-- dump date 20140619_153821 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1306400000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1306400000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400000003 Walker A motif; other site 1306400000004 ATP binding site [chemical binding]; other site 1306400000005 Walker B motif; other site 1306400000006 arginine finger; other site 1306400000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1306400000008 DnaA box-binding interface [nucleotide binding]; other site 1306400000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1306400000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1306400000011 putative DNA binding surface [nucleotide binding]; other site 1306400000012 dimer interface [polypeptide binding]; other site 1306400000013 beta-clamp/clamp loader binding surface; other site 1306400000014 beta-clamp/translesion DNA polymerase binding surface; other site 1306400000015 recF protein; Region: recf; TIGR00611 1306400000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1306400000017 Walker A/P-loop; other site 1306400000018 ATP binding site [chemical binding]; other site 1306400000019 Q-loop/lid; other site 1306400000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400000021 ABC transporter signature motif; other site 1306400000022 Walker B; other site 1306400000023 D-loop; other site 1306400000024 H-loop/switch region; other site 1306400000025 hypothetical protein; Provisional; Region: PRK03195 1306400000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1306400000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400000028 Mg2+ binding site [ion binding]; other site 1306400000029 G-X-G motif; other site 1306400000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1306400000031 anchoring element; other site 1306400000032 dimer interface [polypeptide binding]; other site 1306400000033 ATP binding site [chemical binding]; other site 1306400000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1306400000035 active site 1306400000036 putative metal-binding site [ion binding]; other site 1306400000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1306400000038 DNA gyrase subunit A; Validated; Region: PRK05560 1306400000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1306400000040 CAP-like domain; other site 1306400000041 active site 1306400000042 primary dimer interface [polypeptide binding]; other site 1306400000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306400000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306400000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306400000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306400000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306400000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1306400000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1306400000050 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1306400000051 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1306400000052 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1306400000053 active site 1306400000054 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1306400000055 putative septation inhibitor protein; Reviewed; Region: PRK00159 1306400000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1306400000057 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1306400000058 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1306400000059 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1306400000060 glutamine binding [chemical binding]; other site 1306400000061 catalytic triad [active] 1306400000062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400000063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400000064 active site 1306400000065 ATP binding site [chemical binding]; other site 1306400000066 substrate binding site [chemical binding]; other site 1306400000067 activation loop (A-loop); other site 1306400000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1306400000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306400000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306400000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306400000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306400000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400000074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400000075 active site 1306400000076 ATP binding site [chemical binding]; other site 1306400000077 substrate binding site [chemical binding]; other site 1306400000078 activation loop (A-loop); other site 1306400000079 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1306400000080 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1306400000081 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1306400000082 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1306400000083 active site 1306400000084 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306400000085 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306400000086 phosphopeptide binding site; other site 1306400000087 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1306400000088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306400000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306400000090 phosphopeptide binding site; other site 1306400000091 Nitronate monooxygenase; Region: NMO; pfam03060 1306400000092 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306400000093 FMN binding site [chemical binding]; other site 1306400000094 substrate binding site [chemical binding]; other site 1306400000095 putative catalytic residue [active] 1306400000096 Transcription factor WhiB; Region: Whib; pfam02467 1306400000097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306400000098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400000099 non-specific DNA binding site [nucleotide binding]; other site 1306400000100 salt bridge; other site 1306400000101 sequence-specific DNA binding site [nucleotide binding]; other site 1306400000102 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306400000103 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306400000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1306400000105 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1306400000106 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1306400000107 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1306400000108 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1306400000109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1306400000110 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1306400000111 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1306400000112 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400000113 catalytic residue [active] 1306400000114 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1306400000115 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1306400000116 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1306400000117 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400000118 acyl-activating enzyme (AAE) consensus motif; other site 1306400000119 active site 1306400000120 TIGR03084 family protein; Region: TIGR03084 1306400000121 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1306400000122 Wyosine base formation; Region: Wyosine_form; pfam08608 1306400000123 H+ Antiporter protein; Region: 2A0121; TIGR00900 1306400000124 hypothetical protein; Validated; Region: PRK00228 1306400000125 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1306400000126 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1306400000127 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306400000128 active site 1306400000129 HIGH motif; other site 1306400000130 nucleotide binding site [chemical binding]; other site 1306400000131 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1306400000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306400000133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306400000134 active site 1306400000135 KMSKS motif; other site 1306400000136 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1306400000137 tRNA binding surface [nucleotide binding]; other site 1306400000138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306400000139 MarR family; Region: MarR; pfam01047 1306400000140 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306400000141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306400000142 DNA-binding site [nucleotide binding]; DNA binding site 1306400000143 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1306400000144 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400000145 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1306400000146 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1306400000147 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1306400000148 Predicted transcriptional regulators [Transcription]; Region: COG1695 1306400000149 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1306400000150 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1306400000151 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1306400000152 Transglycosylase; Region: Transgly; pfam00912 1306400000153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1306400000154 Predicted integral membrane protein [Function unknown]; Region: COG5650 1306400000155 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1306400000156 conserved cys residue [active] 1306400000157 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1306400000158 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1306400000159 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1306400000160 dimer interface [polypeptide binding]; other site 1306400000161 ssDNA binding site [nucleotide binding]; other site 1306400000162 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1306400000163 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1306400000164 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1306400000165 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1306400000166 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1306400000167 replicative DNA helicase; Validated; Region: PRK07773 1306400000168 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1306400000169 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1306400000170 Walker A motif; other site 1306400000171 ATP binding site [chemical binding]; other site 1306400000172 Walker B motif; other site 1306400000173 DNA binding loops [nucleotide binding] 1306400000174 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1306400000175 protein-splicing catalytic site; other site 1306400000176 thioester formation/cholesterol transfer; other site 1306400000177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1306400000178 protein-splicing catalytic site; other site 1306400000179 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1306400000180 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1306400000181 ADP-ribose binding site [chemical binding]; other site 1306400000182 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1306400000183 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 1306400000184 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1306400000185 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400000186 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400000187 Berberine and berberine like; Region: BBE; pfam08031 1306400000188 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1306400000189 hypothetical protein; Validated; Region: PRK00068 1306400000190 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1306400000191 homotetrameric interface [polypeptide binding]; other site 1306400000192 putative active site [active] 1306400000193 metal binding site [ion binding]; metal-binding site 1306400000194 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1306400000195 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1306400000196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000198 short chain dehydrogenase; Provisional; Region: PRK06197 1306400000199 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1306400000200 putative NAD(P) binding site [chemical binding]; other site 1306400000201 active site 1306400000202 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1306400000203 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1306400000204 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1306400000205 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1306400000206 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1306400000207 dimer interface [polypeptide binding]; other site 1306400000208 active site 1306400000209 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1306400000210 folate binding site [chemical binding]; other site 1306400000211 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1306400000212 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1306400000213 putative NTP binding site [chemical binding]; other site 1306400000214 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1306400000215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1306400000216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1306400000217 Walker A/P-loop; other site 1306400000218 ATP binding site [chemical binding]; other site 1306400000219 Q-loop/lid; other site 1306400000220 ABC transporter signature motif; other site 1306400000221 Walker B; other site 1306400000222 D-loop; other site 1306400000223 H-loop/switch region; other site 1306400000224 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306400000225 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306400000226 ligand binding site [chemical binding]; other site 1306400000227 flexible hinge region; other site 1306400000228 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1306400000229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1306400000230 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1306400000231 active site 1306400000232 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1306400000233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400000234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400000235 homodimer interface [polypeptide binding]; other site 1306400000236 catalytic residue [active] 1306400000237 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400000238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000240 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1306400000241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400000242 dimerization interface [polypeptide binding]; other site 1306400000243 putative DNA binding site [nucleotide binding]; other site 1306400000244 putative Zn2+ binding site [ion binding]; other site 1306400000245 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1306400000246 hydrogenase 4 subunit B; Validated; Region: PRK06521 1306400000247 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306400000248 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1306400000249 NADH dehydrogenase; Region: NADHdh; cl00469 1306400000250 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1306400000251 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306400000252 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1306400000253 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1306400000254 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1306400000255 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1306400000256 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1306400000257 putative hydrophobic ligand binding site [chemical binding]; other site 1306400000258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400000259 S-adenosylmethionine binding site [chemical binding]; other site 1306400000260 Predicted membrane protein [Function unknown]; Region: COG3305 1306400000261 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1306400000262 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1306400000263 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1306400000264 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1306400000265 metal-binding site [ion binding] 1306400000266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400000267 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306400000268 Predicted integral membrane protein [Function unknown]; Region: COG5660 1306400000269 Putative zinc-finger; Region: zf-HC2; pfam13490 1306400000270 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400000271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400000272 active site 1306400000273 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400000274 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000275 PPE family; Region: PPE; pfam00823 1306400000276 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1306400000277 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1306400000278 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1306400000279 acyl-CoA synthetase; Validated; Region: PRK05857 1306400000280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400000281 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1306400000282 acyl-activating enzyme (AAE) consensus motif; other site 1306400000283 acyl-activating enzyme (AAE) consensus motif; other site 1306400000284 AMP binding site [chemical binding]; other site 1306400000285 active site 1306400000286 CoA binding site [chemical binding]; other site 1306400000287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306400000288 AMP-binding enzyme; Region: AMP-binding; pfam00501 1306400000289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400000290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400000291 acyl-activating enzyme (AAE) consensus motif; other site 1306400000292 acyl-activating enzyme (AAE) consensus motif; other site 1306400000293 active site 1306400000294 AMP binding site [chemical binding]; other site 1306400000295 CoA binding site [chemical binding]; other site 1306400000296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306400000297 Condensation domain; Region: Condensation; pfam00668 1306400000298 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306400000299 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1306400000300 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1306400000301 acyl-activating enzyme (AAE) consensus motif; other site 1306400000302 AMP binding site [chemical binding]; other site 1306400000303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306400000304 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1306400000305 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1306400000306 putative NAD(P) binding site [chemical binding]; other site 1306400000307 active site 1306400000308 putative substrate binding site [chemical binding]; other site 1306400000309 Predicted membrane protein [Function unknown]; Region: COG3336 1306400000310 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1306400000311 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1306400000312 metal-binding site [ion binding] 1306400000313 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400000314 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306400000315 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1306400000316 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306400000317 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306400000318 ligand binding site [chemical binding]; other site 1306400000319 flexible hinge region; other site 1306400000320 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1306400000321 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1306400000322 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1306400000323 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1306400000324 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400000325 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1306400000326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400000327 motif II; other site 1306400000328 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1306400000329 PE family; Region: PE; pfam00934 1306400000330 Rhomboid family; Region: Rhomboid; pfam01694 1306400000331 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1306400000332 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1306400000333 active site 1306400000334 catalytic triad [active] 1306400000335 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306400000336 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1306400000337 NADP-binding site; other site 1306400000338 homotetramer interface [polypeptide binding]; other site 1306400000339 substrate binding site [chemical binding]; other site 1306400000340 homodimer interface [polypeptide binding]; other site 1306400000341 active site 1306400000342 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1306400000343 dimer interface [polypeptide binding]; other site 1306400000344 active site 1306400000345 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1306400000346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400000347 active site 1306400000348 motif I; other site 1306400000349 motif II; other site 1306400000350 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1306400000351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306400000352 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306400000353 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306400000354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1306400000355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306400000356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1306400000357 dimerization interface [polypeptide binding]; other site 1306400000358 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1306400000359 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306400000360 PYR/PP interface [polypeptide binding]; other site 1306400000361 dimer interface [polypeptide binding]; other site 1306400000362 TPP binding site [chemical binding]; other site 1306400000363 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306400000364 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1306400000365 TPP-binding site; other site 1306400000366 dimer interface [polypeptide binding]; other site 1306400000367 acyl-CoA synthetase; Validated; Region: PRK05852 1306400000368 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400000369 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1306400000370 acyl-activating enzyme (AAE) consensus motif; other site 1306400000371 acyl-activating enzyme (AAE) consensus motif; other site 1306400000372 putative AMP binding site [chemical binding]; other site 1306400000373 putative active site [active] 1306400000374 putative CoA binding site [chemical binding]; other site 1306400000375 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1306400000376 elongation factor G; Reviewed; Region: PRK12740 1306400000377 G1 box; other site 1306400000378 putative GEF interaction site [polypeptide binding]; other site 1306400000379 GTP/Mg2+ binding site [chemical binding]; other site 1306400000380 Switch I region; other site 1306400000381 G2 box; other site 1306400000382 G3 box; other site 1306400000383 Switch II region; other site 1306400000384 G4 box; other site 1306400000385 G5 box; other site 1306400000386 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1306400000387 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1306400000388 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1306400000389 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1306400000390 PE family; Region: PE; pfam00934 1306400000391 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1306400000392 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306400000393 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1306400000394 trehalose synthase; Region: treS_nterm; TIGR02456 1306400000395 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1306400000396 active site 1306400000397 catalytic site [active] 1306400000398 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1306400000399 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1306400000400 Predicted membrane protein [Function unknown]; Region: COG3619 1306400000401 Predicted esterase [General function prediction only]; Region: COG0627 1306400000402 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1306400000403 putative active site [active] 1306400000404 putative catalytic site [active] 1306400000405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400000406 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400000407 active site 1306400000408 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1306400000409 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400000410 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1306400000411 Coenzyme A binding pocket [chemical binding]; other site 1306400000412 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1306400000413 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306400000414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000416 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400000417 Cytochrome P450; Region: p450; cl12078 1306400000418 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1306400000419 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306400000420 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1306400000421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400000422 NAD(P) binding site [chemical binding]; other site 1306400000423 active site 1306400000424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1306400000425 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1306400000426 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1306400000427 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1306400000428 minor groove reading motif; other site 1306400000429 helix-hairpin-helix signature motif; other site 1306400000430 active site 1306400000431 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1306400000432 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1306400000433 Cl- selectivity filter; other site 1306400000434 Cl- binding residues [ion binding]; other site 1306400000435 pore gating glutamate residue; other site 1306400000436 dimer interface [polypeptide binding]; other site 1306400000437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000439 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400000440 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400000441 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400000442 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400000443 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1306400000444 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1306400000445 NAD(P) binding site [chemical binding]; other site 1306400000446 catalytic residues [active] 1306400000447 short chain dehydrogenase; Provisional; Region: PRK07791 1306400000448 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1306400000449 NAD binding site [chemical binding]; other site 1306400000450 homodimer interface [polypeptide binding]; other site 1306400000451 active site 1306400000452 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1306400000453 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1306400000454 NAD(P) binding site [chemical binding]; other site 1306400000455 PE family; Region: PE; pfam00934 1306400000456 PE-PPE domain; Region: PE-PPE; pfam08237 1306400000457 PE-PPE domain; Region: PE-PPE; pfam08237 1306400000458 PE family; Region: PE; pfam00934 1306400000459 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1306400000460 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1306400000461 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1306400000462 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1306400000463 FAD binding site [chemical binding]; other site 1306400000464 substrate binding site [chemical binding]; other site 1306400000465 catalytic base [active] 1306400000466 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1306400000467 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1306400000468 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1306400000469 ligand binding site [chemical binding]; other site 1306400000470 homodimer interface [polypeptide binding]; other site 1306400000471 NAD(P) binding site [chemical binding]; other site 1306400000472 trimer interface B [polypeptide binding]; other site 1306400000473 trimer interface A [polypeptide binding]; other site 1306400000474 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1306400000475 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1306400000476 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1306400000477 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1306400000478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000480 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1306400000481 PE-PPE domain; Region: PE-PPE; pfam08237 1306400000482 PE family; Region: PE; pfam00934 1306400000483 PE family; Region: PE; pfam00934 1306400000484 PE-PPE domain; Region: PE-PPE; pfam08237 1306400000485 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400000486 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400000487 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1306400000488 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306400000489 NAD(P) binding site [chemical binding]; other site 1306400000490 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1306400000491 active site 1306400000492 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306400000493 putative hydrophobic ligand binding site [chemical binding]; other site 1306400000494 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1306400000495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306400000496 DNA-binding site [nucleotide binding]; DNA binding site 1306400000497 FCD domain; Region: FCD; pfam07729 1306400000498 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1306400000499 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400000500 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1306400000501 acyl-activating enzyme (AAE) consensus motif; other site 1306400000502 acyl-activating enzyme (AAE) consensus motif; other site 1306400000503 putative AMP binding site [chemical binding]; other site 1306400000504 putative active site [active] 1306400000505 putative CoA binding site [chemical binding]; other site 1306400000506 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306400000507 Permease; Region: Permease; pfam02405 1306400000508 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306400000509 Permease; Region: Permease; pfam02405 1306400000510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400000511 mce related protein; Region: MCE; pfam02470 1306400000512 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306400000513 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400000514 mce related protein; Region: MCE; pfam02470 1306400000515 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306400000516 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400000517 mce related protein; Region: MCE; pfam02470 1306400000518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400000519 mce related protein; Region: MCE; pfam02470 1306400000520 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400000521 mce related protein; Region: MCE; pfam02470 1306400000522 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400000523 mce related protein; Region: MCE; pfam02470 1306400000524 RDD family; Region: RDD; pfam06271 1306400000525 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1306400000526 Predicted membrane protein [Function unknown]; Region: COG1511 1306400000527 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1306400000528 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1306400000529 Pirin-related protein [General function prediction only]; Region: COG1741 1306400000530 Pirin; Region: Pirin; pfam02678 1306400000531 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1306400000532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400000533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400000534 DNA binding residues [nucleotide binding] 1306400000535 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306400000536 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1306400000537 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306400000538 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1306400000539 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1306400000540 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1306400000541 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1306400000542 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1306400000543 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1306400000544 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1306400000545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400000546 S-adenosylmethionine binding site [chemical binding]; other site 1306400000547 SPW repeat; Region: SPW; pfam03779 1306400000548 SPW repeat; Region: SPW; pfam03779 1306400000549 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1306400000550 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1306400000551 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1306400000552 putative homodimer interface [polypeptide binding]; other site 1306400000553 putative homotetramer interface [polypeptide binding]; other site 1306400000554 putative allosteric switch controlling residues; other site 1306400000555 putative metal binding site [ion binding]; other site 1306400000556 putative homodimer-homodimer interface [polypeptide binding]; other site 1306400000557 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1306400000558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400000559 putative substrate translocation pore; other site 1306400000560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306400000561 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306400000562 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306400000563 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1306400000564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1306400000565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400000566 Walker A/P-loop; other site 1306400000567 ATP binding site [chemical binding]; other site 1306400000568 Q-loop/lid; other site 1306400000569 ABC transporter signature motif; other site 1306400000570 Walker B; other site 1306400000571 D-loop; other site 1306400000572 H-loop/switch region; other site 1306400000573 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1306400000574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400000575 Walker A/P-loop; other site 1306400000576 ATP binding site [chemical binding]; other site 1306400000577 Q-loop/lid; other site 1306400000578 ABC transporter signature motif; other site 1306400000579 Walker B; other site 1306400000580 D-loop; other site 1306400000581 H-loop/switch region; other site 1306400000582 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306400000583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306400000584 dimerization interface [polypeptide binding]; other site 1306400000585 DNA binding residues [nucleotide binding] 1306400000586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000588 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1306400000589 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1306400000590 putative [Fe4-S4] binding site [ion binding]; other site 1306400000591 putative molybdopterin cofactor binding site [chemical binding]; other site 1306400000592 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306400000593 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1306400000594 putative molybdopterin cofactor binding site; other site 1306400000595 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1306400000596 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1306400000597 active site 1306400000598 Zn binding site [ion binding]; other site 1306400000599 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306400000600 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1306400000601 Predicted integral membrane protein [Function unknown]; Region: COG0392 1306400000602 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1306400000603 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1306400000604 MMPL family; Region: MMPL; pfam03176 1306400000605 MMPL family; Region: MMPL; pfam03176 1306400000606 LabA_like proteins; Region: LabA_like; cd06167 1306400000607 putative metal binding site [ion binding]; other site 1306400000608 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1306400000609 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1306400000610 active site 1306400000611 substrate-binding site [chemical binding]; other site 1306400000612 metal-binding site [ion binding] 1306400000613 GTP binding site [chemical binding]; other site 1306400000614 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1306400000615 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1306400000616 active site 1306400000617 (T/H)XGH motif; other site 1306400000618 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1306400000619 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1306400000620 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1306400000621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400000622 FeS/SAM binding site; other site 1306400000623 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1306400000624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400000625 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1306400000626 acyl-activating enzyme (AAE) consensus motif; other site 1306400000627 acyl-activating enzyme (AAE) consensus motif; other site 1306400000628 putative AMP binding site [chemical binding]; other site 1306400000629 putative active site [active] 1306400000630 putative CoA binding site [chemical binding]; other site 1306400000631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400000632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400000633 active site 1306400000634 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1306400000635 putative active site [active] 1306400000636 putative catalytic site [active] 1306400000637 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306400000638 active site 2 [active] 1306400000639 active site 1 [active] 1306400000640 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400000641 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400000642 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1306400000643 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1306400000644 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1306400000645 Moco binding site; other site 1306400000646 metal coordination site [ion binding]; other site 1306400000647 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400000648 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306400000649 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400000650 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400000651 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1306400000652 enoyl-CoA hydratase; Provisional; Region: PRK08252 1306400000653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400000654 substrate binding site [chemical binding]; other site 1306400000655 oxyanion hole (OAH) forming residues; other site 1306400000656 trimer interface [polypeptide binding]; other site 1306400000657 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1306400000658 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1306400000659 NAD binding site [chemical binding]; other site 1306400000660 catalytic residues [active] 1306400000661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400000662 S-adenosylmethionine binding site [chemical binding]; other site 1306400000663 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306400000664 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306400000665 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1306400000666 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1306400000667 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306400000668 putative active site [active] 1306400000669 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1306400000670 active site 1306400000671 substrate binding pocket [chemical binding]; other site 1306400000672 homodimer interaction site [polypeptide binding]; other site 1306400000673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400000674 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1306400000675 active site 1306400000676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000678 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1306400000679 active site 1306400000680 diiron metal binding site [ion binding]; other site 1306400000681 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1306400000682 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1306400000683 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1306400000684 NAD(P) binding site [chemical binding]; other site 1306400000685 catalytic residues [active] 1306400000686 Lipase maturation factor; Region: LMF1; pfam06762 1306400000687 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1306400000688 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1306400000689 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1306400000690 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1306400000691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000693 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400000694 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306400000695 MaoC like domain; Region: MaoC_dehydratas; pfam01575 1306400000696 active site 2 [active] 1306400000697 active site 1 [active] 1306400000698 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1306400000699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400000700 NAD(P) binding site [chemical binding]; other site 1306400000701 active site 1306400000702 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1306400000703 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306400000704 dimer interface [polypeptide binding]; other site 1306400000705 active site 1306400000706 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1306400000707 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1306400000708 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1306400000709 FAD binding site [chemical binding]; other site 1306400000710 substrate binding site [chemical binding]; other site 1306400000711 catalytic residues [active] 1306400000712 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1306400000713 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1306400000714 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1306400000715 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306400000716 catalytic loop [active] 1306400000717 iron binding site [ion binding]; other site 1306400000718 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1306400000719 L-aspartate oxidase; Provisional; Region: PRK06175 1306400000720 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1306400000721 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1306400000722 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1306400000723 putative dimer interface [polypeptide binding]; other site 1306400000724 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1306400000725 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400000726 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1306400000727 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1306400000728 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1306400000729 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1306400000730 homotrimer interface [polypeptide binding]; other site 1306400000731 Walker A motif; other site 1306400000732 GTP binding site [chemical binding]; other site 1306400000733 Walker B motif; other site 1306400000734 cobyric acid synthase; Provisional; Region: PRK00784 1306400000735 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1306400000736 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1306400000737 catalytic triad [active] 1306400000738 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000739 PPE family; Region: PPE; pfam00823 1306400000740 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1306400000741 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1306400000742 putative active site [active] 1306400000743 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1306400000744 putative active site [active] 1306400000745 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1306400000746 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1306400000747 active site 1306400000748 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1306400000749 DNA binding site [nucleotide binding] 1306400000750 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1306400000751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400000752 Coenzyme A binding pocket [chemical binding]; other site 1306400000753 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1306400000754 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1306400000755 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1306400000756 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1306400000757 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1306400000758 intersubunit interface [polypeptide binding]; other site 1306400000759 potential frameshift: common BLAST hit: gi|471336075|ref|YP_007608788.1| 5-oxoprolinase 1306400000760 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1306400000761 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1306400000762 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1306400000763 nucleotide binding site [chemical binding]; other site 1306400000764 acyl-CoA synthetase; Validated; Region: PRK07788 1306400000765 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400000766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400000767 active site 1306400000768 CoA binding site [chemical binding]; other site 1306400000769 AMP binding site [chemical binding]; other site 1306400000770 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400000771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400000772 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1306400000773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400000774 FAD binding site [chemical binding]; other site 1306400000775 substrate binding site [chemical binding]; other site 1306400000776 catalytic base [active] 1306400000777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306400000778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000780 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1306400000781 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400000782 Zn binding site [ion binding]; other site 1306400000783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1306400000784 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400000785 putative active site [active] 1306400000786 PE family; Region: PE; pfam00934 1306400000787 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000788 PPE family; Region: PPE; pfam00823 1306400000789 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000790 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400000791 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400000792 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1306400000793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400000794 Walker A motif; other site 1306400000795 ATP binding site [chemical binding]; other site 1306400000796 Walker B motif; other site 1306400000797 arginine finger; other site 1306400000798 Protein of unknown function (DUF690); Region: DUF690; cl04939 1306400000799 potential frameshift: common BLAST hit: gi|397672074|ref|YP_006513609.1| ESX-3 secretion system protein eccB3 1306400000800 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306400000801 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400000802 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306400000803 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400000804 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400000805 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000806 PPE family; Region: PPE; pfam00823 1306400000807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306400000808 EspG family; Region: ESX-1_EspG; pfam14011 1306400000809 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306400000810 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306400000811 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1306400000812 active site 1306400000813 catalytic residues [active] 1306400000814 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1306400000815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306400000816 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1306400000817 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1306400000818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400000819 S-adenosylmethionine binding site [chemical binding]; other site 1306400000820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1306400000821 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306400000822 Sulfatase; Region: Sulfatase; cl17466 1306400000823 PE family; Region: PE; pfam00934 1306400000824 hypothetical protein; Region: PHA01748 1306400000825 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306400000826 putative active site [active] 1306400000827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000829 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1306400000830 protochlorophyllide reductase; Region: PLN00015 1306400000831 putative NAD(P) binding site [chemical binding]; other site 1306400000832 active site 1306400000833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000834 PPE family; Region: PPE; pfam00823 1306400000835 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000836 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400000837 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000838 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400000839 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400000840 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000841 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400000843 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400000844 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400000845 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400000846 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400000847 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1306400000848 putative FMN binding site [chemical binding]; other site 1306400000849 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1306400000850 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1306400000851 active site 1306400000852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1306400000853 SnoaL-like domain; Region: SnoaL_4; pfam13577 1306400000854 SnoaL-like domain; Region: SnoaL_3; pfam13474 1306400000855 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1306400000856 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306400000857 nucleotide binding site [chemical binding]; other site 1306400000858 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1306400000859 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1306400000860 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1306400000861 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1306400000862 active site 1306400000863 catalytic residues [active] 1306400000864 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1306400000865 Muconolactone delta-isomerase; Region: MIase; cl01992 1306400000866 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1306400000867 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1306400000868 putative active site [active] 1306400000869 catalytic site [active] 1306400000870 putative metal binding site [ion binding]; other site 1306400000871 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1306400000872 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1306400000873 putative substrate binding pocket [chemical binding]; other site 1306400000874 AC domain interface; other site 1306400000875 catalytic triad [active] 1306400000876 AB domain interface; other site 1306400000877 interchain disulfide; other site 1306400000878 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1306400000879 trimer interface [polypeptide binding]; other site 1306400000880 active site 1306400000881 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1306400000882 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1306400000883 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1306400000884 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1306400000885 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1306400000886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400000887 dimerization interface [polypeptide binding]; other site 1306400000888 putative DNA binding site [nucleotide binding]; other site 1306400000889 putative Zn2+ binding site [ion binding]; other site 1306400000890 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1306400000891 active site residue [active] 1306400000892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400000893 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400000894 Cytochrome P450; Region: p450; cl12078 1306400000895 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1306400000896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000897 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1306400000898 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400000899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400000900 S-adenosylmethionine binding site [chemical binding]; other site 1306400000901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400000902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400000903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1306400000904 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306400000905 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1306400000906 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306400000907 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1306400000908 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1306400000909 substrate binding site; other site 1306400000910 tetramer interface; other site 1306400000911 PE family; Region: PE; pfam00934 1306400000912 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400000913 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400000914 active site 1306400000915 aminotransferase AlaT; Validated; Region: PRK09265 1306400000916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400000917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400000918 homodimer interface [polypeptide binding]; other site 1306400000919 catalytic residue [active] 1306400000920 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1306400000921 4Fe-4S binding domain; Region: Fer4; pfam00037 1306400000922 Cysteine-rich domain; Region: CCG; pfam02754 1306400000923 Cysteine-rich domain; Region: CCG; pfam02754 1306400000924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306400000925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306400000926 DNA binding residues [nucleotide binding] 1306400000927 dimerization interface [polypeptide binding]; other site 1306400000928 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1306400000929 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1306400000930 G1 box; other site 1306400000931 GTP/Mg2+ binding site [chemical binding]; other site 1306400000932 G2 box; other site 1306400000933 Switch I region; other site 1306400000934 G3 box; other site 1306400000935 Switch II region; other site 1306400000936 G4 box; other site 1306400000937 G5 box; other site 1306400000938 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1306400000939 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1306400000940 G1 box; other site 1306400000941 GTP/Mg2+ binding site [chemical binding]; other site 1306400000942 G2 box; other site 1306400000943 Switch I region; other site 1306400000944 G3 box; other site 1306400000945 Switch II region; other site 1306400000946 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 1306400000947 active site 1306400000948 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1306400000949 TIGR04255 family protein; Region: sporadTIGR04255 1306400000950 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1306400000951 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1306400000952 nucleotide binding site [chemical binding]; other site 1306400000953 NEF interaction site [polypeptide binding]; other site 1306400000954 SBD interface [polypeptide binding]; other site 1306400000955 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1306400000956 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1306400000957 dimer interface [polypeptide binding]; other site 1306400000958 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1306400000959 chaperone protein DnaJ; Provisional; Region: PRK14279 1306400000960 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1306400000961 HSP70 interaction site [polypeptide binding]; other site 1306400000962 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1306400000963 Zn binding sites [ion binding]; other site 1306400000964 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1306400000965 dimer interface [polypeptide binding]; other site 1306400000966 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1306400000967 DNA binding residues [nucleotide binding] 1306400000968 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1306400000969 putative dimer interface [polypeptide binding]; other site 1306400000970 potential frameshift: common BLAST hit: gi|448824742|ref|YP_177721.2| PPE family protein PPE8 1306400000971 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1306400000972 CoenzymeA binding site [chemical binding]; other site 1306400000973 subunit interaction site [polypeptide binding]; other site 1306400000974 PHB binding site; other site 1306400000975 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1306400000976 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1306400000977 GDP-binding site [chemical binding]; other site 1306400000978 ACT binding site; other site 1306400000979 IMP binding site; other site 1306400000980 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1306400000981 Peptidase family M50; Region: Peptidase_M50; pfam02163 1306400000982 active site 1306400000983 putative substrate binding region [chemical binding]; other site 1306400000984 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1306400000985 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1306400000986 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1306400000987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1306400000988 Divalent cation transporter; Region: MgtE; pfam01769 1306400000989 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1306400000990 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1306400000991 active site 1306400000992 intersubunit interface [polypeptide binding]; other site 1306400000993 zinc binding site [ion binding]; other site 1306400000994 Na+ binding site [ion binding]; other site 1306400000995 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1306400000996 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1306400000997 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1306400000998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1306400000999 AAA domain; Region: AAA_33; pfam13671 1306400001000 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1306400001001 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1306400001002 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1306400001003 metal ion-dependent adhesion site (MIDAS); other site 1306400001004 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1306400001005 putative hydrophobic ligand binding site [chemical binding]; other site 1306400001006 MoxR-like ATPases [General function prediction only]; Region: COG0714 1306400001007 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1306400001008 Ligand binding site; other site 1306400001009 metal-binding site 1306400001010 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1306400001011 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1306400001012 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1306400001013 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1306400001014 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1306400001015 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1306400001016 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1306400001017 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306400001018 catalytic loop [active] 1306400001019 iron binding site [ion binding]; other site 1306400001020 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1306400001021 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1306400001022 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1306400001023 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1306400001024 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1306400001025 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1306400001026 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1306400001027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1306400001028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306400001029 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1306400001030 dimerization interface [polypeptide binding]; other site 1306400001031 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1306400001032 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1306400001033 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1306400001034 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400001035 active site 1306400001036 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1306400001037 Clp amino terminal domain; Region: Clp_N; pfam02861 1306400001038 Clp amino terminal domain; Region: Clp_N; pfam02861 1306400001039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400001040 Walker A motif; other site 1306400001041 ATP binding site [chemical binding]; other site 1306400001042 Walker B motif; other site 1306400001043 arginine finger; other site 1306400001044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400001045 Walker A motif; other site 1306400001046 ATP binding site [chemical binding]; other site 1306400001047 Walker B motif; other site 1306400001048 arginine finger; other site 1306400001049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1306400001050 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1306400001051 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1306400001052 heme-binding site [chemical binding]; other site 1306400001053 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1306400001054 FAD binding pocket [chemical binding]; other site 1306400001055 FAD binding motif [chemical binding]; other site 1306400001056 phosphate binding motif [ion binding]; other site 1306400001057 beta-alpha-beta structure motif; other site 1306400001058 NAD binding pocket [chemical binding]; other site 1306400001059 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400001060 cyclase homology domain; Region: CHD; cd07302 1306400001061 nucleotidyl binding site; other site 1306400001062 metal binding site [ion binding]; metal-binding site 1306400001063 dimer interface [polypeptide binding]; other site 1306400001064 Predicted ATPase [General function prediction only]; Region: COG3903 1306400001065 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1306400001066 Walker A motif; other site 1306400001067 ATP binding site [chemical binding]; other site 1306400001068 Walker B motif; other site 1306400001069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306400001070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306400001071 DNA binding residues [nucleotide binding] 1306400001072 dimerization interface [polypeptide binding]; other site 1306400001073 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400001074 PPE family; Region: PPE; pfam00823 1306400001075 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1306400001076 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306400001077 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1306400001078 active site residue [active] 1306400001079 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1306400001080 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1306400001081 homodimer interface [polypeptide binding]; other site 1306400001082 substrate-cofactor binding pocket; other site 1306400001083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400001084 catalytic residue [active] 1306400001085 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1306400001086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400001087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400001088 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400001089 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400001090 active site 1306400001091 PLD-like domain; Region: PLDc_2; pfam13091 1306400001092 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400001093 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400001094 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400001095 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400001096 active site 1306400001097 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1306400001098 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306400001099 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306400001100 acyl-CoA synthetase; Validated; Region: PRK05850 1306400001101 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400001102 acyl-activating enzyme (AAE) consensus motif; other site 1306400001103 active site 1306400001104 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306400001105 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1306400001106 active site 1306400001107 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306400001108 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400001109 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400001110 Thioesterase; Region: PKS_TE; smart00824 1306400001111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306400001112 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1306400001113 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1306400001114 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400001115 phosphate acetyltransferase; Reviewed; Region: PRK05632 1306400001116 DRTGG domain; Region: DRTGG; pfam07085 1306400001117 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1306400001118 propionate/acetate kinase; Provisional; Region: PRK12379 1306400001119 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1306400001120 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400001121 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400001122 active site 1306400001123 ATP binding site [chemical binding]; other site 1306400001124 substrate binding site [chemical binding]; other site 1306400001125 activation loop (A-loop); other site 1306400001126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1306400001127 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1306400001128 substrate binding pocket [chemical binding]; other site 1306400001129 membrane-bound complex binding site; other site 1306400001130 hinge residues; other site 1306400001131 NUDIX domain; Region: NUDIX; pfam00293 1306400001132 nudix motif; other site 1306400001133 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1306400001134 thiamine phosphate binding site [chemical binding]; other site 1306400001135 active site 1306400001136 pyrophosphate binding site [ion binding]; other site 1306400001137 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1306400001138 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1306400001139 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1306400001140 thiS-thiF/thiG interaction site; other site 1306400001141 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1306400001142 ThiS interaction site; other site 1306400001143 putative active site [active] 1306400001144 tetramer interface [polypeptide binding]; other site 1306400001145 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1306400001146 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1306400001147 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1306400001148 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1306400001149 PA/protease or protease-like domain interface [polypeptide binding]; other site 1306400001150 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1306400001151 active site 1306400001152 metal binding site [ion binding]; metal-binding site 1306400001153 Predicted metalloprotease [General function prediction only]; Region: COG2321 1306400001154 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1306400001155 Zn binding site [ion binding]; other site 1306400001156 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1306400001157 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1306400001158 dimer interface [polypeptide binding]; other site 1306400001159 substrate binding site [chemical binding]; other site 1306400001160 ATP binding site [chemical binding]; other site 1306400001161 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1306400001162 ThiC-associated domain; Region: ThiC-associated; pfam13667 1306400001163 ThiC family; Region: ThiC; pfam01964 1306400001164 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400001165 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1306400001166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400001167 motif II; other site 1306400001168 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1306400001169 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1306400001170 putative catalytic site [active] 1306400001171 putative phosphate binding site [ion binding]; other site 1306400001172 active site 1306400001173 metal binding site A [ion binding]; metal-binding site 1306400001174 DNA binding site [nucleotide binding] 1306400001175 putative AP binding site [nucleotide binding]; other site 1306400001176 putative metal binding site B [ion binding]; other site 1306400001177 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1306400001178 active site 1306400001179 catalytic residues [active] 1306400001180 metal binding site [ion binding]; metal-binding site 1306400001181 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1306400001182 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306400001183 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1306400001184 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1306400001185 E-class dimer interface [polypeptide binding]; other site 1306400001186 P-class dimer interface [polypeptide binding]; other site 1306400001187 active site 1306400001188 Cu2+ binding site [ion binding]; other site 1306400001189 Zn2+ binding site [ion binding]; other site 1306400001190 carboxylate-amine ligase; Provisional; Region: PRK13517 1306400001191 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1306400001192 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1306400001193 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1306400001194 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1306400001195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400001196 Walker A motif; other site 1306400001197 ATP binding site [chemical binding]; other site 1306400001198 Walker B motif; other site 1306400001199 arginine finger; other site 1306400001200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400001201 Walker A motif; other site 1306400001202 ATP binding site [chemical binding]; other site 1306400001203 Walker B motif; other site 1306400001204 arginine finger; other site 1306400001205 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1306400001206 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1306400001207 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1306400001208 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1306400001209 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1306400001210 dimer interface [polypeptide binding]; other site 1306400001211 putative functional site; other site 1306400001212 putative MPT binding site; other site 1306400001213 short chain dehydrogenase; Provisional; Region: PRK06197 1306400001214 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1306400001215 putative NAD(P) binding site [chemical binding]; other site 1306400001216 active site 1306400001217 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1306400001218 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1306400001219 ring oligomerisation interface [polypeptide binding]; other site 1306400001220 ATP/Mg binding site [chemical binding]; other site 1306400001221 stacking interactions; other site 1306400001222 hinge regions; other site 1306400001223 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400001224 PPE family; Region: PPE; pfam00823 1306400001225 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1306400001226 DinB superfamily; Region: DinB_2; pfam12867 1306400001227 putative anti-sigmaE protein; Provisional; Region: PRK13920 1306400001228 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1306400001229 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1306400001230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400001231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400001232 DNA binding residues [nucleotide binding] 1306400001233 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1306400001234 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400001235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001236 S-adenosylmethionine binding site [chemical binding]; other site 1306400001237 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1306400001238 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1306400001239 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1306400001240 dimer interface [polypeptide binding]; other site 1306400001241 Transport protein; Region: actII; TIGR00833 1306400001242 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306400001243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400001244 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400001245 PPE family; Region: PPE; pfam00823 1306400001246 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400001247 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1306400001248 enoyl-CoA hydratase; Provisional; Region: PRK12478 1306400001249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400001250 substrate binding site [chemical binding]; other site 1306400001251 oxyanion hole (OAH) forming residues; other site 1306400001252 trimer interface [polypeptide binding]; other site 1306400001253 PemK-like protein; Region: PemK; pfam02452 1306400001254 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1306400001255 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306400001256 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1306400001257 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1306400001258 NAD(P) binding site [chemical binding]; other site 1306400001259 catalytic residues [active] 1306400001260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1306400001261 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1306400001262 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1306400001263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400001264 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306400001265 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1306400001266 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1306400001267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306400001268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400001269 non-specific DNA binding site [nucleotide binding]; other site 1306400001270 salt bridge; other site 1306400001271 sequence-specific DNA binding site [nucleotide binding]; other site 1306400001272 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1306400001273 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1306400001274 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1306400001275 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1306400001276 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1306400001277 active site 1306400001278 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306400001279 active site 2 [active] 1306400001280 isocitrate lyase; Provisional; Region: PRK15063 1306400001281 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1306400001282 oligomerization interface [polypeptide binding]; other site 1306400001283 active site 1306400001284 metal binding site [ion binding]; metal-binding site 1306400001285 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1306400001286 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1306400001287 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1306400001288 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400001289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001290 S-adenosylmethionine binding site [chemical binding]; other site 1306400001291 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400001292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306400001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001294 S-adenosylmethionine binding site [chemical binding]; other site 1306400001295 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1306400001296 UbiA prenyltransferase family; Region: UbiA; pfam01040 1306400001297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400001298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400001299 Predicted membrane protein [Function unknown]; Region: COG2733 1306400001300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306400001301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400001302 non-specific DNA binding site [nucleotide binding]; other site 1306400001303 salt bridge; other site 1306400001304 sequence-specific DNA binding site [nucleotide binding]; other site 1306400001305 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1306400001306 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1306400001307 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1306400001308 intersubunit interface [polypeptide binding]; other site 1306400001309 active site 1306400001310 catalytic residue [active] 1306400001311 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1306400001312 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1306400001313 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1306400001314 putative active site [active] 1306400001315 catalytic triad [active] 1306400001316 putative dimer interface [polypeptide binding]; other site 1306400001317 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1306400001318 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1306400001319 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400001320 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1306400001321 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306400001322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306400001323 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1306400001324 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306400001325 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1306400001326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400001327 NAD(P) binding site [chemical binding]; other site 1306400001328 active site 1306400001329 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1306400001330 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306400001331 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1306400001332 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1306400001333 putative ADP-binding pocket [chemical binding]; other site 1306400001334 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1306400001335 L-lysine exporter; Region: 2a75; TIGR00948 1306400001336 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400001337 catalytic core [active] 1306400001338 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1306400001339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306400001340 dimer interface [polypeptide binding]; other site 1306400001341 phosphorylation site [posttranslational modification] 1306400001342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400001343 ATP binding site [chemical binding]; other site 1306400001344 Mg2+ binding site [ion binding]; other site 1306400001345 G-X-G motif; other site 1306400001346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400001347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400001348 active site 1306400001349 phosphorylation site [posttranslational modification] 1306400001350 intermolecular recognition site; other site 1306400001351 dimerization interface [polypeptide binding]; other site 1306400001352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400001353 DNA binding site [nucleotide binding] 1306400001354 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1306400001355 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1306400001356 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306400001357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306400001358 DNA-binding site [nucleotide binding]; DNA binding site 1306400001359 FCD domain; Region: FCD; pfam07729 1306400001360 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1306400001361 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1306400001362 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1306400001363 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1306400001364 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1306400001365 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1306400001366 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1306400001367 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1306400001368 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1306400001369 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1306400001370 DNA binding domain, excisionase family; Region: excise; TIGR01764 1306400001371 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306400001372 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1306400001373 putative NAD(P) binding site [chemical binding]; other site 1306400001374 active site 1306400001375 putative substrate binding site [chemical binding]; other site 1306400001376 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400001377 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1306400001378 putative acyl-acceptor binding pocket; other site 1306400001379 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400001380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306400001381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001382 S-adenosylmethionine binding site [chemical binding]; other site 1306400001383 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1306400001384 active site 1306400001385 catalytic site [active] 1306400001386 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1306400001387 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1306400001388 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306400001389 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306400001390 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1306400001391 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1306400001392 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1306400001393 tRNA; other site 1306400001394 putative tRNA binding site [nucleotide binding]; other site 1306400001395 putative NADP binding site [chemical binding]; other site 1306400001396 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1306400001397 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1306400001398 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1306400001399 domain interfaces; other site 1306400001400 active site 1306400001401 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1306400001402 active site 1306400001403 homodimer interface [polypeptide binding]; other site 1306400001404 SAM binding site [chemical binding]; other site 1306400001405 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1306400001406 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1306400001407 active site 1306400001408 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1306400001409 dimer interface [polypeptide binding]; other site 1306400001410 active site 1306400001411 Schiff base residues; other site 1306400001412 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400001413 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400001414 active site 1306400001415 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306400001416 anti sigma factor interaction site; other site 1306400001417 regulatory phosphorylation site [posttranslational modification]; other site 1306400001418 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1306400001419 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1306400001420 active site 1306400001421 catalytic triad [active] 1306400001422 oxyanion hole [active] 1306400001423 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1306400001424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001425 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306400001426 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1306400001427 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306400001428 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1306400001429 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306400001430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400001431 catalytic residue [active] 1306400001432 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400001433 catalytic core [active] 1306400001434 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1306400001435 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306400001436 catalytic residues [active] 1306400001437 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1306400001438 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1306400001439 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1306400001440 ResB-like family; Region: ResB; pfam05140 1306400001441 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1306400001442 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306400001443 AAA domain; Region: AAA_31; pfam13614 1306400001444 P-loop; other site 1306400001445 Magnesium ion binding site [ion binding]; other site 1306400001446 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1306400001447 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1306400001448 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1306400001449 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1306400001450 dimer interface [polypeptide binding]; other site 1306400001451 active site 1306400001452 CoA binding pocket [chemical binding]; other site 1306400001453 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1306400001454 UbiA prenyltransferase family; Region: UbiA; pfam01040 1306400001455 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1306400001456 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306400001457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400001458 NAD(P) binding site [chemical binding]; other site 1306400001459 active site 1306400001460 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306400001461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1306400001462 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1306400001463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400001464 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400001465 acyl-activating enzyme (AAE) consensus motif; other site 1306400001466 acyl-activating enzyme (AAE) consensus motif; other site 1306400001467 AMP binding site [chemical binding]; other site 1306400001468 active site 1306400001469 CoA binding site [chemical binding]; other site 1306400001470 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1306400001471 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1306400001472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400001473 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1306400001474 active site 1306400001475 short chain dehydrogenase; Provisional; Region: PRK05866 1306400001476 classical (c) SDRs; Region: SDR_c; cd05233 1306400001477 NAD(P) binding site [chemical binding]; other site 1306400001478 active site 1306400001479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400001480 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1306400001481 substrate binding site [chemical binding]; other site 1306400001482 oxyanion hole (OAH) forming residues; other site 1306400001483 trimer interface [polypeptide binding]; other site 1306400001484 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1306400001485 putative active site [active] 1306400001486 homotetrameric interface [polypeptide binding]; other site 1306400001487 metal binding site [ion binding]; metal-binding site 1306400001488 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1306400001489 acyl-CoA synthetase; Validated; Region: PRK06188 1306400001490 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1306400001491 putative active site [active] 1306400001492 putative CoA binding site [chemical binding]; other site 1306400001493 putative AMP binding site [chemical binding]; other site 1306400001494 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1306400001495 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1306400001496 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1306400001497 active site 1306400001498 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1306400001499 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1306400001500 active site 1306400001501 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400001502 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1306400001503 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306400001504 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1306400001505 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1306400001506 TPP-binding site; other site 1306400001507 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1306400001508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306400001509 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1306400001510 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1306400001511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001512 S-adenosylmethionine binding site [chemical binding]; other site 1306400001513 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400001514 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400001515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001516 S-adenosylmethionine binding site [chemical binding]; other site 1306400001517 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1306400001518 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306400001519 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306400001520 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306400001521 substrate binding pocket [chemical binding]; other site 1306400001522 chain length determination region; other site 1306400001523 substrate-Mg2+ binding site; other site 1306400001524 catalytic residues [active] 1306400001525 aspartate-rich region 1; other site 1306400001526 active site lid residues [active] 1306400001527 aspartate-rich region 2; other site 1306400001528 heat shock protein HtpX; Provisional; Region: PRK03072 1306400001529 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1306400001530 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1306400001531 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1306400001532 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400001533 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306400001534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1306400001535 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1306400001536 O-methyltransferase; Region: Methyltransf_2; pfam00891 1306400001537 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400001538 Cytochrome P450; Region: p450; cl12078 1306400001539 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1306400001540 ATP cone domain; Region: ATP-cone; pfam03477 1306400001541 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1306400001542 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1306400001543 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1306400001544 active site 1306400001545 dimer interface [polypeptide binding]; other site 1306400001546 effector binding site; other site 1306400001547 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1306400001548 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400001549 active site 1306400001550 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306400001551 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1306400001552 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1306400001553 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1306400001554 active site 1306400001555 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1306400001556 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1306400001557 putative active site [active] 1306400001558 putative metal binding site [ion binding]; other site 1306400001559 hypothetical protein; Provisional; Region: PRK07588 1306400001560 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306400001561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400001562 dimerization interface [polypeptide binding]; other site 1306400001563 putative DNA binding site [nucleotide binding]; other site 1306400001564 putative Zn2+ binding site [ion binding]; other site 1306400001565 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1306400001566 putative hydrophobic ligand binding site [chemical binding]; other site 1306400001567 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306400001568 TIGR03086 family protein; Region: TIGR03086 1306400001569 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1306400001570 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400001571 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1306400001572 PE family; Region: PE; pfam00934 1306400001573 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1306400001574 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1306400001575 Protein of unknown function DUF82; Region: DUF82; pfam01927 1306400001576 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400001577 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306400001578 putative active site [active] 1306400001579 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1306400001580 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1306400001581 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1306400001582 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1306400001583 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306400001584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306400001585 DNA-binding site [nucleotide binding]; DNA binding site 1306400001586 FCD domain; Region: FCD; pfam07729 1306400001587 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306400001588 Permease; Region: Permease; pfam02405 1306400001589 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306400001590 Permease; Region: Permease; pfam02405 1306400001591 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400001592 mce related protein; Region: MCE; pfam02470 1306400001593 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306400001594 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1306400001595 mce related protein; Region: MCE; pfam02470 1306400001596 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306400001597 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400001598 mce related protein; Region: MCE; pfam02470 1306400001599 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400001600 mce related protein; Region: MCE; pfam02470 1306400001601 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306400001602 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400001603 mce related protein; Region: MCE; pfam02470 1306400001604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400001605 mce related protein; Region: MCE; pfam02470 1306400001606 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1306400001607 oligomeric interface; other site 1306400001608 putative active site [active] 1306400001609 homodimer interface [polypeptide binding]; other site 1306400001610 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400001611 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1306400001612 AAA domain; Region: AAA_14; pfam13173 1306400001613 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1306400001614 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1306400001615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306400001616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400001617 ATP binding site [chemical binding]; other site 1306400001618 Mg2+ binding site [ion binding]; other site 1306400001619 G-X-G motif; other site 1306400001620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400001621 dimerization interface [polypeptide binding]; other site 1306400001622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400001623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400001624 active site 1306400001625 phosphorylation site [posttranslational modification] 1306400001626 intermolecular recognition site; other site 1306400001627 dimerization interface [polypeptide binding]; other site 1306400001628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400001629 DNA binding site [nucleotide binding] 1306400001630 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1306400001631 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1306400001632 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306400001633 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1306400001634 catalytic residues [active] 1306400001635 catalytic nucleophile [active] 1306400001636 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306400001637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306400001638 Probable transposase; Region: OrfB_IS605; pfam01385 1306400001639 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1306400001640 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1306400001641 putative active site [active] 1306400001642 SEC-C motif; Region: SEC-C; pfam02810 1306400001643 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1306400001644 putative active site [active] 1306400001645 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1306400001646 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1306400001647 nucleotide binding site/active site [active] 1306400001648 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1306400001649 galactokinase; Provisional; Region: PRK00555 1306400001650 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1306400001651 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400001652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1306400001653 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1306400001654 putative active site [active] 1306400001655 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1306400001656 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1306400001657 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400001658 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1306400001659 oligomeric interface; other site 1306400001660 putative active site [active] 1306400001661 homodimer interface [polypeptide binding]; other site 1306400001662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1306400001663 FIST N domain; Region: FIST; pfam08495 1306400001664 FIST C domain; Region: FIST_C; pfam10442 1306400001665 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1306400001666 AAA domain; Region: AAA_30; pfam13604 1306400001667 Family description; Region: UvrD_C_2; pfam13538 1306400001668 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1306400001669 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1306400001670 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1306400001671 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1306400001672 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306400001673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400001674 substrate binding site [chemical binding]; other site 1306400001675 oxyanion hole (OAH) forming residues; other site 1306400001676 trimer interface [polypeptide binding]; other site 1306400001677 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1306400001678 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306400001679 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1306400001680 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1306400001681 active site 1306400001682 catalytic site [active] 1306400001683 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1306400001684 active site 1306400001685 catalytic site [active] 1306400001686 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1306400001687 active site 1306400001688 catalytic site [active] 1306400001689 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1306400001690 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1306400001691 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1306400001692 putative homodimer interface [polypeptide binding]; other site 1306400001693 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1306400001694 heterodimer interface [polypeptide binding]; other site 1306400001695 homodimer interface [polypeptide binding]; other site 1306400001696 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1306400001697 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1306400001698 23S rRNA interface [nucleotide binding]; other site 1306400001699 L7/L12 interface [polypeptide binding]; other site 1306400001700 putative thiostrepton binding site; other site 1306400001701 L25 interface [polypeptide binding]; other site 1306400001702 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1306400001703 mRNA/rRNA interface [nucleotide binding]; other site 1306400001704 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400001705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001706 S-adenosylmethionine binding site [chemical binding]; other site 1306400001707 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306400001709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001710 S-adenosylmethionine binding site [chemical binding]; other site 1306400001711 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400001712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306400001713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001714 S-adenosylmethionine binding site [chemical binding]; other site 1306400001715 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400001716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306400001717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400001718 S-adenosylmethionine binding site [chemical binding]; other site 1306400001719 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400001720 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306400001721 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1306400001722 ABC1 family; Region: ABC1; cl17513 1306400001723 potential frameshift: common BLAST hit: gi|471336493|ref|YP_007609206.1| alpha-mannosidase 1306400001724 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1306400001725 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306400001726 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1306400001727 23S rRNA interface [nucleotide binding]; other site 1306400001728 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1306400001729 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1306400001730 core dimer interface [polypeptide binding]; other site 1306400001731 peripheral dimer interface [polypeptide binding]; other site 1306400001732 L10 interface [polypeptide binding]; other site 1306400001733 L11 interface [polypeptide binding]; other site 1306400001734 putative EF-Tu interaction site [polypeptide binding]; other site 1306400001735 putative EF-G interaction site [polypeptide binding]; other site 1306400001736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400001737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400001738 WHG domain; Region: WHG; pfam13305 1306400001739 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1306400001740 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1306400001741 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1306400001742 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1306400001743 Walker A/P-loop; other site 1306400001744 ATP binding site [chemical binding]; other site 1306400001745 Q-loop/lid; other site 1306400001746 ABC transporter signature motif; other site 1306400001747 Walker B; other site 1306400001748 D-loop; other site 1306400001749 H-loop/switch region; other site 1306400001750 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1306400001751 putative active site [active] 1306400001752 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306400001753 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1306400001754 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306400001755 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1306400001756 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306400001757 Sulfatase; Region: Sulfatase; pfam00884 1306400001758 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1306400001759 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400001760 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1306400001761 putative active site [active] 1306400001762 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1306400001763 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1306400001764 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1306400001765 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1306400001766 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1306400001767 RPB10 interaction site [polypeptide binding]; other site 1306400001768 RPB1 interaction site [polypeptide binding]; other site 1306400001769 RPB11 interaction site [polypeptide binding]; other site 1306400001770 RPB3 interaction site [polypeptide binding]; other site 1306400001771 RPB12 interaction site [polypeptide binding]; other site 1306400001772 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1306400001773 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1306400001774 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1306400001775 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1306400001776 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1306400001777 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1306400001778 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1306400001779 G-loop; other site 1306400001780 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1306400001781 DNA binding site [nucleotide binding] 1306400001782 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1306400001783 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1306400001784 endonuclease IV; Provisional; Region: PRK01060 1306400001785 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1306400001786 AP (apurinic/apyrimidinic) site pocket; other site 1306400001787 DNA interaction; other site 1306400001788 Metal-binding active site; metal-binding site 1306400001789 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1306400001790 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1306400001791 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1306400001792 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400001793 active site 1306400001794 enoyl-CoA hydratase; Provisional; Region: PRK12478 1306400001795 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400001796 substrate binding site [chemical binding]; other site 1306400001797 oxyanion hole (OAH) forming residues; other site 1306400001798 trimer interface [polypeptide binding]; other site 1306400001799 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1306400001800 PaaX-like protein; Region: PaaX; pfam07848 1306400001801 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1306400001802 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306400001803 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400001804 substrate binding site [chemical binding]; other site 1306400001805 oxyanion hole (OAH) forming residues; other site 1306400001806 trimer interface [polypeptide binding]; other site 1306400001807 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306400001808 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306400001809 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1306400001810 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1306400001811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400001812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400001813 WHG domain; Region: WHG; pfam13305 1306400001814 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1306400001815 S17 interaction site [polypeptide binding]; other site 1306400001816 S8 interaction site; other site 1306400001817 16S rRNA interaction site [nucleotide binding]; other site 1306400001818 streptomycin interaction site [chemical binding]; other site 1306400001819 23S rRNA interaction site [nucleotide binding]; other site 1306400001820 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1306400001821 30S ribosomal protein S7; Validated; Region: PRK05302 1306400001822 elongation factor G; Reviewed; Region: PRK00007 1306400001823 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1306400001824 G1 box; other site 1306400001825 putative GEF interaction site [polypeptide binding]; other site 1306400001826 GTP/Mg2+ binding site [chemical binding]; other site 1306400001827 Switch I region; other site 1306400001828 G2 box; other site 1306400001829 G3 box; other site 1306400001830 Switch II region; other site 1306400001831 G4 box; other site 1306400001832 G5 box; other site 1306400001833 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1306400001834 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1306400001835 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1306400001836 elongation factor Tu; Reviewed; Region: PRK00049 1306400001837 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1306400001838 G1 box; other site 1306400001839 GEF interaction site [polypeptide binding]; other site 1306400001840 GTP/Mg2+ binding site [chemical binding]; other site 1306400001841 Switch I region; other site 1306400001842 G2 box; other site 1306400001843 G3 box; other site 1306400001844 Switch II region; other site 1306400001845 G4 box; other site 1306400001846 G5 box; other site 1306400001847 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1306400001848 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1306400001849 Antibiotic Binding Site [chemical binding]; other site 1306400001850 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1306400001851 classical (c) SDRs; Region: SDR_c; cd05233 1306400001852 NAD(P) binding site [chemical binding]; other site 1306400001853 active site 1306400001854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1306400001855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400001856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1306400001857 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1306400001858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400001859 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1306400001860 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1306400001861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400001862 FeS/SAM binding site; other site 1306400001863 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1306400001864 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1306400001865 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306400001866 phosphate binding site [ion binding]; other site 1306400001867 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1306400001868 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1306400001869 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1306400001870 Probable Catalytic site; other site 1306400001871 metal-binding site 1306400001872 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1306400001873 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1306400001874 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1306400001875 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1306400001876 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1306400001877 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1306400001878 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1306400001879 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1306400001880 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1306400001881 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1306400001882 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1306400001883 putative translocon binding site; other site 1306400001884 protein-rRNA interface [nucleotide binding]; other site 1306400001885 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1306400001886 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1306400001887 G-X-X-G motif; other site 1306400001888 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1306400001889 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1306400001890 23S rRNA interface [nucleotide binding]; other site 1306400001891 5S rRNA interface [nucleotide binding]; other site 1306400001892 putative antibiotic binding site [chemical binding]; other site 1306400001893 L25 interface [polypeptide binding]; other site 1306400001894 L27 interface [polypeptide binding]; other site 1306400001895 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1306400001896 putative translocon interaction site; other site 1306400001897 23S rRNA interface [nucleotide binding]; other site 1306400001898 signal recognition particle (SRP54) interaction site; other site 1306400001899 L23 interface [polypeptide binding]; other site 1306400001900 trigger factor interaction site; other site 1306400001901 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1306400001902 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306400001903 Sulfatase; Region: Sulfatase; pfam00884 1306400001904 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1306400001905 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1306400001906 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1306400001907 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1306400001908 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1306400001909 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1306400001910 RNA binding site [nucleotide binding]; other site 1306400001911 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1306400001912 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1306400001913 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1306400001914 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1306400001915 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1306400001916 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1306400001917 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1306400001918 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1306400001919 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1306400001920 5S rRNA interface [nucleotide binding]; other site 1306400001921 23S rRNA interface [nucleotide binding]; other site 1306400001922 L5 interface [polypeptide binding]; other site 1306400001923 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1306400001924 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1306400001925 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1306400001926 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1306400001927 23S rRNA binding site [nucleotide binding]; other site 1306400001928 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1306400001929 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1306400001930 tandem repeat interface [polypeptide binding]; other site 1306400001931 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1306400001932 oligomer interface [polypeptide binding]; other site 1306400001933 active site residues [active] 1306400001934 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1306400001935 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1306400001936 tandem repeat interface [polypeptide binding]; other site 1306400001937 oligomer interface [polypeptide binding]; other site 1306400001938 active site residues [active] 1306400001939 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400001940 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400001941 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400001942 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400001943 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1306400001944 intersubunit interface [polypeptide binding]; other site 1306400001945 active site 1306400001946 Zn2+ binding site [ion binding]; other site 1306400001947 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1306400001948 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1306400001949 NAD binding site [chemical binding]; other site 1306400001950 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1306400001951 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306400001952 nucleotide binding site [chemical binding]; other site 1306400001953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1306400001954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400001955 Coenzyme A binding pocket [chemical binding]; other site 1306400001956 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400001957 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400001958 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1306400001959 SecY translocase; Region: SecY; pfam00344 1306400001960 adenylate kinase; Reviewed; Region: adk; PRK00279 1306400001961 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1306400001962 AMP-binding site [chemical binding]; other site 1306400001963 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1306400001964 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1306400001965 active site 1306400001966 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1306400001967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400001968 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400001969 DNA binding residues [nucleotide binding] 1306400001970 Putative zinc-finger; Region: zf-HC2; pfam13490 1306400001971 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306400001972 MarR family; Region: MarR; pfam01047 1306400001973 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306400001974 TIGR03086 family protein; Region: TIGR03086 1306400001975 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1306400001976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306400001977 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306400001978 Helix-turn-helix domain; Region: HTH_17; pfam12728 1306400001979 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1306400001980 PE family; Region: PE; pfam00934 1306400001981 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400001982 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400001983 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1306400001984 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1306400001985 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400001986 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400001987 active site 1306400001988 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1306400001989 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1306400001990 tetrameric interface [polypeptide binding]; other site 1306400001991 NAD binding site [chemical binding]; other site 1306400001992 catalytic residues [active] 1306400001993 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400001994 catalytic core [active] 1306400001995 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400001996 PPE family; Region: PPE; pfam00823 1306400001997 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400001998 Helix-turn-helix domain; Region: HTH_28; pfam13518 1306400001999 Winged helix-turn helix; Region: HTH_29; pfam13551 1306400002000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400002001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400002002 active site 1306400002003 phosphorylation site [posttranslational modification] 1306400002004 intermolecular recognition site; other site 1306400002005 dimerization interface [polypeptide binding]; other site 1306400002006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400002007 DNA binding site [nucleotide binding] 1306400002008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306400002009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400002010 dimerization interface [polypeptide binding]; other site 1306400002011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306400002012 dimer interface [polypeptide binding]; other site 1306400002013 phosphorylation site [posttranslational modification] 1306400002014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400002015 ATP binding site [chemical binding]; other site 1306400002016 Mg2+ binding site [ion binding]; other site 1306400002017 G-X-G motif; other site 1306400002018 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1306400002019 nucleotide binding site/active site [active] 1306400002020 HIT family signature motif; other site 1306400002021 catalytic residue [active] 1306400002022 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1306400002023 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1306400002024 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1306400002025 NAD binding site [chemical binding]; other site 1306400002026 catalytic Zn binding site [ion binding]; other site 1306400002027 substrate binding site [chemical binding]; other site 1306400002028 structural Zn binding site [ion binding]; other site 1306400002029 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1306400002030 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1306400002031 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1306400002032 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400002033 Cytochrome P450; Region: p450; cl12078 1306400002034 short chain dehydrogenase; Provisional; Region: PRK07775 1306400002035 classical (c) SDRs; Region: SDR_c; cd05233 1306400002036 NAD(P) binding site [chemical binding]; other site 1306400002037 active site 1306400002038 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400002039 Cytochrome P450; Region: p450; cl12078 1306400002040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400002041 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1306400002042 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1306400002043 NAD binding site [chemical binding]; other site 1306400002044 catalytic residues [active] 1306400002045 short chain dehydrogenase; Provisional; Region: PRK07774 1306400002046 classical (c) SDRs; Region: SDR_c; cd05233 1306400002047 NAD(P) binding site [chemical binding]; other site 1306400002048 active site 1306400002049 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1306400002050 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1306400002051 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1306400002052 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1306400002053 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1306400002054 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1306400002055 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1306400002056 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1306400002057 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1306400002058 Predicted esterase [General function prediction only]; Region: COG0627 1306400002059 S-formylglutathione hydrolase; Region: PLN02442 1306400002060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1306400002061 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1306400002062 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1306400002063 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1306400002064 tetramer interface [polypeptide binding]; other site 1306400002065 active site 1306400002066 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400002067 Cytochrome P450; Region: p450; cl12078 1306400002068 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1306400002069 ATP binding site [chemical binding]; other site 1306400002070 active site 1306400002071 substrate binding site [chemical binding]; other site 1306400002072 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1306400002073 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306400002074 WHG domain; Region: WHG; pfam13305 1306400002075 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306400002076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400002077 putative substrate translocation pore; other site 1306400002078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400002079 Predicted deacetylase [General function prediction only]; Region: COG3233 1306400002080 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1306400002081 putative active site [active] 1306400002082 putative Zn binding site [ion binding]; other site 1306400002083 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1306400002084 FAD binding domain; Region: FAD_binding_2; pfam00890 1306400002085 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1306400002086 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1306400002087 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1306400002088 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1306400002089 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1306400002090 putative active site [active] 1306400002091 catalytic triad [active] 1306400002092 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306400002093 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1306400002094 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400002095 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1306400002096 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400002097 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1306400002098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306400002099 DNA-binding site [nucleotide binding]; DNA binding site 1306400002100 UTRA domain; Region: UTRA; pfam07702 1306400002101 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1306400002102 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1306400002103 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1306400002104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400002105 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306400002106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400002107 Transposase; Region: HTH_Tnp_1; cl17663 1306400002108 putative transposase OrfB; Reviewed; Region: PHA02517 1306400002109 HTH-like domain; Region: HTH_21; pfam13276 1306400002110 Integrase core domain; Region: rve; pfam00665 1306400002111 Integrase core domain; Region: rve_3; pfam13683 1306400002112 potential frameshift: common BLAST hit: gi|15840209|ref|NP_335246.1| IS1547 transposase 1306400002113 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1306400002114 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1306400002115 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1306400002116 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1306400002117 active site 1306400002118 metal binding site [ion binding]; metal-binding site 1306400002119 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1306400002120 active site 1306400002121 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400002122 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1306400002123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1306400002124 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1306400002125 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1306400002126 dimerization interface [polypeptide binding]; other site 1306400002127 ATP binding site [chemical binding]; other site 1306400002128 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1306400002129 dimerization interface [polypeptide binding]; other site 1306400002130 ATP binding site [chemical binding]; other site 1306400002131 CAAX protease self-immunity; Region: Abi; pfam02517 1306400002132 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1306400002133 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1306400002134 active site 1306400002135 metal binding site [ion binding]; metal-binding site 1306400002136 hexamer interface [polypeptide binding]; other site 1306400002137 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1306400002138 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1306400002139 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1306400002140 active site 1306400002141 tetramer interface [polypeptide binding]; other site 1306400002142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400002143 active site 1306400002144 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1306400002145 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1306400002146 dimerization interface [polypeptide binding]; other site 1306400002147 putative ATP binding site [chemical binding]; other site 1306400002148 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1306400002149 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1306400002150 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1306400002151 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1306400002152 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1306400002153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400002154 catalytic residue [active] 1306400002155 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1306400002156 heme-binding site [chemical binding]; other site 1306400002157 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1306400002158 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1306400002159 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1306400002160 active site residue [active] 1306400002161 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1306400002162 active site residue [active] 1306400002163 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1306400002164 catalytic residues [active] 1306400002165 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1306400002166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400002167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400002168 DNA binding site [nucleotide binding] 1306400002169 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1306400002170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400002171 Coenzyme A binding pocket [chemical binding]; other site 1306400002172 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1306400002173 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1306400002174 Walker A/P-loop; other site 1306400002175 ATP binding site [chemical binding]; other site 1306400002176 Q-loop/lid; other site 1306400002177 ABC transporter signature motif; other site 1306400002178 Walker B; other site 1306400002179 D-loop; other site 1306400002180 H-loop/switch region; other site 1306400002181 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1306400002182 PhoU domain; Region: PhoU; pfam01895 1306400002183 PhoU domain; Region: PhoU; pfam01895 1306400002184 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1306400002185 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306400002186 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1306400002187 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1306400002188 FMN binding site [chemical binding]; other site 1306400002189 active site 1306400002190 catalytic residues [active] 1306400002191 substrate binding site [chemical binding]; other site 1306400002192 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1306400002193 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1306400002194 homodimer interface [polypeptide binding]; other site 1306400002195 putative substrate binding pocket [chemical binding]; other site 1306400002196 diiron center [ion binding]; other site 1306400002197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400002198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1306400002199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400002200 dimerization interface [polypeptide binding]; other site 1306400002201 putative DNA binding site [nucleotide binding]; other site 1306400002202 putative Zn2+ binding site [ion binding]; other site 1306400002203 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1306400002204 dimer interface [polypeptide binding]; other site 1306400002205 catalytic motif [active] 1306400002206 nucleoside/Zn binding site; other site 1306400002207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306400002208 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400002209 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400002210 TIGR04255 family protein; Region: sporadTIGR04255 1306400002211 PE family; Region: PE; pfam00934 1306400002212 PE family; Region: PE; pfam00934 1306400002213 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306400002214 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1306400002215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1306400002216 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1306400002217 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 1306400002218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400002219 S-adenosylmethionine binding site [chemical binding]; other site 1306400002220 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1306400002221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400002222 putative substrate translocation pore; other site 1306400002223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306400002224 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1306400002225 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1306400002226 tetramer interface [polypeptide binding]; other site 1306400002227 TPP-binding site [chemical binding]; other site 1306400002228 heterodimer interface [polypeptide binding]; other site 1306400002229 phosphorylation loop region [posttranslational modification] 1306400002230 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306400002231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400002232 active site 1306400002233 phosphorylation site [posttranslational modification] 1306400002234 intermolecular recognition site; other site 1306400002235 dimerization interface [polypeptide binding]; other site 1306400002236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306400002237 DNA binding residues [nucleotide binding] 1306400002238 dimerization interface [polypeptide binding]; other site 1306400002239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1306400002240 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1306400002241 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1306400002242 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1306400002243 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1306400002244 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1306400002245 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1306400002246 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1306400002247 dimer interface [polypeptide binding]; other site 1306400002248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400002249 catalytic residue [active] 1306400002250 potential frameshift: common BLAST hit: gi|471336712|ref|YP_007609425.1| integral membrane transport protein 1306400002251 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1306400002252 short chain dehydrogenase; Provisional; Region: PRK05876 1306400002253 classical (c) SDRs; Region: SDR_c; cd05233 1306400002254 NAD(P) binding site [chemical binding]; other site 1306400002255 active site 1306400002256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400002257 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1306400002258 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1306400002259 dimer interface [polypeptide binding]; other site 1306400002260 PYR/PP interface [polypeptide binding]; other site 1306400002261 TPP binding site [chemical binding]; other site 1306400002262 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306400002263 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1306400002264 TPP-binding site [chemical binding]; other site 1306400002265 dimer interface [polypeptide binding]; other site 1306400002266 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306400002267 putative hydrophobic ligand binding site [chemical binding]; other site 1306400002268 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306400002269 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306400002270 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306400002271 putative hydrophobic ligand binding site [chemical binding]; other site 1306400002272 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306400002273 putative hydrophobic ligand binding site [chemical binding]; other site 1306400002274 aminotransferase; Validated; Region: PRK07777 1306400002275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400002276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400002277 homodimer interface [polypeptide binding]; other site 1306400002278 catalytic residue [active] 1306400002279 potential frameshift: common BLAST hit: gi|449062892|ref|YP_007429975.1| acetyl-CoA acetyltransferase 1306400002280 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1306400002281 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400002282 substrate binding site [chemical binding]; other site 1306400002283 oxyanion hole (OAH) forming residues; other site 1306400002284 trimer interface [polypeptide binding]; other site 1306400002285 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1306400002286 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1306400002287 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1306400002288 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1306400002289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306400002290 ATP binding site [chemical binding]; other site 1306400002291 putative Mg++ binding site [ion binding]; other site 1306400002292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400002293 nucleotide binding region [chemical binding]; other site 1306400002294 ATP-binding site [chemical binding]; other site 1306400002295 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1306400002296 WYL domain; Region: WYL; pfam13280 1306400002297 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1306400002298 trimer interface [polypeptide binding]; other site 1306400002299 dimer interface [polypeptide binding]; other site 1306400002300 putative active site [active] 1306400002301 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1306400002302 MPT binding site; other site 1306400002303 trimer interface [polypeptide binding]; other site 1306400002304 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1306400002305 MoaE homodimer interface [polypeptide binding]; other site 1306400002306 MoaD interaction [polypeptide binding]; other site 1306400002307 active site residues [active] 1306400002308 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306400002309 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1306400002310 MoaE interaction surface [polypeptide binding]; other site 1306400002311 MoeB interaction surface [polypeptide binding]; other site 1306400002312 thiocarboxylated glycine; other site 1306400002313 potential frameshift: common BLAST hit: gi|471336732|ref|YP_007609445.1| molybdenum cofactor biosynthesis protein A 1306400002314 hypothetical protein; Provisional; Region: PRK11770 1306400002315 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1306400002316 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1306400002317 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1306400002318 DNA-binding site [nucleotide binding]; DNA binding site 1306400002319 RNA-binding motif; other site 1306400002320 PE family; Region: PE; pfam00934 1306400002321 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400002322 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400002323 active site 1306400002324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1306400002325 FIST N domain; Region: FIST; pfam08495 1306400002326 FIST C domain; Region: FIST_C; pfam10442 1306400002327 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1306400002328 H+ Antiporter protein; Region: 2A0121; TIGR00900 1306400002329 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1306400002330 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400002331 PPE family; Region: PPE; pfam00823 1306400002332 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400002333 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400002334 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1306400002335 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306400002336 MarR family; Region: MarR; pfam01047 1306400002337 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1306400002338 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1306400002339 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1306400002340 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1306400002341 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1306400002342 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400002343 catalytic residue [active] 1306400002344 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1306400002345 Ferredoxin [Energy production and conversion]; Region: COG1146 1306400002346 4Fe-4S binding domain; Region: Fer4; pfam00037 1306400002347 ferredoxin-NADP+ reductase; Region: PLN02852 1306400002348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400002349 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1306400002350 putative dimer interface [polypeptide binding]; other site 1306400002351 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400002352 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1306400002353 dimer interface [polypeptide binding]; other site 1306400002354 Citrate synthase; Region: Citrate_synt; pfam00285 1306400002355 active site 1306400002356 citrylCoA binding site [chemical binding]; other site 1306400002357 oxalacetate/citrate binding site [chemical binding]; other site 1306400002358 coenzyme A binding site [chemical binding]; other site 1306400002359 catalytic triad [active] 1306400002360 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306400002361 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306400002362 DNA binding residues [nucleotide binding] 1306400002363 dimerization interface [polypeptide binding]; other site 1306400002364 Predicted ATPase [General function prediction only]; Region: COG3903 1306400002365 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400002366 cyclase homology domain; Region: CHD; cd07302 1306400002367 nucleotidyl binding site; other site 1306400002368 metal binding site [ion binding]; metal-binding site 1306400002369 dimer interface [polypeptide binding]; other site 1306400002370 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400002371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306400002372 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400002373 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400002374 AAA ATPase domain; Region: AAA_16; pfam13191 1306400002375 Predicted ATPase [General function prediction only]; Region: COG3903 1306400002376 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400002377 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400002378 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1306400002379 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1306400002380 dimer interface [polypeptide binding]; other site 1306400002381 active site 1306400002382 citrylCoA binding site [chemical binding]; other site 1306400002383 NADH binding [chemical binding]; other site 1306400002384 cationic pore residues; other site 1306400002385 oxalacetate/citrate binding site [chemical binding]; other site 1306400002386 coenzyme A binding site [chemical binding]; other site 1306400002387 catalytic triad [active] 1306400002388 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1306400002389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400002390 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1306400002391 BON domain; Region: BON; pfam04972 1306400002392 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1306400002393 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1306400002394 ligand binding site [chemical binding]; other site 1306400002395 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1306400002396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306400002397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400002398 dimerization interface [polypeptide binding]; other site 1306400002399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306400002400 dimer interface [polypeptide binding]; other site 1306400002401 phosphorylation site [posttranslational modification] 1306400002402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400002403 Mg2+ binding site [ion binding]; other site 1306400002404 G-X-G motif; other site 1306400002405 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400002406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400002407 active site 1306400002408 phosphorylation site [posttranslational modification] 1306400002409 intermolecular recognition site; other site 1306400002410 dimerization interface [polypeptide binding]; other site 1306400002411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400002412 DNA binding site [nucleotide binding] 1306400002413 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1306400002414 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1306400002415 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306400002416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400002417 substrate binding site [chemical binding]; other site 1306400002418 oxyanion hole (OAH) forming residues; other site 1306400002419 trimer interface [polypeptide binding]; other site 1306400002420 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1306400002421 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1306400002422 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400002423 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400002424 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1306400002425 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1306400002426 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400002427 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306400002428 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1306400002429 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1306400002430 hydrophobic ligand binding site; other site 1306400002431 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1306400002432 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400002433 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1306400002434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400002435 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1306400002436 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1306400002437 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1306400002438 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306400002439 active site 1306400002440 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400002441 PPE family; Region: PPE; pfam00823 1306400002442 PE family; Region: PE; pfam00934 1306400002443 BCCT family transporter; Region: BCCT; pfam02028 1306400002444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1306400002445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400002446 Coenzyme A binding pocket [chemical binding]; other site 1306400002447 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400002448 MULE transposase domain; Region: MULE; pfam10551 1306400002449 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306400002450 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1306400002451 catalytic residues [active] 1306400002452 catalytic nucleophile [active] 1306400002453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306400002454 Probable transposase; Region: OrfB_IS605; pfam01385 1306400002455 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1306400002456 putative active site pocket [active] 1306400002457 dimerization interface [polypeptide binding]; other site 1306400002458 putative catalytic residue [active] 1306400002459 Phage-related replication protein [General function prediction only]; Region: COG4195 1306400002460 manganese transport protein MntH; Reviewed; Region: PRK00701 1306400002461 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1306400002462 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1306400002463 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1306400002464 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1306400002465 short chain dehydrogenase; Provisional; Region: PRK07814 1306400002466 classical (c) SDRs; Region: SDR_c; cd05233 1306400002467 NAD(P) binding site [chemical binding]; other site 1306400002468 active site 1306400002469 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1306400002470 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1306400002471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400002472 dimer interface [polypeptide binding]; other site 1306400002473 conserved gate region; other site 1306400002474 putative PBP binding loops; other site 1306400002475 ABC-ATPase subunit interface; other site 1306400002476 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1306400002477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400002478 dimer interface [polypeptide binding]; other site 1306400002479 conserved gate region; other site 1306400002480 putative PBP binding loops; other site 1306400002481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1306400002482 ABC-ATPase subunit interface; other site 1306400002483 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400002484 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400002485 active site 1306400002486 ATP binding site [chemical binding]; other site 1306400002487 substrate binding site [chemical binding]; other site 1306400002488 activation loop (A-loop); other site 1306400002489 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306400002490 NHL repeat; Region: NHL; pfam01436 1306400002491 NHL repeat; Region: NHL; pfam01436 1306400002492 NHL repeat; Region: NHL; pfam01436 1306400002493 NHL repeat; Region: NHL; pfam01436 1306400002494 NHL repeat; Region: NHL; pfam01436 1306400002495 PBP superfamily domain; Region: PBP_like_2; cl17296 1306400002496 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1306400002497 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1306400002498 Walker A/P-loop; other site 1306400002499 ATP binding site [chemical binding]; other site 1306400002500 Q-loop/lid; other site 1306400002501 ABC transporter signature motif; other site 1306400002502 Walker B; other site 1306400002503 D-loop; other site 1306400002504 H-loop/switch region; other site 1306400002505 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1306400002506 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1306400002507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400002508 dimer interface [polypeptide binding]; other site 1306400002509 conserved gate region; other site 1306400002510 putative PBP binding loops; other site 1306400002511 ABC-ATPase subunit interface; other site 1306400002512 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1306400002513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400002514 dimer interface [polypeptide binding]; other site 1306400002515 conserved gate region; other site 1306400002516 putative PBP binding loops; other site 1306400002517 ABC-ATPase subunit interface; other site 1306400002518 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1306400002519 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1306400002520 putative DNA binding site [nucleotide binding]; other site 1306400002521 putative homodimer interface [polypeptide binding]; other site 1306400002522 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1306400002523 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1306400002524 nucleotide binding site [chemical binding]; other site 1306400002525 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1306400002526 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1306400002527 active site 1306400002528 DNA binding site [nucleotide binding] 1306400002529 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1306400002530 DNA binding site [nucleotide binding] 1306400002531 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1306400002532 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1306400002533 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306400002534 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1306400002535 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400002536 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306400002537 anti sigma factor interaction site; other site 1306400002538 regulatory phosphorylation site [posttranslational modification]; other site 1306400002539 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400002540 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1306400002541 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1306400002542 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1306400002543 short chain dehydrogenase; Provisional; Region: PRK08251 1306400002544 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1306400002545 putative NAD(P) binding site [chemical binding]; other site 1306400002546 active site 1306400002547 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1306400002548 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1306400002549 active site 1306400002550 dimer interface [polypeptide binding]; other site 1306400002551 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1306400002552 dimer interface [polypeptide binding]; other site 1306400002553 active site 1306400002554 Predicted esterase [General function prediction only]; Region: COG0627 1306400002555 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1306400002556 hypothetical protein; Provisional; Region: PRK07857 1306400002557 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1306400002558 Part of AAA domain; Region: AAA_19; pfam13245 1306400002559 Family description; Region: UvrD_C_2; pfam13538 1306400002560 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1306400002561 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1306400002562 Peptidase family M23; Region: Peptidase_M23; pfam01551 1306400002563 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1306400002564 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1306400002565 CoA-ligase; Region: Ligase_CoA; pfam00549 1306400002566 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1306400002567 CoA binding domain; Region: CoA_binding; smart00881 1306400002568 CoA-ligase; Region: Ligase_CoA; pfam00549 1306400002569 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1306400002570 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400002571 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1306400002572 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1306400002573 active site 1306400002574 substrate binding site [chemical binding]; other site 1306400002575 cosubstrate binding site; other site 1306400002576 catalytic site [active] 1306400002577 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1306400002578 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1306400002579 purine monophosphate binding site [chemical binding]; other site 1306400002580 dimer interface [polypeptide binding]; other site 1306400002581 putative catalytic residues [active] 1306400002582 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1306400002583 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1306400002584 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1306400002585 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1306400002586 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1306400002587 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1306400002588 metal ion-dependent adhesion site (MIDAS); other site 1306400002589 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1306400002590 homotetrameric interface [polypeptide binding]; other site 1306400002591 putative active site [active] 1306400002592 metal binding site [ion binding]; metal-binding site 1306400002593 potential frameshift: common BLAST hit: gi|471336835|ref|YP_007609548.1| lipoprotein 1306400002594 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1306400002595 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1306400002596 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1306400002597 putative homodimer interface [polypeptide binding]; other site 1306400002598 putative homotetramer interface [polypeptide binding]; other site 1306400002599 allosteric switch controlling residues; other site 1306400002600 putative metal binding site [ion binding]; other site 1306400002601 putative homodimer-homodimer interface [polypeptide binding]; other site 1306400002602 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1306400002603 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1306400002604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400002605 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306400002606 enoyl-CoA hydratase; Provisional; Region: PRK07827 1306400002607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400002608 substrate binding site [chemical binding]; other site 1306400002609 oxyanion hole (OAH) forming residues; other site 1306400002610 trimer interface [polypeptide binding]; other site 1306400002611 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400002612 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1306400002613 active site 1306400002614 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1306400002615 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306400002616 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306400002617 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1306400002618 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306400002619 carboxyltransferase (CT) interaction site; other site 1306400002620 biotinylation site [posttranslational modification]; other site 1306400002621 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306400002622 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306400002623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400002624 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400002625 active site 1306400002626 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1306400002627 PE family; Region: PE; pfam00934 1306400002628 PE family; Region: PE; pfam00934 1306400002629 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306400002630 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306400002631 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306400002632 PE family; Region: PE; pfam00934 1306400002633 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306400002634 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306400002635 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306400002636 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1306400002637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400002638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400002639 active site 1306400002640 phosphorylation site [posttranslational modification] 1306400002641 intermolecular recognition site; other site 1306400002642 dimerization interface [polypeptide binding]; other site 1306400002643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400002644 DNA binding site [nucleotide binding] 1306400002645 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1306400002646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400002647 dimerization interface [polypeptide binding]; other site 1306400002648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306400002649 dimer interface [polypeptide binding]; other site 1306400002650 phosphorylation site [posttranslational modification] 1306400002651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400002652 ATP binding site [chemical binding]; other site 1306400002653 Mg2+ binding site [ion binding]; other site 1306400002654 G-X-G motif; other site 1306400002655 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1306400002656 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306400002657 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1306400002658 MPT binding site; other site 1306400002659 trimer interface [polypeptide binding]; other site 1306400002660 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1306400002661 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1306400002662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1306400002663 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1306400002664 Walker A/P-loop; other site 1306400002665 ATP binding site [chemical binding]; other site 1306400002666 Q-loop/lid; other site 1306400002667 ABC transporter signature motif; other site 1306400002668 Walker B; other site 1306400002669 D-loop; other site 1306400002670 H-loop/switch region; other site 1306400002671 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1306400002672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1306400002673 FtsX-like permease family; Region: FtsX; pfam02687 1306400002674 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1306400002675 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1306400002676 FtsX-like permease family; Region: FtsX; pfam02687 1306400002677 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1306400002678 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306400002679 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306400002680 substrate binding pocket [chemical binding]; other site 1306400002681 chain length determination region; other site 1306400002682 substrate-Mg2+ binding site; other site 1306400002683 catalytic residues [active] 1306400002684 aspartate-rich region 1; other site 1306400002685 active site lid residues [active] 1306400002686 aspartate-rich region 2; other site 1306400002687 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1306400002688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1306400002689 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1306400002690 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1306400002691 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1306400002692 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1306400002693 active site 1306400002694 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1306400002695 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1306400002696 dimer interface [polypeptide binding]; other site 1306400002697 putative functional site; other site 1306400002698 putative MPT binding site; other site 1306400002699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1306400002700 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1306400002701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400002702 S-adenosylmethionine binding site [chemical binding]; other site 1306400002703 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306400002704 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306400002705 ligand binding site [chemical binding]; other site 1306400002706 flexible hinge region; other site 1306400002707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1306400002708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400002709 Coenzyme A binding pocket [chemical binding]; other site 1306400002710 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1306400002711 arginine deiminase; Provisional; Region: PRK01388 1306400002712 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1306400002713 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1306400002714 Predicted methyltransferases [General function prediction only]; Region: COG0313 1306400002715 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1306400002716 putative SAM binding site [chemical binding]; other site 1306400002717 putative homodimer interface [polypeptide binding]; other site 1306400002718 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1306400002719 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1306400002720 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1306400002721 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1306400002722 active site 1306400002723 HIGH motif; other site 1306400002724 KMSKS motif; other site 1306400002725 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1306400002726 tRNA binding surface [nucleotide binding]; other site 1306400002727 anticodon binding site; other site 1306400002728 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1306400002729 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1306400002730 active site 1306400002731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1306400002732 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1306400002733 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1306400002734 G5 domain; Region: G5; pfam07501 1306400002735 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306400002736 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1306400002737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400002738 S-adenosylmethionine binding site [chemical binding]; other site 1306400002739 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1306400002740 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1306400002741 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1306400002742 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1306400002743 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400002744 acyl-activating enzyme (AAE) consensus motif; other site 1306400002745 AMP binding site [chemical binding]; other site 1306400002746 active site 1306400002747 CoA binding site [chemical binding]; other site 1306400002748 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1306400002749 putative active site [active] 1306400002750 catalytic residue [active] 1306400002751 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1306400002752 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1306400002753 5S rRNA interface [nucleotide binding]; other site 1306400002754 CTC domain interface [polypeptide binding]; other site 1306400002755 L16 interface [polypeptide binding]; other site 1306400002756 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1306400002757 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1306400002758 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1306400002759 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400002760 active site 1306400002761 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1306400002762 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1306400002763 Substrate binding site; other site 1306400002764 Mg++ binding site; other site 1306400002765 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1306400002766 active site 1306400002767 substrate binding site [chemical binding]; other site 1306400002768 CoA binding site [chemical binding]; other site 1306400002769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400002770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400002771 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1306400002772 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1306400002773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306400002774 ATP binding site [chemical binding]; other site 1306400002775 putative Mg++ binding site [ion binding]; other site 1306400002776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400002777 nucleotide binding region [chemical binding]; other site 1306400002778 ATP-binding site [chemical binding]; other site 1306400002779 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1306400002780 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1306400002781 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1306400002782 homodimer interface [polypeptide binding]; other site 1306400002783 metal binding site [ion binding]; metal-binding site 1306400002784 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1306400002785 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1306400002786 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1306400002787 enolase; Provisional; Region: eno; PRK00077 1306400002788 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1306400002789 dimer interface [polypeptide binding]; other site 1306400002790 metal binding site [ion binding]; metal-binding site 1306400002791 substrate binding pocket [chemical binding]; other site 1306400002792 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1306400002793 Septum formation initiator; Region: DivIC; pfam04977 1306400002794 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1306400002795 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1306400002796 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1306400002797 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1306400002798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400002799 active site 1306400002800 phosphorylation site [posttranslational modification] 1306400002801 intermolecular recognition site; other site 1306400002802 dimerization interface [polypeptide binding]; other site 1306400002803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400002804 DNA binding site [nucleotide binding] 1306400002805 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1306400002806 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1306400002807 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1306400002808 Ligand Binding Site [chemical binding]; other site 1306400002809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306400002810 dimer interface [polypeptide binding]; other site 1306400002811 phosphorylation site [posttranslational modification] 1306400002812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400002813 ATP binding site [chemical binding]; other site 1306400002814 Mg2+ binding site [ion binding]; other site 1306400002815 G-X-G motif; other site 1306400002816 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1306400002817 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1306400002818 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400002819 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306400002820 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 1306400002821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306400002822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306400002823 dimer interface [polypeptide binding]; other site 1306400002824 phosphorylation site [posttranslational modification] 1306400002825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400002826 ATP binding site [chemical binding]; other site 1306400002827 Mg2+ binding site [ion binding]; other site 1306400002828 G-X-G motif; other site 1306400002829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400002830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400002831 active site 1306400002832 phosphorylation site [posttranslational modification] 1306400002833 intermolecular recognition site; other site 1306400002834 dimerization interface [polypeptide binding]; other site 1306400002835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400002836 DNA binding site [nucleotide binding] 1306400002837 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1306400002838 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1306400002839 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1306400002840 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306400002841 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1306400002842 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400002843 PPE family; Region: PPE; pfam00823 1306400002844 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400002845 PE family; Region: PE; pfam00934 1306400002846 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400002847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1306400002848 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1306400002849 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1306400002850 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1306400002851 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306400002852 Predicted transcriptional regulator [Transcription]; Region: COG5340 1306400002853 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306400002854 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400002855 MULE transposase domain; Region: MULE; pfam10551 1306400002856 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1306400002857 MarR family; Region: MarR_2; pfam12802 1306400002858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400002859 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306400002860 NAD(P) binding site [chemical binding]; other site 1306400002861 active site 1306400002862 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1306400002863 Helix-turn-helix domain; Region: HTH_17; pfam12728 1306400002864 Fic/DOC family; Region: Fic; pfam02661 1306400002865 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306400002866 Domain of unknown function (DUF427); Region: DUF427; cl00998 1306400002867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1306400002868 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400002869 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306400002870 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1306400002871 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1306400002872 dimer interface [polypeptide binding]; other site 1306400002873 acyl-activating enzyme (AAE) consensus motif; other site 1306400002874 putative active site [active] 1306400002875 AMP binding site [chemical binding]; other site 1306400002876 putative CoA binding site [chemical binding]; other site 1306400002877 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1306400002878 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1306400002879 hydrophobic ligand binding site; other site 1306400002880 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1306400002881 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1306400002882 putative active site [active] 1306400002883 putative dimer interface [polypeptide binding]; other site 1306400002884 Patatin-like phospholipase; Region: Patatin; pfam01734 1306400002885 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306400002886 nucleophile elbow; other site 1306400002887 hypothetical protein; Provisional; Region: PRK10279 1306400002888 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1306400002889 active site 1306400002890 nucleophile elbow; other site 1306400002891 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1306400002892 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1306400002893 active site residue [active] 1306400002894 PE family; Region: PE; pfam00934 1306400002895 PE family; Region: PE; pfam00934 1306400002896 Predicted membrane protein [Function unknown]; Region: COG4425 1306400002897 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1306400002898 enoyl-CoA hydratase; Provisional; Region: PRK05862 1306400002899 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400002900 substrate binding site [chemical binding]; other site 1306400002901 oxyanion hole (OAH) forming residues; other site 1306400002902 trimer interface [polypeptide binding]; other site 1306400002903 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1306400002904 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400002905 substrate binding site [chemical binding]; other site 1306400002906 oxyanion hole (OAH) forming residues; other site 1306400002907 trimer interface [polypeptide binding]; other site 1306400002908 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1306400002909 Predicted membrane protein [Function unknown]; Region: COG4760 1306400002910 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306400002911 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1306400002912 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1306400002913 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306400002914 dimer interface [polypeptide binding]; other site 1306400002915 active site 1306400002916 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1306400002917 active site 1306400002918 catalytic triad [active] 1306400002919 oxyanion hole [active] 1306400002920 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1306400002921 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1306400002922 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1306400002923 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1306400002924 dimer interface [polypeptide binding]; other site 1306400002925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400002926 catalytic residue [active] 1306400002927 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1306400002928 RDD family; Region: RDD; pfam06271 1306400002929 cystathionine gamma-synthase; Provisional; Region: PRK07811 1306400002930 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1306400002931 homodimer interface [polypeptide binding]; other site 1306400002932 substrate-cofactor binding pocket; other site 1306400002933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400002934 catalytic residue [active] 1306400002935 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1306400002936 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1306400002937 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1306400002938 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1306400002939 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1306400002940 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1306400002941 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1306400002942 catalytic residues [active] 1306400002943 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1306400002944 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1306400002945 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1306400002946 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1306400002947 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1306400002948 catalytic residue [active] 1306400002949 putative FPP diphosphate binding site; other site 1306400002950 putative FPP binding hydrophobic cleft; other site 1306400002951 dimer interface [polypeptide binding]; other site 1306400002952 putative IPP diphosphate binding site; other site 1306400002953 PE family; Region: PE; pfam00934 1306400002954 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1306400002955 putative IPP diphosphate binding site; other site 1306400002956 PE family; Region: PE; pfam00934 1306400002957 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1306400002958 PE family; Region: PE; pfam00934 1306400002959 pantothenate kinase; Provisional; Region: PRK05439 1306400002960 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1306400002961 ATP-binding site [chemical binding]; other site 1306400002962 CoA-binding site [chemical binding]; other site 1306400002963 Mg2+-binding site [ion binding]; other site 1306400002964 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1306400002965 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1306400002966 dimer interface [polypeptide binding]; other site 1306400002967 active site 1306400002968 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1306400002969 folate binding site [chemical binding]; other site 1306400002970 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1306400002971 dinuclear metal binding motif [ion binding]; other site 1306400002972 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1306400002973 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1306400002974 putative active site [active] 1306400002975 PhoH-like protein; Region: PhoH; pfam02562 1306400002976 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1306400002977 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1306400002978 NodB motif; other site 1306400002979 active site 1306400002980 catalytic site [active] 1306400002981 metal binding site [ion binding]; metal-binding site 1306400002982 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1306400002983 Class II fumarases; Region: Fumarase_classII; cd01362 1306400002984 active site 1306400002985 tetramer interface [polypeptide binding]; other site 1306400002986 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1306400002987 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1306400002988 putative active site [active] 1306400002989 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1306400002990 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1306400002991 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1306400002992 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306400002993 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1306400002994 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400002995 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400002996 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400002997 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1306400002998 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1306400002999 putative NAD(P) binding site [chemical binding]; other site 1306400003000 active site 1306400003001 putative substrate binding site [chemical binding]; other site 1306400003002 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1306400003003 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1306400003004 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1306400003005 generic binding surface II; other site 1306400003006 generic binding surface I; other site 1306400003007 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1306400003008 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1306400003009 GTP-binding protein YchF; Reviewed; Region: PRK09601 1306400003010 YchF GTPase; Region: YchF; cd01900 1306400003011 G1 box; other site 1306400003012 GTP/Mg2+ binding site [chemical binding]; other site 1306400003013 Switch I region; other site 1306400003014 G2 box; other site 1306400003015 Switch II region; other site 1306400003016 G3 box; other site 1306400003017 G4 box; other site 1306400003018 G5 box; other site 1306400003019 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1306400003020 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1306400003021 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1306400003022 putative active site [active] 1306400003023 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1306400003024 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400003025 cyclase homology domain; Region: CHD; cd07302 1306400003026 nucleotidyl binding site; other site 1306400003027 metal binding site [ion binding]; metal-binding site 1306400003028 dimer interface [polypeptide binding]; other site 1306400003029 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1306400003030 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1306400003031 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1306400003032 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1306400003033 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1306400003034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306400003035 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400003036 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400003037 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1306400003038 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1306400003039 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1306400003040 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400003041 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400003042 active site 1306400003043 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400003044 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306400003045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400003046 non-specific DNA binding site [nucleotide binding]; other site 1306400003047 salt bridge; other site 1306400003048 sequence-specific DNA binding site [nucleotide binding]; other site 1306400003049 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1306400003050 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1306400003051 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1306400003052 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1306400003053 citrate synthase; Provisional; Region: PRK14033 1306400003054 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1306400003055 oxalacetate binding site [chemical binding]; other site 1306400003056 citrylCoA binding site [chemical binding]; other site 1306400003057 coenzyme A binding site [chemical binding]; other site 1306400003058 catalytic triad [active] 1306400003059 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1306400003060 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1306400003061 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1306400003062 THF binding site; other site 1306400003063 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1306400003064 substrate binding site [chemical binding]; other site 1306400003065 THF binding site; other site 1306400003066 zinc-binding site [ion binding]; other site 1306400003067 PPE family; Region: PPE; pfam00823 1306400003068 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1306400003069 active site 1306400003070 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306400003071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400003072 substrate binding site [chemical binding]; other site 1306400003073 oxyanion hole (OAH) forming residues; other site 1306400003074 enoyl-CoA hydratase; Provisional; Region: PRK06494 1306400003075 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1306400003076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1306400003077 CAAX protease self-immunity; Region: Abi; pfam02517 1306400003078 enoyl-CoA hydratase; Provisional; Region: PRK06688 1306400003079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1306400003080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400003081 trimer interface [polypeptide binding]; other site 1306400003082 enoyl-CoA hydratase; Provisional; Region: PRK06688 1306400003083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400003084 substrate binding site [chemical binding]; other site 1306400003085 oxyanion hole (OAH) forming residues; other site 1306400003086 trimer interface [polypeptide binding]; other site 1306400003087 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306400003088 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306400003089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400003090 NAD(P) binding site [chemical binding]; other site 1306400003091 active site 1306400003092 MMPL family; Region: MMPL; pfam03176 1306400003093 MMPL family; Region: MMPL; pfam03176 1306400003094 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400003095 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400003096 active site 1306400003097 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1306400003098 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1306400003099 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1306400003100 NAD-dependent deacetylase; Provisional; Region: PRK00481 1306400003101 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1306400003102 NAD+ binding site [chemical binding]; other site 1306400003103 substrate binding site [chemical binding]; other site 1306400003104 Zn binding site [ion binding]; other site 1306400003105 Predicted transcriptional regulators [Transcription]; Region: COG1725 1306400003106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306400003107 DNA-binding site [nucleotide binding]; DNA binding site 1306400003108 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400003109 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1306400003110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1306400003111 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1306400003112 uncharacterized HhH-GPD family protein; Region: TIGR03252 1306400003113 minor groove reading motif; other site 1306400003114 helix-hairpin-helix signature motif; other site 1306400003115 mannosyltransferase; Provisional; Region: pimE; PRK13375 1306400003116 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1306400003117 aromatic arch; other site 1306400003118 DCoH dimer interaction site [polypeptide binding]; other site 1306400003119 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1306400003120 DCoH tetramer interaction site [polypeptide binding]; other site 1306400003121 substrate binding site [chemical binding]; other site 1306400003122 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1306400003123 active site 1306400003124 8-oxo-dGMP binding site [chemical binding]; other site 1306400003125 nudix motif; other site 1306400003126 metal binding site [ion binding]; metal-binding site 1306400003127 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1306400003128 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1306400003129 [4Fe-4S] binding site [ion binding]; other site 1306400003130 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306400003131 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306400003132 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306400003133 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1306400003134 molybdopterin cofactor binding site; other site 1306400003135 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1306400003136 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1306400003137 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1306400003138 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1306400003139 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1306400003140 G1 box; other site 1306400003141 putative GEF interaction site [polypeptide binding]; other site 1306400003142 GTP/Mg2+ binding site [chemical binding]; other site 1306400003143 Switch I region; other site 1306400003144 G2 box; other site 1306400003145 G3 box; other site 1306400003146 Switch II region; other site 1306400003147 G4 box; other site 1306400003148 G5 box; other site 1306400003149 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1306400003150 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1306400003151 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1306400003152 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1306400003153 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1306400003154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400003155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400003156 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400003157 PPE family; Region: PPE; pfam00823 1306400003158 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400003159 PE family; Region: PE; pfam00934 1306400003160 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1306400003161 PE family; Region: PE; pfam00934 1306400003162 FO synthase; Reviewed; Region: fbiC; PRK09234 1306400003163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400003164 FeS/SAM binding site; other site 1306400003165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400003166 FeS/SAM binding site; other site 1306400003167 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1306400003168 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1306400003169 active site 1306400003170 FMN binding site [chemical binding]; other site 1306400003171 2,4-decadienoyl-CoA binding site; other site 1306400003172 catalytic residue [active] 1306400003173 4Fe-4S cluster binding site [ion binding]; other site 1306400003174 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1306400003175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400003176 Predicted transcriptional regulators [Transcription]; Region: COG1695 1306400003177 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1306400003178 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1306400003179 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1306400003180 4Fe-4S binding domain; Region: Fer4; pfam00037 1306400003181 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1306400003182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400003183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400003184 homodimer interface [polypeptide binding]; other site 1306400003185 catalytic residue [active] 1306400003186 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1306400003187 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1306400003188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1306400003189 ATP binding site [chemical binding]; other site 1306400003190 putative Mg++ binding site [ion binding]; other site 1306400003191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1306400003192 ATP-binding site [chemical binding]; other site 1306400003193 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400003194 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400003195 active site 1306400003196 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400003197 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400003198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400003199 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400003200 Enoylreductase; Region: PKS_ER; smart00829 1306400003201 NAD(P) binding site [chemical binding]; other site 1306400003202 KR domain; Region: KR; pfam08659 1306400003203 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306400003204 putative NADP binding site [chemical binding]; other site 1306400003205 active site 1306400003206 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400003207 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306400003208 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306400003209 PE-PPE domain; Region: PE-PPE; pfam08237 1306400003210 acyl-CoA synthetase; Validated; Region: PRK05850 1306400003211 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400003212 acyl-activating enzyme (AAE) consensus motif; other site 1306400003213 active site 1306400003214 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306400003215 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306400003216 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1306400003217 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1306400003218 Glutamate binding site [chemical binding]; other site 1306400003219 NAD binding site [chemical binding]; other site 1306400003220 catalytic residues [active] 1306400003221 Proline dehydrogenase; Region: Pro_dh; pfam01619 1306400003222 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1306400003223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400003224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400003225 DNA binding residues [nucleotide binding] 1306400003226 haloalkane dehalogenase; Provisional; Region: PRK03204 1306400003227 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1306400003228 catalytic site [active] 1306400003229 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400003230 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1306400003231 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306400003232 PGAP1-like protein; Region: PGAP1; pfam07819 1306400003233 acyl-CoA synthetase; Validated; Region: PRK07787 1306400003234 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400003235 acyl-activating enzyme (AAE) consensus motif; other site 1306400003236 AMP binding site [chemical binding]; other site 1306400003237 active site 1306400003238 CoA binding site [chemical binding]; other site 1306400003239 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306400003240 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306400003241 PE family; Region: PE; pfam00934 1306400003242 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400003243 PPE family; Region: PPE; pfam00823 1306400003244 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400003245 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1306400003246 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306400003247 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400003248 MULE transposase domain; Region: MULE; pfam10551 1306400003249 metabolite-proton symporter; Region: 2A0106; TIGR00883 1306400003250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400003251 putative substrate translocation pore; other site 1306400003252 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1306400003253 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1306400003254 putative trimer interface [polypeptide binding]; other site 1306400003255 putative CoA binding site [chemical binding]; other site 1306400003256 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1306400003257 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1306400003258 metal binding site [ion binding]; metal-binding site 1306400003259 putative dimer interface [polypeptide binding]; other site 1306400003260 TIGR00730 family protein; Region: TIGR00730 1306400003261 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1306400003262 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1306400003263 acyl-activating enzyme (AAE) consensus motif; other site 1306400003264 putative AMP binding site [chemical binding]; other site 1306400003265 putative active site [active] 1306400003266 putative CoA binding site [chemical binding]; other site 1306400003267 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1306400003268 dihydropteroate synthase; Region: DHPS; TIGR01496 1306400003269 substrate binding pocket [chemical binding]; other site 1306400003270 dimer interface [polypeptide binding]; other site 1306400003271 inhibitor binding site; inhibition site 1306400003272 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1306400003273 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306400003274 DivIVA domain; Region: DivI1A_domain; TIGR03544 1306400003275 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1306400003276 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1306400003277 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1306400003278 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306400003279 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1306400003280 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1306400003281 ligand binding site; other site 1306400003282 oligomer interface; other site 1306400003283 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1306400003284 dimer interface [polypeptide binding]; other site 1306400003285 N-terminal domain interface [polypeptide binding]; other site 1306400003286 sulfate 1 binding site; other site 1306400003287 PE family; Region: PE; pfam00934 1306400003288 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1306400003289 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1306400003290 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1306400003291 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1306400003292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1306400003293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1306400003294 Walker A/P-loop; other site 1306400003295 ATP binding site [chemical binding]; other site 1306400003296 Q-loop/lid; other site 1306400003297 ABC transporter signature motif; other site 1306400003298 Walker B; other site 1306400003299 D-loop; other site 1306400003300 H-loop/switch region; other site 1306400003301 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1306400003302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400003303 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1306400003304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400003305 S-adenosylmethionine binding site [chemical binding]; other site 1306400003306 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1306400003307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400003308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400003309 DNA binding residues [nucleotide binding] 1306400003310 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1306400003311 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306400003312 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1306400003313 protein binding site [polypeptide binding]; other site 1306400003314 sec-independent translocase; Provisional; Region: PRK03100 1306400003315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400003316 active site 1306400003317 motif I; other site 1306400003318 motif II; other site 1306400003319 Predicted membrane protein [Function unknown]; Region: COG3428 1306400003320 Bacterial PH domain; Region: DUF304; pfam03703 1306400003321 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1306400003322 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1306400003323 Domain of unknown function DUF59; Region: DUF59; cl00941 1306400003324 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1306400003325 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1306400003326 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1306400003327 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1306400003328 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1306400003329 catalytic residue [active] 1306400003330 Predicted membrane protein [Function unknown]; Region: COG4420 1306400003331 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1306400003332 MgtE intracellular N domain; Region: MgtE_N; smart00924 1306400003333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1306400003334 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1306400003335 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1306400003336 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1306400003337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400003338 dimer interface [polypeptide binding]; other site 1306400003339 conserved gate region; other site 1306400003340 putative PBP binding loops; other site 1306400003341 ABC-ATPase subunit interface; other site 1306400003342 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1306400003343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400003344 dimer interface [polypeptide binding]; other site 1306400003345 conserved gate region; other site 1306400003346 ABC-ATPase subunit interface; other site 1306400003347 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1306400003348 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1306400003349 Walker A/P-loop; other site 1306400003350 ATP binding site [chemical binding]; other site 1306400003351 Q-loop/lid; other site 1306400003352 ABC transporter signature motif; other site 1306400003353 Walker B; other site 1306400003354 D-loop; other site 1306400003355 H-loop/switch region; other site 1306400003356 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1306400003357 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1306400003358 oligomer interface [polypeptide binding]; other site 1306400003359 metal binding site [ion binding]; metal-binding site 1306400003360 metal binding site [ion binding]; metal-binding site 1306400003361 putative Cl binding site [ion binding]; other site 1306400003362 basic sphincter; other site 1306400003363 hydrophobic gate; other site 1306400003364 periplasmic entrance; other site 1306400003365 malate dehydrogenase; Provisional; Region: PRK05442 1306400003366 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1306400003367 NAD(P) binding site [chemical binding]; other site 1306400003368 dimer interface [polypeptide binding]; other site 1306400003369 malate binding site [chemical binding]; other site 1306400003370 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400003371 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1306400003372 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1306400003373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400003374 NAD(P) binding site [chemical binding]; other site 1306400003375 active site 1306400003376 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1306400003377 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1306400003378 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1306400003379 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1306400003380 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1306400003381 TPP-binding site [chemical binding]; other site 1306400003382 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1306400003383 dimer interface [polypeptide binding]; other site 1306400003384 PYR/PP interface [polypeptide binding]; other site 1306400003385 TPP binding site [chemical binding]; other site 1306400003386 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306400003387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400003388 putative substrate translocation pore; other site 1306400003389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400003390 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1306400003391 RNase_H superfamily; Region: RNase_H_2; pfam13482 1306400003392 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1306400003393 Part of AAA domain; Region: AAA_19; pfam13245 1306400003394 AAA domain; Region: AAA_12; pfam13087 1306400003395 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1306400003396 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1306400003397 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1306400003398 ATP binding site [chemical binding]; other site 1306400003399 Mg++ binding site [ion binding]; other site 1306400003400 motif III; other site 1306400003401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400003402 nucleotide binding region [chemical binding]; other site 1306400003403 ATP-binding site [chemical binding]; other site 1306400003404 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1306400003405 putative RNA binding site [nucleotide binding]; other site 1306400003406 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1306400003407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400003408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400003409 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400003410 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400003411 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1306400003412 potential frameshift: common BLAST hit: gi|471337172|ref|YP_007609885.1| integral membrane transport protein 1306400003413 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1306400003414 Fe-S cluster binding site [ion binding]; other site 1306400003415 DNA binding site [nucleotide binding] 1306400003416 active site 1306400003417 hypothetical protein; Validated; Region: PRK05868 1306400003418 hypothetical protein; Provisional; Region: PRK07236 1306400003419 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306400003420 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306400003421 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1306400003422 HIT family signature motif; other site 1306400003423 catalytic residue [active] 1306400003424 amidase; Provisional; Region: PRK12470 1306400003425 Amidase; Region: Amidase; pfam01425 1306400003426 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400003427 cyclase homology domain; Region: CHD; cd07302 1306400003428 nucleotidyl binding site; other site 1306400003429 metal binding site [ion binding]; metal-binding site 1306400003430 dimer interface [polypeptide binding]; other site 1306400003431 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306400003432 potential frameshift: common BLAST hit: gi|433626364|ref|YP_007259993.1| Transmembrane serine/threonine-protein kinase H PknH (Protein 1306400003433 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1306400003434 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1306400003435 DNA binding site [nucleotide binding] 1306400003436 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306400003437 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306400003438 phosphopeptide binding site; other site 1306400003439 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1306400003440 putative active site [active] 1306400003441 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1306400003442 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1306400003443 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400003444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1306400003445 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1306400003446 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1306400003447 Walker A/P-loop; other site 1306400003448 ATP binding site [chemical binding]; other site 1306400003449 Q-loop/lid; other site 1306400003450 ABC transporter signature motif; other site 1306400003451 Walker B; other site 1306400003452 D-loop; other site 1306400003453 H-loop/switch region; other site 1306400003454 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1306400003455 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1306400003456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400003457 Walker A/P-loop; other site 1306400003458 ATP binding site [chemical binding]; other site 1306400003459 Q-loop/lid; other site 1306400003460 ABC transporter signature motif; other site 1306400003461 Walker B; other site 1306400003462 D-loop; other site 1306400003463 H-loop/switch region; other site 1306400003464 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1306400003465 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1306400003466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400003467 catalytic core [active] 1306400003468 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1306400003469 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1306400003470 active site 1306400003471 metal binding site [ion binding]; metal-binding site 1306400003472 DNA binding site [nucleotide binding] 1306400003473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400003474 Walker A/P-loop; other site 1306400003475 ATP binding site [chemical binding]; other site 1306400003476 choline dehydrogenase; Validated; Region: PRK02106 1306400003477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400003478 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1306400003479 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1306400003480 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1306400003481 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1306400003482 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1306400003483 Walker A/P-loop; other site 1306400003484 ATP binding site [chemical binding]; other site 1306400003485 Q-loop/lid; other site 1306400003486 ABC transporter signature motif; other site 1306400003487 Walker B; other site 1306400003488 D-loop; other site 1306400003489 H-loop/switch region; other site 1306400003490 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1306400003491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1306400003492 Walker A/P-loop; other site 1306400003493 ATP binding site [chemical binding]; other site 1306400003494 Q-loop/lid; other site 1306400003495 ABC transporter signature motif; other site 1306400003496 Walker B; other site 1306400003497 D-loop; other site 1306400003498 H-loop/switch region; other site 1306400003499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1306400003500 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1306400003501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400003502 dimer interface [polypeptide binding]; other site 1306400003503 conserved gate region; other site 1306400003504 putative PBP binding loops; other site 1306400003505 ABC-ATPase subunit interface; other site 1306400003506 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1306400003507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400003508 dimer interface [polypeptide binding]; other site 1306400003509 conserved gate region; other site 1306400003510 putative PBP binding loops; other site 1306400003511 ABC-ATPase subunit interface; other site 1306400003512 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1306400003513 active site clefts [active] 1306400003514 zinc binding site [ion binding]; other site 1306400003515 dimer interface [polypeptide binding]; other site 1306400003516 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1306400003517 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1306400003518 Active Sites [active] 1306400003519 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1306400003520 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1306400003521 CysD dimerization site [polypeptide binding]; other site 1306400003522 G1 box; other site 1306400003523 putative GEF interaction site [polypeptide binding]; other site 1306400003524 GTP/Mg2+ binding site [chemical binding]; other site 1306400003525 Switch I region; other site 1306400003526 G2 box; other site 1306400003527 G3 box; other site 1306400003528 Switch II region; other site 1306400003529 G4 box; other site 1306400003530 G5 box; other site 1306400003531 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1306400003532 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1306400003533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400003534 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1306400003535 Walker A/P-loop; other site 1306400003536 ligand-binding site [chemical binding]; other site 1306400003537 ATP binding site [chemical binding]; other site 1306400003538 Rrf2 family protein; Region: rrf2_super; TIGR00738 1306400003539 Transcriptional regulator; Region: Rrf2; pfam02082 1306400003540 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1306400003541 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1306400003542 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1306400003543 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1306400003544 Putative esterase; Region: Esterase; pfam00756 1306400003545 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1306400003546 Predicted membrane protein [Function unknown]; Region: COG4325 1306400003547 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1306400003548 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400003549 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1306400003550 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1306400003551 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1306400003552 active site 1306400003553 HIGH motif; other site 1306400003554 KMSK motif region; other site 1306400003555 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1306400003556 tRNA binding surface [nucleotide binding]; other site 1306400003557 anticodon binding site; other site 1306400003558 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1306400003559 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1306400003560 active site 1306400003561 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1306400003562 substrate binding site [chemical binding]; other site 1306400003563 catalytic residues [active] 1306400003564 dimer interface [polypeptide binding]; other site 1306400003565 homoserine dehydrogenase; Provisional; Region: PRK06349 1306400003566 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1306400003567 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1306400003568 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1306400003569 threonine synthase; Reviewed; Region: PRK06721 1306400003570 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1306400003571 homodimer interface [polypeptide binding]; other site 1306400003572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400003573 catalytic residue [active] 1306400003574 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1306400003575 transcription termination factor Rho; Provisional; Region: PRK12678 1306400003576 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1306400003577 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1306400003578 RNA binding site [nucleotide binding]; other site 1306400003579 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1306400003580 multimer interface [polypeptide binding]; other site 1306400003581 Walker A motif; other site 1306400003582 ATP binding site [chemical binding]; other site 1306400003583 Walker B motif; other site 1306400003584 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1306400003585 peptide chain release factor 1; Region: prfA; TIGR00019 1306400003586 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1306400003587 RF-1 domain; Region: RF-1; pfam00472 1306400003588 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1306400003589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400003590 S-adenosylmethionine binding site [chemical binding]; other site 1306400003591 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1306400003592 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1306400003593 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1306400003594 Mg++ binding site [ion binding]; other site 1306400003595 putative catalytic motif [active] 1306400003596 substrate binding site [chemical binding]; other site 1306400003597 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1306400003598 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1306400003599 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1306400003600 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1306400003601 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1306400003602 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1306400003603 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1306400003604 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1306400003605 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1306400003606 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1306400003607 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1306400003608 Walker A motif; other site 1306400003609 ATP binding site [chemical binding]; other site 1306400003610 Walker B motif; other site 1306400003611 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1306400003612 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1306400003613 core domain interface [polypeptide binding]; other site 1306400003614 delta subunit interface [polypeptide binding]; other site 1306400003615 epsilon subunit interface [polypeptide binding]; other site 1306400003616 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1306400003617 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1306400003618 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1306400003619 alpha subunit interaction interface [polypeptide binding]; other site 1306400003620 Walker A motif; other site 1306400003621 ATP binding site [chemical binding]; other site 1306400003622 Walker B motif; other site 1306400003623 inhibitor binding site; inhibition site 1306400003624 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1306400003625 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1306400003626 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1306400003627 gamma subunit interface [polypeptide binding]; other site 1306400003628 epsilon subunit interface [polypeptide binding]; other site 1306400003629 LBP interface [polypeptide binding]; other site 1306400003630 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1306400003631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306400003632 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306400003633 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1306400003634 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1306400003635 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1306400003636 hinge; other site 1306400003637 active site 1306400003638 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1306400003639 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1306400003640 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1306400003641 DNA binding site [nucleotide binding] 1306400003642 active site 1306400003643 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1306400003644 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1306400003645 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1306400003646 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1306400003647 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1306400003648 minor groove reading motif; other site 1306400003649 helix-hairpin-helix signature motif; other site 1306400003650 substrate binding pocket [chemical binding]; other site 1306400003651 active site 1306400003652 HAMP domain; Region: HAMP; pfam00672 1306400003653 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400003654 cyclase homology domain; Region: CHD; cd07302 1306400003655 nucleotidyl binding site; other site 1306400003656 metal binding site [ion binding]; metal-binding site 1306400003657 dimer interface [polypeptide binding]; other site 1306400003658 cyclase homology domain; Region: CHD; cd07302 1306400003659 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400003660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400003661 dimerization interface [polypeptide binding]; other site 1306400003662 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400003663 cyclase homology domain; Region: CHD; cd07302 1306400003664 metal binding site [ion binding]; metal-binding site 1306400003665 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1306400003666 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400003667 dimerization interface [polypeptide binding]; other site 1306400003668 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400003669 cyclase homology domain; Region: CHD; cd07302 1306400003670 nucleotidyl binding site; other site 1306400003671 metal binding site [ion binding]; metal-binding site 1306400003672 dimer interface [polypeptide binding]; other site 1306400003673 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1306400003674 hypothetical protein; Provisional; Region: PRK03298 1306400003675 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400003676 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1306400003677 dimer interface [polypeptide binding]; other site 1306400003678 substrate binding site [chemical binding]; other site 1306400003679 metal binding site [ion binding]; metal-binding site 1306400003680 putative acyltransferase; Provisional; Region: PRK05790 1306400003681 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306400003682 dimer interface [polypeptide binding]; other site 1306400003683 active site 1306400003684 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1306400003685 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1306400003686 PE family; Region: PE; pfam00934 1306400003687 glycogen branching enzyme; Provisional; Region: PRK05402 1306400003688 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1306400003689 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1306400003690 active site 1306400003691 catalytic site [active] 1306400003692 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1306400003693 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1306400003694 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1306400003695 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1306400003696 active site 1306400003697 homodimer interface [polypeptide binding]; other site 1306400003698 catalytic site [active] 1306400003699 acceptor binding site [chemical binding]; other site 1306400003700 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1306400003701 putative homodimer interface [polypeptide binding]; other site 1306400003702 putative active site pocket [active] 1306400003703 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1306400003704 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1306400003705 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1306400003706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1306400003707 putative Mg++ binding site [ion binding]; other site 1306400003708 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1306400003709 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1306400003710 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1306400003711 active site 1306400003712 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1306400003713 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1306400003714 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1306400003715 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1306400003716 putative active site pocket [active] 1306400003717 cleavage site 1306400003718 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1306400003719 MPN+ (JAMM) motif; other site 1306400003720 Zinc-binding site [ion binding]; other site 1306400003721 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1306400003722 MoaE interaction surface [polypeptide binding]; other site 1306400003723 MoeB interaction surface [polypeptide binding]; other site 1306400003724 thiocarboxylated glycine; other site 1306400003725 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1306400003726 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1306400003727 dimer interface [polypeptide binding]; other site 1306400003728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400003729 catalytic residue [active] 1306400003730 Rhomboid family; Region: Rhomboid; pfam01694 1306400003731 glutamate racemase; Provisional; Region: PRK00865 1306400003732 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1306400003733 ribonuclease PH; Reviewed; Region: rph; PRK00173 1306400003734 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1306400003735 hexamer interface [polypeptide binding]; other site 1306400003736 active site 1306400003737 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1306400003738 active site 1306400003739 dimerization interface [polypeptide binding]; other site 1306400003740 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1306400003741 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1306400003742 acyl carrier protein; Validated; Region: PRK05883 1306400003743 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1306400003744 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400003745 acyl-activating enzyme (AAE) consensus motif; other site 1306400003746 active site 1306400003747 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400003748 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400003749 active site 1306400003750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1306400003751 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1306400003752 potential frameshift: common BLAST hit: gi|471337271|ref|YP_007609984.1| drugs-transport transmembrane ATP-bindingprotein ABC transporter 1306400003753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400003754 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1306400003755 Walker A/P-loop; other site 1306400003756 ATP binding site [chemical binding]; other site 1306400003757 Q-loop/lid; other site 1306400003758 ABC transporter signature motif; other site 1306400003759 Walker B; other site 1306400003760 D-loop; other site 1306400003761 H-loop/switch region; other site 1306400003762 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1306400003763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400003764 NAD(P) binding site [chemical binding]; other site 1306400003765 active site 1306400003766 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1306400003767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400003768 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1306400003769 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1306400003770 GAF domain; Region: GAF; pfam01590 1306400003771 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1306400003772 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1306400003773 metal binding site [ion binding]; metal-binding site 1306400003774 active site 1306400003775 I-site; other site 1306400003776 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1306400003777 hypothetical protein; Provisional; Region: PRK07877 1306400003778 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1306400003779 ATP binding site [chemical binding]; other site 1306400003780 substrate interface [chemical binding]; other site 1306400003781 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306400003782 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1306400003783 Predicted ATPase [General function prediction only]; Region: COG3903 1306400003784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306400003785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306400003786 DNA binding residues [nucleotide binding] 1306400003787 dimerization interface [polypeptide binding]; other site 1306400003788 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400003789 cyclase homology domain; Region: CHD; cd07302 1306400003790 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1306400003791 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400003792 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400003793 PPE family; Region: PPE; pfam00823 1306400003794 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400003795 PAS fold; Region: PAS_4; pfam08448 1306400003796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1306400003797 putative active site [active] 1306400003798 heme pocket [chemical binding]; other site 1306400003799 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1306400003800 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1306400003801 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1306400003802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1306400003803 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306400003804 anti sigma factor interaction site; other site 1306400003805 regulatory phosphorylation site [posttranslational modification]; other site 1306400003806 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306400003807 anti sigma factor interaction site; other site 1306400003808 regulatory phosphorylation site [posttranslational modification]; other site 1306400003809 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1306400003810 synthetase active site [active] 1306400003811 NTP binding site [chemical binding]; other site 1306400003812 metal binding site [ion binding]; metal-binding site 1306400003813 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400003814 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400003815 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1306400003816 putative transposase OrfB; Reviewed; Region: PHA02517 1306400003817 HTH-like domain; Region: HTH_21; pfam13276 1306400003818 Integrase core domain; Region: rve; pfam00665 1306400003819 Integrase core domain; Region: rve_3; pfam13683 1306400003820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400003821 Transposase; Region: HTH_Tnp_1; cl17663 1306400003822 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1306400003823 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1306400003824 malonyl-CoA binding site [chemical binding]; other site 1306400003825 dimer interface [polypeptide binding]; other site 1306400003826 active site 1306400003827 product binding site; other site 1306400003828 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1306400003829 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1306400003830 uncharacterized domain; Region: TIGR00702 1306400003831 YcaO-like family; Region: YcaO; pfam02624 1306400003832 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1306400003833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400003834 S-adenosylmethionine binding site [chemical binding]; other site 1306400003835 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400003836 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400003837 active site 1306400003838 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1306400003839 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1306400003840 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1306400003841 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1306400003842 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1306400003843 dihydroorotase; Validated; Region: pyrC; PRK09357 1306400003844 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1306400003845 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1306400003846 active site 1306400003847 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1306400003848 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1306400003849 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1306400003850 catalytic site [active] 1306400003851 subunit interface [polypeptide binding]; other site 1306400003852 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1306400003853 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306400003854 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306400003855 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1306400003856 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306400003857 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306400003858 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1306400003859 IMP binding site; other site 1306400003860 dimer interface [polypeptide binding]; other site 1306400003861 interdomain contacts; other site 1306400003862 partial ornithine binding site; other site 1306400003863 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1306400003864 active site 1306400003865 dimer interface [polypeptide binding]; other site 1306400003866 PE family; Region: PE; pfam00934 1306400003867 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400003868 PPE family; Region: PPE; pfam00823 1306400003869 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1306400003870 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1306400003871 catalytic site [active] 1306400003872 G-X2-G-X-G-K; other site 1306400003873 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1306400003874 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1306400003875 Flavoprotein; Region: Flavoprotein; pfam02441 1306400003876 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1306400003877 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1306400003878 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1306400003879 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1306400003880 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1306400003881 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400003882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306400003883 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400003884 Cytochrome P450; Region: p450; cl12078 1306400003885 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1306400003886 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306400003887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306400003888 PE family; Region: PE; pfam00934 1306400003889 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1306400003890 oligomeric interface; other site 1306400003891 putative active site [active] 1306400003892 homodimer interface [polypeptide binding]; other site 1306400003893 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400003894 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400003895 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400003896 substrate binding pocket [chemical binding]; other site 1306400003897 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400003898 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400003899 substrate binding pocket [chemical binding]; other site 1306400003900 Predicted membrane protein [Function unknown]; Region: COG3714 1306400003901 primosome assembly protein PriA; Provisional; Region: PRK14873 1306400003902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400003903 S-adenosylmethionine binding site [chemical binding]; other site 1306400003904 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306400003905 MarR family; Region: MarR; pfam01047 1306400003906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400003907 S-adenosylmethionine binding site [chemical binding]; other site 1306400003908 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1306400003909 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1306400003910 putative active site [active] 1306400003911 substrate binding site [chemical binding]; other site 1306400003912 putative cosubstrate binding site; other site 1306400003913 catalytic site [active] 1306400003914 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1306400003915 substrate binding site [chemical binding]; other site 1306400003916 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1306400003917 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1306400003918 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1306400003919 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1306400003920 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1306400003921 substrate binding site [chemical binding]; other site 1306400003922 hexamer interface [polypeptide binding]; other site 1306400003923 metal binding site [ion binding]; metal-binding site 1306400003924 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1306400003925 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1306400003926 catalytic motif [active] 1306400003927 Zn binding site [ion binding]; other site 1306400003928 RibD C-terminal domain; Region: RibD_C; pfam01872 1306400003929 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306400003930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400003931 putative substrate translocation pore; other site 1306400003932 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1306400003933 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1306400003934 Lumazine binding domain; Region: Lum_binding; pfam00677 1306400003935 Lumazine binding domain; Region: Lum_binding; pfam00677 1306400003936 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1306400003937 catalytic residue [active] 1306400003938 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1306400003939 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1306400003940 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1306400003941 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1306400003942 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1306400003943 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1306400003944 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1306400003945 dimerization interface [polypeptide binding]; other site 1306400003946 active site 1306400003947 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1306400003948 homopentamer interface [polypeptide binding]; other site 1306400003949 active site 1306400003950 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1306400003951 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306400003952 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1306400003953 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1306400003954 putative sugar binding sites [chemical binding]; other site 1306400003955 Q-X-W motif; other site 1306400003956 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1306400003957 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1306400003958 GIY-YIG motif/motif A; other site 1306400003959 active site 1306400003960 catalytic site [active] 1306400003961 putative DNA binding site [nucleotide binding]; other site 1306400003962 metal binding site [ion binding]; metal-binding site 1306400003963 UvrB/uvrC motif; Region: UVR; pfam02151 1306400003964 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1306400003965 Helix-hairpin-helix motif; Region: HHH; pfam00633 1306400003966 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1306400003967 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1306400003968 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1306400003969 phosphate binding site [ion binding]; other site 1306400003970 putative substrate binding pocket [chemical binding]; other site 1306400003971 dimer interface [polypeptide binding]; other site 1306400003972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1306400003973 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1306400003974 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400003975 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400003976 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400003977 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306400003978 acyl-CoA synthetase; Provisional; Region: PRK13382 1306400003979 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1306400003980 acyl-activating enzyme (AAE) consensus motif; other site 1306400003981 putative AMP binding site [chemical binding]; other site 1306400003982 putative active site [active] 1306400003983 putative CoA binding site [chemical binding]; other site 1306400003984 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400003985 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1306400003986 putative acyl-acceptor binding pocket; other site 1306400003987 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306400003988 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306400003989 PE family; Region: PE; pfam00934 1306400003990 PE-PPE domain; Region: PE-PPE; pfam08237 1306400003991 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1306400003992 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1306400003993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400003994 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306400003995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306400003996 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306400003997 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1306400003998 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1306400003999 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1306400004000 Phosphoglycerate kinase; Region: PGK; pfam00162 1306400004001 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1306400004002 substrate binding site [chemical binding]; other site 1306400004003 hinge regions; other site 1306400004004 ADP binding site [chemical binding]; other site 1306400004005 catalytic site [active] 1306400004006 triosephosphate isomerase; Provisional; Region: PRK14567 1306400004007 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1306400004008 substrate binding site [chemical binding]; other site 1306400004009 dimer interface [polypeptide binding]; other site 1306400004010 catalytic triad [active] 1306400004011 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306400004012 Preprotein translocase SecG subunit; Region: SecG; cl09123 1306400004013 PE family; Region: PE; pfam00934 1306400004014 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1306400004015 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1306400004016 molybdopterin cofactor binding site [chemical binding]; other site 1306400004017 substrate binding site [chemical binding]; other site 1306400004018 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1306400004019 molybdopterin cofactor binding site; other site 1306400004020 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1306400004021 hydrophobic ligand binding site; other site 1306400004022 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1306400004023 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1306400004024 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1306400004025 putative active site [active] 1306400004026 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1306400004027 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1306400004028 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1306400004029 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1306400004030 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1306400004031 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1306400004032 putative active site [active] 1306400004033 transaldolase; Provisional; Region: PRK03903 1306400004034 catalytic residue [active] 1306400004035 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1306400004036 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1306400004037 TPP-binding site [chemical binding]; other site 1306400004038 dimer interface [polypeptide binding]; other site 1306400004039 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1306400004040 PYR/PP interface [polypeptide binding]; other site 1306400004041 dimer interface [polypeptide binding]; other site 1306400004042 TPP binding site [chemical binding]; other site 1306400004043 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1306400004044 UbiA prenyltransferase family; Region: UbiA; pfam01040 1306400004045 PE family; Region: PE; pfam00934 1306400004046 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306400004047 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306400004048 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1306400004049 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1306400004050 NADP binding site [chemical binding]; other site 1306400004051 dimer interface [polypeptide binding]; other site 1306400004052 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1306400004053 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1306400004054 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1306400004055 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1306400004056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1306400004057 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1306400004058 Walker A/P-loop; other site 1306400004059 ATP binding site [chemical binding]; other site 1306400004060 Q-loop/lid; other site 1306400004061 ABC transporter signature motif; other site 1306400004062 Walker B; other site 1306400004063 D-loop; other site 1306400004064 H-loop/switch region; other site 1306400004065 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1306400004066 Predicted transcriptional regulator [Transcription]; Region: COG2345 1306400004067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400004068 putative DNA binding site [nucleotide binding]; other site 1306400004069 putative Zn2+ binding site [ion binding]; other site 1306400004070 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1306400004071 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1306400004072 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1306400004073 protein-splicing catalytic site; other site 1306400004074 thioester formation/cholesterol transfer; other site 1306400004075 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1306400004076 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1306400004077 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1306400004078 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1306400004079 FeS assembly protein SufD; Region: sufD; TIGR01981 1306400004080 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1306400004081 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1306400004082 Walker A/P-loop; other site 1306400004083 ATP binding site [chemical binding]; other site 1306400004084 Q-loop/lid; other site 1306400004085 ABC transporter signature motif; other site 1306400004086 Walker B; other site 1306400004087 D-loop; other site 1306400004088 H-loop/switch region; other site 1306400004089 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1306400004090 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1306400004091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400004092 catalytic residue [active] 1306400004093 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1306400004094 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1306400004095 trimerization site [polypeptide binding]; other site 1306400004096 active site 1306400004097 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1306400004098 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1306400004099 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1306400004100 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400004101 active site 1306400004102 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1306400004103 PE family; Region: PE; pfam00934 1306400004104 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1306400004105 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400004106 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1306400004107 catalytic residues [active] 1306400004108 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1306400004109 catalytic residues [active] 1306400004110 enoyl-CoA hydratase; Provisional; Region: PRK05864 1306400004111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400004112 substrate binding site [chemical binding]; other site 1306400004113 oxyanion hole (OAH) forming residues; other site 1306400004114 trimer interface [polypeptide binding]; other site 1306400004115 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1306400004116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400004117 Walker A/P-loop; other site 1306400004118 ATP binding site [chemical binding]; other site 1306400004119 Q-loop/lid; other site 1306400004120 ABC transporter signature motif; other site 1306400004121 Walker B; other site 1306400004122 D-loop; other site 1306400004123 H-loop/switch region; other site 1306400004124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306400004125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400004126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400004127 aconitate hydratase; Validated; Region: PRK09277 1306400004128 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1306400004129 substrate binding site [chemical binding]; other site 1306400004130 ligand binding site [chemical binding]; other site 1306400004131 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1306400004132 substrate binding site [chemical binding]; other site 1306400004133 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306400004134 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306400004135 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306400004136 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306400004137 MoxR-like ATPases [General function prediction only]; Region: COG0714 1306400004138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400004139 Walker A motif; other site 1306400004140 ATP binding site [chemical binding]; other site 1306400004141 Walker B motif; other site 1306400004142 arginine finger; other site 1306400004143 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1306400004144 Protein of unknown function DUF58; Region: DUF58; pfam01882 1306400004145 hypothetical protein; Provisional; Region: PRK13685 1306400004146 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1306400004147 metal ion-dependent adhesion site (MIDAS); other site 1306400004148 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306400004149 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1306400004150 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1306400004151 NAD(P) binding site [chemical binding]; other site 1306400004152 homotetramer interface [polypeptide binding]; other site 1306400004153 homodimer interface [polypeptide binding]; other site 1306400004154 active site 1306400004155 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1306400004156 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1306400004157 NAD binding site [chemical binding]; other site 1306400004158 homotetramer interface [polypeptide binding]; other site 1306400004159 homodimer interface [polypeptide binding]; other site 1306400004160 substrate binding site [chemical binding]; other site 1306400004161 active site 1306400004162 ferrochelatase; Reviewed; Region: hemH; PRK00035 1306400004163 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1306400004164 C-terminal domain interface [polypeptide binding]; other site 1306400004165 active site 1306400004166 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1306400004167 active site 1306400004168 N-terminal domain interface [polypeptide binding]; other site 1306400004169 potential frameshift: common BLAST hit: gi|433641638|ref|YP_007287397.1| Conserved membrane protein of unknown function 1306400004170 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1306400004171 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1306400004172 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1306400004173 Transposase domain (DUF772); Region: DUF772; pfam05598 1306400004174 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1306400004175 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1306400004176 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1306400004177 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1306400004178 heterodimer interface [polypeptide binding]; other site 1306400004179 substrate interaction site [chemical binding]; other site 1306400004180 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1306400004181 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1306400004182 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1306400004183 active site 1306400004184 substrate binding site [chemical binding]; other site 1306400004185 coenzyme B12 binding site [chemical binding]; other site 1306400004186 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1306400004187 B12 binding site [chemical binding]; other site 1306400004188 cobalt ligand [ion binding]; other site 1306400004189 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306400004190 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1306400004191 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1306400004192 Walker A; other site 1306400004193 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400004194 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400004195 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306400004196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400004197 S-adenosylmethionine binding site [chemical binding]; other site 1306400004198 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1306400004199 NUDIX domain; Region: NUDIX; pfam00293 1306400004200 nudix motif; other site 1306400004201 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1306400004202 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1306400004203 Ligand binding site; other site 1306400004204 Putative Catalytic site; other site 1306400004205 DXD motif; other site 1306400004206 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1306400004207 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1306400004208 active site 1306400004209 potential frameshift: common BLAST hit: gi|433641656|ref|YP_007287415.1| Lipopolysaccharide biosynthesis protein RffA 1306400004210 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1306400004211 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1306400004212 putative trimer interface [polypeptide binding]; other site 1306400004213 putative CoA binding site [chemical binding]; other site 1306400004214 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1306400004215 S-adenosylmethionine binding site [chemical binding]; other site 1306400004216 WbqC-like protein family; Region: WbqC; pfam08889 1306400004217 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1306400004218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400004219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400004220 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400004221 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1306400004222 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1306400004223 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1306400004224 NADP-binding site; other site 1306400004225 homotetramer interface [polypeptide binding]; other site 1306400004226 substrate binding site [chemical binding]; other site 1306400004227 homodimer interface [polypeptide binding]; other site 1306400004228 active site 1306400004229 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1306400004230 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1306400004231 NADP binding site [chemical binding]; other site 1306400004232 active site 1306400004233 putative substrate binding site [chemical binding]; other site 1306400004234 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1306400004235 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1306400004236 metal-binding site 1306400004237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400004238 S-adenosylmethionine binding site [chemical binding]; other site 1306400004239 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306400004240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306400004241 active site 1306400004242 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1306400004243 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306400004244 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1306400004245 active site 1306400004246 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1306400004247 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306400004248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306400004249 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306400004250 active site 1306400004251 acyl-CoA synthetase; Validated; Region: PRK05850 1306400004252 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400004253 acyl-activating enzyme (AAE) consensus motif; other site 1306400004254 active site 1306400004255 Transport protein; Region: actII; TIGR00833 1306400004256 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400004257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400004258 S-adenosylmethionine binding site [chemical binding]; other site 1306400004259 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306400004260 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1306400004261 homodimer interface [polypeptide binding]; other site 1306400004262 active site 1306400004263 TDP-binding site; other site 1306400004264 acceptor substrate-binding pocket; other site 1306400004265 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1306400004266 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1306400004267 Probable Catalytic site; other site 1306400004268 metal-binding site 1306400004269 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306400004270 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1306400004271 homodimer interface [polypeptide binding]; other site 1306400004272 active site 1306400004273 TDP-binding site; other site 1306400004274 acceptor substrate-binding pocket; other site 1306400004275 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400004276 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400004277 active site 1306400004278 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1306400004279 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400004280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400004281 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400004282 Enoylreductase; Region: PKS_ER; smart00829 1306400004283 NAD(P) binding site [chemical binding]; other site 1306400004284 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306400004285 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306400004286 putative NADP binding site [chemical binding]; other site 1306400004287 active site 1306400004288 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400004289 acyl-CoA synthetase; Validated; Region: PRK05850 1306400004290 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400004291 acyl-activating enzyme (AAE) consensus motif; other site 1306400004292 active site 1306400004293 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1306400004294 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306400004295 NAD(P) binding site [chemical binding]; other site 1306400004296 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1306400004297 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1306400004298 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1306400004299 CoenzymeA binding site [chemical binding]; other site 1306400004300 subunit interaction site [polypeptide binding]; other site 1306400004301 PHB binding site; other site 1306400004302 Nitronate monooxygenase; Region: NMO; pfam03060 1306400004303 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306400004304 FMN binding site [chemical binding]; other site 1306400004305 substrate binding site [chemical binding]; other site 1306400004306 putative catalytic residue [active] 1306400004307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400004308 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1306400004309 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1306400004310 HIGH motif; other site 1306400004311 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1306400004312 active site 1306400004313 KMSKS motif; other site 1306400004314 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1306400004315 tRNA binding surface [nucleotide binding]; other site 1306400004316 anticodon binding site; other site 1306400004317 DNA polymerase IV; Provisional; Region: PRK03348 1306400004318 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1306400004319 active site 1306400004320 DNA binding site [nucleotide binding] 1306400004321 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1306400004322 active site 1306400004323 homodimer interface [polypeptide binding]; other site 1306400004324 homotetramer interface [polypeptide binding]; other site 1306400004325 lipoprotein signal peptidase; Provisional; Region: PRK14764 1306400004326 lipoprotein signal peptidase; Provisional; Region: PRK14787 1306400004327 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1306400004328 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1306400004329 active site 1306400004330 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1306400004331 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1306400004332 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1306400004333 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1306400004334 apolar tunnel; other site 1306400004335 heme binding site [chemical binding]; other site 1306400004336 dimerization interface [polypeptide binding]; other site 1306400004337 short chain dehydrogenase; Provisional; Region: PRK05866 1306400004338 classical (c) SDRs; Region: SDR_c; cd05233 1306400004339 NAD(P) binding site [chemical binding]; other site 1306400004340 active site 1306400004341 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1306400004342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400004343 NAD(P) binding site [chemical binding]; other site 1306400004344 active site 1306400004345 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1306400004346 hydrophobic ligand binding site; other site 1306400004347 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1306400004348 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1306400004349 active site 1306400004350 PHP Thumb interface [polypeptide binding]; other site 1306400004351 metal binding site [ion binding]; metal-binding site 1306400004352 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1306400004353 generic binding surface II; other site 1306400004354 generic binding surface I; other site 1306400004355 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400004356 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400004357 PPE family; Region: PPE; pfam00823 1306400004358 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400004359 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1306400004360 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1306400004361 acyl-activating enzyme (AAE) consensus motif; other site 1306400004362 putative AMP binding site [chemical binding]; other site 1306400004363 putative active site [active] 1306400004364 putative CoA binding site [chemical binding]; other site 1306400004365 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1306400004366 putative acyl-acceptor binding pocket; other site 1306400004367 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1306400004368 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1306400004369 L-aspartate oxidase; Provisional; Region: PRK06175 1306400004370 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1306400004371 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1306400004372 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1306400004373 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1306400004374 D-subunit interface [polypeptide binding]; other site 1306400004375 Iron-sulfur protein interface; other site 1306400004376 proximal quinone binding site [chemical binding]; other site 1306400004377 distal quinone binding site [chemical binding]; other site 1306400004378 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1306400004379 Iron-sulfur protein interface; other site 1306400004380 proximal quinone binding site [chemical binding]; other site 1306400004381 C-subunit interface; other site 1306400004382 distal quinone binding site; other site 1306400004383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400004384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400004385 MMPL family; Region: MMPL; pfam03176 1306400004386 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306400004387 threonine dehydratase; Validated; Region: PRK08639 1306400004388 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1306400004389 tetramer interface [polypeptide binding]; other site 1306400004390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400004391 catalytic residue [active] 1306400004392 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1306400004393 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306400004394 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306400004395 putative active site [active] 1306400004396 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1306400004397 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1306400004398 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1306400004399 catalytic site [active] 1306400004400 active site 1306400004401 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1306400004402 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1306400004403 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1306400004404 active site 1306400004405 catalytic site [active] 1306400004406 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1306400004407 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1306400004408 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1306400004409 active site 1306400004410 catalytic site [active] 1306400004411 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1306400004412 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306400004413 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306400004414 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1306400004415 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306400004416 inhibitor-cofactor binding pocket; inhibition site 1306400004417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400004418 catalytic residue [active] 1306400004419 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1306400004420 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1306400004421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400004422 catalytic residue [active] 1306400004423 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1306400004424 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1306400004425 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1306400004426 Phage capsid family; Region: Phage_capsid; pfam05065 1306400004427 Phage head maturation protease [General function prediction only]; Region: COG3740 1306400004428 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 1306400004429 Phage associated DNA primase [General function prediction only]; Region: COG3378 1306400004430 D5 N terminal like; Region: D5_N; smart00885 1306400004431 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1306400004432 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1306400004433 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1306400004434 catalytic residues [active] 1306400004435 Recombinase; Region: Recombinase; pfam07508 1306400004436 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1306400004437 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400004438 biotin synthase; Validated; Region: PRK06256 1306400004439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400004440 FeS/SAM binding site; other site 1306400004441 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1306400004442 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1306400004443 Secretory lipase; Region: LIP; pfam03583 1306400004444 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1306400004445 nudix motif; other site 1306400004446 quinolinate synthetase; Provisional; Region: PRK09375 1306400004447 L-aspartate oxidase; Provisional; Region: PRK07804 1306400004448 L-aspartate oxidase; Provisional; Region: PRK06175 1306400004449 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1306400004450 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1306400004451 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1306400004452 dimerization interface [polypeptide binding]; other site 1306400004453 active site 1306400004454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400004455 S-adenosylmethionine binding site [chemical binding]; other site 1306400004456 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1306400004457 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1306400004458 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1306400004459 NAD binding site [chemical binding]; other site 1306400004460 dimerization interface [polypeptide binding]; other site 1306400004461 product binding site; other site 1306400004462 substrate binding site [chemical binding]; other site 1306400004463 zinc binding site [ion binding]; other site 1306400004464 catalytic residues [active] 1306400004465 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1306400004466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400004468 homodimer interface [polypeptide binding]; other site 1306400004469 catalytic residue [active] 1306400004470 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1306400004471 4-fold oligomerization interface [polypeptide binding]; other site 1306400004472 putative active site pocket [active] 1306400004473 metal binding residues [ion binding]; metal-binding site 1306400004474 3-fold/trimer interface [polypeptide binding]; other site 1306400004475 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1306400004476 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1306400004477 putative active site [active] 1306400004478 oxyanion strand; other site 1306400004479 catalytic triad [active] 1306400004480 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1306400004481 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1306400004482 catalytic residues [active] 1306400004483 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1306400004484 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1306400004485 active site 1306400004486 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1306400004487 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1306400004488 substrate binding site [chemical binding]; other site 1306400004489 glutamase interaction surface [polypeptide binding]; other site 1306400004490 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1306400004491 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1306400004492 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1306400004493 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1306400004494 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1306400004495 catalytic triad [active] 1306400004496 anthranilate synthase component I; Provisional; Region: PRK13571 1306400004497 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1306400004498 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1306400004499 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1306400004500 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1306400004501 active site 1306400004502 ribulose/triose binding site [chemical binding]; other site 1306400004503 phosphate binding site [ion binding]; other site 1306400004504 substrate (anthranilate) binding pocket [chemical binding]; other site 1306400004505 product (indole) binding pocket [chemical binding]; other site 1306400004506 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1306400004507 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1306400004508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400004509 catalytic residue [active] 1306400004510 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1306400004511 substrate binding site [chemical binding]; other site 1306400004512 active site 1306400004513 catalytic residues [active] 1306400004514 heterodimer interface [polypeptide binding]; other site 1306400004515 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1306400004516 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1306400004517 TM2 domain; Region: TM2; pfam05154 1306400004518 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1306400004519 pyruvate kinase; Provisional; Region: PRK06247 1306400004520 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1306400004521 domain interfaces; other site 1306400004522 active site 1306400004523 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1306400004524 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1306400004525 active site 1306400004526 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1306400004527 catalytic triad [active] 1306400004528 dimer interface [polypeptide binding]; other site 1306400004529 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1306400004530 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1306400004531 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1306400004532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400004533 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1306400004534 Walker A/P-loop; other site 1306400004535 Walker A/P-loop; other site 1306400004536 ATP binding site [chemical binding]; other site 1306400004537 ATP binding site [chemical binding]; other site 1306400004538 Q-loop/lid; other site 1306400004539 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1306400004540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400004541 Walker A/P-loop; other site 1306400004542 ATP binding site [chemical binding]; other site 1306400004543 Q-loop/lid; other site 1306400004544 ABC transporter signature motif; other site 1306400004545 Walker B; other site 1306400004546 D-loop; other site 1306400004547 H-loop/switch region; other site 1306400004548 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1306400004549 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1306400004550 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1306400004551 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1306400004552 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1306400004553 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1306400004554 cyclase homology domain; Region: CHD; cd07302 1306400004555 nucleotidyl binding site; other site 1306400004556 metal binding site [ion binding]; metal-binding site 1306400004557 dimer interface [polypeptide binding]; other site 1306400004558 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1306400004559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400004560 active site 1306400004561 phosphorylation site [posttranslational modification] 1306400004562 intermolecular recognition site; other site 1306400004563 dimerization interface [polypeptide binding]; other site 1306400004564 ANTAR domain; Region: ANTAR; pfam03861 1306400004565 lipid-transfer protein; Provisional; Region: PRK06059 1306400004566 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306400004567 active site 1306400004568 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1306400004569 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1306400004570 DUF35 OB-fold domain; Region: DUF35; pfam01796 1306400004571 DNA polymerase I; Provisional; Region: PRK05755 1306400004572 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1306400004573 active site 1306400004574 metal binding site 1 [ion binding]; metal-binding site 1306400004575 putative 5' ssDNA interaction site; other site 1306400004576 metal binding site 3; metal-binding site 1306400004577 metal binding site 2 [ion binding]; metal-binding site 1306400004578 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1306400004579 putative DNA binding site [nucleotide binding]; other site 1306400004580 putative metal binding site [ion binding]; other site 1306400004581 3'-5' exonuclease; Region: 35EXOc; smart00474 1306400004582 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1306400004583 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1306400004584 active site 1306400004585 DNA binding site [nucleotide binding] 1306400004586 catalytic site [active] 1306400004587 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1306400004588 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1306400004589 RNA binding site [nucleotide binding]; other site 1306400004590 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1306400004591 RNA binding site [nucleotide binding]; other site 1306400004592 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1306400004593 RNA binding site [nucleotide binding]; other site 1306400004594 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1306400004595 RNA binding site [nucleotide binding]; other site 1306400004596 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1306400004597 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1306400004598 CoA-binding site [chemical binding]; other site 1306400004599 ATP-binding [chemical binding]; other site 1306400004600 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1306400004601 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1306400004602 excinuclease ABC subunit B; Provisional; Region: PRK05298 1306400004603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306400004604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400004605 nucleotide binding region [chemical binding]; other site 1306400004606 ATP-binding site [chemical binding]; other site 1306400004607 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1306400004608 UvrB/uvrC motif; Region: UVR; pfam02151 1306400004609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400004610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306400004611 putative substrate translocation pore; other site 1306400004612 Predicted membrane protein [Function unknown]; Region: COG5305 1306400004613 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400004614 Ligand Binding Site [chemical binding]; other site 1306400004615 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306400004616 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1306400004617 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1306400004618 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1306400004619 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1306400004620 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1306400004621 potential frameshift: common BLAST hit: gi|433626732|ref|YP_007260361.1| Conserved membrane protein of unknown function 1306400004622 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1306400004623 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1306400004624 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1306400004625 dimer interface [polypeptide binding]; other site 1306400004626 putative anticodon binding site; other site 1306400004627 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306400004628 motif 1; other site 1306400004629 dimer interface [polypeptide binding]; other site 1306400004630 active site 1306400004631 motif 2; other site 1306400004632 motif 3; other site 1306400004633 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1306400004634 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1306400004635 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1306400004636 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1306400004637 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1306400004638 23S rRNA binding site [nucleotide binding]; other site 1306400004639 L21 binding site [polypeptide binding]; other site 1306400004640 L13 binding site [polypeptide binding]; other site 1306400004641 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1306400004642 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1306400004643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1306400004644 PE family; Region: PE; pfam00934 1306400004645 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400004646 cyclase homology domain; Region: CHD; cd07302 1306400004647 nucleotidyl binding site; other site 1306400004648 metal binding site [ion binding]; metal-binding site 1306400004649 dimer interface [polypeptide binding]; other site 1306400004650 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1306400004651 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1306400004652 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1306400004653 dimer interface [polypeptide binding]; other site 1306400004654 motif 1; other site 1306400004655 active site 1306400004656 motif 2; other site 1306400004657 motif 3; other site 1306400004658 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1306400004659 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1306400004660 putative tRNA-binding site [nucleotide binding]; other site 1306400004661 B3/4 domain; Region: B3_4; pfam03483 1306400004662 tRNA synthetase B5 domain; Region: B5; smart00874 1306400004663 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1306400004664 dimer interface [polypeptide binding]; other site 1306400004665 motif 1; other site 1306400004666 motif 3; other site 1306400004667 motif 2; other site 1306400004668 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1306400004669 PE family; Region: PE; pfam00934 1306400004670 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1306400004671 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1306400004672 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1306400004673 heterotetramer interface [polypeptide binding]; other site 1306400004674 active site pocket [active] 1306400004675 cleavage site 1306400004676 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1306400004677 feedback inhibition sensing region; other site 1306400004678 homohexameric interface [polypeptide binding]; other site 1306400004679 nucleotide binding site [chemical binding]; other site 1306400004680 N-acetyl-L-glutamate binding site [chemical binding]; other site 1306400004681 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1306400004682 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306400004683 inhibitor-cofactor binding pocket; inhibition site 1306400004684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400004685 catalytic residue [active] 1306400004686 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1306400004687 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1306400004688 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1306400004689 arginine repressor; Provisional; Region: PRK03341 1306400004690 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1306400004691 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1306400004692 argininosuccinate synthase; Provisional; Region: PRK13820 1306400004693 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1306400004694 ANP binding site [chemical binding]; other site 1306400004695 Substrate Binding Site II [chemical binding]; other site 1306400004696 Substrate Binding Site I [chemical binding]; other site 1306400004697 argininosuccinate lyase; Provisional; Region: PRK00855 1306400004698 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1306400004699 active sites [active] 1306400004700 tetramer interface [polypeptide binding]; other site 1306400004701 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1306400004702 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1306400004703 malonyl-CoA binding site [chemical binding]; other site 1306400004704 dimer interface [polypeptide binding]; other site 1306400004705 active site 1306400004706 product binding site; other site 1306400004707 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400004708 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400004709 active site 1306400004710 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400004711 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400004712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400004713 Enoylreductase; Region: PKS_ER; smart00829 1306400004714 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400004715 NAD(P) binding site [chemical binding]; other site 1306400004716 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1306400004717 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306400004718 putative NADP binding site [chemical binding]; other site 1306400004719 active site 1306400004720 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400004721 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400004722 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400004723 active site 1306400004724 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400004725 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400004726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400004727 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400004728 Enoylreductase; Region: PKS_ER; smart00829 1306400004729 NAD(P) binding site [chemical binding]; other site 1306400004730 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306400004731 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1306400004732 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306400004733 putative NADP binding site [chemical binding]; other site 1306400004734 active site 1306400004735 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400004736 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306400004737 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400004738 active site 1306400004739 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306400004740 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400004741 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400004742 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1306400004743 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1306400004744 malonyl-CoA binding site [chemical binding]; other site 1306400004745 dimer interface [polypeptide binding]; other site 1306400004746 active site 1306400004747 product binding site; other site 1306400004748 Cytochrome P450; Region: p450; cl12078 1306400004749 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400004750 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1306400004751 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306400004752 ABC transporter; Region: ABC_tran_2; pfam12848 1306400004753 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306400004754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1306400004755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400004756 putative substrate translocation pore; other site 1306400004757 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306400004758 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1306400004759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400004760 dimerization interface [polypeptide binding]; other site 1306400004761 putative DNA binding site [nucleotide binding]; other site 1306400004762 putative Zn2+ binding site [ion binding]; other site 1306400004763 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1306400004764 active site residue [active] 1306400004765 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306400004766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306400004767 ligand binding site [chemical binding]; other site 1306400004768 flexible hinge region; other site 1306400004769 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1306400004770 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1306400004771 putative catalytic residues [active] 1306400004772 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1306400004773 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306400004774 catalytic residues [active] 1306400004775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400004776 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400004777 active site 1306400004778 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1306400004779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1306400004780 substrate binding pocket [chemical binding]; other site 1306400004781 membrane-bound complex binding site; other site 1306400004782 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1306400004783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400004784 FeS/SAM binding site; other site 1306400004785 DivIVA protein; Region: DivIVA; pfam05103 1306400004786 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1306400004787 acyl-CoA synthetase; Validated; Region: PRK07868 1306400004788 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1306400004789 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400004790 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400004791 acyl-activating enzyme (AAE) consensus motif; other site 1306400004792 AMP binding site [chemical binding]; other site 1306400004793 active site 1306400004794 CoA binding site [chemical binding]; other site 1306400004795 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1306400004796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400004797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400004798 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1306400004799 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1306400004800 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1306400004801 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1306400004802 Walker A/P-loop; other site 1306400004803 ATP binding site [chemical binding]; other site 1306400004804 Q-loop/lid; other site 1306400004805 ABC transporter signature motif; other site 1306400004806 Walker B; other site 1306400004807 D-loop; other site 1306400004808 H-loop/switch region; other site 1306400004809 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1306400004810 active site 1306400004811 DNA binding site [nucleotide binding] 1306400004812 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1306400004813 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1306400004814 active site 1306400004815 HIGH motif; other site 1306400004816 dimer interface [polypeptide binding]; other site 1306400004817 KMSKS motif; other site 1306400004818 S4 RNA-binding domain; Region: S4; smart00363 1306400004819 RNA binding surface [nucleotide binding]; other site 1306400004820 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400004821 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1306400004822 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1306400004823 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1306400004824 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1306400004825 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1306400004826 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1306400004827 RNA binding surface [nucleotide binding]; other site 1306400004828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400004829 S-adenosylmethionine binding site [chemical binding]; other site 1306400004830 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1306400004831 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1306400004832 DNA repair protein RecN; Region: recN; TIGR00634 1306400004833 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1306400004834 Walker A/P-loop; other site 1306400004835 ATP binding site [chemical binding]; other site 1306400004836 Q-loop/lid; other site 1306400004837 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1306400004838 ABC transporter signature motif; other site 1306400004839 Walker B; other site 1306400004840 D-loop; other site 1306400004841 H-loop/switch region; other site 1306400004842 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1306400004843 Thiamine pyrophosphokinase; Region: TPK; cl08415 1306400004844 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1306400004845 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1306400004846 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1306400004847 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1306400004848 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1306400004849 active site 1306400004850 putative oxyanion hole; other site 1306400004851 catalytic triad [active] 1306400004852 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1306400004853 dimer interface [polypeptide binding]; other site 1306400004854 ADP-ribose binding site [chemical binding]; other site 1306400004855 active site 1306400004856 nudix motif; other site 1306400004857 metal binding site [ion binding]; metal-binding site 1306400004858 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1306400004859 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306400004860 active site 1306400004861 DNA binding site [nucleotide binding] 1306400004862 Int/Topo IB signature motif; other site 1306400004863 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400004864 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400004865 active site 1306400004866 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1306400004867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400004868 S-adenosylmethionine binding site [chemical binding]; other site 1306400004869 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1306400004870 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400004871 PPE family; Region: PPE; pfam00823 1306400004872 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400004873 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400004874 PPE family; Region: PPE; pfam00823 1306400004875 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400004876 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1306400004877 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1306400004878 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1306400004879 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1306400004880 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306400004881 P-loop; other site 1306400004882 Magnesium ion binding site [ion binding]; other site 1306400004883 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306400004884 Magnesium ion binding site [ion binding]; other site 1306400004885 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1306400004886 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1306400004887 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1306400004888 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1306400004889 RNA binding surface [nucleotide binding]; other site 1306400004890 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1306400004891 active site 1306400004892 cytidylate kinase; Provisional; Region: cmk; PRK00023 1306400004893 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1306400004894 CMP-binding site; other site 1306400004895 The sites determining sugar specificity; other site 1306400004896 GTP-binding protein Der; Reviewed; Region: PRK03003 1306400004897 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1306400004898 GTP/Mg2+ binding site [chemical binding]; other site 1306400004899 Switch I region; other site 1306400004900 G2 box; other site 1306400004901 Switch II region; other site 1306400004902 G3 box; other site 1306400004903 G4 box; other site 1306400004904 G5 box; other site 1306400004905 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1306400004906 G1 box; other site 1306400004907 GTP/Mg2+ binding site [chemical binding]; other site 1306400004908 Switch I region; other site 1306400004909 G2 box; other site 1306400004910 G3 box; other site 1306400004911 Switch II region; other site 1306400004912 G4 box; other site 1306400004913 G5 box; other site 1306400004914 short chain dehydrogenase; Provisional; Region: PRK07060 1306400004915 classical (c) SDRs; Region: SDR_c; cd05233 1306400004916 NAD(P) binding site [chemical binding]; other site 1306400004917 active site 1306400004918 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1306400004919 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1306400004920 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1306400004921 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1306400004922 Cupin domain; Region: Cupin_2; pfam07883 1306400004923 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1306400004924 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1306400004925 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1306400004926 putative switch regulator; other site 1306400004927 non-specific DNA interactions [nucleotide binding]; other site 1306400004928 DNA binding site [nucleotide binding] 1306400004929 sequence specific DNA binding site [nucleotide binding]; other site 1306400004930 putative cAMP binding site [chemical binding]; other site 1306400004931 Bacterial transcriptional regulator; Region: IclR; pfam01614 1306400004932 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1306400004933 putative active site [active] 1306400004934 homotetrameric interface [polypeptide binding]; other site 1306400004935 metal binding site [ion binding]; metal-binding site 1306400004936 biotin carboxylase-like protein; Validated; Region: PRK06524 1306400004937 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306400004938 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400004939 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400004940 Predicted transcriptional regulators [Transcription]; Region: COG1733 1306400004941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400004942 dimerization interface [polypeptide binding]; other site 1306400004943 putative DNA binding site [nucleotide binding]; other site 1306400004944 putative Zn2+ binding site [ion binding]; other site 1306400004945 Predicted transcriptional regulators [Transcription]; Region: COG1733 1306400004946 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400004947 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400004948 Berberine and berberine like; Region: BBE; pfam08031 1306400004949 TIGR03086 family protein; Region: TIGR03086 1306400004950 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400004951 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400004952 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400004953 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400004954 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1306400004955 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1306400004956 NAD(P) binding site [chemical binding]; other site 1306400004957 catalytic residues [active] 1306400004958 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1306400004959 putative catalytic residue [active] 1306400004960 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1306400004961 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1306400004962 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1306400004963 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1306400004964 gating phenylalanine in ion channel; other site 1306400004965 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1306400004966 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1306400004967 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306400004968 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1306400004969 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1306400004970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400004971 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1306400004972 putative substrate translocation pore; other site 1306400004973 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1306400004974 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1306400004975 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1306400004976 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1306400004977 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1306400004978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1306400004979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1306400004980 putative active site [active] 1306400004981 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1306400004982 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400004983 active site 1306400004984 ATP binding site [chemical binding]; other site 1306400004985 substrate binding site [chemical binding]; other site 1306400004986 activation loop (A-loop); other site 1306400004987 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1306400004988 Thioredoxin; Region: Thioredoxin_4; cl17273 1306400004989 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1306400004990 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1306400004991 active site 1306400004992 metal binding site [ion binding]; metal-binding site 1306400004993 nudix motif; other site 1306400004994 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400004995 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400004996 active site 1306400004997 ATP binding site [chemical binding]; other site 1306400004998 substrate binding site [chemical binding]; other site 1306400004999 activation loop (A-loop); other site 1306400005000 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306400005001 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306400005002 phosphopeptide binding site; other site 1306400005003 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306400005004 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306400005005 phosphopeptide binding site; other site 1306400005006 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1306400005007 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1306400005008 Walker A/P-loop; other site 1306400005009 ATP binding site [chemical binding]; other site 1306400005010 Q-loop/lid; other site 1306400005011 ABC transporter signature motif; other site 1306400005012 Walker B; other site 1306400005013 D-loop; other site 1306400005014 H-loop/switch region; other site 1306400005015 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1306400005016 acyl-CoA synthetase; Provisional; Region: PRK13388 1306400005017 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400005018 acyl-activating enzyme (AAE) consensus motif; other site 1306400005019 AMP binding site [chemical binding]; other site 1306400005020 active site 1306400005021 CoA binding site [chemical binding]; other site 1306400005022 hypothetical protein; Provisional; Region: PRK06185 1306400005023 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306400005024 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1306400005025 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1306400005026 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005027 PPE family; Region: PPE; pfam00823 1306400005028 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400005029 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400005030 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1306400005031 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306400005032 putative transposase OrfB; Reviewed; Region: PHA02517 1306400005033 HTH-like domain; Region: HTH_21; pfam13276 1306400005034 Integrase core domain; Region: rve; pfam00665 1306400005035 Integrase core domain; Region: rve_3; pfam13683 1306400005036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400005037 Transposase; Region: HTH_Tnp_1; cl17663 1306400005038 Cutinase; Region: Cutinase; pfam01083 1306400005039 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400005040 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400005041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400005042 Transposase; Region: HTH_Tnp_1; cl17663 1306400005043 putative transposase OrfB; Reviewed; Region: PHA02517 1306400005044 HTH-like domain; Region: HTH_21; pfam13276 1306400005045 Integrase core domain; Region: rve; pfam00665 1306400005046 Integrase core domain; Region: rve_3; pfam13683 1306400005047 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400005048 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400005049 active site 1306400005050 Integrase core domain; Region: rve; pfam00665 1306400005051 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1306400005052 putative homotetramer interface [polypeptide binding]; other site 1306400005053 putative homodimer interface [polypeptide binding]; other site 1306400005054 putative allosteric switch controlling residues; other site 1306400005055 putative metal binding site [ion binding]; other site 1306400005056 putative homodimer-homodimer interface [polypeptide binding]; other site 1306400005057 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1306400005058 PE family; Region: PE; pfam00934 1306400005059 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1306400005060 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1306400005061 dimer interface [polypeptide binding]; other site 1306400005062 active site 1306400005063 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1306400005064 substrate binding site [chemical binding]; other site 1306400005065 catalytic residue [active] 1306400005066 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1306400005067 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1306400005068 metal binding site [ion binding]; metal-binding site 1306400005069 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1306400005070 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400005071 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1306400005072 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1306400005073 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1306400005074 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1306400005075 Bacterial transcriptional regulator; Region: IclR; pfam01614 1306400005076 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400005077 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400005078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400005079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400005080 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400005081 Cytochrome P450; Region: p450; cl12078 1306400005082 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1306400005083 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1306400005084 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1306400005085 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1306400005086 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306400005087 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400005088 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306400005089 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400005090 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400005091 Cytochrome P450; Region: p450; cl12078 1306400005092 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1306400005093 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005094 PPE family; Region: PPE; pfam00823 1306400005095 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400005096 PE family; Region: PE; pfam00934 1306400005097 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005098 PPE family; Region: PPE; pfam00823 1306400005099 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400005100 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005101 PPE family; Region: PPE; pfam00823 1306400005102 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400005103 PE family; Region: PE; pfam00934 1306400005104 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306400005105 EspG family; Region: ESX-1_EspG; pfam14011 1306400005106 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306400005107 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306400005108 catalytic residues [active] 1306400005109 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1306400005110 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1306400005111 active site 1306400005112 catalytic residues [active] 1306400005113 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1306400005114 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1306400005115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400005116 Walker A motif; other site 1306400005117 ATP binding site [chemical binding]; other site 1306400005118 Walker B motif; other site 1306400005119 arginine finger; other site 1306400005120 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005121 PPE family; Region: PPE; pfam00823 1306400005122 PE-PPE domain; Region: PE-PPE; pfam08237 1306400005123 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005124 PPE family; Region: PPE; pfam00823 1306400005125 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005126 PPE family; Region: PPE; pfam00823 1306400005127 PE family; Region: PE; pfam00934 1306400005128 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400005129 PE family; Region: PE; pfam00934 1306400005130 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005131 PPE family; Region: PPE; pfam00823 1306400005132 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005133 PPE family; Region: PPE; pfam00823 1306400005134 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005135 PPE family; Region: PPE; pfam00823 1306400005136 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400005137 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400005138 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1306400005139 MgtC family; Region: MgtC; pfam02308 1306400005140 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1306400005141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400005142 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1306400005143 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1306400005144 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1306400005145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400005146 hypothetical protein; Validated; Region: PRK07121 1306400005147 PE family; Region: PE; pfam00934 1306400005148 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1306400005149 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1306400005150 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1306400005151 hypothetical protein; Provisional; Region: PRK05858 1306400005152 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306400005153 PYR/PP interface [polypeptide binding]; other site 1306400005154 dimer interface [polypeptide binding]; other site 1306400005155 TPP binding site [chemical binding]; other site 1306400005156 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306400005157 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1306400005158 TPP-binding site; other site 1306400005159 dimer interface [polypeptide binding]; other site 1306400005160 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1306400005161 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1306400005162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1306400005163 nucleotide binding region [chemical binding]; other site 1306400005164 ATP-binding site [chemical binding]; other site 1306400005165 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1306400005166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1306400005167 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1306400005168 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1306400005169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1306400005170 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1306400005171 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1306400005172 lipoyl attachment site [posttranslational modification]; other site 1306400005173 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306400005174 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306400005175 phosphopeptide binding site; other site 1306400005176 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1306400005177 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1306400005178 DNA binding residues [nucleotide binding] 1306400005179 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1306400005180 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1306400005181 DNA binding residues [nucleotide binding] 1306400005182 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1306400005183 putative dimer interface [polypeptide binding]; other site 1306400005184 glycine dehydrogenase; Provisional; Region: PRK05367 1306400005185 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1306400005186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400005187 tetramer interface [polypeptide binding]; other site 1306400005188 catalytic residue [active] 1306400005189 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1306400005190 tetramer interface [polypeptide binding]; other site 1306400005191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400005192 catalytic residue [active] 1306400005193 haloalkane dehalogenase; Provisional; Region: PRK03204 1306400005194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306400005195 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1306400005196 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1306400005197 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1306400005198 metal ion-dependent adhesion site (MIDAS); other site 1306400005199 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1306400005200 active site 1306400005201 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306400005202 putative active site [active] 1306400005203 Domain of unknown function DUF21; Region: DUF21; pfam01595 1306400005204 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1306400005205 FOG: CBS domain [General function prediction only]; Region: COG0517 1306400005206 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1306400005207 Domain of unknown function DUF21; Region: DUF21; pfam01595 1306400005208 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1306400005209 Transporter associated domain; Region: CorC_HlyC; smart01091 1306400005210 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1306400005211 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306400005212 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1306400005213 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1306400005214 active site 1306400005215 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1306400005216 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1306400005217 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1306400005218 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1306400005219 Predicted transcriptional regulator [Transcription]; Region: COG3682 1306400005220 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1306400005221 CoenzymeA binding site [chemical binding]; other site 1306400005222 subunit interaction site [polypeptide binding]; other site 1306400005223 PHB binding site; other site 1306400005224 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1306400005225 alpha-gamma subunit interface [polypeptide binding]; other site 1306400005226 beta-gamma subunit interface [polypeptide binding]; other site 1306400005227 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1306400005228 gamma-beta subunit interface [polypeptide binding]; other site 1306400005229 alpha-beta subunit interface [polypeptide binding]; other site 1306400005230 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1306400005231 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1306400005232 subunit interactions [polypeptide binding]; other site 1306400005233 active site 1306400005234 flap region; other site 1306400005235 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1306400005236 UreF; Region: UreF; pfam01730 1306400005237 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1306400005238 UreD urease accessory protein; Region: UreD; cl00530 1306400005239 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1306400005240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400005241 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1306400005242 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400005243 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400005244 classical (c) SDRs; Region: SDR_c; cd05233 1306400005245 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1306400005246 NAD(P) binding site [chemical binding]; other site 1306400005247 active site 1306400005248 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1306400005249 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1306400005250 sulfate transport protein; Provisional; Region: cysT; CHL00187 1306400005251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400005252 dimer interface [polypeptide binding]; other site 1306400005253 conserved gate region; other site 1306400005254 putative PBP binding loops; other site 1306400005255 ABC-ATPase subunit interface; other site 1306400005256 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1306400005257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400005258 Walker A/P-loop; other site 1306400005259 ATP binding site [chemical binding]; other site 1306400005260 Q-loop/lid; other site 1306400005261 ABC transporter signature motif; other site 1306400005262 Walker B; other site 1306400005263 D-loop; other site 1306400005264 H-loop/switch region; other site 1306400005265 TOBE domain; Region: TOBE; pfam03459 1306400005266 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1306400005267 Predicted membrane protein [Function unknown]; Region: COG2261 1306400005268 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1306400005269 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1306400005270 putative NAD(P) binding site [chemical binding]; other site 1306400005271 putative substrate binding site [chemical binding]; other site 1306400005272 catalytic Zn binding site [ion binding]; other site 1306400005273 structural Zn binding site [ion binding]; other site 1306400005274 CAAX protease self-immunity; Region: Abi; pfam02517 1306400005275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1306400005276 MOSC domain; Region: MOSC; pfam03473 1306400005277 short chain dehydrogenase; Provisional; Region: PRK07825 1306400005278 classical (c) SDRs; Region: SDR_c; cd05233 1306400005279 NAD(P) binding site [chemical binding]; other site 1306400005280 active site 1306400005281 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306400005282 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306400005283 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306400005284 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306400005285 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1306400005286 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306400005287 active site 1306400005288 hypothetical protein; Provisional; Region: PRK12320 1306400005289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400005290 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1306400005291 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400005292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400005293 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306400005294 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1306400005295 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1306400005296 active site 1306400005297 substrate binding site [chemical binding]; other site 1306400005298 FMN binding site [chemical binding]; other site 1306400005299 putative catalytic residues [active] 1306400005300 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1306400005301 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1306400005302 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1306400005303 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1306400005304 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1306400005305 heme binding site [chemical binding]; other site 1306400005306 ferroxidase pore; other site 1306400005307 ferroxidase diiron center [ion binding]; other site 1306400005308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400005309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306400005310 putative substrate translocation pore; other site 1306400005311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400005312 putative substrate translocation pore; other site 1306400005313 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 1306400005314 23S rRNA interface [nucleotide binding]; other site 1306400005315 L3 interface [polypeptide binding]; other site 1306400005316 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306400005317 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1306400005318 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1306400005319 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1306400005320 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400005321 Cytochrome P450; Region: p450; cl12078 1306400005322 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1306400005323 short chain dehydrogenase; Provisional; Region: PRK08267 1306400005324 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1306400005325 putative NAD(P) binding site [chemical binding]; other site 1306400005326 active site 1306400005327 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1306400005328 hydrophobic ligand binding site; other site 1306400005329 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306400005330 chorismate mutase; Provisional; Region: PRK09269 1306400005331 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1306400005332 Putative esterase; Region: Esterase; pfam00756 1306400005333 potential frameshift: common BLAST hit: gi|433634937|ref|YP_007268564.1| Putative S-adenosyl-L-methionine-dependent methyltransferase 1306400005334 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1306400005335 Nitronate monooxygenase; Region: NMO; pfam03060 1306400005336 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306400005337 FMN binding site [chemical binding]; other site 1306400005338 substrate binding site [chemical binding]; other site 1306400005339 putative catalytic residue [active] 1306400005340 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 1306400005341 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1306400005342 catalytic Zn binding site [ion binding]; other site 1306400005343 NAD(P) binding site [chemical binding]; other site 1306400005344 structural Zn binding site [ion binding]; other site 1306400005345 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400005346 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400005347 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1306400005348 putative active site [active] 1306400005349 dimerization interface [polypeptide binding]; other site 1306400005350 putative tRNAtyr binding site [nucleotide binding]; other site 1306400005351 Domain of unknown function DUF77; Region: DUF77; pfam01910 1306400005352 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1306400005353 putative ADP-ribose binding site [chemical binding]; other site 1306400005354 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400005355 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400005356 cyclase homology domain; Region: CHD; cd07302 1306400005357 nucleotidyl binding site; other site 1306400005358 metal binding site [ion binding]; metal-binding site 1306400005359 dimer interface [polypeptide binding]; other site 1306400005360 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1306400005361 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1306400005362 putative MPT binding site; other site 1306400005363 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1306400005364 putative sialic acid transporter; Region: 2A0112; TIGR00891 1306400005365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400005366 putative substrate translocation pore; other site 1306400005367 Predicted membrane protein [Function unknown]; Region: COG1950 1306400005368 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306400005369 anti sigma factor interaction site; other site 1306400005370 regulatory phosphorylation site [posttranslational modification]; other site 1306400005371 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1306400005372 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1306400005373 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1306400005374 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1306400005375 dimer interface [polypeptide binding]; other site 1306400005376 active site 1306400005377 heme binding site [chemical binding]; other site 1306400005378 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1306400005379 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1306400005380 metal binding site 2 [ion binding]; metal-binding site 1306400005381 putative DNA binding helix; other site 1306400005382 metal binding site 1 [ion binding]; metal-binding site 1306400005383 dimer interface [polypeptide binding]; other site 1306400005384 structural Zn2+ binding site [ion binding]; other site 1306400005385 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1306400005386 substrate binding site [chemical binding]; other site 1306400005387 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1306400005388 substrate binding site [chemical binding]; other site 1306400005389 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1306400005390 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306400005391 NAD(P) binding site [chemical binding]; other site 1306400005392 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306400005393 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1306400005394 tetramer interface [polypeptide binding]; other site 1306400005395 active site 1306400005396 Mg2+/Mn2+ binding site [ion binding]; other site 1306400005397 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 1306400005398 potential frameshift: common BLAST hit: gi|148661725|ref|YP_001283248.1| PPE family protein 1306400005399 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005400 PPE family; Region: PPE; pfam00823 1306400005401 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400005402 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400005403 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1306400005404 putative hydrophobic ligand binding site [chemical binding]; other site 1306400005405 protein interface [polypeptide binding]; other site 1306400005406 gate; other site 1306400005407 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400005408 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1306400005409 putative acyl-acceptor binding pocket; other site 1306400005410 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1306400005411 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400005412 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400005413 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400005414 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400005415 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1306400005416 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400005417 acyl-activating enzyme (AAE) consensus motif; other site 1306400005418 active site 1306400005419 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1306400005420 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1306400005421 short chain dehydrogenase; Provisional; Region: PRK05867 1306400005422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400005423 NAD(P) binding site [chemical binding]; other site 1306400005424 active site 1306400005425 TIGR03085 family protein; Region: TIGR03085 1306400005426 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1306400005427 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1306400005428 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1306400005429 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1306400005430 conserved cys residue [active] 1306400005431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306400005432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306400005433 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1306400005434 dimer interface [polypeptide binding]; other site 1306400005435 catalytic triad [active] 1306400005436 peroxidatic and resolving cysteines [active] 1306400005437 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400005438 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306400005439 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1306400005440 active site 1306400005441 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400005442 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1306400005443 FAD binding site [chemical binding]; other site 1306400005444 substrate binding site [chemical binding]; other site 1306400005445 catalytic base [active] 1306400005446 enoyl-CoA hydratase; Provisional; Region: PRK08290 1306400005447 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400005448 substrate binding site [chemical binding]; other site 1306400005449 oxyanion hole (OAH) forming residues; other site 1306400005450 trimer interface [polypeptide binding]; other site 1306400005451 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400005452 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1306400005453 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1306400005454 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306400005455 catalytic loop [active] 1306400005456 iron binding site [ion binding]; other site 1306400005457 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1306400005458 FAD binding pocket [chemical binding]; other site 1306400005459 FAD binding motif [chemical binding]; other site 1306400005460 phosphate binding motif [ion binding]; other site 1306400005461 beta-alpha-beta structure motif; other site 1306400005462 NAD binding pocket [chemical binding]; other site 1306400005463 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400005464 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306400005465 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1306400005466 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1306400005467 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1306400005468 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1306400005469 dimerization interface [polypeptide binding]; other site 1306400005470 active site 1306400005471 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1306400005472 putative NAD(P) binding site [chemical binding]; other site 1306400005473 active site 1306400005474 homodimer interface [polypeptide binding]; other site 1306400005475 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306400005476 SEC-C motif; Region: SEC-C; pfam02810 1306400005477 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400005478 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400005479 active site 1306400005480 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1306400005481 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1306400005482 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1306400005483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400005484 non-specific DNA binding site [nucleotide binding]; other site 1306400005485 salt bridge; other site 1306400005486 sequence-specific DNA binding site [nucleotide binding]; other site 1306400005487 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1306400005488 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1306400005489 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1306400005490 putative active site [active] 1306400005491 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400005492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400005493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400005494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400005495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400005496 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306400005497 Permease; Region: Permease; pfam02405 1306400005498 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306400005499 Permease; Region: Permease; pfam02405 1306400005500 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400005501 mce related protein; Region: MCE; pfam02470 1306400005502 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306400005503 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400005504 mce related protein; Region: MCE; pfam02470 1306400005505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400005506 mce related protein; Region: MCE; pfam02470 1306400005507 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400005508 mce related protein; Region: MCE; pfam02470 1306400005509 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400005510 mce related protein; Region: MCE; pfam02470 1306400005511 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400005512 mce related protein; Region: MCE; pfam02470 1306400005513 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400005514 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1306400005515 YacP-like NYN domain; Region: NYN_YacP; cl01491 1306400005516 Peptidase family M48; Region: Peptidase_M48; pfam01435 1306400005517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400005518 S-adenosylmethionine binding site [chemical binding]; other site 1306400005519 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1306400005520 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1306400005521 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1306400005522 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1306400005523 dimer interface [polypeptide binding]; other site 1306400005524 putative radical transfer pathway; other site 1306400005525 diiron center [ion binding]; other site 1306400005526 tyrosyl radical; other site 1306400005527 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1306400005528 putative active site [active] 1306400005529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1306400005530 PE family; Region: PE; pfam00934 1306400005531 Cutinase; Region: Cutinase; pfam01083 1306400005532 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1306400005533 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1306400005534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306400005535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1306400005536 dimerization interface [polypeptide binding]; other site 1306400005537 Lysine efflux permease [General function prediction only]; Region: COG1279 1306400005538 Cellulose binding domain; Region: CBM_2; pfam00553 1306400005539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400005540 S-adenosylmethionine binding site [chemical binding]; other site 1306400005541 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1306400005542 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1306400005543 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1306400005544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400005545 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306400005546 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400005547 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1306400005548 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400005549 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1306400005550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400005551 dimerization interface [polypeptide binding]; other site 1306400005552 putative DNA binding site [nucleotide binding]; other site 1306400005553 putative Zn2+ binding site [ion binding]; other site 1306400005554 Hemerythrin-like domain; Region: Hr-like; cd12108 1306400005555 Fe binding site [ion binding]; other site 1306400005556 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400005557 Ligand Binding Site [chemical binding]; other site 1306400005558 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400005559 Ligand Binding Site [chemical binding]; other site 1306400005560 potential frameshift: common BLAST hit: gi|397673873|ref|YP_006515408.1| HAD ATPase, P-type, family IC 1306400005561 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1306400005562 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306400005563 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1306400005564 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1306400005565 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1306400005566 tetramer interface [polypeptide binding]; other site 1306400005567 active site 1306400005568 Mg2+/Mn2+ binding site [ion binding]; other site 1306400005569 potential frameshift: common BLAST hit: gi|385994971|ref|YP_005913269.1| integral membrane protein 1306400005570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306400005571 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1306400005572 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1306400005573 homotetramer interface [polypeptide binding]; other site 1306400005574 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1306400005575 NAD binding site [chemical binding]; other site 1306400005576 homodimer interface [polypeptide binding]; other site 1306400005577 active site 1306400005578 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400005579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400005580 S-adenosylmethionine binding site [chemical binding]; other site 1306400005581 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1306400005582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1306400005583 Predicted kinase [General function prediction only]; Region: COG0645 1306400005584 AAA domain; Region: AAA_17; pfam13207 1306400005585 Universal stress protein family; Region: Usp; pfam00582 1306400005586 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400005587 Ligand Binding Site [chemical binding]; other site 1306400005588 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1306400005589 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1306400005590 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1306400005591 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1306400005592 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1306400005593 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1306400005594 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1306400005595 Ferredoxin [Energy production and conversion]; Region: COG1146 1306400005596 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1306400005597 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1306400005598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400005599 Walker A motif; other site 1306400005600 ATP binding site [chemical binding]; other site 1306400005601 Walker B motif; other site 1306400005602 arginine finger; other site 1306400005603 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306400005604 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306400005605 putative active site [active] 1306400005606 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1306400005607 MarR family; Region: MarR_2; pfam12802 1306400005608 Phage envelope protein [General function prediction only]; Region: COG5562 1306400005609 Predicted helicase [General function prediction only]; Region: COG4889 1306400005610 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306400005611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306400005612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306400005613 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1306400005614 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400005615 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400005616 active site 1306400005617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306400005618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400005619 non-specific DNA binding site [nucleotide binding]; other site 1306400005620 salt bridge; other site 1306400005621 sequence-specific DNA binding site [nucleotide binding]; other site 1306400005622 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1306400005623 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1306400005624 Predicted helicase [General function prediction only]; Region: COG4889 1306400005625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400005626 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1306400005627 non-specific DNA binding site [nucleotide binding]; other site 1306400005628 salt bridge; other site 1306400005629 sequence-specific DNA binding site [nucleotide binding]; other site 1306400005630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1306400005631 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1306400005632 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1306400005633 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1306400005634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306400005635 ATP binding site [chemical binding]; other site 1306400005636 putative Mg++ binding site [ion binding]; other site 1306400005637 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1306400005638 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1306400005639 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400005640 Ligand Binding Site [chemical binding]; other site 1306400005641 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400005642 Ligand Binding Site [chemical binding]; other site 1306400005643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1306400005644 Histidine kinase; Region: HisKA_3; pfam07730 1306400005645 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1306400005646 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1306400005647 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400005648 Ligand Binding Site [chemical binding]; other site 1306400005649 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1306400005650 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1306400005651 putative substrate binding site [chemical binding]; other site 1306400005652 putative ATP binding site [chemical binding]; other site 1306400005653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400005654 active site 1306400005655 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1306400005656 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1306400005657 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1306400005658 putative dimer interface [polypeptide binding]; other site 1306400005659 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306400005660 dimer interface [polypeptide binding]; other site 1306400005661 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1306400005662 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400005663 putative DNA binding site [nucleotide binding]; other site 1306400005664 dimerization interface [polypeptide binding]; other site 1306400005665 putative Zn2+ binding site [ion binding]; other site 1306400005666 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1306400005667 putative hydrophobic ligand binding site [chemical binding]; other site 1306400005668 CLM binding site; other site 1306400005669 L1 loop; other site 1306400005670 DNA binding site [nucleotide binding] 1306400005671 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306400005672 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1306400005673 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1306400005674 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306400005675 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1306400005676 nucleophile elbow; other site 1306400005677 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1306400005678 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1306400005679 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1306400005680 Walker A/P-loop; other site 1306400005681 ATP binding site [chemical binding]; other site 1306400005682 Q-loop/lid; other site 1306400005683 ABC transporter signature motif; other site 1306400005684 Walker B; other site 1306400005685 D-loop; other site 1306400005686 H-loop/switch region; other site 1306400005687 TOBE domain; Region: TOBE_2; pfam08402 1306400005688 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1306400005689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400005690 dimer interface [polypeptide binding]; other site 1306400005691 conserved gate region; other site 1306400005692 putative PBP binding loops; other site 1306400005693 ABC-ATPase subunit interface; other site 1306400005694 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1306400005695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400005696 dimer interface [polypeptide binding]; other site 1306400005697 conserved gate region; other site 1306400005698 putative PBP binding loops; other site 1306400005699 ABC-ATPase subunit interface; other site 1306400005700 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1306400005701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1306400005702 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1306400005703 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1306400005704 Isochorismatase family; Region: Isochorismatase; pfam00857 1306400005705 catalytic triad [active] 1306400005706 metal binding site [ion binding]; metal-binding site 1306400005707 conserved cis-peptide bond; other site 1306400005708 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1306400005709 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1306400005710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400005711 substrate binding pocket [chemical binding]; other site 1306400005712 catalytic triad [active] 1306400005713 hypothetical protein; Provisional; Region: PRK05865 1306400005714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400005715 NAD(P) binding site [chemical binding]; other site 1306400005716 active site 1306400005717 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1306400005718 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400005719 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400005720 active site 1306400005721 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400005722 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400005723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400005724 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400005725 Enoylreductase; Region: PKS_ER; smart00829 1306400005726 NAD(P) binding site [chemical binding]; other site 1306400005727 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1306400005728 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306400005729 putative NADP binding site [chemical binding]; other site 1306400005730 active site 1306400005731 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400005732 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400005733 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400005734 active site 1306400005735 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400005736 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400005737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400005738 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400005739 Enoylreductase; Region: PKS_ER; smart00829 1306400005740 NAD(P) binding site [chemical binding]; other site 1306400005741 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1306400005742 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306400005743 putative NADP binding site [chemical binding]; other site 1306400005744 active site 1306400005745 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400005746 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1306400005747 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1306400005748 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1306400005749 putative active site [active] 1306400005750 catalytic triad [active] 1306400005751 putative dimer interface [polypeptide binding]; other site 1306400005752 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1306400005753 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1306400005754 Ligand binding site; other site 1306400005755 Putative Catalytic site; other site 1306400005756 DXD motif; other site 1306400005757 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1306400005758 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1306400005759 active site 1306400005760 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1306400005761 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1306400005762 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1306400005763 30S ribosomal protein S18; Provisional; Region: PRK13401 1306400005764 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1306400005765 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1306400005766 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1306400005767 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1306400005768 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1306400005769 intersubunit interface [polypeptide binding]; other site 1306400005770 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1306400005771 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1306400005772 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1306400005773 potential frameshift: common BLAST hit: gi|385995032|ref|YP_005913330.1| cobaltochelatase subunit CobN 1306400005774 PemK-like protein; Region: PemK; pfam02452 1306400005775 precorrin-3B synthase; Region: CobG; TIGR02435 1306400005776 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1306400005777 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1306400005778 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1306400005779 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1306400005780 active site 1306400005781 SAM binding site [chemical binding]; other site 1306400005782 homodimer interface [polypeptide binding]; other site 1306400005783 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1306400005784 active site 1306400005785 SAM binding site [chemical binding]; other site 1306400005786 homodimer interface [polypeptide binding]; other site 1306400005787 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306400005788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400005789 S-adenosylmethionine binding site [chemical binding]; other site 1306400005790 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1306400005791 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1306400005792 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1306400005793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400005794 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400005795 DNA binding residues [nucleotide binding] 1306400005796 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1306400005797 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1306400005798 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1306400005799 active site 1306400005800 SAM binding site [chemical binding]; other site 1306400005801 homodimer interface [polypeptide binding]; other site 1306400005802 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1306400005803 active site 1306400005804 putative homodimer interface [polypeptide binding]; other site 1306400005805 SAM binding site [chemical binding]; other site 1306400005806 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1306400005807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306400005808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400005809 NAD(P) binding site [chemical binding]; other site 1306400005810 active site 1306400005811 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1306400005812 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1306400005813 putative active site [active] 1306400005814 catalytic site [active] 1306400005815 putative metal binding site [ion binding]; other site 1306400005816 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1306400005817 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1306400005818 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1306400005819 putative transposase OrfB; Reviewed; Region: PHA02517 1306400005820 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400005821 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400005822 active site 1306400005823 ATP binding site [chemical binding]; other site 1306400005824 substrate binding site [chemical binding]; other site 1306400005825 activation loop (A-loop); other site 1306400005826 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306400005827 potential frameshift: common BLAST hit: gi|385995056|ref|YP_005913354.1| dipeptidase pepE 1306400005828 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1306400005829 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1306400005830 active site 1306400005831 metal binding site 1 [ion binding]; metal-binding site 1306400005832 putative 5' ssDNA interaction site; other site 1306400005833 metal binding site 3; metal-binding site 1306400005834 metal binding site 2 [ion binding]; metal-binding site 1306400005835 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1306400005836 putative DNA binding site [nucleotide binding]; other site 1306400005837 putative metal binding site [ion binding]; other site 1306400005838 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1306400005839 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1306400005840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306400005841 ATP binding site [chemical binding]; other site 1306400005842 putative Mg++ binding site [ion binding]; other site 1306400005843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400005844 nucleotide binding region [chemical binding]; other site 1306400005845 ATP-binding site [chemical binding]; other site 1306400005846 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1306400005847 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1306400005848 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1306400005849 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1306400005850 Predicted transcriptional regulator [Transcription]; Region: COG2378 1306400005851 WYL domain; Region: WYL; pfam13280 1306400005852 Predicted transcriptional regulator [Transcription]; Region: COG2378 1306400005853 WYL domain; Region: WYL; pfam13280 1306400005854 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1306400005855 PE family; Region: PE; pfam00934 1306400005856 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400005857 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400005858 active site 1306400005859 potential frameshift: common BLAST hit: gi|385991453|ref|YP_005909751.1| helicase helZ 1306400005860 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1306400005861 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306400005862 putative active site [active] 1306400005863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400005864 Transposase; Region: HTH_Tnp_1; cl17663 1306400005865 putative transposase OrfB; Reviewed; Region: PHA02517 1306400005866 HTH-like domain; Region: HTH_21; pfam13276 1306400005867 Integrase core domain; Region: rve; pfam00665 1306400005868 Integrase core domain; Region: rve_3; pfam13683 1306400005869 PE family; Region: PE; pfam00934 1306400005870 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005871 PPE family; Region: PPE; pfam00823 1306400005872 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1306400005873 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1306400005874 active site 1306400005875 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1306400005876 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1306400005877 active site 1306400005878 Pup-like protein; Region: Pup; pfam05639 1306400005879 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1306400005880 proteasome ATPase; Region: pup_AAA; TIGR03689 1306400005881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400005882 Walker A motif; other site 1306400005883 ATP binding site [chemical binding]; other site 1306400005884 Walker B motif; other site 1306400005885 arginine finger; other site 1306400005886 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1306400005887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1306400005888 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1306400005889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400005890 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1306400005891 Predicted membrane protein [Function unknown]; Region: COG3918 1306400005892 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1306400005893 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1306400005894 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1306400005895 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1306400005896 homodimer interface [polypeptide binding]; other site 1306400005897 putative metal binding site [ion binding]; other site 1306400005898 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400005899 PPE family; Region: PPE; pfam00823 1306400005900 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1306400005901 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1306400005902 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1306400005903 substrate binding pocket [chemical binding]; other site 1306400005904 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1306400005905 B12 binding site [chemical binding]; other site 1306400005906 cobalt ligand [ion binding]; other site 1306400005907 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1306400005908 PAC2 family; Region: PAC2; pfam09754 1306400005909 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1306400005910 short chain dehydrogenase; Provisional; Region: PRK05872 1306400005911 classical (c) SDRs; Region: SDR_c; cd05233 1306400005912 NAD(P) binding site [chemical binding]; other site 1306400005913 active site 1306400005914 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306400005915 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1306400005916 active site 1306400005917 HIGH motif; other site 1306400005918 nucleotide binding site [chemical binding]; other site 1306400005919 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306400005920 active site 1306400005921 KMSKS motif; other site 1306400005922 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1306400005923 putative tRNA binding surface [nucleotide binding]; other site 1306400005924 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1306400005925 active site 1306400005926 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400005927 conserved hypothetical protein; Region: TIGR03843 1306400005928 conserved hypothetical protein; Region: TIGR03847 1306400005929 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400005930 catalytic core [active] 1306400005931 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1306400005932 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1306400005933 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1306400005934 quinone interaction residues [chemical binding]; other site 1306400005935 active site 1306400005936 catalytic residues [active] 1306400005937 FMN binding site [chemical binding]; other site 1306400005938 substrate binding site [chemical binding]; other site 1306400005939 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1306400005940 substrate binding site [chemical binding]; other site 1306400005941 hypothetical protein; Provisional; Region: PRK07906 1306400005942 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1306400005943 putative metal binding site [ion binding]; other site 1306400005944 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1306400005945 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1306400005946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400005947 active site 1306400005948 DivIVA domain; Region: DivI1A_domain; TIGR03544 1306400005949 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1306400005950 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1306400005951 Predicted integral membrane protein [Function unknown]; Region: COG0762 1306400005952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1306400005953 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1306400005954 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1306400005955 catalytic residue [active] 1306400005956 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1306400005957 uncharacterized protein, YfiH family; Region: TIGR00726 1306400005958 cell division protein FtsZ; Validated; Region: PRK09330 1306400005959 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1306400005960 nucleotide binding site [chemical binding]; other site 1306400005961 SulA interaction site; other site 1306400005962 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1306400005963 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1306400005964 Cell division protein FtsQ; Region: FtsQ; pfam03799 1306400005965 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1306400005966 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1306400005967 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1306400005968 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306400005969 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1306400005970 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1306400005971 active site 1306400005972 cell division protein FtsW; Region: ftsW; TIGR02614 1306400005973 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1306400005974 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1306400005975 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306400005976 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1306400005977 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1306400005978 Mg++ binding site [ion binding]; other site 1306400005979 putative catalytic motif [active] 1306400005980 putative substrate binding site [chemical binding]; other site 1306400005981 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1306400005982 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1306400005983 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306400005984 potential frameshift: common BLAST hit: gi|449064216|ref|YP_007431299.1| UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1306400005985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400005986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400005987 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1306400005988 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400005989 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400005990 PE family; Region: PE; pfam00934 1306400005991 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1306400005992 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1306400005993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1306400005994 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1306400005995 MraW methylase family; Region: Methyltransf_5; pfam01795 1306400005996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1306400005997 MraZ protein; Region: MraZ; pfam02381 1306400005998 MraZ protein; Region: MraZ; pfam02381 1306400005999 putative transposase OrfB; Reviewed; Region: PHA02517 1306400006000 HTH-like domain; Region: HTH_21; pfam13276 1306400006001 Integrase core domain; Region: rve; pfam00665 1306400006002 Integrase core domain; Region: rve_3; pfam13683 1306400006003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400006004 Transposase; Region: HTH_Tnp_1; cl17663 1306400006005 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1306400006006 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1306400006007 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306400006008 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306400006009 substrate binding pocket [chemical binding]; other site 1306400006010 chain length determination region; other site 1306400006011 substrate-Mg2+ binding site; other site 1306400006012 catalytic residues [active] 1306400006013 aspartate-rich region 1; other site 1306400006014 active site lid residues [active] 1306400006015 aspartate-rich region 2; other site 1306400006016 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1306400006017 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400006018 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400006019 active site 1306400006020 ATP binding site [chemical binding]; other site 1306400006021 substrate binding site [chemical binding]; other site 1306400006022 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1306400006023 substrate binding site [chemical binding]; other site 1306400006024 activation loop (A-loop); other site 1306400006025 activation loop (A-loop); other site 1306400006026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306400006027 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1306400006028 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1306400006029 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1306400006030 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400006031 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306400006032 putative acyl-acceptor binding pocket; other site 1306400006033 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1306400006034 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1306400006035 DTAP/Switch II; other site 1306400006036 Switch I; other site 1306400006037 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1306400006038 putative hydrophobic ligand binding site [chemical binding]; other site 1306400006039 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1306400006040 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1306400006041 acyl-activating enzyme (AAE) consensus motif; other site 1306400006042 putative AMP binding site [chemical binding]; other site 1306400006043 putative active site [active] 1306400006044 putative CoA binding site [chemical binding]; other site 1306400006045 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306400006046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306400006047 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1306400006048 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1306400006049 NlpC/P60 family; Region: NLPC_P60; pfam00877 1306400006050 hypothetical protein; Validated; Region: PRK07883 1306400006051 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1306400006052 active site 1306400006053 catalytic site [active] 1306400006054 substrate binding site [chemical binding]; other site 1306400006055 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1306400006056 GIY-YIG motif/motif A; other site 1306400006057 active site 1306400006058 catalytic site [active] 1306400006059 putative DNA binding site [nucleotide binding]; other site 1306400006060 metal binding site [ion binding]; metal-binding site 1306400006061 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1306400006062 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1306400006063 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1306400006064 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1306400006065 Subunit I/III interface [polypeptide binding]; other site 1306400006066 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1306400006067 Cytochrome c; Region: Cytochrom_C; pfam00034 1306400006068 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1306400006069 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1306400006070 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1306400006071 iron-sulfur cluster [ion binding]; other site 1306400006072 [2Fe-2S] cluster binding site [ion binding]; other site 1306400006073 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1306400006074 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1306400006075 heme bH binding site [chemical binding]; other site 1306400006076 intrachain domain interface; other site 1306400006077 heme bL binding site [chemical binding]; other site 1306400006078 interchain domain interface [polypeptide binding]; other site 1306400006079 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1306400006080 Qo binding site; other site 1306400006081 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1306400006082 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1306400006083 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1306400006084 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1306400006085 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1306400006086 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1306400006087 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1306400006088 dimer interface [polypeptide binding]; other site 1306400006089 active site 1306400006090 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1306400006091 Ligand Binding Site [chemical binding]; other site 1306400006092 Molecular Tunnel; other site 1306400006093 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1306400006094 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1306400006095 substrate binding site [chemical binding]; other site 1306400006096 ATP binding site [chemical binding]; other site 1306400006097 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1306400006098 Glycerate kinase family; Region: Gly_kinase; pfam02595 1306400006099 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1306400006100 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1306400006101 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1306400006102 putative dimer interface [polypeptide binding]; other site 1306400006103 active site pocket [active] 1306400006104 putative cataytic base [active] 1306400006105 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1306400006106 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1306400006107 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1306400006108 homodimer interface [polypeptide binding]; other site 1306400006109 substrate-cofactor binding pocket; other site 1306400006110 catalytic residue [active] 1306400006111 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1306400006112 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1306400006113 cyclase homology domain; Region: CHD; cd07302 1306400006114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400006115 nucleotidyl binding site; other site 1306400006116 metal binding site [ion binding]; metal-binding site 1306400006117 dimer interface [polypeptide binding]; other site 1306400006118 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1306400006119 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1306400006120 interface (dimer of trimers) [polypeptide binding]; other site 1306400006121 Substrate-binding/catalytic site; other site 1306400006122 Zn-binding sites [ion binding]; other site 1306400006123 short chain dehydrogenase; Validated; Region: PRK05855 1306400006124 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306400006125 classical (c) SDRs; Region: SDR_c; cd05233 1306400006126 NAD(P) binding site [chemical binding]; other site 1306400006127 active site 1306400006128 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1306400006129 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1306400006130 E3 interaction surface; other site 1306400006131 lipoyl attachment site [posttranslational modification]; other site 1306400006132 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1306400006133 E3 interaction surface; other site 1306400006134 lipoyl attachment site [posttranslational modification]; other site 1306400006135 e3 binding domain; Region: E3_binding; pfam02817 1306400006136 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1306400006137 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1306400006138 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1306400006139 putative NAD(P) binding site [chemical binding]; other site 1306400006140 putative active site [active] 1306400006141 lipoate-protein ligase B; Provisional; Region: PRK14345 1306400006142 lipoyl synthase; Provisional; Region: PRK05481 1306400006143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400006144 FeS/SAM binding site; other site 1306400006145 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1306400006146 RDD family; Region: RDD; pfam06271 1306400006147 glutamine synthetase, type I; Region: GlnA; TIGR00653 1306400006148 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1306400006149 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1306400006150 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1306400006151 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1306400006152 metal binding triad; other site 1306400006153 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1306400006154 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1306400006155 metal binding triad; other site 1306400006156 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1306400006157 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1306400006158 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1306400006159 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1306400006160 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1306400006161 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306400006162 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1306400006163 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306400006164 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400006165 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1306400006166 oligomerization interface [polypeptide binding]; other site 1306400006167 active site 1306400006168 metal binding site [ion binding]; metal-binding site 1306400006169 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1306400006170 putative active site; other site 1306400006171 putative metal binding residues [ion binding]; other site 1306400006172 signature motif; other site 1306400006173 putative triphosphate binding site [ion binding]; other site 1306400006174 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1306400006175 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 1306400006176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1306400006177 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1306400006178 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1306400006179 RNA/DNA hybrid binding site [nucleotide binding]; other site 1306400006180 active site 1306400006181 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400006182 catalytic core [active] 1306400006183 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1306400006184 Putative zinc ribbon domain; Region: DUF164; pfam02591 1306400006185 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1306400006186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1306400006187 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1306400006188 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1306400006189 hypothetical protein; Provisional; Region: PRK07908 1306400006190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400006191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400006192 homodimer interface [polypeptide binding]; other site 1306400006193 catalytic residue [active] 1306400006194 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1306400006195 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 1306400006196 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1306400006197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400006198 active site 1306400006199 motif I; other site 1306400006200 motif II; other site 1306400006201 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1306400006202 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1306400006203 active site 1306400006204 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1306400006205 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1306400006206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1306400006207 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1306400006208 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1306400006209 dimer interface [polypeptide binding]; other site 1306400006210 catalytic triad [active] 1306400006211 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1306400006212 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1306400006213 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1306400006214 dimer interface [polypeptide binding]; other site 1306400006215 TPP-binding site [chemical binding]; other site 1306400006216 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306400006217 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1306400006218 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1306400006219 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306400006220 acyl carrier protein; Provisional; Region: acpP; PRK00982 1306400006221 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1306400006222 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1306400006223 dimer interface [polypeptide binding]; other site 1306400006224 active site 1306400006225 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1306400006226 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1306400006227 dimer interface [polypeptide binding]; other site 1306400006228 active site 1306400006229 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306400006230 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1306400006231 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306400006232 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306400006233 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1306400006234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400006235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400006236 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400006237 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400006238 diacylglycerol kinase; Reviewed; Region: PRK11914 1306400006239 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1306400006240 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1306400006241 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400006242 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400006243 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306400006244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400006245 S-adenosylmethionine binding site [chemical binding]; other site 1306400006246 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1306400006247 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1306400006248 NAD binding site [chemical binding]; other site 1306400006249 catalytic Zn binding site [ion binding]; other site 1306400006250 substrate binding site [chemical binding]; other site 1306400006251 structural Zn binding site [ion binding]; other site 1306400006252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306400006253 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1306400006254 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1306400006255 putative active site [active] 1306400006256 catalytic triad [active] 1306400006257 putative dimer interface [polypeptide binding]; other site 1306400006258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400006259 NAD(P) binding site [chemical binding]; other site 1306400006260 active site 1306400006261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400006262 active site 1306400006263 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306400006264 nucleotide binding site [chemical binding]; other site 1306400006265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306400006266 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400006267 Cytochrome P450; Region: p450; cl12078 1306400006268 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1306400006269 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400006270 Cytochrome P450; Region: p450; cl12078 1306400006271 Septum formation; Region: Septum_form; pfam13845 1306400006272 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1306400006273 Predicted membrane protein [Function unknown]; Region: COG2149 1306400006274 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1306400006275 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400006276 Cytochrome P450; Region: p450; cl12078 1306400006277 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1306400006278 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1306400006279 putative active site [active] 1306400006280 catalytic site [active] 1306400006281 putative metal binding site [ion binding]; other site 1306400006282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400006283 Transposase; Region: HTH_Tnp_1; cl17663 1306400006284 putative transposase OrfB; Reviewed; Region: PHA02517 1306400006285 HTH-like domain; Region: HTH_21; pfam13276 1306400006286 Integrase core domain; Region: rve; pfam00665 1306400006287 Integrase core domain; Region: rve_3; pfam13683 1306400006288 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1306400006289 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400006290 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1306400006291 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1306400006292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1306400006293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306400006294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1306400006295 dimerization interface [polypeptide binding]; other site 1306400006296 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400006297 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400006298 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306400006299 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400006300 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400006301 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1306400006302 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1306400006303 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1306400006304 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1306400006305 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1306400006306 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1306400006307 active site residue [active] 1306400006308 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1306400006309 active site residue [active] 1306400006310 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1306400006311 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1306400006312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400006313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400006314 homodimer interface [polypeptide binding]; other site 1306400006315 catalytic residue [active] 1306400006316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1306400006317 haloalkane dehalogenase; Provisional; Region: PRK00870 1306400006318 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1306400006319 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1306400006320 active site 1306400006321 catalytic tetrad [active] 1306400006322 heat shock protein 90; Provisional; Region: PRK05218 1306400006323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400006324 ATP binding site [chemical binding]; other site 1306400006325 Mg2+ binding site [ion binding]; other site 1306400006326 G-X-G motif; other site 1306400006327 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306400006328 Cutinase; Region: Cutinase; pfam01083 1306400006329 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1306400006330 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1306400006331 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1306400006332 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1306400006333 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1306400006334 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306400006335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1306400006336 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1306400006337 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306400006338 DNA binding site [nucleotide binding] 1306400006339 active site 1306400006340 Int/Topo IB signature motif; other site 1306400006341 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306400006342 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1306400006343 DNA binding residues [nucleotide binding] 1306400006344 Family description; Region: UvrD_C_2; pfam13538 1306400006345 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1306400006346 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1306400006347 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1306400006348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400006349 putative PBP binding loops; other site 1306400006350 ABC-ATPase subunit interface; other site 1306400006351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1306400006352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400006353 dimer interface [polypeptide binding]; other site 1306400006354 conserved gate region; other site 1306400006355 putative PBP binding loops; other site 1306400006356 ABC-ATPase subunit interface; other site 1306400006357 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1306400006358 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1306400006359 potential frameshift: common BLAST hit: gi|397674217|ref|YP_006515752.1| universal stress protein 1306400006360 potential frameshift: common BLAST hit: gi|449064386|ref|YP_007431469.1| cationic amino acid transport integral membrane protein RocE 1306400006361 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1306400006362 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306400006363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400006364 catalytic residue [active] 1306400006365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306400006366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400006367 Amidinotransferase; Region: Amidinotransf; pfam02274 1306400006368 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1306400006369 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1306400006370 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1306400006371 putative DNA binding site [nucleotide binding]; other site 1306400006372 putative Zn2+ binding site [ion binding]; other site 1306400006373 AsnC family; Region: AsnC_trans_reg; pfam01037 1306400006374 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1306400006375 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1306400006376 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1306400006377 Walker A/P-loop; other site 1306400006378 ATP binding site [chemical binding]; other site 1306400006379 Q-loop/lid; other site 1306400006380 ABC transporter signature motif; other site 1306400006381 Walker B; other site 1306400006382 D-loop; other site 1306400006383 H-loop/switch region; other site 1306400006384 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1306400006385 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1306400006386 Walker A/P-loop; other site 1306400006387 ATP binding site [chemical binding]; other site 1306400006388 Q-loop/lid; other site 1306400006389 ABC transporter signature motif; other site 1306400006390 Walker B; other site 1306400006391 D-loop; other site 1306400006392 H-loop/switch region; other site 1306400006393 MarR family; Region: MarR; pfam01047 1306400006394 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306400006395 PE family; Region: PE; pfam00934 1306400006396 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1306400006397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400006398 putative substrate translocation pore; other site 1306400006399 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1306400006400 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306400006401 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1306400006402 malate dehydrogenase; Provisional; Region: PRK13529 1306400006403 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1306400006404 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1306400006405 NAD(P) binding site [chemical binding]; other site 1306400006406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400006407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306400006408 putative substrate translocation pore; other site 1306400006409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400006410 putative substrate translocation pore; other site 1306400006411 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1306400006412 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1306400006413 dimer interface [polypeptide binding]; other site 1306400006414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400006415 catalytic residue [active] 1306400006416 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1306400006417 serine O-acetyltransferase; Region: cysE; TIGR01172 1306400006418 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1306400006419 trimer interface [polypeptide binding]; other site 1306400006420 active site 1306400006421 substrate binding site [chemical binding]; other site 1306400006422 CoA binding site [chemical binding]; other site 1306400006423 hypothetical protein; Provisional; Region: PRK14851 1306400006424 hypothetical protein; Validated; Region: PRK08223 1306400006425 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1306400006426 ATP binding site [chemical binding]; other site 1306400006427 substrate interface [chemical binding]; other site 1306400006428 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306400006429 PE family; Region: PE; pfam00934 1306400006430 DNA primase; Validated; Region: dnaG; PRK05667 1306400006431 CHC2 zinc finger; Region: zf-CHC2; cl17510 1306400006432 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1306400006433 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1306400006434 active site 1306400006435 metal binding site [ion binding]; metal-binding site 1306400006436 interdomain interaction site; other site 1306400006437 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1306400006438 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1306400006439 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1306400006440 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1306400006441 Zn2+ binding site [ion binding]; other site 1306400006442 Mg2+ binding site [ion binding]; other site 1306400006443 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1306400006444 Repair protein; Region: Repair_PSII; pfam04536 1306400006445 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306400006446 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1306400006447 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1306400006448 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306400006449 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1306400006450 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306400006451 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306400006452 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1306400006453 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306400006454 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400006455 PPE family; Region: PPE; pfam00823 1306400006456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400006457 Transposase; Region: HTH_Tnp_1; cl17663 1306400006458 putative transposase OrfB; Reviewed; Region: PHA02517 1306400006459 HTH-like domain; Region: HTH_21; pfam13276 1306400006460 Integrase core domain; Region: rve; pfam00665 1306400006461 Integrase core domain; Region: rve_3; pfam13683 1306400006462 PPE family; Region: PPE; pfam00823 1306400006463 PPE family; Region: PPE; pfam00823 1306400006464 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1306400006465 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306400006466 motif 1; other site 1306400006467 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1306400006468 active site 1306400006469 motif 2; other site 1306400006470 motif 3; other site 1306400006471 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1306400006472 anticodon binding site; other site 1306400006473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400006474 dimerization interface [polypeptide binding]; other site 1306400006475 putative DNA binding site [nucleotide binding]; other site 1306400006476 putative Zn2+ binding site [ion binding]; other site 1306400006477 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1306400006478 metal binding site 2 [ion binding]; metal-binding site 1306400006479 putative DNA binding helix; other site 1306400006480 metal binding site 1 [ion binding]; metal-binding site 1306400006481 dimer interface [polypeptide binding]; other site 1306400006482 structural Zn2+ binding site [ion binding]; other site 1306400006483 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1306400006484 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1306400006485 catalytic residue [active] 1306400006486 putative FPP diphosphate binding site; other site 1306400006487 putative FPP binding hydrophobic cleft; other site 1306400006488 dimer interface [polypeptide binding]; other site 1306400006489 putative IPP diphosphate binding site; other site 1306400006490 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1306400006491 Recombination protein O N terminal; Region: RecO_N; pfam11967 1306400006492 Recombination protein O C terminal; Region: RecO_C; pfam02565 1306400006493 amidase; Provisional; Region: PRK06061 1306400006494 Amidase; Region: Amidase; pfam01425 1306400006495 GTPase Era; Reviewed; Region: era; PRK00089 1306400006496 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1306400006497 G1 box; other site 1306400006498 GTP/Mg2+ binding site [chemical binding]; other site 1306400006499 Switch I region; other site 1306400006500 G2 box; other site 1306400006501 Switch II region; other site 1306400006502 G3 box; other site 1306400006503 G4 box; other site 1306400006504 G5 box; other site 1306400006505 KH domain; Region: KH_2; pfam07650 1306400006506 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1306400006507 Domain of unknown function DUF21; Region: DUF21; pfam01595 1306400006508 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1306400006509 Transporter associated domain; Region: CorC_HlyC; smart01091 1306400006510 metal-binding heat shock protein; Provisional; Region: PRK00016 1306400006511 K homology RNA-binding domain; Region: KH; smart00322 1306400006512 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1306400006513 PhoH-like protein; Region: PhoH; pfam02562 1306400006514 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1306400006515 PE family; Region: PE; pfam00934 1306400006516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1306400006517 RNA methyltransferase, RsmE family; Region: TIGR00046 1306400006518 chaperone protein DnaJ; Provisional; Region: PRK14278 1306400006519 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1306400006520 HSP70 interaction site [polypeptide binding]; other site 1306400006521 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1306400006522 Zn binding sites [ion binding]; other site 1306400006523 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1306400006524 dimer interface [polypeptide binding]; other site 1306400006525 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1306400006526 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306400006527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1306400006528 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400006529 Condensation domain; Region: Condensation; pfam00668 1306400006530 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306400006531 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1306400006532 acyl-activating enzyme (AAE) consensus motif; other site 1306400006533 AMP binding site [chemical binding]; other site 1306400006534 Condensation domain; Region: Condensation; pfam00668 1306400006535 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1306400006536 Condensation domain; Region: Condensation; pfam00668 1306400006537 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306400006538 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1306400006539 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1306400006540 acyl-activating enzyme (AAE) consensus motif; other site 1306400006541 AMP binding site [chemical binding]; other site 1306400006542 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306400006543 Condensation domain; Region: Condensation; pfam00668 1306400006544 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306400006545 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1306400006546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400006547 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306400006548 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306400006549 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400006550 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1306400006551 NADP binding site [chemical binding]; other site 1306400006552 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306400006553 active site 1306400006554 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400006555 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400006556 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306400006557 active site 1306400006558 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1306400006559 Condensation domain; Region: Condensation; pfam00668 1306400006560 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1306400006561 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1306400006562 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1306400006563 acyl-activating enzyme (AAE) consensus motif; other site 1306400006564 AMP binding site [chemical binding]; other site 1306400006565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306400006566 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1306400006567 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1306400006568 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1306400006569 acyl-activating enzyme (AAE) consensus motif; other site 1306400006570 active site 1306400006571 AMP binding site [chemical binding]; other site 1306400006572 substrate binding site [chemical binding]; other site 1306400006573 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1306400006574 salicylate synthase MbtI; Reviewed; Region: PRK07912 1306400006575 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1306400006576 Predicted permease [General function prediction only]; Region: COG3329 1306400006577 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1306400006578 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306400006579 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1306400006580 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1306400006581 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1306400006582 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1306400006583 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1306400006584 Active Sites [active] 1306400006585 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1306400006586 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1306400006587 putative active site [active] 1306400006588 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1306400006589 putative active site [active] 1306400006590 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1306400006591 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1306400006592 Predicted membrane protein [Function unknown]; Region: COG1297 1306400006593 putative oligopeptide transporter, OPT family; Region: TIGR00733 1306400006594 PE family; Region: PE; pfam00934 1306400006595 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1306400006596 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1306400006597 Walker A/P-loop; other site 1306400006598 ATP binding site [chemical binding]; other site 1306400006599 Q-loop/lid; other site 1306400006600 ABC transporter signature motif; other site 1306400006601 Walker B; other site 1306400006602 D-loop; other site 1306400006603 H-loop/switch region; other site 1306400006604 sulfate transport protein; Provisional; Region: cysT; CHL00187 1306400006605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400006606 dimer interface [polypeptide binding]; other site 1306400006607 conserved gate region; other site 1306400006608 putative PBP binding loops; other site 1306400006609 ABC-ATPase subunit interface; other site 1306400006610 sulfate transport protein; Provisional; Region: cysT; CHL00187 1306400006611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400006612 dimer interface [polypeptide binding]; other site 1306400006613 conserved gate region; other site 1306400006614 putative PBP binding loops; other site 1306400006615 ABC-ATPase subunit interface; other site 1306400006616 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1306400006617 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1306400006618 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1306400006619 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1306400006620 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306400006621 GTP-binding protein LepA; Provisional; Region: PRK05433 1306400006622 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1306400006623 G1 box; other site 1306400006624 putative GEF interaction site [polypeptide binding]; other site 1306400006625 GTP/Mg2+ binding site [chemical binding]; other site 1306400006626 Switch I region; other site 1306400006627 G2 box; other site 1306400006628 G3 box; other site 1306400006629 Switch II region; other site 1306400006630 G4 box; other site 1306400006631 G5 box; other site 1306400006632 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1306400006633 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1306400006634 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1306400006635 PemK-like protein; Region: PemK; pfam02452 1306400006636 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1306400006637 FOG: CBS domain [General function prediction only]; Region: COG0517 1306400006638 ribonuclease Z; Reviewed; Region: PRK00055 1306400006639 PE family; Region: PE; pfam00934 1306400006640 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306400006641 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1306400006642 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1306400006643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1306400006644 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1306400006645 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1306400006646 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1306400006647 hypothetical protein; Reviewed; Region: PRK07914 1306400006648 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1306400006649 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1306400006650 Competence protein; Region: Competence; pfam03772 1306400006651 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1306400006652 Helix-hairpin-helix motif; Region: HHH; pfam00633 1306400006653 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1306400006654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400006655 Coenzyme A binding pocket [chemical binding]; other site 1306400006656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1306400006657 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1306400006658 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1306400006659 active site 1306400006660 catalytic triad [active] 1306400006661 oxyanion hole [active] 1306400006662 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400006663 catalytic core [active] 1306400006664 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1306400006665 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1306400006666 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1306400006667 active site 1306400006668 (T/H)XGH motif; other site 1306400006669 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400006670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400006671 S-adenosylmethionine binding site [chemical binding]; other site 1306400006672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306400006673 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1306400006674 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1306400006675 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1306400006676 metal ion-dependent adhesion site (MIDAS); other site 1306400006677 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1306400006678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400006679 Walker A motif; other site 1306400006680 ATP binding site [chemical binding]; other site 1306400006681 Walker B motif; other site 1306400006682 arginine finger; other site 1306400006683 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1306400006684 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1306400006685 putative catalytic cysteine [active] 1306400006686 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1306400006687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1306400006688 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1306400006689 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1306400006690 dimer interface [polypeptide binding]; other site 1306400006691 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1306400006692 catalytic triad [active] 1306400006693 peroxidatic and resolving cysteines [active] 1306400006694 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1306400006695 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1306400006696 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400006697 PPE family; Region: PPE; pfam00823 1306400006698 PE family; Region: PE; pfam00934 1306400006699 potential frameshift: common BLAST hit: gi|471338430|ref|YP_007611143.1| transmembrane protein 1306400006700 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400006701 dimerization interface [polypeptide binding]; other site 1306400006702 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1306400006703 cyclase homology domain; Region: CHD; cd07302 1306400006704 nucleotidyl binding site; other site 1306400006705 metal binding site [ion binding]; metal-binding site 1306400006706 dimer interface [polypeptide binding]; other site 1306400006707 alpha-dioxygenase; Region: PLN02283 1306400006708 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1306400006709 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1306400006710 substrate binding site [chemical binding]; other site 1306400006711 dimer interface [polypeptide binding]; other site 1306400006712 ATP binding site [chemical binding]; other site 1306400006713 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1306400006714 NAD synthetase; Reviewed; Region: nadE; PRK02628 1306400006715 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1306400006716 multimer interface [polypeptide binding]; other site 1306400006717 active site 1306400006718 catalytic triad [active] 1306400006719 protein interface 1 [polypeptide binding]; other site 1306400006720 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1306400006721 homodimer interface [polypeptide binding]; other site 1306400006722 NAD binding pocket [chemical binding]; other site 1306400006723 ATP binding pocket [chemical binding]; other site 1306400006724 Mg binding site [ion binding]; other site 1306400006725 active-site loop [active] 1306400006726 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1306400006727 homotetrameric interface [polypeptide binding]; other site 1306400006728 putative allosteric binding site; other site 1306400006729 nucleotide binding site [chemical binding]; other site 1306400006730 PUA domain; Region: PUA; pfam01472 1306400006731 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1306400006732 GTP1/OBG; Region: GTP1_OBG; pfam01018 1306400006733 Obg GTPase; Region: Obg; cd01898 1306400006734 G1 box; other site 1306400006735 GTP/Mg2+ binding site [chemical binding]; other site 1306400006736 Switch I region; other site 1306400006737 G2 box; other site 1306400006738 G3 box; other site 1306400006739 Switch II region; other site 1306400006740 G4 box; other site 1306400006741 G5 box; other site 1306400006742 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1306400006743 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1306400006744 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1306400006745 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1306400006746 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1306400006747 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1306400006748 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1306400006749 homodimer interface [polypeptide binding]; other site 1306400006750 oligonucleotide binding site [chemical binding]; other site 1306400006751 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1306400006752 active site 1306400006753 multimer interface [polypeptide binding]; other site 1306400006754 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1306400006755 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1306400006756 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1306400006757 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1306400006758 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306400006759 active site 1306400006760 HIGH motif; other site 1306400006761 nucleotide binding site [chemical binding]; other site 1306400006762 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1306400006763 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1306400006764 active site 1306400006765 KMSKS motif; other site 1306400006766 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1306400006767 tRNA binding surface [nucleotide binding]; other site 1306400006768 anticodon binding site; other site 1306400006769 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1306400006770 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1306400006771 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1306400006772 NAD(P) binding pocket [chemical binding]; other site 1306400006773 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1306400006774 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1306400006775 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1306400006776 GTP binding site; other site 1306400006777 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1306400006778 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1306400006779 TPP-binding site [chemical binding]; other site 1306400006780 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1306400006781 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1306400006782 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1306400006783 dimer interface [polypeptide binding]; other site 1306400006784 PYR/PP interface [polypeptide binding]; other site 1306400006785 TPP binding site [chemical binding]; other site 1306400006786 substrate binding site [chemical binding]; other site 1306400006787 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1306400006788 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1306400006789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400006790 Walker A motif; other site 1306400006791 ATP binding site [chemical binding]; other site 1306400006792 Walker B motif; other site 1306400006793 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1306400006794 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1306400006795 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1306400006796 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1306400006797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400006798 putative substrate translocation pore; other site 1306400006799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400006800 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1306400006801 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1306400006802 oligomer interface [polypeptide binding]; other site 1306400006803 active site residues [active] 1306400006804 Clp protease; Region: CLP_protease; pfam00574 1306400006805 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1306400006806 oligomer interface [polypeptide binding]; other site 1306400006807 active site residues [active] 1306400006808 trigger factor; Provisional; Region: tig; PRK01490 1306400006809 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1306400006810 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1306400006811 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400006812 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400006813 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1306400006814 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1306400006815 putative DNA binding site [nucleotide binding]; other site 1306400006816 catalytic residue [active] 1306400006817 putative H2TH interface [polypeptide binding]; other site 1306400006818 putative catalytic residues [active] 1306400006819 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1306400006820 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1306400006821 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1306400006822 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1306400006823 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1306400006824 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1306400006825 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1306400006826 Zn binding site [ion binding]; other site 1306400006827 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1306400006828 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400006829 active site 1306400006830 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1306400006831 apolar tunnel; other site 1306400006832 heme binding site [chemical binding]; other site 1306400006833 dimerization interface [polypeptide binding]; other site 1306400006834 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1306400006835 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1306400006836 active site 1306400006837 catalytic site [active] 1306400006838 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1306400006839 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1306400006840 active site 1306400006841 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1306400006842 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1306400006843 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306400006844 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306400006845 ABC transporter; Region: ABC_tran_2; pfam12848 1306400006846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1306400006847 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1306400006848 dimer interface [polypeptide binding]; other site 1306400006849 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1306400006850 ssDNA binding site [nucleotide binding]; other site 1306400006851 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1306400006852 putative transposase OrfB; Reviewed; Region: PHA02517 1306400006853 HTH-like domain; Region: HTH_21; pfam13276 1306400006854 Integrase core domain; Region: rve; pfam00665 1306400006855 Integrase core domain; Region: rve_3; pfam13683 1306400006856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400006857 Transposase; Region: HTH_Tnp_1; cl17663 1306400006858 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1306400006859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1306400006860 putative acyl-acceptor binding pocket; other site 1306400006861 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1306400006862 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1306400006863 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400006864 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306400006865 putative acyl-acceptor binding pocket; other site 1306400006866 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400006867 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400006868 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1306400006869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400006870 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306400006871 enoyl-CoA hydratase; Provisional; Region: PRK05870 1306400006872 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400006873 substrate binding site [chemical binding]; other site 1306400006874 oxyanion hole (OAH) forming residues; other site 1306400006875 trimer interface [polypeptide binding]; other site 1306400006876 PE family; Region: PE; pfam00934 1306400006877 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1306400006878 cyclase homology domain; Region: CHD; cd07302 1306400006879 nucleotidyl binding site; other site 1306400006880 metal binding site [ion binding]; metal-binding site 1306400006881 dimer interface [polypeptide binding]; other site 1306400006882 AAA ATPase domain; Region: AAA_16; pfam13191 1306400006883 Predicted ATPase [General function prediction only]; Region: COG3903 1306400006884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306400006885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306400006886 DNA binding residues [nucleotide binding] 1306400006887 dimerization interface [polypeptide binding]; other site 1306400006888 PE family; Region: PE; pfam00934 1306400006889 TIGR00725 family protein; Region: TIGR00725 1306400006890 thymidylate synthase; Provisional; Region: thyA; PRK00956 1306400006891 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400006892 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1306400006893 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1306400006894 E3 interaction surface; other site 1306400006895 lipoyl attachment site [posttranslational modification]; other site 1306400006896 e3 binding domain; Region: E3_binding; pfam02817 1306400006897 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1306400006898 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1306400006899 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1306400006900 alpha subunit interface [polypeptide binding]; other site 1306400006901 TPP binding site [chemical binding]; other site 1306400006902 heterodimer interface [polypeptide binding]; other site 1306400006903 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1306400006904 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1306400006905 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1306400006906 tetramer interface [polypeptide binding]; other site 1306400006907 TPP-binding site [chemical binding]; other site 1306400006908 heterodimer interface [polypeptide binding]; other site 1306400006909 phosphorylation loop region [posttranslational modification] 1306400006910 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1306400006911 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1306400006912 putative active site [active] 1306400006913 putative catalytic site [active] 1306400006914 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400006915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400006916 active site 1306400006917 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1306400006918 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306400006919 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1306400006920 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1306400006921 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306400006922 carboxyltransferase (CT) interaction site; other site 1306400006923 biotinylation site [posttranslational modification]; other site 1306400006924 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306400006925 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1306400006926 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306400006927 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1306400006928 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1306400006929 AMP-binding domain protein; Validated; Region: PRK08315 1306400006930 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400006931 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1306400006932 acyl-activating enzyme (AAE) consensus motif; other site 1306400006933 acyl-activating enzyme (AAE) consensus motif; other site 1306400006934 putative AMP binding site [chemical binding]; other site 1306400006935 putative active site [active] 1306400006936 putative CoA binding site [chemical binding]; other site 1306400006937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400006938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400006939 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1306400006940 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1306400006941 classical (c) SDRs; Region: SDR_c; cd05233 1306400006942 NAD(P) binding site [chemical binding]; other site 1306400006943 active site 1306400006944 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1306400006945 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1306400006946 catalytic site [active] 1306400006947 putative active site [active] 1306400006948 putative substrate binding site [chemical binding]; other site 1306400006949 dimer interface [polypeptide binding]; other site 1306400006950 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400006951 MULE transposase domain; Region: MULE; pfam10551 1306400006952 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1306400006953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400006954 non-specific DNA binding site [nucleotide binding]; other site 1306400006955 salt bridge; other site 1306400006956 sequence-specific DNA binding site [nucleotide binding]; other site 1306400006957 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1306400006958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1306400006959 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1306400006960 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1306400006961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1306400006962 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1306400006963 PE family; Region: PE; pfam00934 1306400006964 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1306400006965 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1306400006966 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306400006967 catalytic triad [active] 1306400006968 hypothetical protein; Provisional; Region: PRK07907 1306400006969 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1306400006970 active site 1306400006971 metal binding site [ion binding]; metal-binding site 1306400006972 dimer interface [polypeptide binding]; other site 1306400006973 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1306400006974 potential frameshift: common BLAST hit: gi|385995451|ref|YP_005913749.1| fatty acid synthase 1306400006975 potential frameshift: common BLAST hit: gi|471338525|ref|YP_007611238.1| fatty acid synthase 1306400006976 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1306400006977 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306400006978 putative active site [active] 1306400006979 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1306400006980 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1306400006981 Restriction endonuclease; Region: Mrr_cat; pfam04471 1306400006982 ERCC4 domain; Region: ERCC4; pfam02732 1306400006983 Lsr2; Region: Lsr2; pfam11774 1306400006984 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306400006985 putative active site [active] 1306400006986 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1306400006987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306400006988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400006989 catalytic residue [active] 1306400006990 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1306400006991 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1306400006992 putative RNA binding site [nucleotide binding]; other site 1306400006993 elongation factor P; Validated; Region: PRK00529 1306400006994 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1306400006995 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1306400006996 RNA binding site [nucleotide binding]; other site 1306400006997 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1306400006998 RNA binding site [nucleotide binding]; other site 1306400006999 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1306400007000 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1306400007001 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1306400007002 active site 1306400007003 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1306400007004 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1306400007005 trimer interface [polypeptide binding]; other site 1306400007006 active site 1306400007007 dimer interface [polypeptide binding]; other site 1306400007008 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1306400007009 active site 1306400007010 dimer interface [polypeptide binding]; other site 1306400007011 metal binding site [ion binding]; metal-binding site 1306400007012 shikimate kinase; Reviewed; Region: aroK; PRK00131 1306400007013 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1306400007014 ADP binding site [chemical binding]; other site 1306400007015 magnesium binding site [ion binding]; other site 1306400007016 putative shikimate binding site; other site 1306400007017 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1306400007018 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1306400007019 Tetramer interface [polypeptide binding]; other site 1306400007020 active site 1306400007021 FMN-binding site [chemical binding]; other site 1306400007022 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1306400007023 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306400007024 putative active site [active] 1306400007025 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400007026 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1306400007027 oligomeric interface; other site 1306400007028 putative active site [active] 1306400007029 homodimer interface [polypeptide binding]; other site 1306400007030 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1306400007031 putative active site [active] 1306400007032 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400007033 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1306400007034 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1306400007035 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1306400007036 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1306400007037 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1306400007038 NAD(P) binding site [chemical binding]; other site 1306400007039 shikimate binding site; other site 1306400007040 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1306400007041 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1306400007042 dimerization interface [polypeptide binding]; other site 1306400007043 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1306400007044 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1306400007045 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1306400007046 motif 1; other site 1306400007047 active site 1306400007048 motif 2; other site 1306400007049 motif 3; other site 1306400007050 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1306400007051 DHHA1 domain; Region: DHHA1; pfam02272 1306400007052 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1306400007053 recombination factor protein RarA; Reviewed; Region: PRK13342 1306400007054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400007055 Walker A motif; other site 1306400007056 ATP binding site [chemical binding]; other site 1306400007057 Walker B motif; other site 1306400007058 arginine finger; other site 1306400007059 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1306400007060 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1306400007061 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1306400007062 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1306400007063 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1306400007064 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1306400007065 Walker A/P-loop; other site 1306400007066 ATP binding site [chemical binding]; other site 1306400007067 Q-loop/lid; other site 1306400007068 ABC transporter signature motif; other site 1306400007069 Walker B; other site 1306400007070 D-loop; other site 1306400007071 H-loop/switch region; other site 1306400007072 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306400007073 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306400007074 ligand binding site [chemical binding]; other site 1306400007075 flexible hinge region; other site 1306400007076 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306400007077 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306400007078 ligand binding site [chemical binding]; other site 1306400007079 flexible hinge region; other site 1306400007080 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306400007081 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1306400007082 active site 1306400007083 nucleophile elbow; other site 1306400007084 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306400007085 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1306400007086 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1306400007087 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1306400007088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1306400007089 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1306400007090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1306400007091 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1306400007092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1306400007093 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1306400007094 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1306400007095 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1306400007096 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1306400007097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1306400007098 Predicted membrane protein [Function unknown]; Region: COG4129 1306400007099 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1306400007100 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1306400007101 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1306400007102 dimer interface [polypeptide binding]; other site 1306400007103 anticodon binding site; other site 1306400007104 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1306400007105 homodimer interface [polypeptide binding]; other site 1306400007106 motif 1; other site 1306400007107 active site 1306400007108 motif 2; other site 1306400007109 GAD domain; Region: GAD; pfam02938 1306400007110 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306400007111 active site 1306400007112 motif 3; other site 1306400007113 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1306400007114 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1306400007115 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1306400007116 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1306400007117 putative hydrophobic ligand binding site [chemical binding]; other site 1306400007118 protein interface [polypeptide binding]; other site 1306400007119 gate; other site 1306400007120 Predicted metalloprotease [General function prediction only]; Region: COG2321 1306400007121 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1306400007122 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1306400007123 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1306400007124 active site 1306400007125 metal binding site [ion binding]; metal-binding site 1306400007126 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1306400007127 haloalkane dehalogenase; Provisional; Region: PRK03592 1306400007128 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1306400007129 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1306400007130 dimer interface [polypeptide binding]; other site 1306400007131 motif 1; other site 1306400007132 active site 1306400007133 motif 2; other site 1306400007134 motif 3; other site 1306400007135 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1306400007136 anticodon binding site; other site 1306400007137 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1306400007138 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1306400007139 active site 1306400007140 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1306400007141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1306400007142 Zn2+ binding site [ion binding]; other site 1306400007143 Mg2+ binding site [ion binding]; other site 1306400007144 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1306400007145 synthetase active site [active] 1306400007146 NTP binding site [chemical binding]; other site 1306400007147 metal binding site [ion binding]; metal-binding site 1306400007148 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1306400007149 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1306400007150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400007151 active site 1306400007152 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1306400007153 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1306400007154 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1306400007155 Protein export membrane protein; Region: SecD_SecF; pfam02355 1306400007156 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1306400007157 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1306400007158 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1306400007159 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1306400007160 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306400007161 inhibitor-cofactor binding pocket; inhibition site 1306400007162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400007163 catalytic residue [active] 1306400007164 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1306400007165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400007166 acyl-activating enzyme (AAE) consensus motif; other site 1306400007167 AMP binding site [chemical binding]; other site 1306400007168 active site 1306400007169 CoA binding site [chemical binding]; other site 1306400007170 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1306400007171 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1306400007172 putative NAD(P) binding site [chemical binding]; other site 1306400007173 active site 1306400007174 putative substrate binding site [chemical binding]; other site 1306400007175 PE family; Region: PE; pfam00934 1306400007176 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1306400007177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400007178 Walker A motif; other site 1306400007179 ATP binding site [chemical binding]; other site 1306400007180 Walker B motif; other site 1306400007181 arginine finger; other site 1306400007182 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1306400007183 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1306400007184 RuvA N terminal domain; Region: RuvA_N; pfam01330 1306400007185 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1306400007186 active site 1306400007187 putative DNA-binding cleft [nucleotide binding]; other site 1306400007188 dimer interface [polypeptide binding]; other site 1306400007189 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1306400007190 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1306400007191 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306400007192 putative active site [active] 1306400007193 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1306400007194 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1306400007195 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1306400007196 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1306400007197 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1306400007198 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1306400007199 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1306400007200 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400007201 hypothetical protein; Validated; Region: PRK00110 1306400007202 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1306400007203 predicted active site [active] 1306400007204 catalytic triad [active] 1306400007205 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1306400007206 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1306400007207 active site 1306400007208 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1306400007209 catalytic triad [active] 1306400007210 dimer interface [polypeptide binding]; other site 1306400007211 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1306400007212 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1306400007213 active site 1306400007214 multimer interface [polypeptide binding]; other site 1306400007215 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1306400007216 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1306400007217 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1306400007218 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400007219 PPE family; Region: PPE; pfam00823 1306400007220 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400007221 PPE family; Region: PPE; pfam00823 1306400007222 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400007223 PE-PPE domain; Region: PE-PPE; pfam08237 1306400007224 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1306400007225 nudix motif; other site 1306400007226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306400007227 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306400007228 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1306400007229 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1306400007230 putative acyl-acceptor binding pocket; other site 1306400007231 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1306400007232 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1306400007233 nucleotide binding site/active site [active] 1306400007234 HIT family signature motif; other site 1306400007235 catalytic residue [active] 1306400007236 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1306400007237 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1306400007238 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1306400007239 active site 1306400007240 dimer interface [polypeptide binding]; other site 1306400007241 motif 1; other site 1306400007242 motif 2; other site 1306400007243 motif 3; other site 1306400007244 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1306400007245 anticodon binding site; other site 1306400007246 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306400007247 phosphate binding site [ion binding]; other site 1306400007248 PE family; Region: PE; pfam00934 1306400007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1306400007250 Predicted transcriptional regulator [Transcription]; Region: COG2345 1306400007251 Helix-turn-helix domain; Region: HTH_20; pfam12840 1306400007252 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1306400007253 Predicted transcriptional regulator [Transcription]; Region: COG2345 1306400007254 Helix-turn-helix domain; Region: HTH_20; pfam12840 1306400007255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400007256 S-adenosylmethionine binding site [chemical binding]; other site 1306400007257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306400007258 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400007259 Ligand Binding Site [chemical binding]; other site 1306400007260 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400007261 Ligand Binding Site [chemical binding]; other site 1306400007262 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400007263 Ligand Binding Site [chemical binding]; other site 1306400007264 Universal stress protein family; Region: Usp; pfam00582 1306400007265 Ligand Binding Site [chemical binding]; other site 1306400007266 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1306400007267 active site 1306400007268 Peptidase family M50; Region: Peptidase_M50; pfam02163 1306400007269 putative substrate binding region [chemical binding]; other site 1306400007270 FOG: CBS domain [General function prediction only]; Region: COG0517 1306400007271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1306400007272 FOG: CBS domain [General function prediction only]; Region: COG0517 1306400007273 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1306400007274 peptide chain release factor 1; Provisional; Region: PRK04011 1306400007275 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1306400007276 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1306400007277 hypothetical protein; Reviewed; Region: PRK09588 1306400007278 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1306400007279 Hemerythrin-like domain; Region: Hr-like; cd12108 1306400007280 Fe binding site [ion binding]; other site 1306400007281 PE family; Region: PE; pfam00934 1306400007282 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1306400007283 P-loop motif; other site 1306400007284 ATP binding site [chemical binding]; other site 1306400007285 Chloramphenicol (Cm) binding site [chemical binding]; other site 1306400007286 catalytic residue [active] 1306400007287 potential frameshift: common BLAST hit: gi|471338645|ref|YP_007611358.1| transmembrane protein 1306400007288 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306400007289 anti sigma factor interaction site; other site 1306400007290 regulatory phosphorylation site [posttranslational modification]; other site 1306400007291 hypothetical protein; Provisional; Region: PRK02237 1306400007292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400007293 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1306400007294 putative DNA binding site [nucleotide binding]; other site 1306400007295 putative Zn2+ binding site [ion binding]; other site 1306400007296 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1306400007297 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1306400007298 putative metal binding site [ion binding]; other site 1306400007299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400007300 dimerization interface [polypeptide binding]; other site 1306400007301 putative DNA binding site [nucleotide binding]; other site 1306400007302 putative Zn2+ binding site [ion binding]; other site 1306400007303 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1306400007304 arsenical-resistance protein; Region: acr3; TIGR00832 1306400007305 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1306400007306 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1306400007307 active site 1306400007308 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1306400007309 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1306400007310 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1306400007311 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306400007312 active site 1306400007313 DNA binding site [nucleotide binding] 1306400007314 Int/Topo IB signature motif; other site 1306400007315 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1306400007316 ParB-like nuclease domain; Region: ParBc; cl02129 1306400007317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400007318 Transposase; Region: HTH_Tnp_1; cl17663 1306400007319 putative transposase OrfB; Reviewed; Region: PHA02517 1306400007320 HTH-like domain; Region: HTH_21; pfam13276 1306400007321 Integrase core domain; Region: rve; pfam00665 1306400007322 Integrase core domain; Region: rve_3; pfam13683 1306400007323 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1306400007324 Phage capsid family; Region: Phage_capsid; pfam05065 1306400007325 Phage head maturation protease [General function prediction only]; Region: COG3740 1306400007326 Phage terminase, small subunit; Region: Terminase_4; cl01525 1306400007327 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1306400007328 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1306400007329 DNA binding domain, excisionase family; Region: excise; TIGR01764 1306400007330 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1306400007331 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1306400007332 active site 1306400007333 catalytic residues [active] 1306400007334 DNA binding site [nucleotide binding] 1306400007335 Int/Topo IB signature motif; other site 1306400007336 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400007337 MULE transposase domain; Region: MULE; pfam10551 1306400007338 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1306400007339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1306400007340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400007341 Coenzyme A binding pocket [chemical binding]; other site 1306400007342 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1306400007343 hypothetical protein; Provisional; Region: PRK14059 1306400007344 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1306400007345 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400007346 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306400007347 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1306400007348 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1306400007349 SelR domain; Region: SelR; pfam01641 1306400007350 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306400007351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400007352 S-adenosylmethionine binding site [chemical binding]; other site 1306400007353 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1306400007354 potential frameshift: common BLAST hit: gi|449064744|ref|YP_007431827.1| protoporphyrinogen oxidase 1306400007355 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1306400007356 substrate binding site [chemical binding]; other site 1306400007357 active site 1306400007358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400007359 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306400007360 substrate binding site [chemical binding]; other site 1306400007361 oxyanion hole (OAH) forming residues; other site 1306400007362 trimer interface [polypeptide binding]; other site 1306400007363 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1306400007364 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1306400007365 catalytic site [active] 1306400007366 putative active site [active] 1306400007367 putative substrate binding site [chemical binding]; other site 1306400007368 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1306400007369 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1306400007370 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1306400007371 TPP-binding site; other site 1306400007372 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1306400007373 PYR/PP interface [polypeptide binding]; other site 1306400007374 dimer interface [polypeptide binding]; other site 1306400007375 TPP binding site [chemical binding]; other site 1306400007376 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1306400007377 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1306400007378 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1306400007379 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1306400007380 transmembrane helices; other site 1306400007381 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1306400007382 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1306400007383 transmembrane helices; other site 1306400007384 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1306400007385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1306400007386 Walker A/P-loop; other site 1306400007387 ATP binding site [chemical binding]; other site 1306400007388 Q-loop/lid; other site 1306400007389 ABC transporter signature motif; other site 1306400007390 Walker B; other site 1306400007391 D-loop; other site 1306400007392 H-loop/switch region; other site 1306400007393 TRAM domain; Region: TRAM; cl01282 1306400007394 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1306400007395 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1306400007396 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1306400007397 TrkA-N domain; Region: TrkA_N; pfam02254 1306400007398 TrkA-C domain; Region: TrkA_C; pfam02080 1306400007399 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1306400007400 TrkA-N domain; Region: TrkA_N; pfam02254 1306400007401 TrkA-C domain; Region: TrkA_C; pfam02080 1306400007402 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1306400007403 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1306400007404 generic binding surface II; other site 1306400007405 ssDNA binding site; other site 1306400007406 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1306400007407 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1306400007408 trimer interface [polypeptide binding]; other site 1306400007409 active site 1306400007410 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1306400007411 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1306400007412 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306400007413 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1306400007414 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1306400007415 active site 1306400007416 dimerization interface [polypeptide binding]; other site 1306400007417 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1306400007418 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306400007419 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1306400007420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400007421 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1306400007422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400007423 DNA binding residues [nucleotide binding] 1306400007424 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1306400007425 homotrimer interaction site [polypeptide binding]; other site 1306400007426 putative active site [active] 1306400007427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1306400007428 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1306400007429 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1306400007430 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1306400007431 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1306400007432 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1306400007433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400007434 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1306400007435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400007436 DNA binding residues [nucleotide binding] 1306400007437 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1306400007438 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1306400007439 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1306400007440 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1306400007441 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1306400007442 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1306400007443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400007444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400007445 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306400007446 PAC2 family; Region: PAC2; pfam09754 1306400007447 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400007448 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1306400007449 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1306400007450 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1306400007451 heme-binding site [chemical binding]; other site 1306400007452 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1306400007453 ATP cone domain; Region: ATP-cone; pfam03477 1306400007454 LysM domain; Region: LysM; pfam01476 1306400007455 LexA repressor; Validated; Region: PRK00215 1306400007456 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1306400007457 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1306400007458 Catalytic site [active] 1306400007459 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1306400007460 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1306400007461 LGFP repeat; Region: LGFP; pfam08310 1306400007462 LGFP repeat; Region: LGFP; pfam08310 1306400007463 LGFP repeat; Region: LGFP; pfam08310 1306400007464 LGFP repeat; Region: LGFP; pfam08310 1306400007465 LGFP repeat; Region: LGFP; pfam08310 1306400007466 Integral membrane protein TerC family; Region: TerC; cl10468 1306400007467 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400007468 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400007469 active site 1306400007470 GTPases [General function prediction only]; Region: HflX; COG2262 1306400007471 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1306400007472 HflX GTPase family; Region: HflX; cd01878 1306400007473 G1 box; other site 1306400007474 GTP/Mg2+ binding site [chemical binding]; other site 1306400007475 Switch I region; other site 1306400007476 G2 box; other site 1306400007477 G3 box; other site 1306400007478 Switch II region; other site 1306400007479 G4 box; other site 1306400007480 G5 box; other site 1306400007481 diaminopimelate epimerase; Region: DapF; TIGR00652 1306400007482 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1306400007483 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1306400007484 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1306400007485 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1306400007486 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1306400007487 active site 1306400007488 metal binding site [ion binding]; metal-binding site 1306400007489 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1306400007490 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1306400007491 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1306400007492 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1306400007493 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1306400007494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400007495 FeS/SAM binding site; other site 1306400007496 TRAM domain; Region: TRAM; cl01282 1306400007497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400007498 FeS/SAM binding site; other site 1306400007499 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1306400007500 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 1306400007501 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1306400007502 hexamer interface [polypeptide binding]; other site 1306400007503 Walker A motif; other site 1306400007504 ATP binding site [chemical binding]; other site 1306400007505 Walker B motif; other site 1306400007506 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1306400007507 protein-splicing catalytic site; other site 1306400007508 thioester formation/cholesterol transfer; other site 1306400007509 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1306400007510 recA bacterial DNA recombination protein; Region: RecA; cl17211 1306400007511 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1306400007512 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1306400007513 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306400007514 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1306400007515 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1306400007516 PE family; Region: PE; pfam00934 1306400007517 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1306400007518 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1306400007519 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1306400007520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400007521 non-specific DNA binding site [nucleotide binding]; other site 1306400007522 salt bridge; other site 1306400007523 sequence-specific DNA binding site [nucleotide binding]; other site 1306400007524 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1306400007525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400007526 Coenzyme A binding pocket [chemical binding]; other site 1306400007527 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1306400007528 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400007529 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1306400007530 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1306400007531 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1306400007532 classical (c) SDRs; Region: SDR_c; cd05233 1306400007533 NAD(P) binding site [chemical binding]; other site 1306400007534 active site 1306400007535 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400007536 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400007537 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1306400007538 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306400007539 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1306400007540 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1306400007541 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1306400007542 dimer interface [polypeptide binding]; other site 1306400007543 active site 1306400007544 catalytic residue [active] 1306400007545 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1306400007546 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1306400007547 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1306400007548 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1306400007549 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1306400007550 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1306400007551 putative active site [active] 1306400007552 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1306400007553 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1306400007554 putative active site [active] 1306400007555 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1306400007556 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1306400007557 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1306400007558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1306400007559 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1306400007560 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1306400007561 folate binding site [chemical binding]; other site 1306400007562 NADP+ binding site [chemical binding]; other site 1306400007563 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1306400007564 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1306400007565 dimerization interface [polypeptide binding]; other site 1306400007566 active site 1306400007567 Dienelactone hydrolase family; Region: DLH; pfam01738 1306400007568 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1306400007569 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1306400007570 classical (c) SDRs; Region: SDR_c; cd05233 1306400007571 NAD(P) binding site [chemical binding]; other site 1306400007572 active site 1306400007573 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400007574 PPE family; Region: PPE; pfam00823 1306400007575 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400007576 PE family; Region: PE; pfam00934 1306400007577 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400007578 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400007579 PPE family; Region: PPE; pfam00823 1306400007580 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1306400007581 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1306400007582 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1306400007583 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1306400007584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1306400007585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400007586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1306400007587 Coenzyme A binding pocket [chemical binding]; other site 1306400007588 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1306400007589 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1306400007590 FMN-binding pocket [chemical binding]; other site 1306400007591 flavin binding motif; other site 1306400007592 phosphate binding motif [ion binding]; other site 1306400007593 beta-alpha-beta structure motif; other site 1306400007594 NAD binding pocket [chemical binding]; other site 1306400007595 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306400007596 catalytic loop [active] 1306400007597 iron binding site [ion binding]; other site 1306400007598 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1306400007599 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1306400007600 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1306400007601 hydrophobic ligand binding site; other site 1306400007602 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1306400007603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400007604 putative DNA binding site [nucleotide binding]; other site 1306400007605 putative Zn2+ binding site [ion binding]; other site 1306400007606 AsnC family; Region: AsnC_trans_reg; pfam01037 1306400007607 alanine dehydrogenase; Region: alaDH; TIGR00518 1306400007608 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1306400007609 hexamer interface [polypeptide binding]; other site 1306400007610 ligand binding site [chemical binding]; other site 1306400007611 putative active site [active] 1306400007612 NAD(P) binding site [chemical binding]; other site 1306400007613 Nitronate monooxygenase; Region: NMO; pfam03060 1306400007614 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306400007615 FMN binding site [chemical binding]; other site 1306400007616 substrate binding site [chemical binding]; other site 1306400007617 putative catalytic residue [active] 1306400007618 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1306400007619 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1306400007620 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1306400007621 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1306400007622 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1306400007623 oligomer interface [polypeptide binding]; other site 1306400007624 RNA binding site [nucleotide binding]; other site 1306400007625 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1306400007626 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1306400007627 RNase E interface [polypeptide binding]; other site 1306400007628 trimer interface [polypeptide binding]; other site 1306400007629 active site 1306400007630 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1306400007631 putative nucleic acid binding region [nucleotide binding]; other site 1306400007632 G-X-X-G motif; other site 1306400007633 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1306400007634 RNA binding site [nucleotide binding]; other site 1306400007635 domain interface; other site 1306400007636 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1306400007637 16S/18S rRNA binding site [nucleotide binding]; other site 1306400007638 S13e-L30e interaction site [polypeptide binding]; other site 1306400007639 25S rRNA binding site [nucleotide binding]; other site 1306400007640 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1306400007641 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1306400007642 active site 1306400007643 Riboflavin kinase; Region: Flavokinase; pfam01687 1306400007644 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306400007645 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1306400007646 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1306400007647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400007648 putative DNA binding site [nucleotide binding]; other site 1306400007649 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1306400007650 FeoA domain; Region: FeoA; pfam04023 1306400007651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400007652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400007653 active site 1306400007654 lipid-transfer protein; Provisional; Region: PRK08256 1306400007655 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306400007656 active site 1306400007657 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306400007658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306400007659 Probable transposase; Region: OrfB_IS605; pfam01385 1306400007660 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306400007661 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1306400007662 catalytic residues [active] 1306400007663 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1306400007664 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1306400007665 RNA binding site [nucleotide binding]; other site 1306400007666 active site 1306400007667 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1306400007668 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1306400007669 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1306400007670 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1306400007671 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1306400007672 active site 1306400007673 metal binding site [ion binding]; metal-binding site 1306400007674 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1306400007675 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1306400007676 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1306400007677 Predicted acyl esterases [General function prediction only]; Region: COG2936 1306400007678 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1306400007679 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1306400007680 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1306400007681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1306400007682 Integrase core domain; Region: rve; pfam00665 1306400007683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306400007684 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306400007685 Helix-turn-helix domain; Region: HTH_28; pfam13518 1306400007686 Winged helix-turn helix; Region: HTH_29; pfam13551 1306400007687 Integrase core domain; Region: rve; pfam00665 1306400007688 Integrase core domain; Region: rve_3; pfam13683 1306400007689 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1306400007690 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1306400007691 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1306400007692 putative transposase OrfB; Reviewed; Region: PHA02517 1306400007693 HTH-like domain; Region: HTH_21; pfam13276 1306400007694 Integrase core domain; Region: rve; pfam00665 1306400007695 Integrase core domain; Region: rve_3; pfam13683 1306400007696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400007697 Transposase; Region: HTH_Tnp_1; cl17663 1306400007698 potential frameshift: common BLAST hit: gi|397674730|ref|YP_006516265.1| CRISPR-associated endoribonuclease cas2 1306400007699 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1306400007700 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 1306400007701 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 1306400007702 potential frameshift: common BLAST hit: gi|397674734|ref|YP_006516269.1| CRISPR type III-a/mtube-associated ramp protein csm4 1306400007703 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1306400007704 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1306400007705 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1306400007706 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1306400007707 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1306400007708 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1306400007709 Uncharacterized conserved protein [Function unknown]; Region: COG2253 1306400007710 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 1306400007711 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1306400007712 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1306400007713 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1306400007714 putative active site [active] 1306400007715 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400007716 enoyl-CoA hydratase; Provisional; Region: PRK06190 1306400007717 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400007718 substrate binding site [chemical binding]; other site 1306400007719 oxyanion hole (OAH) forming residues; other site 1306400007720 trimer interface [polypeptide binding]; other site 1306400007721 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1306400007722 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1306400007723 Walker A/P-loop; other site 1306400007724 ATP binding site [chemical binding]; other site 1306400007725 Q-loop/lid; other site 1306400007726 ABC transporter signature motif; other site 1306400007727 Walker B; other site 1306400007728 D-loop; other site 1306400007729 H-loop/switch region; other site 1306400007730 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1306400007731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1306400007732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1306400007733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400007734 dimer interface [polypeptide binding]; other site 1306400007735 conserved gate region; other site 1306400007736 putative PBP binding loops; other site 1306400007737 ABC-ATPase subunit interface; other site 1306400007738 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1306400007739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400007740 dimer interface [polypeptide binding]; other site 1306400007741 conserved gate region; other site 1306400007742 putative PBP binding loops; other site 1306400007743 ABC-ATPase subunit interface; other site 1306400007744 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1306400007745 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1306400007746 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1306400007747 DHH family; Region: DHH; pfam01368 1306400007748 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1306400007749 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1306400007750 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1306400007751 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1306400007752 G1 box; other site 1306400007753 putative GEF interaction site [polypeptide binding]; other site 1306400007754 GTP/Mg2+ binding site [chemical binding]; other site 1306400007755 Switch I region; other site 1306400007756 G2 box; other site 1306400007757 G3 box; other site 1306400007758 Switch II region; other site 1306400007759 G4 box; other site 1306400007760 G5 box; other site 1306400007761 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1306400007762 Translation-initiation factor 2; Region: IF-2; pfam11987 1306400007763 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1306400007764 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1306400007765 putative RNA binding cleft [nucleotide binding]; other site 1306400007766 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1306400007767 NusA N-terminal domain; Region: NusA_N; pfam08529 1306400007768 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1306400007769 RNA binding site [nucleotide binding]; other site 1306400007770 homodimer interface [polypeptide binding]; other site 1306400007771 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1306400007772 G-X-X-G motif; other site 1306400007773 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1306400007774 G-X-X-G motif; other site 1306400007775 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1306400007776 Sm and related proteins; Region: Sm_like; cl00259 1306400007777 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1306400007778 putative oligomer interface [polypeptide binding]; other site 1306400007779 putative RNA binding site [nucleotide binding]; other site 1306400007780 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1306400007781 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1306400007782 dinuclear metal binding motif [ion binding]; other site 1306400007783 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1306400007784 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1306400007785 dimer interface [polypeptide binding]; other site 1306400007786 motif 1; other site 1306400007787 active site 1306400007788 motif 2; other site 1306400007789 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1306400007790 putative deacylase active site [active] 1306400007791 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306400007792 active site 1306400007793 motif 3; other site 1306400007794 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1306400007795 anticodon binding site; other site 1306400007796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400007797 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306400007798 putative substrate translocation pore; other site 1306400007799 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1306400007800 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1306400007801 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1306400007802 homodimer interface [polypeptide binding]; other site 1306400007803 active site 1306400007804 SAM binding site [chemical binding]; other site 1306400007805 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1306400007806 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1306400007807 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1306400007808 catalytic triad [active] 1306400007809 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1306400007810 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1306400007811 homodimer interface [polypeptide binding]; other site 1306400007812 Walker A motif; other site 1306400007813 ATP binding site [chemical binding]; other site 1306400007814 hydroxycobalamin binding site [chemical binding]; other site 1306400007815 Walker B motif; other site 1306400007816 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1306400007817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400007818 Walker A motif; other site 1306400007819 ATP binding site [chemical binding]; other site 1306400007820 Walker B motif; other site 1306400007821 arginine finger; other site 1306400007822 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1306400007823 metal ion-dependent adhesion site (MIDAS); other site 1306400007824 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1306400007825 malate:quinone oxidoreductase; Validated; Region: PRK05257 1306400007826 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1306400007827 PE family; Region: PE; pfam00934 1306400007828 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1306400007829 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306400007830 mycothione reductase; Reviewed; Region: PRK07846 1306400007831 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400007832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400007833 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306400007834 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1306400007835 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1306400007836 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1306400007837 short chain dehydrogenase; Provisional; Region: PRK06057 1306400007838 classical (c) SDRs; Region: SDR_c; cd05233 1306400007839 NAD(P) binding site [chemical binding]; other site 1306400007840 active site 1306400007841 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1306400007842 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1306400007843 NAD(P) binding site [chemical binding]; other site 1306400007844 catalytic residues [active] 1306400007845 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1306400007846 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1306400007847 catalytic triad [active] 1306400007848 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1306400007849 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1306400007850 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1306400007851 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1306400007852 active site 1306400007853 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1306400007854 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1306400007855 putative active site [active] 1306400007856 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1306400007857 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1306400007858 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1306400007859 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1306400007860 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1306400007861 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1306400007862 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1306400007863 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1306400007864 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1306400007865 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1306400007866 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1306400007867 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1306400007868 active site 1306400007869 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1306400007870 protein binding site [polypeptide binding]; other site 1306400007871 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1306400007872 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1306400007873 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1306400007874 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1306400007875 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400007876 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400007877 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1306400007878 Fasciclin domain; Region: Fasciclin; pfam02469 1306400007879 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400007880 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1306400007881 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1306400007882 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1306400007883 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306400007884 catalytic residues [active] 1306400007885 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1306400007886 Fasciclin domain; Region: Fasciclin; pfam02469 1306400007887 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1306400007888 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1306400007889 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1306400007890 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306400007891 catalytic residues [active] 1306400007892 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1306400007893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400007894 FeS/SAM binding site; other site 1306400007895 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1306400007896 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1306400007897 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1306400007898 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1306400007899 hinge region; other site 1306400007900 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1306400007901 putative nucleotide binding site [chemical binding]; other site 1306400007902 uridine monophosphate binding site [chemical binding]; other site 1306400007903 homohexameric interface [polypeptide binding]; other site 1306400007904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400007905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400007906 DNA binding site [nucleotide binding] 1306400007907 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306400007908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306400007909 Probable transposase; Region: OrfB_IS605; pfam01385 1306400007910 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306400007911 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1306400007912 catalytic residues [active] 1306400007913 catalytic nucleophile [active] 1306400007914 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1306400007915 MarR family; Region: MarR; pfam01047 1306400007916 amidase; Provisional; Region: PRK07869 1306400007917 Amidase; Region: Amidase; pfam01425 1306400007918 elongation factor Ts; Provisional; Region: tsf; PRK09377 1306400007919 UBA/TS-N domain; Region: UBA; pfam00627 1306400007920 Elongation factor TS; Region: EF_TS; pfam00889 1306400007921 Elongation factor TS; Region: EF_TS; pfam00889 1306400007922 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1306400007923 rRNA interaction site [nucleotide binding]; other site 1306400007924 S8 interaction site; other site 1306400007925 putative laminin-1 binding site; other site 1306400007926 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1306400007927 Peptidase family M23; Region: Peptidase_M23; pfam01551 1306400007928 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400007929 PPE family; Region: PPE; pfam00823 1306400007930 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400007931 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1306400007932 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400007933 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1306400007934 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306400007935 active site 1306400007936 DNA binding site [nucleotide binding] 1306400007937 Int/Topo IB signature motif; other site 1306400007938 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1306400007939 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1306400007940 FAD binding pocket [chemical binding]; other site 1306400007941 FAD binding motif [chemical binding]; other site 1306400007942 phosphate binding motif [ion binding]; other site 1306400007943 NAD binding pocket [chemical binding]; other site 1306400007944 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1306400007945 DNA protecting protein DprA; Region: dprA; TIGR00732 1306400007946 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1306400007947 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1306400007948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400007949 Walker A motif; other site 1306400007950 ATP binding site [chemical binding]; other site 1306400007951 Walker B motif; other site 1306400007952 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1306400007953 hypothetical protein; Reviewed; Region: PRK12497 1306400007954 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1306400007955 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1306400007956 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1306400007957 putative molybdopterin cofactor binding site [chemical binding]; other site 1306400007958 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1306400007959 putative molybdopterin cofactor binding site; other site 1306400007960 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1306400007961 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1306400007962 RNA/DNA hybrid binding site [nucleotide binding]; other site 1306400007963 active site 1306400007964 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1306400007965 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1306400007966 Catalytic site [active] 1306400007967 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1306400007968 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1306400007969 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1306400007970 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1306400007971 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1306400007972 RimM N-terminal domain; Region: RimM; pfam01782 1306400007973 hypothetical protein; Provisional; Region: PRK02821 1306400007974 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1306400007975 G-X-X-G motif; other site 1306400007976 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1306400007977 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1306400007978 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1306400007979 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1306400007980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400007981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400007982 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1306400007983 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1306400007984 active site 1306400007985 putative substrate binding pocket [chemical binding]; other site 1306400007986 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1306400007987 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400007988 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400007989 active site 1306400007990 ATP binding site [chemical binding]; other site 1306400007991 substrate binding site [chemical binding]; other site 1306400007992 activation loop (A-loop); other site 1306400007993 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1306400007994 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1306400007995 active site 1306400007996 signal recognition particle protein; Provisional; Region: PRK10867 1306400007997 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1306400007998 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1306400007999 P loop; other site 1306400008000 GTP binding site [chemical binding]; other site 1306400008001 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1306400008002 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1306400008003 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1306400008004 ATP binding site [chemical binding]; other site 1306400008005 putative Mg++ binding site [ion binding]; other site 1306400008006 PII uridylyl-transferase; Provisional; Region: PRK03381 1306400008007 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1306400008008 metal binding triad; other site 1306400008009 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1306400008010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1306400008011 Zn2+ binding site [ion binding]; other site 1306400008012 Mg2+ binding site [ion binding]; other site 1306400008013 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1306400008014 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1306400008015 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1306400008016 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1306400008017 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1306400008018 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1306400008019 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1306400008020 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1306400008021 Walker A/P-loop; other site 1306400008022 ATP binding site [chemical binding]; other site 1306400008023 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1306400008024 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1306400008025 ABC transporter signature motif; other site 1306400008026 Walker B; other site 1306400008027 D-loop; other site 1306400008028 H-loop/switch region; other site 1306400008029 acylphosphatase; Provisional; Region: PRK14422 1306400008030 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1306400008031 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1306400008032 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1306400008033 DNA binding site [nucleotide binding] 1306400008034 catalytic residue [active] 1306400008035 H2TH interface [polypeptide binding]; other site 1306400008036 putative catalytic residues [active] 1306400008037 turnover-facilitating residue; other site 1306400008038 intercalation triad [nucleotide binding]; other site 1306400008039 8OG recognition residue [nucleotide binding]; other site 1306400008040 putative reading head residues; other site 1306400008041 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1306400008042 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1306400008043 ribonuclease III; Reviewed; Region: rnc; PRK00102 1306400008044 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1306400008045 dimerization interface [polypeptide binding]; other site 1306400008046 active site 1306400008047 metal binding site [ion binding]; metal-binding site 1306400008048 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1306400008049 dsRNA binding site [nucleotide binding]; other site 1306400008050 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1306400008051 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1306400008052 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1306400008053 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1306400008054 acyl-CoA synthetase; Validated; Region: PRK05850 1306400008055 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400008056 acyl-activating enzyme (AAE) consensus motif; other site 1306400008057 active site 1306400008058 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306400008059 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400008060 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400008061 active site 1306400008062 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1306400008063 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400008064 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1306400008065 NADP binding site [chemical binding]; other site 1306400008066 KR domain; Region: KR; pfam08659 1306400008067 active site 1306400008068 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400008069 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400008070 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306400008071 active site 1306400008072 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400008073 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1306400008074 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1306400008075 KR domain; Region: KR; pfam08659 1306400008076 NADP binding site [chemical binding]; other site 1306400008077 active site 1306400008078 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400008079 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400008080 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400008081 active site 1306400008082 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1306400008083 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400008084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400008085 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400008086 Enoylreductase; Region: PKS_ER; smart00829 1306400008087 NAD(P) binding site [chemical binding]; other site 1306400008088 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306400008089 KR domain; Region: KR; pfam08659 1306400008090 putative NADP binding site [chemical binding]; other site 1306400008091 active site 1306400008092 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400008093 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400008094 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400008095 active site 1306400008096 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400008097 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400008098 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306400008099 KR domain; Region: KR; pfam08659 1306400008100 putative NADP binding site [chemical binding]; other site 1306400008101 active site 1306400008102 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400008103 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400008104 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400008105 active site 1306400008106 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400008107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1306400008108 Condensation domain; Region: Condensation; pfam00668 1306400008109 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1306400008110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400008111 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1306400008112 Walker A/P-loop; other site 1306400008113 ATP binding site [chemical binding]; other site 1306400008114 Q-loop/lid; other site 1306400008115 ABC transporter signature motif; other site 1306400008116 Walker B; other site 1306400008117 D-loop; other site 1306400008118 H-loop/switch region; other site 1306400008119 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1306400008120 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1306400008121 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1306400008122 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1306400008123 acyltransferase PapA5; Provisional; Region: PRK09294 1306400008124 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400008125 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400008126 active site 1306400008127 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1306400008128 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400008129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400008130 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400008131 Enoylreductase; Region: PKS_ER; smart00829 1306400008132 NAD(P) binding site [chemical binding]; other site 1306400008133 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306400008134 KR domain; Region: KR; pfam08659 1306400008135 putative NADP binding site [chemical binding]; other site 1306400008136 active site 1306400008137 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400008138 acyl-CoA synthetase; Validated; Region: PRK05850 1306400008139 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400008140 acyl-activating enzyme (AAE) consensus motif; other site 1306400008141 active site 1306400008142 MMPL family; Region: MMPL; pfam03176 1306400008143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1306400008144 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1306400008145 Integrase core domain; Region: rve; pfam00665 1306400008146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1306400008147 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1306400008148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400008149 ATP binding site [chemical binding]; other site 1306400008150 Walker A motif; other site 1306400008151 Walker B motif; other site 1306400008152 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1306400008153 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306400008154 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400008155 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400008156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400008157 Enoylreductase; Region: PKS_ER; smart00829 1306400008158 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400008159 NAD(P) binding site [chemical binding]; other site 1306400008160 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1306400008161 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1306400008162 putative NADP binding site [chemical binding]; other site 1306400008163 active site 1306400008164 Erythronolide synthase docking; Region: Docking; pfam08990 1306400008165 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400008166 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1306400008167 active site 1306400008168 acyl-CoA synthetase; Validated; Region: PRK06060 1306400008169 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1306400008170 dimer interface [polypeptide binding]; other site 1306400008171 acyl-activating enzyme (AAE) consensus motif; other site 1306400008172 putative active site [active] 1306400008173 putative AMP binding site [chemical binding]; other site 1306400008174 putative CoA binding site [chemical binding]; other site 1306400008175 chemical substrate binding site [chemical binding]; other site 1306400008176 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400008177 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1306400008178 acyl-CoA synthetase; Validated; Region: PRK05850 1306400008179 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400008180 acyl-activating enzyme (AAE) consensus motif; other site 1306400008181 active site 1306400008182 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1306400008183 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400008184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400008185 S-adenosylmethionine binding site [chemical binding]; other site 1306400008186 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1306400008187 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400008188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400008189 S-adenosylmethionine binding site [chemical binding]; other site 1306400008190 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1306400008191 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1306400008192 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1306400008193 metal-binding site 1306400008194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400008195 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306400008196 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1306400008197 active site 1306400008198 TDP-binding site; other site 1306400008199 acceptor substrate-binding pocket; other site 1306400008200 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1306400008201 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1306400008202 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1306400008203 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1306400008204 active site 1306400008205 TDP-binding site; other site 1306400008206 acceptor substrate-binding pocket; other site 1306400008207 Predicted permease; Region: DUF318; pfam03773 1306400008208 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1306400008209 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1306400008210 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1306400008211 putative active site [active] 1306400008212 putative substrate binding site [chemical binding]; other site 1306400008213 putative cosubstrate binding site; other site 1306400008214 catalytic site [active] 1306400008215 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1306400008216 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1306400008217 active site 1306400008218 (T/H)XGH motif; other site 1306400008219 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1306400008220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400008221 S-adenosylmethionine binding site [chemical binding]; other site 1306400008222 pyruvate carboxylase; Reviewed; Region: PRK12999 1306400008223 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306400008224 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1306400008225 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1306400008226 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1306400008227 active site 1306400008228 catalytic residues [active] 1306400008229 metal binding site [ion binding]; metal-binding site 1306400008230 homodimer binding site [polypeptide binding]; other site 1306400008231 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306400008232 carboxyltransferase (CT) interaction site; other site 1306400008233 biotinylation site [posttranslational modification]; other site 1306400008234 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1306400008235 putative active site [active] 1306400008236 redox center [active] 1306400008237 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1306400008238 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1306400008239 catalytic residues [active] 1306400008240 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1306400008241 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400008242 substrate binding pocket [chemical binding]; other site 1306400008243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1306400008244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1306400008245 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1306400008246 active site 1306400008247 catalytic tetrad [active] 1306400008248 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1306400008249 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1306400008250 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1306400008251 generic binding surface II; other site 1306400008252 ssDNA binding site; other site 1306400008253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306400008254 ATP binding site [chemical binding]; other site 1306400008255 putative Mg++ binding site [ion binding]; other site 1306400008256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400008257 nucleotide binding region [chemical binding]; other site 1306400008258 ATP-binding site [chemical binding]; other site 1306400008259 DAK2 domain; Region: Dak2; cl03685 1306400008260 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1306400008261 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1306400008262 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1306400008263 ligand binding site [chemical binding]; other site 1306400008264 active site 1306400008265 UGI interface [polypeptide binding]; other site 1306400008266 catalytic site [active] 1306400008267 thiamine monophosphate kinase; Provisional; Region: PRK05731 1306400008268 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1306400008269 ATP binding site [chemical binding]; other site 1306400008270 dimerization interface [polypeptide binding]; other site 1306400008271 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306400008272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306400008273 Probable transposase; Region: OrfB_IS605; pfam01385 1306400008274 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306400008275 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1306400008276 catalytic residues [active] 1306400008277 catalytic nucleophile [active] 1306400008278 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1306400008279 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1306400008280 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1306400008281 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1306400008282 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1306400008283 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1306400008284 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1306400008285 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1306400008286 polyphosphate kinase; Provisional; Region: PRK05443 1306400008287 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1306400008288 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1306400008289 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1306400008290 putative domain interface [polypeptide binding]; other site 1306400008291 putative active site [active] 1306400008292 catalytic site [active] 1306400008293 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1306400008294 putative domain interface [polypeptide binding]; other site 1306400008295 putative active site [active] 1306400008296 catalytic site [active] 1306400008297 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1306400008298 active site 1306400008299 Ap6A binding site [chemical binding]; other site 1306400008300 nudix motif; other site 1306400008301 metal binding site [ion binding]; metal-binding site 1306400008302 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400008303 catalytic core [active] 1306400008304 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1306400008305 IHF - DNA interface [nucleotide binding]; other site 1306400008306 IHF dimer interface [polypeptide binding]; other site 1306400008307 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1306400008308 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1306400008309 substrate binding site [chemical binding]; other site 1306400008310 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1306400008311 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1306400008312 substrate binding site [chemical binding]; other site 1306400008313 ligand binding site [chemical binding]; other site 1306400008314 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1306400008315 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1306400008316 Bacterial transcriptional regulator; Region: IclR; pfam01614 1306400008317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400008318 S-adenosylmethionine binding site [chemical binding]; other site 1306400008319 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1306400008320 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1306400008321 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1306400008322 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306400008323 active site 1306400008324 HIGH motif; other site 1306400008325 nucleotide binding site [chemical binding]; other site 1306400008326 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1306400008327 active site 1306400008328 KMSKS motif; other site 1306400008329 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1306400008330 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1306400008331 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1306400008332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400008333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1306400008334 putative substrate translocation pore; other site 1306400008335 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1306400008336 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1306400008337 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1306400008338 ligand binding site [chemical binding]; other site 1306400008339 NAD binding site [chemical binding]; other site 1306400008340 dimerization interface [polypeptide binding]; other site 1306400008341 catalytic site [active] 1306400008342 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1306400008343 putative L-serine binding site [chemical binding]; other site 1306400008344 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1306400008345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400008346 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1306400008347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1306400008348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1306400008349 phosphorylation site [posttranslational modification] 1306400008350 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1306400008351 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1306400008352 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1306400008353 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1306400008354 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1306400008355 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1306400008356 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1306400008357 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1306400008358 putative valine binding site [chemical binding]; other site 1306400008359 dimer interface [polypeptide binding]; other site 1306400008360 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1306400008361 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1306400008362 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306400008363 PYR/PP interface [polypeptide binding]; other site 1306400008364 dimer interface [polypeptide binding]; other site 1306400008365 TPP binding site [chemical binding]; other site 1306400008366 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306400008367 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1306400008368 TPP-binding site [chemical binding]; other site 1306400008369 dimer interface [polypeptide binding]; other site 1306400008370 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1306400008371 Predicted membrane protein [Function unknown]; Region: COG2259 1306400008372 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1306400008373 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1306400008374 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1306400008375 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1306400008376 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1306400008377 GatB domain; Region: GatB_Yqey; smart00845 1306400008378 6-phosphofructokinase; Provisional; Region: PRK03202 1306400008379 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1306400008380 active site 1306400008381 ADP/pyrophosphate binding site [chemical binding]; other site 1306400008382 dimerization interface [polypeptide binding]; other site 1306400008383 allosteric effector site; other site 1306400008384 fructose-1,6-bisphosphate binding site; other site 1306400008385 potential frameshift: common BLAST hit: gi|471339041|ref|YP_007611754.1| aspartyl/glutamyl-tRNA amidotransferase subunitA 1306400008386 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1306400008387 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1306400008388 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1306400008389 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1306400008390 nucleotide binding pocket [chemical binding]; other site 1306400008391 K-X-D-G motif; other site 1306400008392 catalytic site [active] 1306400008393 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1306400008394 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1306400008395 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1306400008396 Dimer interface [polypeptide binding]; other site 1306400008397 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1306400008398 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306400008399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306400008400 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400008401 PPE family; Region: PPE; pfam00823 1306400008402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306400008403 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400008404 PPE family; Region: PPE; pfam00823 1306400008405 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400008406 MULE transposase domain; Region: MULE; pfam10551 1306400008407 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1306400008408 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1306400008409 Ligand Binding Site [chemical binding]; other site 1306400008410 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1306400008411 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1306400008412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400008413 catalytic residue [active] 1306400008414 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400008415 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306400008416 putative acyl-acceptor binding pocket; other site 1306400008417 Putative hemolysin [General function prediction only]; Region: COG3176 1306400008418 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1306400008419 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1306400008420 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1306400008421 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1306400008422 Ligand binding site [chemical binding]; other site 1306400008423 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1306400008424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400008425 S-adenosylmethionine binding site [chemical binding]; other site 1306400008426 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1306400008427 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1306400008428 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1306400008429 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1306400008430 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1306400008431 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1306400008432 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1306400008433 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1306400008434 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1306400008435 trimer interface [polypeptide binding]; other site 1306400008436 active site 1306400008437 substrate binding site [chemical binding]; other site 1306400008438 CoA binding site [chemical binding]; other site 1306400008439 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1306400008440 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1306400008441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400008442 S-adenosylmethionine binding site [chemical binding]; other site 1306400008443 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400008444 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1306400008445 substrate binding site [chemical binding]; other site 1306400008446 oxyanion hole (OAH) forming residues; other site 1306400008447 trimer interface [polypeptide binding]; other site 1306400008448 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1306400008449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400008450 Walker A/P-loop; other site 1306400008451 ATP binding site [chemical binding]; other site 1306400008452 Q-loop/lid; other site 1306400008453 ABC transporter signature motif; other site 1306400008454 Walker B; other site 1306400008455 D-loop; other site 1306400008456 H-loop/switch region; other site 1306400008457 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1306400008458 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1306400008459 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1306400008460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400008461 motif II; other site 1306400008462 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1306400008463 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1306400008464 D-pathway; other site 1306400008465 Putative ubiquinol binding site [chemical binding]; other site 1306400008466 Low-spin heme (heme b) binding site [chemical binding]; other site 1306400008467 Putative water exit pathway; other site 1306400008468 Binuclear center (heme o3/CuB) [ion binding]; other site 1306400008469 K-pathway; other site 1306400008470 Putative proton exit pathway; other site 1306400008471 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1306400008472 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1306400008473 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1306400008474 siderophore binding site; other site 1306400008475 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1306400008476 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1306400008477 putative NAD(P) binding site [chemical binding]; other site 1306400008478 putative substrate binding site [chemical binding]; other site 1306400008479 catalytic Zn binding site [ion binding]; other site 1306400008480 structural Zn binding site [ion binding]; other site 1306400008481 dimer interface [polypeptide binding]; other site 1306400008482 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1306400008483 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1306400008484 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1306400008485 dimer interface [polypeptide binding]; other site 1306400008486 putative radical transfer pathway; other site 1306400008487 diiron center [ion binding]; other site 1306400008488 tyrosyl radical; other site 1306400008489 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400008490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306400008491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400008492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400008493 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1306400008494 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1306400008495 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1306400008496 active site 1306400008497 dimer interface [polypeptide binding]; other site 1306400008498 catalytic residues [active] 1306400008499 effector binding site; other site 1306400008500 R2 peptide binding site; other site 1306400008501 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1306400008502 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1306400008503 catalytic residues [active] 1306400008504 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1306400008505 Predicted flavoprotein [General function prediction only]; Region: COG0431 1306400008506 DNA polymerase IV; Validated; Region: PRK03352 1306400008507 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1306400008508 active site 1306400008509 DNA binding site [nucleotide binding] 1306400008510 short chain dehydrogenase; Provisional; Region: PRK07832 1306400008511 classical (c) SDRs; Region: SDR_c; cd05233 1306400008512 NAD(P) binding site [chemical binding]; other site 1306400008513 active site 1306400008514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400008515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400008516 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400008517 Cytochrome P450; Region: p450; cl12078 1306400008518 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306400008519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306400008520 DNA-binding site [nucleotide binding]; DNA binding site 1306400008521 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1306400008522 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1306400008523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1306400008524 DNA-binding site [nucleotide binding]; DNA binding site 1306400008525 FCD domain; Region: FCD; pfam07729 1306400008526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400008527 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306400008528 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400008529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400008530 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400008531 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400008532 active site 1306400008533 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1306400008534 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1306400008535 active site 1306400008536 DNA binding site [nucleotide binding] 1306400008537 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1306400008538 DNA binding site [nucleotide binding] 1306400008539 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1306400008540 Carbon starvation protein CstA; Region: CstA; pfam02554 1306400008541 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1306400008542 Predicted membrane protein [Function unknown]; Region: COG2259 1306400008543 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1306400008544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1306400008545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400008546 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400008547 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1306400008548 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1306400008549 active site 1306400008550 substrate binding site [chemical binding]; other site 1306400008551 metal binding site [ion binding]; metal-binding site 1306400008552 camphor resistance protein CrcB; Provisional; Region: PRK14216 1306400008553 camphor resistance protein CrcB; Provisional; Region: PRK14228 1306400008554 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1306400008555 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1306400008556 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1306400008557 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400008558 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1306400008559 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400008560 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1306400008561 active site 1306400008562 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1306400008563 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1306400008564 putative hydrophobic ligand binding site [chemical binding]; other site 1306400008565 protein interface [polypeptide binding]; other site 1306400008566 gate; other site 1306400008567 potential frameshift: common BLAST hit: gi|449065168|ref|YP_007432251.1| hydrolase 1306400008568 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1306400008569 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400008570 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1306400008571 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1306400008572 active site 1306400008573 ATP binding site [chemical binding]; other site 1306400008574 substrate binding site [chemical binding]; other site 1306400008575 activation loop (A-loop); other site 1306400008576 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1306400008577 AAA ATPase domain; Region: AAA_16; pfam13191 1306400008578 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1306400008579 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1306400008580 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306400008581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306400008582 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400008583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306400008584 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1306400008585 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1306400008586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400008587 NAD(P) binding site [chemical binding]; other site 1306400008588 active site 1306400008589 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1306400008590 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1306400008591 NAD binding site [chemical binding]; other site 1306400008592 catalytic Zn binding site [ion binding]; other site 1306400008593 substrate binding site [chemical binding]; other site 1306400008594 structural Zn binding site [ion binding]; other site 1306400008595 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400008596 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400008597 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400008598 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400008599 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1306400008600 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1306400008601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400008602 acyl-activating enzyme (AAE) consensus motif; other site 1306400008603 AMP binding site [chemical binding]; other site 1306400008604 active site 1306400008605 CoA binding site [chemical binding]; other site 1306400008606 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1306400008607 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1306400008608 Patatin-like phospholipase; Region: Patatin; pfam01734 1306400008609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1306400008610 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1306400008611 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400008612 Predicted transcriptional regulators [Transcription]; Region: COG1733 1306400008613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400008614 dimerization interface [polypeptide binding]; other site 1306400008615 putative DNA binding site [nucleotide binding]; other site 1306400008616 putative Zn2+ binding site [ion binding]; other site 1306400008617 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1306400008618 PE family; Region: PE; pfam00934 1306400008619 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400008620 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1306400008621 De-etiolated protein 1 Det1; Region: Det1; pfam09737 1306400008622 PemK-like protein; Region: PemK; pfam02452 1306400008623 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306400008624 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1306400008625 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1306400008626 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1306400008627 SmpB-tmRNA interface; other site 1306400008628 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1306400008629 FtsX-like permease family; Region: FtsX; pfam02687 1306400008630 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1306400008631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1306400008632 Walker A/P-loop; other site 1306400008633 ATP binding site [chemical binding]; other site 1306400008634 Q-loop/lid; other site 1306400008635 ABC transporter signature motif; other site 1306400008636 Walker B; other site 1306400008637 D-loop; other site 1306400008638 H-loop/switch region; other site 1306400008639 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1306400008640 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1306400008641 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1306400008642 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1306400008643 RF-1 domain; Region: RF-1; pfam00472 1306400008644 ferredoxin-NADP+ reductase; Region: PLN02852 1306400008645 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400008646 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400008647 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1306400008648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400008649 FeS/SAM binding site; other site 1306400008650 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1306400008651 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1306400008652 aromatic arch; other site 1306400008653 DCoH dimer interaction site [polypeptide binding]; other site 1306400008654 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1306400008655 DCoH tetramer interaction site [polypeptide binding]; other site 1306400008656 substrate binding site [chemical binding]; other site 1306400008657 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1306400008658 trimer interface [polypeptide binding]; other site 1306400008659 dimer interface [polypeptide binding]; other site 1306400008660 putative active site [active] 1306400008661 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1306400008662 MoaE interaction surface [polypeptide binding]; other site 1306400008663 MoeB interaction surface [polypeptide binding]; other site 1306400008664 thiocarboxylated glycine; other site 1306400008665 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1306400008666 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1306400008667 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1306400008668 nucleoside/Zn binding site; other site 1306400008669 dimer interface [polypeptide binding]; other site 1306400008670 catalytic motif [active] 1306400008671 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400008672 MULE transposase domain; Region: MULE; pfam10551 1306400008673 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1306400008674 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1306400008675 ATP binding site [chemical binding]; other site 1306400008676 substrate interface [chemical binding]; other site 1306400008677 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1306400008678 active site residue [active] 1306400008679 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1306400008680 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1306400008681 active site residue [active] 1306400008682 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1306400008683 active site residue [active] 1306400008684 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1306400008685 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1306400008686 MoaE homodimer interface [polypeptide binding]; other site 1306400008687 MoaD interaction [polypeptide binding]; other site 1306400008688 active site residues [active] 1306400008689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400008690 S-adenosylmethionine binding site [chemical binding]; other site 1306400008691 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400008692 Cytochrome P450; Region: p450; cl12078 1306400008693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1306400008694 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1306400008695 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1306400008696 DNA binding site [nucleotide binding] 1306400008697 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400008698 PPE family; Region: PPE; pfam00823 1306400008699 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306400008700 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1306400008701 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400008702 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400008703 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306400008704 dimer interface [polypeptide binding]; other site 1306400008705 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1306400008706 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1306400008707 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1306400008708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1306400008709 Histidine kinase; Region: HisKA_3; pfam07730 1306400008710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400008711 ATP binding site [chemical binding]; other site 1306400008712 Mg2+ binding site [ion binding]; other site 1306400008713 G-X-G motif; other site 1306400008714 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1306400008715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400008716 active site 1306400008717 phosphorylation site [posttranslational modification] 1306400008718 intermolecular recognition site; other site 1306400008719 dimerization interface [polypeptide binding]; other site 1306400008720 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1306400008721 DNA binding residues [nucleotide binding] 1306400008722 dimerization interface [polypeptide binding]; other site 1306400008723 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1306400008724 Ligand Binding Site [chemical binding]; other site 1306400008725 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400008726 PPE family; Region: PPE; pfam00823 1306400008727 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400008728 PPE family; Region: PPE; pfam00823 1306400008729 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400008730 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1306400008731 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1306400008732 active site 1306400008733 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1306400008734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400008735 FeS/SAM binding site; other site 1306400008736 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400008737 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400008738 active site 1306400008739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400008740 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400008741 active site 1306400008742 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1306400008743 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1306400008744 NAD(P) binding site [chemical binding]; other site 1306400008745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400008746 active site 1306400008747 phosphorylation site [posttranslational modification] 1306400008748 intermolecular recognition site; other site 1306400008749 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400008750 PPE family; Region: PPE; pfam00823 1306400008751 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1306400008752 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1306400008753 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1306400008754 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1306400008755 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1306400008756 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1306400008757 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1306400008758 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1306400008759 putative dimer interface [polypeptide binding]; other site 1306400008760 [2Fe-2S] cluster binding site [ion binding]; other site 1306400008761 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1306400008762 SLBB domain; Region: SLBB; pfam10531 1306400008763 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1306400008764 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1306400008765 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306400008766 catalytic loop [active] 1306400008767 iron binding site [ion binding]; other site 1306400008768 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1306400008769 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1306400008770 molybdopterin cofactor binding site; other site 1306400008771 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1306400008772 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1306400008773 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1306400008774 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1306400008775 4Fe-4S binding domain; Region: Fer4; pfam00037 1306400008776 4Fe-4S binding domain; Region: Fer4; pfam00037 1306400008777 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1306400008778 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1306400008779 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1306400008780 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1306400008781 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306400008782 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1306400008783 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306400008784 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1306400008785 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1306400008786 potential frameshift: common BLAST hit: gi|15842735|ref|NP_337772.1| PPE family protein 1306400008787 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1306400008788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400008789 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1306400008790 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1306400008791 [2Fe-2S] cluster binding site [ion binding]; other site 1306400008792 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1306400008793 putative alpha subunit interface [polypeptide binding]; other site 1306400008794 putative active site [active] 1306400008795 putative substrate binding site [chemical binding]; other site 1306400008796 Fe binding site [ion binding]; other site 1306400008797 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1306400008798 Protein of unknown function DUF58; Region: DUF58; pfam01882 1306400008799 MoxR-like ATPases [General function prediction only]; Region: COG0714 1306400008800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400008801 Walker A motif; other site 1306400008802 ATP binding site [chemical binding]; other site 1306400008803 Walker B motif; other site 1306400008804 arginine finger; other site 1306400008805 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1306400008806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400008807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400008808 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1306400008809 putative active site [active] 1306400008810 putative substrate binding site [chemical binding]; other site 1306400008811 ATP binding site [chemical binding]; other site 1306400008812 Phosphotransferase enzyme family; Region: APH; pfam01636 1306400008813 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1306400008814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400008815 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1306400008816 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400008817 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306400008818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400008819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400008820 short chain dehydrogenase; Validated; Region: PRK08264 1306400008821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400008822 NAD(P) binding site [chemical binding]; other site 1306400008823 active site 1306400008824 amidase; Provisional; Region: PRK06170 1306400008825 Amidase; Region: Amidase; pfam01425 1306400008826 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400008827 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400008828 TAP-like protein; Region: Abhydrolase_4; pfam08386 1306400008829 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306400008830 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1306400008831 AAA domain; Region: AAA_14; pfam13173 1306400008832 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1306400008833 putative active site [active] 1306400008834 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400008835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1306400008836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1306400008837 non-specific DNA binding site [nucleotide binding]; other site 1306400008838 salt bridge; other site 1306400008839 sequence-specific DNA binding site [nucleotide binding]; other site 1306400008840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400008841 Transposase; Region: HTH_Tnp_1; cl17663 1306400008842 putative transposase OrfB; Reviewed; Region: PHA02517 1306400008843 HTH-like domain; Region: HTH_21; pfam13276 1306400008844 Integrase core domain; Region: rve; pfam00665 1306400008845 Integrase core domain; Region: rve_3; pfam13683 1306400008846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400008847 Transposase; Region: HTH_Tnp_1; cl17663 1306400008848 putative transposase OrfB; Reviewed; Region: PHA02517 1306400008849 HTH-like domain; Region: HTH_21; pfam13276 1306400008850 Integrase core domain; Region: rve; pfam00665 1306400008851 Integrase core domain; Region: rve_3; pfam13683 1306400008852 RES domain; Region: RES; pfam08808 1306400008853 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1306400008854 Helix-turn-helix domain; Region: HTH_38; pfam13936 1306400008855 Integrase core domain; Region: rve; pfam00665 1306400008856 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1306400008857 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400008858 hypothetical protein; Validated; Region: PRK00068 1306400008859 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1306400008860 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1306400008861 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1306400008862 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1306400008863 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1306400008864 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1306400008865 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1306400008866 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1306400008867 ABC1 family; Region: ABC1; pfam03109 1306400008868 Phosphotransferase enzyme family; Region: APH; pfam01636 1306400008869 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1306400008870 active site 1306400008871 ATP binding site [chemical binding]; other site 1306400008872 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1306400008873 Part of AAA domain; Region: AAA_19; pfam13245 1306400008874 Family description; Region: UvrD_C_2; pfam13538 1306400008875 HRDC domain; Region: HRDC; pfam00570 1306400008876 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1306400008877 catalytic residues [active] 1306400008878 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1306400008879 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1306400008880 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1306400008881 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1306400008882 putative NADH binding site [chemical binding]; other site 1306400008883 putative active site [active] 1306400008884 nudix motif; other site 1306400008885 putative metal binding site [ion binding]; other site 1306400008886 Ion channel; Region: Ion_trans_2; pfam07885 1306400008887 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1306400008888 TrkA-N domain; Region: TrkA_N; pfam02254 1306400008889 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1306400008890 Part of AAA domain; Region: AAA_19; pfam13245 1306400008891 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1306400008892 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1306400008893 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1306400008894 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1306400008895 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1306400008896 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1306400008897 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1306400008898 active site 1306400008899 DNA binding site [nucleotide binding] 1306400008900 TIGR02569 family protein; Region: TIGR02569_actnb 1306400008901 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1306400008902 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1306400008903 ATP binding site [chemical binding]; other site 1306400008904 substrate interface [chemical binding]; other site 1306400008905 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1306400008906 active site residue [active] 1306400008907 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1306400008908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400008909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400008910 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1306400008911 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1306400008912 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1306400008913 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1306400008914 ATP binding site [chemical binding]; other site 1306400008915 Mg++ binding site [ion binding]; other site 1306400008916 motif III; other site 1306400008917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400008918 nucleotide binding region [chemical binding]; other site 1306400008919 ATP-binding site [chemical binding]; other site 1306400008920 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1306400008921 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306400008922 P-loop; other site 1306400008923 Magnesium ion binding site [ion binding]; other site 1306400008924 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306400008925 Magnesium ion binding site [ion binding]; other site 1306400008926 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400008927 catalytic core [active] 1306400008928 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1306400008929 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1306400008930 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1306400008931 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1306400008932 Transcription factor WhiB; Region: Whib; pfam02467 1306400008933 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1306400008934 PAS domain S-box; Region: sensory_box; TIGR00229 1306400008935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1306400008936 Histidine kinase; Region: HisKA_2; pfam07568 1306400008937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400008938 ATP binding site [chemical binding]; other site 1306400008939 Mg2+ binding site [ion binding]; other site 1306400008940 G-X-G motif; other site 1306400008941 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306400008942 carboxyltransferase (CT) interaction site; other site 1306400008943 biotinylation site [posttranslational modification]; other site 1306400008944 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1306400008945 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1306400008946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400008947 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400008948 DNA binding residues [nucleotide binding] 1306400008949 short chain dehydrogenase; Provisional; Region: PRK08278 1306400008950 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1306400008951 NAD(P) binding site [chemical binding]; other site 1306400008952 homodimer interface [polypeptide binding]; other site 1306400008953 active site 1306400008954 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1306400008955 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1306400008956 putative deacylase active site [active] 1306400008957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1306400008958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1306400008959 Coenzyme A binding pocket [chemical binding]; other site 1306400008960 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1306400008961 Phosphotransferase enzyme family; Region: APH; pfam01636 1306400008962 putative active site [active] 1306400008963 putative substrate binding site [chemical binding]; other site 1306400008964 ATP binding site [chemical binding]; other site 1306400008965 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1306400008966 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1306400008967 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1306400008968 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1306400008969 hinge; other site 1306400008970 active site 1306400008971 Predicted GTPases [General function prediction only]; Region: COG1162 1306400008972 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1306400008973 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1306400008974 GTP/Mg2+ binding site [chemical binding]; other site 1306400008975 G4 box; other site 1306400008976 G5 box; other site 1306400008977 G1 box; other site 1306400008978 Switch I region; other site 1306400008979 G2 box; other site 1306400008980 G3 box; other site 1306400008981 Switch II region; other site 1306400008982 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1306400008983 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1306400008984 putative di-iron ligands [ion binding]; other site 1306400008985 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1306400008986 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1306400008987 FAD binding pocket [chemical binding]; other site 1306400008988 FAD binding motif [chemical binding]; other site 1306400008989 phosphate binding motif [ion binding]; other site 1306400008990 beta-alpha-beta structure motif; other site 1306400008991 NAD binding pocket [chemical binding]; other site 1306400008992 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306400008993 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1306400008994 catalytic loop [active] 1306400008995 iron binding site [ion binding]; other site 1306400008996 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1306400008997 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400008998 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400008999 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1306400009000 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1306400009001 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1306400009002 TrkA-C domain; Region: TrkA_C; pfam02080 1306400009003 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1306400009004 potential frameshift: common BLAST hit: gi|449065343|ref|YP_007432426.1| conserved membrane transporter 1306400009005 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 1306400009006 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1306400009007 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 1306400009008 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1306400009009 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1306400009010 30S subunit binding site; other site 1306400009011 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1306400009012 active site 1306400009013 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1306400009014 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1306400009015 lipoprotein LpqB; Provisional; Region: PRK13616 1306400009016 Sporulation and spore germination; Region: Germane; pfam10646 1306400009017 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1306400009018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400009019 dimerization interface [polypeptide binding]; other site 1306400009020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306400009021 dimer interface [polypeptide binding]; other site 1306400009022 phosphorylation site [posttranslational modification] 1306400009023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400009024 ATP binding site [chemical binding]; other site 1306400009025 Mg2+ binding site [ion binding]; other site 1306400009026 G-X-G motif; other site 1306400009027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400009028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400009029 active site 1306400009030 phosphorylation site [posttranslational modification] 1306400009031 intermolecular recognition site; other site 1306400009032 dimerization interface [polypeptide binding]; other site 1306400009033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400009034 DNA binding site [nucleotide binding] 1306400009035 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1306400009036 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1306400009037 TMP-binding site; other site 1306400009038 ATP-binding site [chemical binding]; other site 1306400009039 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1306400009040 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1306400009041 homotetramer interface [polypeptide binding]; other site 1306400009042 ligand binding site [chemical binding]; other site 1306400009043 catalytic site [active] 1306400009044 NAD binding site [chemical binding]; other site 1306400009045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400009046 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1306400009047 Rubredoxin [Energy production and conversion]; Region: COG1773 1306400009048 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1306400009049 iron binding site [ion binding]; other site 1306400009050 Rubredoxin [Energy production and conversion]; Region: COG1773 1306400009051 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1306400009052 iron binding site [ion binding]; other site 1306400009053 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1306400009054 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1306400009055 Di-iron ligands [ion binding]; other site 1306400009056 amino acid transporter; Region: 2A0306; TIGR00909 1306400009057 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1306400009058 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1306400009059 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1306400009060 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1306400009061 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1306400009062 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1306400009063 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1306400009064 active site 1306400009065 substrate binding site [chemical binding]; other site 1306400009066 metal binding site [ion binding]; metal-binding site 1306400009067 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1306400009068 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1306400009069 Transcription factor WhiB; Region: Whib; pfam02467 1306400009070 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1306400009071 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1306400009072 phosphate binding site [ion binding]; other site 1306400009073 dimer interface [polypeptide binding]; other site 1306400009074 substrate binding site [chemical binding]; other site 1306400009075 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1306400009076 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1306400009077 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1306400009078 putative FMN binding site [chemical binding]; other site 1306400009079 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1306400009080 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1306400009081 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1306400009082 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1306400009083 active site 1306400009084 Substrate binding site; other site 1306400009085 Mg++ binding site; other site 1306400009086 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1306400009087 potential frameshift: common BLAST hit: gi|471339319|ref|YP_007612032.1| dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenolA-3-L-rhamnosyl 1306400009088 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1306400009089 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1306400009090 NADP binding site [chemical binding]; other site 1306400009091 active site 1306400009092 putative substrate binding site [chemical binding]; other site 1306400009093 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1306400009094 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306400009095 TIGR03089 family protein; Region: TIGR03089 1306400009096 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1306400009097 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1306400009098 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400009099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1306400009100 active site 1306400009101 motif I; other site 1306400009102 motif II; other site 1306400009103 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1306400009104 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1306400009105 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1306400009106 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1306400009107 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1306400009108 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1306400009109 active site clefts [active] 1306400009110 zinc binding site [ion binding]; other site 1306400009111 dimer interface [polypeptide binding]; other site 1306400009112 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009113 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1306400009114 FAD binding site [chemical binding]; other site 1306400009115 homotetramer interface [polypeptide binding]; other site 1306400009116 substrate binding pocket [chemical binding]; other site 1306400009117 catalytic base [active] 1306400009118 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1306400009119 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1306400009120 ATP-grasp domain; Region: ATP-grasp; pfam02222 1306400009121 Predicted membrane protein [Function unknown]; Region: COG2246 1306400009122 GtrA-like protein; Region: GtrA; pfam04138 1306400009123 Bacterial PH domain; Region: DUF304; pfam03703 1306400009124 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1306400009125 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1306400009126 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1306400009127 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306400009128 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1306400009129 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306400009130 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1306400009131 Maf-like protein; Region: Maf; pfam02545 1306400009132 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1306400009133 active site 1306400009134 dimer interface [polypeptide binding]; other site 1306400009135 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1306400009136 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1306400009137 active site residue [active] 1306400009138 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1306400009139 active site residue [active] 1306400009140 Fe-S metabolism associated domain; Region: SufE; pfam02657 1306400009141 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1306400009142 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1306400009143 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1306400009144 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1306400009145 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1306400009146 carboxyltransferase (CT) interaction site; other site 1306400009147 biotinylation site [posttranslational modification]; other site 1306400009148 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1306400009149 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400009150 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1306400009151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1306400009152 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1306400009153 L-lysine aminotransferase; Provisional; Region: PRK08297 1306400009154 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306400009155 inhibitor-cofactor binding pocket; inhibition site 1306400009156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400009157 catalytic residue [active] 1306400009158 putative DNA binding site [nucleotide binding]; other site 1306400009159 dimerization interface [polypeptide binding]; other site 1306400009160 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1306400009161 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1306400009162 putative Zn2+ binding site [ion binding]; other site 1306400009163 AsnC family; Region: AsnC_trans_reg; pfam01037 1306400009164 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1306400009165 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1306400009166 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1306400009167 tetrameric interface [polypeptide binding]; other site 1306400009168 NAD binding site [chemical binding]; other site 1306400009169 catalytic residues [active] 1306400009170 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1306400009171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400009172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400009173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306400009174 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1306400009175 ATP binding site [chemical binding]; other site 1306400009176 putative Mg++ binding site [ion binding]; other site 1306400009177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400009178 nucleotide binding region [chemical binding]; other site 1306400009179 ATP-binding site [chemical binding]; other site 1306400009180 DEAD/H associated; Region: DEAD_assoc; pfam08494 1306400009181 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1306400009182 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1306400009183 putative DNA binding site [nucleotide binding]; other site 1306400009184 catalytic residue [active] 1306400009185 putative H2TH interface [polypeptide binding]; other site 1306400009186 putative catalytic residues [active] 1306400009187 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1306400009188 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1306400009189 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1306400009190 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1306400009191 Sulfatase; Region: Sulfatase; pfam00884 1306400009192 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1306400009193 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1306400009194 probable active site [active] 1306400009195 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1306400009196 PhoU domain; Region: PhoU; pfam01895 1306400009197 PhoU domain; Region: PhoU; pfam01895 1306400009198 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1306400009199 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1306400009200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400009201 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1306400009202 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1306400009203 putative active site pocket [active] 1306400009204 dimerization interface [polypeptide binding]; other site 1306400009205 putative catalytic residue [active] 1306400009206 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1306400009207 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1306400009208 metal binding site [ion binding]; metal-binding site 1306400009209 putative dimer interface [polypeptide binding]; other site 1306400009210 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1306400009211 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1306400009212 metal binding site [ion binding]; metal-binding site 1306400009213 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1306400009214 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1306400009215 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1306400009216 active site 1306400009217 substrate binding site [chemical binding]; other site 1306400009218 metal binding site [ion binding]; metal-binding site 1306400009219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400009220 active site 1306400009221 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1306400009222 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400009223 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1306400009224 adenosine deaminase; Provisional; Region: PRK09358 1306400009225 active site 1306400009226 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1306400009227 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1306400009228 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1306400009229 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1306400009230 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1306400009231 active site 1306400009232 catalytic motif [active] 1306400009233 Zn binding site [ion binding]; other site 1306400009234 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1306400009235 putative Iron-sulfur protein interface [polypeptide binding]; other site 1306400009236 putative proximal heme binding site [chemical binding]; other site 1306400009237 putative SdhD-like interface [polypeptide binding]; other site 1306400009238 putative distal heme binding site [chemical binding]; other site 1306400009239 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1306400009240 putative Iron-sulfur protein interface [polypeptide binding]; other site 1306400009241 putative proximal heme binding site [chemical binding]; other site 1306400009242 putative SdhC-like subunit interface [polypeptide binding]; other site 1306400009243 putative distal heme binding site [chemical binding]; other site 1306400009244 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1306400009245 L-aspartate oxidase; Provisional; Region: PRK06175 1306400009246 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1306400009247 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1306400009248 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1306400009249 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400009250 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1306400009251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400009252 S-adenosylmethionine binding site [chemical binding]; other site 1306400009253 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1306400009254 MoaE interaction surface [polypeptide binding]; other site 1306400009255 MoeB interaction surface [polypeptide binding]; other site 1306400009256 thiocarboxylated glycine; other site 1306400009257 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1306400009258 MoaE homodimer interface [polypeptide binding]; other site 1306400009259 MoaD interaction [polypeptide binding]; other site 1306400009260 active site residues [active] 1306400009261 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1306400009262 trimer interface [polypeptide binding]; other site 1306400009263 dimer interface [polypeptide binding]; other site 1306400009264 putative active site [active] 1306400009265 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 1306400009266 substrate binding site [chemical binding]; other site 1306400009267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400009268 Transposase; Region: HTH_Tnp_1; cl17663 1306400009269 putative transposase OrfB; Reviewed; Region: PHA02517 1306400009270 HTH-like domain; Region: HTH_21; pfam13276 1306400009271 Integrase core domain; Region: rve; pfam00665 1306400009272 Integrase core domain; Region: rve_3; pfam13683 1306400009273 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306400009274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1306400009275 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306400009276 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1306400009277 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1306400009278 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1306400009279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400009280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400009281 DNA binding residues [nucleotide binding] 1306400009282 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306400009283 hypothetical protein; Provisional; Region: PRK06541 1306400009284 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1306400009285 inhibitor-cofactor binding pocket; inhibition site 1306400009286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400009287 catalytic residue [active] 1306400009288 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1306400009289 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1306400009290 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1306400009291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400009292 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1306400009293 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1306400009294 active site 1306400009295 dimer interface [polypeptide binding]; other site 1306400009296 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400009297 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1306400009298 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1306400009299 DNA binding residues [nucleotide binding] 1306400009300 dimer interface [polypeptide binding]; other site 1306400009301 metal binding site [ion binding]; metal-binding site 1306400009302 inner membrane protein YhjD; Region: TIGR00766 1306400009303 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1306400009304 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1306400009305 active site 1306400009306 HIGH motif; other site 1306400009307 dimer interface [polypeptide binding]; other site 1306400009308 KMSKS motif; other site 1306400009309 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1306400009310 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1306400009311 isocitrate dehydrogenase; Validated; Region: PRK08299 1306400009312 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1306400009313 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1306400009314 homodimer interface [polypeptide binding]; other site 1306400009315 substrate-cofactor binding pocket; other site 1306400009316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400009317 catalytic residue [active] 1306400009318 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1306400009319 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1306400009320 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400009321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400009322 S-adenosylmethionine binding site [chemical binding]; other site 1306400009323 PPE family; Region: PPE; pfam00823 1306400009324 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009325 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009326 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009327 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009328 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009329 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009330 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009331 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009332 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009333 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009334 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009335 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009336 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009337 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009338 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009339 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009340 PE family; Region: PE; pfam00934 1306400009341 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1306400009342 PPE family; Region: PPE; pfam00823 1306400009343 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009344 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009345 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009346 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009347 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009348 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009349 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009350 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009351 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009352 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009353 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009354 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306400009355 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306400009356 potential frameshift: common BLAST hit: gi|392433836|ref|YP_006474880.1| PPE family protein 1306400009357 Berberine and berberine like; Region: BBE; pfam08031 1306400009358 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400009359 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1306400009360 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1306400009361 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1306400009362 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1306400009363 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1306400009364 homodimer interface [polypeptide binding]; other site 1306400009365 NADP binding site [chemical binding]; other site 1306400009366 substrate binding site [chemical binding]; other site 1306400009367 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1306400009368 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1306400009369 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306400009370 phosphate binding site [ion binding]; other site 1306400009371 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306400009372 phosphate binding site [ion binding]; other site 1306400009373 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306400009374 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1306400009375 phosphopeptide binding site; other site 1306400009376 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1306400009377 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1306400009378 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1306400009379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1306400009380 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1306400009381 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1306400009382 G1 box; other site 1306400009383 GTP/Mg2+ binding site [chemical binding]; other site 1306400009384 G2 box; other site 1306400009385 Switch I region; other site 1306400009386 G3 box; other site 1306400009387 Switch II region; other site 1306400009388 G4 box; other site 1306400009389 G5 box; other site 1306400009390 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1306400009391 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1306400009392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306400009393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400009394 ATP binding site [chemical binding]; other site 1306400009395 Mg2+ binding site [ion binding]; other site 1306400009396 G-X-G motif; other site 1306400009397 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1306400009398 PE family; Region: PE; pfam00934 1306400009399 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1306400009400 FMN binding site [chemical binding]; other site 1306400009401 dimer interface [polypeptide binding]; other site 1306400009402 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1306400009403 potential frameshift: common BLAST hit: gi|448824810|ref|NP_217887.3| Probable DNA polymerase III (alpha chain) DnaE2 (DNA 1306400009404 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400009405 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400009406 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1306400009407 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1306400009408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400009409 active site 1306400009410 motif I; other site 1306400009411 motif II; other site 1306400009412 PE family; Region: PE; pfam00934 1306400009413 potential frameshift: common BLAST hit: gi|449065488|ref|YP_007432571.1| enoyl-CoA hydratase 1306400009414 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1306400009415 Amidase; Region: Amidase; pfam01425 1306400009416 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1306400009417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400009418 motif II; other site 1306400009419 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1306400009420 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1306400009421 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1306400009422 TPP-binding site [chemical binding]; other site 1306400009423 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1306400009424 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1306400009425 PYR/PP interface [polypeptide binding]; other site 1306400009426 dimer interface [polypeptide binding]; other site 1306400009427 TPP binding site [chemical binding]; other site 1306400009428 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1306400009429 putative transposase OrfB; Reviewed; Region: PHA02517 1306400009430 HTH-like domain; Region: HTH_21; pfam13276 1306400009431 Integrase core domain; Region: rve; pfam00665 1306400009432 Integrase core domain; Region: rve_3; pfam13683 1306400009433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400009434 Transposase; Region: HTH_Tnp_1; cl17663 1306400009435 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1306400009436 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1306400009437 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306400009438 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306400009439 substrate binding pocket [chemical binding]; other site 1306400009440 chain length determination region; other site 1306400009441 substrate-Mg2+ binding site; other site 1306400009442 catalytic residues [active] 1306400009443 aspartate-rich region 1; other site 1306400009444 active site lid residues [active] 1306400009445 aspartate-rich region 2; other site 1306400009446 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1306400009447 putative active site [active] 1306400009448 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400009449 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1306400009450 Transposase domain (DUF772); Region: DUF772; pfam05598 1306400009451 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1306400009452 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1306400009453 PE family; Region: PE; pfam00934 1306400009454 enoyl-CoA hydratase; Region: PLN02864 1306400009455 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306400009456 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306400009457 active site 2 [active] 1306400009458 active site 1 [active] 1306400009459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400009460 short chain dehydrogenase; Provisional; Region: PRK07201 1306400009461 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1306400009462 putative NAD(P) binding site [chemical binding]; other site 1306400009463 active site 1306400009464 putative substrate binding site [chemical binding]; other site 1306400009465 classical (c) SDRs; Region: SDR_c; cd05233 1306400009466 NAD(P) binding site [chemical binding]; other site 1306400009467 active site 1306400009468 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400009469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400009470 S-adenosylmethionine binding site [chemical binding]; other site 1306400009471 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1306400009472 active site 1306400009473 DNA Polymerase Y-family; Region: PolY_like; cd03468 1306400009474 DNA binding site [nucleotide binding] 1306400009475 GMP synthase; Reviewed; Region: guaA; PRK00074 1306400009476 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1306400009477 AMP/PPi binding site [chemical binding]; other site 1306400009478 candidate oxyanion hole; other site 1306400009479 catalytic triad [active] 1306400009480 potential glutamine specificity residues [chemical binding]; other site 1306400009481 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1306400009482 ATP Binding subdomain [chemical binding]; other site 1306400009483 Ligand Binding sites [chemical binding]; other site 1306400009484 Dimerization subdomain; other site 1306400009485 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1306400009486 active site lid residues [active] 1306400009487 substrate binding pocket [chemical binding]; other site 1306400009488 catalytic residues [active] 1306400009489 substrate-Mg2+ binding site; other site 1306400009490 aspartate-rich region 1; other site 1306400009491 aspartate-rich region 2; other site 1306400009492 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1306400009493 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1306400009494 substrate binding pocket [chemical binding]; other site 1306400009495 chain length determination region; other site 1306400009496 substrate-Mg2+ binding site; other site 1306400009497 catalytic residues [active] 1306400009498 aspartate-rich region 1; other site 1306400009499 active site lid residues [active] 1306400009500 aspartate-rich region 2; other site 1306400009501 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400009502 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400009503 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1306400009504 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1306400009505 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1306400009506 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1306400009507 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1306400009508 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1306400009509 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1306400009510 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1306400009511 inhibitor-cofactor binding pocket; inhibition site 1306400009512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400009513 catalytic residue [active] 1306400009514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1306400009515 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400009516 hypothetical protein; Provisional; Region: PRK07579 1306400009517 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1306400009518 active site 1306400009519 cosubstrate binding site; other site 1306400009520 substrate binding site [chemical binding]; other site 1306400009521 catalytic site [active] 1306400009522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400009523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400009524 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1306400009525 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1306400009526 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1306400009527 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1306400009528 putative active site [active] 1306400009529 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1306400009530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400009531 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1306400009532 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1306400009533 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1306400009534 phosphate binding site [ion binding]; other site 1306400009535 potential frameshift: common BLAST hit: gi|449065524|ref|YP_007432607.1| inosine 5'-monophosphate dehydrogenase 1306400009536 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1306400009537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400009538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1306400009539 DNA binding residues [nucleotide binding] 1306400009540 Transcription factor WhiB; Region: Whib; pfam02467 1306400009541 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1306400009542 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1306400009543 ring oligomerisation interface [polypeptide binding]; other site 1306400009544 ATP/Mg binding site [chemical binding]; other site 1306400009545 stacking interactions; other site 1306400009546 hinge regions; other site 1306400009547 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1306400009548 oligomerisation interface [polypeptide binding]; other site 1306400009549 mobile loop; other site 1306400009550 roof hairpin; other site 1306400009551 UGMP family protein; Validated; Region: PRK09604 1306400009552 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1306400009553 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1306400009554 Coenzyme A binding pocket [chemical binding]; other site 1306400009555 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1306400009556 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1306400009557 alanine racemase; Reviewed; Region: alr; PRK00053 1306400009558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1306400009559 active site 1306400009560 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1306400009561 dimer interface [polypeptide binding]; other site 1306400009562 substrate binding site [chemical binding]; other site 1306400009563 catalytic residues [active] 1306400009564 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009565 PPE family; Region: PPE; pfam00823 1306400009566 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009567 PPE family; Region: PPE; pfam00823 1306400009568 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009569 PPE family; Region: PPE; pfam00823 1306400009570 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1306400009571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400009572 Walker A motif; other site 1306400009573 ATP binding site [chemical binding]; other site 1306400009574 Walker B motif; other site 1306400009575 arginine finger; other site 1306400009576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1306400009577 Integrase core domain; Region: rve; pfam00665 1306400009578 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009579 PPE family; Region: PPE; pfam00823 1306400009580 Integrase core domain; Region: rve; pfam00665 1306400009581 Integrase core domain; Region: rve_3; pfam13683 1306400009582 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400009583 MULE transposase domain; Region: MULE; pfam10551 1306400009584 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1306400009585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400009586 catalytic residue [active] 1306400009587 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1306400009588 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1306400009589 putative substrate binding site [chemical binding]; other site 1306400009590 putative ATP binding site [chemical binding]; other site 1306400009591 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1306400009592 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1306400009593 glutaminase active site [active] 1306400009594 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1306400009595 dimer interface [polypeptide binding]; other site 1306400009596 active site 1306400009597 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1306400009598 dimer interface [polypeptide binding]; other site 1306400009599 active site 1306400009600 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1306400009601 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1306400009602 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1306400009603 active site 1306400009604 substrate binding site [chemical binding]; other site 1306400009605 metal binding site [ion binding]; metal-binding site 1306400009606 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1306400009607 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1306400009608 23S rRNA interface [nucleotide binding]; other site 1306400009609 L3 interface [polypeptide binding]; other site 1306400009610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306400009611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306400009612 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1306400009613 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306400009614 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400009615 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306400009616 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400009617 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400009618 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306400009619 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1306400009620 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306400009621 active site 1306400009622 catalytic residues [active] 1306400009623 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1306400009624 Cutinase; Region: Cutinase; pfam01083 1306400009625 Cutinase; Region: Cutinase; pfam01083 1306400009626 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1306400009627 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1306400009628 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1306400009629 dimerization interface 3.5A [polypeptide binding]; other site 1306400009630 active site 1306400009631 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1306400009632 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1306400009633 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1306400009634 alphaNTD - beta interaction site [polypeptide binding]; other site 1306400009635 alphaNTD homodimer interface [polypeptide binding]; other site 1306400009636 alphaNTD - beta' interaction site [polypeptide binding]; other site 1306400009637 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1306400009638 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1306400009639 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1306400009640 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1306400009641 RNA binding surface [nucleotide binding]; other site 1306400009642 30S ribosomal protein S11; Validated; Region: PRK05309 1306400009643 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1306400009644 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1306400009645 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1306400009646 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1306400009647 rRNA binding site [nucleotide binding]; other site 1306400009648 predicted 30S ribosome binding site; other site 1306400009649 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1306400009650 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1306400009651 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1306400009652 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1306400009653 NAD binding site [chemical binding]; other site 1306400009654 substrate binding site [chemical binding]; other site 1306400009655 homodimer interface [polypeptide binding]; other site 1306400009656 active site 1306400009657 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1306400009658 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1306400009659 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306400009660 extended (e) SDRs; Region: SDR_e; cd08946 1306400009661 NAD(P) binding site [chemical binding]; other site 1306400009662 active site 1306400009663 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1306400009664 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1306400009665 active site 1306400009666 catalytic residues [active] 1306400009667 metal binding site [ion binding]; metal-binding site 1306400009668 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1306400009669 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1306400009670 PYR/PP interface [polypeptide binding]; other site 1306400009671 dimer interface [polypeptide binding]; other site 1306400009672 TPP binding site [chemical binding]; other site 1306400009673 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1306400009674 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1306400009675 TPP-binding site [chemical binding]; other site 1306400009676 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1306400009677 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1306400009678 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400009679 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1306400009680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1306400009681 Transposase; Region: HTH_Tnp_1; cl17663 1306400009682 putative transposase OrfB; Reviewed; Region: PHA02517 1306400009683 HTH-like domain; Region: HTH_21; pfam13276 1306400009684 Integrase core domain; Region: rve; pfam00665 1306400009685 Integrase core domain; Region: rve_3; pfam13683 1306400009686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400009687 metabolite-proton symporter; Region: 2A0106; TIGR00883 1306400009688 putative substrate translocation pore; other site 1306400009689 PE family; Region: PE; pfam00934 1306400009690 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009691 PPE family; Region: PPE; pfam00823 1306400009692 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400009693 patatin-related protein; Region: TIGR03607 1306400009694 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400009695 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400009696 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1306400009697 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1306400009698 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1306400009699 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1306400009700 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1306400009701 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1306400009702 short chain dehydrogenase; Provisional; Region: PRK05875 1306400009703 classical (c) SDRs; Region: SDR_c; cd05233 1306400009704 NAD(P) binding site [chemical binding]; other site 1306400009705 active site 1306400009706 Predicted membrane protein [Function unknown]; Region: COG2259 1306400009707 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1306400009708 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1306400009709 Predicted transcriptional regulators [Transcription]; Region: COG1695 1306400009710 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1306400009711 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1306400009712 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1306400009713 active site 1306400009714 homotetramer interface [polypeptide binding]; other site 1306400009715 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400009716 mce related protein; Region: MCE; pfam02470 1306400009717 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400009718 mce related protein; Region: MCE; pfam02470 1306400009719 mce related protein; Region: MCE; pfam02470 1306400009720 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400009721 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306400009722 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400009723 mce related protein; Region: MCE; pfam02470 1306400009724 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400009725 mce related protein; Region: MCE; pfam02470 1306400009726 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1306400009727 mce related protein; Region: MCE; pfam02470 1306400009728 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1306400009729 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306400009730 Permease; Region: Permease; pfam02405 1306400009731 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1306400009732 Permease; Region: Permease; pfam02405 1306400009733 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1306400009734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400009735 NAD(P) binding site [chemical binding]; other site 1306400009736 active site 1306400009737 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1306400009738 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1306400009739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009740 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1306400009741 FAD binding site [chemical binding]; other site 1306400009742 substrate binding site [chemical binding]; other site 1306400009743 catalytic base [active] 1306400009744 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009746 active site 1306400009747 acyl-CoA synthetase; Validated; Region: PRK07867 1306400009748 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1306400009749 acyl-activating enzyme (AAE) consensus motif; other site 1306400009750 putative AMP binding site [chemical binding]; other site 1306400009751 putative active site [active] 1306400009752 putative CoA binding site [chemical binding]; other site 1306400009753 PE family; Region: PE; pfam00934 1306400009754 PE family; Region: PE; pfam00934 1306400009755 potential frameshift: common BLAST hit: gi|433628651|ref|YP_007262280.1| Putative acetohydroxyacid synthase IlvX (acetolactate synthase) 1306400009756 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1306400009757 PE family; Region: PE; pfam00934 1306400009758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400009759 CoA binding site [chemical binding]; other site 1306400009760 PE family; Region: PE; pfam00934 1306400009761 acyl-CoA synthetase; Validated; Region: PRK07798 1306400009762 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400009763 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1306400009764 acyl-activating enzyme (AAE) consensus motif; other site 1306400009765 acyl-activating enzyme (AAE) consensus motif; other site 1306400009766 putative AMP binding site [chemical binding]; other site 1306400009767 putative active site [active] 1306400009768 putative CoA binding site [chemical binding]; other site 1306400009769 enoyl-CoA hydratase; Provisional; Region: PRK07799 1306400009770 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400009771 substrate binding site [chemical binding]; other site 1306400009772 oxyanion hole (OAH) forming residues; other site 1306400009773 trimer interface [polypeptide binding]; other site 1306400009774 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1306400009775 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400009776 Cytochrome P450; Region: p450; cl12078 1306400009777 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1306400009778 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1306400009779 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1306400009780 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1306400009781 DUF35 OB-fold domain; Region: DUF35; pfam01796 1306400009782 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1306400009783 DUF35 OB-fold domain; Region: DUF35; pfam01796 1306400009784 lipid-transfer protein; Provisional; Region: PRK07937 1306400009785 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306400009786 active site 1306400009787 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1306400009788 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306400009789 active site 1306400009790 NHL repeat; Region: NHL; pfam01436 1306400009791 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1306400009792 NHL repeat; Region: NHL; pfam01436 1306400009793 NHL repeat; Region: NHL; pfam01436 1306400009794 NHL repeat; Region: NHL; pfam01436 1306400009795 NHL repeat; Region: NHL; pfam01436 1306400009796 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1306400009797 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1306400009798 trimer interface [polypeptide binding]; other site 1306400009799 putative metal binding site [ion binding]; other site 1306400009800 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1306400009801 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1306400009802 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1306400009803 short chain dehydrogenase; Provisional; Region: PRK07890 1306400009804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400009805 NAD(P) binding site [chemical binding]; other site 1306400009806 active site 1306400009807 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009808 PPE family; Region: PPE; pfam00823 1306400009809 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1306400009810 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009811 PPE family; Region: PPE; pfam00823 1306400009812 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009813 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1306400009814 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1306400009815 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1306400009816 active site 1306400009817 catalytic residues [active] 1306400009818 metal binding site [ion binding]; metal-binding site 1306400009819 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1306400009820 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1306400009821 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1306400009822 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1306400009823 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1306400009824 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1306400009825 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1306400009826 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1306400009827 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1306400009828 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009829 PPE family; Region: PPE; pfam00823 1306400009830 PE-PPE domain; Region: PE-PPE; pfam08237 1306400009831 lipid-transfer protein; Provisional; Region: PRK07855 1306400009832 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1306400009833 active site 1306400009834 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1306400009835 putative active site [active] 1306400009836 putative catalytic site [active] 1306400009837 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1306400009838 active site 1306400009839 catalytic site [active] 1306400009840 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1306400009841 DUF35 OB-fold domain; Region: DUF35; pfam01796 1306400009842 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009843 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009844 active site 1306400009845 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009846 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306400009847 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009848 active site 1306400009849 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400009850 Cytochrome P450; Region: p450; cl12078 1306400009851 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1306400009852 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306400009853 dimer interface [polypeptide binding]; other site 1306400009854 active site 1306400009855 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1306400009856 short chain dehydrogenase; Provisional; Region: PRK07791 1306400009857 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1306400009858 homodimer interface [polypeptide binding]; other site 1306400009859 NAD binding site [chemical binding]; other site 1306400009860 active site 1306400009861 short chain dehydrogenase; Provisional; Region: PRK07856 1306400009862 classical (c) SDRs; Region: SDR_c; cd05233 1306400009863 NAD(P) binding site [chemical binding]; other site 1306400009864 active site 1306400009865 enoyl-CoA hydratase; Provisional; Region: PRK06495 1306400009866 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400009867 substrate binding site [chemical binding]; other site 1306400009868 oxyanion hole (OAH) forming residues; other site 1306400009869 trimer interface [polypeptide binding]; other site 1306400009870 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1306400009871 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1306400009872 Nitronate monooxygenase; Region: NMO; pfam03060 1306400009873 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1306400009874 FMN binding site [chemical binding]; other site 1306400009875 substrate binding site [chemical binding]; other site 1306400009876 putative catalytic residue [active] 1306400009877 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1306400009878 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1306400009879 putative di-iron ligands [ion binding]; other site 1306400009880 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1306400009881 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1306400009882 FAD binding pocket [chemical binding]; other site 1306400009883 FAD binding motif [chemical binding]; other site 1306400009884 phosphate binding motif [ion binding]; other site 1306400009885 beta-alpha-beta structure motif; other site 1306400009886 NAD(p) ribose binding residues [chemical binding]; other site 1306400009887 NAD binding pocket [chemical binding]; other site 1306400009888 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1306400009889 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306400009890 catalytic loop [active] 1306400009891 iron binding site [ion binding]; other site 1306400009892 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1306400009893 putative active site [active] 1306400009894 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1306400009895 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1306400009896 dimer interface [polypeptide binding]; other site 1306400009897 active site 1306400009898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400009899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400009900 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400009901 PPE family; Region: PPE; pfam00823 1306400009902 potential frameshift: common BLAST hit: gi|471339640|ref|YP_007612353.1| short chain dehydrogenase 1306400009903 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009904 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009905 active site 1306400009906 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1306400009907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1306400009908 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1306400009909 acyl-activating enzyme (AAE) consensus motif; other site 1306400009910 putative AMP binding site [chemical binding]; other site 1306400009911 putative active site [active] 1306400009912 putative CoA binding site [chemical binding]; other site 1306400009913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009915 active site 1306400009916 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009917 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306400009918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009919 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009920 active site 1306400009921 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009922 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1306400009923 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009924 active site 1306400009925 aspartate aminotransferase; Provisional; Region: PRK05764 1306400009926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400009927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400009928 homodimer interface [polypeptide binding]; other site 1306400009929 catalytic residue [active] 1306400009930 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1306400009931 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1306400009932 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1306400009933 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1306400009934 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1306400009935 active site 1306400009936 Fe binding site [ion binding]; other site 1306400009937 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1306400009938 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009939 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1306400009940 Flavin binding site [chemical binding]; other site 1306400009941 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1306400009942 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1306400009943 FAD binding pocket [chemical binding]; other site 1306400009944 FAD binding motif [chemical binding]; other site 1306400009945 phosphate binding motif [ion binding]; other site 1306400009946 beta-alpha-beta structure motif; other site 1306400009947 NAD(p) ribose binding residues [chemical binding]; other site 1306400009948 NAD binding pocket [chemical binding]; other site 1306400009949 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1306400009950 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1306400009951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1306400009952 catalytic loop [active] 1306400009953 iron binding site [ion binding]; other site 1306400009954 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1306400009957 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400009958 active site 1306400009959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400009960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400009961 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1306400009962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1306400009963 DNA binding site [nucleotide binding] 1306400009964 domain linker motif; other site 1306400009965 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1306400009966 putative dimerization interface [polypeptide binding]; other site 1306400009967 putative ligand binding site [chemical binding]; other site 1306400009968 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306400009969 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1306400009970 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1306400009971 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1306400009972 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1306400009973 transmembrane helices; other site 1306400009974 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1306400009975 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1306400009976 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1306400009977 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1306400009978 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1306400009979 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1306400009980 active site 1306400009981 HIGH motif; other site 1306400009982 nucleotide binding site [chemical binding]; other site 1306400009983 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1306400009984 KMSKS motif; other site 1306400009985 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1306400009986 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1306400009987 homotrimer interaction site [polypeptide binding]; other site 1306400009988 zinc binding site [ion binding]; other site 1306400009989 CDP-binding sites; other site 1306400009990 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1306400009991 substrate binding site; other site 1306400009992 dimer interface; other site 1306400009993 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1306400009994 DNA repair protein RadA; Provisional; Region: PRK11823 1306400009995 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1306400009996 Walker A motif/ATP binding site; other site 1306400009997 ATP binding site [chemical binding]; other site 1306400009998 Walker B motif; other site 1306400009999 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1306400010000 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1306400010001 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1306400010002 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1306400010003 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1306400010004 active site clefts [active] 1306400010005 zinc binding site [ion binding]; other site 1306400010006 dimer interface [polypeptide binding]; other site 1306400010007 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1306400010008 endonuclease III; Region: ENDO3c; smart00478 1306400010009 minor groove reading motif; other site 1306400010010 helix-hairpin-helix signature motif; other site 1306400010011 substrate binding pocket [chemical binding]; other site 1306400010012 active site 1306400010013 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1306400010014 PE family; Region: PE; pfam00934 1306400010015 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400010016 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1306400010017 catalytic site [active] 1306400010018 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1306400010019 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1306400010020 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1306400010021 Ami_2 domain; Region: Ami_2; smart00644 1306400010022 amidase catalytic site [active] 1306400010023 Zn binding residues [ion binding]; other site 1306400010024 substrate binding site [chemical binding]; other site 1306400010025 PE family; Region: PE; pfam00934 1306400010026 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1306400010027 Clp amino terminal domain; Region: Clp_N; pfam02861 1306400010028 Clp amino terminal domain; Region: Clp_N; pfam02861 1306400010029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400010030 Walker A motif; other site 1306400010031 ATP binding site [chemical binding]; other site 1306400010032 Walker B motif; other site 1306400010033 arginine finger; other site 1306400010034 UvrB/uvrC motif; Region: UVR; pfam02151 1306400010035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400010036 Walker A motif; other site 1306400010037 ATP binding site [chemical binding]; other site 1306400010038 Walker B motif; other site 1306400010039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1306400010040 Lsr2; Region: Lsr2; pfam11774 1306400010041 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1306400010042 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1306400010043 dimer interface [polypeptide binding]; other site 1306400010044 putative anticodon binding site; other site 1306400010045 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1306400010046 motif 1; other site 1306400010047 dimer interface [polypeptide binding]; other site 1306400010048 active site 1306400010049 motif 2; other site 1306400010050 motif 3; other site 1306400010051 pantothenate kinase; Reviewed; Region: PRK13318 1306400010052 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1306400010053 tetramerization interface [polypeptide binding]; other site 1306400010054 active site 1306400010055 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1306400010056 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1306400010057 active site 1306400010058 ATP-binding site [chemical binding]; other site 1306400010059 pantoate-binding site; other site 1306400010060 HXXH motif; other site 1306400010061 Rossmann-like domain; Region: Rossmann-like; pfam10727 1306400010062 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1306400010063 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1306400010064 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1306400010065 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1306400010066 catalytic center binding site [active] 1306400010067 ATP binding site [chemical binding]; other site 1306400010068 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1306400010069 homooctamer interface [polypeptide binding]; other site 1306400010070 active site 1306400010071 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1306400010072 dihydropteroate synthase; Region: DHPS; TIGR01496 1306400010073 substrate binding pocket [chemical binding]; other site 1306400010074 dimer interface [polypeptide binding]; other site 1306400010075 inhibitor binding site; inhibition site 1306400010076 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1306400010077 homodecamer interface [polypeptide binding]; other site 1306400010078 GTP cyclohydrolase I; Provisional; Region: PLN03044 1306400010079 active site 1306400010080 putative catalytic site residues [active] 1306400010081 zinc binding site [ion binding]; other site 1306400010082 GTP-CH-I/GFRP interaction surface; other site 1306400010083 FtsH Extracellular; Region: FtsH_ext; pfam06480 1306400010084 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1306400010085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400010086 Walker A motif; other site 1306400010087 ATP binding site [chemical binding]; other site 1306400010088 Walker B motif; other site 1306400010089 arginine finger; other site 1306400010090 Peptidase family M41; Region: Peptidase_M41; pfam01434 1306400010091 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1306400010092 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400010093 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1306400010094 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400010095 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1306400010096 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1306400010097 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306400010098 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1306400010099 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400010100 PPE family; Region: PPE; pfam00823 1306400010101 PE family; Region: PE; pfam00934 1306400010102 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1306400010103 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1306400010104 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1306400010105 active site 1306400010106 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1306400010107 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1306400010108 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1306400010109 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1306400010110 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1306400010111 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1306400010112 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1306400010113 dimer interface [polypeptide binding]; other site 1306400010114 substrate binding site [chemical binding]; other site 1306400010115 metal binding sites [ion binding]; metal-binding site 1306400010116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1306400010117 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1306400010118 Ligand binding site; other site 1306400010119 Putative Catalytic site; other site 1306400010120 DXD motif; other site 1306400010121 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1306400010122 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1306400010123 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306400010124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400010125 NAD(P) binding site [chemical binding]; other site 1306400010126 active site 1306400010127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1306400010128 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1306400010129 Integrase core domain; Region: rve; pfam00665 1306400010130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1306400010131 transposase; Provisional; Region: PRK06526 1306400010132 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1306400010133 Walker B motif; other site 1306400010134 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1306400010135 MULE transposase domain; Region: MULE; pfam10551 1306400010136 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1306400010137 Fic/DOC family; Region: Fic; cl00960 1306400010138 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1306400010139 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1306400010140 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1306400010141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1306400010142 dimerization interface [polypeptide binding]; other site 1306400010143 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1306400010144 cyclase homology domain; Region: CHD; cd07302 1306400010145 nucleotidyl binding site; other site 1306400010146 metal binding site [ion binding]; metal-binding site 1306400010147 dimer interface [polypeptide binding]; other site 1306400010148 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1306400010149 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1306400010150 active site 1306400010151 interdomain interaction site; other site 1306400010152 putative metal-binding site [ion binding]; other site 1306400010153 nucleotide binding site [chemical binding]; other site 1306400010154 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1306400010155 domain I; other site 1306400010156 phosphate binding site [ion binding]; other site 1306400010157 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1306400010158 domain II; other site 1306400010159 domain III; other site 1306400010160 nucleotide binding site [chemical binding]; other site 1306400010161 DNA binding groove [nucleotide binding] 1306400010162 catalytic site [active] 1306400010163 domain IV; other site 1306400010164 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1306400010165 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1306400010166 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1306400010167 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1306400010168 DNA-binding site [nucleotide binding]; DNA binding site 1306400010169 RNA-binding motif; other site 1306400010170 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1306400010171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1306400010172 ATP binding site [chemical binding]; other site 1306400010173 putative Mg++ binding site [ion binding]; other site 1306400010174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1306400010175 nucleotide binding region [chemical binding]; other site 1306400010176 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1306400010177 PE family; Region: PE; pfam00934 1306400010178 PE family; Region: PE; pfam00934 1306400010179 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1306400010180 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1306400010181 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1306400010182 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1306400010183 Walker A motif; other site 1306400010184 hexamer interface [polypeptide binding]; other site 1306400010185 ATP binding site [chemical binding]; other site 1306400010186 Walker B motif; other site 1306400010187 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1306400010188 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1306400010189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400010190 motif II; other site 1306400010191 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1306400010192 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1306400010193 Walker A/P-loop; other site 1306400010194 ATP binding site [chemical binding]; other site 1306400010195 Q-loop/lid; other site 1306400010196 ABC transporter signature motif; other site 1306400010197 Walker B; other site 1306400010198 D-loop; other site 1306400010199 H-loop/switch region; other site 1306400010200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1306400010201 Walker A/P-loop; other site 1306400010202 ATP binding site [chemical binding]; other site 1306400010203 Q-loop/lid; other site 1306400010204 ABC transporter signature motif; other site 1306400010205 Walker B; other site 1306400010206 D-loop; other site 1306400010207 H-loop/switch region; other site 1306400010208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1306400010209 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1306400010210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400010211 ABC-ATPase subunit interface; other site 1306400010212 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1306400010213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400010214 dimer interface [polypeptide binding]; other site 1306400010215 conserved gate region; other site 1306400010216 ABC-ATPase subunit interface; other site 1306400010217 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1306400010218 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1306400010219 acetyl-CoA synthetase; Provisional; Region: PRK00174 1306400010220 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1306400010221 active site 1306400010222 CoA binding site [chemical binding]; other site 1306400010223 acyl-activating enzyme (AAE) consensus motif; other site 1306400010224 AMP binding site [chemical binding]; other site 1306400010225 acetate binding site [chemical binding]; other site 1306400010226 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1306400010227 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1306400010228 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1306400010229 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1306400010230 putative active site [active] 1306400010231 putative CoA binding site [chemical binding]; other site 1306400010232 nudix motif; other site 1306400010233 metal binding site [ion binding]; metal-binding site 1306400010234 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1306400010235 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306400010236 catalytic residues [active] 1306400010237 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1306400010238 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1306400010239 minor groove reading motif; other site 1306400010240 helix-hairpin-helix signature motif; other site 1306400010241 substrate binding pocket [chemical binding]; other site 1306400010242 active site 1306400010243 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1306400010244 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306400010245 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306400010246 ligand binding site [chemical binding]; other site 1306400010247 flexible hinge region; other site 1306400010248 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1306400010249 putative switch regulator; other site 1306400010250 non-specific DNA interactions [nucleotide binding]; other site 1306400010251 DNA binding site [nucleotide binding] 1306400010252 sequence specific DNA binding site [nucleotide binding]; other site 1306400010253 putative cAMP binding site [chemical binding]; other site 1306400010254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306400010255 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1306400010256 homotrimer interaction site [polypeptide binding]; other site 1306400010257 putative active site [active] 1306400010258 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1306400010259 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1306400010260 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1306400010261 P loop; other site 1306400010262 Nucleotide binding site [chemical binding]; other site 1306400010263 DTAP/Switch II; other site 1306400010264 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1306400010265 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1306400010266 DTAP/Switch II; other site 1306400010267 Switch I; other site 1306400010268 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1306400010269 Transcription factor WhiB; Region: Whib; pfam02467 1306400010270 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1306400010271 Transglycosylase; Region: Transgly; pfam00912 1306400010272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1306400010273 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1306400010274 phosphodiesterase YaeI; Provisional; Region: PRK11340 1306400010275 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1306400010276 putative active site [active] 1306400010277 putative metal binding site [ion binding]; other site 1306400010278 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1306400010279 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1306400010280 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400010281 catalytic residue [active] 1306400010282 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1306400010283 Cytochrome P450; Region: p450; cl12078 1306400010284 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1306400010285 anti sigma factor interaction site; other site 1306400010286 regulatory phosphorylation site [posttranslational modification]; other site 1306400010287 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1306400010288 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1306400010289 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1306400010290 MoxR-like ATPases [General function prediction only]; Region: COG0714 1306400010291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400010292 Walker A motif; other site 1306400010293 ATP binding site [chemical binding]; other site 1306400010294 Walker B motif; other site 1306400010295 arginine finger; other site 1306400010296 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1306400010297 Protein of unknown function DUF58; Region: DUF58; pfam01882 1306400010298 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1306400010299 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1306400010300 glycerol kinase; Provisional; Region: glpK; PRK00047 1306400010301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1306400010302 nucleotide binding site [chemical binding]; other site 1306400010303 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1306400010304 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1306400010305 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1306400010306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400010307 S-adenosylmethionine binding site [chemical binding]; other site 1306400010308 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306400010309 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1306400010310 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400010311 catalytic residue [active] 1306400010312 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1306400010313 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1306400010314 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1306400010315 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1306400010316 putative active site [active] 1306400010317 putative dimer interface [polypeptide binding]; other site 1306400010318 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1306400010319 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1306400010320 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1306400010321 PknH-like extracellular domain; Region: PknH_C; pfam14032 1306400010322 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1306400010323 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1306400010324 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1306400010325 aspartate kinase; Reviewed; Region: PRK06635 1306400010326 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1306400010327 putative nucleotide binding site [chemical binding]; other site 1306400010328 putative catalytic residues [active] 1306400010329 putative Mg ion binding site [ion binding]; other site 1306400010330 putative aspartate binding site [chemical binding]; other site 1306400010331 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1306400010332 putative allosteric regulatory site; other site 1306400010333 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1306400010334 putative allosteric regulatory residue; other site 1306400010335 2-isopropylmalate synthase; Validated; Region: PRK03739 1306400010336 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1306400010337 active site 1306400010338 catalytic residues [active] 1306400010339 metal binding site [ion binding]; metal-binding site 1306400010340 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1306400010341 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1306400010342 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1306400010343 active site 1306400010344 catalytic site [active] 1306400010345 substrate binding site [chemical binding]; other site 1306400010346 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1306400010347 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1306400010348 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1306400010349 catalytic triad [active] 1306400010350 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1306400010351 putative active site [active] 1306400010352 recombination protein RecR; Reviewed; Region: recR; PRK00076 1306400010353 RecR protein; Region: RecR; pfam02132 1306400010354 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1306400010355 putative active site [active] 1306400010356 putative metal-binding site [ion binding]; other site 1306400010357 tetramer interface [polypeptide binding]; other site 1306400010358 hypothetical protein; Validated; Region: PRK00153 1306400010359 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1306400010360 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1306400010361 active site 1306400010362 metal binding site [ion binding]; metal-binding site 1306400010363 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1306400010364 hydrophobic ligand binding site; other site 1306400010365 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400010366 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400010367 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1306400010368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400010369 S-adenosylmethionine binding site [chemical binding]; other site 1306400010370 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1306400010371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400010372 Walker A motif; other site 1306400010373 ATP binding site [chemical binding]; other site 1306400010374 Walker B motif; other site 1306400010375 arginine finger; other site 1306400010376 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1306400010377 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1306400010378 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1306400010379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400010380 catalytic residue [active] 1306400010381 Cutinase; Region: Cutinase; pfam01083 1306400010382 Cutinase; Region: Cutinase; pfam01083 1306400010383 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1306400010384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400010385 NAD(P) binding site [chemical binding]; other site 1306400010386 active site 1306400010387 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1306400010388 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1306400010389 putative NAD(P) binding site [chemical binding]; other site 1306400010390 catalytic Zn binding site [ion binding]; other site 1306400010391 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1306400010392 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1306400010393 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1306400010394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1306400010395 putative substrate translocation pore; other site 1306400010396 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1306400010397 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1306400010398 ligand binding site [chemical binding]; other site 1306400010399 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1306400010400 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1306400010401 active site 1306400010402 nucleophile elbow; other site 1306400010403 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1306400010404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1306400010405 FeS/SAM binding site; other site 1306400010406 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1306400010407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400010408 S-adenosylmethionine binding site [chemical binding]; other site 1306400010409 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1306400010410 nucleotide binding site [chemical binding]; other site 1306400010411 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1306400010412 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1306400010413 active site 1306400010414 DNA binding site [nucleotide binding] 1306400010415 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1306400010416 DNA binding site [nucleotide binding] 1306400010417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1306400010418 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1306400010419 nudix motif; other site 1306400010420 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400010421 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400010422 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1306400010423 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1306400010424 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306400010425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306400010426 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1306400010427 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1306400010428 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1306400010429 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400010430 PPE family; Region: PPE; pfam00823 1306400010431 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400010432 PPE family; Region: PPE; pfam00823 1306400010433 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1306400010434 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1306400010435 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400010436 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400010437 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1306400010438 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1306400010439 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1306400010440 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1306400010441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1306400010442 dimerization interface [polypeptide binding]; other site 1306400010443 putative DNA binding site [nucleotide binding]; other site 1306400010444 putative Zn2+ binding site [ion binding]; other site 1306400010445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 1306400010446 DNA binding domain, excisionase family; Region: excise; TIGR01764 1306400010447 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1306400010448 active site 1306400010449 Int/Topo IB signature motif; other site 1306400010450 Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590 1306400010451 active site 1306400010452 Zn binding site [ion binding]; other site 1306400010453 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1306400010454 prephenate dehydrogenase; Validated; Region: PRK06545 1306400010455 prephenate dehydrogenase; Validated; Region: PRK08507 1306400010456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1306400010457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1306400010458 ABC-ATPase subunit interface; other site 1306400010459 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1306400010460 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1306400010461 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1306400010462 Walker A/P-loop; other site 1306400010463 ATP binding site [chemical binding]; other site 1306400010464 Q-loop/lid; other site 1306400010465 ABC transporter signature motif; other site 1306400010466 Walker B; other site 1306400010467 D-loop; other site 1306400010468 H-loop/switch region; other site 1306400010469 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1306400010470 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1306400010471 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1306400010472 putative active site [active] 1306400010473 putative substrate binding site [chemical binding]; other site 1306400010474 ATP binding site [chemical binding]; other site 1306400010475 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1306400010476 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1306400010477 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1306400010478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1306400010479 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1306400010480 dimerization interface [polypeptide binding]; other site 1306400010481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1306400010482 dimer interface [polypeptide binding]; other site 1306400010483 phosphorylation site [posttranslational modification] 1306400010484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1306400010485 ATP binding site [chemical binding]; other site 1306400010486 Mg2+ binding site [ion binding]; other site 1306400010487 G-X-G motif; other site 1306400010488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1306400010489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1306400010490 active site 1306400010491 phosphorylation site [posttranslational modification] 1306400010492 intermolecular recognition site; other site 1306400010493 dimerization interface [polypeptide binding]; other site 1306400010494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1306400010495 DNA binding site [nucleotide binding] 1306400010496 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 1306400010497 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400010498 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400010499 SnoaL-like domain; Region: SnoaL_2; pfam12680 1306400010500 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1306400010501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1306400010502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1306400010503 homodimer interface [polypeptide binding]; other site 1306400010504 catalytic residue [active] 1306400010505 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1306400010506 TIGR03086 family protein; Region: TIGR03086 1306400010507 enoyl-CoA hydratase; Provisional; Region: PRK06142 1306400010508 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1306400010509 substrate binding site [chemical binding]; other site 1306400010510 oxyanion hole (OAH) forming residues; other site 1306400010511 trimer interface [polypeptide binding]; other site 1306400010512 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1306400010513 Beta-lactamase; Region: Beta-lactamase; pfam00144 1306400010514 potential protein location (hypothetical protein J112_20305 [Mycobacterium tuberculosis]) that overlaps RNA (tRNA-S) 1306400010515 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1306400010516 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1306400010517 NAD(P) binding site [chemical binding]; other site 1306400010518 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1306400010519 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1306400010520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1306400010521 catalytic residue [active] 1306400010522 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1306400010523 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1306400010524 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1306400010525 Walker A/P-loop; other site 1306400010526 ATP binding site [chemical binding]; other site 1306400010527 Q-loop/lid; other site 1306400010528 ABC transporter signature motif; other site 1306400010529 Walker B; other site 1306400010530 D-loop; other site 1306400010531 H-loop/switch region; other site 1306400010532 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1306400010533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306400010534 active site 1306400010535 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1306400010536 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1306400010537 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1306400010538 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1306400010539 NAD binding site [chemical binding]; other site 1306400010540 substrate binding site [chemical binding]; other site 1306400010541 active site 1306400010542 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1306400010543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306400010544 active site 1306400010545 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1306400010546 Peptidase family M23; Region: Peptidase_M23; pfam01551 1306400010547 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1306400010548 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1306400010549 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1306400010550 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1306400010551 Predicted membrane protein [Function unknown]; Region: COG2246 1306400010552 GtrA-like protein; Region: GtrA; pfam04138 1306400010553 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1306400010554 FAD binding domain; Region: FAD_binding_4; pfam01565 1306400010555 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1306400010556 short chain dehydrogenase; Provisional; Region: PRK07904 1306400010557 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1306400010558 NAD(P) binding site [chemical binding]; other site 1306400010559 active site 1306400010560 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1306400010561 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1306400010562 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1306400010563 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1306400010564 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1306400010565 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1306400010566 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1306400010567 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1306400010568 FAD binding site [chemical binding]; other site 1306400010569 substrate binding site [chemical binding]; other site 1306400010570 catalytic residues [active] 1306400010571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306400010572 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1306400010573 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1306400010574 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1306400010575 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1306400010576 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1306400010577 active site 1306400010578 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1306400010579 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400010580 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400010581 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1306400010582 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400010583 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400010584 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400010585 active site 1306400010586 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1306400010587 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400010588 acyl-activating enzyme (AAE) consensus motif; other site 1306400010589 active site 1306400010590 Cutinase; Region: Cutinase; pfam01083 1306400010591 Predicted esterase [General function prediction only]; Region: COG0627 1306400010592 Putative esterase; Region: Esterase; pfam00756 1306400010593 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1306400010594 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1306400010595 active site 1306400010596 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1306400010597 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1306400010598 active site 1306400010599 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1306400010600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400010601 UDP-galactopyranose mutase; Region: GLF; pfam03275 1306400010602 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1306400010603 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1306400010604 amidase catalytic site [active] 1306400010605 Zn binding residues [ion binding]; other site 1306400010606 substrate binding site [chemical binding]; other site 1306400010607 LGFP repeat; Region: LGFP; pfam08310 1306400010608 PE family; Region: PE; pfam00934 1306400010609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1306400010610 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1306400010611 active site 1306400010612 motif I; other site 1306400010613 motif II; other site 1306400010614 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1306400010615 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400010616 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306400010617 putative acyl-acceptor binding pocket; other site 1306400010618 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400010619 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306400010620 putative acyl-acceptor binding pocket; other site 1306400010621 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1306400010622 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1306400010623 putative acyl-acceptor binding pocket; other site 1306400010624 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1306400010625 Phosphotransferase enzyme family; Region: APH; pfam01636 1306400010626 active site 1306400010627 ATP binding site [chemical binding]; other site 1306400010628 antibiotic binding site [chemical binding]; other site 1306400010629 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1306400010630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1306400010631 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1306400010632 iron-sulfur cluster [ion binding]; other site 1306400010633 [2Fe-2S] cluster binding site [ion binding]; other site 1306400010634 Condensation domain; Region: Condensation; pfam00668 1306400010635 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1306400010636 PE-PPE domain; Region: PE-PPE; pfam08237 1306400010637 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1306400010638 Condensation domain; Region: Condensation; pfam00668 1306400010639 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1306400010640 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1306400010641 active site 1306400010642 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1306400010643 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1306400010644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1306400010645 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1306400010646 Enoylreductase; Region: PKS_ER; smart00829 1306400010647 NAD(P) binding site [chemical binding]; other site 1306400010648 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1306400010649 KR domain; Region: KR; pfam08659 1306400010650 putative NADP binding site [chemical binding]; other site 1306400010651 active site 1306400010652 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1306400010653 acyl-CoA synthetase; Validated; Region: PRK05850 1306400010654 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1306400010655 acyl-activating enzyme (AAE) consensus motif; other site 1306400010656 active site 1306400010657 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1306400010658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1306400010659 Probable transposase; Region: OrfB_IS605; pfam01385 1306400010660 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1306400010661 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1306400010662 catalytic residues [active] 1306400010663 catalytic nucleophile [active] 1306400010664 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1306400010665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400010666 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1306400010667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400010668 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1306400010669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1306400010670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1306400010671 Cupin domain; Region: Cupin_2; cl17218 1306400010672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1306400010673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1306400010674 seryl-tRNA synthetase; Provisional; Region: PRK05431 1306400010675 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1306400010676 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1306400010677 dimer interface [polypeptide binding]; other site 1306400010678 active site 1306400010679 motif 1; other site 1306400010680 motif 2; other site 1306400010681 motif 3; other site 1306400010682 Septum formation; Region: Septum_form; pfam13845 1306400010683 Septum formation; Region: Septum_form; pfam13845 1306400010684 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1306400010685 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1306400010686 catalytic core [active] 1306400010687 prephenate dehydratase; Provisional; Region: PRK11898 1306400010688 Prephenate dehydratase; Region: PDT; pfam00800 1306400010689 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1306400010690 putative L-Phe binding site [chemical binding]; other site 1306400010691 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1306400010692 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1306400010693 Ferritin-like domain; Region: Ferritin; pfam00210 1306400010694 ferroxidase diiron center [ion binding]; other site 1306400010695 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1306400010696 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1306400010697 putative active site [active] 1306400010698 catalytic site [active] 1306400010699 putative metal binding site [ion binding]; other site 1306400010700 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1306400010701 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1306400010702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1306400010703 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1306400010704 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1306400010705 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1306400010706 Predicted membrane protein [Function unknown]; Region: COG2119 1306400010707 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1306400010708 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1306400010709 Fimbrial protein; Region: Fimbrial; cl01416 1306400010710 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1306400010711 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1306400010712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1306400010713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1306400010714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1306400010715 hypothetical protein; Provisional; Region: PRK07945 1306400010716 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1306400010717 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1306400010718 active site 1306400010719 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1306400010720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1306400010721 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1306400010722 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1306400010723 active site 1306400010724 dimer interface [polypeptide binding]; other site 1306400010725 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1306400010726 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1306400010727 active site 1306400010728 FMN binding site [chemical binding]; other site 1306400010729 substrate binding site [chemical binding]; other site 1306400010730 3Fe-4S cluster binding site [ion binding]; other site 1306400010731 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1306400010732 domain interface; other site 1306400010733 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306400010734 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1306400010735 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1306400010736 EspG family; Region: ESX-1_EspG; pfam14011 1306400010737 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1306400010738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400010739 Walker A motif; other site 1306400010740 ATP binding site [chemical binding]; other site 1306400010741 Walker B motif; other site 1306400010742 arginine finger; other site 1306400010743 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1306400010744 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306400010745 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400010746 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306400010747 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400010748 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400010749 PE family; Region: PE; pfam00934 1306400010750 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1306400010751 PPE family; Region: PPE; pfam00823 1306400010752 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1306400010753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306400010754 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306400010755 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306400010756 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1306400010757 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1306400010758 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306400010759 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1306400010760 active site 1306400010761 catalytic residues [active] 1306400010762 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1306400010763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1306400010764 Walker A motif; other site 1306400010765 ATP binding site [chemical binding]; other site 1306400010766 Walker B motif; other site 1306400010767 arginine finger; other site 1306400010768 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1306400010769 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306400010770 catalytic residues [active] 1306400010771 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1306400010772 active site 1306400010773 catalytic residues [active] 1306400010774 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1306400010775 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1306400010776 EspG family; Region: ESX-1_EspG; pfam14011 1306400010777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306400010778 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1306400010779 PPE family; Region: PPE; pfam00823 1306400010780 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400010781 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1306400010782 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400010783 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1306400010784 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1306400010785 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1306400010786 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1306400010787 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1306400010788 catalytic residue [active] 1306400010789 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1306400010790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1306400010791 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1306400010792 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1306400010793 active site 1306400010794 NTP binding site [chemical binding]; other site 1306400010795 metal binding triad [ion binding]; metal-binding site 1306400010796 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1306400010797 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1306400010798 Zn2+ binding site [ion binding]; other site 1306400010799 Mg2+ binding site [ion binding]; other site 1306400010800 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1306400010801 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1306400010802 active site 1306400010803 Ap6A binding site [chemical binding]; other site 1306400010804 nudix motif; other site 1306400010805 metal binding site [ion binding]; metal-binding site 1306400010806 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1306400010807 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1306400010808 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1306400010809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1306400010810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1306400010811 DNA binding residues [nucleotide binding] 1306400010812 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1306400010813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1306400010814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1306400010815 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1306400010816 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1306400010817 catalytic residues [active] 1306400010818 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1306400010819 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1306400010820 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1306400010821 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1306400010822 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1306400010823 active site 1306400010824 metal binding site [ion binding]; metal-binding site 1306400010825 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1306400010826 ParB-like nuclease domain; Region: ParB; smart00470 1306400010827 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1306400010828 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306400010829 P-loop; other site 1306400010830 Magnesium ion binding site [ion binding]; other site 1306400010831 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1306400010832 Magnesium ion binding site [ion binding]; other site 1306400010833 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1306400010834 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1306400010835 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1306400010836 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1306400010837 G-X-X-G motif; other site 1306400010838 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1306400010839 RxxxH motif; other site 1306400010840 potential frameshift: common BLAST hit: gi|433637018|ref|YP_007270645.1| Putative OxaA-like inner membrane protein translocase component 1306400010841 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1306400010842 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1306400010843 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399