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196010976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196010977 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196010978 Winged helix-turn helix; Region: HTH_29; pfam13551 246196010979 Homeodomain-like domain; Region: HTH_32; pfam13565 246196010980 DDE superfamily endonuclease; Region: DDE_3; cl19249 246196010981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196010982 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196010983 NAD(P) binding site [chemical binding]; other site 246196010984 active site 246196010985 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 246196010986 CoA binding domain; Region: CoA_binding_2; pfam13380 246196010987 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 246196010988 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 246196010989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196010990 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196010991 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196010992 active site 246196010993 enoyl-CoA hydratase; Provisional; Region: PRK08138 246196010994 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196010995 substrate binding site [chemical binding]; other site 246196010996 oxyanion hole (OAH) forming residues; other site 246196010997 trimer interface [polypeptide binding]; other site 246196010998 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 246196010999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011000 putative substrate translocation pore; other site 246196011001 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196011002 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196011003 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196011004 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196011005 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196011006 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196011007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011008 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196011009 active site 246196011010 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196011011 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196011012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011013 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196011014 putative substrate translocation pore; other site 246196011015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196011016 Transposase; Region: HTH_Tnp_1; cl17663 246196011017 putative transposase OrfB; Reviewed; Region: PHA02517 246196011018 Integrase core domain; Region: rve; pfam00665 246196011019 Integrase core domain; Region: rve_3; cl15866 246196011020 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196011021 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196011022 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196011023 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196011024 active site 246196011025 non-prolyl cis peptide bond; other site 246196011026 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196011027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196011028 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196011029 active site 246196011030 catalytic tetrad [active] 246196011031 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196011032 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011033 active site 246196011034 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196011035 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196011036 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196011037 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011038 active site 246196011039 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196011040 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011041 Walker A/P-loop; other site 246196011042 ATP binding site [chemical binding]; other site 246196011043 Q-loop/lid; other site 246196011044 ABC transporter signature motif; other site 246196011045 Walker B; other site 246196011046 D-loop; other site 246196011047 H-loop/switch region; other site 246196011048 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 246196011049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011050 Walker A/P-loop; other site 246196011051 ATP binding site [chemical binding]; other site 246196011052 Q-loop/lid; other site 246196011053 ABC transporter signature motif; other site 246196011054 Walker B; other site 246196011055 D-loop; other site 246196011056 H-loop/switch region; other site 246196011057 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196011058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196011059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011060 dimer interface [polypeptide binding]; other site 246196011061 conserved gate region; other site 246196011062 putative PBP binding loops; other site 246196011063 ABC-ATPase subunit interface; other site 246196011064 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196011065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011066 dimer interface [polypeptide binding]; other site 246196011067 conserved gate region; other site 246196011068 putative PBP binding loops; other site 246196011069 ABC-ATPase subunit interface; other site 246196011070 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196011071 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 246196011072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196011073 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 246196011074 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011075 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196011076 active site 246196011077 dimer interface [polypeptide binding]; other site 246196011078 non-prolyl cis peptide bond; other site 246196011079 insertion regions; other site 246196011080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196011082 putative substrate translocation pore; other site 246196011083 putative transposase OrfB; Reviewed; Region: PHA02517 246196011084 Integrase core domain; Region: rve; pfam00665 246196011085 Integrase core domain; Region: rve_3; cl15866 246196011086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196011087 Transposase; Region: HTH_Tnp_1; cl17663 246196011088 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196011089 catalytic core [active] 246196011090 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 246196011091 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 246196011092 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 246196011093 ligand binding site [chemical binding]; other site 246196011094 homodimer interface [polypeptide binding]; other site 246196011095 NAD(P) binding site [chemical binding]; other site 246196011096 trimer interface B [polypeptide binding]; other site 246196011097 trimer interface A [polypeptide binding]; other site 246196011098 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 246196011099 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246196011100 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196011101 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196011102 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196011103 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 246196011104 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 246196011105 acyl-activating enzyme (AAE) consensus motif; other site 246196011106 putative AMP binding site [chemical binding]; other site 246196011107 putative active site [active] 246196011108 putative CoA binding site [chemical binding]; other site 246196011109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196011110 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011111 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 246196011112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011113 substrate binding site [chemical binding]; other site 246196011114 oxyanion hole (OAH) forming residues; other site 246196011115 trimer interface [polypeptide binding]; other site 246196011116 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 246196011117 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196011118 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196011119 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246196011120 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196011121 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196011122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011123 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196011124 NAD(P) binding site [chemical binding]; other site 246196011125 active site 246196011126 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196011127 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011128 active site 246196011129 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 246196011130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011131 substrate binding site [chemical binding]; other site 246196011132 oxyanion hole (OAH) forming residues; other site 246196011133 trimer interface [polypeptide binding]; other site 246196011134 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196011135 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196011136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196011137 DNA-binding site [nucleotide binding]; DNA binding site 246196011138 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196011139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011140 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196011141 putative substrate translocation pore; other site 246196011142 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196011143 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 246196011144 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196011145 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 246196011146 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 246196011147 classical (c) SDRs; Region: SDR_c; cd05233 246196011148 NAD(P) binding site [chemical binding]; other site 246196011149 active site 246196011150 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 246196011151 catalytic triad [active] 246196011152 conserved cis-peptide bond; other site 246196011153 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196011154 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196011155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196011156 S-adenosylmethionine binding site [chemical binding]; other site 246196011157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011158 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 246196011159 putative active site [active] 246196011160 putative catalytic site [active] 246196011161 Transposase; Region: HTH_Tnp_1; cl17663 246196011162 Ribosomal protein L11, RNA binding domain; Region: Ribosomal_L11; pfam00298 246196011163 Integrase core domain; Region: rve; pfam00665 246196011164 Integrase core domain; Region: rve_3; pfam13683 246196011165 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 246196011166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011167 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 246196011168 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 246196011169 putative active site [active] 246196011170 catalytic triad [active] 246196011171 putative dimer interface [polypeptide binding]; other site 246196011172 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196011173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196011174 DNA-binding site [nucleotide binding]; DNA binding site 246196011175 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196011176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196011177 homodimer interface [polypeptide binding]; other site 246196011178 catalytic residue [active] 246196011179 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196011180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196011181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011182 Uncharacterized conserved protein [Function unknown]; Region: COG5470 246196011183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196011184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196011185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196011186 dimerization interface [polypeptide binding]; other site 246196011187 Cupin domain; Region: Cupin_2; cl17218 246196011188 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 246196011189 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 246196011190 NADP binding site [chemical binding]; other site 246196011191 dimer interface [polypeptide binding]; other site 246196011192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196011194 putative substrate translocation pore; other site 246196011195 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196011196 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196011197 acetaldehyde dehydrogenase; Validated; Region: PRK08300 246196011198 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 246196011199 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 246196011200 4-hydroxy-2-oxovalerate aldolase; Region: 4OH_2_O_val_ald; TIGR03217 246196011201 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 246196011202 active site 246196011203 catalytic residues [active] 246196011204 metal binding site [ion binding]; metal-binding site 246196011205 DmpG-like communication domain; Region: DmpG_comm; pfam07836 246196011206 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196011207 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196011208 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196011209 FMN-binding pocket [chemical binding]; other site 246196011210 flavin binding motif; other site 246196011211 phosphate binding motif [ion binding]; other site 246196011212 beta-alpha-beta structure motif; other site 246196011213 NAD binding pocket [chemical binding]; other site 246196011214 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196011215 catalytic loop [active] 246196011216 iron binding site [ion binding]; other site 246196011217 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196011218 Transposase, Mutator family; Region: Transposase_mut; pfam00872 246196011219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 246196011220 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 246196011221 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; pfam02899 246196011222 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196011223 active site 246196011224 DNA binding site [nucleotide binding] 246196011225 Int/Topo IB signature motif; other site 246196011226 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 246196011227 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246196011228 active site 246196011229 DNA binding site [nucleotide binding] 246196011230 Int/Topo IB signature motif; other site 246196011231 Transposase, Mutator family; Region: Transposase_mut; cl19537 246196011232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 246196011233 Protein of unknown function (DUF993); Region: DUF993; pfam06187 246196011234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196011235 classical (c) SDRs; Region: SDR_c; cd05233 246196011236 NAD(P) binding site [chemical binding]; other site 246196011237 active site 246196011238 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196011239 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011240 substrate binding site [chemical binding]; other site 246196011241 oxyanion hole (OAH) forming residues; other site 246196011242 trimer interface [polypeptide binding]; other site 246196011243 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 246196011244 NAD(P) binding site [chemical binding]; other site 246196011245 catalytic residues [active] 246196011246 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196011247 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011248 active site 246196011249 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 246196011250 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196011251 NAD binding site [chemical binding]; other site 246196011252 catalytic Zn binding site [ion binding]; other site 246196011253 substrate binding site [chemical binding]; other site 246196011254 structural Zn binding site [ion binding]; other site 246196011255 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 246196011256 Coenzyme A transferase; Region: CoA_trans; smart00882 246196011257 Coenzyme A transferase; Region: CoA_trans; cl17247 246196011258 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196011259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011260 NAD(P) binding site [chemical binding]; other site 246196011261 active site 246196011262 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 246196011263 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196011264 Walker A/P-loop; other site 246196011265 ATP binding site [chemical binding]; other site 246196011266 Q-loop/lid; other site 246196011267 ABC transporter signature motif; other site 246196011268 Walker B; other site 246196011269 D-loop; other site 246196011270 H-loop/switch region; other site 246196011271 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246196011272 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196011273 TM-ABC transporter signature motif; other site 246196011274 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 246196011275 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 246196011276 ligand binding site [chemical binding]; other site 246196011277 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196011278 active site 2 [active] 246196011279 active site 1 [active] 246196011280 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196011281 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196011282 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196011283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196011284 dimerization interface [polypeptide binding]; other site 246196011285 putative DNA binding site [nucleotide binding]; other site 246196011286 putative Zn2+ binding site [ion binding]; other site 246196011287 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 246196011288 putative hydrophobic ligand binding site [chemical binding]; other site 246196011289 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246196011290 Predicted membrane protein [Function unknown]; Region: COG3918 246196011291 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 246196011292 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 246196011293 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 246196011294 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 246196011295 homodimer interface [polypeptide binding]; other site 246196011296 putative metal binding site [ion binding]; other site 246196011297 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 246196011298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011299 putative substrate translocation pore; other site 246196011300 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 246196011301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196011302 active site 246196011303 motif I; other site 246196011304 motif II; other site 246196011305 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196011306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011307 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 246196011308 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 246196011309 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 246196011310 substrate binding pocket [chemical binding]; other site 246196011311 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 246196011312 B12 binding site [chemical binding]; other site 246196011313 cobalt ligand [ion binding]; other site 246196011314 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 246196011315 PAC2 family; Region: PAC2; pfam09754 246196011316 Uncharacterized conserved protein [Function unknown]; Region: COG5361 246196011317 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 246196011318 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 246196011319 short chain dehydrogenase; Provisional; Region: PRK05872 246196011320 classical (c) SDRs; Region: SDR_c; cd05233 246196011321 NAD(P) binding site [chemical binding]; other site 246196011322 active site 246196011323 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 246196011324 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246196011325 active site 246196011326 HIGH motif; other site 246196011327 KMSKS motif; other site 246196011328 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 246196011329 putative tRNA binding surface [nucleotide binding]; other site 246196011330 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 246196011331 active site 246196011332 conserved hypothetical protein; Region: TIGR03843 246196011333 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 246196011334 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196011335 catalytic core [active] 246196011336 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 246196011337 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 246196011338 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 246196011339 quinone interaction residues [chemical binding]; other site 246196011340 active site 246196011341 catalytic residues [active] 246196011342 FMN binding site [chemical binding]; other site 246196011343 substrate binding site [chemical binding]; other site 246196011344 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 246196011345 substrate binding site [chemical binding]; other site 246196011346 hypothetical protein; Provisional; Region: PRK07906 246196011347 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 246196011348 putative metal binding site [ion binding]; other site 246196011349 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196011350 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 246196011351 Subtilase family; Region: Peptidase_S8; pfam00082 246196011352 active site 246196011353 catalytic triad [active] 246196011354 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 246196011355 putative heme binding pocket [chemical binding]; other site 246196011356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196011357 Walker A motif; other site 246196011358 ATP binding site [chemical binding]; other site 246196011359 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 246196011360 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196011361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196011362 DNA binding residues [nucleotide binding] 246196011363 dimerization interface [polypeptide binding]; other site 246196011364 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196011365 Ligand Binding Site [chemical binding]; other site 246196011366 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 246196011367 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 246196011368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 246196011369 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 246196011370 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 246196011371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196011372 putative active site [active] 246196011373 heme pocket [chemical binding]; other site 246196011374 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 246196011375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196011376 ATP binding site [chemical binding]; other site 246196011377 Mg2+ binding site [ion binding]; other site 246196011378 G-X-G motif; other site 246196011379 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 246196011380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196011381 active site 246196011382 phosphorylation site [posttranslational modification] 246196011383 intermolecular recognition site; other site 246196011384 dimerization interface [polypeptide binding]; other site 246196011385 Transcriptional regulator; Region: CitT; pfam12431 246196011386 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196011387 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 246196011388 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 246196011389 catalytic triad [active] 246196011390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196011391 active site 246196011392 ribonuclease E; Reviewed; Region: rne; PRK10811 246196011393 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 246196011394 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 246196011395 Flagellar assembly protein FliH; Region: FliH; cl19405 246196011396 Predicted integral membrane protein [Function unknown]; Region: COG0762 246196011397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 246196011398 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 246196011399 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196011400 catalytic residue [active] 246196011401 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 246196011402 cell division protein FtsZ; Validated; Region: PRK09330 246196011403 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 246196011404 nucleotide binding site [chemical binding]; other site 246196011405 SulA interaction site; other site 246196011406 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 246196011407 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 246196011408 Cell division protein FtsQ; Region: FtsQ; pfam03799 246196011409 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 246196011410 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246196011411 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196011412 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196011413 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 246196011414 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 246196011415 active site 246196011416 homodimer interface [polypeptide binding]; other site 246196011417 cell division protein FtsW; Region: ftsW; TIGR02614 246196011418 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 246196011419 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196011420 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196011421 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 246196011422 Mg++ binding site [ion binding]; other site 246196011423 putative catalytic motif [active] 246196011424 putative substrate binding site [chemical binding]; other site 246196011425 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 246196011426 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246196011427 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196011428 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196011429 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 246196011430 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196011431 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246196011432 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 246196011433 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 246196011434 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196011435 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 246196011436 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 246196011437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 246196011438 MraZ protein; Region: MraZ; pfam02381 246196011439 MraZ protein; Region: MraZ; pfam02381 246196011440 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 246196011441 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246196011442 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196011443 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246196011444 substrate binding pocket [chemical binding]; other site 246196011445 chain length determination region; other site 246196011446 substrate-Mg2+ binding site; other site 246196011447 catalytic residues [active] 246196011448 aspartate-rich region 1; other site 246196011449 active site lid residues [active] 246196011450 aspartate-rich region 2; other site 246196011451 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 246196011452 CpeS-like protein; Region: CpeS; pfam09367 246196011453 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196011454 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246196011455 active site 246196011456 ATP binding site [chemical binding]; other site 246196011457 substrate binding site [chemical binding]; other site 246196011458 activation loop (A-loop); other site 246196011459 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 246196011460 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 246196011461 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196011462 putative acyl-acceptor binding pocket; other site 246196011463 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 246196011464 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246196011465 P loop; other site 246196011466 Nucleotide binding site [chemical binding]; other site 246196011467 DTAP/Switch II; other site 246196011468 Switch I; other site 246196011469 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 246196011470 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 246196011471 putative hydrophobic ligand binding site [chemical binding]; other site 246196011472 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246196011473 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 246196011474 acyl-activating enzyme (AAE) consensus motif; other site 246196011475 putative AMP binding site [chemical binding]; other site 246196011476 putative active site [active] 246196011477 putative CoA binding site [chemical binding]; other site 246196011478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196011479 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196011480 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246196011481 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246196011482 NlpC/P60 family; Region: NLPC_P60; pfam00877 246196011483 hypothetical protein; Validated; Region: PRK07883 246196011484 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 246196011485 active site 246196011486 catalytic site [active] 246196011487 substrate binding site [chemical binding]; other site 246196011488 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 246196011489 GIY-YIG motif/motif A; other site 246196011490 active site 246196011491 catalytic site [active] 246196011492 putative DNA binding site [nucleotide binding]; other site 246196011493 metal binding site [ion binding]; metal-binding site 246196011494 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 246196011495 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 246196011496 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 246196011497 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 246196011498 Subunit I/III interface [polypeptide binding]; other site 246196011499 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 246196011500 Cytochrome c; Region: Cytochrom_C; pfam00034 246196011501 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246196011502 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 246196011503 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246196011504 iron-sulfur cluster [ion binding]; other site 246196011505 [2Fe-2S] cluster binding site [ion binding]; other site 246196011506 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 246196011507 heme bH binding site [chemical binding]; other site 246196011508 Qi binding site; other site 246196011509 intrachain domain interface; other site 246196011510 heme bL binding site [chemical binding]; other site 246196011511 interchain domain interface [polypeptide binding]; other site 246196011512 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 246196011513 Qo binding site; other site 246196011514 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 246196011515 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196011516 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 246196011517 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 246196011518 Cupredoxin superfamily; Region: Cupredoxin; cl19115 246196011519 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 246196011520 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 246196011521 active site 246196011522 dimer interface [polypeptide binding]; other site 246196011523 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 246196011524 Ligand Binding Site [chemical binding]; other site 246196011525 Molecular Tunnel; other site 246196011526 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 246196011527 substrate binding site [chemical binding]; other site 246196011528 ATP binding site [chemical binding]; other site 246196011529 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 246196011530 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 246196011531 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 246196011532 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 246196011533 putative dimer interface [polypeptide binding]; other site 246196011534 active site pocket [active] 246196011535 putative cataytic base [active] 246196011536 cobalamin synthase; Reviewed; Region: cobS; PRK00235 246196011537 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 246196011538 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 246196011539 homodimer interface [polypeptide binding]; other site 246196011540 substrate-cofactor binding pocket; other site 246196011541 catalytic residue [active] 246196011542 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 246196011543 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 246196011544 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 246196011545 cyclase homology domain; Region: CHD; cd07302 246196011546 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196011547 nucleotidyl binding site; other site 246196011548 metal binding site [ion binding]; metal-binding site 246196011549 dimer interface [polypeptide binding]; other site 246196011550 multifunctional aminopeptidase A; Provisional; Region: PRK00913 246196011551 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 246196011552 interface (dimer of trimers) [polypeptide binding]; other site 246196011553 Substrate-binding/catalytic site; other site 246196011554 Zn-binding sites [ion binding]; other site 246196011555 short chain dehydrogenase; Validated; Region: PRK05855 246196011556 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196011557 classical (c) SDRs; Region: SDR_c; cd05233 246196011558 NAD(P) binding site [chemical binding]; other site 246196011559 active site 246196011560 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 246196011561 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246196011562 E3 interaction surface; other site 246196011563 lipoyl attachment site [posttranslational modification]; other site 246196011564 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246196011565 E3 interaction surface; other site 246196011566 lipoyl attachment site [posttranslational modification]; other site 246196011567 e3 binding domain; Region: E3_binding; pfam02817 246196011568 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246196011569 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 246196011570 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 246196011571 putative NAD(P) binding site [chemical binding]; other site 246196011572 putative active site [active] 246196011573 lipoate-protein ligase B; Provisional; Region: PRK14345 246196011574 lipoyl synthase; Provisional; Region: PRK05481 246196011575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196011576 FeS/SAM binding site; other site 246196011577 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 246196011578 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246196011579 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 246196011580 active site 246196011581 RDD family; Region: RDD; pfam06271 246196011582 glutamine synthetase, type I; Region: GlnA; TIGR00653 246196011583 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246196011584 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196011585 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 246196011586 putative active site [active] 246196011587 dimerization interface [polypeptide binding]; other site 246196011588 putative tRNAtyr binding site [nucleotide binding]; other site 246196011589 Predicted membrane protein [Function unknown]; Region: COG2259 246196011590 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 246196011591 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246196011592 metal binding triad; other site 246196011593 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 246196011594 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246196011595 metal binding triad; other site 246196011596 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 246196011597 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196011598 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246196011599 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196011600 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246196011601 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196011602 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196011603 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246196011604 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196011605 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196011606 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196011607 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246196011608 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 246196011609 oligomerization interface [polypeptide binding]; other site 246196011610 active site 246196011611 metal binding site [ion binding]; metal-binding site 246196011612 enoyl-CoA hydratase; Provisional; Region: PRK06688 246196011613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196011614 substrate binding site [chemical binding]; other site 246196011615 oxyanion hole (OAH) forming residues; other site 246196011616 trimer interface [polypeptide binding]; other site 246196011617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196011618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011619 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 246196011620 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196011621 acyl-activating enzyme (AAE) consensus motif; other site 246196011622 active site 246196011623 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 246196011624 putative active site; other site 246196011625 putative metal binding residues [ion binding]; other site 246196011626 signature motif; other site 246196011627 putative triphosphate binding site [ion binding]; other site 246196011628 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 246196011629 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 246196011630 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196011631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196011632 S-adenosylmethionine binding site [chemical binding]; other site 246196011633 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196011634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196011635 non-specific DNA binding site [nucleotide binding]; other site 246196011636 salt bridge; other site 246196011637 sequence-specific DNA binding site [nucleotide binding]; other site 246196011638 Cupin domain; Region: Cupin_2; pfam07883 246196011639 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 246196011640 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 246196011641 RNA/DNA hybrid binding site [nucleotide binding]; other site 246196011642 active site 246196011643 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196011644 catalytic core [active] 246196011645 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 246196011646 5' nucleotidase family; Region: 5_nucleotid; cl17687 246196011647 Putative zinc ribbon domain; Region: DUF164; pfam02591 246196011648 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 246196011649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 246196011650 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 246196011651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196011652 active site 246196011653 motif I; other site 246196011654 motif II; other site 246196011655 Low molecular weight phosphatase family; Region: LMWPc; cd00115 246196011656 active site 246196011657 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 246196011658 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 246196011659 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196011660 active site 246196011661 metal binding site [ion binding]; metal-binding site 246196011662 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246196011663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196011664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196011665 DNA binding residues [nucleotide binding] 246196011666 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 246196011667 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 246196011668 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246196011669 DNA binding site [nucleotide binding] 246196011670 active site 246196011671 Oxygenase, catalyzing oxidative methylation of damaged DNA; Region: Oxygenase-NA; cl17606 246196011672 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 246196011673 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246196011674 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 246196011675 dimer interface [polypeptide binding]; other site 246196011676 catalytic triad [active] 246196011677 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 246196011678 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 246196011679 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 246196011680 dimer interface [polypeptide binding]; other site 246196011681 TPP-binding site [chemical binding]; other site 246196011682 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196011683 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196011684 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246196011685 acyl carrier protein; Provisional; Region: acpP; PRK00982 246196011686 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 246196011687 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246196011688 dimer interface [polypeptide binding]; other site 246196011689 active site 246196011690 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 246196011691 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246196011692 dimer interface [polypeptide binding]; other site 246196011693 active site 246196011694 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196011695 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196011696 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 246196011697 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196011698 short chain dehydrogenase; Provisional; Region: PRK12744 246196011699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011700 NAD(P) binding site [chemical binding]; other site 246196011701 active site 246196011702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196011703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196011704 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196011705 dimerization interface [polypeptide binding]; other site 246196011706 substrate binding pocket [chemical binding]; other site 246196011707 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 246196011708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196011709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196011710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196011711 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196011712 FAD binding domain; Region: FAD_binding_4; pfam01565 246196011713 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 246196011714 diacylglycerol kinase; Reviewed; Region: PRK11914 246196011715 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246196011716 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 246196011717 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196011718 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196011719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196011720 S-adenosylmethionine binding site [chemical binding]; other site 246196011721 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 246196011722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196011723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196011724 DNA binding residues [nucleotide binding] 246196011725 dimerization interface [polypeptide binding]; other site 246196011726 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 246196011727 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196011728 NAD binding site [chemical binding]; other site 246196011729 catalytic Zn binding site [ion binding]; other site 246196011730 substrate binding site [chemical binding]; other site 246196011731 structural Zn binding site [ion binding]; other site 246196011732 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196011733 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196011734 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196011735 Short C-terminal domain; Region: SHOCT; pfam09851 246196011736 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 246196011737 hypothetical protein; Validated; Region: PRK07586 246196011738 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196011739 PYR/PP interface [polypeptide binding]; other site 246196011740 dimer interface [polypeptide binding]; other site 246196011741 TPP binding site [chemical binding]; other site 246196011742 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 246196011743 TPP-binding site [chemical binding]; other site 246196011744 dimer interface [polypeptide binding]; other site 246196011745 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196011746 nucleotide binding site [chemical binding]; other site 246196011747 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196011748 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196011749 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196011750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011751 NAD(P) binding site [chemical binding]; other site 246196011752 active site 246196011753 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196011754 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196011755 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 246196011756 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196011757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011758 dimer interface [polypeptide binding]; other site 246196011759 conserved gate region; other site 246196011760 putative PBP binding loops; other site 246196011761 ABC-ATPase subunit interface; other site 246196011762 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196011763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011764 dimer interface [polypeptide binding]; other site 246196011765 conserved gate region; other site 246196011766 putative PBP binding loops; other site 246196011767 ABC-ATPase subunit interface; other site 246196011768 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196011769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011770 Walker A/P-loop; other site 246196011771 ATP binding site [chemical binding]; other site 246196011772 Q-loop/lid; other site 246196011773 ABC transporter signature motif; other site 246196011774 Walker B; other site 246196011775 D-loop; other site 246196011776 H-loop/switch region; other site 246196011777 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196011778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011779 Walker A/P-loop; other site 246196011780 ATP binding site [chemical binding]; other site 246196011781 Q-loop/lid; other site 246196011782 ABC transporter signature motif; other site 246196011783 Walker B; other site 246196011784 D-loop; other site 246196011785 H-loop/switch region; other site 246196011786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196011787 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196011788 classical (c) SDRs; Region: SDR_c; cd05233 246196011789 NAD(P) binding site [chemical binding]; other site 246196011790 active site 246196011791 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 246196011792 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196011793 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196011794 Ligand Binding Site [chemical binding]; other site 246196011795 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196011796 Ligand Binding Site [chemical binding]; other site 246196011797 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196011798 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196011799 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196011800 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196011801 active site 246196011802 ATP binding site [chemical binding]; other site 246196011803 substrate binding site [chemical binding]; other site 246196011804 activation loop (A-loop); other site 246196011805 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 246196011806 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 246196011807 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 246196011808 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196011809 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196011810 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196011811 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196011812 FMN-binding pocket [chemical binding]; other site 246196011813 flavin binding motif; other site 246196011814 phosphate binding motif [ion binding]; other site 246196011815 beta-alpha-beta structure motif; other site 246196011816 NAD binding pocket [chemical binding]; other site 246196011817 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196011818 catalytic loop [active] 246196011819 iron binding site [ion binding]; other site 246196011820 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196011821 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196011822 iron-sulfur cluster [ion binding]; other site 246196011823 [2Fe-2S] cluster binding site [ion binding]; other site 246196011824 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246196011825 hydrophobic ligand binding site; other site 246196011826 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 246196011827 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 246196011828 active site 246196011829 catalytic site [active] 246196011830 Zn binding site [ion binding]; other site 246196011831 tetramer interface [polypeptide binding]; other site 246196011832 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 246196011833 oligomer interface [polypeptide binding]; other site 246196011834 putative active site [active] 246196011835 Mn binding site [ion binding]; other site 246196011836 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196011837 classical (c) SDRs; Region: SDR_c; cd05233 246196011838 NAD(P) binding site [chemical binding]; other site 246196011839 active site 246196011840 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196011841 classical (c) SDRs; Region: SDR_c; cd05233 246196011842 NAD(P) binding site [chemical binding]; other site 246196011843 active site 246196011844 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196011845 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196011846 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196011847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196011848 active site 246196011849 phosphorylation site [posttranslational modification] 246196011850 intermolecular recognition site; other site 246196011851 dimerization interface [polypeptide binding]; other site 246196011852 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196011853 DNA binding residues [nucleotide binding] 246196011854 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246196011855 catalytic triad [active] 246196011856 conserved cis-peptide bond; other site 246196011857 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 246196011858 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 246196011859 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 246196011860 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl19826 246196011861 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196011862 classical (c) SDRs; Region: SDR_c; cd05233 246196011863 NAD(P) binding site [chemical binding]; other site 246196011864 active site 246196011865 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 246196011866 MMPL family; Region: MMPL; pfam03176 246196011867 MMPL family; Region: MMPL; pfam03176 246196011868 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 246196011869 Transglycosylase; Region: Transgly; pfam00912 246196011870 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 246196011871 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196011872 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196011873 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 246196011874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196011875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011876 dimer interface [polypeptide binding]; other site 246196011877 conserved gate region; other site 246196011878 putative PBP binding loops; other site 246196011879 ABC-ATPase subunit interface; other site 246196011880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196011881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196011882 dimer interface [polypeptide binding]; other site 246196011883 conserved gate region; other site 246196011884 putative PBP binding loops; other site 246196011885 ABC-ATPase subunit interface; other site 246196011886 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196011887 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011888 Walker A/P-loop; other site 246196011889 ATP binding site [chemical binding]; other site 246196011890 Q-loop/lid; other site 246196011891 ABC transporter signature motif; other site 246196011892 Walker B; other site 246196011893 D-loop; other site 246196011894 H-loop/switch region; other site 246196011895 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 246196011896 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196011897 Walker A/P-loop; other site 246196011898 ATP binding site [chemical binding]; other site 246196011899 Q-loop/lid; other site 246196011900 ABC transporter signature motif; other site 246196011901 Walker B; other site 246196011902 D-loop; other site 246196011903 H-loop/switch region; other site 246196011904 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196011905 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 246196011906 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196011907 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196011908 active site 246196011909 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196011910 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196011911 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196011912 active site 246196011913 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196011914 tetramer interface [polypeptide binding]; other site 246196011915 active site 246196011916 Mg2+/Mn2+ binding site [ion binding]; other site 246196011917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196011918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196011919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196011920 dimerization interface [polypeptide binding]; other site 246196011921 Excalibur calcium-binding domain; Region: Excalibur; smart00894 246196011922 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246196011923 catalytic triad [active] 246196011924 conserved cis-peptide bond; other site 246196011925 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 246196011926 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196011927 DNA binding residues [nucleotide binding] 246196011928 putative dimer interface [polypeptide binding]; other site 246196011929 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196011930 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 246196011931 catalytic Zn binding site [ion binding]; other site 246196011932 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 246196011933 structural Zn binding site [ion binding]; other site 246196011934 tetramer interface [polypeptide binding]; other site 246196011935 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 246196011936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196011937 motif II; other site 246196011938 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196011939 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196011940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196011941 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196011942 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 246196011943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196011944 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196011945 DNA binding residues [nucleotide binding] 246196011946 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 246196011947 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196011948 DNL zinc finger; Region: zf-DNL; pfam05180 246196011949 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196011950 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 246196011951 FAD binding pocket [chemical binding]; other site 246196011952 FAD binding motif [chemical binding]; other site 246196011953 phosphate binding motif [ion binding]; other site 246196011954 beta-alpha-beta structure motif; other site 246196011955 NAD binding pocket [chemical binding]; other site 246196011956 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 246196011957 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 246196011958 Moco binding site; other site 246196011959 metal coordination site [ion binding]; other site 246196011960 Protein of unknown function (DUF421); Region: DUF421; pfam04239 246196011961 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 246196011962 putative active site [active] 246196011963 catalytic residue [active] 246196011964 methionine sulfoxide reductase A; Provisional; Region: PRK14054 246196011965 methionine sulfoxide reductase B; Provisional; Region: PRK00222 246196011966 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196011967 classical (c) SDRs; Region: SDR_c; cd05233 246196011968 NAD(P) binding site [chemical binding]; other site 246196011969 active site 246196011970 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 246196011971 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 246196011972 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196011973 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 246196011974 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196011975 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196011976 putative NAD(P) binding site [chemical binding]; other site 246196011977 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 246196011978 homotrimer interaction site [polypeptide binding]; other site 246196011979 putative active site [active] 246196011980 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 246196011981 FMN binding site [chemical binding]; other site 246196011982 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 246196011983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196011984 putative substrate translocation pore; other site 246196011985 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196011986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196011987 NAD(P) binding site [chemical binding]; other site 246196011988 active site 246196011989 GcpE protein; Region: GcpE; cl19500 246196011990 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 246196011991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196011992 binding surface 246196011993 TPR motif; other site 246196011994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196011995 DNA binding residues [nucleotide binding] 246196011996 dimerization interface [polypeptide binding]; other site 246196011997 Predicted ATPase [General function prediction only]; Region: COG3899 246196011998 AAA ATPase domain; Region: AAA_16; pfam13191 246196011999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196012000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196012001 DNA binding residues [nucleotide binding] 246196012002 dimerization interface [polypeptide binding]; other site 246196012003 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246196012004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196012005 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 246196012006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196012007 active site 246196012008 motif I; other site 246196012009 motif II; other site 246196012010 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 246196012011 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 246196012012 transketolase; Reviewed; Region: PRK05899 246196012013 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 246196012014 TPP-binding site [chemical binding]; other site 246196012015 dimer interface [polypeptide binding]; other site 246196012016 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246196012017 PYR/PP interface [polypeptide binding]; other site 246196012018 dimer interface [polypeptide binding]; other site 246196012019 TPP binding site [chemical binding]; other site 246196012020 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196012021 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 246196012022 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 246196012023 D-pathway; other site 246196012024 Putative ubiquinol binding site [chemical binding]; other site 246196012025 Low-spin heme (heme b) binding site [chemical binding]; other site 246196012026 Putative water exit pathway; other site 246196012027 Binuclear center (heme o3/CuB) [ion binding]; other site 246196012028 K-pathway; other site 246196012029 Putative proton exit pathway; other site 246196012030 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196012031 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196012032 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 246196012033 classical (c) SDRs; Region: SDR_c; cd05233 246196012034 NAD(P) binding site [chemical binding]; other site 246196012035 active site 246196012036 Cupin domain; Region: Cupin_2; cl17218 246196012037 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196012038 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196012039 putative NAD(P) binding site [chemical binding]; other site 246196012040 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 246196012041 PemK-like protein; Region: PemK; pfam02452 246196012042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196012043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196012044 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196012045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196012046 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196012047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196012048 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196012049 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196012050 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 246196012051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196012052 catalytic residue [active] 246196012053 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196012054 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196012055 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196012056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196012057 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246196012058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196012059 putative DNA binding site [nucleotide binding]; other site 246196012060 putative Zn2+ binding site [ion binding]; other site 246196012061 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196012062 Na binding site [ion binding]; other site 246196012063 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 246196012064 oligomer interface [polypeptide binding]; other site 246196012065 putative active site [active] 246196012066 Mn binding site [ion binding]; other site 246196012067 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 246196012068 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196012069 PYR/PP interface [polypeptide binding]; other site 246196012070 dimer interface [polypeptide binding]; other site 246196012071 TPP binding site [chemical binding]; other site 246196012072 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196012073 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 246196012074 TPP-binding site [chemical binding]; other site 246196012075 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 246196012076 Na binding site [ion binding]; other site 246196012077 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 246196012078 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 246196012079 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246196012080 Cutinase; Region: Cutinase; pfam01083 246196012081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012082 dimer interface [polypeptide binding]; other site 246196012083 conserved gate region; other site 246196012084 putative PBP binding loops; other site 246196012085 ABC-ATPase subunit interface; other site 246196012086 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196012087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012088 dimer interface [polypeptide binding]; other site 246196012089 conserved gate region; other site 246196012090 putative PBP binding loops; other site 246196012091 ABC-ATPase subunit interface; other site 246196012092 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196012093 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196012094 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 246196012095 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 246196012096 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196012097 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 246196012098 Walker A/P-loop; other site 246196012099 ATP binding site [chemical binding]; other site 246196012100 Q-loop/lid; other site 246196012101 ABC transporter signature motif; other site 246196012102 Walker B; other site 246196012103 D-loop; other site 246196012104 H-loop/switch region; other site 246196012105 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196012106 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196012107 Walker A/P-loop; other site 246196012108 ATP binding site [chemical binding]; other site 246196012109 Q-loop/lid; other site 246196012110 ABC transporter signature motif; other site 246196012111 Walker B; other site 246196012112 D-loop; other site 246196012113 H-loop/switch region; other site 246196012114 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196012115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196012116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196012117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196012118 putative substrate translocation pore; other site 246196012119 CCC1-related family of proteins; Region: CCC1_like; cl00278 246196012120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196012122 active site 246196012123 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 246196012124 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196012125 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196012126 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196012127 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 246196012128 cyclase homology domain; Region: CHD; cd07302 246196012129 nucleotidyl binding site; other site 246196012130 metal binding site [ion binding]; metal-binding site 246196012131 dimer interface [polypeptide binding]; other site 246196012132 Protein of unknown function (DUF3984); Region: DUF3984; pfam13136 246196012133 DNA primase; Validated; Region: dnaG; PRK05667 246196012134 CHC2 zinc finger; Region: zf-CHC2; pfam01807 246196012135 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 246196012136 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 246196012137 active site 246196012138 metal binding site [ion binding]; metal-binding site 246196012139 interdomain interaction site; other site 246196012140 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 246196012141 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 246196012142 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 246196012143 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196012144 Zn2+ binding site [ion binding]; other site 246196012145 Mg2+ binding site [ion binding]; other site 246196012146 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 246196012147 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 246196012148 glycyl-tRNA synthetase; Provisional; Region: PRK04173 246196012149 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 246196012150 dimer interface [polypeptide binding]; other site 246196012151 motif 1; other site 246196012152 active site 246196012153 motif 2; other site 246196012154 motif 3; other site 246196012155 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 246196012156 anticodon binding site; other site 246196012157 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196012158 dimerization interface [polypeptide binding]; other site 246196012159 putative DNA binding site [nucleotide binding]; other site 246196012160 putative Zn2+ binding site [ion binding]; other site 246196012161 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246196012162 metal binding site 2 [ion binding]; metal-binding site 246196012163 putative DNA binding helix; other site 246196012164 metal binding site 1 [ion binding]; metal-binding site 246196012165 dimer interface [polypeptide binding]; other site 246196012166 structural Zn2+ binding site [ion binding]; other site 246196012167 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 246196012168 nudix motif; other site 246196012169 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 246196012170 active site 246196012171 dimer interface [polypeptide binding]; other site 246196012172 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 246196012173 Recombination protein O N terminal; Region: RecO_N; pfam11967 246196012174 Recombination protein O C terminal; Region: RecO_C; pfam02565 246196012175 amidase; Provisional; Region: PRK06061 246196012176 GTPase Era; Reviewed; Region: era; PRK00089 246196012177 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 246196012178 G1 box; other site 246196012179 GTP/Mg2+ binding site [chemical binding]; other site 246196012180 Switch I region; other site 246196012181 G2 box; other site 246196012182 Switch II region; other site 246196012183 G3 box; other site 246196012184 G4 box; other site 246196012185 G5 box; other site 246196012186 KH domain; Region: KH_2; pfam07650 246196012187 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246196012188 Domain of unknown function DUF21; Region: DUF21; pfam01595 246196012189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246196012190 Transporter associated domain; Region: CorC_HlyC; smart01091 246196012191 metal-binding heat shock protein; Provisional; Region: PRK00016 246196012192 K homology RNA-binding domain; Region: KH; smart00322 246196012193 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 246196012194 PhoH-like protein; Region: PhoH; pfam02562 246196012195 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 246196012196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 246196012197 chaperone protein DnaJ; Provisional; Region: PRK14278 246196012198 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246196012199 HSP70 interaction site [polypeptide binding]; other site 246196012200 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 246196012201 Zn binding sites [ion binding]; other site 246196012202 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 246196012203 dimer interface [polypeptide binding]; other site 246196012204 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 246196012205 HTH domain; Region: HTH_11; cl17392 246196012206 HrcA protein C terminal domain; Region: HrcA; pfam01628 246196012207 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 246196012208 MbtH-like protein; Region: MbtH; pfam03621 246196012209 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 246196012210 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196012211 Condensation domain; Region: Condensation; pfam00668 246196012212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196012213 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196012214 acyl-activating enzyme (AAE) consensus motif; other site 246196012215 AMP binding site [chemical binding]; other site 246196012216 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196012217 Condensation domain; Region: Condensation; cl19241 246196012218 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246196012219 Condensation domain; Region: Condensation; cl19241 246196012220 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196012221 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196012222 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246196012223 acyl-activating enzyme (AAE) consensus motif; other site 246196012224 AMP binding site [chemical binding]; other site 246196012225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196012226 Condensation domain; Region: Condensation; pfam00668 246196012227 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246196012228 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196012229 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196012230 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246196012231 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196012232 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 246196012233 short chain dehydrogenase; Region: adh_short; pfam00106 246196012234 NADP binding site [chemical binding]; other site 246196012235 active site 246196012236 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196012237 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196012238 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246196012239 active site 246196012240 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 246196012241 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196012242 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 246196012243 Condensation domain; Region: Condensation; cl19241 246196012244 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246196012245 Nonribosomal peptide synthase; Region: NRPS; pfam08415 246196012246 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 246196012247 acyl-activating enzyme (AAE) consensus motif; other site 246196012248 AMP binding site [chemical binding]; other site 246196012249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196012250 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 246196012251 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 246196012252 acyl-activating enzyme (AAE) consensus motif; other site 246196012253 active site 246196012254 AMP binding site [chemical binding]; other site 246196012255 substrate binding site [chemical binding]; other site 246196012256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196012257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196012258 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 246196012259 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196012260 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012261 active site 246196012262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196012263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246196012264 Walker A/P-loop; other site 246196012265 ATP binding site [chemical binding]; other site 246196012266 Q-loop/lid; other site 246196012267 ABC transporter signature motif; other site 246196012268 Walker B; other site 246196012269 D-loop; other site 246196012270 H-loop/switch region; other site 246196012271 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246196012272 NMT1-like family; Region: NMT1_2; pfam13379 246196012273 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196012274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012275 dimer interface [polypeptide binding]; other site 246196012276 conserved gate region; other site 246196012277 putative PBP binding loops; other site 246196012278 ABC-ATPase subunit interface; other site 246196012279 Winged helix-turn helix; Region: HTH_29; pfam13551 246196012280 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196012281 putative DNA binding site [nucleotide binding]; other site 246196012282 dimerization interface [polypeptide binding]; other site 246196012283 putative Zn2+ binding site [ion binding]; other site 246196012284 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196012285 salicylate synthase MbtI; Reviewed; Region: PRK07912 246196012286 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246196012287 coproporphyrinogen III oxidase; Validated; Region: PRK05628 246196012288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196012289 FeS/SAM binding site; other site 246196012290 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 246196012291 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196012292 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 246196012293 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246196012294 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 246196012295 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 246196012296 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 246196012297 Active Sites [active] 246196012298 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 246196012299 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 246196012300 putative active site [active] 246196012301 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 246196012302 putative active site [active] 246196012303 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 246196012304 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 246196012305 Walker A/P-loop; other site 246196012306 ATP binding site [chemical binding]; other site 246196012307 Q-loop/lid; other site 246196012308 ABC transporter signature motif; other site 246196012309 Walker B; other site 246196012310 D-loop; other site 246196012311 H-loop/switch region; other site 246196012312 TOBE-like domain; Region: TOBE_3; pfam12857 246196012313 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246196012314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012315 dimer interface [polypeptide binding]; other site 246196012316 conserved gate region; other site 246196012317 putative PBP binding loops; other site 246196012318 ABC-ATPase subunit interface; other site 246196012319 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246196012320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012321 dimer interface [polypeptide binding]; other site 246196012322 conserved gate region; other site 246196012323 putative PBP binding loops; other site 246196012324 ABC-ATPase subunit interface; other site 246196012325 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246196012326 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 246196012327 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 246196012328 TQXA domain; Region: TQXA_dom; TIGR03934 246196012329 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 246196012330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196012331 catalytic residue [active] 246196012332 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196012333 active site 246196012334 dimer interface [polypeptide binding]; other site 246196012335 non-prolyl cis peptide bond; other site 246196012336 insertion regions; other site 246196012337 hypothetical protein; Provisional; Region: PRK01346 246196012338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196012339 Coenzyme A binding pocket [chemical binding]; other site 246196012340 Sterol carrier protein domain; Region: SCP2_2; pfam13530 246196012341 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196012342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196012343 Walker A/P-loop; other site 246196012344 ATP binding site [chemical binding]; other site 246196012345 Q-loop/lid; other site 246196012346 ABC transporter signature motif; other site 246196012347 Walker B; other site 246196012348 D-loop; other site 246196012349 H-loop/switch region; other site 246196012350 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196012351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196012352 Walker A/P-loop; other site 246196012353 ATP binding site [chemical binding]; other site 246196012354 Q-loop/lid; other site 246196012355 ABC transporter signature motif; other site 246196012356 Walker B; other site 246196012357 D-loop; other site 246196012358 H-loop/switch region; other site 246196012359 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196012360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196012361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012362 dimer interface [polypeptide binding]; other site 246196012363 conserved gate region; other site 246196012364 putative PBP binding loops; other site 246196012365 ABC-ATPase subunit interface; other site 246196012366 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196012367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012368 dimer interface [polypeptide binding]; other site 246196012369 conserved gate region; other site 246196012370 putative PBP binding loops; other site 246196012371 ABC-ATPase subunit interface; other site 246196012372 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196012373 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 246196012374 peptide binding site [polypeptide binding]; other site 246196012375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196012376 S-adenosylmethionine binding site [chemical binding]; other site 246196012377 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196012378 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012379 active site 246196012380 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246196012381 Amino acid permease; Region: AA_permease_2; pfam13520 246196012382 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196012383 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196012384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246196012385 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196012386 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196012387 active site 246196012388 non-prolyl cis peptide bond; other site 246196012389 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196012390 active site 246196012391 non-prolyl cis peptide bond; other site 246196012392 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196012393 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012394 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012395 GTP-binding protein LepA; Provisional; Region: PRK05433 246196012396 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 246196012397 G1 box; other site 246196012398 putative GEF interaction site [polypeptide binding]; other site 246196012399 GTP/Mg2+ binding site [chemical binding]; other site 246196012400 Switch I region; other site 246196012401 G2 box; other site 246196012402 G3 box; other site 246196012403 Switch II region; other site 246196012404 G4 box; other site 246196012405 G5 box; other site 246196012406 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 246196012407 Elongation Factor G, domain II; Region: EFG_II; pfam14492 246196012408 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 246196012409 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 246196012410 PemK-like protein; Region: PemK; pfam02452 246196012411 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196012412 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246196012413 Walker A/P-loop; other site 246196012414 ATP binding site [chemical binding]; other site 246196012415 Q-loop/lid; other site 246196012416 ABC transporter signature motif; other site 246196012417 Walker B; other site 246196012418 D-loop; other site 246196012419 H-loop/switch region; other site 246196012420 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246196012421 ABC-ATPase subunit interface; other site 246196012422 dimer interface [polypeptide binding]; other site 246196012423 putative PBP binding regions; other site 246196012424 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 246196012425 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196012426 intersubunit interface [polypeptide binding]; other site 246196012427 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 246196012428 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196012429 intersubunit interface [polypeptide binding]; other site 246196012430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196012431 FOG: CBS domain [General function prediction only]; Region: COG0517 246196012432 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 246196012433 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196012434 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196012435 active site 246196012436 catalytic tetrad [active] 246196012437 ribonuclease Z; Reviewed; Region: PRK00055 246196012438 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246196012439 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 246196012440 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246196012441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 246196012442 Uncharacterized conserved protein [Function unknown]; Region: COG2308 246196012443 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 246196012444 hypothetical protein; Reviewed; Region: PRK07914 246196012445 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 246196012446 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 246196012447 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 246196012448 Competence protein; Region: Competence; pfam03772 246196012449 comEA protein; Region: comE; TIGR01259 246196012450 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 246196012451 envelope glycoprotein C; Provisional; Region: PHA03269 246196012452 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Region: TFIIF_alpha; pfam05793 246196012453 prohibitin homologues; Region: PHB; smart00244 246196012454 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 246196012455 trimer interface [polypeptide binding]; other site 246196012456 EDD domain protein, DegV family; Region: DegV; TIGR00762 246196012457 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 246196012458 active site 246196012459 catalytic triad [active] 246196012460 oxyanion hole [active] 246196012461 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196012462 catalytic core [active] 246196012463 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 246196012464 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 246196012465 active site 246196012466 (T/H)XGH motif; other site 246196012467 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 246196012468 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 246196012469 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196012470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196012471 Walker A motif; other site 246196012472 ATP binding site [chemical binding]; other site 246196012473 Walker B motif; other site 246196012474 arginine finger; other site 246196012475 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 246196012476 putative catalytic cysteine [active] 246196012477 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 246196012478 substrate binding site [chemical binding]; other site 246196012479 dimer interface [polypeptide binding]; other site 246196012480 ATP binding site [chemical binding]; other site 246196012481 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196012482 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196012483 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196012484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196012485 Walker A/P-loop; other site 246196012486 ATP binding site [chemical binding]; other site 246196012487 Q-loop/lid; other site 246196012488 ABC transporter signature motif; other site 246196012489 Walker B; other site 246196012490 D-loop; other site 246196012491 H-loop/switch region; other site 246196012492 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196012493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012494 dimer interface [polypeptide binding]; other site 246196012495 conserved gate region; other site 246196012496 putative PBP binding loops; other site 246196012497 ABC-ATPase subunit interface; other site 246196012498 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196012499 active site residue [active] 246196012500 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196012501 active site residue [active] 246196012502 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196012503 active site residue [active] 246196012504 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196012505 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196012506 active site 246196012507 non-prolyl cis peptide bond; other site 246196012508 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012509 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196012510 active site 246196012511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012512 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012513 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012514 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012515 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196012516 Cupin domain; Region: Cupin_2; cl17218 246196012517 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 246196012518 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196012519 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196012520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196012521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196012522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196012523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196012524 dimerization interface [polypeptide binding]; other site 246196012525 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196012526 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 246196012527 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246196012528 transmembrane helices; other site 246196012529 Histidine kinase; Region: HisKA_3; pfam07730 246196012530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196012531 ATP binding site [chemical binding]; other site 246196012532 Mg2+ binding site [ion binding]; other site 246196012533 G-X-G motif; other site 246196012534 NAD synthetase; Reviewed; Region: nadE; PRK02628 246196012535 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 246196012536 multimer interface [polypeptide binding]; other site 246196012537 active site 246196012538 catalytic triad [active] 246196012539 protein interface 1 [polypeptide binding]; other site 246196012540 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 246196012541 homodimer interface [polypeptide binding]; other site 246196012542 NAD binding pocket [chemical binding]; other site 246196012543 ATP binding pocket [chemical binding]; other site 246196012544 Mg binding site [ion binding]; other site 246196012545 active-site loop [active] 246196012546 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246196012547 catalytic triad [active] 246196012548 conserved cis-peptide bond; other site 246196012549 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 246196012550 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196012551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196012552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196012553 gamma-glutamyl kinase; Provisional; Region: PRK05429 246196012554 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 246196012555 nucleotide binding site [chemical binding]; other site 246196012556 homotetrameric interface [polypeptide binding]; other site 246196012557 putative phosphate binding site [ion binding]; other site 246196012558 putative allosteric binding site; other site 246196012559 PUA domain; Region: PUA; pfam01472 246196012560 GTPase CgtA; Reviewed; Region: obgE; PRK12296 246196012561 GTP1/OBG; Region: GTP1_OBG; pfam01018 246196012562 Obg GTPase; Region: Obg; cd01898 246196012563 G1 box; other site 246196012564 GTP/Mg2+ binding site [chemical binding]; other site 246196012565 Switch I region; other site 246196012566 G2 box; other site 246196012567 G3 box; other site 246196012568 Switch II region; other site 246196012569 G4 box; other site 246196012570 G5 box; other site 246196012571 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 246196012572 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 246196012573 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 246196012574 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246196012575 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 246196012576 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 246196012577 homodimer interface [polypeptide binding]; other site 246196012578 oligonucleotide binding site [chemical binding]; other site 246196012579 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 246196012580 Nucleoside diphosphate kinase; Region: NDK; pfam00334 246196012581 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 246196012582 active site 246196012583 multimer interface [polypeptide binding]; other site 246196012584 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 246196012585 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 246196012586 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 246196012587 active site 246196012588 HIGH motif; other site 246196012589 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246196012590 KMSKS motif; other site 246196012591 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 246196012592 tRNA binding surface [nucleotide binding]; other site 246196012593 anticodon binding site; other site 246196012594 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 246196012595 Uncharacterized conserved protein [Function unknown]; Region: COG3268 246196012596 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 246196012597 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196012598 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 246196012599 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 246196012600 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246196012601 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246196012602 FMN-binding pocket [chemical binding]; other site 246196012603 flavin binding motif; other site 246196012604 phosphate binding motif [ion binding]; other site 246196012605 beta-alpha-beta structure motif; other site 246196012606 NAD binding pocket [chemical binding]; other site 246196012607 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196012608 catalytic loop [active] 246196012609 iron binding site [ion binding]; other site 246196012610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196012611 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 246196012612 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 246196012613 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 246196012614 GTP binding site; other site 246196012615 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 246196012616 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 246196012617 TPP-binding site [chemical binding]; other site 246196012618 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 246196012619 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 246196012620 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246196012621 dimer interface [polypeptide binding]; other site 246196012622 PYR/PP interface [polypeptide binding]; other site 246196012623 TPP binding site [chemical binding]; other site 246196012624 substrate binding site [chemical binding]; other site 246196012625 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246196012626 substrate binding site [chemical binding]; other site 246196012627 ATP binding site [chemical binding]; other site 246196012628 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196012629 DNA binding site [nucleotide binding] 246196012630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196012631 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 246196012632 putative ligand binding site [chemical binding]; other site 246196012633 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 246196012634 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196012635 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196012636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246196012637 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196012638 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196012639 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196012640 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196012641 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246196012642 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 246196012643 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 246196012644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196012645 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196012646 active site 246196012647 catalytic tetrad [active] 246196012648 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 246196012649 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246196012650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196012651 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196012652 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196012653 Walker A/P-loop; other site 246196012654 ATP binding site [chemical binding]; other site 246196012655 Q-loop/lid; other site 246196012656 ABC transporter signature motif; other site 246196012657 Walker B; other site 246196012658 D-loop; other site 246196012659 H-loop/switch region; other site 246196012660 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196012661 TM-ABC transporter signature motif; other site 246196012662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196012663 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 246196012664 putative ligand binding site [chemical binding]; other site 246196012665 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196012666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196012667 DNA-binding site [nucleotide binding]; DNA binding site 246196012668 UTRA domain; Region: UTRA; pfam07702 246196012669 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 246196012670 substrate binding site [chemical binding]; other site 246196012671 ATP binding site [chemical binding]; other site 246196012672 KduI/IolB family; Region: KduI; pfam04962 246196012673 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 246196012674 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196012675 PYR/PP interface [polypeptide binding]; other site 246196012676 dimer interface [polypeptide binding]; other site 246196012677 TPP binding site [chemical binding]; other site 246196012678 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196012679 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 246196012680 TPP-binding site; other site 246196012681 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196012682 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196012683 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196012684 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196012685 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246196012686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196012687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196012688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196012689 dimerization interface [polypeptide binding]; other site 246196012690 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 246196012691 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 246196012692 putative molybdopterin cofactor binding site [chemical binding]; other site 246196012693 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 246196012694 putative molybdopterin cofactor binding site; other site 246196012695 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 246196012696 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196012697 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196012698 active site 246196012699 TDP-binding site; other site 246196012700 acceptor substrate-binding pocket; other site 246196012701 homodimer interface [polypeptide binding]; other site 246196012702 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 246196012703 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 246196012704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196012705 Walker A motif; other site 246196012706 ATP binding site [chemical binding]; other site 246196012707 Walker B motif; other site 246196012708 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246196012709 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 246196012710 oligomer interface [polypeptide binding]; other site 246196012711 active site residues [active] 246196012712 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 246196012713 oligomer interface [polypeptide binding]; other site 246196012714 active site residues [active] 246196012715 trigger factor; Provisional; Region: tig; PRK01490 246196012716 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 246196012717 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246196012718 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 246196012719 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196012720 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196012721 GA module; Region: GA; pfam01468 246196012722 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 246196012723 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 246196012724 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 246196012725 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 246196012726 putative DNA binding site [nucleotide binding]; other site 246196012727 catalytic residue [active] 246196012728 putative H2TH interface [polypeptide binding]; other site 246196012729 putative catalytic residues [active] 246196012730 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246196012731 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246196012732 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 246196012733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196012734 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196012735 active site 246196012736 catalytic tetrad [active] 246196012737 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246196012738 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246196012739 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246196012740 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246196012741 nucleoside/Zn binding site; other site 246196012742 dimer interface [polypeptide binding]; other site 246196012743 catalytic motif [active] 246196012744 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246196012745 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196012746 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 246196012747 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 246196012748 Zn binding site [ion binding]; other site 246196012749 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 246196012750 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196012751 active site 246196012752 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196012753 active site 246196012754 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 246196012755 apolar tunnel; other site 246196012756 heme binding site [chemical binding]; other site 246196012757 dimerization interface [polypeptide binding]; other site 246196012758 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 246196012759 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 246196012760 active site 246196012761 catalytic site [active] 246196012762 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246196012763 active site 246196012764 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 246196012765 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 246196012766 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 246196012767 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196012768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196012769 Walker A/P-loop; other site 246196012770 ATP binding site [chemical binding]; other site 246196012771 Q-loop/lid; other site 246196012772 ABC transporter signature motif; other site 246196012773 ABC transporter; Region: ABC_tran_2; pfam12848 246196012774 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196012775 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 246196012776 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 246196012777 dimer interface [polypeptide binding]; other site 246196012778 ssDNA binding site [nucleotide binding]; other site 246196012779 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246196012780 Copper resistance protein D; Region: CopD; cl00563 246196012781 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 246196012782 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 246196012783 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 246196012784 putative acyl-acceptor binding pocket; other site 246196012785 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 246196012786 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 246196012787 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196012788 putative acyl-acceptor binding pocket; other site 246196012789 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196012790 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196012791 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196012792 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196012793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196012794 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246196012795 S-adenosylmethionine binding site [chemical binding]; other site 246196012796 enoyl-CoA hydratase; Provisional; Region: PRK05870 246196012797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196012798 substrate binding site [chemical binding]; other site 246196012799 oxyanion hole (OAH) forming residues; other site 246196012800 trimer interface [polypeptide binding]; other site 246196012801 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 246196012802 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246196012803 E3 interaction surface; other site 246196012804 lipoyl attachment site [posttranslational modification]; other site 246196012805 e3 binding domain; Region: E3_binding; pfam02817 246196012806 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246196012807 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 246196012808 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 246196012809 alpha subunit interface [polypeptide binding]; other site 246196012810 TPP binding site [chemical binding]; other site 246196012811 heterodimer interface [polypeptide binding]; other site 246196012812 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246196012813 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 246196012814 tetramer interface [polypeptide binding]; other site 246196012815 TPP-binding site [chemical binding]; other site 246196012816 heterodimer interface [polypeptide binding]; other site 246196012817 phosphorylation loop region [posttranslational modification] 246196012818 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196012819 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 246196012820 putative active site [active] 246196012821 putative catalytic site [active] 246196012822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196012823 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196012824 active site 246196012825 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 246196012826 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196012827 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 246196012828 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 246196012829 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196012830 carboxyltransferase (CT) interaction site; other site 246196012831 biotinylation site [posttranslational modification]; other site 246196012832 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 246196012833 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196012834 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196012835 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196012836 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 246196012837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196012838 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196012839 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196012840 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 246196012841 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 246196012842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196012843 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196012844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196012845 NAD(P) binding site [chemical binding]; other site 246196012846 active site 246196012847 Domain of unknown function DUF87; Region: DUF87; cl19135 246196012848 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 246196012849 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 246196012850 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 246196012851 catalytic site [active] 246196012852 putative active site [active] 246196012853 putative substrate binding site [chemical binding]; other site 246196012854 dimer interface [polypeptide binding]; other site 246196012855 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246196012856 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196012857 active site 246196012858 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 246196012859 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 246196012860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196012861 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 246196012862 Enoylreductase; Region: PKS_ER; smart00829 246196012863 NAD(P) binding site [chemical binding]; other site 246196012864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196012865 short chain dehydrogenase; Region: adh_short; pfam00106 246196012866 NAD(P) binding site [chemical binding]; other site 246196012867 active site 246196012868 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196012869 Condensation domain; Region: Condensation; cl19241 246196012870 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196012871 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196012872 acyl-CoA synthetase; Validated; Region: PRK05850 246196012873 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196012874 acyl-activating enzyme (AAE) consensus motif; other site 246196012875 active site 246196012876 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246196012877 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246196012878 active site 246196012879 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 246196012880 PE-PPE domain; Region: PE-PPE; pfam08237 246196012881 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246196012882 active site 246196012883 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 246196012884 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 246196012885 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196012886 Methyltransferase domain; Region: Methyltransf_24; pfam13578 246196012887 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246196012888 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246196012889 homodimer interface [polypeptide binding]; other site 246196012890 active site 246196012891 TDP-binding site; other site 246196012892 acceptor substrate-binding pocket; other site 246196012893 Transport protein; Region: actII; TIGR00833 246196012894 MMPL family; Region: MMPL; pfam03176 246196012895 Conserved oligomeric complex COG6; Region: COG6; cl19764 246196012896 MMPL family; Region: MMPL; pfam03176 246196012897 classical (c) SDRs; Region: SDR_c; cd05233 246196012898 short chain dehydrogenase; Region: adh_short; pfam00106 246196012899 NAD(P) binding site [chemical binding]; other site 246196012900 active site 246196012901 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 246196012902 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 246196012903 putative hydrophobic ligand binding site [chemical binding]; other site 246196012904 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 246196012905 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 246196012906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246196012907 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246196012908 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 246196012909 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246196012910 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 246196012911 catalytic triad [active] 246196012912 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 246196012913 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246196012914 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246196012915 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 246196012916 hypothetical protein; Provisional; Region: PRK08201 246196012917 active site 246196012918 metal binding site [ion binding]; metal-binding site 246196012919 dimer interface [polypeptide binding]; other site 246196012920 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 246196012921 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246196012922 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 246196012923 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246196012924 phosphate binding site [ion binding]; other site 246196012925 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 246196012926 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 246196012927 putative active site [active] 246196012928 putative catalytic site [active] 246196012929 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246196012930 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 246196012931 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 246196012932 putative NAD(P) binding site [chemical binding]; other site 246196012933 active site 246196012934 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 246196012935 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246196012936 active site 246196012937 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196012938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196012939 Walker A/P-loop; other site 246196012940 ATP binding site [chemical binding]; other site 246196012941 Q-loop/lid; other site 246196012942 ABC transporter signature motif; other site 246196012943 Walker B; other site 246196012944 D-loop; other site 246196012945 H-loop/switch region; other site 246196012946 TOBE domain; Region: TOBE_2; pfam08402 246196012947 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 246196012948 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196012949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012950 dimer interface [polypeptide binding]; other site 246196012951 conserved gate region; other site 246196012952 putative PBP binding loops; other site 246196012953 ABC-ATPase subunit interface; other site 246196012954 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196012955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196012956 dimer interface [polypeptide binding]; other site 246196012957 conserved gate region; other site 246196012958 putative PBP binding loops; other site 246196012959 ABC-ATPase subunit interface; other site 246196012960 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246196012961 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196012962 DNA binding residues [nucleotide binding] 246196012963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196012964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196012965 putative substrate translocation pore; other site 246196012966 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 246196012967 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 246196012968 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 246196012969 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196012970 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 246196012971 acyl-activating enzyme (AAE) consensus motif; other site 246196012972 acyl-activating enzyme (AAE) consensus motif; other site 246196012973 putative AMP binding site [chemical binding]; other site 246196012974 putative active site [active] 246196012975 putative CoA binding site [chemical binding]; other site 246196012976 CoA binding site [chemical binding]; other site 246196012977 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196012978 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196012979 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196012980 acyl-activating enzyme (AAE) consensus motif; other site 246196012981 AMP binding site [chemical binding]; other site 246196012982 active site 246196012983 CoA binding site [chemical binding]; other site 246196012984 enoyl-CoA hydratase; Provisional; Region: PRK06688 246196012985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196012986 substrate binding site [chemical binding]; other site 246196012987 oxyanion hole (OAH) forming residues; other site 246196012988 trimer interface [polypeptide binding]; other site 246196012989 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 246196012990 dimer interface [polypeptide binding]; other site 246196012991 substrate binding site [chemical binding]; other site 246196012992 metal binding site [ion binding]; metal-binding site 246196012993 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 246196012994 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196012995 lipid-transfer protein; Provisional; Region: PRK06059 246196012996 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196012997 active site 246196012998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196012999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013000 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013001 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013002 mce related protein; Region: MCE; pfam02470 246196013003 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013004 mce related protein; Region: MCE; pfam02470 246196013005 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196013006 mce related protein; Region: MCE; pfam02470 246196013007 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013008 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196013009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196013010 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196013011 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196013012 mce related protein; Region: MCE; pfam02470 246196013013 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013014 mce related protein; Region: MCE; pfam02470 246196013015 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196013016 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196013017 mce related protein; Region: MCE; pfam02470 246196013018 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196013019 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196013020 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196013021 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013022 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196013023 NAD binding site [chemical binding]; other site 246196013024 catalytic residues [active] 246196013025 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196013026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013027 NAD(P) binding site [chemical binding]; other site 246196013028 active site 246196013029 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196013030 classical (c) SDRs; Region: SDR_c; cd05233 246196013031 NAD(P) binding site [chemical binding]; other site 246196013032 active site 246196013033 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196013034 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013035 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013036 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013037 active site 246196013038 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 246196013039 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 246196013040 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196013041 active site 246196013042 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196013043 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196013044 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 246196013045 iron-sulfur cluster [ion binding]; other site 246196013046 [2Fe-2S] cluster binding site [ion binding]; other site 246196013047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013048 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 246196013049 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 246196013050 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 246196013051 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196013052 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 246196013053 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196013054 thiolase; Provisional; Region: PRK06158 246196013055 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196013056 active site 246196013057 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196013058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013059 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196013060 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196013061 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196013062 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196013063 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196013064 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196013065 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013066 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196013067 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196013068 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 246196013069 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246196013070 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013071 Emopamil binding protein; Region: EBP; pfam05241 246196013072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013074 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013075 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013076 active site 246196013077 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196013078 Phosphotransferase enzyme family; Region: APH; pfam01636 246196013079 putative active site [active] 246196013080 putative substrate binding site [chemical binding]; other site 246196013081 ATP binding site [chemical binding]; other site 246196013082 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196013083 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 246196013084 NAD(P) binding site [chemical binding]; other site 246196013085 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013090 active site 246196013091 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 246196013092 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196013093 dimer interface [polypeptide binding]; other site 246196013094 active site 246196013095 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013096 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196013097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013098 NAD(P) binding site [chemical binding]; other site 246196013099 active site 246196013100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013102 active site 246196013103 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196013104 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196013105 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196013106 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196013107 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196013108 [2Fe-2S] cluster binding site [ion binding]; other site 246196013109 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 246196013110 alpha subunit interface [polypeptide binding]; other site 246196013111 active site 246196013112 substrate binding site [chemical binding]; other site 246196013113 Fe binding site [ion binding]; other site 246196013114 Herpesvirus VP23 like capsid protein; Region: Herpes_V23; pfam01802 246196013115 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196013116 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 246196013117 active site 246196013118 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196013119 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 246196013120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013121 active site 246196013122 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013124 enoyl-CoA hydratase; Provisional; Region: PRK08290 246196013125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196013126 substrate binding site [chemical binding]; other site 246196013127 oxyanion hole (OAH) forming residues; other site 246196013128 trimer interface [polypeptide binding]; other site 246196013129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013131 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 246196013132 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196013133 classical (c) SDRs; Region: SDR_c; cd05233 246196013134 NAD(P) binding site [chemical binding]; other site 246196013135 active site 246196013136 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196013137 classical (c) SDRs; Region: SDR_c; cd05233 246196013138 NAD(P) binding site [chemical binding]; other site 246196013139 active site 246196013140 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013141 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013142 enoyl-CoA hydratase; Provisional; Region: PRK12478 246196013143 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196013144 substrate binding site [chemical binding]; other site 246196013145 oxyanion hole (OAH) forming residues; other site 246196013146 trimer interface [polypeptide binding]; other site 246196013147 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196013148 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196013149 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246196013150 active site 246196013151 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246196013152 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246196013153 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246196013154 active site 246196013155 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196013156 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013157 Divergent 4Fe-4S mono-cluster; Region: Fer4_19; cl01443 246196013158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013159 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196013160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013161 NAD(P) binding site [chemical binding]; other site 246196013162 active site 246196013163 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013164 TAP-like protein; Region: Abhydrolase_4; pfam08386 246196013165 Putative cyclase; Region: Cyclase; pfam04199 246196013166 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196013167 NAD(P) binding site [chemical binding]; other site 246196013168 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 246196013169 active site 246196013170 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 246196013171 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 246196013172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196013173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196013174 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 246196013175 active site 246196013176 metal binding site [ion binding]; metal-binding site 246196013177 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 246196013178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196013179 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196013180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013181 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 246196013182 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196013183 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 246196013184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196013185 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 246196013186 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 246196013187 Walker A; other site 246196013188 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246196013189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013190 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 246196013191 NAD(P) binding site [chemical binding]; other site 246196013192 active site 246196013193 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196013194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013195 NAD(P) binding site [chemical binding]; other site 246196013196 active site 246196013197 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196013198 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196013199 substrate binding site [chemical binding]; other site 246196013200 oxyanion hole (OAH) forming residues; other site 246196013201 trimer interface [polypeptide binding]; other site 246196013202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013203 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013204 active site 246196013205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196013207 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246196013208 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196013209 acyl-activating enzyme (AAE) consensus motif; other site 246196013210 AMP binding site [chemical binding]; other site 246196013211 active site 246196013212 CoA binding site [chemical binding]; other site 246196013213 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196013214 catalytic loop [active] 246196013215 iron binding site [ion binding]; other site 246196013216 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196013217 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 246196013218 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246196013219 B12 binding site [chemical binding]; other site 246196013220 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 246196013221 short chain dehydrogenase; Provisional; Region: PRK08278 246196013222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013223 NAD(P) binding site [chemical binding]; other site 246196013224 active site 246196013225 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196013226 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196013227 acyl-activating enzyme (AAE) consensus motif; other site 246196013228 AMP binding site [chemical binding]; other site 246196013229 active site 246196013230 CoA binding site [chemical binding]; other site 246196013231 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196013232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013233 putative substrate translocation pore; other site 246196013234 Ecdysteroid kinase; Region: EcKinase; cl17738 246196013235 Phosphotransferase enzyme family; Region: APH; pfam01636 246196013236 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013237 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196013238 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196013239 DNA binding site [nucleotide binding] 246196013240 domain linker motif; other site 246196013241 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196013242 dimerization interface [polypeptide binding]; other site 246196013243 ligand binding site [chemical binding]; other site 246196013244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013245 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196013246 putative substrate translocation pore; other site 246196013247 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 246196013248 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196013249 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246196013250 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 246196013251 dimer interface [polypeptide binding]; other site 246196013252 decamer (pentamer of dimers) interface [polypeptide binding]; other site 246196013253 catalytic triad [active] 246196013254 peroxidatic and resolving cysteines [active] 246196013255 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 246196013256 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 246196013257 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 246196013258 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196013259 acyl-activating enzyme (AAE) consensus motif; other site 246196013260 active site 246196013261 Glucitol operon activator protein (GutM); Region: GutM; cl01890 246196013262 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 246196013263 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 246196013264 active site 246196013265 dimerization interface [polypeptide binding]; other site 246196013266 ribonuclease PH; Reviewed; Region: rph; PRK00173 246196013267 Ribonuclease PH; Region: RNase_PH_bact; cd11362 246196013268 hexamer interface [polypeptide binding]; other site 246196013269 active site 246196013270 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 246196013271 glutamate racemase; Provisional; Region: PRK00865 246196013272 Rhomboid family; Region: Rhomboid; pfam01694 246196013273 cysteine synthase; Region: PLN02565 246196013274 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246196013275 dimer interface [polypeptide binding]; other site 246196013276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196013277 catalytic residue [active] 246196013278 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 246196013279 MoaE interaction surface [polypeptide binding]; other site 246196013280 MoeB interaction surface [polypeptide binding]; other site 246196013281 thiocarboxylated glycine; other site 246196013282 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 246196013283 MPN+ (JAMM) motif; other site 246196013284 Zinc-binding site [ion binding]; other site 246196013285 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 246196013286 putative active site pocket [active] 246196013287 cleavage site 246196013288 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 246196013289 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 246196013290 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 246196013291 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 246196013292 active site 246196013293 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 246196013294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246196013295 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 246196013296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196013297 putative Mg++ binding site [ion binding]; other site 246196013298 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 246196013299 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 246196013300 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 246196013301 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 246196013302 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 246196013303 putative homodimer interface [polypeptide binding]; other site 246196013304 putative active site pocket [active] 246196013305 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 246196013306 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 246196013307 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 246196013308 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 246196013309 active site 246196013310 homodimer interface [polypeptide binding]; other site 246196013311 catalytic site [active] 246196013312 acceptor binding site [chemical binding]; other site 246196013313 glycogen branching enzyme; Provisional; Region: PRK05402 246196013314 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 246196013315 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 246196013316 active site 246196013317 catalytic site [active] 246196013318 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 246196013319 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 246196013320 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 246196013321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196013322 binding surface 246196013323 TPR motif; other site 246196013324 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 246196013325 putative acyltransferase; Provisional; Region: PRK05790 246196013326 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196013327 dimer interface [polypeptide binding]; other site 246196013328 active site 246196013329 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 246196013330 dimer interface [polypeptide binding]; other site 246196013331 substrate binding site [chemical binding]; other site 246196013332 metal binding site [ion binding]; metal-binding site 246196013333 hypothetical protein; Provisional; Region: PRK03298 246196013334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196013335 dimerization interface [polypeptide binding]; other site 246196013336 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196013337 cyclase homology domain; Region: CHD; cd07302 246196013338 nucleotidyl binding site; other site 246196013339 metal binding site [ion binding]; metal-binding site 246196013340 dimer interface [polypeptide binding]; other site 246196013341 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 246196013342 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 246196013343 AlkA N-terminal domain; Region: AlkA_N; smart01009 246196013344 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 246196013345 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246196013346 minor groove reading motif; other site 246196013347 helix-hairpin-helix signature motif; other site 246196013348 substrate binding pocket [chemical binding]; other site 246196013349 active site 246196013350 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196013351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196013352 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196013353 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196013354 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 246196013355 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 246196013356 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246196013357 DNA binding site [nucleotide binding] 246196013358 active site 246196013359 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 246196013360 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 246196013361 hinge; other site 246196013362 active site 246196013363 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 246196013364 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 246196013365 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 246196013366 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 246196013367 gamma subunit interface [polypeptide binding]; other site 246196013368 epsilon subunit interface [polypeptide binding]; other site 246196013369 LBP interface [polypeptide binding]; other site 246196013370 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 246196013371 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246196013372 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 246196013373 alpha subunit interaction interface [polypeptide binding]; other site 246196013374 Walker A motif; other site 246196013375 ATP binding site [chemical binding]; other site 246196013376 Walker B motif; other site 246196013377 inhibitor binding site; inhibition site 246196013378 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 246196013379 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 246196013380 core domain interface [polypeptide binding]; other site 246196013381 delta subunit interface [polypeptide binding]; other site 246196013382 epsilon subunit interface [polypeptide binding]; other site 246196013383 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 246196013384 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246196013385 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 246196013386 beta subunit interaction interface [polypeptide binding]; other site 246196013387 Walker A motif; other site 246196013388 ATP binding site [chemical binding]; other site 246196013389 Walker B motif; other site 246196013390 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 246196013391 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 246196013392 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 246196013393 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 246196013394 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 246196013395 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 246196013396 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 246196013397 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 246196013398 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196013399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196013400 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196013401 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196013402 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 246196013403 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 246196013404 Mg++ binding site [ion binding]; other site 246196013405 putative catalytic motif [active] 246196013406 substrate binding site [chemical binding]; other site 246196013407 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 246196013408 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 246196013409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196013410 S-adenosylmethionine binding site [chemical binding]; other site 246196013411 peptide chain release factor 1; Validated; Region: prfA; PRK00591 246196013412 PCRF domain; Region: PCRF; pfam03462 246196013413 RF-1 domain; Region: RF-1; pfam00472 246196013414 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 246196013415 acyl-CoA synthetase; Provisional; Region: PRK13388 246196013416 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196013417 acyl-activating enzyme (AAE) consensus motif; other site 246196013418 AMP binding site [chemical binding]; other site 246196013419 active site 246196013420 CoA binding site [chemical binding]; other site 246196013421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013423 transcription termination factor Rho; Provisional; Region: PRK12678 246196013424 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 246196013425 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246196013426 RNA binding site [nucleotide binding]; other site 246196013427 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 246196013428 multimer interface [polypeptide binding]; other site 246196013429 Walker A motif; other site 246196013430 ATP binding site [chemical binding]; other site 246196013431 Walker B motif; other site 246196013432 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 246196013433 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 246196013434 homodimer interface [polypeptide binding]; other site 246196013435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196013436 catalytic residue [active] 246196013437 homoserine dehydrogenase; Provisional; Region: PRK06349 246196013438 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 246196013439 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 246196013440 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 246196013441 diaminopimelate decarboxylase; Region: lysA; TIGR01048 246196013442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 246196013443 active site 246196013444 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196013445 substrate binding site [chemical binding]; other site 246196013446 catalytic residues [active] 246196013447 dimer interface [polypeptide binding]; other site 246196013448 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 246196013449 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 246196013450 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 246196013451 active site 246196013452 HIGH motif; other site 246196013453 KMSK motif region; other site 246196013454 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 246196013455 tRNA binding surface [nucleotide binding]; other site 246196013456 anticodon binding site; other site 246196013457 Condensation domain; Region: Condensation; cl19241 246196013458 hypothetical protein; Provisional; Region: PRK06185 246196013459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196013460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013462 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 246196013463 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196013464 Putative sensor; Region: Sensor; pfam13796 246196013465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196013466 Histidine kinase; Region: HisKA_3; pfam07730 246196013467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196013468 ATP binding site [chemical binding]; other site 246196013469 Mg2+ binding site [ion binding]; other site 246196013470 G-X-G motif; other site 246196013471 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196013472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196013473 active site 246196013474 phosphorylation site [posttranslational modification] 246196013475 intermolecular recognition site; other site 246196013476 dimerization interface [polypeptide binding]; other site 246196013477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196013478 DNA binding residues [nucleotide binding] 246196013479 dimerization interface [polypeptide binding]; other site 246196013480 Nitronate monooxygenase; Region: NMO; pfam03060 246196013481 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196013482 FMN binding site [chemical binding]; other site 246196013483 substrate binding site [chemical binding]; other site 246196013484 putative catalytic residue [active] 246196013485 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196013486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196013487 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 246196013488 metal binding site [ion binding]; metal-binding site 246196013489 Predicted transcriptional regulator [Transcription]; Region: COG1959 246196013490 Rrf2 family protein; Region: rrf2_super; TIGR00738 246196013491 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 246196013492 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 246196013493 catalytic triad [active] 246196013494 conserved cis-peptide bond; other site 246196013495 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 246196013496 active site 246196013497 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 246196013498 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 246196013499 CysD dimerization site [polypeptide binding]; other site 246196013500 G1 box; other site 246196013501 putative GEF interaction site [polypeptide binding]; other site 246196013502 GTP/Mg2+ binding site [chemical binding]; other site 246196013503 Switch I region; other site 246196013504 G2 box; other site 246196013505 G3 box; other site 246196013506 Switch II region; other site 246196013507 G4 box; other site 246196013508 G5 box; other site 246196013509 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 246196013510 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 246196013511 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 246196013512 ligand-binding site [chemical binding]; other site 246196013513 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 246196013514 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 246196013515 Active Sites [active] 246196013516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013517 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196013518 putative substrate translocation pore; other site 246196013519 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196013520 Phosphotransferase enzyme family; Region: APH; pfam01636 246196013521 putative active site [active] 246196013522 putative substrate binding site [chemical binding]; other site 246196013523 ATP binding site [chemical binding]; other site 246196013524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013526 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196013527 CoenzymeA binding site [chemical binding]; other site 246196013528 subunit interaction site [polypeptide binding]; other site 246196013529 PHB binding site; other site 246196013530 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 246196013531 active site clefts [active] 246196013532 zinc binding site [ion binding]; other site 246196013533 dimer interface [polypeptide binding]; other site 246196013534 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 246196013535 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246196013536 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 246196013537 Ligand binding site; other site 246196013538 Ligand binding site; other site 246196013539 Ligand binding site; other site 246196013540 Putative Catalytic site; other site 246196013541 DXD motif; other site 246196013542 GtrA-like protein; Region: GtrA; pfam04138 246196013543 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 246196013544 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 246196013545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196013546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196013547 dimerization interface [polypeptide binding]; other site 246196013548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196013549 dimer interface [polypeptide binding]; other site 246196013550 phosphorylation site [posttranslational modification] 246196013551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196013552 ATP binding site [chemical binding]; other site 246196013553 Mg2+ binding site [ion binding]; other site 246196013554 G-X-G motif; other site 246196013555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196013556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196013557 active site 246196013558 phosphorylation site [posttranslational modification] 246196013559 intermolecular recognition site; other site 246196013560 dimerization interface [polypeptide binding]; other site 246196013561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196013562 DNA binding site [nucleotide binding] 246196013563 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196013564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013565 dimer interface [polypeptide binding]; other site 246196013566 conserved gate region; other site 246196013567 putative PBP binding loops; other site 246196013568 ABC-ATPase subunit interface; other site 246196013569 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196013570 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 246196013571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013572 dimer interface [polypeptide binding]; other site 246196013573 conserved gate region; other site 246196013574 putative PBP binding loops; other site 246196013575 ABC-ATPase subunit interface; other site 246196013576 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 246196013577 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196013578 Walker A/P-loop; other site 246196013579 ATP binding site [chemical binding]; other site 246196013580 Q-loop/lid; other site 246196013581 ABC transporter signature motif; other site 246196013582 Walker B; other site 246196013583 D-loop; other site 246196013584 H-loop/switch region; other site 246196013585 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196013586 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196013587 Walker A/P-loop; other site 246196013588 ATP binding site [chemical binding]; other site 246196013589 Q-loop/lid; other site 246196013590 ABC transporter signature motif; other site 246196013591 Walker B; other site 246196013592 D-loop; other site 246196013593 H-loop/switch region; other site 246196013594 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 246196013595 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196013596 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 246196013597 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196013598 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013599 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 246196013600 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196013601 active site 246196013602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196013603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196013604 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 246196013605 putative substrate binding pocket [chemical binding]; other site 246196013606 putative dimerization interface [polypeptide binding]; other site 246196013607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196013608 S-adenosylmethionine binding site [chemical binding]; other site 246196013609 AAA domain; Region: AAA_23; pfam13476 246196013610 Walker A/P-loop; other site 246196013611 ATP binding site [chemical binding]; other site 246196013612 AAA domain; Region: AAA_27; pfam13514 246196013613 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 246196013614 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 246196013615 active site 246196013616 metal binding site [ion binding]; metal-binding site 246196013617 DNA binding site [nucleotide binding] 246196013618 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196013619 catalytic core [active] 246196013620 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196013621 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 246196013622 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196013623 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196013624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196013625 Walker A/P-loop; other site 246196013626 ATP binding site [chemical binding]; other site 246196013627 Q-loop/lid; other site 246196013628 ABC transporter signature motif; other site 246196013629 Walker B; other site 246196013630 D-loop; other site 246196013631 H-loop/switch region; other site 246196013632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196013633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196013634 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 246196013635 Walker A/P-loop; other site 246196013636 ATP binding site [chemical binding]; other site 246196013637 Q-loop/lid; other site 246196013638 ABC transporter signature motif; other site 246196013639 Walker B; other site 246196013640 D-loop; other site 246196013641 H-loop/switch region; other site 246196013642 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 246196013643 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 246196013644 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246196013645 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246196013646 metal-binding site [ion binding] 246196013647 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196013648 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 246196013649 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246196013650 metal-binding site [ion binding] 246196013651 Domain of unknown function (DUF305); Region: DUF305; pfam03713 246196013652 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196013653 cyclase homology domain; Region: CHD; cd07302 246196013654 nucleotidyl binding site; other site 246196013655 metal binding site [ion binding]; metal-binding site 246196013656 dimer interface [polypeptide binding]; other site 246196013657 GAF domain; Region: GAF; pfam01590 246196013658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013659 acetoin reductases; Region: 23BDH; TIGR02415 246196013660 NAD(P) binding site [chemical binding]; other site 246196013661 active site 246196013662 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196013663 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 246196013664 putative NAD(P) binding site [chemical binding]; other site 246196013665 catalytic Zn binding site [ion binding]; other site 246196013666 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196013667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196013668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196013669 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246196013670 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 246196013671 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 246196013672 putative active site [active] 246196013673 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196013674 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196013675 active site 246196013676 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246196013677 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 246196013678 putative dimer interface [polypeptide binding]; other site 246196013679 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 246196013680 HIT family signature motif; other site 246196013681 catalytic residue [active] 246196013682 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196013683 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 246196013684 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 246196013685 Fe-S cluster binding site [ion binding]; other site 246196013686 DNA binding site [nucleotide binding] 246196013687 active site 246196013688 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196013689 SCP-2 sterol transfer family; Region: SCP2; cl01225 246196013690 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196013691 TIGR03086 family protein; Region: TIGR03086 246196013692 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 246196013693 FAD binding domain; Region: FAD_binding_4; pfam01565 246196013694 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246196013695 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 246196013696 Rhomboid family; Region: Rhomboid; pfam01694 246196013697 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196013698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013700 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 246196013701 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246196013702 FAD binding pocket [chemical binding]; other site 246196013703 FAD binding motif [chemical binding]; other site 246196013704 phosphate binding motif [ion binding]; other site 246196013705 NAD binding pocket [chemical binding]; other site 246196013706 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196013707 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 246196013708 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246196013709 ATP binding site [chemical binding]; other site 246196013710 Mg++ binding site [ion binding]; other site 246196013711 motif III; other site 246196013712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196013713 nucleotide binding region [chemical binding]; other site 246196013714 ATP-binding site [chemical binding]; other site 246196013715 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 246196013716 putative RNA binding site [nucleotide binding]; other site 246196013717 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 246196013718 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 246196013719 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 246196013720 RNase_H superfamily; Region: RNase_H_2; pfam13482 246196013721 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 246196013722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196013723 Walker A motif; other site 246196013724 ATP binding site [chemical binding]; other site 246196013725 AAA domain; Region: AAA_12; pfam13087 246196013726 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196013727 FAD binding domain; Region: FAD_binding_4; pfam01565 246196013728 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 246196013729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196013731 putative substrate translocation pore; other site 246196013732 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 246196013733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013734 putative substrate translocation pore; other site 246196013735 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 246196013736 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246196013737 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 246196013738 TPP-binding site [chemical binding]; other site 246196013739 AF0941-like; Region: AF0941-like; pfam14591 246196013740 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 246196013741 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196013742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013743 putative substrate translocation pore; other site 246196013744 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246196013745 active site 246196013746 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196013747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196013748 non-specific DNA binding site [nucleotide binding]; other site 246196013749 salt bridge; other site 246196013750 sequence-specific DNA binding site [nucleotide binding]; other site 246196013751 short chain dehydrogenase; Provisional; Region: PRK06181 246196013752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196013753 NAD(P) binding site [chemical binding]; other site 246196013754 active site 246196013755 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196013756 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 246196013757 Malic enzyme, N-terminal domain; Region: malic; pfam00390 246196013758 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 246196013759 putative NAD(P) binding site [chemical binding]; other site 246196013760 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 246196013761 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 246196013762 oligomer interface [polypeptide binding]; other site 246196013763 metal binding site [ion binding]; metal-binding site 246196013764 metal binding site [ion binding]; metal-binding site 246196013765 putative Cl binding site [ion binding]; other site 246196013766 basic sphincter; other site 246196013767 hydrophobic gate; other site 246196013768 periplasmic entrance; other site 246196013769 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 246196013770 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196013771 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246196013772 Walker A/P-loop; other site 246196013773 ATP binding site [chemical binding]; other site 246196013774 Q-loop/lid; other site 246196013775 ABC transporter signature motif; other site 246196013776 Walker B; other site 246196013777 D-loop; other site 246196013778 H-loop/switch region; other site 246196013779 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196013780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013781 dimer interface [polypeptide binding]; other site 246196013782 conserved gate region; other site 246196013783 putative PBP binding loops; other site 246196013784 ABC-ATPase subunit interface; other site 246196013785 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196013786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013787 dimer interface [polypeptide binding]; other site 246196013788 conserved gate region; other site 246196013789 putative PBP binding loops; other site 246196013790 ABC-ATPase subunit interface; other site 246196013791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196013792 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196013793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 246196013794 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 246196013795 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196013796 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 246196013797 PRC-barrel domain; Region: PRC; pfam05239 246196013798 MgtE intracellular N domain; Region: MgtE_N; smart00924 246196013799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 246196013800 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 246196013801 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 246196013802 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246196013803 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246196013804 Domain of unknown function DUF59; Region: DUF59; cl00941 246196013805 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 246196013806 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 246196013807 Walker A motif; other site 246196013808 sec-independent translocase; Provisional; Region: PRK03100 246196013809 Trypsin; Region: Trypsin; pfam00089 246196013810 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246196013811 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246196013812 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 246196013813 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 246196013814 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196013815 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196013816 DNA binding residues [nucleotide binding] 246196013817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196013818 S-adenosylmethionine binding site [chemical binding]; other site 246196013819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196013820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196013821 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196013822 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196013823 Walker A/P-loop; other site 246196013824 ATP binding site [chemical binding]; other site 246196013825 Q-loop/lid; other site 246196013826 ABC transporter signature motif; other site 246196013827 Walker B; other site 246196013828 D-loop; other site 246196013829 H-loop/switch region; other site 246196013830 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 246196013831 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 246196013832 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 246196013833 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 246196013834 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 246196013835 ligand binding site; other site 246196013836 oligomer interface; other site 246196013837 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 246196013838 dimer interface [polypeptide binding]; other site 246196013839 N-terminal domain interface [polypeptide binding]; other site 246196013840 sulfate 1 binding site; other site 246196013841 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 246196013842 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196013843 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 246196013844 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 246196013845 DivIVA domain; Region: DivI1A_domain; TIGR03544 246196013846 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 246196013847 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246196013848 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 246196013849 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 246196013850 substrate binding pocket [chemical binding]; other site 246196013851 dimer interface [polypeptide binding]; other site 246196013852 inhibitor binding site; inhibition site 246196013853 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 246196013854 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 246196013855 acyl-activating enzyme (AAE) consensus motif; other site 246196013856 putative AMP binding site [chemical binding]; other site 246196013857 putative active site [active] 246196013858 putative CoA binding site [chemical binding]; other site 246196013859 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 246196013860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196013861 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196013862 Walker A motif; other site 246196013863 ATP binding site [chemical binding]; other site 246196013864 Walker B motif; other site 246196013865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246196013866 TPR motif; other site 246196013867 binding surface 246196013868 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196013869 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196013870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196013871 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196013872 Transposase; Region: HTH_Tnp_1; cl17663 246196013873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196013874 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196013875 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 246196013876 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246196013877 dimer interface [polypeptide binding]; other site 246196013878 PYR/PP interface [polypeptide binding]; other site 246196013879 TPP binding site [chemical binding]; other site 246196013880 substrate binding site [chemical binding]; other site 246196013881 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196013882 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196013883 TPP-binding site [chemical binding]; other site 246196013884 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 246196013885 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246196013886 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196013887 ABC transporter; Region: ABC_tran_2; pfam12848 246196013888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196013889 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 246196013890 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 246196013891 metal binding site [ion binding]; metal-binding site 246196013892 putative dimer interface [polypeptide binding]; other site 246196013893 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 246196013894 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 246196013895 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 246196013896 putative trimer interface [polypeptide binding]; other site 246196013897 putative CoA binding site [chemical binding]; other site 246196013898 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 246196013899 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196013900 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196013901 active site 246196013902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196013903 Probable pheophorbidase; Region: PLN02965; cl17657 246196013904 hypothetical protein; Provisional; Region: PRK04286 246196013905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246196013906 acyl-CoA synthetase; Validated; Region: PRK07787 246196013907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196013908 acyl-activating enzyme (AAE) consensus motif; other site 246196013909 AMP binding site [chemical binding]; other site 246196013910 active site 246196013911 CoA binding site [chemical binding]; other site 246196013912 Domain of unknown function (DUF309); Region: DUF309; pfam03745 246196013913 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 246196013914 dimer interface [polypeptide binding]; other site 246196013915 active site 246196013916 ADP-ribose binding site [chemical binding]; other site 246196013917 nudix motif; other site 246196013918 metal binding site [ion binding]; metal-binding site 246196013919 Proline dehydrogenase; Region: Pro_dh; pfam01619 246196013920 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 246196013921 Glutamate binding site [chemical binding]; other site 246196013922 NAD binding site [chemical binding]; other site 246196013923 catalytic residues [active] 246196013924 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196013925 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196013926 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 246196013927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196013928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196013929 homodimer interface [polypeptide binding]; other site 246196013930 catalytic residue [active] 246196013931 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 246196013932 Ferredoxin [Energy production and conversion]; Region: COG1146 246196013933 4Fe-4S binding domain; Region: Fer4; pfam00037 246196013934 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 246196013935 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 246196013936 active site 246196013937 FMN binding site [chemical binding]; other site 246196013938 2,4-decadienoyl-CoA binding site; other site 246196013939 catalytic residue [active] 246196013940 4Fe-4S cluster binding site [ion binding]; other site 246196013941 Uncharacterized conserved protein [Function unknown]; Region: COG2353 246196013942 FO synthase; Reviewed; Region: fbiC; PRK09234 246196013943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196013944 FeS/SAM binding site; other site 246196013945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196013946 FeS/SAM binding site; other site 246196013947 adenylate kinase; Provisional; Region: PRK13808 246196013948 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 246196013949 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196013950 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 246196013951 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 246196013952 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 246196013953 G1 box; other site 246196013954 putative GEF interaction site [polypeptide binding]; other site 246196013955 GTP/Mg2+ binding site [chemical binding]; other site 246196013956 Switch I region; other site 246196013957 G2 box; other site 246196013958 G3 box; other site 246196013959 Switch II region; other site 246196013960 G4 box; other site 246196013961 G5 box; other site 246196013962 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 246196013963 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 246196013964 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 246196013965 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 246196013966 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 246196013967 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 246196013968 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 246196013969 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 246196013970 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 246196013971 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 246196013972 [4Fe-4S] binding site [ion binding]; other site 246196013973 molybdopterin cofactor binding site [chemical binding]; other site 246196013974 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 246196013975 molybdopterin cofactor binding site; other site 246196013976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196013977 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 246196013978 putative substrate translocation pore; other site 246196013979 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 246196013980 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 246196013981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196013982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196013983 DNA binding site [nucleotide binding] 246196013984 domain linker motif; other site 246196013985 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 246196013986 putative dimerization interface [polypeptide binding]; other site 246196013987 putative ligand binding site [chemical binding]; other site 246196013988 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 246196013989 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 246196013990 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 246196013991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196013992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246196013993 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246196013994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196013995 dimer interface [polypeptide binding]; other site 246196013996 conserved gate region; other site 246196013997 putative PBP binding loops; other site 246196013998 ABC-ATPase subunit interface; other site 246196013999 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196014000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014001 dimer interface [polypeptide binding]; other site 246196014002 conserved gate region; other site 246196014003 putative PBP binding loops; other site 246196014004 ABC-ATPase subunit interface; other site 246196014005 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 246196014006 active site 246196014007 8-oxo-dGMP binding site [chemical binding]; other site 246196014008 nudix motif; other site 246196014009 metal binding site [ion binding]; metal-binding site 246196014010 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 246196014011 aromatic arch; other site 246196014012 DCoH dimer interaction site [polypeptide binding]; other site 246196014013 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 246196014014 DCoH tetramer interaction site [polypeptide binding]; other site 246196014015 substrate binding site [chemical binding]; other site 246196014016 mannosyltransferase; Provisional; Region: pimE; PRK13375 246196014017 transcription termination factor Rho; Provisional; Region: PRK12678 246196014018 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 246196014019 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196014020 FMN binding site [chemical binding]; other site 246196014021 dimer interface [polypeptide binding]; other site 246196014022 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 246196014023 minor groove reading motif; other site 246196014024 helix-hairpin-helix signature motif; other site 246196014025 Histidine kinase; Region: His_kinase; pfam06580 246196014026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014027 ATP binding site [chemical binding]; other site 246196014028 Mg2+ binding site [ion binding]; other site 246196014029 G-X-G motif; other site 246196014030 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 246196014031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014032 active site 246196014033 phosphorylation site [posttranslational modification] 246196014034 intermolecular recognition site; other site 246196014035 dimerization interface [polypeptide binding]; other site 246196014036 LytTr DNA-binding domain; Region: LytTR; smart00850 246196014037 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 246196014038 Na binding site [ion binding]; other site 246196014039 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196014040 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196014041 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 246196014042 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 246196014043 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 246196014044 putative NAD(P) binding site [chemical binding]; other site 246196014045 dimer interface [polypeptide binding]; other site 246196014046 Protein of unknown function, DUF485; Region: DUF485; pfam04341 246196014047 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 246196014048 Na binding site [ion binding]; other site 246196014049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196014051 putative substrate translocation pore; other site 246196014052 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246196014053 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196014054 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196014055 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246196014056 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196014057 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 246196014058 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246196014059 Predicted transcriptional regulators [Transcription]; Region: COG1725 246196014060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196014061 DNA-binding site [nucleotide binding]; DNA binding site 246196014062 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 246196014063 NAD+ binding site [chemical binding]; other site 246196014064 substrate binding site [chemical binding]; other site 246196014065 Zn binding site [ion binding]; other site 246196014066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014067 S-adenosylmethionine binding site [chemical binding]; other site 246196014068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014070 WHG domain; Region: WHG; pfam13305 246196014071 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 246196014072 MMPL family; Region: MMPL; cl14618 246196014073 MMPL family; Region: MMPL; cl14618 246196014074 Predicted membrane protein [Function unknown]; Region: COG2259 246196014075 Transposase [DNA replication, recombination, and repair]; Region: COG5421 246196014076 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 246196014077 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196014078 FMN binding site [chemical binding]; other site 246196014079 substrate binding site [chemical binding]; other site 246196014080 putative catalytic residue [active] 246196014081 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 246196014082 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 246196014083 NAD binding site [chemical binding]; other site 246196014084 homodimer interface [polypeptide binding]; other site 246196014085 homotetramer interface [polypeptide binding]; other site 246196014086 active site 246196014087 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196014088 enoyl-CoA hydratase; Provisional; Region: PRK06688 246196014089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014090 substrate binding site [chemical binding]; other site 246196014091 oxyanion hole (OAH) forming residues; other site 246196014092 trimer interface [polypeptide binding]; other site 246196014093 HicB family; Region: HicB; pfam05534 246196014094 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196014095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014096 putative substrate translocation pore; other site 246196014097 CAAX protease self-immunity; Region: Abi; pfam02517 246196014098 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196014099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196014100 NAD(P) binding site [chemical binding]; other site 246196014101 active site 246196014102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196014105 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196014106 active site 246196014107 catalytic tetrad [active] 246196014108 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 246196014109 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 246196014110 trimer interface [polypeptide binding]; other site 246196014111 putative metal binding site [ion binding]; other site 246196014112 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 246196014113 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196014114 conserved cys residue [active] 246196014115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196014116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196014118 putative substrate translocation pore; other site 246196014119 Fasciclin domain; Region: Fasciclin; pfam02469 246196014120 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196014121 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196014122 active site 246196014123 enoyl-CoA hydratase; Provisional; Region: PRK08252 246196014124 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014125 substrate binding site [chemical binding]; other site 246196014126 oxyanion hole (OAH) forming residues; other site 246196014127 trimer interface [polypeptide binding]; other site 246196014128 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 246196014129 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196014130 dimer interface [polypeptide binding]; other site 246196014131 active site 246196014132 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196014133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196014134 DNA-binding site [nucleotide binding]; DNA binding site 246196014135 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196014136 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 246196014137 Predicted membrane protein [Function unknown]; Region: COG2259 246196014138 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 246196014139 classical (c) SDRs; Region: SDR_c; cd05233 246196014140 NAD(P) binding site [chemical binding]; other site 246196014141 active site 246196014142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014144 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196014145 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196014146 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 246196014147 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196014148 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196014149 hypothetical protein; Provisional; Region: PRK06149 246196014150 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 246196014151 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196014152 inhibitor-cofactor binding pocket; inhibition site 246196014153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196014154 catalytic residue [active] 246196014155 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196014156 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 246196014157 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196014158 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196014159 DNA binding residues [nucleotide binding] 246196014160 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 246196014161 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196014162 active site 246196014163 metal binding site [ion binding]; metal-binding site 246196014164 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 246196014165 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196014166 RibD C-terminal domain; Region: RibD_C; cl17279 246196014167 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196014168 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196014169 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196014170 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246196014171 GTP-binding protein YchF; Reviewed; Region: PRK09601 246196014172 YchF GTPase; Region: YchF; cd01900 246196014173 G1 box; other site 246196014174 GTP/Mg2+ binding site [chemical binding]; other site 246196014175 Switch I region; other site 246196014176 G2 box; other site 246196014177 Switch II region; other site 246196014178 G3 box; other site 246196014179 G4 box; other site 246196014180 G5 box; other site 246196014181 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 246196014182 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 246196014183 Fe-S cluster binding site [ion binding]; other site 246196014184 substrate binding site [chemical binding]; other site 246196014185 catalytic site [active] 246196014186 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 246196014187 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 246196014188 generic binding surface II; other site 246196014189 generic binding surface I; other site 246196014190 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 246196014191 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 246196014192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196014193 putative NAD(P) binding site [chemical binding]; other site 246196014194 active site 246196014195 putative substrate binding site [chemical binding]; other site 246196014196 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 246196014197 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 246196014198 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196014199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196014200 NAD(P) binding site [chemical binding]; other site 246196014201 active site 246196014202 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196014203 classical (c) SDRs; Region: SDR_c; cd05233 246196014204 NAD(P) binding site [chemical binding]; other site 246196014205 active site 246196014206 short chain dehydrogenase; Provisional; Region: PRK07825 246196014207 classical (c) SDRs; Region: SDR_c; cd05233 246196014208 NAD(P) binding site [chemical binding]; other site 246196014209 active site 246196014210 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246196014211 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246196014212 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 246196014213 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 246196014214 putative active site [active] 246196014215 fumarate hydratase; Reviewed; Region: fumC; PRK00485 246196014216 Class II fumarases; Region: Fumarase_classII; cd01362 246196014217 active site 246196014218 tetramer interface [polypeptide binding]; other site 246196014219 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246196014220 GAF domain; Region: GAF_3; pfam13492 246196014221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196014222 Histidine kinase; Region: HisKA_3; pfam07730 246196014223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014224 ATP binding site [chemical binding]; other site 246196014225 Mg2+ binding site [ion binding]; other site 246196014226 G-X-G motif; other site 246196014227 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196014228 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196014229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196014230 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 246196014231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196014232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014233 active site 246196014234 phosphorylation site [posttranslational modification] 246196014235 intermolecular recognition site; other site 246196014236 dimerization interface [polypeptide binding]; other site 246196014237 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196014238 DNA binding residues [nucleotide binding] 246196014239 dimerization interface [polypeptide binding]; other site 246196014240 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196014241 Ligand Binding Site [chemical binding]; other site 246196014242 Universal stress protein family; Region: Usp; pfam00582 246196014243 Nitroreductase family; Region: Nitroreductase; pfam00881 246196014244 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 246196014245 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 246196014246 putative active site [active] 246196014247 PhoH-like protein; Region: PhoH; pfam02562 246196014248 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 246196014249 dinuclear metal binding motif [ion binding]; other site 246196014250 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 246196014251 dimer interface [polypeptide binding]; other site 246196014252 active site 246196014253 glycine-pyridoxal phosphate binding site [chemical binding]; other site 246196014254 folate binding site [chemical binding]; other site 246196014255 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 246196014256 ATP-binding site [chemical binding]; other site 246196014257 CoA-binding site [chemical binding]; other site 246196014258 Mg2+-binding site [ion binding]; other site 246196014259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196014260 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 246196014261 active site 246196014262 dimer interface [polypeptide binding]; other site 246196014263 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 246196014264 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196014265 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 246196014266 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 246196014267 catalytic residues [active] 246196014268 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 246196014269 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 246196014270 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 246196014271 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 246196014272 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246196014273 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 246196014274 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246196014275 homodimer interface [polypeptide binding]; other site 246196014276 substrate-cofactor binding pocket; other site 246196014277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196014278 catalytic residue [active] 246196014279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196014280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196014281 active site 246196014282 RDD family; Region: RDD; pfam06271 246196014283 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 246196014284 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 246196014285 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246196014286 dimer interface [polypeptide binding]; other site 246196014287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196014288 catalytic residue [active] 246196014289 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 246196014290 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 246196014291 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196014292 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 246196014293 active site 246196014294 catalytic triad [active] 246196014295 oxyanion hole [active] 246196014296 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 246196014297 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196014298 dimer interface [polypeptide binding]; other site 246196014299 active site 246196014300 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 246196014301 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 246196014302 ATP-grasp domain; Region: ATP-grasp; pfam02222 246196014303 Predicted membrane protein [Function unknown]; Region: COG4760 246196014304 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 246196014305 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014306 substrate binding site [chemical binding]; other site 246196014307 oxyanion hole (OAH) forming residues; other site 246196014308 trimer interface [polypeptide binding]; other site 246196014309 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 246196014310 enoyl-CoA hydratase; Provisional; Region: PRK05862 246196014311 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014312 substrate binding site [chemical binding]; other site 246196014313 oxyanion hole (OAH) forming residues; other site 246196014314 trimer interface [polypeptide binding]; other site 246196014315 Predicted membrane protein [Function unknown]; Region: COG4425 246196014316 Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420 246196014317 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 246196014318 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196014319 active site residue [active] 246196014320 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 246196014321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014323 Predicted acyl esterases [General function prediction only]; Region: COG2936 246196014324 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 246196014325 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 246196014326 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 246196014327 active site 246196014328 nucleophile elbow; other site 246196014329 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 246196014330 Patatin-like phospholipase; Region: Patatin; pfam01734 246196014331 active site 246196014332 nucleophile elbow; other site 246196014333 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196014334 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 246196014335 putative NAD(P) binding site [chemical binding]; other site 246196014336 catalytic Zn binding site [ion binding]; other site 246196014337 structural Zn binding site [ion binding]; other site 246196014338 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196014339 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196014340 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246196014341 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246196014342 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 246196014343 AAA ATPase domain; Region: AAA_16; pfam13191 246196014344 PAS domain; Region: PAS_9; pfam13426 246196014345 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196014346 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 246196014347 dimer interface [polypeptide binding]; other site 246196014348 acyl-activating enzyme (AAE) consensus motif; other site 246196014349 putative active site [active] 246196014350 AMP binding site [chemical binding]; other site 246196014351 putative CoA binding site [chemical binding]; other site 246196014352 acyl-CoA synthetase; Validated; Region: PRK05852 246196014353 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196014354 acyl-activating enzyme (AAE) consensus motif; other site 246196014355 AMP binding site [chemical binding]; other site 246196014356 active site 246196014357 CoA binding site [chemical binding]; other site 246196014358 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 246196014359 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196014360 PYR/PP interface [polypeptide binding]; other site 246196014361 dimer interface [polypeptide binding]; other site 246196014362 TPP binding site [chemical binding]; other site 246196014363 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196014364 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 246196014365 TPP-binding site; other site 246196014366 dimer interface [polypeptide binding]; other site 246196014367 short chain dehydrogenase; Provisional; Region: PRK12937 246196014368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196014369 NAD(P) binding site [chemical binding]; other site 246196014370 active site 246196014371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014373 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 246196014374 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 246196014375 Na binding site [ion binding]; other site 246196014376 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 246196014377 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 246196014378 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 246196014379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014380 ATP binding site [chemical binding]; other site 246196014381 Mg2+ binding site [ion binding]; other site 246196014382 G-X-G motif; other site 246196014383 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 246196014384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014385 active site 246196014386 phosphorylation site [posttranslational modification] 246196014387 intermolecular recognition site; other site 246196014388 dimerization interface [polypeptide binding]; other site 246196014389 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196014390 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246196014391 choline dehydrogenase; Validated; Region: PRK02106 246196014392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196014393 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196014394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014396 TIGR03032 family protein; Region: TIGR03032 246196014397 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 246196014398 Predicted transcriptional regulator [Transcription]; Region: COG2345 246196014399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196014400 dimerization interface [polypeptide binding]; other site 246196014401 putative DNA binding site [nucleotide binding]; other site 246196014402 putative Zn2+ binding site [ion binding]; other site 246196014403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014404 S-adenosylmethionine binding site [chemical binding]; other site 246196014405 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 246196014406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196014407 Walker A/P-loop; other site 246196014408 ATP binding site [chemical binding]; other site 246196014409 Q-loop/lid; other site 246196014410 ABC transporter signature motif; other site 246196014411 Walker B; other site 246196014412 D-loop; other site 246196014413 H-loop/switch region; other site 246196014414 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196014415 putative active site [active] 246196014416 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 246196014417 amidase catalytic site [active] 246196014418 Zn binding residues [ion binding]; other site 246196014419 substrate binding site [chemical binding]; other site 246196014420 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246196014421 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 246196014422 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196014423 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196014424 Walker A/P-loop; other site 246196014425 ATP binding site [chemical binding]; other site 246196014426 Q-loop/lid; other site 246196014427 ABC transporter signature motif; other site 246196014428 Walker B; other site 246196014429 D-loop; other site 246196014430 H-loop/switch region; other site 246196014431 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196014432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196014433 substrate binding pocket [chemical binding]; other site 246196014434 membrane-bound complex binding site; other site 246196014435 hinge residues; other site 246196014436 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196014437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014438 dimer interface [polypeptide binding]; other site 246196014439 conserved gate region; other site 246196014440 putative PBP binding loops; other site 246196014441 ABC-ATPase subunit interface; other site 246196014442 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196014443 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196014444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 246196014445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 246196014446 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 246196014447 Predicted membrane protein [Function unknown]; Region: COG2119 246196014448 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 246196014449 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 246196014450 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196014451 dimer interface [polypeptide binding]; other site 246196014452 active site 246196014453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014454 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 246196014455 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246196014456 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 246196014457 UreI/AmiS family, subgroup 2. Putative transporters related to proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like_2; cd13429 246196014458 hexamer interface [polypeptide binding]; other site 246196014459 transport channel [chemical binding]; other site 246196014460 constriction site 1 [chemical binding]; other site 246196014461 constriction site 2 [chemical binding]; other site 246196014462 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196014463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196014464 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 246196014465 putative ligand binding site [chemical binding]; other site 246196014466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014468 Transcription initiation factor IIF, beta subunit; Region: TFIIF_beta; cl02122 246196014469 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196014470 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196014471 Sulfur oxidation protein SoxY; Region: SoxY; cl19207 246196014472 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 246196014473 active site 246196014474 catalytic residues [active] 246196014475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014477 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 246196014478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014479 putative substrate translocation pore; other site 246196014480 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196014481 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 246196014482 dimer interface [polypeptide binding]; other site 246196014483 acyl-activating enzyme (AAE) consensus motif; other site 246196014484 putative active site [active] 246196014485 AMP binding site [chemical binding]; other site 246196014486 putative CoA binding site [chemical binding]; other site 246196014487 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196014488 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196014489 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246196014490 PE-PPE domain; Region: PE-PPE; pfam08237 246196014491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196014492 Coenzyme A binding pocket [chemical binding]; other site 246196014493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014494 S-adenosylmethionine binding site [chemical binding]; other site 246196014495 O-methyltransferase; Region: Methyltransf_2; pfam00891 246196014496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014497 S-adenosylmethionine binding site [chemical binding]; other site 246196014498 Sec24-related protein; Provisional; Region: PTZ00395 246196014499 Excalibur calcium-binding domain; Region: Excalibur; cl05460 246196014500 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl19826 246196014501 cyanate hydratase; Validated; Region: PRK02866 246196014502 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 246196014503 oligomer interface [polypeptide binding]; other site 246196014504 active site 246196014505 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 246196014506 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 246196014507 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 246196014508 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 246196014509 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196014510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196014511 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 246196014512 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196014513 substrate binding pocket [chemical binding]; other site 246196014514 membrane-bound complex binding site; other site 246196014515 hinge residues; other site 246196014516 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196014517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014518 dimer interface [polypeptide binding]; other site 246196014519 conserved gate region; other site 246196014520 putative PBP binding loops; other site 246196014521 ABC-ATPase subunit interface; other site 246196014522 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 246196014523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014524 dimer interface [polypeptide binding]; other site 246196014525 conserved gate region; other site 246196014526 putative PBP binding loops; other site 246196014527 ABC-ATPase subunit interface; other site 246196014528 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196014529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196014530 Walker A/P-loop; other site 246196014531 ATP binding site [chemical binding]; other site 246196014532 Q-loop/lid; other site 246196014533 ABC transporter signature motif; other site 246196014534 Walker B; other site 246196014535 D-loop; other site 246196014536 H-loop/switch region; other site 246196014537 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 246196014538 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 246196014539 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 246196014540 Ligand Binding Site [chemical binding]; other site 246196014541 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 246196014542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014543 ATP binding site [chemical binding]; other site 246196014544 Mg2+ binding site [ion binding]; other site 246196014545 G-X-G motif; other site 246196014546 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 246196014547 putative active site [active] 246196014548 catalytic triad [active] 246196014549 putative dimer interface [polypeptide binding]; other site 246196014550 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196014551 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196014552 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196014553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196014554 DNA-binding site [nucleotide binding]; DNA binding site 246196014555 FCD domain; Region: FCD; pfam07729 246196014556 Domain of unknown function (DUF385); Region: DUF385; cl04387 246196014557 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196014558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196014559 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196014560 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196014561 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196014562 classical (c) SDRs; Region: SDR_c; cd05233 246196014563 NAD(P) binding site [chemical binding]; other site 246196014564 active site 246196014565 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246196014566 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246196014567 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196014568 active site residue [active] 246196014569 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196014570 active site residue [active] 246196014571 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 246196014572 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196014573 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 246196014574 putative homodimer interface [polypeptide binding]; other site 246196014575 putative homotetramer interface [polypeptide binding]; other site 246196014576 putative allosteric switch controlling residues; other site 246196014577 putative metal binding site [ion binding]; other site 246196014578 putative homodimer-homodimer interface [polypeptide binding]; other site 246196014579 Domain of unknown function DUF302; Region: DUF302; pfam03625 246196014580 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 246196014581 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 246196014582 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 246196014583 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196014584 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 246196014585 K+-transporting ATPase, c chain; Region: KdpC; cl00944 246196014586 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 246196014587 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 246196014588 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 246196014589 Ligand Binding Site [chemical binding]; other site 246196014590 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 246196014591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196014592 dimer interface [polypeptide binding]; other site 246196014593 phosphorylation site [posttranslational modification] 246196014594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014595 ATP binding site [chemical binding]; other site 246196014596 Mg2+ binding site [ion binding]; other site 246196014597 G-X-G motif; other site 246196014598 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 246196014599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014600 active site 246196014601 phosphorylation site [posttranslational modification] 246196014602 intermolecular recognition site; other site 246196014603 dimerization interface [polypeptide binding]; other site 246196014604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196014605 DNA binding site [nucleotide binding] 246196014606 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 246196014607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196014608 nucleotide binding region [chemical binding]; other site 246196014609 ATP-binding site [chemical binding]; other site 246196014610 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196014611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196014612 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 246196014613 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196014614 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 246196014615 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196014616 ATP binding site [chemical binding]; other site 246196014617 putative Mg++ binding site [ion binding]; other site 246196014618 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246196014619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196014620 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 246196014621 hydrophobic ligand binding site; other site 246196014622 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196014623 classical (c) SDRs; Region: SDR_c; cd05233 246196014624 NAD(P) binding site [chemical binding]; other site 246196014625 active site 246196014626 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 246196014627 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 246196014628 acyl-activating enzyme (AAE) consensus motif; other site 246196014629 putative AMP binding site [chemical binding]; other site 246196014630 putative active site [active] 246196014631 putative CoA binding site [chemical binding]; other site 246196014632 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 246196014633 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196014634 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 246196014635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196014636 dimerization interface [polypeptide binding]; other site 246196014637 putative DNA binding site [nucleotide binding]; other site 246196014638 putative Zn2+ binding site [ion binding]; other site 246196014639 ZIP Zinc transporter; Region: Zip; cl00437 246196014640 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 246196014641 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 246196014642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196014643 FeS/SAM binding site; other site 246196014644 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 246196014645 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 246196014646 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 246196014647 Septum formation initiator; Region: DivIC; pfam04977 246196014648 Uncharacterized conserved protein [Function unknown]; Region: COG1507 246196014649 enolase; Provisional; Region: eno; PRK00077 246196014650 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 246196014651 dimer interface [polypeptide binding]; other site 246196014652 metal binding site [ion binding]; metal-binding site 246196014653 substrate binding pocket [chemical binding]; other site 246196014654 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 246196014655 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246196014656 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246196014657 Iron permease FTR1 family; Region: FTR1; cl00475 246196014658 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 246196014659 PE-PPE domain; Region: PE-PPE; pfam08237 246196014660 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 246196014661 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 246196014662 homodimer interface [polypeptide binding]; other site 246196014663 metal binding site [ion binding]; metal-binding site 246196014664 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 246196014665 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 246196014666 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196014667 ATP binding site [chemical binding]; other site 246196014668 putative Mg++ binding site [ion binding]; other site 246196014669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196014670 nucleotide binding region [chemical binding]; other site 246196014671 ATP-binding site [chemical binding]; other site 246196014672 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 246196014673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014675 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 246196014676 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 246196014677 Substrate binding site; other site 246196014678 Mg++ binding site; other site 246196014679 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 246196014680 active site 246196014681 substrate binding site [chemical binding]; other site 246196014682 CoA binding site [chemical binding]; other site 246196014683 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 246196014684 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 246196014685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196014686 active site 246196014687 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 246196014688 catalytic residues [active] 246196014689 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 246196014690 short chain dehydrogenase; Provisional; Region: PRK06500 246196014691 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 246196014692 putative NAD(P) binding site [chemical binding]; other site 246196014693 active site 246196014694 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 246196014695 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 246196014696 5S rRNA interface [nucleotide binding]; other site 246196014697 CTC domain interface [polypeptide binding]; other site 246196014698 L16 interface [polypeptide binding]; other site 246196014699 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 246196014700 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 246196014701 putative active site [active] 246196014702 catalytic residue [active] 246196014703 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 246196014704 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 246196014705 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 246196014706 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196014707 acyl-activating enzyme (AAE) consensus motif; other site 246196014708 active site 246196014709 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 246196014710 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 246196014711 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 246196014712 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196014713 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196014714 active site 246196014715 ATP binding site [chemical binding]; other site 246196014716 substrate binding site [chemical binding]; other site 246196014717 activation loop (A-loop); other site 246196014718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196014719 S-adenosylmethionine binding site [chemical binding]; other site 246196014720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 246196014721 Domain of unknown function (DUF348); Region: DUF348; pfam03990 246196014722 Domain of unknown function (DUF348); Region: DUF348; pfam03990 246196014723 Domain of unknown function (DUF348); Region: DUF348; pfam03990 246196014724 G5 domain; Region: G5; pfam07501 246196014725 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 246196014726 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 246196014727 active site 246196014728 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 246196014729 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 246196014730 active site 246196014731 HIGH motif; other site 246196014732 KMSKS motif; other site 246196014733 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 246196014734 tRNA binding surface [nucleotide binding]; other site 246196014735 anticodon binding site; other site 246196014736 glutamate dehydrogenase; Provisional; Region: PRK09414 246196014737 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 246196014738 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 246196014739 NAD(P) binding site [chemical binding]; other site 246196014740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 246196014741 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 246196014742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196014743 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 246196014744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196014745 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196014746 DNA binding residues [nucleotide binding] 246196014747 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196014748 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 246196014749 chorismate binding enzyme; Region: Chorismate_bind; cl10555 246196014750 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 246196014751 putative SAM binding site [chemical binding]; other site 246196014752 putative homodimer interface [polypeptide binding]; other site 246196014753 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 246196014754 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 246196014755 arginine deiminase; Provisional; Region: PRK01388 246196014756 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 246196014757 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 246196014758 DNA binding residues [nucleotide binding] 246196014759 dimer interface [polypeptide binding]; other site 246196014760 [2Fe-2S] cluster binding site [ion binding]; other site 246196014761 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 246196014762 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 246196014763 PE-PPE domain; Region: PE-PPE; pfam08237 246196014764 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 246196014765 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 246196014766 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 246196014767 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 246196014768 shikimate binding site; other site 246196014769 NAD(P) binding site [chemical binding]; other site 246196014770 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196014771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196014772 ligand binding site [chemical binding]; other site 246196014773 flexible hinge region; other site 246196014774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196014775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 246196014776 Predicted permeases [General function prediction only]; Region: RarD; COG2962 246196014777 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196014778 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196014779 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196014780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196014781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196014782 putative substrate translocation pore; other site 246196014783 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196014784 classical (c) SDRs; Region: SDR_c; cd05233 246196014785 NAD(P) binding site [chemical binding]; other site 246196014786 active site 246196014787 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 246196014788 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246196014789 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 246196014790 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246196014791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196014792 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 246196014793 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246196014794 dimer interface [polypeptide binding]; other site 246196014795 putative functional site; other site 246196014796 putative MPT binding site; other site 246196014797 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 246196014798 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 246196014799 active site 246196014800 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 246196014801 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 246196014802 Spore germination protein; Region: Spore_permease; cl17796 246196014803 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196014804 Ligand Binding Site [chemical binding]; other site 246196014805 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196014806 Ligand Binding Site [chemical binding]; other site 246196014807 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196014808 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196014809 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196014810 glyoxylate carboligase; Provisional; Region: PRK11269 246196014811 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246196014812 PYR/PP interface [polypeptide binding]; other site 246196014813 dimer interface [polypeptide binding]; other site 246196014814 TPP binding site [chemical binding]; other site 246196014815 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196014816 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196014817 TPP-binding site [chemical binding]; other site 246196014818 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196014819 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 246196014820 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196014821 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 246196014822 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 246196014823 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 246196014824 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 246196014825 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 246196014826 MspA; Region: MspA; pfam09203 246196014827 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 246196014828 MPT binding site; other site 246196014829 trimer interface [polypeptide binding]; other site 246196014830 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246196014831 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246196014832 Trypsin-like peptidase domain; Region: Trypsin_2; cl19303 246196014833 PDZ domain; Region: PDZ_2; pfam13180 246196014834 protein binding site [polypeptide binding]; other site 246196014835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196014836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196014837 dimerization interface [polypeptide binding]; other site 246196014838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196014839 dimer interface [polypeptide binding]; other site 246196014840 phosphorylation site [posttranslational modification] 246196014841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196014842 ATP binding site [chemical binding]; other site 246196014843 Mg2+ binding site [ion binding]; other site 246196014844 G-X-G motif; other site 246196014845 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196014846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196014847 active site 246196014848 phosphorylation site [posttranslational modification] 246196014849 intermolecular recognition site; other site 246196014850 dimerization interface [polypeptide binding]; other site 246196014851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196014852 DNA binding site [nucleotide binding] 246196014853 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 246196014854 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 246196014855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196014856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196014857 active site 246196014858 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 246196014859 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196014860 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196014861 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 246196014862 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196014863 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196014864 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 246196014865 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196014866 carboxyltransferase (CT) interaction site; other site 246196014867 biotinylation site [posttranslational modification]; other site 246196014868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196014869 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196014870 active site 246196014871 enoyl-CoA hydratase; Provisional; Region: PRK07827 246196014872 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196014873 substrate binding site [chemical binding]; other site 246196014874 oxyanion hole (OAH) forming residues; other site 246196014875 trimer interface [polypeptide binding]; other site 246196014876 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246196014877 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246196014878 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196014879 PE-PPE domain; Region: PE-PPE; pfam08237 246196014880 PE-PPE domain; Region: PE-PPE; pfam08237 246196014881 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196014882 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246196014883 NAD(P) binding site [chemical binding]; other site 246196014884 active site 246196014885 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196014886 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 246196014887 Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase; Region: TM_EphA1; cl17164 246196014888 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 246196014889 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 246196014890 putative active site [active] 246196014891 putative metal binding site [ion binding]; other site 246196014892 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196014893 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 246196014894 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 246196014895 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246196014896 metal ion-dependent adhesion site (MIDAS); other site 246196014897 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 246196014898 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 246196014899 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196014900 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196014901 active site 246196014902 ATP binding site [chemical binding]; other site 246196014903 substrate binding site [chemical binding]; other site 246196014904 activation loop (A-loop); other site 246196014905 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 246196014906 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 246196014907 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 246196014908 purine monophosphate binding site [chemical binding]; other site 246196014909 dimer interface [polypeptide binding]; other site 246196014910 putative catalytic residues [active] 246196014911 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 246196014912 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 246196014913 active site 246196014914 substrate binding site [chemical binding]; other site 246196014915 cosubstrate binding site; other site 246196014916 catalytic site [active] 246196014917 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 246196014918 active site 246196014919 dimer interface [polypeptide binding]; other site 246196014920 non-prolyl cis peptide bond; other site 246196014921 insertion regions; other site 246196014922 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 246196014923 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 246196014924 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246196014925 active site 246196014926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196014927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196014928 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 246196014929 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196014930 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 246196014931 CoA binding domain; Region: CoA_binding; smart00881 246196014932 CoA-ligase; Region: Ligase_CoA; pfam00549 246196014933 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 246196014934 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 246196014935 CoA-ligase; Region: Ligase_CoA; pfam00549 246196014936 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246196014937 Peptidase family M23; Region: Peptidase_M23; pfam01551 246196014938 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246196014939 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196014940 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196014941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196014942 dimer interface [polypeptide binding]; other site 246196014943 conserved gate region; other site 246196014944 putative PBP binding loops; other site 246196014945 ABC-ATPase subunit interface; other site 246196014946 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196014947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196014948 Walker A/P-loop; other site 246196014949 ATP binding site [chemical binding]; other site 246196014950 Q-loop/lid; other site 246196014951 ABC transporter signature motif; other site 246196014952 Walker B; other site 246196014953 D-loop; other site 246196014954 H-loop/switch region; other site 246196014955 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 246196014956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196014957 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246196014958 Ferredoxin [Energy production and conversion]; Region: COG1146 246196014959 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 246196014960 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 246196014961 Part of AAA domain; Region: AAA_19; pfam13245 246196014962 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 246196014963 Chorismate mutase type II; Region: CM_2; cl00693 246196014964 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196014965 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 246196014966 active site 246196014967 catalytic triad [active] 246196014968 oxyanion hole [active] 246196014969 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246196014970 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 246196014971 tetramerization interface [polypeptide binding]; other site 246196014972 NAD(P) binding site [chemical binding]; other site 246196014973 catalytic residues [active] 246196014974 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 246196014975 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 246196014976 active site 246196014977 dimer interface [polypeptide binding]; other site 246196014978 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 246196014979 dimer interface [polypeptide binding]; other site 246196014980 active site 246196014981 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196014982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196014983 non-specific DNA binding site [nucleotide binding]; other site 246196014984 salt bridge; other site 246196014985 sequence-specific DNA binding site [nucleotide binding]; other site 246196014986 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196014987 short chain dehydrogenase; Provisional; Region: PRK08251 246196014988 NAD(P) binding site [chemical binding]; other site 246196014989 active site 246196014990 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 246196014991 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 246196014992 putative DNA binding site [nucleotide binding]; other site 246196014993 catalytic residue [active] 246196014994 putative H2TH interface [polypeptide binding]; other site 246196014995 putative catalytic residues [active] 246196014996 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246196014997 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246196014998 Predicted membrane protein [Function unknown]; Region: COG1289 246196014999 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246196015000 Predicted membrane protein [Function unknown]; Region: COG1950 246196015001 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 246196015002 active site 246196015003 SAM binding site [chemical binding]; other site 246196015004 homodimer interface [polypeptide binding]; other site 246196015005 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 246196015006 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 246196015007 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246196015008 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 246196015009 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 246196015010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196015011 PAS domain; Region: PAS_9; pfam13426 246196015012 putative active site [active] 246196015013 heme pocket [chemical binding]; other site 246196015014 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 246196015015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246196015016 PAS domain; Region: PAS_9; pfam13426 246196015017 putative active site [active] 246196015018 heme pocket [chemical binding]; other site 246196015019 GAF domain; Region: GAF_2; pfam13185 246196015020 ANTAR domain; Region: ANTAR; pfam03861 246196015021 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196015022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015023 putative substrate translocation pore; other site 246196015024 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 246196015025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015026 putative substrate translocation pore; other site 246196015027 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 246196015028 RNA/DNA hybrid binding site [nucleotide binding]; other site 246196015029 active site 246196015030 HPP family; Region: HPP; pfam04982 246196015031 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 246196015032 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196015033 conserved cys residue [active] 246196015034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196015035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196015036 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 246196015037 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 246196015038 heme-binding site [chemical binding]; other site 246196015039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196015040 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015043 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196015044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015045 NAD(P) binding site [chemical binding]; other site 246196015046 active site 246196015047 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196015048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015049 NAD(P) binding site [chemical binding]; other site 246196015050 active site 246196015051 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 246196015052 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 246196015053 nucleotide binding site [chemical binding]; other site 246196015054 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 246196015055 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 246196015056 active site 246196015057 DNA binding site [nucleotide binding] 246196015058 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 246196015059 DNA binding site [nucleotide binding] 246196015060 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246196015061 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246196015062 Walker A/P-loop; other site 246196015063 ATP binding site [chemical binding]; other site 246196015064 Q-loop/lid; other site 246196015065 ABC transporter signature motif; other site 246196015066 Walker B; other site 246196015067 D-loop; other site 246196015068 H-loop/switch region; other site 246196015069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246196015070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015071 dimer interface [polypeptide binding]; other site 246196015072 conserved gate region; other site 246196015073 putative PBP binding loops; other site 246196015074 ABC-ATPase subunit interface; other site 246196015075 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246196015076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015077 dimer interface [polypeptide binding]; other site 246196015078 conserved gate region; other site 246196015079 putative PBP binding loops; other site 246196015080 ABC-ATPase subunit interface; other site 246196015081 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246196015082 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246196015083 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 246196015084 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246196015085 DNA binding residues [nucleotide binding] 246196015086 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 246196015087 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 246196015088 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 246196015089 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 246196015090 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 246196015091 putative substrate binding site [chemical binding]; other site 246196015092 putative ATP binding site [chemical binding]; other site 246196015093 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015095 putative DNA binding site [nucleotide binding]; other site 246196015096 putative Zn2+ binding site [ion binding]; other site 246196015097 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 246196015098 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 246196015099 putative DNA binding site [nucleotide binding]; other site 246196015100 putative homodimer interface [polypeptide binding]; other site 246196015101 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 246196015102 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 246196015103 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196015104 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196015105 active site 246196015106 short chain dehydrogenase; Provisional; Region: PRK07814 246196015107 classical (c) SDRs; Region: SDR_c; cd05233 246196015108 NAD(P) binding site [chemical binding]; other site 246196015109 active site 246196015110 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246196015111 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246196015112 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 246196015113 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 246196015114 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 246196015115 putative active site pocket [active] 246196015116 dimerization interface [polypeptide binding]; other site 246196015117 putative catalytic residue [active] 246196015118 Protein of unknown function (DUF867); Region: DUF867; pfam05908 246196015119 carboxylate-amine ligase; Provisional; Region: PRK13517 246196015120 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 246196015121 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246196015122 iron-sulfur cluster [ion binding]; other site 246196015123 [2Fe-2S] cluster binding site [ion binding]; other site 246196015124 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 246196015125 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246196015126 PYR/PP interface [polypeptide binding]; other site 246196015127 tetramer interface [polypeptide binding]; other site 246196015128 dimer interface [polypeptide binding]; other site 246196015129 TPP binding site [chemical binding]; other site 246196015130 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196015131 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246196015132 TPP-binding site [chemical binding]; other site 246196015133 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 246196015134 iron-sulfur cluster [ion binding]; other site 246196015135 [2Fe-2S] cluster binding site [ion binding]; other site 246196015136 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246196015137 active site 246196015138 FMN binding site [chemical binding]; other site 246196015139 substrate binding site [chemical binding]; other site 246196015140 3Fe-4S cluster binding site [ion binding]; other site 246196015141 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196015143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015144 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246196015145 NAD(P) binding site [chemical binding]; other site 246196015146 active site 246196015147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015149 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 246196015150 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015151 dimerization interface [polypeptide binding]; other site 246196015152 putative DNA binding site [nucleotide binding]; other site 246196015153 putative Zn2+ binding site [ion binding]; other site 246196015154 Cation efflux family; Region: Cation_efflux; cl00316 246196015155 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 246196015156 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 246196015157 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 246196015158 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 246196015159 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196015160 active site 246196015161 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 246196015162 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196015163 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196015164 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246196015165 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246196015166 putative dimer interface [polypeptide binding]; other site 246196015167 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246196015168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246196015169 transketolase; Reviewed; Region: PRK12754 246196015170 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 246196015171 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 246196015172 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246196015173 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246196015174 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 246196015175 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196015176 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196015177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015178 active site 246196015179 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 246196015180 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015181 active site 246196015182 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196015183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015184 substrate binding site [chemical binding]; other site 246196015185 oxyanion hole (OAH) forming residues; other site 246196015186 trimer interface [polypeptide binding]; other site 246196015187 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196015188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015189 active site 246196015190 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 246196015191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015192 active site 246196015193 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196015194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015195 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196015196 NAD(P) binding site [chemical binding]; other site 246196015197 active site 246196015198 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196015199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196015200 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 246196015201 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196015202 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246196015203 [2Fe-2S] cluster binding site [ion binding]; other site 246196015204 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246196015205 hydrophobic ligand binding site; other site 246196015206 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196015207 classical (c) SDRs; Region: SDR_c; cd05233 246196015208 NAD(P) binding site [chemical binding]; other site 246196015209 active site 246196015210 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196015211 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196015212 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 246196015213 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196015214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196015215 DNA-binding site [nucleotide binding]; DNA binding site 246196015216 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 246196015217 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 246196015218 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 246196015219 acyl-activating enzyme (AAE) consensus motif; other site 246196015220 putative AMP binding site [chemical binding]; other site 246196015221 putative active site [active] 246196015222 putative CoA binding site [chemical binding]; other site 246196015223 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 246196015224 classical (c) SDRs; Region: SDR_c; cd05233 246196015225 NAD(P) binding site [chemical binding]; other site 246196015226 active site 246196015227 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246196015228 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246196015229 acyl-activating enzyme (AAE) consensus motif; other site 246196015230 putative AMP binding site [chemical binding]; other site 246196015231 putative active site [active] 246196015232 putative CoA binding site [chemical binding]; other site 246196015233 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 246196015234 hydrophobic ligand binding site; other site 246196015235 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 246196015236 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 246196015237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196015238 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 246196015239 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 246196015240 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196015241 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 246196015242 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196015243 enoyl-CoA hydratase; Provisional; Region: PRK07854 246196015244 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015245 substrate binding site [chemical binding]; other site 246196015246 oxyanion hole (OAH) forming residues; other site 246196015247 trimer interface [polypeptide binding]; other site 246196015248 N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742 246196015249 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 246196015250 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 246196015251 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 246196015252 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196015253 putative ADP-binding pocket [chemical binding]; other site 246196015254 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 246196015255 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 246196015256 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 246196015257 Predicted membrane protein [Function unknown]; Region: COG1511 246196015258 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 246196015259 putative internal core protein; Provisional; Region: PHA03413 246196015260 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 246196015261 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 246196015262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015263 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 246196015264 Walker A/P-loop; other site 246196015265 ATP binding site [chemical binding]; other site 246196015266 Q-loop/lid; other site 246196015267 ABC transporter signature motif; other site 246196015268 Walker B; other site 246196015269 AMP-binding domain protein; Validated; Region: PRK08315 246196015270 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 246196015271 acyl-activating enzyme (AAE) consensus motif; other site 246196015272 putative AMP binding site [chemical binding]; other site 246196015273 putative active site [active] 246196015274 putative CoA binding site [chemical binding]; other site 246196015275 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 246196015276 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196015277 acyl-activating enzyme (AAE) consensus motif; other site 246196015278 AMP binding site [chemical binding]; other site 246196015279 active site 246196015280 CoA binding site [chemical binding]; other site 246196015281 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196015282 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196015283 DNA binding residues [nucleotide binding] 246196015284 dimerization interface [polypeptide binding]; other site 246196015285 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196015286 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196015287 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 246196015288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196015289 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246196015290 dimerization interface [polypeptide binding]; other site 246196015291 substrate binding pocket [chemical binding]; other site 246196015292 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196015293 Na binding site [ion binding]; other site 246196015294 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 246196015295 putative active site [active] 246196015296 catalytic triad [active] 246196015297 putative dimer interface [polypeptide binding]; other site 246196015298 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 246196015299 histidinol dehydrogenase; Region: hisD; TIGR00069 246196015300 NAD binding site [chemical binding]; other site 246196015301 dimerization interface [polypeptide binding]; other site 246196015302 product binding site; other site 246196015303 substrate binding site [chemical binding]; other site 246196015304 zinc binding site [ion binding]; other site 246196015305 catalytic residues [active] 246196015306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196015307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196015308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196015309 dimerization interface [polypeptide binding]; other site 246196015310 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196015311 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196015312 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196015313 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196015314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015315 Walker A/P-loop; other site 246196015316 ATP binding site [chemical binding]; other site 246196015317 Q-loop/lid; other site 246196015318 ABC transporter signature motif; other site 246196015319 Walker B; other site 246196015320 D-loop; other site 246196015321 H-loop/switch region; other site 246196015322 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196015323 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196015324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015325 Walker A/P-loop; other site 246196015326 ATP binding site [chemical binding]; other site 246196015327 Q-loop/lid; other site 246196015328 ABC transporter signature motif; other site 246196015329 Walker B; other site 246196015330 D-loop; other site 246196015331 H-loop/switch region; other site 246196015332 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196015333 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196015334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015335 Walker A/P-loop; other site 246196015336 ATP binding site [chemical binding]; other site 246196015337 Q-loop/lid; other site 246196015338 ABC transporter signature motif; other site 246196015339 Walker B; other site 246196015340 D-loop; other site 246196015341 H-loop/switch region; other site 246196015342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196015343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196015344 active site 246196015345 phosphorylation site [posttranslational modification] 246196015346 intermolecular recognition site; other site 246196015347 dimerization interface [polypeptide binding]; other site 246196015348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196015349 DNA binding site [nucleotide binding] 246196015350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196015351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196015352 dimerization interface [polypeptide binding]; other site 246196015353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196015354 dimer interface [polypeptide binding]; other site 246196015355 phosphorylation site [posttranslational modification] 246196015356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196015357 ATP binding site [chemical binding]; other site 246196015358 Mg2+ binding site [ion binding]; other site 246196015359 G-X-G motif; other site 246196015360 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246196015361 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 246196015362 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246196015363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196015364 Winged helix-turn helix; Region: HTH_29; pfam13551 246196015365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015366 putative DNA binding site [nucleotide binding]; other site 246196015367 dimerization interface [polypeptide binding]; other site 246196015368 putative Zn2+ binding site [ion binding]; other site 246196015369 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246196015370 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015372 putative DNA binding site [nucleotide binding]; other site 246196015373 putative Zn2+ binding site [ion binding]; other site 246196015374 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196015375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196015377 putative substrate translocation pore; other site 246196015378 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 246196015379 putative deacylase active site [active] 246196015380 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 246196015381 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 246196015382 dimer interface [polypeptide binding]; other site 246196015383 active site 246196015384 citrylCoA binding site [chemical binding]; other site 246196015385 NADH binding [chemical binding]; other site 246196015386 cationic pore residues; other site 246196015387 oxalacetate/citrate binding site [chemical binding]; other site 246196015388 coenzyme A binding site [chemical binding]; other site 246196015389 catalytic triad [active] 246196015390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015392 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196015393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015394 putative substrate translocation pore; other site 246196015395 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 246196015396 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 246196015397 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 246196015398 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 246196015399 citrate synthase 2; Provisional; Region: PRK12350 246196015400 oxalacetate binding site [chemical binding]; other site 246196015401 citrylCoA binding site [chemical binding]; other site 246196015402 coenzyme A binding site [chemical binding]; other site 246196015403 catalytic triad [active] 246196015404 TIGR03086 family protein; Region: TIGR03086 246196015405 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 246196015406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015407 dimerization interface [polypeptide binding]; other site 246196015408 putative DNA binding site [nucleotide binding]; other site 246196015409 putative Zn2+ binding site [ion binding]; other site 246196015410 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 246196015411 putative dimer interface [polypeptide binding]; other site 246196015412 Ferredoxin [Energy production and conversion]; Region: COG1146 246196015413 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 246196015414 4Fe-4S binding domain; Region: Fer4; pfam00037 246196015415 ferredoxin-NADP+ reductase; Region: PLN02852 246196015416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196015417 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 246196015418 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246196015419 active site 246196015420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196015421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196015422 catalytic residue [active] 246196015423 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 246196015424 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 246196015425 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 246196015426 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246196015427 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196015429 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 246196015430 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 246196015431 hydrophobic ligand binding site; other site 246196015432 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 246196015433 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196015434 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 246196015435 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 246196015436 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246196015437 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 246196015438 putative dimer interface [polypeptide binding]; other site 246196015439 N-terminal domain interface [polypeptide binding]; other site 246196015440 putative substrate binding pocket (H-site) [chemical binding]; other site 246196015441 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246196015442 DNA-binding site [nucleotide binding]; DNA binding site 246196015443 RNA-binding motif; other site 246196015444 hypothetical protein; Provisional; Region: PRK11770 246196015445 Domain of unknown function (DUF307); Region: DUF307; pfam03733 246196015446 Domain of unknown function (DUF307); Region: DUF307; pfam03733 246196015447 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 246196015448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246196015449 FeS/SAM binding site; other site 246196015450 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 246196015451 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 246196015452 MoaE interaction surface [polypeptide binding]; other site 246196015453 MoeB interaction surface [polypeptide binding]; other site 246196015454 thiocarboxylated glycine; other site 246196015455 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 246196015456 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 246196015457 MoaE homodimer interface [polypeptide binding]; other site 246196015458 MoaD interaction [polypeptide binding]; other site 246196015459 active site residues [active] 246196015460 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 246196015461 MPT binding site; other site 246196015462 trimer interface [polypeptide binding]; other site 246196015463 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 246196015464 trimer interface [polypeptide binding]; other site 246196015465 dimer interface [polypeptide binding]; other site 246196015466 putative active site [active] 246196015467 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 246196015468 HEXXH motif domain; Region: mod_HExxH; TIGR04267 246196015469 WYL domain; Region: WYL; pfam13280 246196015470 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 246196015471 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 246196015472 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196015473 ATP binding site [chemical binding]; other site 246196015474 putative Mg++ binding site [ion binding]; other site 246196015475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196015476 nucleotide binding region [chemical binding]; other site 246196015477 ATP-binding site [chemical binding]; other site 246196015478 Cupin domain; Region: Cupin_2; cl17218 246196015479 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 246196015480 NifQ; Region: NifQ; pfam04891 246196015481 short chain dehydrogenase; Validated; Region: PRK08264 246196015482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015483 NAD(P) binding site [chemical binding]; other site 246196015484 active site 246196015485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196015486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196015487 putative substrate translocation pore; other site 246196015488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196015489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196015490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196015491 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196015492 classical (c) SDRs; Region: SDR_c; cd05233 246196015493 NAD(P) binding site [chemical binding]; other site 246196015494 active site 246196015495 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 246196015496 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196015497 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 246196015498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015500 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196015501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196015502 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 246196015503 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015504 substrate binding site [chemical binding]; other site 246196015505 oxyanion hole (OAH) forming residues; other site 246196015506 trimer interface [polypeptide binding]; other site 246196015507 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196015508 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196015509 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 246196015510 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196015511 dimer interface [polypeptide binding]; other site 246196015512 active site 246196015513 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 246196015514 homotrimer interaction site [polypeptide binding]; other site 246196015515 putative active site [active] 246196015516 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196015518 aminotransferase; Validated; Region: PRK07777 246196015519 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196015520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196015521 homodimer interface [polypeptide binding]; other site 246196015522 catalytic residue [active] 246196015523 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 246196015524 allantoicase; Provisional; Region: PRK13257 246196015525 Allantoicase repeat; Region: Allantoicase; pfam03561 246196015526 Allantoicase repeat; Region: Allantoicase; pfam03561 246196015527 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 246196015528 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 246196015529 active site 246196015530 catalytic site [active] 246196015531 tetramer interface [polypeptide binding]; other site 246196015532 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246196015533 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 246196015534 Na binding site [ion binding]; other site 246196015535 putative substrate binding site [chemical binding]; other site 246196015536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196015537 DNA-binding site [nucleotide binding]; DNA binding site 246196015538 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 246196015539 FCD domain; Region: FCD; pfam07729 246196015540 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196015541 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196015542 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196015543 Ligand Binding Site [chemical binding]; other site 246196015544 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246196015545 Ligand Binding Site [chemical binding]; other site 246196015546 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196015547 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 246196015548 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 246196015549 dimer interface [polypeptide binding]; other site 246196015550 PYR/PP interface [polypeptide binding]; other site 246196015551 TPP binding site [chemical binding]; other site 246196015552 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196015553 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 246196015554 TPP-binding site [chemical binding]; other site 246196015555 dimer interface [polypeptide binding]; other site 246196015556 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 246196015557 putative hydrophobic ligand binding site [chemical binding]; other site 246196015558 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 246196015559 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246196015560 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196015561 acyl-activating enzyme (AAE) consensus motif; other site 246196015562 AMP binding site [chemical binding]; other site 246196015563 active site 246196015564 CoA binding site [chemical binding]; other site 246196015565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196015566 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 246196015567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015568 NAD(P) binding site [chemical binding]; other site 246196015569 active site 246196015570 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 246196015571 putative active site [active] 246196015572 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 246196015573 putative acyl-acceptor binding pocket; other site 246196015574 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 246196015575 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 246196015576 nucleophile elbow; other site 246196015577 Gas vesicle protein K; Region: GvpK; pfam05121 246196015578 Gas vesicle protein; Region: Gas_vesicle; pfam00741 246196015579 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 246196015580 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 246196015581 putative active site [active] 246196015582 putative metal binding site [ion binding]; other site 246196015583 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 246196015584 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 246196015585 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 246196015586 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; cl17873 246196015587 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 246196015588 Int/Topo IB signature motif; other site 246196015589 PE-PPE domain; Region: PE-PPE; pfam08237 246196015590 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196015591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196015592 DNA-binding site [nucleotide binding]; DNA binding site 246196015593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196015594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196015595 homodimer interface [polypeptide binding]; other site 246196015596 catalytic residue [active] 246196015597 Cupin domain; Region: Cupin_2; cl17218 246196015598 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196015599 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196015600 putative NAD(P) binding site [chemical binding]; other site 246196015601 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196015602 Probable pheophorbidase; Region: PLN02965; cl17657 246196015603 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 246196015604 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 246196015605 apolar tunnel; other site 246196015606 heme binding site [chemical binding]; other site 246196015607 dimerization interface [polypeptide binding]; other site 246196015608 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196015609 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 246196015610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015611 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 246196015612 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 246196015613 homodimer interface [polypeptide binding]; other site 246196015614 putative substrate binding pocket [chemical binding]; other site 246196015615 diiron center [ion binding]; other site 246196015616 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 246196015617 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 246196015618 FMN binding site [chemical binding]; other site 246196015619 active site 246196015620 catalytic residues [active] 246196015621 substrate binding site [chemical binding]; other site 246196015622 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 246196015623 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 246196015624 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 246196015625 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 246196015626 PhoU domain; Region: PhoU; pfam01895 246196015627 PhoU domain; Region: PhoU; pfam01895 246196015628 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196015629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196015630 dimerization interface [polypeptide binding]; other site 246196015631 putative Zn2+ binding site [ion binding]; other site 246196015632 putative DNA binding site [nucleotide binding]; other site 246196015633 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196015634 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196015635 NAD(P) binding site [chemical binding]; other site 246196015636 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 246196015637 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 246196015638 Walker A/P-loop; other site 246196015639 ATP binding site [chemical binding]; other site 246196015640 Q-loop/lid; other site 246196015641 ABC transporter signature motif; other site 246196015642 Walker B; other site 246196015643 D-loop; other site 246196015644 H-loop/switch region; other site 246196015645 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 246196015646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015647 dimer interface [polypeptide binding]; other site 246196015648 conserved gate region; other site 246196015649 putative PBP binding loops; other site 246196015650 ABC-ATPase subunit interface; other site 246196015651 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 246196015652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015653 dimer interface [polypeptide binding]; other site 246196015654 conserved gate region; other site 246196015655 putative PBP binding loops; other site 246196015656 ABC-ATPase subunit interface; other site 246196015657 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196015658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196015659 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196015660 DNA binding site [nucleotide binding] 246196015661 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 246196015662 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246196015663 catalytic residues [active] 246196015664 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 246196015665 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 246196015666 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 246196015667 active site residue [active] 246196015668 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 246196015669 active site residue [active] 246196015670 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 246196015671 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 246196015672 heme-binding site [chemical binding]; other site 246196015673 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 246196015674 homodimer interface [polypeptide binding]; other site 246196015675 substrate-cofactor binding pocket; other site 246196015676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196015677 catalytic residue [active] 246196015678 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 246196015679 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 246196015680 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 246196015681 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 246196015682 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 246196015683 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 246196015684 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 246196015685 dimerization interface [polypeptide binding]; other site 246196015686 putative ATP binding site [chemical binding]; other site 246196015687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015688 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246196015689 NAD(P) binding site [chemical binding]; other site 246196015690 active site 246196015691 amidophosphoribosyltransferase; Provisional; Region: PRK07847 246196015692 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 246196015693 active site 246196015694 tetramer interface [polypeptide binding]; other site 246196015695 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196015696 active site 246196015697 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196015698 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196015699 short chain dehydrogenase; Provisional; Region: PRK06500 246196015700 classical (c) SDRs; Region: SDR_c; cd05233 246196015701 NAD(P) binding site [chemical binding]; other site 246196015702 active site 246196015703 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 246196015704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196015705 Walker A/P-loop; other site 246196015706 ATP binding site [chemical binding]; other site 246196015707 Q-loop/lid; other site 246196015708 ABC transporter signature motif; other site 246196015709 Walker B; other site 246196015710 D-loop; other site 246196015711 H-loop/switch region; other site 246196015712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196015713 dimer interface [polypeptide binding]; other site 246196015714 conserved gate region; other site 246196015715 putative PBP binding loops; other site 246196015716 ABC-ATPase subunit interface; other site 246196015717 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 246196015718 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196015719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015721 short chain dehydrogenase; Provisional; Region: PRK12827 246196015722 classical (c) SDRs; Region: SDR_c; cd05233 246196015723 NAD(P) binding site [chemical binding]; other site 246196015724 active site 246196015725 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196015726 classical (c) SDRs; Region: SDR_c; cd05233 246196015727 NAD(P) binding site [chemical binding]; other site 246196015728 active site 246196015729 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246196015730 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 246196015731 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196015732 NAD(P) binding site [chemical binding]; other site 246196015733 catalytic residues [active] 246196015734 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196015735 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196015736 mce related protein; Region: MCE; pfam02470 246196015737 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196015738 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 246196015739 CAAX protease self-immunity; Region: Abi; pfam02517 246196015740 Predicted membrane protein [Function unknown]; Region: COG4425 246196015741 Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420 246196015742 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 246196015743 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 246196015744 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 246196015745 dimerization interface [polypeptide binding]; other site 246196015746 ATP binding site [chemical binding]; other site 246196015747 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 246196015748 dimerization interface [polypeptide binding]; other site 246196015749 ATP binding site [chemical binding]; other site 246196015750 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 246196015751 thiamine pyrophosphate protein; Provisional; Region: PRK08273 246196015752 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246196015753 PYR/PP interface [polypeptide binding]; other site 246196015754 dimer interface [polypeptide binding]; other site 246196015755 tetramer interface [polypeptide binding]; other site 246196015756 TPP binding site [chemical binding]; other site 246196015757 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246196015758 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 246196015759 TPP-binding site [chemical binding]; other site 246196015760 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196015761 active site 246196015762 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 246196015763 active site 246196015764 metal binding site [ion binding]; metal-binding site 246196015765 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 246196015766 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 246196015767 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 246196015768 putative active site [active] 246196015769 catalytic triad [active] 246196015770 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 246196015771 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 246196015772 Predicted oxidoreductase [General function prediction only]; Region: COG3573 246196015773 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196015774 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 246196015775 putative active site [active] 246196015776 putative Zn binding site [ion binding]; other site 246196015777 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 246196015778 catalytic residues [active] 246196015779 dimer interface [polypeptide binding]; other site 246196015780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015782 WHG domain; Region: WHG; pfam13305 246196015783 Predicted membrane protein [Function unknown]; Region: COG4270 246196015784 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 246196015785 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246196015786 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 246196015787 ATP binding site [chemical binding]; other site 246196015788 active site 246196015789 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 246196015790 substrate binding site [chemical binding]; other site 246196015791 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 246196015792 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246196015793 putative active site [active] 246196015794 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196015795 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 246196015796 gating phenylalanine in ion channel; other site 246196015797 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196015798 adenylosuccinate lyase; Region: purB; TIGR00928 246196015799 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 246196015800 tetramer interface [polypeptide binding]; other site 246196015801 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 246196015802 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 246196015803 synthetase active site [active] 246196015804 NTP binding site [chemical binding]; other site 246196015805 metal binding site [ion binding]; metal-binding site 246196015806 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246196015807 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196015808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 246196015809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015810 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196015811 Putative esterase; Region: Esterase; pfam00756 246196015812 S-formylglutathione hydrolase; Region: PLN02442 246196015813 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 246196015814 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 246196015815 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 246196015816 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 246196015817 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196015818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196015820 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 246196015821 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196015822 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196015823 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196015824 short chain dehydrogenase; Provisional; Region: PRK07774 246196015825 classical (c) SDRs; Region: SDR_c; cd05233 246196015826 NAD(P) binding site [chemical binding]; other site 246196015827 active site 246196015828 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 246196015829 NAD binding site [chemical binding]; other site 246196015830 catalytic residues [active] 246196015831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196015832 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196015833 short chain dehydrogenase; Provisional; Region: PRK07775 246196015834 classical (c) SDRs; Region: SDR_c; cd05233 246196015835 NAD(P) binding site [chemical binding]; other site 246196015836 active site 246196015837 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196015838 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 246196015839 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196015840 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 246196015841 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 246196015842 NAD binding site [chemical binding]; other site 246196015843 catalytic Zn binding site [ion binding]; other site 246196015844 substrate binding site [chemical binding]; other site 246196015845 structural Zn binding site [ion binding]; other site 246196015846 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196015847 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196015848 classical (c) SDRs; Region: SDR_c; cd05233 246196015849 NAD(P) binding site [chemical binding]; other site 246196015850 active site 246196015851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015852 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 246196015853 nucleotide binding site/active site [active] 246196015854 HIT family signature motif; other site 246196015855 catalytic residue [active] 246196015856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196015857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196015858 dimerization interface [polypeptide binding]; other site 246196015859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196015860 dimer interface [polypeptide binding]; other site 246196015861 phosphorylation site [posttranslational modification] 246196015862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196015863 ATP binding site [chemical binding]; other site 246196015864 Mg2+ binding site [ion binding]; other site 246196015865 G-X-G motif; other site 246196015866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246196015867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196015868 active site 246196015869 phosphorylation site [posttranslational modification] 246196015870 intermolecular recognition site; other site 246196015871 dimerization interface [polypeptide binding]; other site 246196015872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246196015873 DNA binding site [nucleotide binding] 246196015874 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196015875 active site 246196015876 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 246196015877 Cutinase; Region: Cutinase; pfam01083 246196015878 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 246196015879 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246196015880 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246196015881 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246196015882 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 246196015883 putative hydrophobic ligand binding site [chemical binding]; other site 246196015884 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246196015885 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 246196015886 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 246196015887 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246196015888 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196015889 catalytic loop [active] 246196015890 iron binding site [ion binding]; other site 246196015891 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246196015892 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196015893 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 246196015894 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 246196015895 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 246196015896 classical (c) SDRs; Region: SDR_c; cd05233 246196015897 NAD(P) binding site [chemical binding]; other site 246196015898 active site 246196015899 enoyl-CoA hydratase; Provisional; Region: PRK08290 246196015900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015901 substrate binding site [chemical binding]; other site 246196015902 oxyanion hole (OAH) forming residues; other site 246196015903 trimer interface [polypeptide binding]; other site 246196015904 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 246196015905 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 246196015906 active site 246196015907 homotetramer interface [polypeptide binding]; other site 246196015908 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196015909 Winged helix-turn helix; Region: HTH_29; pfam13551 246196015910 Homeodomain-like domain; Region: HTH_32; pfam13565 246196015911 DDE superfamily endonuclease; Region: DDE_3; cl19249 246196015912 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196015913 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196015914 mce related protein; Region: MCE; pfam02470 246196015915 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196015916 mce related protein; Region: MCE; pfam02470 246196015917 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196015918 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196015919 mce related protein; Region: MCE; pfam02470 246196015920 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196015921 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196015922 mce related protein; Region: MCE; pfam02470 246196015923 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196015924 mce related protein; Region: MCE; pfam02470 246196015925 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246196015926 mce related protein; Region: MCE; pfam02470 246196015927 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196015928 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196015929 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246196015930 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 246196015931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015932 NAD(P) binding site [chemical binding]; other site 246196015933 active site 246196015934 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 246196015935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196015936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196015937 active site 246196015938 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196015939 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196015940 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196015941 active site 246196015942 acyl-CoA synthetase; Validated; Region: PRK07867 246196015943 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 246196015944 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196015945 acyl-activating enzyme (AAE) consensus motif; other site 246196015946 acyl-activating enzyme (AAE) consensus motif; other site 246196015947 putative AMP binding site [chemical binding]; other site 246196015948 putative active site [active] 246196015949 putative CoA binding site [chemical binding]; other site 246196015950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196015951 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 246196015952 NAD(P) binding site [chemical binding]; other site 246196015953 active site 246196015954 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246196015955 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 246196015956 dimer interface [polypeptide binding]; other site 246196015957 ligand binding site [chemical binding]; other site 246196015958 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 246196015959 NAD(P) binding site [chemical binding]; other site 246196015960 catalytic residues [active] 246196015961 Nitronate monooxygenase; Region: NMO; pfam03060 246196015962 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196015963 FMN binding site [chemical binding]; other site 246196015964 substrate binding site [chemical binding]; other site 246196015965 putative catalytic residue [active] 246196015966 acyl-CoA synthetase; Validated; Region: PRK07798 246196015967 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196015968 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 246196015969 acyl-activating enzyme (AAE) consensus motif; other site 246196015970 acyl-activating enzyme (AAE) consensus motif; other site 246196015971 putative AMP binding site [chemical binding]; other site 246196015972 putative active site [active] 246196015973 putative CoA binding site [chemical binding]; other site 246196015974 enoyl-CoA hydratase; Provisional; Region: PRK07799 246196015975 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196015976 substrate binding site [chemical binding]; other site 246196015977 oxyanion hole (OAH) forming residues; other site 246196015978 trimer interface [polypeptide binding]; other site 246196015979 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 246196015980 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196015981 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 246196015982 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196015983 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196015984 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196015985 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 246196015986 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196015987 lipid-transfer protein; Provisional; Region: PRK07937 246196015988 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246196015989 active site 246196015990 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 246196015991 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196015992 active site 246196015993 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246196015994 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 246196015995 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246196015996 hydrophobic ligand binding site; other site 246196015997 CotH protein; Region: CotH; cl19892 246196015998 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 246196015999 putative metal binding residues [ion binding]; other site 246196016000 signature motif; other site 246196016001 dimer interface [polypeptide binding]; other site 246196016002 active site 246196016003 polyP binding site; other site 246196016004 substrate binding site [chemical binding]; other site 246196016005 acceptor-phosphate pocket; other site 246196016006 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 246196016007 short chain dehydrogenase; Provisional; Region: PRK07890 246196016008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016009 NAD(P) binding site [chemical binding]; other site 246196016010 active site 246196016011 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 246196016012 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196016013 active site 246196016014 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196016015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196016016 putative DNA binding site [nucleotide binding]; other site 246196016017 putative Zn2+ binding site [ion binding]; other site 246196016018 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 246196016019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196016020 ATP binding site [chemical binding]; other site 246196016021 putative Mg++ binding site [ion binding]; other site 246196016022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196016023 nucleotide binding region [chemical binding]; other site 246196016024 ATP-binding site [chemical binding]; other site 246196016025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196016026 active site 246196016027 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 246196016028 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 246196016029 active site 246196016030 catalytic residues [active] 246196016031 metal binding site [ion binding]; metal-binding site 246196016032 DmpG-like communication domain; Region: DmpG_comm; pfam07836 246196016033 acetaldehyde dehydrogenase; Validated; Region: PRK08300 246196016034 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 246196016035 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 246196016036 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 246196016037 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 246196016038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196016039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196016040 enoyl-CoA hydratase; Region: PLN02864 246196016041 N-terminal half of MaoC dehydratase; Region: MaoC_dehydrat_N; pfam13452 246196016042 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 246196016043 dimer interaction site [polypeptide binding]; other site 246196016044 substrate-binding tunnel; other site 246196016045 active site 246196016046 catalytic site [active] 246196016047 substrate binding site [chemical binding]; other site 246196016048 AMP-binding enzyme; Region: AMP-binding; pfam00501 246196016049 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196016050 acyl-activating enzyme (AAE) consensus motif; other site 246196016051 AMP binding site [chemical binding]; other site 246196016052 active site 246196016053 CoA binding site [chemical binding]; other site 246196016054 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196016055 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246196016056 Geminivirus putative movement protein; Region: Gemini_mov; pfam01708 246196016057 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246196016058 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196016059 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196016060 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196016061 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 246196016062 putative active site [active] 246196016063 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246196016064 putative trimer interface [polypeptide binding]; other site 246196016065 putative CoA binding site [chemical binding]; other site 246196016066 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; cl10513 246196016067 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246196016068 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246196016069 active site 246196016070 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 246196016071 putative trimer interface [polypeptide binding]; other site 246196016072 putative active site [active] 246196016073 putative substrate binding site [chemical binding]; other site 246196016074 putative CoA binding site [chemical binding]; other site 246196016075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196016076 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 246196016077 putative ADP-binding pocket [chemical binding]; other site 246196016078 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 246196016079 active site 246196016080 catalytic triad [active] 246196016081 oxyanion hole [active] 246196016082 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 246196016083 active site 246196016084 catalytic triad [active] 246196016085 oxyanion hole [active] 246196016086 Chain length determinant protein; Region: Wzz; pfam02706 246196016087 Chain length determinant protein; Region: Wzz; pfam02706 246196016088 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196016089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016090 NAD(P) binding site [chemical binding]; other site 246196016091 active site 246196016092 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 246196016093 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 246196016094 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246196016095 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246196016096 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 246196016097 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 246196016098 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 246196016099 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246196016100 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196016101 active site 246196016102 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 246196016103 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246196016104 putative active site [active] 246196016105 putative metal binding site [ion binding]; other site 246196016106 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196016107 active site 246196016108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 246196016109 putative glycosyl transferase; Provisional; Region: PRK10307 246196016110 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 246196016111 classical (c) SDRs; Region: SDR_c; cd05233 246196016112 NAD(P) binding site [chemical binding]; other site 246196016113 active site 246196016114 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246196016115 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246196016116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196016117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196016118 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246196016119 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 246196016120 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 246196016121 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196016122 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 246196016123 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196016124 catalytic residue [active] 246196016125 Protein of unknown function (DUF4532); Region: DUF4532; pfam15046 246196016126 adenylosuccinate lyase; Provisional; Region: PRK08470 246196016127 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 246196016128 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196016129 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 246196016130 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 246196016131 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196016132 extended (e) SDRs; Region: SDR_e; cd08946 246196016133 NAD(P) binding site [chemical binding]; other site 246196016134 active site 246196016135 substrate binding site [chemical binding]; other site 246196016136 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 246196016137 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 246196016138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196016139 active site 246196016140 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 246196016141 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246196016142 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 246196016143 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 246196016144 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 246196016145 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 246196016146 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 246196016147 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246196016148 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246196016149 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 246196016150 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 246196016151 substrate binding site; other site 246196016152 tetramer interface; other site 246196016153 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 246196016154 CoA binding domain; Region: CoA_binding; cl17356 246196016155 Bacterial sugar transferase; Region: Bac_transf; pfam02397 246196016156 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196016157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016158 NAD(P) binding site [chemical binding]; other site 246196016159 active site 246196016160 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246196016161 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246196016162 glutaminase active site [active] 246196016163 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246196016164 dimer interface [polypeptide binding]; other site 246196016165 active site 246196016166 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246196016167 dimer interface [polypeptide binding]; other site 246196016168 active site 246196016169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196016170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196016171 active site 246196016172 phosphorylation site [posttranslational modification] 246196016173 intermolecular recognition site; other site 246196016174 dimerization interface [polypeptide binding]; other site 246196016175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196016176 DNA binding residues [nucleotide binding] 246196016177 dimerization interface [polypeptide binding]; other site 246196016178 lipid-transfer protein; Provisional; Region: PRK07855 246196016179 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196016180 active site 246196016181 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 246196016182 putative active site [active] 246196016183 putative catalytic site [active] 246196016184 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196016185 active site 246196016186 catalytic site [active] 246196016187 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 246196016188 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196016189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016190 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016191 active site 246196016192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016193 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196016194 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016195 active site 246196016196 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196016197 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 246196016198 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196016199 dimer interface [polypeptide binding]; other site 246196016200 active site 246196016201 Domain of unknown function (DUF385); Region: DUF385; pfam04075 246196016202 short chain dehydrogenase; Provisional; Region: PRK07791 246196016203 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 246196016204 homodimer interface [polypeptide binding]; other site 246196016205 NAD binding site [chemical binding]; other site 246196016206 active site 246196016207 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196016208 classical (c) SDRs; Region: SDR_c; cd05233 246196016209 NAD(P) binding site [chemical binding]; other site 246196016210 active site 246196016211 enoyl-CoA hydratase; Provisional; Region: PRK07938 246196016212 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196016213 substrate binding site [chemical binding]; other site 246196016214 oxyanion hole (OAH) forming residues; other site 246196016215 trimer interface [polypeptide binding]; other site 246196016216 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 246196016217 Coenzyme A transferase; Region: CoA_trans; cl17247 246196016218 Nitronate monooxygenase; Region: NMO; pfam03060 246196016219 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246196016220 FMN binding site [chemical binding]; other site 246196016221 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 246196016222 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246196016223 dimer interface [polypeptide binding]; other site 246196016224 active site 246196016225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196016227 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 246196016228 short chain dehydrogenase; Provisional; Region: PRK07831 246196016229 classical (c) SDRs; Region: SDR_c; cd05233 246196016230 NAD(P) binding site [chemical binding]; other site 246196016231 active site 246196016232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016234 active site 246196016235 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016236 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016237 active site 246196016238 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016239 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 246196016240 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016241 active site 246196016242 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016244 aspartate aminotransferase; Provisional; Region: PRK05764 246196016245 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196016246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196016247 homodimer interface [polypeptide binding]; other site 246196016248 catalytic residue [active] 246196016249 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196016250 TM-ABC transporter signature motif; other site 246196016251 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196016252 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196016253 Walker A/P-loop; other site 246196016254 ATP binding site [chemical binding]; other site 246196016255 Q-loop/lid; other site 246196016256 ABC transporter signature motif; other site 246196016257 Walker B; other site 246196016258 D-loop; other site 246196016259 H-loop/switch region; other site 246196016260 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 246196016261 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 246196016262 putative ligand binding site [chemical binding]; other site 246196016263 xylose isomerase; Provisional; Region: PRK12677 246196016264 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196016265 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196016266 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196016267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246196016268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196016269 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246196016270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246196016271 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246196016272 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196016273 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196016274 active site 246196016275 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 246196016276 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 246196016277 acyl-activating enzyme (AAE) consensus motif; other site 246196016278 putative AMP binding site [chemical binding]; other site 246196016279 putative active site [active] 246196016280 putative CoA binding site [chemical binding]; other site 246196016281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016282 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 246196016283 NAD(P) binding site [chemical binding]; other site 246196016284 active site 246196016285 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196016286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196016287 putative substrate translocation pore; other site 246196016288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196016289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196016290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196016291 dimerization interface [polypeptide binding]; other site 246196016292 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246196016293 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246196016294 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196016295 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196016296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016297 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 246196016298 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 246196016299 classical (c) SDRs; Region: SDR_c; cd05233 246196016300 NAD(P) binding site [chemical binding]; other site 246196016301 active site 246196016302 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 246196016303 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 246196016304 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 246196016305 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 246196016306 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 246196016307 active site 246196016308 Fe binding site [ion binding]; other site 246196016309 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 246196016310 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196016311 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016312 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 246196016313 Flavin binding site [chemical binding]; other site 246196016314 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 246196016315 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 246196016316 FAD binding pocket [chemical binding]; other site 246196016317 FAD binding motif [chemical binding]; other site 246196016318 phosphate binding motif [ion binding]; other site 246196016319 beta-alpha-beta structure motif; other site 246196016320 NAD(p) ribose binding residues [chemical binding]; other site 246196016321 NAD binding pocket [chemical binding]; other site 246196016322 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 246196016323 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196016324 catalytic loop [active] 246196016325 iron binding site [ion binding]; other site 246196016326 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016327 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 246196016328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016329 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196016330 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196016331 active site 246196016332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196016334 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 246196016335 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 246196016336 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196016337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196016338 DNA binding site [nucleotide binding] 246196016339 domain linker motif; other site 246196016340 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 246196016341 putative dimerization interface [polypeptide binding]; other site 246196016342 putative ligand binding site [chemical binding]; other site 246196016343 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 246196016344 ABC-ATPase subunit interface; other site 246196016345 dimer interface [polypeptide binding]; other site 246196016346 putative PBP binding regions; other site 246196016347 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196016348 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 246196016349 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 246196016350 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246196016351 intersubunit interface [polypeptide binding]; other site 246196016352 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 246196016353 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 246196016354 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 246196016355 PQQ-like domain; Region: PQQ_2; pfam13360 246196016356 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 246196016357 Periplasmic solute binding protein family; Region: TroA; pfam01297 246196016358 intersubunit interface [polypeptide binding]; other site 246196016359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196016360 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 246196016361 Walker A/P-loop; other site 246196016362 ATP binding site [chemical binding]; other site 246196016363 ABC transporter signature motif; other site 246196016364 Walker B; other site 246196016365 D-loop; other site 246196016366 H-loop/switch region; other site 246196016367 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 246196016368 putative FMN binding site [chemical binding]; other site 246196016369 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 246196016370 putative active site [active] 246196016371 MspA; Region: MspA; pfam09203 246196016372 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246196016373 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246196016374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196016375 motif II; other site 246196016376 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 246196016377 Predicted permease; Region: DUF318; cl17795 246196016378 TIGR03943 family protein; Region: TIGR03943 246196016379 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246196016380 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246196016381 Walker A/P-loop; other site 246196016382 ATP binding site [chemical binding]; other site 246196016383 Q-loop/lid; other site 246196016384 ABC transporter signature motif; other site 246196016385 Walker B; other site 246196016386 D-loop; other site 246196016387 H-loop/switch region; other site 246196016388 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246196016389 ABC-ATPase subunit interface; other site 246196016390 dimer interface [polypeptide binding]; other site 246196016391 putative PBP binding regions; other site 246196016392 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 246196016393 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 246196016394 putative ligand binding residues [chemical binding]; other site 246196016395 30S ribosomal protein S18; Provisional; Region: PRK13401 246196016396 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 246196016397 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 246196016398 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 246196016399 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 246196016400 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 246196016401 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 246196016402 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196016403 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246196016404 transmembrane helices; other site 246196016405 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 246196016406 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 246196016407 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246196016408 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 246196016409 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246196016410 active site 246196016411 HIGH motif; other site 246196016412 KMSKS motif; other site 246196016413 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 246196016414 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 246196016415 homotrimer interaction site [polypeptide binding]; other site 246196016416 zinc binding site [ion binding]; other site 246196016417 CDP-binding sites; other site 246196016418 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 246196016419 substrate binding site; other site 246196016420 dimer interface; other site 246196016421 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 246196016422 DNA repair protein RadA; Provisional; Region: PRK11823 246196016423 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246196016424 Walker A motif; other site 246196016425 ATP binding site [chemical binding]; other site 246196016426 Walker B motif; other site 246196016427 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 246196016428 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 246196016429 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 246196016430 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 246196016431 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 246196016432 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 246196016433 active site clefts [active] 246196016434 zinc binding site [ion binding]; other site 246196016435 dimer interface [polypeptide binding]; other site 246196016436 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 246196016437 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246196016438 minor groove reading motif; other site 246196016439 helix-hairpin-helix signature motif; other site 246196016440 substrate binding pocket [chemical binding]; other site 246196016441 active site 246196016442 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 246196016443 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196016444 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196016445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196016446 catalytic site [active] 246196016447 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 246196016448 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 246196016449 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 246196016450 Domain of unknown function (DUF1875); Region: DUF1875; pfam08961 246196016451 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196016452 catalytic core [active] 246196016453 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 246196016454 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 246196016455 Clp protease ATP binding subunit; Region: clpC; CHL00095 246196016456 Clp amino terminal domain; Region: Clp_N; pfam02861 246196016457 Clp amino terminal domain; Region: Clp_N; pfam02861 246196016458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016459 Walker A motif; other site 246196016460 ATP binding site [chemical binding]; other site 246196016461 Walker B motif; other site 246196016462 arginine finger; other site 246196016463 UvrB/uvrC motif; Region: UVR; pfam02151 246196016464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016465 Walker A motif; other site 246196016466 ATP binding site [chemical binding]; other site 246196016467 Walker B motif; other site 246196016468 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246196016469 Lsr2; Region: Lsr2; pfam11774 246196016470 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 246196016471 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 246196016472 dimer interface [polypeptide binding]; other site 246196016473 putative anticodon binding site; other site 246196016474 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246196016475 motif 1; other site 246196016476 dimer interface [polypeptide binding]; other site 246196016477 active site 246196016478 motif 2; other site 246196016479 motif 3; other site 246196016480 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 246196016481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 246196016482 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196016483 catalytic residue [active] 246196016484 pantothenate kinase; Reviewed; Region: PRK13318 246196016485 Pantoate-beta-alanine ligase; Region: PanC; cd00560 246196016486 active site 246196016487 ATP-binding site [chemical binding]; other site 246196016488 pantoate-binding site; other site 246196016489 HXXH motif; other site 246196016490 Uncharacterized conserved protein [Function unknown]; Region: COG5495 246196016491 Rossmann-like domain; Region: Rossmann-like; pfam10727 246196016492 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 246196016493 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 246196016494 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 246196016495 catalytic center binding site [active] 246196016496 ATP binding site [chemical binding]; other site 246196016497 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 246196016498 homooctamer interface [polypeptide binding]; other site 246196016499 active site 246196016500 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 246196016501 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 246196016502 substrate binding pocket [chemical binding]; other site 246196016503 dimer interface [polypeptide binding]; other site 246196016504 inhibitor binding site; inhibition site 246196016505 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 246196016506 active site 246196016507 FtsH Extracellular; Region: FtsH_ext; pfam06480 246196016508 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 246196016509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016510 Walker A motif; other site 246196016511 ATP binding site [chemical binding]; other site 246196016512 Walker B motif; other site 246196016513 arginine finger; other site 246196016514 Peptidase family M41; Region: Peptidase_M41; pfam01434 246196016515 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196016516 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196016517 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196016518 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 246196016519 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196016520 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 246196016521 putative NAD(P) binding site [chemical binding]; other site 246196016522 catalytic Zn binding site [ion binding]; other site 246196016523 Protein of unknown function (DUF541); Region: SIMPL; cl01077 246196016524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196016525 active site 246196016526 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 246196016527 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 246196016528 Ligand Binding Site [chemical binding]; other site 246196016529 TilS substrate binding domain; Region: TilS; pfam09179 246196016530 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 246196016531 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 246196016532 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 246196016533 dimer interface [polypeptide binding]; other site 246196016534 substrate binding site [chemical binding]; other site 246196016535 metal binding sites [ion binding]; metal-binding site 246196016536 putative OHCU decarboxylase; Provisional; Region: PRK13798 246196016537 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 246196016538 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 246196016539 putative ligand binding site [chemical binding]; other site 246196016540 NAD binding site [chemical binding]; other site 246196016541 dimer interface [polypeptide binding]; other site 246196016542 putative catalytic site [active] 246196016543 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 246196016544 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 246196016545 active site 246196016546 tetramer interface [polypeptide binding]; other site 246196016547 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196016548 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196016549 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196016550 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246196016551 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 246196016552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196016553 Walker A/P-loop; other site 246196016554 ATP binding site [chemical binding]; other site 246196016555 Q-loop/lid; other site 246196016556 ABC transporter signature motif; other site 246196016557 Walker B; other site 246196016558 D-loop; other site 246196016559 H-loop/switch region; other site 246196016560 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196016561 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 246196016562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246196016563 Walker A/P-loop; other site 246196016564 ATP binding site [chemical binding]; other site 246196016565 Q-loop/lid; other site 246196016566 ABC transporter signature motif; other site 246196016567 Walker B; other site 246196016568 D-loop; other site 246196016569 H-loop/switch region; other site 246196016570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246196016571 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196016572 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 246196016573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196016574 dimer interface [polypeptide binding]; other site 246196016575 conserved gate region; other site 246196016576 putative PBP binding loops; other site 246196016577 ABC-ATPase subunit interface; other site 246196016578 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196016579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196016580 dimer interface [polypeptide binding]; other site 246196016581 conserved gate region; other site 246196016582 putative PBP binding loops; other site 246196016583 ABC-ATPase subunit interface; other site 246196016584 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196016585 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 246196016586 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 246196016587 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 246196016588 putative ligand binding site [chemical binding]; other site 246196016589 NAD binding site [chemical binding]; other site 246196016590 catalytic site [active] 246196016591 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 246196016592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196016593 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 246196016594 putative dimerization interface [polypeptide binding]; other site 246196016595 putative substrate binding pocket [chemical binding]; other site 246196016596 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246196016597 anti sigma factor interaction site; other site 246196016598 regulatory phosphorylation site [posttranslational modification]; other site 246196016599 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246196016600 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196016601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196016602 active site 246196016603 phosphorylation site [posttranslational modification] 246196016604 intermolecular recognition site; other site 246196016605 dimerization interface [polypeptide binding]; other site 246196016606 CHASE3 domain; Region: CHASE3; pfam05227 246196016607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246196016608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196016609 dimerization interface [polypeptide binding]; other site 246196016610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246196016611 dimer interface [polypeptide binding]; other site 246196016612 phosphorylation site [posttranslational modification] 246196016613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196016614 ATP binding site [chemical binding]; other site 246196016615 Mg2+ binding site [ion binding]; other site 246196016616 G-X-G motif; other site 246196016617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196016618 active site 246196016619 phosphorylation site [posttranslational modification] 246196016620 intermolecular recognition site; other site 246196016621 dimerization interface [polypeptide binding]; other site 246196016622 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 246196016623 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 246196016624 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 246196016625 active site 246196016626 tetramer interface [polypeptide binding]; other site 246196016627 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 246196016628 catalytic residue [active] 246196016629 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 246196016630 dimer interface [polypeptide binding]; other site 246196016631 NADP binding site [chemical binding]; other site 246196016632 catalytic residues [active] 246196016633 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 246196016634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246196016635 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246196016636 acyl-activating enzyme (AAE) consensus motif; other site 246196016637 AMP binding site [chemical binding]; other site 246196016638 active site 246196016639 CoA binding site [chemical binding]; other site 246196016640 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196016641 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 246196016642 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246196016643 putative trimer interface [polypeptide binding]; other site 246196016644 putative CoA binding site [chemical binding]; other site 246196016645 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246196016646 putative trimer interface [polypeptide binding]; other site 246196016647 putative CoA binding site [chemical binding]; other site 246196016648 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 246196016649 Zn binding site [ion binding]; other site 246196016650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196016652 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246196016653 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196016654 active site 246196016655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196016656 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246196016657 NAD(P) binding site [chemical binding]; other site 246196016658 active site 246196016659 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 246196016660 PE-PPE domain; Region: PE-PPE; pfam08237 246196016661 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196016662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 246196016663 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196016664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196016665 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196016666 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196016667 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246196016668 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196016669 DNA polymerase III subunit delta'; Validated; Region: PRK07940 246196016670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016671 Walker A motif; other site 246196016672 ATP binding site [chemical binding]; other site 246196016673 Walker B motif; other site 246196016674 arginine finger; other site 246196016675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246196016676 dimerization interface [polypeptide binding]; other site 246196016677 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246196016678 cyclase homology domain; Region: CHD; cd07302 246196016679 nucleotidyl binding site; other site 246196016680 metal binding site [ion binding]; metal-binding site 246196016681 dimer interface [polypeptide binding]; other site 246196016682 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196016683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196016684 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196016685 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196016686 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 246196016687 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 246196016688 active site 246196016689 interdomain interaction site; other site 246196016690 putative metal-binding site [ion binding]; other site 246196016691 nucleotide binding site [chemical binding]; other site 246196016692 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 246196016693 domain I; other site 246196016694 DNA binding groove [nucleotide binding] 246196016695 phosphate binding site [ion binding]; other site 246196016696 domain II; other site 246196016697 domain III; other site 246196016698 nucleotide binding site [chemical binding]; other site 246196016699 catalytic site [active] 246196016700 domain IV; other site 246196016701 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 246196016702 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 246196016703 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246196016704 DNA-binding site [nucleotide binding]; DNA binding site 246196016705 RNA-binding motif; other site 246196016706 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 246196016707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196016708 ATP binding site [chemical binding]; other site 246196016709 putative Mg++ binding site [ion binding]; other site 246196016710 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196016711 nucleotide binding region [chemical binding]; other site 246196016712 ATP-binding site [chemical binding]; other site 246196016713 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 246196016714 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196016715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196016716 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196016717 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196016718 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 246196016719 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 246196016720 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 246196016721 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 246196016722 ATP binding site [chemical binding]; other site 246196016723 Walker A motif; other site 246196016724 hexamer interface [polypeptide binding]; other site 246196016725 Walker B motif; other site 246196016726 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 246196016727 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196016728 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 246196016729 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 246196016730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196016731 motif II; other site 246196016732 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196016733 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196016734 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196016735 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 246196016736 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 246196016737 active site 246196016738 intersubunit interface [polypeptide binding]; other site 246196016739 catalytic residue [active] 246196016740 galactonate dehydratase; Provisional; Region: PRK14017 246196016741 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 246196016742 putative active site pocket [active] 246196016743 putative metal binding site [ion binding]; other site 246196016744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196016745 D-galactonate transporter; Region: 2A0114; TIGR00893 246196016746 putative substrate translocation pore; other site 246196016747 acetyl-CoA synthetase; Provisional; Region: PRK00174 246196016748 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 246196016749 active site 246196016750 CoA binding site [chemical binding]; other site 246196016751 acyl-activating enzyme (AAE) consensus motif; other site 246196016752 AMP binding site [chemical binding]; other site 246196016753 acetate binding site [chemical binding]; other site 246196016754 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 246196016755 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196016756 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196016757 Colicin V production protein; Region: Colicin_V; pfam02674 246196016758 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246196016759 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246196016760 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 246196016761 putative active site [active] 246196016762 putative CoA binding site [chemical binding]; other site 246196016763 nudix motif; other site 246196016764 metal binding site [ion binding]; metal-binding site 246196016765 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246196016766 catalytic residues [active] 246196016767 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 246196016768 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246196016769 minor groove reading motif; other site 246196016770 helix-hairpin-helix signature motif; other site 246196016771 substrate binding pocket [chemical binding]; other site 246196016772 active site 246196016773 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 246196016774 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246196016775 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246196016776 ligand binding site [chemical binding]; other site 246196016777 flexible hinge region; other site 246196016778 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 246196016779 putative switch regulator; other site 246196016780 non-specific DNA interactions [nucleotide binding]; other site 246196016781 DNA binding site [nucleotide binding] 246196016782 sequence specific DNA binding site [nucleotide binding]; other site 246196016783 putative cAMP binding site [chemical binding]; other site 246196016784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196016785 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246196016786 homotrimer interaction site [polypeptide binding]; other site 246196016787 putative active site [active] 246196016788 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 246196016789 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 246196016790 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246196016791 P loop; other site 246196016792 Nucleotide binding site [chemical binding]; other site 246196016793 DTAP/Switch II; other site 246196016794 Switch I; other site 246196016795 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 246196016796 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246196016797 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 246196016798 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 246196016799 Spore germination protein; Region: Spore_permease; cl17796 246196016800 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Uncharacterized Proteins with similarity to Ornithine and Diaminopimelate Decarboxylases; Region: PLPDE_III_ODC_DapDC_like_1; cd06836 246196016801 dimer interface [polypeptide binding]; other site 246196016802 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 246196016803 active site 246196016804 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246196016805 catalytic residues [active] 246196016806 substrate binding site [chemical binding]; other site 246196016807 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 246196016808 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196016809 Transcription factor WhiB; Region: Whib; pfam02467 246196016810 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 246196016811 Transglycosylase; Region: Transgly; pfam00912 246196016812 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 246196016813 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246196016814 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246196016815 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 246196016816 putative active site [active] 246196016817 putative metal binding site [ion binding]; other site 246196016818 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 246196016819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196016820 catalytic residue [active] 246196016821 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246196016822 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196016823 active site 246196016824 ATP binding site [chemical binding]; other site 246196016825 substrate binding site [chemical binding]; other site 246196016826 activation loop (A-loop); other site 246196016827 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 246196016828 putative hydrophobic ligand binding site [chemical binding]; other site 246196016829 protein interface [polypeptide binding]; other site 246196016830 gate; other site 246196016831 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246196016832 acyl-CoA thioesterase II; Region: tesB; TIGR00189 246196016833 active site 246196016834 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246196016835 catalytic triad [active] 246196016836 dimer interface [polypeptide binding]; other site 246196016837 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 246196016838 Fe binding site [ion binding]; other site 246196016839 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 246196016840 dimanganese center [ion binding]; other site 246196016841 Yqey-like protein; Region: YqeY; pfam09424 246196016842 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 246196016843 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 246196016844 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 246196016845 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 246196016846 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196016847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016848 Walker A motif; other site 246196016849 ATP binding site [chemical binding]; other site 246196016850 Walker B motif; other site 246196016851 arginine finger; other site 246196016852 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246196016853 Protein of unknown function DUF58; Region: DUF58; pfam01882 246196016854 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 246196016855 Predicted membrane protein/domain [Function unknown]; Region: COG1714 246196016856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196016858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196016859 putative substrate translocation pore; other site 246196016860 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 246196016861 Predicted transcriptional regulators [Transcription]; Region: COG1695 246196016862 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 246196016863 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 246196016864 glycerol kinase; Provisional; Region: glpK; PRK00047 246196016865 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 246196016866 N- and C-terminal domain interface [polypeptide binding]; other site 246196016867 active site 246196016868 MgATP binding site [chemical binding]; other site 246196016869 catalytic site [active] 246196016870 metal binding site [ion binding]; metal-binding site 246196016871 putative homotetramer interface [polypeptide binding]; other site 246196016872 glycerol binding site [chemical binding]; other site 246196016873 homodimer interface [polypeptide binding]; other site 246196016874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196016875 S-adenosylmethionine binding site [chemical binding]; other site 246196016876 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246196016877 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 246196016878 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 246196016879 tetramer interface [polypeptide binding]; other site 246196016880 heme binding pocket [chemical binding]; other site 246196016881 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196016882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196016883 S-adenosylmethionine binding site [chemical binding]; other site 246196016884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196016885 S-adenosylmethionine binding site [chemical binding]; other site 246196016886 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196016887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246196016888 active site 246196016889 phosphorylation site [posttranslational modification] 246196016890 intermolecular recognition site; other site 246196016891 dimerization interface [polypeptide binding]; other site 246196016892 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196016893 DNA binding residues [nucleotide binding] 246196016894 dimerization interface [polypeptide binding]; other site 246196016895 GAF domain; Region: GAF_3; pfam13492 246196016896 Histidine kinase; Region: HisKA_3; pfam07730 246196016897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246196016898 ATP binding site [chemical binding]; other site 246196016899 Mg2+ binding site [ion binding]; other site 246196016900 G-X-G motif; other site 246196016901 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 246196016902 active site 246196016903 NAD binding site [chemical binding]; other site 246196016904 metal binding site [ion binding]; metal-binding site 246196016905 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 246196016906 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246196016907 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246196016908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196016909 Walker A motif; other site 246196016910 ATP binding site [chemical binding]; other site 246196016911 Walker B motif; other site 246196016912 arginine finger; other site 246196016913 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 246196016914 dimer interface [polypeptide binding]; other site 246196016915 active site 246196016916 metal binding site [ion binding]; metal-binding site 246196016917 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196016918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196016919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196016920 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246196016921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196016922 putative substrate translocation pore; other site 246196016923 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 246196016924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196016925 catalytic residue [active] 246196016926 Uncharacterized conserved protein [Function unknown]; Region: COG4301 246196016927 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 246196016928 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 246196016929 putative active site [active] 246196016930 putative dimer interface [polypeptide binding]; other site 246196016931 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 246196016932 DinB superfamily; Region: DinB_2; pfam12867 246196016933 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 246196016934 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 246196016935 PknH-like extracellular domain; Region: PknH_C; pfam14032 246196016936 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246196016937 metal binding site 2 [ion binding]; metal-binding site 246196016938 putative DNA binding helix; other site 246196016939 metal binding site 1 [ion binding]; metal-binding site 246196016940 dimer interface [polypeptide binding]; other site 246196016941 structural Zn2+ binding site [ion binding]; other site 246196016942 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246196016943 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 246196016944 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 246196016945 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 246196016946 aspartate kinase; Reviewed; Region: PRK06635 246196016947 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 246196016948 putative nucleotide binding site [chemical binding]; other site 246196016949 putative catalytic residues [active] 246196016950 putative Mg ion binding site [ion binding]; other site 246196016951 putative aspartate binding site [chemical binding]; other site 246196016952 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 246196016953 putative allosteric regulatory site; other site 246196016954 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 246196016955 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196016956 FMN binding site [chemical binding]; other site 246196016957 dimer interface [polypeptide binding]; other site 246196016958 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 246196016959 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 246196016960 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246196016961 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196016962 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 246196016963 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 246196016964 active site 246196016965 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 246196016966 domain_subunit interface; other site 246196016967 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246196016968 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 246196016969 active site 246196016970 FMN binding site [chemical binding]; other site 246196016971 substrate binding site [chemical binding]; other site 246196016972 3Fe-4S cluster binding site [ion binding]; other site 246196016973 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246196016974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196016975 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 246196016976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196016977 non-specific DNA binding site [nucleotide binding]; other site 246196016978 salt bridge; other site 246196016979 sequence-specific DNA binding site [nucleotide binding]; other site 246196016980 Cupin domain; Region: Cupin_2; cl17218 246196016981 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 246196016982 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 246196016983 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 246196016984 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 246196016985 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 246196016986 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 246196016987 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 246196016988 MgtE intracellular N domain; Region: MgtE_N; pfam03448 246196016989 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 246196016990 Divalent cation transporter; Region: MgtE; pfam01769 246196016991 2-isopropylmalate synthase; Validated; Region: PRK03739 246196016992 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 246196016993 active site 246196016994 catalytic residues [active] 246196016995 metal binding site [ion binding]; metal-binding site 246196016996 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 246196016997 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 246196016998 Short C-terminal domain; Region: SHOCT; pfam09851 246196016999 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 246196017000 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 246196017001 active site 246196017002 catalytic site [active] 246196017003 substrate binding site [chemical binding]; other site 246196017004 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 246196017005 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246196017006 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 246196017007 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 246196017008 catalytic triad [active] 246196017009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196017010 recombination protein RecR; Reviewed; Region: recR; PRK00076 246196017011 Helix-hairpin-helix motif; Region: HHH; pfam00633 246196017012 RecR protein; Region: RecR; pfam02132 246196017013 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 246196017014 putative active site [active] 246196017015 putative metal-binding site [ion binding]; other site 246196017016 tetramer interface [polypeptide binding]; other site 246196017017 hypothetical protein; Validated; Region: PRK00153 246196017018 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246196017019 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246196017020 active site 246196017021 metal binding site [ion binding]; metal-binding site 246196017022 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 246196017023 hydrophobic ligand binding site; other site 246196017024 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196017025 FAD binding domain; Region: FAD_binding_4; pfam01565 246196017026 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246196017027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017028 S-adenosylmethionine binding site [chemical binding]; other site 246196017029 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 246196017030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196017031 Walker A motif; other site 246196017032 ATP binding site [chemical binding]; other site 246196017033 Walker B motif; other site 246196017034 arginine finger; other site 246196017035 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 246196017036 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 246196017037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196017038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196017039 homodimer interface [polypeptide binding]; other site 246196017040 catalytic residue [active] 246196017041 Paf1; Region: Paf1; pfam03985 246196017042 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246196017043 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246196017044 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246196017045 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196017046 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196017047 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196017048 FAD dependent oxidoreductase; Region: DAO; pfam01266 246196017049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196017050 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 246196017051 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 246196017052 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246196017053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017055 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196017056 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196017057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017058 putative substrate translocation pore; other site 246196017059 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 246196017060 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196017061 catalytic Zn binding site [ion binding]; other site 246196017062 structural Zn binding site [ion binding]; other site 246196017063 tetramer interface [polypeptide binding]; other site 246196017064 aldehyde dehydrogenase family 2 member; Region: PLN02466 246196017065 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 246196017066 NAD(P) binding site [chemical binding]; other site 246196017067 catalytic residues [active] 246196017068 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196017069 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 246196017070 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 246196017071 dimerization interface [polypeptide binding]; other site 246196017072 ligand binding site [chemical binding]; other site 246196017073 NADP binding site [chemical binding]; other site 246196017074 catalytic site [active] 246196017075 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196017076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 246196017077 DNA-binding site [nucleotide binding]; DNA binding site 246196017078 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196017079 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 246196017080 nucleotide binding site [chemical binding]; other site 246196017081 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 246196017082 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 246196017083 active site 246196017084 DNA binding site [nucleotide binding] 246196017085 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 246196017086 DNA binding site [nucleotide binding] 246196017087 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 246196017088 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 246196017089 active site 246196017090 DNA binding site [nucleotide binding] 246196017091 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 246196017092 DNA binding site [nucleotide binding] 246196017093 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 246196017094 substrate binding pocket [chemical binding]; other site 246196017095 catalytic triad [active] 246196017096 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 246196017097 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 246196017098 active site 246196017099 nucleotide binding site [chemical binding]; other site 246196017100 HIGH motif; other site 246196017101 KMSKS motif; other site 246196017102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196017103 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196017104 substrate binding pocket [chemical binding]; other site 246196017105 membrane-bound complex binding site; other site 246196017106 hinge residues; other site 246196017107 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196017108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017109 dimer interface [polypeptide binding]; other site 246196017110 conserved gate region; other site 246196017111 putative PBP binding loops; other site 246196017112 ABC-ATPase subunit interface; other site 246196017113 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196017114 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196017115 Walker A/P-loop; other site 246196017116 ATP binding site [chemical binding]; other site 246196017117 Q-loop/lid; other site 246196017118 ABC transporter signature motif; other site 246196017119 Walker B; other site 246196017120 D-loop; other site 246196017121 H-loop/switch region; other site 246196017122 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 246196017123 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 246196017124 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 246196017125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017126 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196017127 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 246196017128 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 246196017129 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 246196017130 haloalkane dehalogenase; Provisional; Region: PRK00870 246196017131 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196017132 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 246196017133 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 246196017134 active site 246196017135 catalytic triad [active] 246196017136 oxyanion hole [active] 246196017137 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 246196017138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196017139 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 246196017140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196017141 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 246196017142 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 246196017143 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 246196017144 alpha-beta subunit interface [polypeptide binding]; other site 246196017145 alpha-gamma subunit interface [polypeptide binding]; other site 246196017146 active site 246196017147 substrate and K+ binding site; other site 246196017148 K+ binding site [ion binding]; other site 246196017149 cobalamin binding site [chemical binding]; other site 246196017150 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 246196017151 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246196017152 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246196017153 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 246196017154 Animal haem peroxidase; Region: An_peroxidase; pfam03098 246196017155 putative heme binding site [chemical binding]; other site 246196017156 putative active site [active] 246196017157 putative substrate binding site [chemical binding]; other site 246196017158 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 246196017159 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246196017160 nucleoside/Zn binding site; other site 246196017161 dimer interface [polypeptide binding]; other site 246196017162 catalytic motif [active] 246196017163 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 246196017164 prephenate dehydrogenase; Validated; Region: PRK06545 246196017165 prephenate dehydrogenase; Validated; Region: PRK08507 246196017166 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 246196017167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017168 dimer interface [polypeptide binding]; other site 246196017169 ABC-ATPase subunit interface; other site 246196017170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017171 dimer interface [polypeptide binding]; other site 246196017172 conserved gate region; other site 246196017173 putative PBP binding loops; other site 246196017174 ABC-ATPase subunit interface; other site 246196017175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017176 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 246196017177 Walker A/P-loop; other site 246196017178 ATP binding site [chemical binding]; other site 246196017179 Q-loop/lid; other site 246196017180 ABC transporter signature motif; other site 246196017181 Walker B; other site 246196017182 D-loop; other site 246196017183 H-loop/switch region; other site 246196017184 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196017185 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 246196017186 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246196017187 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246196017188 putative active site [active] 246196017189 putative substrate binding site [chemical binding]; other site 246196017190 ATP binding site [chemical binding]; other site 246196017191 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196017192 catalytic core [active] 246196017193 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196017194 classical (c) SDRs; Region: SDR_c; cd05233 246196017195 NAD(P) binding site [chemical binding]; other site 246196017196 active site 246196017197 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 246196017198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196017199 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 246196017200 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 246196017201 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196017202 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 246196017203 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 246196017204 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246196017205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196017206 dimerization interface [polypeptide binding]; other site 246196017207 putative Zn2+ binding site [ion binding]; other site 246196017208 putative DNA binding site [nucleotide binding]; other site 246196017209 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 246196017210 active site 246196017211 metal binding site [ion binding]; metal-binding site 246196017212 homotetramer interface [polypeptide binding]; other site 246196017213 putative aminotransferase; Provisional; Region: PRK03321 246196017214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196017215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196017216 homodimer interface [polypeptide binding]; other site 246196017217 catalytic residue [active] 246196017218 GXWXG protein; Region: GXWXG; pfam14231 246196017219 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 246196017220 enoyl-CoA hydratase; Provisional; Region: PRK06142 246196017221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196017222 substrate binding site [chemical binding]; other site 246196017223 oxyanion hole (OAH) forming residues; other site 246196017224 trimer interface [polypeptide binding]; other site 246196017225 Cutinase; Region: Cutinase; pfam01083 246196017226 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246196017227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196017228 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 246196017229 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196017230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196017231 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 246196017232 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 246196017233 NAD(P) binding site [chemical binding]; other site 246196017234 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196017235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196017236 catalytic residue [active] 246196017237 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 246196017238 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 246196017239 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 246196017240 Walker A/P-loop; other site 246196017241 ATP binding site [chemical binding]; other site 246196017242 Q-loop/lid; other site 246196017243 ABC transporter signature motif; other site 246196017244 Walker B; other site 246196017245 D-loop; other site 246196017246 H-loop/switch region; other site 246196017247 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246196017248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196017249 active site 246196017250 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 246196017251 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 246196017252 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196017253 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246196017254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196017255 DNA-binding site [nucleotide binding]; DNA binding site 246196017256 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246196017257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246196017258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196017259 homodimer interface [polypeptide binding]; other site 246196017260 catalytic residue [active] 246196017261 Predicted membrane protein [Function unknown]; Region: COG2246 246196017262 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 246196017263 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 246196017264 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 246196017265 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 246196017266 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 246196017267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017268 putative substrate translocation pore; other site 246196017269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196017270 DNA binding site [nucleotide binding] 246196017271 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196017272 domain linker motif; other site 246196017273 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196017274 dimerization interface [polypeptide binding]; other site 246196017275 ligand binding site [chemical binding]; other site 246196017276 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246196017277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017278 putative substrate translocation pore; other site 246196017279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196017280 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196017281 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 246196017282 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246196017283 FAD binding domain; Region: FAD_binding_4; pfam01565 246196017284 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 246196017285 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246196017286 metal binding site 2 [ion binding]; metal-binding site 246196017287 putative DNA binding helix; other site 246196017288 metal binding site 1 [ion binding]; metal-binding site 246196017289 dimer interface [polypeptide binding]; other site 246196017290 structural Zn2+ binding site [ion binding]; other site 246196017291 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 246196017292 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 246196017293 dimer interface [polypeptide binding]; other site 246196017294 active site 246196017295 heme binding site [chemical binding]; other site 246196017296 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 246196017297 short chain dehydrogenase; Provisional; Region: PRK07904 246196017298 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246196017299 NAD(P) binding site [chemical binding]; other site 246196017300 active site 246196017301 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 246196017302 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 246196017303 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 246196017304 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 246196017305 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 246196017306 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 246196017307 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 246196017308 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 246196017309 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196017310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017311 putative substrate translocation pore; other site 246196017312 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196017313 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246196017314 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196017315 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196017316 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246196017317 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196017318 active site 246196017319 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196017320 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246196017321 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 246196017322 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 246196017323 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246196017324 acyl-activating enzyme (AAE) consensus motif; other site 246196017325 active site 246196017326 Cutinase; Region: Cutinase; pfam01083 246196017327 Predicted esterase [General function prediction only]; Region: COG0627 246196017328 Predicted esterase [General function prediction only]; Region: COG0627 246196017329 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196017330 Putative esterase; Region: Esterase; pfam00756 246196017331 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196017332 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 246196017333 putative active site [active] 246196017334 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 246196017335 active site 246196017336 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246196017337 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246196017338 active site 246196017339 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 246196017340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196017341 UDP-galactopyranose mutase; Region: GLF; pfam03275 246196017342 large tegument protein UL36; Provisional; Region: PHA03247 246196017343 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 246196017344 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 246196017345 amidase catalytic site [active] 246196017346 Zn binding residues [ion binding]; other site 246196017347 substrate binding site [chemical binding]; other site 246196017348 LGFP repeat; Region: LGFP; pfam08310 246196017349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246196017350 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 246196017351 active site 246196017352 motif I; other site 246196017353 motif II; other site 246196017354 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 246196017355 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196017356 putative acyl-acceptor binding pocket; other site 246196017357 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246196017358 putative acyl-acceptor binding pocket; other site 246196017359 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246196017360 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246196017361 iron-sulfur cluster [ion binding]; other site 246196017362 [2Fe-2S] cluster binding site [ion binding]; other site 246196017363 seryl-tRNA synthetase; Provisional; Region: PRK05431 246196017364 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 246196017365 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 246196017366 dimer interface [polypeptide binding]; other site 246196017367 active site 246196017368 motif 1; other site 246196017369 motif 2; other site 246196017370 motif 3; other site 246196017371 Septum formation; Region: Septum_form; pfam13845 246196017372 Septum formation; Region: Septum_form; pfam13845 246196017373 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 246196017374 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196017375 catalytic core [active] 246196017376 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246196017377 prephenate dehydratase; Provisional; Region: PRK11898 246196017378 Prephenate dehydratase; Region: PDT; pfam00800 246196017379 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 246196017380 putative L-Phe binding site [chemical binding]; other site 246196017381 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 246196017382 CAAX protease self-immunity; Region: Abi; pfam02517 246196017383 Transcriptional regulator [Transcription]; Region: LytR; COG1316 246196017384 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 246196017385 Ferritin-like domain; Region: Ferritin; pfam00210 246196017386 ferroxidase diiron center [ion binding]; other site 246196017387 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 246196017388 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 246196017389 putative active site [active] 246196017390 catalytic site [active] 246196017391 putative metal binding site [ion binding]; other site 246196017392 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 246196017393 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246196017394 active site residue [active] 246196017395 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 246196017396 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 246196017397 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 246196017398 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246196017399 internal virion protein D; Region: PHA00368 246196017400 CopC domain; Region: CopC; pfam04234 246196017401 Copper resistance protein D; Region: CopD; pfam05425 246196017402 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 246196017403 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246196017404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246196017405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017407 DNA polymerase IV; Validated; Region: PRK03858 246196017408 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246196017409 active site 246196017410 DNA binding site [nucleotide binding] 246196017411 yiaA/B two helix domain; Region: YiaAB; cl01759 246196017412 hypothetical protein; Provisional; Region: PRK07945 246196017413 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 246196017414 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 246196017415 active site 246196017416 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 246196017417 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196017418 dimerization interface [polypeptide binding]; other site 246196017419 putative DNA binding site [nucleotide binding]; other site 246196017420 putative Zn2+ binding site [ion binding]; other site 246196017421 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 246196017422 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246196017423 Sulfate transporter family; Region: Sulfate_transp; cl19250 246196017424 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 246196017425 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 246196017426 NAD(P) binding site [chemical binding]; other site 246196017427 catalytic residues [active] 246196017428 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 246196017429 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 246196017430 Moco binding site; other site 246196017431 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 246196017432 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 246196017433 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 246196017434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246196017435 NAD(P) binding pocket [chemical binding]; other site 246196017436 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 246196017437 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 246196017438 active site 246196017439 dimer interface [polypeptide binding]; other site 246196017440 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 246196017441 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246196017442 active site 246196017443 FMN binding site [chemical binding]; other site 246196017444 substrate binding site [chemical binding]; other site 246196017445 3Fe-4S cluster binding site [ion binding]; other site 246196017446 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 246196017447 domain interface; other site 246196017448 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196017449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196017450 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196017451 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196017452 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196017453 active site 2 [active] 246196017454 active site 1 [active] 246196017455 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246196017456 CoenzymeA binding site [chemical binding]; other site 246196017457 subunit interaction site [polypeptide binding]; other site 246196017458 PHB binding site; other site 246196017459 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 246196017460 Cl- selectivity filter; other site 246196017461 Cl- binding residues [ion binding]; other site 246196017462 pore gating glutamate residue; other site 246196017463 dimer interface [polypeptide binding]; other site 246196017464 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 246196017465 amphipathic channel; other site 246196017466 Asn-Pro-Ala signature motifs; other site 246196017467 Ferritin-like domain; Region: Ferritin; pfam00210 246196017468 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 246196017469 dimerization interface [polypeptide binding]; other site 246196017470 DPS ferroxidase diiron center [ion binding]; other site 246196017471 ion pore; other site 246196017472 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 246196017473 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 246196017474 minor groove reading motif; other site 246196017475 helix-hairpin-helix signature motif; other site 246196017476 active site 246196017477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 246196017478 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 246196017479 FAD dependent oxidoreductase; Region: DAO; pfam01266 246196017480 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 246196017481 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 246196017482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017483 NAD(P) binding site [chemical binding]; other site 246196017484 active site 246196017485 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196017486 methionine sulfoxide reductase A; Provisional; Region: PRK14054 246196017487 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196017488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017491 Methyltransferase domain; Region: Methyltransf_24; pfam13578 246196017492 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 246196017493 Protein of unknown function, DUF608; Region: DUF608; pfam04685 246196017494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017495 S-adenosylmethionine binding site [chemical binding]; other site 246196017496 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246196017497 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246196017498 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196017499 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 246196017500 active site 246196017501 FMN binding site [chemical binding]; other site 246196017502 substrate binding site [chemical binding]; other site 246196017503 homotetramer interface [polypeptide binding]; other site 246196017504 catalytic residue [active] 246196017505 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196017506 Cupin domain; Region: Cupin_2; cl17218 246196017507 hypothetical protein; Provisional; Region: PRK07236 246196017508 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246196017509 benzoate transport; Region: 2A0115; TIGR00895 246196017510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017511 putative substrate translocation pore; other site 246196017512 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 246196017513 NAD(P) binding site [chemical binding]; other site 246196017514 catalytic residues [active] 246196017515 GAF domain; Region: GAF; pfam01590 246196017516 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 246196017517 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196017518 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196017519 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 246196017520 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196017521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017522 dimer interface [polypeptide binding]; other site 246196017523 conserved gate region; other site 246196017524 putative PBP binding loops; other site 246196017525 ABC-ATPase subunit interface; other site 246196017526 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246196017527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017528 dimer interface [polypeptide binding]; other site 246196017529 conserved gate region; other site 246196017530 putative PBP binding loops; other site 246196017531 ABC-ATPase subunit interface; other site 246196017532 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246196017533 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246196017534 Walker A/P-loop; other site 246196017535 ATP binding site [chemical binding]; other site 246196017536 Q-loop/lid; other site 246196017537 ABC transporter signature motif; other site 246196017538 Walker B; other site 246196017539 D-loop; other site 246196017540 H-loop/switch region; other site 246196017541 Domain of unknown function (DUF427); Region: DUF427; cl00998 246196017542 putative transcriptional regulator; Provisional; Region: PRK11640 246196017543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017544 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 246196017545 FMN binding site [chemical binding]; other site 246196017546 dimer interface [polypeptide binding]; other site 246196017547 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 246196017548 catalytic triad [active] 246196017549 conserved cis-peptide bond; other site 246196017550 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 246196017551 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 246196017552 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 246196017553 active site 246196017554 catalytic site [active] 246196017555 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196017556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196017557 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 246196017558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017559 Walker A/P-loop; other site 246196017560 ATP binding site [chemical binding]; other site 246196017561 Q-loop/lid; other site 246196017562 ABC transporter signature motif; other site 246196017563 Walker B; other site 246196017564 D-loop; other site 246196017565 H-loop/switch region; other site 246196017566 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246196017567 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196017568 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 246196017569 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017570 active site 246196017571 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 246196017572 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196017573 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196017574 active site 246196017575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196017576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246196017577 putative substrate translocation pore; other site 246196017578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246196017579 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl19286 246196017580 Phosphotransferase enzyme family; Region: APH; pfam01636 246196017581 trehalose synthase; Region: treS_nterm; TIGR02456 246196017582 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 246196017583 active site 246196017584 catalytic site [active] 246196017585 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 246196017586 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 246196017587 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 246196017588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246196017589 active site 246196017590 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196017591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017592 Walker A/P-loop; other site 246196017593 ATP binding site [chemical binding]; other site 246196017594 Q-loop/lid; other site 246196017595 ABC transporter signature motif; other site 246196017596 Walker B; other site 246196017597 D-loop; other site 246196017598 H-loop/switch region; other site 246196017599 TOBE domain; Region: TOBE_2; pfam08402 246196017600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017601 dimer interface [polypeptide binding]; other site 246196017602 conserved gate region; other site 246196017603 putative PBP binding loops; other site 246196017604 ABC-ATPase subunit interface; other site 246196017605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 246196017606 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196017607 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246196017608 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 246196017609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017610 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 246196017611 Subunit I/III interface [polypeptide binding]; other site 246196017612 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 246196017613 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017615 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246196017616 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246196017617 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196017618 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 246196017619 elongation factor G; Reviewed; Region: PRK12740 246196017620 G1 box; other site 246196017621 putative GEF interaction site [polypeptide binding]; other site 246196017622 GTP/Mg2+ binding site [chemical binding]; other site 246196017623 Switch I region; other site 246196017624 G2 box; other site 246196017625 G3 box; other site 246196017626 Switch II region; other site 246196017627 G4 box; other site 246196017628 G5 box; other site 246196017629 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 246196017630 Elongation Factor G, domain II; Region: EFG_II; pfam14492 246196017631 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 246196017632 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 246196017633 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246196017634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017636 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196017637 classical (c) SDRs; Region: SDR_c; cd05233 246196017638 NAD(P) binding site [chemical binding]; other site 246196017639 active site 246196017640 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 246196017641 mce related protein; Region: MCE; pfam02470 246196017642 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 246196017643 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 246196017644 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246196017645 anti sigma factor interaction site; other site 246196017646 regulatory phosphorylation site [posttranslational modification]; other site 246196017647 B12 binding domain; Region: B12-binding_2; pfam02607 246196017648 B12 binding domain; Region: B12-binding; pfam02310 246196017649 B12 binding site [chemical binding]; other site 246196017650 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246196017651 catalytic core [active] 246196017652 Cupin domain; Region: Cupin_2; cl17218 246196017653 Helix-turn-helix domain; Region: HTH_18; pfam12833 246196017654 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196017655 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 246196017656 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246196017657 iron-sulfur cluster [ion binding]; other site 246196017658 [2Fe-2S] cluster binding site [ion binding]; other site 246196017659 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 246196017660 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196017661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017662 Walker A/P-loop; other site 246196017663 ATP binding site [chemical binding]; other site 246196017664 Q-loop/lid; other site 246196017665 ABC transporter signature motif; other site 246196017666 Walker B; other site 246196017667 D-loop; other site 246196017668 H-loop/switch region; other site 246196017669 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 246196017670 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246196017671 FAD binding pocket [chemical binding]; other site 246196017672 FAD binding motif [chemical binding]; other site 246196017673 phosphate binding motif [ion binding]; other site 246196017674 NAD binding pocket [chemical binding]; other site 246196017675 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246196017676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246196017677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017678 Walker A/P-loop; other site 246196017679 ATP binding site [chemical binding]; other site 246196017680 Q-loop/lid; other site 246196017681 ABC transporter signature motif; other site 246196017682 Walker B; other site 246196017683 D-loop; other site 246196017684 H-loop/switch region; other site 246196017685 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 246196017686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017688 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196017689 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196017690 substrate binding site [chemical binding]; other site 246196017691 oxyanion hole (OAH) forming residues; other site 246196017692 trimer interface [polypeptide binding]; other site 246196017693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017694 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196017695 NAD(P) binding site [chemical binding]; other site 246196017696 active site 246196017697 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 246196017698 DUF35 OB-fold domain; Region: DUF35; pfam01796 246196017699 thiolase; Provisional; Region: PRK06158 246196017700 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246196017701 active site 246196017702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017703 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 246196017704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017706 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017707 active site 246196017708 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 246196017709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017710 NAD(P) binding site [chemical binding]; other site 246196017711 active site 246196017712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246196017715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246196017716 Coenzyme A binding pocket [chemical binding]; other site 246196017717 PAS domain; Region: PAS_8; pfam13188 246196017718 PAS domain; Region: PAS_9; pfam13426 246196017719 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 246196017720 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196017721 DNA binding residues [nucleotide binding] 246196017722 dimerization interface [polypeptide binding]; other site 246196017723 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 246196017724 Protein of unknown function (DUF461); Region: DUF461; pfam04314 246196017725 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 246196017726 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 246196017727 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 246196017728 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 246196017729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017730 S-adenosylmethionine binding site [chemical binding]; other site 246196017731 Domain of unknown function (DUF222); Region: DUF222; pfam02720 246196017732 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246196017733 active site 246196017734 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 246196017735 heme-binding site [chemical binding]; other site 246196017736 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196017737 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196017738 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246196017739 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196017740 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 246196017741 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196017742 short chain dehydrogenase; Validated; Region: PRK08264 246196017743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017744 NAD(P) binding site [chemical binding]; other site 246196017745 active site 246196017746 Predicted esterase [General function prediction only]; Region: COG0627 246196017747 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 246196017748 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 246196017749 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017750 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017751 active site 246196017752 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017753 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 246196017754 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 246196017755 active site 246196017756 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196017757 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196017758 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246196017759 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 246196017760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246196017761 ATP binding site [chemical binding]; other site 246196017762 putative Mg++ binding site [ion binding]; other site 246196017763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246196017764 nucleotide binding region [chemical binding]; other site 246196017765 ATP-binding site [chemical binding]; other site 246196017766 Helicase associated domain (HA2); Region: HA2; pfam04408 246196017767 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 246196017768 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 246196017769 Helix-turn-helix domain; Region: HTH_28; pfam13518 246196017770 Winged helix-turn helix; Region: HTH_29; pfam13551 246196017771 Homeodomain-like domain; Region: HTH_32; pfam13565 246196017772 DDE superfamily endonuclease; Region: DDE_3; cl19249 246196017773 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 246196017774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017775 short chain dehydrogenase; Provisional; Region: PRK07454 246196017776 NAD(P) binding site [chemical binding]; other site 246196017777 active site 246196017778 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 246196017779 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246196017780 catalytic residue [active] 246196017781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 246196017782 YheO-like PAS domain; Region: PAS_6; pfam08348 246196017783 HTH domain; Region: HTH_22; pfam13309 246196017784 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196017785 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196017786 Walker A/P-loop; other site 246196017787 ATP binding site [chemical binding]; other site 246196017788 Q-loop/lid; other site 246196017789 ABC transporter signature motif; other site 246196017790 Walker B; other site 246196017791 D-loop; other site 246196017792 H-loop/switch region; other site 246196017793 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 246196017794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017795 dimer interface [polypeptide binding]; other site 246196017796 conserved gate region; other site 246196017797 putative PBP binding loops; other site 246196017798 ABC-ATPase subunit interface; other site 246196017799 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196017800 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196017801 substrate binding pocket [chemical binding]; other site 246196017802 membrane-bound complex binding site; other site 246196017803 hinge residues; other site 246196017804 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196017805 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196017806 riboflavin synthase subunit beta; Provisional; Region: PRK12419 246196017807 active site 246196017808 homopentamer interface [polypeptide binding]; other site 246196017809 Homeodomain-like domain; Region: HTH_23; cl17451 246196017810 Winged helix-turn helix; Region: HTH_29; pfam13551 246196017811 Integrase core domain; Region: rve; pfam00665 246196017812 Integrase core domain; Region: rve_3; pfam13683 246196017813 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246196017814 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196017815 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196017816 Predicted transcriptional regulators [Transcription]; Region: COG1695 246196017817 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 246196017818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017820 von Willebrand factor type A domain; Region: VWA_2; pfam13519 246196017821 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246196017822 Protein of unknown function DUF58; Region: DUF58; pfam01882 246196017823 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196017824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196017825 Walker A motif; other site 246196017826 ATP binding site [chemical binding]; other site 246196017827 Walker B motif; other site 246196017828 arginine finger; other site 246196017829 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246196017830 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 246196017831 putative active site [active] 246196017832 putative metal binding site [ion binding]; other site 246196017833 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246196017834 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 246196017835 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246196017836 NAD binding site [chemical binding]; other site 246196017837 catalytic Zn binding site [ion binding]; other site 246196017838 structural Zn binding site [ion binding]; other site 246196017839 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 246196017840 putative active site [active] 246196017841 putative CoA binding site [chemical binding]; other site 246196017842 nudix motif; other site 246196017843 metal binding site [ion binding]; metal-binding site 246196017844 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196017845 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196017846 short chain dehydrogenase; Region: adh_short; pfam00106 246196017847 classical (c) SDRs; Region: SDR_c; cd05233 246196017848 NAD(P) binding site [chemical binding]; other site 246196017849 active site 246196017850 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 246196017851 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196017852 active site 246196017853 metal binding site [ion binding]; metal-binding site 246196017854 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196017855 classical (c) SDRs; Region: SDR_c; cd05233 246196017856 NAD(P) binding site [chemical binding]; other site 246196017857 active site 246196017858 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 246196017859 FMN binding site [chemical binding]; other site 246196017860 dimer interface [polypeptide binding]; other site 246196017861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196017862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196017863 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246196017864 active site 246196017865 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 246196017866 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 246196017867 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 246196017868 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 246196017869 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 246196017870 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 246196017871 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 246196017872 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 246196017873 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 246196017874 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 246196017875 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 246196017876 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 246196017877 THF binding site; other site 246196017878 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 246196017879 substrate binding site [chemical binding]; other site 246196017880 THF binding site; other site 246196017881 zinc-binding site [ion binding]; other site 246196017882 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196017883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196017884 DNA-binding site [nucleotide binding]; DNA binding site 246196017885 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 246196017886 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 246196017887 active site 246196017888 non-prolyl cis peptide bond; other site 246196017889 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196017890 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 246196017891 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196017892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196017893 non-specific DNA binding site [nucleotide binding]; other site 246196017894 salt bridge; other site 246196017895 sequence-specific DNA binding site [nucleotide binding]; other site 246196017896 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 246196017897 Domain of unknown function (DUF955); Region: DUF955; pfam06114 246196017898 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 246196017899 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 246196017900 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196017901 tetramer interface [polypeptide binding]; other site 246196017902 active site 246196017903 Mg2+/Mn2+ binding site [ion binding]; other site 246196017904 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 246196017905 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 246196017906 dimer interface [polypeptide binding]; other site 246196017907 active site 246196017908 citrylCoA binding site [chemical binding]; other site 246196017909 oxalacetate/citrate binding site [chemical binding]; other site 246196017910 coenzyme A binding site [chemical binding]; other site 246196017911 catalytic triad [active] 246196017912 pyruvate carboxylase; Reviewed; Region: PRK12999 246196017913 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246196017914 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246196017915 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246196017916 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 246196017917 active site 246196017918 catalytic residues [active] 246196017919 metal binding site [ion binding]; metal-binding site 246196017920 homodimer binding site [polypeptide binding]; other site 246196017921 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 246196017922 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246196017923 carboxyltransferase (CT) interaction site; other site 246196017924 biotinylation site [posttranslational modification]; other site 246196017925 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 246196017926 Septum formation initiator; Region: DivIC; cl17659 246196017927 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 246196017928 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 246196017929 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 246196017930 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 246196017931 DNA binding site [nucleotide binding] 246196017932 active site 246196017933 Int/Topo IB signature motif; other site 246196017934 catalytic residues [active] 246196017935 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 246196017936 Coenzyme A transferase; Region: CoA_trans; cl17247 246196017937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196017938 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246196017939 catalytic site [active] 246196017940 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246196017941 Na binding site [ion binding]; other site 246196017942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196017943 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 246196017944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246196017945 classical (c) SDRs; Region: SDR_c; cd05233 246196017946 NAD(P) binding site [chemical binding]; other site 246196017947 active site 246196017948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196017949 S-adenosylmethionine binding site [chemical binding]; other site 246196017950 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 246196017951 FAD binding site [chemical binding]; other site 246196017952 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 246196017953 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 246196017954 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246196017955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017956 dimer interface [polypeptide binding]; other site 246196017957 conserved gate region; other site 246196017958 putative PBP binding loops; other site 246196017959 ABC-ATPase subunit interface; other site 246196017960 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 246196017961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196017962 dimer interface [polypeptide binding]; other site 246196017963 conserved gate region; other site 246196017964 putative PBP binding loops; other site 246196017965 ABC-ATPase subunit interface; other site 246196017966 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246196017967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196017968 Walker A/P-loop; other site 246196017969 ATP binding site [chemical binding]; other site 246196017970 Q-loop/lid; other site 246196017971 ABC transporter signature motif; other site 246196017972 Walker B; other site 246196017973 D-loop; other site 246196017974 H-loop/switch region; other site 246196017975 TOBE domain; Region: TOBE_2; pfam08402 246196017976 Sulfatase; Region: Sulfatase; cl19157 246196017977 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246196017978 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196017979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196017980 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 246196017981 substrate binding pocket [chemical binding]; other site 246196017982 dimerization interface [polypeptide binding]; other site 246196017983 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 246196017984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196017985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196017986 dimerization interface [polypeptide binding]; other site 246196017987 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246196017988 Protein of unknown function, DUF417; Region: DUF417; cl01162 246196017989 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246196017990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246196017991 AhpC/TSA family; Region: AhpC-TSA; pfam00578 246196017992 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196017993 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196017994 inhibitor-cofactor binding pocket; inhibition site 246196017995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196017996 catalytic residue [active] 246196017997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246196017998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246196017999 active site 246196018000 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246196018001 NAD(P) binding site [chemical binding]; other site 246196018002 catalytic residues [active] 246196018003 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196018004 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 246196018005 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 246196018006 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 246196018007 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 246196018008 conserved cys residue [active] 246196018009 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 246196018010 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 246196018011 catalytic triad [active] 246196018012 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196018013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196018014 substrate binding pocket [chemical binding]; other site 246196018015 membrane-bound complex binding site; other site 246196018016 hinge residues; other site 246196018017 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246196018018 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246196018019 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 246196018020 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246196018021 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 246196018022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246196018023 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246196018024 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 246196018025 Cache domain; Region: Cache_1; pfam02743 246196018026 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246196018027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018028 DNA-binding site [nucleotide binding]; DNA binding site 246196018029 FCD domain; Region: FCD; pfam07729 246196018030 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196018031 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196018032 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 246196018033 NAD(P) binding site [chemical binding]; other site 246196018034 catalytic residues [active] 246196018035 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196018036 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196018037 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196018038 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196018039 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196018040 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 246196018041 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 246196018042 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 246196018043 shikimate binding site; other site 246196018044 NAD(P) binding site [chemical binding]; other site 246196018045 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018046 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196018047 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196018048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196018049 NAD(P) binding site [chemical binding]; other site 246196018050 active site 246196018051 Probable pheophorbidase; Region: PLN02965; cl17657 246196018052 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018053 benzoate transport; Region: 2A0115; TIGR00895 246196018054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196018055 putative substrate translocation pore; other site 246196018056 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 246196018057 active site 246196018058 dimer interface [polypeptide binding]; other site 246196018059 metal binding site [ion binding]; metal-binding site 246196018060 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 246196018061 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 246196018062 active site 246196018063 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196018064 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196018065 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196018066 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196018067 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196018068 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246196018069 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246196018070 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246196018071 benzoate transport; Region: 2A0115; TIGR00895 246196018072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196018073 putative substrate translocation pore; other site 246196018074 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196018075 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018076 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018077 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196018078 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 246196018079 hypothetical protein; Provisional; Region: PRK06547 246196018080 AAA domain; Region: AAA_33; pfam13671 246196018081 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 246196018082 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196018083 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246196018084 Walker A/P-loop; other site 246196018085 ATP binding site [chemical binding]; other site 246196018086 Q-loop/lid; other site 246196018087 ABC transporter signature motif; other site 246196018088 Walker B; other site 246196018089 D-loop; other site 246196018090 H-loop/switch region; other site 246196018091 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246196018092 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 246196018093 Walker A/P-loop; other site 246196018094 ATP binding site [chemical binding]; other site 246196018095 Q-loop/lid; other site 246196018096 ABC transporter signature motif; other site 246196018097 Walker B; other site 246196018098 D-loop; other site 246196018099 H-loop/switch region; other site 246196018100 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 246196018101 amino acid transporter; Region: 2A0306; TIGR00909 246196018102 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196018103 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 246196018104 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196018105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196018106 active site 246196018107 catalytic tetrad [active] 246196018108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196018109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196018110 salt bridge; other site 246196018111 non-specific DNA binding site [nucleotide binding]; other site 246196018112 sequence-specific DNA binding site [nucleotide binding]; other site 246196018113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196018114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018115 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 246196018116 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 246196018117 putative active site [active] 246196018118 catalytic triad [active] 246196018119 putative dimer interface [polypeptide binding]; other site 246196018120 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196018121 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 246196018122 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 246196018123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196018124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196018125 DNA binding site [nucleotide binding] 246196018126 domain linker motif; other site 246196018127 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 246196018128 Protein of unknown function (DUF732); Region: DUF732; pfam05305 246196018129 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018131 DNA-binding site [nucleotide binding]; DNA binding site 246196018132 FCD domain; Region: FCD; pfam07729 246196018133 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 246196018134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196018135 catalytic residue [active] 246196018136 GAF domain; Region: GAF_2; pfam13185 246196018137 ANTAR domain; Region: ANTAR; pfam03861 246196018138 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 246196018139 CGNR zinc finger; Region: zf-CGNR; pfam11706 246196018140 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246196018141 active site 246196018142 metal binding site [ion binding]; metal-binding site 246196018143 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 246196018144 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246196018145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018146 DNA-binding site [nucleotide binding]; DNA binding site 246196018147 UTRA domain; Region: UTRA; pfam07702 246196018148 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246196018149 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 246196018150 active site 246196018151 catalytic tetrad [active] 246196018152 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246196018153 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246196018154 putative NAD(P) binding site [chemical binding]; other site 246196018155 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246196018156 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196018157 ABC transporter; Region: ABC_tran_2; pfam12848 246196018158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246196018159 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 246196018160 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246196018161 classical (c) SDRs; Region: SDR_c; cd05233 246196018162 NAD(P) binding site [chemical binding]; other site 246196018163 active site 246196018164 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246196018165 active site 246196018166 catalytic site [active] 246196018167 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246196018168 active site 2 [active] 246196018169 active site 1 [active] 246196018170 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 246196018171 NAD(P) binding site [chemical binding]; other site 246196018172 active site lysine 246196018173 glycerol kinase; Provisional; Region: glpK; PRK00047 246196018174 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 246196018175 N- and C-terminal domain interface [polypeptide binding]; other site 246196018176 active site 246196018177 MgATP binding site [chemical binding]; other site 246196018178 catalytic site [active] 246196018179 metal binding site [ion binding]; metal-binding site 246196018180 putative homotetramer interface [polypeptide binding]; other site 246196018181 glycerol binding site [chemical binding]; other site 246196018182 homodimer interface [polypeptide binding]; other site 246196018183 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196018184 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196018185 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196018186 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 246196018187 amphipathic channel; other site 246196018188 Asn-Pro-Ala signature motifs; other site 246196018189 glycerol kinase; Provisional; Region: glpK; PRK00047 246196018190 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196018191 nucleotide binding site [chemical binding]; other site 246196018192 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 246196018193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196018194 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 246196018195 putative hydrophobic ligand binding site [chemical binding]; other site 246196018196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196018197 dimerization interface [polypeptide binding]; other site 246196018198 putative DNA binding site [nucleotide binding]; other site 246196018199 putative Zn2+ binding site [ion binding]; other site 246196018200 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196018201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246196018203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018204 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 246196018205 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246196018206 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246196018207 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246196018208 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246196018209 Walker A/P-loop; other site 246196018210 ATP binding site [chemical binding]; other site 246196018211 Q-loop/lid; other site 246196018212 ABC transporter signature motif; other site 246196018213 Walker B; other site 246196018214 D-loop; other site 246196018215 H-loop/switch region; other site 246196018216 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246196018217 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246196018218 active site 246196018219 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246196018220 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 246196018221 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246196018222 short chain dehydrogenase; Region: adh_short; pfam00106 246196018223 putative NADP binding site [chemical binding]; other site 246196018224 active site 246196018225 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246196018226 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 246196018227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196018228 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 246196018229 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 246196018230 SnoaL-like domain; Region: SnoaL_4; pfam13577 246196018231 hypothetical protein; Validated; Region: PRK07581 246196018232 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 246196018233 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246196018234 enoyl-CoA hydratase; Provisional; Region: PRK09245 246196018235 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196018236 substrate binding site [chemical binding]; other site 246196018237 oxyanion hole (OAH) forming residues; other site 246196018238 trimer interface [polypeptide binding]; other site 246196018239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246196018240 metabolite-proton symporter; Region: 2A0106; TIGR00883 246196018241 putative substrate translocation pore; other site 246196018242 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 246196018243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018244 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 246196018245 dimerization interface [polypeptide binding]; other site 246196018246 substrate binding pocket [chemical binding]; other site 246196018247 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196018248 enoyl-CoA hydratase; Provisional; Region: PRK05862 246196018249 substrate binding site [chemical binding]; other site 246196018250 oxyanion hole (OAH) forming residues; other site 246196018251 trimer interface [polypeptide binding]; other site 246196018252 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196018253 DinB superfamily; Region: DinB_2; cl19195 246196018254 TIGR03086 family protein; Region: TIGR03086 246196018255 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 246196018256 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 246196018257 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 246196018258 nucleophilic elbow; other site 246196018259 catalytic triad; other site 246196018260 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196018261 RibD C-terminal domain; Region: RibD_C; cl17279 246196018262 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 246196018263 substrate binding site [chemical binding]; other site 246196018264 dimer interface [polypeptide binding]; other site 246196018265 catalytic triad [active] 246196018266 ribose 5-phosphate isomerase; Region: RPI_actino; TIGR02133 246196018267 dihydroxyacetone kinase; Provisional; Region: PRK14479 246196018268 Dak1 domain; Region: Dak1; cl10557 246196018269 DAK2 domain; Region: Dak2; pfam02734 246196018270 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018272 DNA-binding site [nucleotide binding]; DNA binding site 246196018273 FCD domain; Region: FCD; pfam07729 246196018274 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 246196018275 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 246196018276 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246196018277 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246196018278 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246196018279 fructuronate transporter; Provisional; Region: PRK10034; cl15264 246196018280 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 246196018281 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 246196018282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246196018283 salt bridge; other site 246196018284 non-specific DNA binding site [nucleotide binding]; other site 246196018285 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246196018286 sequence-specific DNA binding site [nucleotide binding]; other site 246196018287 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246196018288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246196018289 substrate binding site [chemical binding]; other site 246196018290 oxyanion hole (OAH) forming residues; other site 246196018291 trimer interface [polypeptide binding]; other site 246196018292 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196018293 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 246196018294 Transcriptional regulators [Transcription]; Region: PurR; COG1609 246196018295 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 246196018296 DNA binding site [nucleotide binding] 246196018297 domain linker motif; other site 246196018298 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 246196018299 dimerization interface [polypeptide binding]; other site 246196018300 ligand binding site [chemical binding]; other site 246196018301 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 246196018302 active site 246196018303 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246196018304 substrate binding site [chemical binding]; other site 246196018305 ATP binding site [chemical binding]; other site 246196018306 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196018307 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246196018308 Walker A/P-loop; other site 246196018309 ATP binding site [chemical binding]; other site 246196018310 Q-loop/lid; other site 246196018311 ABC transporter signature motif; other site 246196018312 Walker B; other site 246196018313 D-loop; other site 246196018314 H-loop/switch region; other site 246196018315 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 246196018316 TM-ABC transporter signature motif; other site 246196018317 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 246196018318 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 246196018319 ligand binding site [chemical binding]; other site 246196018320 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196018321 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 246196018322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196018323 Walker A/P-loop; other site 246196018324 ATP binding site [chemical binding]; other site 246196018325 Q-loop/lid; other site 246196018326 ABC transporter signature motif; other site 246196018327 Walker B; other site 246196018328 D-loop; other site 246196018329 H-loop/switch region; other site 246196018330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246196018331 Walker A/P-loop; other site 246196018332 ATP binding site [chemical binding]; other site 246196018333 Q-loop/lid; other site 246196018334 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 246196018335 ABC transporter signature motif; other site 246196018336 Walker B; other site 246196018337 D-loop; other site 246196018338 H-loop/switch region; other site 246196018339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018340 MoxR-like ATPases [General function prediction only]; Region: COG0714 246196018341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196018342 Walker A motif; other site 246196018343 ATP binding site [chemical binding]; other site 246196018344 Walker B motif; other site 246196018345 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 246196018346 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 246196018347 Amidohydrolase; Region: Amidohydro_2; pfam04909 246196018348 active site 246196018349 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196018350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196018351 putative DNA binding site [nucleotide binding]; other site 246196018352 putative Zn2+ binding site [ion binding]; other site 246196018353 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 246196018354 active site 246196018355 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246196018356 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 246196018357 putative [4Fe-4S] binding site [ion binding]; other site 246196018358 putative molybdopterin cofactor binding site [chemical binding]; other site 246196018359 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 246196018360 molybdopterin cofactor binding site; other site 246196018361 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 246196018362 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196018363 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196018364 DNA binding residues [nucleotide binding] 246196018365 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196018366 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246196018367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196018368 Acylphosphatase; Region: Acylphosphatase; cl00551 246196018369 Survival protein SurE; Region: SurE; pfam01975 246196018370 Vinculin family; Region: Vinculin; pfam01044 246196018371 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 246196018372 short chain dehydrogenase; Provisional; Region: PRK06500 246196018373 classical (c) SDRs; Region: SDR_c; cd05233 246196018374 NAD(P) binding site [chemical binding]; other site 246196018375 active site 246196018376 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196018377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246196018378 putative DNA binding site [nucleotide binding]; other site 246196018379 putative Zn2+ binding site [ion binding]; other site 246196018380 CAAX protease self-immunity; Region: Abi; pfam02517 246196018381 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 246196018382 AAA ATPase domain; Region: AAA_16; pfam13191 246196018383 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246196018384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246196018385 DNA binding residues [nucleotide binding] 246196018386 dimerization interface [polypeptide binding]; other site 246196018387 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196018388 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196018389 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018390 TIGR03086 family protein; Region: TIGR03086 246196018391 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 246196018392 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196018393 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 246196018394 putative NAD(P) binding site [chemical binding]; other site 246196018395 putative substrate binding site [chemical binding]; other site 246196018396 catalytic Zn binding site [ion binding]; other site 246196018397 structural Zn binding site [ion binding]; other site 246196018398 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246196018399 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 246196018400 putative NAD(P) binding site [chemical binding]; other site 246196018401 putative substrate binding site [chemical binding]; other site 246196018402 catalytic Zn binding site [ion binding]; other site 246196018403 structural Zn binding site [ion binding]; other site 246196018404 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 246196018405 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246196018406 putative di-iron ligands [ion binding]; other site 246196018407 Glutaminase; Region: Glutaminase; cl00907 246196018408 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 246196018409 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246196018410 catalytic loop [active] 246196018411 iron binding site [ion binding]; other site 246196018412 Probable pheophorbidase; Region: PLN02965; cl17657 246196018413 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018414 haloalkane dehalogenase; Provisional; Region: PRK03592 246196018415 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 246196018416 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 246196018417 conserved cys residue [active] 246196018418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246196018419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196018421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246196018422 dimerization interface [polypeptide binding]; other site 246196018423 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 246196018424 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246196018425 inhibitor-cofactor binding pocket; inhibition site 246196018426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246196018427 catalytic residue [active] 246196018428 short chain dehydrogenase; Region: adh_short; pfam00106 246196018429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196018430 NAD(P) binding site [chemical binding]; other site 246196018431 active site 246196018432 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 246196018433 DctM-like transporters; Region: DctM; pfam06808 246196018434 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 246196018435 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 246196018436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196018437 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246196018438 NAD(P) binding site [chemical binding]; other site 246196018439 active site 246196018440 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 246196018441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196018442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018443 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 246196018444 putative dimerization interface [polypeptide binding]; other site 246196018445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018446 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196018447 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 246196018448 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246196018449 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 246196018450 substrate binding site [chemical binding]; other site 246196018451 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 246196018452 substrate binding site [chemical binding]; other site 246196018453 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246196018454 substrate binding site [chemical binding]; other site 246196018455 ligand binding site [chemical binding]; other site 246196018456 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246196018457 tetramer interface [polypeptide binding]; other site 246196018458 active site 246196018459 Mg2+/Mn2+ binding site [ion binding]; other site 246196018460 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 246196018461 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196018462 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196018463 Bacterial transcriptional regulator; Region: IclR; pfam01614 246196018464 Epoxide hydrolase N terminus; Region: EHN; pfam06441 246196018465 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246196018466 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246196018467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246196018468 NAD(P) binding site [chemical binding]; other site 246196018469 active site 246196018470 SnoaL-like domain; Region: SnoaL_2; pfam12680 246196018471 Cupin domain; Region: Cupin_2; pfam07883 246196018472 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 246196018473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246196018474 aldolase II superfamily protein; Provisional; Region: PRK07044 246196018475 intersubunit interface [polypeptide binding]; other site 246196018476 active site 246196018477 Zn2+ binding site [ion binding]; other site 246196018478 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246196018479 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246196018480 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246196018481 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 246196018482 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246196018483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196018484 dimer interface [polypeptide binding]; other site 246196018485 conserved gate region; other site 246196018486 putative PBP binding loops; other site 246196018487 ABC-ATPase subunit interface; other site 246196018488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246196018489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196018490 dimer interface [polypeptide binding]; other site 246196018491 conserved gate region; other site 246196018492 putative PBP binding loops; other site 246196018493 ABC-ATPase subunit interface; other site 246196018494 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246196018495 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246196018496 Creatinine amidohydrolase; Region: Creatininase; pfam02633 246196018497 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 246196018498 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 246196018499 metal binding site [ion binding]; metal-binding site 246196018500 substrate binding pocket [chemical binding]; other site 246196018501 Beta-lactamase; Region: Beta-lactamase; pfam00144 246196018502 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 246196018503 NAD(P) binding site [chemical binding]; other site 246196018504 catalytic residues [active] 246196018505 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246196018506 homotrimer interaction site [polypeptide binding]; other site 246196018507 putative active site [active] 246196018508 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246196018509 homotrimer interaction site [polypeptide binding]; other site 246196018510 putative active site [active] 246196018511 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246196018512 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246196018513 Walker A/P-loop; other site 246196018514 ATP binding site [chemical binding]; other site 246196018515 Q-loop/lid; other site 246196018516 ABC transporter signature motif; other site 246196018517 Walker B; other site 246196018518 D-loop; other site 246196018519 H-loop/switch region; other site 246196018520 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246196018521 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246196018522 Walker A/P-loop; other site 246196018523 ATP binding site [chemical binding]; other site 246196018524 Q-loop/lid; other site 246196018525 ABC transporter signature motif; other site 246196018526 Walker B; other site 246196018527 D-loop; other site 246196018528 H-loop/switch region; other site 246196018529 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246196018530 TM-ABC transporter signature motif; other site 246196018531 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246196018532 TM-ABC transporter signature motif; other site 246196018533 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 246196018534 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 246196018535 ligand binding site [chemical binding]; other site 246196018536 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018538 DNA-binding site [nucleotide binding]; DNA binding site 246196018539 FCD domain; Region: FCD; pfam07729 246196018540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246196018541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246196018542 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246196018543 dimerization interface [polypeptide binding]; other site 246196018544 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 246196018545 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 246196018546 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196018547 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196018548 Predicted transcriptional regulators [Transcription]; Region: COG1733 246196018549 putative DNA binding site [nucleotide binding]; other site 246196018550 dimerization interface [polypeptide binding]; other site 246196018551 putative Zn2+ binding site [ion binding]; other site 246196018552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196018553 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246196018554 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246196018555 active site 246196018556 putative transposase OrfB; Reviewed; Region: PHA02517 246196018557 Integrase core domain; Region: rve; pfam00665 246196018558 Integrase core domain; Region: rve_3; cl15866 246196018559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246196018560 Transposase; Region: HTH_Tnp_1; cl17663 246196018561 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 246196018562 replicative DNA helicase; Validated; Region: PRK07773 246196018563 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 246196018564 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 246196018565 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246196018566 Walker A motif; other site 246196018567 ATP binding site [chemical binding]; other site 246196018568 Walker B motif; other site 246196018569 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246196018570 protein-splicing catalytic site; other site 246196018571 thioester formation/cholesterol transfer; other site 246196018572 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 246196018573 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246196018574 protein-splicing catalytic site; other site 246196018575 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246196018576 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 246196018577 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 246196018578 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 246196018579 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 246196018580 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 246196018581 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 246196018582 dimer interface [polypeptide binding]; other site 246196018583 ssDNA binding site [nucleotide binding]; other site 246196018584 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246196018585 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 246196018586 Predicted integral membrane protein [Function unknown]; Region: COG5650 246196018587 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 246196018588 Transglycosylase; Region: Transgly; pfam00912 246196018589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246196018590 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 246196018591 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 246196018592 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 246196018593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246196018594 Putative lysophospholipase; Region: Hydrolase_4; cl19140 246196018595 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 246196018596 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 246196018597 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246196018598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246196018599 DNA-binding site [nucleotide binding]; DNA binding site 246196018600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246196018601 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246196018602 substrate binding pocket [chemical binding]; other site 246196018603 membrane-bound complex binding site; other site 246196018604 hinge residues; other site 246196018605 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 246196018606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246196018607 dimer interface [polypeptide binding]; other site 246196018608 conserved gate region; other site 246196018609 putative PBP binding loops; other site 246196018610 ABC-ATPase subunit interface; other site 246196018611 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246196018612 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246196018613 Walker A/P-loop; other site 246196018614 ATP binding site [chemical binding]; other site 246196018615 Q-loop/lid; other site 246196018616 ABC transporter signature motif; other site 246196018617 Walker B; other site 246196018618 D-loop; other site 246196018619 H-loop/switch region; other site 246196018620 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246196018621 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246196018622 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 246196018623 short chain dehydrogenase; Provisional; Region: PRK08219 246196018624 classical (c) SDRs; Region: SDR_c; cd05233 246196018625 NAD(P) binding site [chemical binding]; other site 246196018626 active site 246196018627 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 246196018628 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 246196018629 active site 246196018630 HIGH motif; other site 246196018631 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246196018632 KMSKS motif; other site 246196018633 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 246196018634 tRNA binding surface [nucleotide binding]; other site 246196018635 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 246196018636 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 246196018637 hydrogenase 4 subunit B; Validated; Region: PRK06521 246196018638 hypothetical protein; Validated; Region: PRK00228 246196018639 H+ Antiporter protein; Region: 2A0121; TIGR00900 246196018640 TIGR03084 family protein; Region: TIGR03084 246196018641 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 246196018642 Wyosine base formation; Region: Wyosine_form; pfam08608 246196018643 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 246196018644 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 246196018645 active site 246196018646 NTP binding site [chemical binding]; other site 246196018647 metal binding triad [ion binding]; metal-binding site 246196018648 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 246196018649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246196018650 Zn2+ binding site [ion binding]; other site 246196018651 Mg2+ binding site [ion binding]; other site 246196018652 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 246196018653 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 246196018654 active site 246196018655 Ap6A binding site [chemical binding]; other site 246196018656 nudix motif; other site 246196018657 metal binding site [ion binding]; metal-binding site 246196018658 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 246196018659 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 246196018660 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246196018661 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 246196018662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246196018663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246196018664 DNA binding residues [nucleotide binding] 246196018665 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 246196018666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 246196018667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246196018668 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246196018669 catalytic residues [active] 246196018670 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 246196018671 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246196018672 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246196018673 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246196018674 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246196018675 active site 246196018676 metal binding site [ion binding]; metal-binding site 246196018677 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 246196018678 ParB-like nuclease domain; Region: ParBc; pfam02195 246196018679 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246196018680 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246196018681 P-loop; other site 246196018682 Magnesium ion binding site [ion binding]; other site 246196018683 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 246196018684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246196018685 S-adenosylmethionine binding site [chemical binding]; other site 246196018686 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 246196018687 G-X-X-G motif; other site 246196018688 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 246196018689 RxxxH motif; other site 246196018690 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 246196018691 hypothetical protein; Validated; Region: PRK00041 246196018692 Ribonuclease P; Region: Ribonuclease_P; cl00457 246196018693 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 246196018694 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 246196018695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246196018696 Walker A motif; other site 246196018697 ATP binding site [chemical binding]; other site 246196018698 Walker B motif; other site 246196018699 arginine finger; other site 246196018700 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 246196018701 DnaA box-binding interface [nucleotide binding]; other site