-- dump date 20140619_153901 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1310114000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1310114000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114000003 Walker A motif; other site 1310114000004 ATP binding site [chemical binding]; other site 1310114000005 Walker B motif; other site 1310114000006 arginine finger; other site 1310114000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1310114000008 DnaA box-binding interface [nucleotide binding]; other site 1310114000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1310114000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1310114000011 putative DNA binding surface [nucleotide binding]; other site 1310114000012 dimer interface [polypeptide binding]; other site 1310114000013 beta-clamp/clamp loader binding surface; other site 1310114000014 beta-clamp/translesion DNA polymerase binding surface; other site 1310114000015 recF protein; Region: recf; TIGR00611 1310114000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1310114000017 Walker A/P-loop; other site 1310114000018 ATP binding site [chemical binding]; other site 1310114000019 Q-loop/lid; other site 1310114000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114000021 ABC transporter signature motif; other site 1310114000022 Walker B; other site 1310114000023 D-loop; other site 1310114000024 H-loop/switch region; other site 1310114000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1310114000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1310114000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114000028 Mg2+ binding site [ion binding]; other site 1310114000029 G-X-G motif; other site 1310114000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1310114000031 anchoring element; other site 1310114000032 dimer interface [polypeptide binding]; other site 1310114000033 ATP binding site [chemical binding]; other site 1310114000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1310114000035 active site 1310114000036 putative metal-binding site [ion binding]; other site 1310114000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1310114000038 DNA gyrase subunit A; Validated; Region: PRK05560 1310114000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1310114000040 CAP-like domain; other site 1310114000041 active site 1310114000042 primary dimer interface [polypeptide binding]; other site 1310114000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310114000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310114000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310114000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310114000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310114000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310114000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1310114000050 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1310114000051 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1310114000052 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1310114000053 active site 1310114000054 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1310114000055 putative septation inhibitor protein; Reviewed; Region: PRK00159 1310114000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1310114000057 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1310114000058 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1310114000059 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1310114000060 glutamine binding [chemical binding]; other site 1310114000061 catalytic triad [active] 1310114000062 potential frameshift: common BLAST hit: gi|471335801|ref|YP_007608514.1| transmembrane serine/threonine-protein kinase B 1310114000063 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310114000064 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310114000065 active site 1310114000066 ATP binding site [chemical binding]; other site 1310114000067 substrate binding site [chemical binding]; other site 1310114000068 activation loop (A-loop); other site 1310114000069 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1310114000070 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310114000071 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1310114000072 potential frameshift: common BLAST hit: gi|433640147|ref|YP_007285906.1| Conserved protein of unknown function with Fha domain 1310114000073 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1310114000074 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310114000075 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310114000076 phosphopeptide binding site; other site 1310114000077 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1310114000078 FMN binding site [chemical binding]; other site 1310114000079 substrate binding site [chemical binding]; other site 1310114000080 putative catalytic residue [active] 1310114000081 Transcription factor WhiB; Region: Whib; pfam02467 1310114000082 potential frameshift: common BLAST hit: gi|471335811|ref|YP_007608524.1| transcriptional regulator 1310114000083 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1310114000084 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1310114000085 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1310114000086 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1310114000087 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1310114000088 potential frameshift: common BLAST hit: gi|449062011|ref|YP_007429094.1| 8-amino-7-oxononanoate synthase BioF2 1310114000089 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1310114000090 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1310114000091 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1310114000092 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114000093 acyl-activating enzyme (AAE) consensus motif; other site 1310114000094 active site 1310114000095 H+ Antiporter protein; Region: 2A0121; TIGR00900 1310114000096 hypothetical protein; Validated; Region: PRK00228 1310114000097 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1310114000098 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1310114000099 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114000100 active site 1310114000101 HIGH motif; other site 1310114000102 nucleotide binding site [chemical binding]; other site 1310114000103 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1310114000104 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114000105 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114000106 active site 1310114000107 KMSKS motif; other site 1310114000108 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1310114000109 tRNA binding surface [nucleotide binding]; other site 1310114000110 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310114000111 MarR family; Region: MarR; pfam01047 1310114000112 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310114000113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310114000114 DNA-binding site [nucleotide binding]; DNA binding site 1310114000115 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1310114000116 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114000117 potential frameshift: common BLAST hit: gi|471335835|ref|YP_007608548.1| hydrolase 1310114000118 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1310114000119 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1310114000120 Predicted transcriptional regulators [Transcription]; Region: COG1695 1310114000121 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1310114000122 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310114000123 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1310114000124 Transglycosylase; Region: Transgly; pfam00912 1310114000125 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310114000126 Predicted integral membrane protein [Function unknown]; Region: COG5650 1310114000127 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1310114000128 conserved cys residue [active] 1310114000129 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1310114000130 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1310114000131 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1310114000132 dimer interface [polypeptide binding]; other site 1310114000133 ssDNA binding site [nucleotide binding]; other site 1310114000134 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1310114000135 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1310114000136 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1310114000137 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1310114000138 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1310114000139 replicative DNA helicase; Validated; Region: PRK07773 1310114000140 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1310114000141 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1310114000142 Walker A motif; other site 1310114000143 ATP binding site [chemical binding]; other site 1310114000144 Walker B motif; other site 1310114000145 DNA binding loops [nucleotide binding] 1310114000146 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1310114000147 protein-splicing catalytic site; other site 1310114000148 thioester formation/cholesterol transfer; other site 1310114000149 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1310114000150 protein-splicing catalytic site; other site 1310114000151 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1310114000152 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1310114000153 ADP-ribose binding site [chemical binding]; other site 1310114000154 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1310114000155 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1310114000156 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1310114000157 potential frameshift: common BLAST hit: gi|385993181|ref|YP_005911479.1| oxidoreductase 1310114000158 hypothetical protein; Provisional; Region: PRK12438 1310114000159 hypothetical protein; Validated; Region: PRK00068 1310114000160 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1310114000161 homotetrameric interface [polypeptide binding]; other site 1310114000162 putative active site [active] 1310114000163 metal binding site [ion binding]; metal-binding site 1310114000164 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1310114000165 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1310114000166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000168 short chain dehydrogenase; Provisional; Region: PRK06197 1310114000169 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1310114000170 putative NAD(P) binding site [chemical binding]; other site 1310114000171 active site 1310114000172 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1310114000173 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1310114000174 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1310114000175 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1310114000176 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1310114000177 dimer interface [polypeptide binding]; other site 1310114000178 active site 1310114000179 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1310114000180 folate binding site [chemical binding]; other site 1310114000181 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1310114000182 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1310114000183 putative NTP binding site [chemical binding]; other site 1310114000184 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310114000185 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310114000186 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310114000187 Walker A/P-loop; other site 1310114000188 ATP binding site [chemical binding]; other site 1310114000189 Q-loop/lid; other site 1310114000190 ABC transporter signature motif; other site 1310114000191 Walker B; other site 1310114000192 D-loop; other site 1310114000193 H-loop/switch region; other site 1310114000194 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310114000195 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310114000196 ligand binding site [chemical binding]; other site 1310114000197 flexible hinge region; other site 1310114000198 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1310114000199 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310114000200 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1310114000201 active site 1310114000202 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1310114000203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310114000204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114000205 homodimer interface [polypeptide binding]; other site 1310114000206 catalytic residue [active] 1310114000207 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114000208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114000211 dimerization interface [polypeptide binding]; other site 1310114000212 putative DNA binding site [nucleotide binding]; other site 1310114000213 putative Zn2+ binding site [ion binding]; other site 1310114000214 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1310114000215 potential frameshift: common BLAST hit: gi|449062069|ref|YP_007429152.1| oxidoreductase 1310114000216 NADH dehydrogenase; Region: NADHdh; cl00469 1310114000217 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 1310114000218 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 1310114000219 potential frameshift: common BLAST hit: gi|397671869|ref|YP_006513403.1| hydrogenase-4 component F 1310114000220 potential frameshift: common BLAST hit: gi|397671869|ref|YP_006513403.1| hydrogenase-4 component F 1310114000221 potential frameshift: common BLAST hit: gi|397671869|ref|YP_006513403.1| hydrogenase-4 component F 1310114000222 potential frameshift: common BLAST hit: gi|471335884|ref|YP_007608597.1| formate hydrogenase 1310114000223 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1310114000224 putative hydrophobic ligand binding site [chemical binding]; other site 1310114000225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114000226 ferredoxin--nitrite reductase; Region: PLN02431 1310114000227 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1310114000228 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1310114000229 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1310114000230 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310114000231 metal-binding site [ion binding] 1310114000232 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1310114000233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310114000234 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310114000235 Predicted integral membrane protein [Function unknown]; Region: COG5660 1310114000236 Putative zinc-finger; Region: zf-HC2; pfam13490 1310114000237 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114000238 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114000239 active site 1310114000240 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114000241 potential frameshift: common BLAST hit: gi|397671880|ref|YP_006513414.1| PPE family protein 1310114000242 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1310114000243 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1310114000244 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1310114000245 acyl-CoA synthetase; Validated; Region: PRK05857 1310114000246 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114000247 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1310114000248 acyl-activating enzyme (AAE) consensus motif; other site 1310114000249 acyl-activating enzyme (AAE) consensus motif; other site 1310114000250 AMP binding site [chemical binding]; other site 1310114000251 active site 1310114000252 CoA binding site [chemical binding]; other site 1310114000253 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310114000254 potential frameshift: common BLAST hit: gi|471335899|ref|YP_007608612.1| peptide synthetase 1310114000255 potential frameshift: common BLAST hit: gi|148659864|ref|YP_001281387.1| peptide synthetase 1310114000256 Predicted membrane protein [Function unknown]; Region: COG3336 1310114000257 potential frameshift: common BLAST hit: gi|392430514|ref|YP_006471558.1| cation-transporter P-type ATPase B ctpB 1310114000258 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1310114000259 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310114000260 metal-binding site [ion binding] 1310114000261 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310114000262 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310114000263 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310114000264 ligand binding site [chemical binding]; other site 1310114000265 flexible hinge region; other site 1310114000266 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1310114000267 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1310114000268 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1310114000269 potential frameshift: common BLAST hit: gi|383306039|ref|YP_005358850.1| cation-transporter ATPase I CtpI 1310114000270 potential frameshift: common BLAST hit: gi|471335905|ref|YP_007608618.1| cation-transporter ATPase I 1310114000271 potential frameshift: common BLAST hit: gi|57116691|ref|YP_177692.1| PE-PGRS family protein PE_PGRS1 1310114000272 Rhomboid family; Region: Rhomboid; pfam01694 1310114000273 potential frameshift: common BLAST hit: gi|471335910|ref|YP_007608623.1| transmembrane acyltransferase 1310114000274 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310114000275 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1310114000276 NADP-binding site; other site 1310114000277 homotetramer interface [polypeptide binding]; other site 1310114000278 substrate binding site [chemical binding]; other site 1310114000279 homodimer interface [polypeptide binding]; other site 1310114000280 active site 1310114000281 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1310114000282 dimer interface [polypeptide binding]; other site 1310114000283 active site 1310114000284 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1310114000285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310114000286 active site 1310114000287 motif I; other site 1310114000288 motif II; other site 1310114000289 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1310114000290 potential frameshift: common BLAST hit: gi|385993226|ref|YP_005911524.1| membrane protein 1310114000291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310114000292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310114000293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1310114000294 dimerization interface [polypeptide binding]; other site 1310114000295 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1310114000296 TPP-binding site; other site 1310114000297 dimer interface [polypeptide binding]; other site 1310114000298 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310114000299 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310114000300 PYR/PP interface [polypeptide binding]; other site 1310114000301 dimer interface [polypeptide binding]; other site 1310114000302 TPP binding site [chemical binding]; other site 1310114000303 potential frameshift: common BLAST hit: gi|471335919|ref|YP_007608632.1| acyl-CoA synthetase 1310114000304 elongation factor G; Reviewed; Region: PRK12740 1310114000305 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310114000306 Switch I region; other site 1310114000307 G3 box; other site 1310114000308 Switch II region; other site 1310114000309 GTP/Mg2+ binding site [chemical binding]; other site 1310114000310 G4 box; other site 1310114000311 G5 box; other site 1310114000312 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1310114000313 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1310114000314 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1310114000315 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310114000316 G1 box; other site 1310114000317 GTP/Mg2+ binding site [chemical binding]; other site 1310114000318 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1310114000319 PE family; Region: PE; pfam00934 1310114000320 potential frameshift: common BLAST hit: gi|471335926|ref|YP_007608639.1| serine protease 1310114000321 trehalose synthase; Region: treS_nterm; TIGR02456 1310114000322 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1310114000323 active site 1310114000324 catalytic site [active] 1310114000325 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1310114000326 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1310114000327 Predicted membrane protein [Function unknown]; Region: COG3619 1310114000328 Predicted esterase [General function prediction only]; Region: COG0627 1310114000329 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1310114000330 putative active site [active] 1310114000331 putative catalytic site [active] 1310114000332 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114000333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114000334 active site 1310114000335 potential frameshift: common BLAST hit: gi|433640264|ref|YP_007286023.1| Putative f420-dependent glucose-6-phosphate dehydrogenase Fgd2 1310114000336 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1310114000337 Coenzyme A binding pocket [chemical binding]; other site 1310114000338 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1310114000339 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1310114000340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000342 potential frameshift: common BLAST hit: gi|471335939|ref|YP_007608652.1| cytochrome P450 138 1310114000343 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1310114000344 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310114000345 potential frameshift: common BLAST hit: gi|471335942|ref|YP_007608655.1| oxidoreductase 1310114000346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1310114000347 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1310114000348 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1310114000349 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310114000350 minor groove reading motif; other site 1310114000351 helix-hairpin-helix signature motif; other site 1310114000352 active site 1310114000353 potential frameshift: common BLAST hit: gi|471335946|ref|YP_007608659.1| transmembrane protein 1310114000354 potential frameshift: common BLAST hit: gi|471335946|ref|YP_007608659.1| transmembrane protein 1310114000355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000357 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1310114000358 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1310114000359 NAD(P) binding site [chemical binding]; other site 1310114000360 catalytic residues [active] 1310114000361 short chain dehydrogenase; Provisional; Region: PRK07791 1310114000362 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1310114000363 NAD binding site [chemical binding]; other site 1310114000364 homodimer interface [polypeptide binding]; other site 1310114000365 active site 1310114000366 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1310114000367 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1310114000368 NAD(P) binding site [chemical binding]; other site 1310114000369 PE family; Region: PE; pfam00934 1310114000370 PE-PPE domain; Region: PE-PPE; pfam08237 1310114000371 PE-PPE domain; Region: PE-PPE; pfam08237 1310114000372 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1310114000373 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1310114000374 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1310114000375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114000376 active site 1310114000377 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1310114000378 potential frameshift: common BLAST hit: gi|471335961|ref|YP_007608674.1| NAD(P) transhydrogenase subunit alpha 1310114000379 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1310114000380 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1310114000381 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1310114000382 potential frameshift: common BLAST hit: gi|471335963|ref|YP_007608676.1| NAD(P) transhydrogenase subunit beta 1310114000383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000385 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1310114000386 PE family; Region: PE; pfam00934 1310114000387 PE-PPE domain; Region: PE-PPE; pfam08237 1310114000388 PE-PPE domain; Region: PE-PPE; pfam08237 1310114000389 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310114000390 FAD binding domain; Region: FAD_binding_4; pfam01565 1310114000391 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1310114000392 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114000393 NAD(P) binding site [chemical binding]; other site 1310114000394 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1310114000395 active site 1310114000396 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310114000397 putative hydrophobic ligand binding site [chemical binding]; other site 1310114000398 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1310114000399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310114000400 DNA-binding site [nucleotide binding]; DNA binding site 1310114000401 FCD domain; Region: FCD; pfam07729 1310114000402 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1310114000403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114000404 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1310114000405 acyl-activating enzyme (AAE) consensus motif; other site 1310114000406 acyl-activating enzyme (AAE) consensus motif; other site 1310114000407 putative AMP binding site [chemical binding]; other site 1310114000408 putative active site [active] 1310114000409 putative CoA binding site [chemical binding]; other site 1310114000410 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310114000411 Permease; Region: Permease; pfam02405 1310114000412 Permease; Region: Permease; pfam02405 1310114000413 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310114000414 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114000415 mce related protein; Region: MCE; pfam02470 1310114000416 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310114000417 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114000418 mce related protein; Region: MCE; pfam02470 1310114000419 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310114000420 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114000421 mce related protein; Region: MCE; pfam02470 1310114000422 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114000423 mce related protein; Region: MCE; pfam02470 1310114000424 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114000425 mce related protein; Region: MCE; pfam02470 1310114000426 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114000427 mce related protein; Region: MCE; pfam02470 1310114000428 RDD family; Region: RDD; pfam06271 1310114000429 potential frameshift: common BLAST hit: gi|471335984|ref|YP_007608697.1| mce associated membrane protein 1310114000430 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1310114000431 potential frameshift: common BLAST hit: gi|471335986|ref|YP_007608699.1| transmembrane protein 1310114000432 potential frameshift: common BLAST hit: gi|471335986|ref|YP_007608699.1| transmembrane protein 1310114000433 Pirin-related protein [General function prediction only]; Region: COG1741 1310114000434 Pirin; Region: Pirin; pfam02678 1310114000435 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 1310114000436 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114000437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310114000438 DNA binding residues [nucleotide binding] 1310114000439 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310114000440 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1310114000441 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310114000442 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1310114000443 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1310114000444 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1310114000445 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1310114000446 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1310114000447 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1310114000448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114000449 S-adenosylmethionine binding site [chemical binding]; other site 1310114000450 SPW repeat; Region: SPW; pfam03779 1310114000451 SPW repeat; Region: SPW; pfam03779 1310114000452 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1310114000453 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1310114000454 putative homodimer interface [polypeptide binding]; other site 1310114000455 putative homotetramer interface [polypeptide binding]; other site 1310114000456 putative allosteric switch controlling residues; other site 1310114000457 putative metal binding site [ion binding]; other site 1310114000458 putative homodimer-homodimer interface [polypeptide binding]; other site 1310114000459 potential frameshift: common BLAST hit: gi|433640322|ref|YP_007286081.1| Conserved membrane protein of unknown function 1310114000460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310114000461 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1310114000462 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310114000463 potential frameshift: common BLAST hit: gi|471336001|ref|YP_007608714.1| drugs-transport transmembrane ATP-bindingprotein ABC transporter 1310114000464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310114000465 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310114000466 dimerization interface [polypeptide binding]; other site 1310114000467 DNA binding residues [nucleotide binding] 1310114000468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000470 potential frameshift: common BLAST hit: gi|471336005|ref|YP_007608718.1| oxidoreductase 1310114000471 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1310114000472 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1310114000473 active site 1310114000474 Zn binding site [ion binding]; other site 1310114000475 potential frameshift: common BLAST hit: gi|471336010|ref|YP_007608723.1| transmembrane transport protein 1310114000476 potential frameshift: common BLAST hit: gi|471336010|ref|YP_007608723.1| transmembrane transport protein 1310114000477 potential frameshift: common BLAST hit: gi|471336010|ref|YP_007608723.1| transmembrane transport protein 1310114000478 Predicted integral membrane protein [Function unknown]; Region: COG0392 1310114000479 Predicted integral membrane protein [Function unknown]; Region: COG0392 1310114000480 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1310114000481 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1310114000482 MMPL family; Region: MMPL; pfam03176 1310114000483 MMPL family; Region: MMPL; pfam03176 1310114000484 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1310114000485 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1310114000486 active site 1310114000487 substrate-binding site [chemical binding]; other site 1310114000488 metal-binding site [ion binding] 1310114000489 GTP binding site [chemical binding]; other site 1310114000490 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1310114000491 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1310114000492 active site 1310114000493 (T/H)XGH motif; other site 1310114000494 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1310114000495 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1310114000496 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1310114000497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114000498 FeS/SAM binding site; other site 1310114000499 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1310114000500 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114000501 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1310114000502 acyl-activating enzyme (AAE) consensus motif; other site 1310114000503 acyl-activating enzyme (AAE) consensus motif; other site 1310114000504 putative AMP binding site [chemical binding]; other site 1310114000505 putative active site [active] 1310114000506 putative CoA binding site [chemical binding]; other site 1310114000507 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114000508 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114000509 active site 1310114000510 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1310114000511 putative active site [active] 1310114000512 putative catalytic site [active] 1310114000513 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310114000514 active site 2 [active] 1310114000515 active site 1 [active] 1310114000516 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310114000517 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310114000518 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1310114000519 Moco binding site; other site 1310114000520 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310114000521 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310114000522 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114000523 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114000524 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1310114000525 potential frameshift: common BLAST hit: gi|471336030|ref|YP_007608743.1| enoyl-CoA hydratase 1310114000526 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1310114000527 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310114000528 NAD binding site [chemical binding]; other site 1310114000529 catalytic residues [active] 1310114000530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114000531 S-adenosylmethionine binding site [chemical binding]; other site 1310114000532 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1310114000533 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310114000534 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310114000535 putative active site [active] 1310114000536 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1310114000537 active site 1310114000538 substrate binding pocket [chemical binding]; other site 1310114000539 homodimer interaction site [polypeptide binding]; other site 1310114000540 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114000541 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114000542 active site 1310114000543 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1310114000544 active site 1310114000545 diiron metal binding site [ion binding]; other site 1310114000546 potential frameshift: common BLAST hit: gi|397672022|ref|YP_006513557.1| succinate-semialdehyde dehydrogenase [NADP+] 1 1310114000547 Lipase maturation factor; Region: LMF1; pfam06762 1310114000548 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1310114000549 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1310114000550 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1310114000551 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1310114000552 potential frameshift: common BLAST hit: gi|471336047|ref|YP_007608760.1| lipoprotein 1310114000553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000555 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310114000556 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310114000557 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1310114000558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114000559 NAD(P) binding site [chemical binding]; other site 1310114000560 active site 1310114000561 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1310114000562 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310114000563 dimer interface [polypeptide binding]; other site 1310114000564 active site 1310114000565 potential frameshift: common BLAST hit: gi|392430661|ref|YP_006471705.1| acyl-CoA dehydrogenase fadE5 1310114000566 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1310114000567 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1310114000568 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310114000569 catalytic loop [active] 1310114000570 iron binding site [ion binding]; other site 1310114000571 potential frameshift: common BLAST hit: gi|471336058|ref|YP_007608771.1| succinate dehydrogenase flavoprotein subunit 1310114000572 potential protein location (hypothetical protein) that overlaps protein (succinate dehydrogenase flavoprotein subunit) 1310114000573 potential protein location (hypothetical protein) that overlaps protein (succinate dehydrogenase flavoprotein subunit) 1310114000574 potential protein location (hypothetical protein) that overlaps protein (succinate dehydrogenase flavoprotein subunit) 1310114000575 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1310114000576 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1310114000577 putative dimer interface [polypeptide binding]; other site 1310114000578 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1310114000579 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1310114000580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114000581 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1310114000582 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1310114000583 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1310114000584 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1310114000585 homotrimer interface [polypeptide binding]; other site 1310114000586 Walker A motif; other site 1310114000587 GTP binding site [chemical binding]; other site 1310114000588 Walker B motif; other site 1310114000589 cobyric acid synthase; Provisional; Region: PRK00784 1310114000590 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1310114000591 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1310114000592 catalytic triad [active] 1310114000593 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000594 PPE family; Region: PPE; pfam00823 1310114000595 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1310114000596 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1310114000597 putative active site [active] 1310114000598 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1310114000599 putative active site [active] 1310114000600 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1310114000601 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1310114000602 active site 1310114000603 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1310114000604 DNA binding site [nucleotide binding] 1310114000605 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1310114000606 potential frameshift: common BLAST hit: gi|471336071|ref|YP_007608784.1| aminoglycoside 2'-N-acetyltransferase 1310114000607 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1310114000608 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1310114000609 potential frameshift: common BLAST hit: gi|471336074|ref|YP_007608787.1| periplasmic iron-transport lipoprotein 1310114000610 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1310114000611 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1310114000612 potential frameshift: common BLAST hit: gi|385993373|ref|YP_005911671.1| 5-oxoprolinase 1310114000613 potential frameshift: common BLAST hit: gi|385993373|ref|YP_005911671.1| 5-oxoprolinase 1310114000614 potential frameshift: common BLAST hit: gi|471336076|ref|YP_007608789.1| integral membrane nitrite extrusion protein 1310114000615 potential frameshift: common BLAST hit: gi|383306191|ref|YP_005359002.1| putative integral membrane nitrite extrusion protein NARU 1310114000616 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1310114000617 potential frameshift: common BLAST hit: gi|397672058|ref|YP_006513593.1| DNA polymerase LigD, polymerase domain-containing protein 1310114000618 potential frameshift: common BLAST hit: gi|397672058|ref|YP_006513593.1| DNA polymerase LigD, polymerase domain-containing protein 1310114000619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114000620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114000621 active site 1310114000622 CoA binding site [chemical binding]; other site 1310114000623 AMP binding site [chemical binding]; other site 1310114000624 potential frameshift: common BLAST hit: gi|383306195|ref|YP_005359006.1| acyl-CoA dehydrogenase 1310114000625 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1310114000626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000628 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1310114000629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310114000630 Zn binding site [ion binding]; other site 1310114000631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1310114000632 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310114000633 putative active site [active] 1310114000634 PE family; Region: PE; pfam00934 1310114000635 potential frameshift: common BLAST hit: gi|397672071|ref|YP_006513606.1| PPE family protein 1310114000636 potential frameshift: common BLAST hit: gi|397672071|ref|YP_006513606.1| PPE family protein 1310114000637 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114000638 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1310114000639 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114000640 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1310114000641 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310114000642 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310114000643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114000644 Walker A motif; other site 1310114000645 ATP binding site [chemical binding]; other site 1310114000646 Walker B motif; other site 1310114000647 arginine finger; other site 1310114000648 Protein of unknown function (DUF690); Region: DUF690; cl04939 1310114000649 Protein of unknown function (DUF690); Region: DUF690; cl04939 1310114000650 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310114000651 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310114000652 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1310114000653 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310114000654 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310114000655 potential frameshift: common BLAST hit: gi|471336101|ref|YP_007608814.1| PPE family protein 1310114000656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310114000657 EspG family; Region: ESX-1_EspG; pfam14011 1310114000658 potential frameshift: common BLAST hit: gi|449062287|ref|YP_007429370.1| transmembrane protein 1310114000659 potential frameshift: common BLAST hit: gi|433625396|ref|YP_007259025.1| ESX conserved component EccD3 1310114000660 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310114000661 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1310114000662 active site 1310114000663 catalytic residues [active] 1310114000664 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1310114000665 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1310114000666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114000667 S-adenosylmethionine binding site [chemical binding]; other site 1310114000668 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 1310114000669 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 1310114000670 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1310114000671 Sulfatase; Region: Sulfatase; cl17466 1310114000672 hypothetical protein; Region: PHA01748 1310114000673 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310114000674 putative active site [active] 1310114000675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114000678 protochlorophyllide reductase; Region: PLN00015 1310114000679 NAD(P) binding site [chemical binding]; other site 1310114000680 active site 1310114000681 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114000682 autotransport protein MisL; Provisional; Region: PRK15313 1310114000683 autotransport protein MisL; Provisional; Region: PRK15313 1310114000684 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000685 PPE family; Region: PPE; pfam00823 1310114000686 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1310114000687 putative FMN binding site [chemical binding]; other site 1310114000688 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1310114000689 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1310114000690 active site 1310114000691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1310114000692 SnoaL-like domain; Region: SnoaL_4; pfam13577 1310114000693 SnoaL-like domain; Region: SnoaL_3; pfam13474 1310114000694 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1310114000695 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1310114000696 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1310114000697 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1310114000698 active site 1310114000699 catalytic residues [active] 1310114000700 potential frameshift: common BLAST hit: gi|471336131|ref|YP_007608844.1| muconolactone isomerase 1310114000701 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1310114000702 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1310114000703 active site 1310114000704 catalytic site [active] 1310114000705 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1310114000706 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 1310114000707 putative substrate binding pocket [chemical binding]; other site 1310114000708 AB domain interface; other site 1310114000709 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1310114000710 trimer interface [polypeptide binding]; other site 1310114000711 active site 1310114000712 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1310114000713 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1310114000714 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1310114000715 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1310114000716 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1310114000717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114000718 dimerization interface [polypeptide binding]; other site 1310114000719 putative DNA binding site [nucleotide binding]; other site 1310114000720 putative Zn2+ binding site [ion binding]; other site 1310114000721 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310114000722 active site residue [active] 1310114000723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114000724 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114000725 Cytochrome P450; Region: p450; cl12078 1310114000726 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1310114000727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000728 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1310114000729 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310114000730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114000731 S-adenosylmethionine binding site [chemical binding]; other site 1310114000732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114000733 potential frameshift: common BLAST hit: gi|449062326|ref|YP_007429409.1| dehydrogenase/reductase 1310114000734 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310114000735 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1310114000736 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310114000737 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1310114000738 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1310114000739 substrate binding site; other site 1310114000740 tetramer interface; other site 1310114000741 PE family; Region: PE; pfam00934 1310114000742 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114000743 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114000744 active site 1310114000745 aminotransferase AlaT; Validated; Region: PRK09265 1310114000746 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310114000747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114000748 homodimer interface [polypeptide binding]; other site 1310114000749 catalytic residue [active] 1310114000750 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1310114000751 4Fe-4S binding domain; Region: Fer4; pfam00037 1310114000752 Cysteine-rich domain; Region: CCG; pfam02754 1310114000753 Cysteine-rich domain; Region: CCG; pfam02754 1310114000754 potential frameshift: common BLAST hit: gi|397672130|ref|YP_006513665.1| transcriptional regulator 1310114000755 potential frameshift: common BLAST hit: gi|433625437|ref|YP_007259066.1| Conserved protein of unknown function, isoniazid inductible gene 1310114000756 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1310114000757 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310114000758 G1 box; other site 1310114000759 GTP/Mg2+ binding site [chemical binding]; other site 1310114000760 G2 box; other site 1310114000761 Switch I region; other site 1310114000762 G3 box; other site 1310114000763 Switch II region; other site 1310114000764 G4 box; other site 1310114000765 G5 box; other site 1310114000766 potential frameshift: common BLAST hit: gi|471336159|ref|YP_007608872.1| isoniazid inductible gene protein 1310114000767 potential frameshift: common BLAST hit: gi|471336159|ref|YP_007608872.1| isoniazid inductible gene protein 1310114000768 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1310114000769 TIGR04255 family protein; Region: sporadTIGR04255 1310114000770 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1310114000771 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1310114000772 nucleotide binding site [chemical binding]; other site 1310114000773 NEF interaction site [polypeptide binding]; other site 1310114000774 SBD interface [polypeptide binding]; other site 1310114000775 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1310114000776 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1310114000777 dimer interface [polypeptide binding]; other site 1310114000778 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1310114000779 potential frameshift: common BLAST hit: gi|221230825|ref|YP_002504241.1| molecular chaperone DnaJ 1310114000780 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1310114000781 DNA binding residues [nucleotide binding] 1310114000782 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310114000783 putative dimer interface [polypeptide binding]; other site 1310114000784 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000785 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000786 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000787 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000788 PPE family; Region: PPE; pfam00823 1310114000789 PPE family; Region: PPE; pfam00823 1310114000790 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1310114000791 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1310114000792 GDP-binding site [chemical binding]; other site 1310114000793 ACT binding site; other site 1310114000794 IMP binding site; other site 1310114000795 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1310114000796 Peptidase family M50; Region: Peptidase_M50; pfam02163 1310114000797 active site 1310114000798 putative substrate binding region [chemical binding]; other site 1310114000799 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1310114000800 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1310114000801 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1310114000802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1310114000803 Divalent cation transporter; Region: MgtE; pfam01769 1310114000804 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1310114000805 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1310114000806 active site 1310114000807 intersubunit interface [polypeptide binding]; other site 1310114000808 zinc binding site [ion binding]; other site 1310114000809 Na+ binding site [ion binding]; other site 1310114000810 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1310114000811 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1310114000812 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1310114000813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1310114000814 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1310114000815 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1310114000816 metal ion-dependent adhesion site (MIDAS); other site 1310114000817 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1310114000818 putative hydrophobic ligand binding site [chemical binding]; other site 1310114000819 MoxR-like ATPases [General function prediction only]; Region: COG0714 1310114000820 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1310114000821 Ligand binding site; other site 1310114000822 metal-binding site 1310114000823 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1310114000824 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1310114000825 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1310114000826 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1310114000827 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1310114000828 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310114000829 catalytic loop [active] 1310114000830 iron binding site [ion binding]; other site 1310114000831 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1310114000832 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1310114000833 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1310114000834 potential frameshift: common BLAST hit: gi|397672167|ref|YP_006513702.1| xanthine dehydrogenase accessory factor 1310114000835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310114000836 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1310114000837 dimerization interface [polypeptide binding]; other site 1310114000838 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1310114000839 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310114000840 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310114000841 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310114000842 active site 1310114000843 AMP deaminase; Provisional; Region: PTZ00310 1310114000844 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1310114000845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114000846 Walker A motif; other site 1310114000847 ATP binding site [chemical binding]; other site 1310114000848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1310114000849 Clp amino terminal domain; Region: Clp_N; pfam02861 1310114000850 potential frameshift: common BLAST hit: gi|392430800|ref|YP_006471844.1| monooxygenase 1310114000851 potential frameshift: common BLAST hit: gi|148821582|ref|YP_001286336.1| LuxR family transcriptional regulator 1310114000852 potential frameshift: common BLAST hit: gi|31791563|ref|NP_854056.1| LuxR family transcriptional regulator 1310114000853 potential frameshift: common BLAST hit: gi|31791563|ref|NP_854056.1| LuxR family transcriptional regulator 1310114000854 potential frameshift: common BLAST hit: gi|433640509|ref|YP_007286268.1| Putative transcriptional regulatory protein (probably 1310114000855 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000856 PPE family; Region: PPE; pfam00823 1310114000857 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1310114000858 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 1310114000859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310114000860 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1310114000861 active site residue [active] 1310114000862 potential frameshift: common BLAST hit: gi|471336211|ref|YP_007608924.1| O-succinylhomoserine sulfhydrylase 1310114000863 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1310114000864 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310114000865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114000866 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114000867 potential frameshift: common BLAST hit: gi|449062387|ref|YP_007429470.1| 13E12 repeat family protein 1310114000868 PLD-like domain; Region: PLDc_2; pfam13091 1310114000869 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114000870 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114000871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114000872 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114000873 active site 1310114000874 MMPL family; Region: MMPL; pfam03176 1310114000875 MMPL family; Region: MMPL; pfam03176 1310114000876 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310114000877 acyl-CoA synthetase; Validated; Region: PRK05850 1310114000878 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114000879 acyl-activating enzyme (AAE) consensus motif; other site 1310114000880 active site 1310114000881 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310114000882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114000883 active site 1310114000884 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1310114000885 potential frameshift: common BLAST hit: gi|385993505|ref|YP_005911803.1| membrane bound polyketide synthase pks6 1310114000886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310114000887 potential frameshift: common BLAST hit: gi|449062405|ref|YP_007429488.1| F420-dependent glucose-6-phosphate dehydrogenase 1310114000888 phosphate acetyltransferase; Reviewed; Region: PRK05632 1310114000889 DRTGG domain; Region: DRTGG; pfam07085 1310114000890 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1310114000891 propionate/acetate kinase; Provisional; Region: PRK12379 1310114000892 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1310114000893 potential frameshift: common BLAST hit: gi|471336232|ref|YP_007608945.1| serine/threonine-protein kinase 1310114000894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1310114000895 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1310114000896 substrate binding pocket [chemical binding]; other site 1310114000897 membrane-bound complex binding site; other site 1310114000898 hinge residues; other site 1310114000899 potential frameshift: common BLAST hit: gi|471336235|ref|YP_007608948.1| 7,8-dihydro-8-oxoguanine-triphosphatase 1310114000900 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1310114000901 thiamine phosphate binding site [chemical binding]; other site 1310114000902 active site 1310114000903 pyrophosphate binding site [ion binding]; other site 1310114000904 potential frameshift: common BLAST hit: gi|471336237|ref|YP_007608950.1| thiamine biosynthesis oxidoreductase 1310114000905 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1310114000906 thiS-thiF/thiG interaction site; other site 1310114000907 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1310114000908 ThiS interaction site; other site 1310114000909 putative active site [active] 1310114000910 tetramer interface [polypeptide binding]; other site 1310114000911 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1310114000912 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1310114000913 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1310114000914 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1310114000915 PA/protease or protease-like domain interface [polypeptide binding]; other site 1310114000916 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1310114000917 active site 1310114000918 metal binding site [ion binding]; metal-binding site 1310114000919 Predicted metalloprotease [General function prediction only]; Region: COG2321 1310114000920 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1310114000921 Zn binding site [ion binding]; other site 1310114000922 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1310114000923 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1310114000924 dimer interface [polypeptide binding]; other site 1310114000925 substrate binding site [chemical binding]; other site 1310114000926 ATP binding site [chemical binding]; other site 1310114000927 potential frameshift: common BLAST hit: gi|449062422|ref|YP_007429505.1| thiamine biosynthesis protein ThiC 1310114000928 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310114000929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310114000930 motif II; other site 1310114000931 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310114000932 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310114000933 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1310114000934 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1310114000935 putative catalytic site [active] 1310114000936 putative phosphate binding site [ion binding]; other site 1310114000937 active site 1310114000938 metal binding site A [ion binding]; metal-binding site 1310114000939 DNA binding site [nucleotide binding] 1310114000940 putative AP binding site [nucleotide binding]; other site 1310114000941 putative metal binding site B [ion binding]; other site 1310114000942 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1310114000943 active site 1310114000944 catalytic residues [active] 1310114000945 metal binding site [ion binding]; metal-binding site 1310114000946 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1310114000947 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310114000948 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1310114000949 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1310114000950 E-class dimer interface [polypeptide binding]; other site 1310114000951 P-class dimer interface [polypeptide binding]; other site 1310114000952 active site 1310114000953 Cu2+ binding site [ion binding]; other site 1310114000954 Zn2+ binding site [ion binding]; other site 1310114000955 carboxylate-amine ligase; Provisional; Region: PRK13517 1310114000956 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1310114000957 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1310114000958 potential frameshift: common BLAST hit: gi|471336258|ref|YP_007608971.1| putative ATPase 1310114000959 potential frameshift: common BLAST hit: gi|433629519|ref|YP_007263147.1| Putative conserved ATPase 1310114000960 potential frameshift: common BLAST hit: gi|433625526|ref|YP_007259155.1| Putative conserved ATPase 1310114000961 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1310114000962 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1310114000963 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1310114000964 potential frameshift: common BLAST hit: gi|471336261|ref|YP_007608974.1| molybdopterin biosynthesis protein 1310114000965 short chain dehydrogenase; Provisional; Region: PRK06197 1310114000966 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1310114000967 putative NAD(P) binding site [chemical binding]; other site 1310114000968 active site 1310114000969 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1310114000970 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1310114000971 ring oligomerisation interface [polypeptide binding]; other site 1310114000972 ATP/Mg binding site [chemical binding]; other site 1310114000973 stacking interactions; other site 1310114000974 hinge regions; other site 1310114000975 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000976 PPE family; Region: PPE; pfam00823 1310114000977 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1310114000978 DinB superfamily; Region: DinB_2; pfam12867 1310114000979 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1310114000980 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1310114000981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114000982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310114000983 DNA binding residues [nucleotide binding] 1310114000984 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1310114000985 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114000986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114000987 S-adenosylmethionine binding site [chemical binding]; other site 1310114000988 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1310114000989 Transport protein; Region: actII; TIGR00833 1310114000990 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310114000991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114000992 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114000993 PPE family; Region: PPE; pfam00823 1310114000994 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1310114000995 enoyl-CoA hydratase; Provisional; Region: PRK12478 1310114000996 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114000997 substrate binding site [chemical binding]; other site 1310114000998 oxyanion hole (OAH) forming residues; other site 1310114000999 trimer interface [polypeptide binding]; other site 1310114001000 PemK-like protein; Region: PemK; pfam02452 1310114001001 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1310114001002 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310114001003 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310114001004 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310114001005 NAD(P) binding site [chemical binding]; other site 1310114001006 catalytic residues [active] 1310114001007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1310114001008 potential frameshift: common BLAST hit: gi|471336287|ref|YP_007609000.1| dihydrolipoamide dehydrogenase 1310114001009 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310114001010 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1310114001011 potential frameshift: common BLAST hit: gi|433640585|ref|YP_007286344.1| Putative transcriptional regulatory protein 1310114001012 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1310114001013 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1310114001014 active site 1310114001015 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310114001016 active site 2 [active] 1310114001017 isocitrate lyase; Provisional; Region: PRK15063 1310114001018 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1310114001019 oligomerization interface [polypeptide binding]; other site 1310114001020 active site 1310114001021 metal binding site [ion binding]; metal-binding site 1310114001022 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1310114001023 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1310114001024 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1310114001025 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114001026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001027 S-adenosylmethionine binding site [chemical binding]; other site 1310114001028 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114001029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310114001030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001031 S-adenosylmethionine binding site [chemical binding]; other site 1310114001032 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1310114001033 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310114001034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114001035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114001036 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1310114001037 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310114001038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310114001039 non-specific DNA binding site [nucleotide binding]; other site 1310114001040 salt bridge; other site 1310114001041 sequence-specific DNA binding site [nucleotide binding]; other site 1310114001042 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1310114001043 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1310114001044 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 1310114001045 catalytic residue [active] 1310114001046 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1310114001047 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1310114001048 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1310114001049 active site 1310114001050 catalytic triad [active] 1310114001051 dimer interface [polypeptide binding]; other site 1310114001052 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1310114001053 potential frameshift: common BLAST hit: gi|471336308|ref|YP_007609021.1| UDP-N-acetylenolpyruvoylglucosamine reductase 1310114001054 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1310114001055 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1310114001056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310114001057 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1310114001058 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310114001059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114001060 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1310114001061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114001062 NAD(P) binding site [chemical binding]; other site 1310114001063 active site 1310114001064 potential frameshift: common BLAST hit: gi|471336311|ref|YP_007609024.1| transcriptional regulator 1310114001065 potential frameshift: common BLAST hit: gi|471336311|ref|YP_007609024.1| transcriptional regulator 1310114001066 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1310114001067 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1310114001068 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1310114001069 L-lysine exporter; Region: 2a75; TIGR00948 1310114001070 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310114001071 catalytic core [active] 1310114001072 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1310114001073 potential frameshift: common BLAST hit: gi|449062492|ref|YP_007429575.1| two component sensor histidine kinase senX3 1310114001074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114001075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114001076 active site 1310114001077 phosphorylation site [posttranslational modification] 1310114001078 intermolecular recognition site; other site 1310114001079 dimerization interface [polypeptide binding]; other site 1310114001080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114001081 DNA binding site [nucleotide binding] 1310114001082 potential frameshift: common BLAST hit: gi|471336318|ref|YP_007609031.1| oxidoreductase 1310114001083 FCD domain; Region: FCD; cl11656 1310114001084 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1310114001085 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1310114001086 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1310114001087 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1310114001088 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1310114001089 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1310114001090 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1310114001091 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1310114001092 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1310114001093 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1310114001094 DNA binding domain, excisionase family; Region: excise; TIGR01764 1310114001095 potential frameshift: common BLAST hit: gi|471336330|ref|YP_007609043.1| UDP-glucose 4-epimerase 1310114001096 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114001097 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1310114001098 putative acyl-acceptor binding pocket; other site 1310114001099 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114001100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310114001101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001102 S-adenosylmethionine binding site [chemical binding]; other site 1310114001103 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1310114001104 active site 1310114001105 catalytic site [active] 1310114001106 potential frameshift: common BLAST hit: gi|15839898|ref|NP_334935.1| SerB family protein 1310114001107 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310114001108 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310114001109 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1310114001110 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1310114001111 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1310114001112 tRNA; other site 1310114001113 putative tRNA binding site [nucleotide binding]; other site 1310114001114 putative NADP binding site [chemical binding]; other site 1310114001115 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1310114001116 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1310114001117 porphobilinogen deaminase; Provisional; Region: PRK01066 1310114001118 domain interfaces; other site 1310114001119 active site 1310114001120 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1310114001121 active site 1310114001122 SAM binding site [chemical binding]; other site 1310114001123 homodimer interface [polypeptide binding]; other site 1310114001124 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1310114001125 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1310114001126 active site 1310114001127 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 1310114001128 dimer interface [polypeptide binding]; other site 1310114001129 active site 1310114001130 Schiff base residues; other site 1310114001131 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 1310114001132 Schiff base residues; other site 1310114001133 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114001134 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114001135 active site 1310114001136 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310114001137 anti sigma factor interaction site; other site 1310114001138 regulatory phosphorylation site [posttranslational modification]; other site 1310114001139 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310114001140 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310114001141 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1310114001142 active site 1310114001143 catalytic triad [active] 1310114001144 oxyanion hole [active] 1310114001145 potential frameshift: common BLAST hit: gi|433640642|ref|YP_007286401.1| Conserved membrane protein of unknown function 1310114001146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001147 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310114001148 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1310114001149 potential frameshift: common BLAST hit: gi|397672322|ref|YP_006513857.1| glutamate-1-semialdehyde 2,1-aminomutase 1310114001150 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1310114001151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310114001152 catalytic residues [active] 1310114001153 potential frameshift: common BLAST hit: gi|471336358|ref|YP_007609071.1| cytochrome C-type biogenesis protein 1310114001154 potential frameshift: common BLAST hit: gi|471336359|ref|YP_007609072.1| transmembrane protein 1310114001155 potential frameshift: common BLAST hit: gi|471336359|ref|YP_007609072.1| transmembrane protein 1310114001156 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1310114001157 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310114001158 P-loop; other site 1310114001159 Magnesium ion binding site [ion binding]; other site 1310114001160 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310114001161 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1310114001162 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1310114001163 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1310114001164 dimer interface [polypeptide binding]; other site 1310114001165 active site 1310114001166 CoA binding pocket [chemical binding]; other site 1310114001167 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1310114001168 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310114001169 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1310114001170 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1310114001171 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310114001172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114001173 NAD(P) binding site [chemical binding]; other site 1310114001174 active site 1310114001175 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1310114001176 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1310114001177 Ligand binding site; other site 1310114001178 Putative Catalytic site; other site 1310114001179 DXD motif; other site 1310114001180 potential frameshift: common BLAST hit: gi|471336374|ref|YP_007609087.1| O-succinylbenzoic acid-CoA ligase 1310114001181 potential frameshift: common BLAST hit: gi|471336374|ref|YP_007609087.1| O-succinylbenzoic acid-CoA ligase 1310114001182 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1310114001183 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1310114001184 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310114001185 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1310114001186 active site 1310114001187 short chain dehydrogenase; Provisional; Region: PRK05866 1310114001188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114001189 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114001190 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1310114001191 substrate binding site [chemical binding]; other site 1310114001192 oxyanion hole (OAH) forming residues; other site 1310114001193 trimer interface [polypeptide binding]; other site 1310114001194 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1310114001195 putative active site [active] 1310114001196 homotetrameric interface [polypeptide binding]; other site 1310114001197 metal binding site [ion binding]; metal-binding site 1310114001198 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1310114001199 acyl-CoA synthetase; Validated; Region: PRK06188 1310114001200 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1310114001201 putative active site [active] 1310114001202 putative CoA binding site [chemical binding]; other site 1310114001203 putative AMP binding site [chemical binding]; other site 1310114001204 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310114001205 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1310114001206 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1310114001207 active site 1310114001208 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1310114001209 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1310114001210 active site 1310114001211 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114001212 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1310114001213 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310114001214 potential frameshift: common BLAST hit: gi|471336388|ref|YP_007609101.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic 1310114001215 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1310114001216 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310114001217 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1310114001218 potential frameshift: common BLAST hit: gi|471336391|ref|YP_007609104.1| ubiquinone/menaquinone biosynthesismethyltransferase 1310114001219 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114001220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001221 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310114001222 S-adenosylmethionine binding site [chemical binding]; other site 1310114001223 potential frameshift: common BLAST hit: gi|449062570|ref|YP_007429653.1| oxidoreductase 1310114001224 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1310114001225 substrate binding pocket [chemical binding]; other site 1310114001226 aspartate-rich region 1; other site 1310114001227 potential frameshift: common BLAST hit: gi|449062571|ref|YP_007429654.1| polyprenyl-diphosphate synthase 1310114001228 potential frameshift: common BLAST hit: gi|471336396|ref|YP_007609109.1| heat shock protein 1310114001229 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1310114001230 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1310114001231 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1310114001232 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114001233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310114001234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1310114001235 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1310114001236 O-methyltransferase; Region: Methyltransf_2; pfam00891 1310114001237 potential frameshift: common BLAST hit: gi|449062577|ref|YP_007429660.1| cytochrome p450 135b1 cyp135B1 1310114001238 potential frameshift: common BLAST hit: gi|449062577|ref|YP_007429660.1| cytochrome p450 135b1 cyp135B1 1310114001239 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1310114001240 ATP cone domain; Region: ATP-cone; pfam03477 1310114001241 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1310114001242 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1310114001243 active site 1310114001244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310114001245 active site 1310114001246 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310114001247 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1310114001248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1310114001249 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1310114001250 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1310114001251 active site 1310114001252 potential frameshift: common BLAST hit: gi|397672373|ref|YP_006513908.1| poly-gamma-glutamate synthesis protein 1310114001253 hypothetical protein; Provisional; Region: PRK07588 1310114001254 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310114001255 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1310114001256 putative hydrophobic ligand binding site [chemical binding]; other site 1310114001257 TIGR03086 family protein; Region: TIGR03086 1310114001258 TIGR03086 family protein; Region: TIGR03086 1310114001259 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310114001260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310114001261 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310114001262 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1310114001263 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1310114001264 Protein of unknown function DUF82; Region: DUF82; pfam01927 1310114001265 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114001266 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310114001267 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1310114001268 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1310114001269 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1310114001270 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1310114001271 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310114001272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310114001273 DNA-binding site [nucleotide binding]; DNA binding site 1310114001274 FCD domain; Region: FCD; pfam07729 1310114001275 potential frameshift: common BLAST hit: gi|471336424|ref|YP_007609137.1| integral membrane protein 1310114001276 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310114001277 Permease; Region: Permease; pfam02405 1310114001278 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114001279 mce related protein; Region: MCE; pfam02470 1310114001280 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310114001281 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1310114001282 mce related protein; Region: MCE; pfam02470 1310114001283 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310114001284 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114001285 mce related protein; Region: MCE; pfam02470 1310114001286 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114001287 mce related protein; Region: MCE; pfam02470 1310114001288 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310114001289 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114001290 mce related protein; Region: MCE; pfam02470 1310114001291 potential frameshift: common BLAST hit: gi|449062606|ref|YP_007429689.1| MCE-family protein mce2F 1310114001292 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1310114001293 oligomeric interface; other site 1310114001294 putative active site [active] 1310114001295 homodimer interface [polypeptide binding]; other site 1310114001296 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310114001297 potential frameshift: common BLAST hit: gi|397672397|ref|YP_006513932.1| ATPase AAA+ superfamily protein 1310114001298 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1310114001299 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1310114001300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310114001301 dimerization interface [polypeptide binding]; other site 1310114001302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114001303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114001304 active site 1310114001305 phosphorylation site [posttranslational modification] 1310114001306 intermolecular recognition site; other site 1310114001307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114001308 DNA binding site [nucleotide binding] 1310114001309 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1310114001310 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1310114001311 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310114001312 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1310114001313 catalytic residues [active] 1310114001314 catalytic nucleophile [active] 1310114001315 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310114001316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310114001317 Probable transposase; Region: OrfB_IS605; pfam01385 1310114001318 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1310114001319 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1310114001320 putative active site [active] 1310114001321 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310114001322 putative active site [active] 1310114001323 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1310114001324 nucleotide binding site/active site [active] 1310114001325 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1310114001326 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1310114001327 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1310114001328 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114001329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1310114001330 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1310114001331 putative active site [active] 1310114001332 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1310114001333 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310114001334 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1310114001335 potential frameshift: common BLAST hit: gi|471336472|ref|YP_007609185.1| exonuclease V alpha chain 1310114001336 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1310114001337 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1310114001338 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1310114001339 potential frameshift: common BLAST hit: gi|471336473|ref|YP_007609186.1| exonuclease V beta chain 1310114001340 potential frameshift: common BLAST hit: gi|471336473|ref|YP_007609186.1| exonuclease V beta chain 1310114001341 potential frameshift: common BLAST hit: gi|449062646|ref|YP_007429729.1| exonuclease V (gamma chain) recC 1310114001342 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1310114001343 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1310114001344 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310114001345 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114001346 substrate binding site [chemical binding]; other site 1310114001347 oxyanion hole (OAH) forming residues; other site 1310114001348 trimer interface [polypeptide binding]; other site 1310114001349 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1310114001350 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310114001351 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1310114001352 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1310114001353 active site 1310114001354 catalytic site [active] 1310114001355 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1310114001356 active site 1310114001357 catalytic site [active] 1310114001358 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1310114001359 active site 1310114001360 catalytic site [active] 1310114001361 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1310114001362 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1310114001363 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1310114001364 putative homodimer interface [polypeptide binding]; other site 1310114001365 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1310114001366 heterodimer interface [polypeptide binding]; other site 1310114001367 homodimer interface [polypeptide binding]; other site 1310114001368 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1310114001369 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1310114001370 23S rRNA interface [nucleotide binding]; other site 1310114001371 L7/L12 interface [polypeptide binding]; other site 1310114001372 putative thiostrepton binding site; other site 1310114001373 L25 interface [polypeptide binding]; other site 1310114001374 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1310114001375 mRNA/rRNA interface [nucleotide binding]; other site 1310114001376 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114001377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001378 S-adenosylmethionine binding site [chemical binding]; other site 1310114001379 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114001380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310114001381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001382 S-adenosylmethionine binding site [chemical binding]; other site 1310114001383 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114001384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310114001385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001386 S-adenosylmethionine binding site [chemical binding]; other site 1310114001387 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114001388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310114001389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001390 S-adenosylmethionine binding site [chemical binding]; other site 1310114001391 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114001392 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310114001393 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1310114001394 ABC1 family; Region: ABC1; cl17513 1310114001395 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1310114001396 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1310114001397 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1310114001398 potential frameshift: common BLAST hit: gi|397672454|ref|YP_006513989.1| alpha-mannosidase 1310114001399 potential frameshift: common BLAST hit: gi|397672454|ref|YP_006513989.1| alpha-mannosidase 1310114001400 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1310114001401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310114001402 potential frameshift: common BLAST hit: gi|471336497|ref|YP_007609210.1| 50S ribosomal protein L10 1310114001403 potential frameshift: common BLAST hit: gi|386003684|ref|YP_005921963.1| 50S ribosomal protein L7/L12 1310114001404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114001405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114001406 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1310114001407 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1310114001408 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1310114001409 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1310114001410 Walker A/P-loop; other site 1310114001411 ATP binding site [chemical binding]; other site 1310114001412 Q-loop/lid; other site 1310114001413 ABC transporter signature motif; other site 1310114001414 Walker B; other site 1310114001415 D-loop; other site 1310114001416 H-loop/switch region; other site 1310114001417 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310114001418 putative active site [active] 1310114001419 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310114001420 CAAX protease self-immunity; Region: Abi; cl00558 1310114001421 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310114001422 potential frameshift: common BLAST hit: gi|433640783|ref|YP_007286542.1| Conserved protein of unknown function, possible antitoxin 1310114001423 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1310114001424 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1310114001425 Sulfatase; Region: Sulfatase; pfam00884 1310114001426 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1310114001427 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310114001428 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310114001429 putative active site [active] 1310114001430 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1310114001431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1310114001432 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1310114001433 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1310114001434 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1310114001435 RPB10 interaction site [polypeptide binding]; other site 1310114001436 RPB1 interaction site [polypeptide binding]; other site 1310114001437 RPB11 interaction site [polypeptide binding]; other site 1310114001438 RPB3 interaction site [polypeptide binding]; other site 1310114001439 RPB12 interaction site [polypeptide binding]; other site 1310114001440 potential frameshift: common BLAST hit: gi|433625758|ref|YP_007259387.1| DNA-directed RNA polymerase (beta' chain) RpoC (transcriptase beta' 1310114001441 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1310114001442 endonuclease IV; Provisional; Region: PRK01060 1310114001443 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1310114001444 AP (apurinic/apyrimidinic) site pocket; other site 1310114001445 DNA interaction; other site 1310114001446 Metal-binding active site; metal-binding site 1310114001447 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1310114001448 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1310114001449 potential frameshift: common BLAST hit: gi|471336519|ref|YP_007609232.1| acyl-CoA dehydrogenase 1310114001450 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310114001451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114001452 substrate binding site [chemical binding]; other site 1310114001453 oxyanion hole (OAH) forming residues; other site 1310114001454 trimer interface [polypeptide binding]; other site 1310114001455 potential frameshift: common BLAST hit: gi|397672482|ref|YP_006514017.1| phenylacetic acid degradation operon negative regulatory protein 1310114001456 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1310114001457 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310114001458 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310114001459 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1310114001460 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1310114001461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114001462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114001463 WHG domain; Region: WHG; pfam13305 1310114001464 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1310114001465 S17 interaction site [polypeptide binding]; other site 1310114001466 S8 interaction site; other site 1310114001467 16S rRNA interaction site [nucleotide binding]; other site 1310114001468 streptomycin interaction site [chemical binding]; other site 1310114001469 23S rRNA interaction site [nucleotide binding]; other site 1310114001470 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1310114001471 30S ribosomal protein S7; Validated; Region: PRK05302 1310114001472 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310114001473 G1 box; other site 1310114001474 GTP/Mg2+ binding site [chemical binding]; other site 1310114001475 G2 box; other site 1310114001476 Switch I region; other site 1310114001477 G3 box; other site 1310114001478 Switch II region; other site 1310114001479 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310114001480 G5 box; other site 1310114001481 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1310114001482 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1310114001483 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1310114001484 elongation factor Tu; Reviewed; Region: PRK00049 1310114001485 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1310114001486 G1 box; other site 1310114001487 GEF interaction site [polypeptide binding]; other site 1310114001488 GTP/Mg2+ binding site [chemical binding]; other site 1310114001489 Switch I region; other site 1310114001490 G2 box; other site 1310114001491 G3 box; other site 1310114001492 Switch II region; other site 1310114001493 G4 box; other site 1310114001494 G5 box; other site 1310114001495 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1310114001496 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1310114001497 Antibiotic Binding Site [chemical binding]; other site 1310114001498 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1310114001499 classical (c) SDRs; Region: SDR_c; cd05233 1310114001500 NAD(P) binding site [chemical binding]; other site 1310114001501 active site 1310114001502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1310114001503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114001504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1310114001505 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1310114001506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114001507 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1310114001508 potential frameshift: common BLAST hit: gi|471336541|ref|YP_007609254.1| coenzyme PQQ synthesis protein E 1310114001509 potential frameshift: common BLAST hit: gi|471336542|ref|YP_007609255.1| L-lactate dehydrogenase (cytochrome) 1310114001510 potential frameshift: common BLAST hit: gi|397672504|ref|YP_006514039.1| creatinine amidohydrolase, mycofactocin system protein 1310114001511 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1310114001512 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1310114001513 Probable Catalytic site; other site 1310114001514 metal-binding site 1310114001515 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1310114001516 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1310114001517 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1310114001518 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1310114001519 potential frameshift: common BLAST hit: gi|471336549|ref|YP_007609262.1| 50S ribosomal protein L3 1310114001520 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1310114001521 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1310114001522 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1310114001523 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1310114001524 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1310114001525 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1310114001526 potential frameshift: common BLAST hit: gi|471336554|ref|YP_007609267.1| 50S ribosomal protein L22 1310114001527 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1310114001528 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1310114001529 G-X-X-G motif; other site 1310114001530 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1310114001531 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1310114001532 23S rRNA interface [nucleotide binding]; other site 1310114001533 5S rRNA interface [nucleotide binding]; other site 1310114001534 putative antibiotic binding site [chemical binding]; other site 1310114001535 L25 interface [polypeptide binding]; other site 1310114001536 L27 interface [polypeptide binding]; other site 1310114001537 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1310114001538 putative translocon interaction site; other site 1310114001539 23S rRNA interface [nucleotide binding]; other site 1310114001540 signal recognition particle (SRP54) interaction site; other site 1310114001541 L23 interface [polypeptide binding]; other site 1310114001542 trigger factor interaction site; other site 1310114001543 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1310114001544 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1310114001545 Sulfatase; Region: Sulfatase; pfam00884 1310114001546 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1310114001547 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1310114001548 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1310114001549 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1310114001550 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1310114001551 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1310114001552 RNA binding site [nucleotide binding]; other site 1310114001553 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1310114001554 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1310114001555 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1310114001556 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1310114001557 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1310114001558 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1310114001559 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1310114001560 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1310114001561 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1310114001562 5S rRNA interface [nucleotide binding]; other site 1310114001563 23S rRNA interface [nucleotide binding]; other site 1310114001564 L5 interface [polypeptide binding]; other site 1310114001565 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1310114001566 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1310114001567 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1310114001568 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1310114001569 23S rRNA binding site [nucleotide binding]; other site 1310114001570 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1310114001571 potential frameshift: common BLAST hit: gi|15840132|ref|NP_335169.1| protease IV 1310114001572 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114001573 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114001574 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114001575 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114001576 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1310114001577 intersubunit interface [polypeptide binding]; other site 1310114001578 active site 1310114001579 Zn2+ binding site [ion binding]; other site 1310114001580 potential frameshift: common BLAST hit: gi|449062751|ref|YP_007429834.1| D-3-phosphoglycerate dehydrogenase 1310114001581 potential frameshift: common BLAST hit: gi|471336577|ref|YP_007609290.1| D-3-phosphoglycerate dehydrogenase 1310114001582 potential frameshift: common BLAST hit: gi|471336578|ref|YP_007609291.1| D-xylulose kinase 1310114001583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1310114001584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310114001585 Coenzyme A binding pocket [chemical binding]; other site 1310114001586 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1310114001587 SecY translocase; Region: SecY; pfam00344 1310114001588 adenylate kinase; Reviewed; Region: adk; PRK00279 1310114001589 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1310114001590 AMP-binding site [chemical binding]; other site 1310114001591 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1310114001592 potential frameshift: common BLAST hit: gi|471336583|ref|YP_007609296.1| methionine aminopeptidase 1310114001593 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1310114001594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114001595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310114001596 DNA binding residues [nucleotide binding] 1310114001597 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310114001598 MarR family; Region: MarR; pfam01047 1310114001599 TIGR03086 family protein; Region: TIGR03086 1310114001600 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1310114001601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310114001602 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310114001603 Helix-turn-helix domain; Region: HTH_17; pfam12728 1310114001604 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1310114001605 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1310114001606 potential frameshift: common BLAST hit: gi|57116773|ref|YP_177750.1| PE-PGRS family protein PE_PGRS9 1310114001607 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114001608 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310114001609 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1310114001610 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310114001611 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114001612 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114001613 active site 1310114001614 potential frameshift: common BLAST hit: gi|471336609|ref|YP_007609322.1| methylmalonate-semialdehyde dehydrogenase 1310114001615 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1310114001616 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114001617 PPE family; Region: PPE; pfam00823 1310114001618 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114001619 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114001620 PPE family; Region: PPE; pfam00823 1310114001621 Helix-turn-helix domain; Region: HTH_28; pfam13518 1310114001622 Winged helix-turn helix; Region: HTH_29; pfam13551 1310114001623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114001625 active site 1310114001626 phosphorylation site [posttranslational modification] 1310114001627 intermolecular recognition site; other site 1310114001628 dimerization interface [polypeptide binding]; other site 1310114001629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114001630 DNA binding site [nucleotide binding] 1310114001631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310114001632 dimer interface [polypeptide binding]; other site 1310114001633 phosphorylation site [posttranslational modification] 1310114001634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114001635 ATP binding site [chemical binding]; other site 1310114001636 Mg2+ binding site [ion binding]; other site 1310114001637 G-X-G motif; other site 1310114001638 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1310114001639 nucleotide binding site/active site [active] 1310114001640 HIT family signature motif; other site 1310114001641 catalytic residue [active] 1310114001642 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1310114001643 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1310114001644 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1310114001645 NAD binding site [chemical binding]; other site 1310114001646 catalytic Zn binding site [ion binding]; other site 1310114001647 substrate binding site [chemical binding]; other site 1310114001648 structural Zn binding site [ion binding]; other site 1310114001649 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1310114001650 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1310114001651 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1310114001652 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114001653 Cytochrome P450; Region: p450; cl12078 1310114001654 short chain dehydrogenase; Provisional; Region: PRK07775 1310114001655 classical (c) SDRs; Region: SDR_c; cd05233 1310114001656 NAD(P) binding site [chemical binding]; other site 1310114001657 active site 1310114001658 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114001659 Cytochrome P450; Region: p450; cl12078 1310114001660 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114001661 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1310114001662 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310114001663 NAD binding site [chemical binding]; other site 1310114001664 catalytic residues [active] 1310114001665 short chain dehydrogenase; Provisional; Region: PRK07774 1310114001666 classical (c) SDRs; Region: SDR_c; cd05233 1310114001667 NAD(P) binding site [chemical binding]; other site 1310114001668 active site 1310114001669 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310114001670 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1310114001671 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1310114001672 potential frameshift: common BLAST hit: gi|471336629|ref|YP_007609342.1| phosphoribosylamine-glycine ligase 1310114001673 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1310114001674 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1310114001675 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1310114001676 S-formylglutathione hydrolase; Region: PLN02442 1310114001677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1310114001678 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1310114001679 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1310114001680 Lyase; Region: Lyase_1; pfam00206 1310114001681 tetramer interface [polypeptide binding]; other site 1310114001682 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114001683 Cytochrome P450; Region: p450; cl12078 1310114001684 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1310114001685 ATP binding site [chemical binding]; other site 1310114001686 active site 1310114001687 substrate binding site [chemical binding]; other site 1310114001688 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1310114001689 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310114001690 WHG domain; Region: WHG; pfam13305 1310114001691 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310114001692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114001693 putative substrate translocation pore; other site 1310114001694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114001695 Predicted deacetylase [General function prediction only]; Region: COG3233 1310114001696 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1310114001697 putative active site [active] 1310114001698 putative Zn binding site [ion binding]; other site 1310114001699 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1310114001700 FAD binding domain; Region: FAD_binding_2; pfam00890 1310114001701 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1310114001702 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1310114001703 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1310114001704 putative active site [active] 1310114001705 catalytic triad [active] 1310114001706 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310114001707 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1310114001708 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1310114001709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310114001710 DNA-binding site [nucleotide binding]; DNA binding site 1310114001711 UTRA domain; Region: UTRA; pfam07702 1310114001712 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1310114001713 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310114001714 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1310114001715 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1310114001716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114001717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114001718 Transposase; Region: HTH_Tnp_1; cl17663 1310114001719 putative transposase OrfB; Reviewed; Region: PHA02517 1310114001720 HTH-like domain; Region: HTH_21; pfam13276 1310114001721 Integrase core domain; Region: rve; pfam00665 1310114001722 Integrase core domain; Region: rve_3; pfam13683 1310114001723 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310114001724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310114001725 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310114001726 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1310114001727 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1310114001728 potential frameshift: common BLAST hit: gi|471336660|ref|YP_007609373.1| putative aminopeptidase 2 1310114001729 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1310114001730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310114001731 potential frameshift: common BLAST hit: gi|471336663|ref|YP_007609376.1| phosphoribosylformylglycinamidine synthase II 1310114001732 potential frameshift: common BLAST hit: gi|471336663|ref|YP_007609376.1| phosphoribosylformylglycinamidine synthase II 1310114001733 potential frameshift: common BLAST hit: gi|449062832|ref|YP_007429915.1| phosphoribosylformylglycinamidine synthase II purL 1310114001734 CAAX protease self-immunity; Region: Abi; pfam02517 1310114001735 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1310114001736 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1310114001737 active site 1310114001738 metal binding site [ion binding]; metal-binding site 1310114001739 hexamer interface [polypeptide binding]; other site 1310114001740 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1310114001741 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1310114001742 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1310114001743 active site 1310114001744 tetramer interface [polypeptide binding]; other site 1310114001745 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310114001746 active site 1310114001747 potential frameshift: common BLAST hit: gi|471336668|ref|YP_007609381.1| phosphoribosylaminoimidazole synthetase 1310114001748 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1310114001749 potential frameshift: common BLAST hit: gi|397672625|ref|YP_006514160.1| folate-binding protein YgfZ 1310114001750 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1310114001751 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1310114001752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114001753 catalytic residue [active] 1310114001754 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1310114001755 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1310114001756 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1310114001757 heme-binding site [chemical binding]; other site 1310114001758 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1310114001759 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310114001760 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310114001761 active site residue [active] 1310114001762 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310114001763 active site residue [active] 1310114001764 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310114001765 catalytic residues [active] 1310114001766 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1310114001767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114001768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114001769 DNA binding site [nucleotide binding] 1310114001770 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1310114001771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310114001772 Coenzyme A binding pocket [chemical binding]; other site 1310114001773 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1310114001774 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1310114001775 Walker A/P-loop; other site 1310114001776 ATP binding site [chemical binding]; other site 1310114001777 Q-loop/lid; other site 1310114001778 ABC transporter signature motif; other site 1310114001779 Walker B; other site 1310114001780 D-loop; other site 1310114001781 H-loop/switch region; other site 1310114001782 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1310114001783 PhoU domain; Region: PhoU; pfam01895 1310114001784 PhoU domain; Region: PhoU; pfam01895 1310114001785 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1310114001786 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310114001787 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1310114001788 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1310114001789 FMN binding site [chemical binding]; other site 1310114001790 active site 1310114001791 catalytic residues [active] 1310114001792 substrate binding site [chemical binding]; other site 1310114001793 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1310114001794 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1310114001795 homodimer interface [polypeptide binding]; other site 1310114001796 putative substrate binding pocket [chemical binding]; other site 1310114001797 diiron center [ion binding]; other site 1310114001798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114001799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1310114001800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114001801 dimerization interface [polypeptide binding]; other site 1310114001802 putative DNA binding site [nucleotide binding]; other site 1310114001803 putative Zn2+ binding site [ion binding]; other site 1310114001804 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1310114001805 dimer interface [polypeptide binding]; other site 1310114001806 catalytic motif [active] 1310114001807 nucleoside/Zn binding site; other site 1310114001808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310114001809 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114001810 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114001811 TIGR04255 family protein; Region: sporadTIGR04255 1310114001812 PE family; Region: PE; pfam00934 1310114001813 potential frameshift: common BLAST hit: gi|148822040|ref|YP_001286794.1| PE-PGRS family protein 1310114001814 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310114001815 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1310114001816 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1310114001817 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 1310114001818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114001819 S-adenosylmethionine binding site [chemical binding]; other site 1310114001820 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1310114001821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310114001822 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1310114001823 tetramer interface [polypeptide binding]; other site 1310114001824 TPP-binding site [chemical binding]; other site 1310114001825 heterodimer interface [polypeptide binding]; other site 1310114001826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310114001827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114001828 active site 1310114001829 intermolecular recognition site; other site 1310114001830 dimerization interface [polypeptide binding]; other site 1310114001831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310114001832 dimerization interface [polypeptide binding]; other site 1310114001833 DNA binding residues [nucleotide binding] 1310114001834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310114001835 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1310114001836 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1310114001837 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1310114001838 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1310114001839 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1310114001840 potential frameshift: common BLAST hit: gi|471336711|ref|YP_007609424.1| cysteine synthase A 1310114001841 potential frameshift: common BLAST hit: gi|471336712|ref|YP_007609425.1| integral membrane transport protein 1310114001842 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1310114001843 short chain dehydrogenase; Provisional; Region: PRK05876 1310114001844 classical (c) SDRs; Region: SDR_c; cd05233 1310114001845 NAD(P) binding site [chemical binding]; other site 1310114001846 active site 1310114001847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114001848 potential frameshift: common BLAST hit: gi|471336716|ref|YP_007609429.1| pyruvate or indole-3-pyruvate decarboxylase 1310114001849 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310114001850 putative hydrophobic ligand binding site [chemical binding]; other site 1310114001851 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310114001852 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310114001853 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310114001854 putative hydrophobic ligand binding site [chemical binding]; other site 1310114001855 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310114001856 putative hydrophobic ligand binding site [chemical binding]; other site 1310114001857 aminotransferase; Validated; Region: PRK07777 1310114001858 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310114001859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114001860 homodimer interface [polypeptide binding]; other site 1310114001861 catalytic residue [active] 1310114001862 potential frameshift: common BLAST hit: gi|449062892|ref|YP_007429975.1| acetyl-CoA acetyltransferase 1310114001863 potential frameshift: common BLAST hit: gi|397672675|ref|YP_006514210.1| acetyl-CoA C-acetyltransferase 1310114001864 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1310114001865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114001866 substrate binding site [chemical binding]; other site 1310114001867 oxyanion hole (OAH) forming residues; other site 1310114001868 trimer interface [polypeptide binding]; other site 1310114001869 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1310114001870 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1310114001871 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1310114001872 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310114001873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310114001874 ATP binding site [chemical binding]; other site 1310114001875 putative Mg++ binding site [ion binding]; other site 1310114001876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310114001877 nucleotide binding region [chemical binding]; other site 1310114001878 ATP-binding site [chemical binding]; other site 1310114001879 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1310114001880 trimer interface [polypeptide binding]; other site 1310114001881 dimer interface [polypeptide binding]; other site 1310114001882 putative active site [active] 1310114001883 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1310114001884 MPT binding site; other site 1310114001885 trimer interface [polypeptide binding]; other site 1310114001886 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1310114001887 MoaE homodimer interface [polypeptide binding]; other site 1310114001888 MoaD interaction [polypeptide binding]; other site 1310114001889 active site residues [active] 1310114001890 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310114001891 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1310114001892 MoaE interaction surface [polypeptide binding]; other site 1310114001893 MoeB interaction surface [polypeptide binding]; other site 1310114001894 thiocarboxylated glycine; other site 1310114001895 potential frameshift: common BLAST hit: gi|471336732|ref|YP_007609445.1| molybdenum cofactor biosynthesis protein A 1310114001896 potential frameshift: common BLAST hit: gi|471336732|ref|YP_007609445.1| molybdenum cofactor biosynthesis protein A 1310114001897 hypothetical protein; Provisional; Region: PRK11770 1310114001898 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1310114001899 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1310114001900 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1310114001901 DNA-binding site [nucleotide binding]; DNA binding site 1310114001902 RNA-binding motif; other site 1310114001903 potential frameshift: common BLAST hit: gi|386003889|ref|YP_005922168.1| PE-PGRS family protein 1310114001904 potential frameshift: common BLAST hit: gi|471336737|ref|YP_007609450.1| acyl-CoA dehydrogenase 1310114001905 FIST N domain; Region: FIST; pfam08495 1310114001906 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1310114001907 H+ Antiporter protein; Region: 2A0121; TIGR00900 1310114001908 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1310114001909 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114001910 PPE family; Region: PPE; pfam00823 1310114001911 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114001912 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114001913 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310114001914 MarR family; Region: MarR; pfam01047 1310114001915 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310114001916 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310114001917 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310114001918 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1310114001919 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1310114001920 potential frameshift: common BLAST hit: gi|471336748|ref|YP_007609461.1| phosphoserine aminotransferase 1310114001921 potential protein location (hypothetical protein) that overlaps protein (phosphoserine aminotransferase) 1310114001922 potential protein location (hypothetical protein) that overlaps protein (phosphoserine aminotransferase) 1310114001923 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1310114001924 potential frameshift: common BLAST hit: gi|471336750|ref|YP_007609463.1| NADPH:adrenodoxin oxidoreductase 1310114001925 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1310114001926 putative dimer interface [polypeptide binding]; other site 1310114001927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310114001928 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1310114001929 putative catalytic site [active] 1310114001930 putative phosphate binding site [ion binding]; other site 1310114001931 putative metal binding site [ion binding]; other site 1310114001932 citrate synthase 2; Provisional; Region: PRK12350 1310114001933 Citrate synthase; Region: Citrate_synt; pfam00285 1310114001934 oxalacetate binding site [chemical binding]; other site 1310114001935 citrylCoA binding site [chemical binding]; other site 1310114001936 coenzyme A binding site [chemical binding]; other site 1310114001937 catalytic triad [active] 1310114001938 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310114001939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310114001940 DNA binding residues [nucleotide binding] 1310114001941 dimerization interface [polypeptide binding]; other site 1310114001942 potential frameshift: common BLAST hit: gi|471336756|ref|YP_007609469.1| LuxR family transcriptional regulator 1310114001943 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310114001944 cyclase homology domain; Region: CHD; cd07302 1310114001945 nucleotidyl binding site; other site 1310114001946 metal binding site [ion binding]; metal-binding site 1310114001947 dimer interface [polypeptide binding]; other site 1310114001948 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114001949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310114001950 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114001951 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114001952 AAA ATPase domain; Region: AAA_16; pfam13191 1310114001953 Predicted ATPase [General function prediction only]; Region: COG3903 1310114001954 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114001955 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114001956 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1310114001957 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1310114001958 dimer interface [polypeptide binding]; other site 1310114001959 active site 1310114001960 citrylCoA binding site [chemical binding]; other site 1310114001961 NADH binding [chemical binding]; other site 1310114001962 cationic pore residues; other site 1310114001963 oxalacetate/citrate binding site [chemical binding]; other site 1310114001964 coenzyme A binding site [chemical binding]; other site 1310114001965 catalytic triad [active] 1310114001966 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1310114001967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310114001968 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1310114001969 BON domain; Region: BON; pfam04972 1310114001970 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1310114001971 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1310114001972 ligand binding site [chemical binding]; other site 1310114001973 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1310114001974 potential frameshift: common BLAST hit: gi|471336768|ref|YP_007609481.1| two component sensor histidine kinase 1310114001975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114001976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114001977 active site 1310114001978 phosphorylation site [posttranslational modification] 1310114001979 intermolecular recognition site; other site 1310114001980 dimerization interface [polypeptide binding]; other site 1310114001981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114001982 DNA binding site [nucleotide binding] 1310114001983 potential frameshift: common BLAST hit: gi|339630969|ref|YP_004722611.1| acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1310114001984 potential frameshift: common BLAST hit: gi|471336770|ref|YP_007609483.1| putative acetyl-coenzyme A carboxylase carboxyltransferase 1310114001985 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310114001986 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114001987 substrate binding site [chemical binding]; other site 1310114001988 oxyanion hole (OAH) forming residues; other site 1310114001989 trimer interface [polypeptide binding]; other site 1310114001990 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1310114001991 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1310114001992 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114001993 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114001994 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1310114001995 potential frameshift: common BLAST hit: gi|471336774|ref|YP_007609487.1| metal cation transporter P-type ATPase 1310114001996 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1310114001997 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310114001998 hydrophobic ligand binding site; other site 1310114001999 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310114002000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310114002001 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310114002002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310114002003 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1310114002004 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1310114002005 potential frameshift: common BLAST hit: gi|449062952|ref|YP_007430035.1| acetyl-CoA acetyltransferase 1310114002006 potential frameshift: common BLAST hit: gi|471336783|ref|YP_007609496.1| PPE family protein 1310114002007 PE family; Region: PE; pfam00934 1310114002008 BCCT family transporter; Region: BCCT; pfam02028 1310114002009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1310114002010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310114002011 Coenzyme A binding pocket [chemical binding]; other site 1310114002012 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114002013 MULE transposase domain; Region: MULE; pfam10551 1310114002014 potential frameshift: common BLAST hit: gi|449062961|ref|YP_007430044.1| resolvase 1310114002015 potential frameshift: common BLAST hit: gi|471336793|ref|YP_007609506.1| transposase 1310114002016 potential frameshift: common BLAST hit: gi|449062962|ref|YP_007430045.1| transposase 1310114002017 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1310114002018 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1310114002019 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1310114002020 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1310114002021 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1310114002022 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1310114002023 potential frameshift: common BLAST hit: gi|471336798|ref|YP_007609511.1| short chain dehydrogenase 1310114002024 potential frameshift: common BLAST hit: gi|471336798|ref|YP_007609511.1| short chain dehydrogenase 1310114002025 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1310114002026 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1310114002027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114002028 dimer interface [polypeptide binding]; other site 1310114002029 conserved gate region; other site 1310114002030 putative PBP binding loops; other site 1310114002031 ABC-ATPase subunit interface; other site 1310114002032 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1310114002033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114002034 dimer interface [polypeptide binding]; other site 1310114002035 conserved gate region; other site 1310114002036 putative PBP binding loops; other site 1310114002037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1310114002038 ABC-ATPase subunit interface; other site 1310114002039 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310114002040 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310114002041 active site 1310114002042 ATP binding site [chemical binding]; other site 1310114002043 substrate binding site [chemical binding]; other site 1310114002044 activation loop (A-loop); other site 1310114002045 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310114002046 NHL repeat; Region: NHL; pfam01436 1310114002047 NHL repeat; Region: NHL; pfam01436 1310114002048 NHL repeat; Region: NHL; pfam01436 1310114002049 NHL repeat; Region: NHL; pfam01436 1310114002050 NHL repeat; Region: NHL; pfam01436 1310114002051 PBP superfamily domain; Region: PBP_like_2; cl17296 1310114002052 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1310114002053 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1310114002054 Walker A/P-loop; other site 1310114002055 ATP binding site [chemical binding]; other site 1310114002056 Q-loop/lid; other site 1310114002057 ABC transporter signature motif; other site 1310114002058 Walker B; other site 1310114002059 D-loop; other site 1310114002060 H-loop/switch region; other site 1310114002061 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1310114002062 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1310114002063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114002064 dimer interface [polypeptide binding]; other site 1310114002065 conserved gate region; other site 1310114002066 putative PBP binding loops; other site 1310114002067 ABC-ATPase subunit interface; other site 1310114002068 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1310114002069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114002070 dimer interface [polypeptide binding]; other site 1310114002071 conserved gate region; other site 1310114002072 putative PBP binding loops; other site 1310114002073 ABC-ATPase subunit interface; other site 1310114002074 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1310114002075 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1310114002076 putative DNA binding site [nucleotide binding]; other site 1310114002077 putative homodimer interface [polypeptide binding]; other site 1310114002078 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1310114002079 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1310114002080 nucleotide binding site [chemical binding]; other site 1310114002081 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1310114002082 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1310114002083 active site 1310114002084 DNA binding site [nucleotide binding] 1310114002085 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1310114002086 DNA binding site [nucleotide binding] 1310114002087 potential frameshift: common BLAST hit: gi|339631001|ref|YP_004722643.1| bifunctional protein: 2-hydroxyhepta-2,4-diene-1,7-dioate 1310114002088 potential frameshift: common BLAST hit: gi|339631001|ref|YP_004722643.1| bifunctional protein: 2-hydroxyhepta-2,4-diene-1,7-dioate 1310114002089 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1310114002090 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114002091 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310114002092 anti sigma factor interaction site; other site 1310114002093 regulatory phosphorylation site [posttranslational modification]; other site 1310114002094 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114002095 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310114002096 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1310114002097 short chain dehydrogenase; Provisional; Region: PRK08251 1310114002098 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1310114002099 putative NAD(P) binding site [chemical binding]; other site 1310114002100 active site 1310114002101 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1310114002102 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1310114002103 active site 1310114002104 dimer interface [polypeptide binding]; other site 1310114002105 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1310114002106 dimer interface [polypeptide binding]; other site 1310114002107 active site 1310114002108 Predicted esterase [General function prediction only]; Region: COG0627 1310114002109 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1310114002110 hypothetical protein; Provisional; Region: PRK07857 1310114002111 potential frameshift: common BLAST hit: gi|449062992|ref|YP_007430075.1| ATP-dependent helicase PcrA 1310114002112 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1310114002113 Peptidase family M23; Region: Peptidase_M23; pfam01551 1310114002114 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1310114002115 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1310114002116 CoA-ligase; Region: Ligase_CoA; pfam00549 1310114002117 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1310114002118 CoA binding domain; Region: CoA_binding; smart00881 1310114002119 CoA-ligase; Region: Ligase_CoA; pfam00549 1310114002120 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1310114002121 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114002122 potential frameshift: common BLAST hit: gi|449062998|ref|YP_007430081.1| integral membrane protein 1310114002123 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1310114002124 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1310114002125 active site 1310114002126 substrate binding site [chemical binding]; other site 1310114002127 cosubstrate binding site; other site 1310114002128 catalytic site [active] 1310114002129 potential frameshift: common BLAST hit: gi|471336829|ref|YP_007609542.1| bifunctionalphosphoribosylaminoimidazolecarboxamideformylt ransferas 1310114002130 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1310114002131 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1310114002132 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1310114002133 putative active site [active] 1310114002134 metal binding site [ion binding]; metal-binding site 1310114002135 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310114002136 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310114002137 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1310114002138 putative homodimer interface [polypeptide binding]; other site 1310114002139 putative homotetramer interface [polypeptide binding]; other site 1310114002140 allosteric switch controlling residues; other site 1310114002141 putative metal binding site [ion binding]; other site 1310114002142 putative homodimer-homodimer interface [polypeptide binding]; other site 1310114002143 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1310114002144 potential frameshift: common BLAST hit: gi|449063014|ref|YP_007430097.1| metal cation transporter P-type ATPase ctpV 1310114002145 potential frameshift: common BLAST hit: gi|449063014|ref|YP_007430097.1| metal cation transporter P-type ATPase ctpV 1310114002146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114002147 substrate binding site [chemical binding]; other site 1310114002148 oxyanion hole (OAH) forming residues; other site 1310114002149 trimer interface [polypeptide binding]; other site 1310114002150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114002151 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1310114002152 active site 1310114002153 potential frameshift: common BLAST hit: gi|385990423|ref|YP_005908721.1| acetyl-/propionyl-CoA carboxylase alpha subunit accA2 1310114002154 potential frameshift: common BLAST hit: gi|385990423|ref|YP_005908721.1| acetyl-/propionyl-CoA carboxylase alpha subunit accA2 1310114002155 potential frameshift: common BLAST hit: gi|433630078|ref|YP_007263706.1| Acetyl-/propionyl-coenzyme A carboxylase alpha chain [Includes: 1310114002156 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310114002157 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310114002158 potential frameshift: common BLAST hit: gi|471336852|ref|YP_007609565.1| acyl-CoA dehydrogenase 1310114002159 potential frameshift: common BLAST hit: gi|397672801|ref|YP_006514336.1| PE-PGRS family protein 1310114002160 PE family; Region: PE; pfam00934 1310114002161 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310114002162 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1310114002163 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1310114002164 potential frameshift: common BLAST hit: gi|385994029|ref|YP_005912327.1| PE PGRS family protein 1310114002165 PE family; Region: PE; pfam00934 1310114002166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114002167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114002168 active site 1310114002169 phosphorylation site [posttranslational modification] 1310114002170 intermolecular recognition site; other site 1310114002171 dimerization interface [polypeptide binding]; other site 1310114002172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114002173 DNA binding site [nucleotide binding] 1310114002174 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1310114002175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310114002176 dimerization interface [polypeptide binding]; other site 1310114002177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310114002178 dimer interface [polypeptide binding]; other site 1310114002179 phosphorylation site [posttranslational modification] 1310114002180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114002181 ATP binding site [chemical binding]; other site 1310114002182 Mg2+ binding site [ion binding]; other site 1310114002183 G-X-G motif; other site 1310114002184 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1310114002185 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310114002186 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1310114002187 MPT binding site; other site 1310114002188 trimer interface [polypeptide binding]; other site 1310114002189 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1310114002190 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1310114002191 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310114002192 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310114002193 Walker A/P-loop; other site 1310114002194 ATP binding site [chemical binding]; other site 1310114002195 Q-loop/lid; other site 1310114002196 ABC transporter signature motif; other site 1310114002197 Walker B; other site 1310114002198 D-loop; other site 1310114002199 H-loop/switch region; other site 1310114002200 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1310114002201 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310114002202 FtsX-like permease family; Region: FtsX; pfam02687 1310114002203 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310114002204 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1310114002205 FtsX-like permease family; Region: FtsX; pfam02687 1310114002206 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1310114002207 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310114002208 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310114002209 substrate binding pocket [chemical binding]; other site 1310114002210 chain length determination region; other site 1310114002211 substrate-Mg2+ binding site; other site 1310114002212 catalytic residues [active] 1310114002213 aspartate-rich region 1; other site 1310114002214 active site lid residues [active] 1310114002215 aspartate-rich region 2; other site 1310114002216 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1310114002217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1310114002218 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1310114002219 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310114002220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310114002221 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1310114002222 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1310114002223 MPT binding site; other site 1310114002224 MoeA C-terminal region (domain IV); Region: MoeA_C; pfam03454 1310114002225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1310114002226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310114002227 potential frameshift: common BLAST hit: gi|471336877|ref|YP_007609590.1| transmembrane protein 1310114002228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114002229 S-adenosylmethionine binding site [chemical binding]; other site 1310114002230 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1310114002231 arginine deiminase; Provisional; Region: PRK01388 1310114002232 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1310114002233 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1310114002234 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1310114002235 Predicted methyltransferases [General function prediction only]; Region: COG0313 1310114002236 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1310114002237 putative SAM binding site [chemical binding]; other site 1310114002238 putative homodimer interface [polypeptide binding]; other site 1310114002239 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1310114002240 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1310114002241 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1310114002242 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1310114002243 active site 1310114002244 HIGH motif; other site 1310114002245 KMSKS motif; other site 1310114002246 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1310114002247 tRNA binding surface [nucleotide binding]; other site 1310114002248 anticodon binding site; other site 1310114002249 potential frameshift: common BLAST hit: gi|449063055|ref|YP_007430138.1| deoxyribonuclease TatD (YjjV protein) 1310114002250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1310114002251 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1310114002252 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1310114002253 G5 domain; Region: G5; pfam07501 1310114002254 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310114002255 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1310114002256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114002257 S-adenosylmethionine binding site [chemical binding]; other site 1310114002258 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611 1310114002259 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1310114002260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114002261 acyl-activating enzyme (AAE) consensus motif; other site 1310114002262 CoA binding site [chemical binding]; other site 1310114002263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114002264 AMP binding site [chemical binding]; other site 1310114002265 CoA binding site [chemical binding]; other site 1310114002266 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1310114002267 putative active site [active] 1310114002268 catalytic residue [active] 1310114002269 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1310114002270 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1310114002271 5S rRNA interface [nucleotide binding]; other site 1310114002272 CTC domain interface [polypeptide binding]; other site 1310114002273 L16 interface [polypeptide binding]; other site 1310114002274 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1310114002275 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1310114002276 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1310114002277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310114002278 active site 1310114002279 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1310114002280 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1310114002281 Substrate binding site; other site 1310114002282 Mg++ binding site; other site 1310114002283 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1310114002284 active site 1310114002285 substrate binding site [chemical binding]; other site 1310114002286 CoA binding site [chemical binding]; other site 1310114002287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114002288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114002289 potential frameshift: common BLAST hit: gi|471336904|ref|YP_007609617.1| transcription-repair coupling factor 1310114002290 potential frameshift: common BLAST hit: gi|471336904|ref|YP_007609617.1| transcription-repair coupling factor 1310114002291 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1310114002292 potential frameshift: common BLAST hit: gi|471336904|ref|YP_007609617.1| transcription-repair coupling factor 1310114002293 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1310114002294 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1310114002295 homodimer interface [polypeptide binding]; other site 1310114002296 metal binding site [ion binding]; metal-binding site 1310114002297 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1310114002298 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1310114002299 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1310114002300 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1310114002301 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1310114002302 metal binding site [ion binding]; metal-binding site 1310114002303 substrate binding pocket [chemical binding]; other site 1310114002304 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1310114002305 Septum formation initiator; Region: DivIC; pfam04977 1310114002306 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1310114002307 potential frameshift: common BLAST hit: gi|397672852|ref|YP_006514387.1| exopolyphosphatase 1310114002308 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1310114002309 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1310114002310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114002311 active site 1310114002312 phosphorylation site [posttranslational modification] 1310114002313 intermolecular recognition site; other site 1310114002314 dimerization interface [polypeptide binding]; other site 1310114002315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114002316 DNA binding site [nucleotide binding] 1310114002317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1310114002318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114002319 ATP binding site [chemical binding]; other site 1310114002320 Mg2+ binding site [ion binding]; other site 1310114002321 G-X-G motif; other site 1310114002322 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1310114002323 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1310114002324 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1310114002325 potential frameshift: common BLAST hit: gi|449063080|ref|YP_007430163.1| potassium-transporting ATPase subunit B 1310114002326 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 1310114002327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310114002328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310114002329 dimer interface [polypeptide binding]; other site 1310114002330 phosphorylation site [posttranslational modification] 1310114002331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114002332 ATP binding site [chemical binding]; other site 1310114002333 Mg2+ binding site [ion binding]; other site 1310114002334 G-X-G motif; other site 1310114002335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114002336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114002337 active site 1310114002338 phosphorylation site [posttranslational modification] 1310114002339 intermolecular recognition site; other site 1310114002340 dimerization interface [polypeptide binding]; other site 1310114002341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114002342 DNA binding site [nucleotide binding] 1310114002343 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310114002344 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1310114002345 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310114002346 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310114002347 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1310114002348 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114002349 PPE family; Region: PPE; pfam00823 1310114002350 PE family; Region: PE; pfam00934 1310114002351 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114002352 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1310114002353 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1310114002354 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1310114002355 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1310114002356 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310114002357 Predicted transcriptional regulator [Transcription]; Region: COG5340 1310114002358 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1310114002359 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1310114002360 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114002361 MULE transposase domain; Region: MULE; pfam10551 1310114002362 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310114002363 MarR family; Region: MarR_2; pfam12802 1310114002364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114002365 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310114002366 NAD(P) binding site [chemical binding]; other site 1310114002367 active site 1310114002368 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1310114002369 Helix-turn-helix domain; Region: HTH_17; pfam12728 1310114002370 Fic/DOC family; Region: Fic; pfam02661 1310114002371 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310114002372 Domain of unknown function (DUF427); Region: DUF427; cl00998 1310114002373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1310114002374 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114002375 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310114002376 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1310114002377 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1310114002378 dimer interface [polypeptide binding]; other site 1310114002379 acyl-activating enzyme (AAE) consensus motif; other site 1310114002380 putative active site [active] 1310114002381 AMP binding site [chemical binding]; other site 1310114002382 putative CoA binding site [chemical binding]; other site 1310114002383 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1310114002384 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1310114002385 hydrophobic ligand binding site; other site 1310114002386 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1310114002387 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1310114002388 putative active site [active] 1310114002389 putative dimer interface [polypeptide binding]; other site 1310114002390 Patatin-like phospholipase; Region: Patatin; pfam01734 1310114002391 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1310114002392 nucleophile elbow; other site 1310114002393 hypothetical protein; Provisional; Region: PRK10279 1310114002394 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1310114002395 active site 1310114002396 nucleophile elbow; other site 1310114002397 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1310114002398 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1310114002399 active site residue [active] 1310114002400 PE family; Region: PE; pfam00934 1310114002401 PE family; Region: PE; pfam00934 1310114002402 potential frameshift: common BLAST hit: gi|433630177|ref|YP_007263805.1| Conserved membrane protein of unknown function 1310114002403 potential frameshift: common BLAST hit: gi|471336961|ref|YP_007609674.1| enoyl-CoA hydratase 1310114002404 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1310114002405 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114002406 substrate binding site [chemical binding]; other site 1310114002407 oxyanion hole (OAH) forming residues; other site 1310114002408 trimer interface [polypeptide binding]; other site 1310114002409 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1310114002410 Predicted membrane protein [Function unknown]; Region: COG4760 1310114002411 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1310114002412 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1310114002413 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1310114002414 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310114002415 dimer interface [polypeptide binding]; other site 1310114002416 active site 1310114002417 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1310114002418 catalytic triad [active] 1310114002419 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1310114002420 oxyanion hole [active] 1310114002421 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310114002422 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1310114002423 potential frameshift: common BLAST hit: gi|471336969|ref|YP_007609682.1| cystathionine beta-synthase 1310114002424 potential frameshift: common BLAST hit: gi|471336969|ref|YP_007609682.1| cystathionine beta-synthase 1310114002425 RDD family; Region: RDD; pfam06271 1310114002426 cystathionine gamma-synthase; Provisional; Region: PRK07811 1310114002427 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1310114002428 homodimer interface [polypeptide binding]; other site 1310114002429 substrate-cofactor binding pocket; other site 1310114002430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114002431 catalytic residue [active] 1310114002432 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1310114002433 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1310114002434 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1310114002435 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1310114002436 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1310114002437 potential frameshift: common BLAST hit: gi|392433326|ref|YP_006474370.1| transmembrane protein 1310114002438 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1310114002439 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1310114002440 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1310114002441 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1310114002442 catalytic residue [active] 1310114002443 putative FPP diphosphate binding site; other site 1310114002444 putative FPP binding hydrophobic cleft; other site 1310114002445 dimer interface [polypeptide binding]; other site 1310114002446 putative IPP diphosphate binding site; other site 1310114002447 PE family; Region: PE; pfam00934 1310114002448 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1310114002449 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1310114002450 putative IPP diphosphate binding site; other site 1310114002451 PE family; Region: PE; pfam00934 1310114002452 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1310114002453 PE family; Region: PE; pfam00934 1310114002454 pantothenate kinase; Provisional; Region: PRK05439 1310114002455 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1310114002456 CoA-binding site [chemical binding]; other site 1310114002457 Mg2+-binding site [ion binding]; other site 1310114002458 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1310114002459 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114002460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114002461 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114002462 catalytic residue [active] 1310114002463 potential frameshift: common BLAST hit: gi|433641238|ref|YP_007286997.1| PUTATIVE Serine hydroxymethyltransferase 1 glyA1 1310114002464 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1310114002465 dinuclear metal binding motif [ion binding]; other site 1310114002466 potential frameshift: common BLAST hit: gi|471336994|ref|YP_007609707.1| phosphate starvation-inducible protein 1310114002467 PhoH-like protein; Region: PhoH; cl17668 1310114002468 PhoH-like protein; Region: PhoH; cl17668 1310114002469 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1310114002470 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1310114002471 NodB motif; other site 1310114002472 active site 1310114002473 catalytic site [active] 1310114002474 metal binding site [ion binding]; metal-binding site 1310114002475 potential frameshift: common BLAST hit: gi|471336997|ref|YP_007609710.1| fumarate hydratase 1310114002476 potential frameshift: common BLAST hit: gi|471336998|ref|YP_007609711.1| fructose 1,6-bisphosphatase II 1310114002477 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1310114002478 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1310114002479 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1310114002480 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310114002481 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1310114002482 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310114002483 substrate binding pocket [chemical binding]; other site 1310114002484 catalytic triad [active] 1310114002485 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310114002486 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1310114002487 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1310114002488 putative NAD(P) binding site [chemical binding]; other site 1310114002489 active site 1310114002490 putative substrate binding site [chemical binding]; other site 1310114002491 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1310114002492 potential frameshift: common BLAST hit: gi|449063168|ref|YP_007430251.1| exodeoxyribonuclease VII large subunit 1310114002493 potential frameshift: common BLAST hit: gi|449063168|ref|YP_007430251.1| exodeoxyribonuclease VII large subunit 1310114002494 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1310114002495 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1310114002496 GTP-binding protein YchF; Reviewed; Region: PRK09601 1310114002497 YchF GTPase; Region: YchF; cd01900 1310114002498 G1 box; other site 1310114002499 GTP/Mg2+ binding site [chemical binding]; other site 1310114002500 Switch I region; other site 1310114002501 G2 box; other site 1310114002502 Switch II region; other site 1310114002503 G3 box; other site 1310114002504 G4 box; other site 1310114002505 G5 box; other site 1310114002506 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1310114002507 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1310114002508 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1310114002509 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1310114002510 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1310114002511 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1310114002512 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310114002513 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1310114002514 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310114002515 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114002516 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114002517 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1310114002518 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1310114002519 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1310114002520 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114002521 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114002522 active site 1310114002523 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310114002524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310114002525 non-specific DNA binding site [nucleotide binding]; other site 1310114002526 salt bridge; other site 1310114002527 sequence-specific DNA binding site [nucleotide binding]; other site 1310114002528 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1310114002529 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1310114002530 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1310114002531 citrate synthase; Provisional; Region: PRK14033 1310114002532 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1310114002533 oxalacetate binding site [chemical binding]; other site 1310114002534 citrylCoA binding site [chemical binding]; other site 1310114002535 coenzyme A binding site [chemical binding]; other site 1310114002536 catalytic triad [active] 1310114002537 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1310114002538 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1310114002539 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1310114002540 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1310114002541 substrate binding site [chemical binding]; other site 1310114002542 methionine synthase; Provisional; Region: PRK01207 1310114002543 THF binding site; other site 1310114002544 zinc-binding site [ion binding]; other site 1310114002545 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1310114002546 THF binding site; other site 1310114002547 PPE family; Region: PPE; pfam00823 1310114002548 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310114002549 active site 1310114002550 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1310114002551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114002552 substrate binding site [chemical binding]; other site 1310114002553 oxyanion hole (OAH) forming residues; other site 1310114002554 enoyl-CoA hydratase; Provisional; Region: PRK06494 1310114002555 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1310114002556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1310114002557 CAAX protease self-immunity; Region: Abi; pfam02517 1310114002558 potential frameshift: common BLAST hit: gi|449063203|ref|YP_007430286.1| enoyl-CoA hydratase 1310114002559 enoyl-CoA hydratase; Provisional; Region: PRK06688 1310114002560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114002561 substrate binding site [chemical binding]; other site 1310114002562 oxyanion hole (OAH) forming residues; other site 1310114002563 trimer interface [polypeptide binding]; other site 1310114002564 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310114002565 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310114002566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114002567 NAD(P) binding site [chemical binding]; other site 1310114002568 active site 1310114002569 MMPL family; Region: MMPL; pfam03176 1310114002570 MMPL family; Region: MMPL; pfam03176 1310114002571 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114002572 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114002573 active site 1310114002574 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1310114002575 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1310114002576 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1310114002577 potential frameshift: common BLAST hit: gi|449063215|ref|YP_007430298.1| NAD-dependent deacetylase 1310114002578 Predicted transcriptional regulators [Transcription]; Region: COG1725 1310114002579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310114002580 DNA-binding site [nucleotide binding]; DNA binding site 1310114002581 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114002582 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1310114002583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1310114002584 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1310114002585 uncharacterized HhH-GPD family protein; Region: TIGR03252 1310114002586 minor groove reading motif; other site 1310114002587 helix-hairpin-helix signature motif; other site 1310114002588 mannosyltransferase; Provisional; Region: pimE; PRK13375 1310114002589 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1310114002590 aromatic arch; other site 1310114002591 DCoH dimer interaction site [polypeptide binding]; other site 1310114002592 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1310114002593 DCoH tetramer interaction site [polypeptide binding]; other site 1310114002594 substrate binding site [chemical binding]; other site 1310114002595 potential frameshift: common BLAST hit: gi|471337070|ref|YP_007609783.1| 7,8-dihydro-8-oxoguanine-triphosphatase 1310114002596 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114002597 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1310114002598 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114002599 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114002600 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114002601 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114002602 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1310114002603 molybdopterin cofactor binding site; other site 1310114002604 potential frameshift: common BLAST hit: gi|449063229|ref|YP_007430312.1| respiratory nitrate reductase subunit beta NarH 1310114002605 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1310114002606 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1310114002607 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1310114002608 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1310114002609 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1310114002610 potential frameshift: common BLAST hit: gi|449063233|ref|YP_007430316.1| lipoprotein lpqW 1310114002611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114002612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114002613 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114002614 PPE family; Region: PPE; pfam00823 1310114002615 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114002616 PE family; Region: PE; pfam00934 1310114002617 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1310114002618 PE family; Region: PE; pfam00934 1310114002619 potential frameshift: common BLAST hit: gi|449063241|ref|YP_007430324.1| fbiC 1310114002620 potential frameshift: common BLAST hit: gi|471337085|ref|YP_007609798.1| NADPH dependent 2,4-dienoyl-CoA reductase 1310114002621 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1310114002622 4Fe-4S binding domain; Region: Fer4; pfam00037 1310114002623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310114002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114002625 homodimer interface [polypeptide binding]; other site 1310114002626 catalytic residue [active] 1310114002627 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310114002628 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114002629 active site 1310114002630 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310114002631 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310114002632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114002633 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310114002634 Enoylreductase; Region: PKS_ER; smart00829 1310114002635 NAD(P) binding site [chemical binding]; other site 1310114002636 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1310114002637 KR domain; Region: KR; pfam08659 1310114002638 putative NADP binding site [chemical binding]; other site 1310114002639 active site 1310114002640 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310114002641 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1310114002642 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310114002643 PE-PPE domain; Region: PE-PPE; pfam08237 1310114002644 acyl-CoA synthetase; Validated; Region: PRK05850 1310114002645 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114002646 acyl-activating enzyme (AAE) consensus motif; other site 1310114002647 active site 1310114002648 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1310114002649 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310114002650 NAD(P) binding site [chemical binding]; other site 1310114002651 catalytic residues [active] 1310114002652 Proline dehydrogenase; Region: Pro_dh; cl03282 1310114002653 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1310114002654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114002655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310114002656 DNA binding residues [nucleotide binding] 1310114002657 haloalkane dehalogenase; Provisional; Region: PRK03204 1310114002658 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1310114002659 catalytic site [active] 1310114002660 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310114002661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310114002662 PGAP1-like protein; Region: PGAP1; pfam07819 1310114002663 Cytosolic motility protein; Region: MFP2b; pfam12150 1310114002664 acyl-CoA synthetase; Validated; Region: PRK07787 1310114002665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114002666 acyl-activating enzyme (AAE) consensus motif; other site 1310114002667 AMP binding site [chemical binding]; other site 1310114002668 active site 1310114002669 CoA binding site [chemical binding]; other site 1310114002670 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310114002671 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310114002672 PE family; Region: PE; pfam00934 1310114002673 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114002674 PPE family; Region: PPE; pfam00823 1310114002675 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114002676 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1310114002677 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310114002678 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114002679 MULE transposase domain; Region: MULE; pfam10551 1310114002680 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310114002681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114002682 putative substrate translocation pore; other site 1310114002683 potential frameshift: common BLAST hit: gi|433641349|ref|YP_007287108.1| Putative transferase 1310114002684 potential frameshift: common BLAST hit: gi|471337112|ref|YP_007609825.1| dipeptidase 1310114002685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1310114002686 Walker A motif; other site 1310114002687 ATP binding site [chemical binding]; other site 1310114002688 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1310114002689 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1310114002690 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1310114002691 acyl-activating enzyme (AAE) consensus motif; other site 1310114002692 putative AMP binding site [chemical binding]; other site 1310114002693 putative active site [active] 1310114002694 putative CoA binding site [chemical binding]; other site 1310114002695 dihydropteroate synthase; Region: DHPS; TIGR01496 1310114002696 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1310114002697 substrate binding pocket [chemical binding]; other site 1310114002698 dimer interface [polypeptide binding]; other site 1310114002699 inhibitor binding site; inhibition site 1310114002700 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1310114002701 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310114002702 active site 1310114002703 DivIVA domain; Region: DivI1A_domain; TIGR03544 1310114002704 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1310114002705 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1310114002706 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1310114002707 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310114002708 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 1310114002709 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1310114002710 ligand binding site; other site 1310114002711 oligomer interface; other site 1310114002712 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1310114002713 putative CoA binding site [chemical binding]; other site 1310114002714 PE family; Region: PE; pfam00934 1310114002715 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1310114002716 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1310114002717 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1310114002718 potential frameshift: common BLAST hit: gi|471337129|ref|YP_007609842.1| tetronasin-transport integral membrane proteinABC transporter 1310114002719 potential frameshift: common BLAST hit: gi|471337129|ref|YP_007609842.1| tetronasin-transport integral membrane proteinABC transporter 1310114002720 potential frameshift: common BLAST hit: gi|433641365|ref|YP_007287124.1| Putative tetronasin-transport integral membrane protein ABC 1310114002721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1310114002722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114002723 Q-loop/lid; other site 1310114002724 ABC transporter signature motif; other site 1310114002725 Walker B; other site 1310114002726 D-loop; other site 1310114002727 H-loop/switch region; other site 1310114002728 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1310114002729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114002730 Walker A/P-loop; other site 1310114002731 ATP binding site [chemical binding]; other site 1310114002732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114002733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310114002734 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1310114002735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114002736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310114002737 DNA binding residues [nucleotide binding] 1310114002738 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1310114002739 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310114002740 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1310114002741 protein binding site [polypeptide binding]; other site 1310114002742 sec-independent translocase; Provisional; Region: PRK03100 1310114002743 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1310114002744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310114002745 active site 1310114002746 motif I; other site 1310114002747 motif II; other site 1310114002748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310114002749 potential frameshift: common BLAST hit: gi|397673066|ref|YP_006514601.1| membrane protein 1310114002750 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1310114002751 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1310114002752 Domain of unknown function DUF59; Region: DUF59; cl00941 1310114002753 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1310114002754 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1310114002755 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1310114002756 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1310114002757 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1310114002758 catalytic residue [active] 1310114002759 Predicted membrane protein [Function unknown]; Region: COG4420 1310114002760 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1310114002761 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1310114002762 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1310114002763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114002764 dimer interface [polypeptide binding]; other site 1310114002765 conserved gate region; other site 1310114002766 putative PBP binding loops; other site 1310114002767 ABC-ATPase subunit interface; other site 1310114002768 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310114002769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114002770 dimer interface [polypeptide binding]; other site 1310114002771 conserved gate region; other site 1310114002772 ABC-ATPase subunit interface; other site 1310114002773 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310114002774 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1310114002775 Walker A/P-loop; other site 1310114002776 ATP binding site [chemical binding]; other site 1310114002777 Q-loop/lid; other site 1310114002778 ABC transporter signature motif; other site 1310114002779 Walker B; other site 1310114002780 D-loop; other site 1310114002781 H-loop/switch region; other site 1310114002782 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1310114002783 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1310114002784 oligomer interface [polypeptide binding]; other site 1310114002785 metal binding site [ion binding]; metal-binding site 1310114002786 metal binding site [ion binding]; metal-binding site 1310114002787 putative Cl binding site [ion binding]; other site 1310114002788 basic sphincter; other site 1310114002789 hydrophobic gate; other site 1310114002790 periplasmic entrance; other site 1310114002791 malate dehydrogenase; Provisional; Region: PRK05442 1310114002792 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1310114002793 NAD(P) binding site [chemical binding]; other site 1310114002794 dimer interface [polypeptide binding]; other site 1310114002795 malate binding site [chemical binding]; other site 1310114002796 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310114002797 potential frameshift: common BLAST hit: gi|449063309|ref|YP_007430392.1| PE-PGRS family protein 1310114002798 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1310114002799 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1310114002800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114002801 NAD(P) binding site [chemical binding]; other site 1310114002802 active site 1310114002803 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1310114002804 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1310114002805 potential frameshift: common BLAST hit: gi|378771011|ref|YP_005170744.1| alpha-ketoglutarate decarboxylase 1310114002806 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1310114002807 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310114002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114002809 putative substrate translocation pore; other site 1310114002810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114002811 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1310114002812 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1310114002813 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1310114002814 ATP binding site [chemical binding]; other site 1310114002815 Mg++ binding site [ion binding]; other site 1310114002816 motif III; other site 1310114002817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310114002818 nucleotide binding region [chemical binding]; other site 1310114002819 ATP-binding site [chemical binding]; other site 1310114002820 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1310114002821 putative RNA binding site [nucleotide binding]; other site 1310114002822 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1310114002823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114002824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114002825 potential frameshift: common BLAST hit: gi|397673096|ref|YP_006514631.1| cytochrome P450 130 cyp130 1310114002826 potential frameshift: common BLAST hit: gi|471337171|ref|YP_007609884.1| oxidoreductase 1310114002827 H+ Antiporter protein; Region: 2A0121; TIGR00900 1310114002828 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1310114002829 Fe-S cluster binding site [ion binding]; other site 1310114002830 DNA binding site [nucleotide binding] 1310114002831 active site 1310114002832 hypothetical protein; Validated; Region: PRK05868 1310114002833 hypothetical protein; Provisional; Region: PRK07236 1310114002834 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310114002835 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310114002836 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1310114002837 HIT family signature motif; other site 1310114002838 catalytic residue [active] 1310114002839 potential frameshift: common BLAST hit: gi|471337177|ref|YP_007609890.1| amidase 1310114002840 potential frameshift: common BLAST hit: gi|433634326|ref|YP_007267953.1| putative Adenylate cyclase 1310114002841 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310114002842 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310114002843 active site 1310114002844 ATP binding site [chemical binding]; other site 1310114002845 substrate binding site [chemical binding]; other site 1310114002846 activation loop (A-loop); other site 1310114002847 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310114002848 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1310114002849 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1310114002850 DNA binding site [nucleotide binding] 1310114002851 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310114002852 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310114002853 phosphopeptide binding site; other site 1310114002854 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1310114002855 putative active site [active] 1310114002856 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1310114002857 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1310114002858 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114002859 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310114002860 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1310114002861 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310114002862 Walker A/P-loop; other site 1310114002863 ATP binding site [chemical binding]; other site 1310114002864 Q-loop/lid; other site 1310114002865 ABC transporter signature motif; other site 1310114002866 Walker B; other site 1310114002867 D-loop; other site 1310114002868 H-loop/switch region; other site 1310114002869 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310114002870 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310114002871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114002872 Walker A/P-loop; other site 1310114002873 ATP binding site [chemical binding]; other site 1310114002874 Q-loop/lid; other site 1310114002875 ABC transporter signature motif; other site 1310114002876 Walker B; other site 1310114002877 D-loop; other site 1310114002878 H-loop/switch region; other site 1310114002879 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1310114002880 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1310114002881 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310114002882 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1310114002883 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1310114002884 active site 1310114002885 metal binding site [ion binding]; metal-binding site 1310114002886 DNA binding site [nucleotide binding] 1310114002887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114002888 Walker A/P-loop; other site 1310114002889 ATP binding site [chemical binding]; other site 1310114002890 choline dehydrogenase; Validated; Region: PRK02106 1310114002891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310114002892 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1310114002893 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310114002894 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1310114002895 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1310114002896 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310114002897 Walker A/P-loop; other site 1310114002898 ATP binding site [chemical binding]; other site 1310114002899 Q-loop/lid; other site 1310114002900 ABC transporter signature motif; other site 1310114002901 Walker B; other site 1310114002902 D-loop; other site 1310114002903 H-loop/switch region; other site 1310114002904 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310114002905 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310114002906 Walker A/P-loop; other site 1310114002907 ATP binding site [chemical binding]; other site 1310114002908 Q-loop/lid; other site 1310114002909 ABC transporter signature motif; other site 1310114002910 Walker B; other site 1310114002911 D-loop; other site 1310114002912 H-loop/switch region; other site 1310114002913 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1310114002914 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1310114002915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114002916 dimer interface [polypeptide binding]; other site 1310114002917 conserved gate region; other site 1310114002918 putative PBP binding loops; other site 1310114002919 ABC-ATPase subunit interface; other site 1310114002920 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1310114002921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114002922 dimer interface [polypeptide binding]; other site 1310114002923 conserved gate region; other site 1310114002924 putative PBP binding loops; other site 1310114002925 ABC-ATPase subunit interface; other site 1310114002926 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1310114002927 active site clefts [active] 1310114002928 zinc binding site [ion binding]; other site 1310114002929 dimer interface [polypeptide binding]; other site 1310114002930 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1310114002931 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1310114002932 Active Sites [active] 1310114002933 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1310114002934 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1310114002935 CysD dimerization site [polypeptide binding]; other site 1310114002936 G1 box; other site 1310114002937 putative GEF interaction site [polypeptide binding]; other site 1310114002938 GTP/Mg2+ binding site [chemical binding]; other site 1310114002939 Switch I region; other site 1310114002940 G2 box; other site 1310114002941 G3 box; other site 1310114002942 Switch II region; other site 1310114002943 G4 box; other site 1310114002944 G5 box; other site 1310114002945 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1310114002946 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1310114002947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114002948 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1310114002949 Walker A/P-loop; other site 1310114002950 ligand-binding site [chemical binding]; other site 1310114002951 ATP binding site [chemical binding]; other site 1310114002952 Rrf2 family protein; Region: rrf2_super; TIGR00738 1310114002953 Transcriptional regulator; Region: Rrf2; pfam02082 1310114002954 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1310114002955 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1310114002956 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1310114002957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1310114002958 Putative esterase; Region: Esterase; pfam00756 1310114002959 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1310114002960 Predicted membrane protein [Function unknown]; Region: COG4325 1310114002961 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1310114002962 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114002963 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1310114002964 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1310114002965 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1310114002966 active site 1310114002967 HIGH motif; other site 1310114002968 KMSK motif region; other site 1310114002969 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1310114002970 tRNA binding surface [nucleotide binding]; other site 1310114002971 anticodon binding site; other site 1310114002972 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1310114002973 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1310114002974 active site 1310114002975 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310114002976 substrate binding site [chemical binding]; other site 1310114002977 catalytic residues [active] 1310114002978 dimer interface [polypeptide binding]; other site 1310114002979 potential frameshift: common BLAST hit: gi|471337212|ref|YP_007609925.1| homoserine dehydrogenase 1310114002980 threonine synthase; Reviewed; Region: PRK06721 1310114002981 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1310114002982 homodimer interface [polypeptide binding]; other site 1310114002983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114002984 catalytic residue [active] 1310114002985 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1310114002986 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1310114002987 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1310114002988 RNA binding site [nucleotide binding]; other site 1310114002989 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1310114002990 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1310114002991 multimer interface [polypeptide binding]; other site 1310114002992 Walker A motif; other site 1310114002993 ATP binding site [chemical binding]; other site 1310114002994 Walker B motif; other site 1310114002995 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1310114002996 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1310114002997 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1310114002998 RF-1 domain; Region: RF-1; pfam00472 1310114002999 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1310114003000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003001 S-adenosylmethionine binding site [chemical binding]; other site 1310114003002 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1310114003003 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1310114003004 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1310114003005 Mg++ binding site [ion binding]; other site 1310114003006 putative catalytic motif [active] 1310114003007 substrate binding site [chemical binding]; other site 1310114003008 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1310114003009 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1310114003010 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1310114003011 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1310114003012 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1310114003013 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1310114003014 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1310114003015 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1310114003016 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1310114003017 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1310114003018 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1310114003019 Walker A motif; other site 1310114003020 ATP binding site [chemical binding]; other site 1310114003021 Walker B motif; other site 1310114003022 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1310114003023 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1310114003024 core domain interface [polypeptide binding]; other site 1310114003025 delta subunit interface [polypeptide binding]; other site 1310114003026 epsilon subunit interface [polypeptide binding]; other site 1310114003027 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1310114003028 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1310114003029 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1310114003030 alpha subunit interaction interface [polypeptide binding]; other site 1310114003031 Walker A motif; other site 1310114003032 ATP binding site [chemical binding]; other site 1310114003033 Walker B motif; other site 1310114003034 inhibitor binding site; inhibition site 1310114003035 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1310114003036 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1310114003037 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1310114003038 gamma subunit interface [polypeptide binding]; other site 1310114003039 epsilon subunit interface [polypeptide binding]; other site 1310114003040 LBP interface [polypeptide binding]; other site 1310114003041 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1310114003042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310114003043 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310114003044 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1310114003045 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1310114003046 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1310114003047 hinge; other site 1310114003048 active site 1310114003049 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1310114003050 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1310114003051 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1310114003052 DNA binding site [nucleotide binding] 1310114003053 active site 1310114003054 potential frameshift: common BLAST hit: gi|31792511|ref|NP_855004.1| methylated-DNA--protein-cysteine methyltransferase 1310114003055 potential frameshift: common BLAST hit: gi|449063390|ref|YP_007430473.1| ada regulatory protein alkA 1310114003056 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310114003057 cyclase homology domain; Region: CHD; cd07302 1310114003058 nucleotidyl binding site; other site 1310114003059 metal binding site [ion binding]; metal-binding site 1310114003060 dimer interface [polypeptide binding]; other site 1310114003061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310114003062 dimerization interface [polypeptide binding]; other site 1310114003063 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310114003064 cyclase homology domain; Region: CHD; cd07302 1310114003065 nucleotidyl binding site; other site 1310114003066 metal binding site [ion binding]; metal-binding site 1310114003067 dimer interface [polypeptide binding]; other site 1310114003068 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1310114003069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310114003070 dimerization interface [polypeptide binding]; other site 1310114003071 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310114003072 cyclase homology domain; Region: CHD; cd07302 1310114003073 nucleotidyl binding site; other site 1310114003074 metal binding site [ion binding]; metal-binding site 1310114003075 dimer interface [polypeptide binding]; other site 1310114003076 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1310114003077 hypothetical protein; Provisional; Region: PRK03298 1310114003078 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310114003079 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1310114003080 dimer interface [polypeptide binding]; other site 1310114003081 substrate binding site [chemical binding]; other site 1310114003082 metal binding site [ion binding]; metal-binding site 1310114003083 potential frameshift: common BLAST hit: gi|471337246|ref|YP_007609959.1| acetyl-CoA acetyltransferase 1310114003084 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1310114003085 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1310114003086 PE family; Region: PE; pfam00934 1310114003087 glycogen branching enzyme; Provisional; Region: PRK05402 1310114003088 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1310114003089 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1310114003090 active site 1310114003091 catalytic site [active] 1310114003092 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1310114003093 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1310114003094 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1310114003095 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1310114003096 active site 1310114003097 homodimer interface [polypeptide binding]; other site 1310114003098 catalytic site [active] 1310114003099 acceptor binding site [chemical binding]; other site 1310114003100 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1310114003101 putative homodimer interface [polypeptide binding]; other site 1310114003102 putative active site pocket [active] 1310114003103 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1310114003104 potential frameshift: common BLAST hit: gi|449063403|ref|YP_007430486.1| ATP-dependent helicase DING 1310114003105 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1310114003106 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1310114003107 potential frameshift: common BLAST hit: gi|471337256|ref|YP_007609969.1| probable hydrolase 1310114003108 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1310114003109 MPN+ (JAMM) motif; other site 1310114003110 Zinc-binding site [ion binding]; other site 1310114003111 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1310114003112 MoaE interaction surface [polypeptide binding]; other site 1310114003113 MoeB interaction surface [polypeptide binding]; other site 1310114003114 thiocarboxylated glycine; other site 1310114003115 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1310114003116 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1310114003117 dimer interface [polypeptide binding]; other site 1310114003118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114003119 catalytic residue [active] 1310114003120 Rhomboid family; Region: Rhomboid; pfam01694 1310114003121 glutamate racemase; Provisional; Region: PRK00865 1310114003122 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1310114003123 ribonuclease PH; Reviewed; Region: rph; PRK00173 1310114003124 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1310114003125 hexamer interface [polypeptide binding]; other site 1310114003126 active site 1310114003127 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1310114003128 active site 1310114003129 dimerization interface [polypeptide binding]; other site 1310114003130 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1310114003131 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1310114003132 acyl carrier protein; Validated; Region: PRK05883 1310114003133 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1310114003134 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114003135 acyl-activating enzyme (AAE) consensus motif; other site 1310114003136 AMP binding site [chemical binding]; other site 1310114003137 active site 1310114003138 CoA binding site [chemical binding]; other site 1310114003139 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114003140 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114003141 active site 1310114003142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1310114003143 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1310114003144 potential frameshift: common BLAST hit: gi|433626450|ref|YP_007260079.1| Iron import ATP-binding/permease protein IrtA (Iron-regulated 1310114003145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114003146 Q-loop/lid; other site 1310114003147 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310114003148 ABC transporter signature motif; other site 1310114003149 Walker B; other site 1310114003150 D-loop; other site 1310114003151 H-loop/switch region; other site 1310114003152 potential frameshift: common BLAST hit: gi|471337272|ref|YP_007609985.1| drugs-transport transmembrane ATP-bindingprotein ABC transporter 1310114003153 potential frameshift: common BLAST hit: gi|471337272|ref|YP_007609985.1| drugs-transport transmembrane ATP-bindingprotein ABC transporter 1310114003154 potential frameshift: common BLAST hit: gi|471337272|ref|YP_007609985.1| drugs-transport transmembrane ATP-bindingprotein ABC transporter 1310114003155 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1310114003156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114003157 NAD(P) binding site [chemical binding]; other site 1310114003158 active site 1310114003159 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1310114003160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114003161 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1310114003162 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1310114003163 GAF domain; Region: GAF; pfam01590 1310114003164 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1310114003165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1310114003166 metal binding site [ion binding]; metal-binding site 1310114003167 active site 1310114003168 I-site; other site 1310114003169 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1310114003170 hypothetical protein; Provisional; Region: PRK07877 1310114003171 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1310114003172 ATP binding site [chemical binding]; other site 1310114003173 substrate interface [chemical binding]; other site 1310114003174 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1310114003175 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310114003176 cyclase homology domain; Region: CHD; cd07302 1310114003177 nucleotidyl binding site; other site 1310114003178 dimer interface [polypeptide binding]; other site 1310114003179 metal binding site [ion binding]; metal-binding site 1310114003180 AAA ATPase domain; Region: AAA_16; pfam13191 1310114003181 Predicted ATPase [General function prediction only]; Region: COG3903 1310114003182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310114003183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310114003184 DNA binding residues [nucleotide binding] 1310114003185 dimerization interface [polypeptide binding]; other site 1310114003186 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310114003187 cyclase homology domain; Region: CHD; cd07302 1310114003188 potential frameshift: common BLAST hit: gi|471337282|ref|YP_007609995.1| oxidoreductase 1310114003189 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114003190 PPE family; Region: PPE; pfam00823 1310114003191 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114003192 PAS fold; Region: PAS_4; pfam08448 1310114003193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1310114003194 putative active site [active] 1310114003195 heme pocket [chemical binding]; other site 1310114003196 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1310114003197 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1310114003198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1310114003199 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310114003200 anti sigma factor interaction site; other site 1310114003201 regulatory phosphorylation site [posttranslational modification]; other site 1310114003202 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310114003203 anti sigma factor interaction site; other site 1310114003204 regulatory phosphorylation site [posttranslational modification]; other site 1310114003205 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1310114003206 synthetase active site [active] 1310114003207 NTP binding site [chemical binding]; other site 1310114003208 metal binding site [ion binding]; metal-binding site 1310114003209 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114003210 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114003211 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1310114003212 putative transposase OrfB; Reviewed; Region: PHA02517 1310114003213 HTH-like domain; Region: HTH_21; pfam13276 1310114003214 Integrase core domain; Region: rve; pfam00665 1310114003215 Integrase core domain; Region: rve_3; pfam13683 1310114003216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114003217 Transposase; Region: HTH_Tnp_1; cl17663 1310114003218 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1310114003219 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1310114003220 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1310114003221 putative di-iron ligands [ion binding]; other site 1310114003222 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1310114003223 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1310114003224 malonyl-CoA binding site [chemical binding]; other site 1310114003225 dimer interface [polypeptide binding]; other site 1310114003226 active site 1310114003227 product binding site; other site 1310114003228 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1310114003229 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1310114003230 YcaO-like family; Region: YcaO; pfam02624 1310114003231 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1310114003232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003233 S-adenosylmethionine binding site [chemical binding]; other site 1310114003234 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114003235 active site 1310114003236 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1310114003237 potential frameshift: common BLAST hit: gi|471337300|ref|YP_007610013.1| aspartate carbamoyltransferase catalyticsubunit 1310114003238 potential frameshift: common BLAST hit: gi|397673226|ref|YP_006514761.1| dihydroorotase 1310114003239 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1310114003240 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1310114003241 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1310114003242 conserved cys residue [active] 1310114003243 carbamoyl-phosphate synthase, small subunit; Region: CPSaseIIsmall; TIGR01368 1310114003244 potential frameshift: common BLAST hit: gi|385994408|ref|YP_005912706.1| carbamoyl phosphate synthase large subunit 1310114003245 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310114003246 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1310114003247 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1310114003248 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310114003249 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1310114003250 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310114003251 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1310114003252 IMP binding site; other site 1310114003253 dimer interface [polypeptide binding]; other site 1310114003254 interdomain contacts; other site 1310114003255 partial ornithine binding site; other site 1310114003256 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1310114003257 active site 1310114003258 dimer interface [polypeptide binding]; other site 1310114003259 PE family; Region: PE; pfam00934 1310114003260 potential frameshift: common BLAST hit: gi|471337307|ref|YP_007610020.1| PPE family protein 1310114003261 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1310114003262 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1310114003263 catalytic site [active] 1310114003264 G-X2-G-X-G-K; other site 1310114003265 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1310114003266 potential frameshift: common BLAST hit: gi|433634453|ref|YP_007268080.1| Putative DNA/pantothenate metabolism flavoprotein homolog Dfp 1310114003267 potential frameshift: common BLAST hit: gi|253799559|ref|YP_003032560.1| S-adenosylmethionine synthetase 1310114003268 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114003269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310114003270 potential frameshift: common BLAST hit: gi|471337314|ref|YP_007610027.1| cytochrome P450 132 1310114003271 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1310114003272 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310114003273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310114003274 PE family; Region: PE; pfam00934 1310114003275 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1310114003276 oligomeric interface; other site 1310114003277 putative active site [active] 1310114003278 homodimer interface [polypeptide binding]; other site 1310114003279 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114003280 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310114003281 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310114003282 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310114003283 potential frameshift: common BLAST hit: gi|471337320|ref|YP_007610033.1| lipase 1310114003284 Predicted membrane protein [Function unknown]; Region: COG3714 1310114003285 potential frameshift: common BLAST hit: gi|449063480|ref|YP_007430563.1| primosomal protein N priA (replication factor Y) 1310114003286 potential frameshift: common BLAST hit: gi|449063480|ref|YP_007430563.1| primosomal protein N priA (replication factor Y) 1310114003287 potential frameshift: common BLAST hit: gi|449063480|ref|YP_007430563.1| primosomal protein N priA (replication factor Y) 1310114003288 potential frameshift: common BLAST hit: gi|449063480|ref|YP_007430563.1| primosomal protein N priA (replication factor Y) 1310114003289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003290 S-adenosylmethionine binding site [chemical binding]; other site 1310114003291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310114003292 MarR family; Region: MarR; pfam01047 1310114003293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003294 S-adenosylmethionine binding site [chemical binding]; other site 1310114003295 potential frameshift: common BLAST hit: gi|471337326|ref|YP_007610039.1| methionyl-tRNA formyltransferase 1310114003296 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1310114003297 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1310114003298 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1310114003299 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1310114003300 substrate binding site [chemical binding]; other site 1310114003301 hexamer interface [polypeptide binding]; other site 1310114003302 metal binding site [ion binding]; metal-binding site 1310114003303 potential frameshift: common BLAST hit: gi|471337329|ref|YP_007610042.1| bifunctionaldiaminohydroxyphosphoribosylaminopyrimidinedea minase/5- 1310114003304 potential frameshift: common BLAST hit: gi|449063488|ref|YP_007430571.1| aminoglycosides/tetracycline-transport integral membrane protein 1310114003305 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1310114003306 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1310114003307 Lumazine binding domain; Region: Lum_binding; pfam00677 1310114003308 Lumazine binding domain; Region: Lum_binding; pfam00677 1310114003309 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1310114003310 catalytic residue [active] 1310114003311 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1310114003312 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1310114003313 potential frameshift: common BLAST hit: gi|471337335|ref|YP_007610048.1| bifunctional 3,4-dihydroxy-2-butanone4-phosphate synthase/GTP 1310114003314 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1310114003315 homopentamer interface [polypeptide binding]; other site 1310114003316 active site 1310114003317 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1310114003318 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310114003319 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1310114003320 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1310114003321 putative sugar binding sites [chemical binding]; other site 1310114003322 Q-X-W motif; other site 1310114003323 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1310114003324 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1310114003325 GIY-YIG motif/motif A; other site 1310114003326 active site 1310114003327 catalytic site [active] 1310114003328 putative DNA binding site [nucleotide binding]; other site 1310114003329 metal binding site [ion binding]; metal-binding site 1310114003330 UvrB/uvrC motif; Region: UVR; pfam02151 1310114003331 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1310114003332 Helix-hairpin-helix motif; Region: HHH; pfam00633 1310114003333 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1310114003334 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1310114003335 putative substrate binding pocket [chemical binding]; other site 1310114003336 dimer interface [polypeptide binding]; other site 1310114003337 phosphate binding site [ion binding]; other site 1310114003338 potential frameshift: common BLAST hit: gi|386004404|ref|YP_005922683.1| sporulation transcription regulator whiA 1310114003339 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114003340 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114003341 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310114003342 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310114003343 potential frameshift: common BLAST hit: gi|433626527|ref|YP_007260156.1| Putative long-chain-fatty-acid--CoA ligase FadD12 (fatty-acid-CoA 1310114003344 potential frameshift: common BLAST hit: gi|471337347|ref|YP_007610060.1| acyl-CoA synthetase 1310114003345 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114003346 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1310114003347 putative acyl-acceptor binding pocket; other site 1310114003348 PE family; Region: PE; pfam00934 1310114003349 PE-PPE domain; Region: PE-PPE; pfam08237 1310114003350 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1310114003351 potential frameshift: common BLAST hit: gi|471337352|ref|YP_007610065.1| dehydrogenase 1310114003352 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1310114003353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310114003354 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310114003355 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1310114003356 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1310114003357 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1310114003358 Phosphoglycerate kinase; Region: PGK; pfam00162 1310114003359 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1310114003360 substrate binding site [chemical binding]; other site 1310114003361 hinge regions; other site 1310114003362 ADP binding site [chemical binding]; other site 1310114003363 catalytic site [active] 1310114003364 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1310114003365 substrate binding site [chemical binding]; other site 1310114003366 dimer interface [polypeptide binding]; other site 1310114003367 catalytic triad [active] 1310114003368 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310114003369 Preprotein translocase SecG subunit; Region: SecG; cl09123 1310114003370 PE family; Region: PE; pfam00934 1310114003371 potential frameshift: common BLAST hit: gi|449063520|ref|YP_007430603.1| biotin sulfoxide reductase 1310114003372 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1310114003373 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1310114003374 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1310114003375 putative active site [active] 1310114003376 potential frameshift: common BLAST hit: gi|471337369|ref|YP_007610082.1| putative OXPP cycle protein 1310114003377 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1310114003378 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1310114003379 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1310114003380 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1310114003381 putative active site [active] 1310114003382 transaldolase; Provisional; Region: PRK03903 1310114003383 catalytic residue [active] 1310114003384 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1310114003385 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1310114003386 TPP-binding site [chemical binding]; other site 1310114003387 dimer interface [polypeptide binding]; other site 1310114003388 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1310114003389 PYR/PP interface [polypeptide binding]; other site 1310114003390 dimer interface [polypeptide binding]; other site 1310114003391 TPP binding site [chemical binding]; other site 1310114003392 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1310114003393 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310114003394 PE family; Region: PE; pfam00934 1310114003395 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310114003396 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310114003397 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1310114003398 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1310114003399 NADP binding site [chemical binding]; other site 1310114003400 dimer interface [polypeptide binding]; other site 1310114003401 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1310114003402 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1310114003403 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1310114003404 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1310114003405 potential frameshift: common BLAST hit: gi|386004448|ref|YP_005922727.1| unidentified antibiotic-transport ATP-binding protein ABC 1310114003406 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1310114003407 putative DNA binding site [nucleotide binding]; other site 1310114003408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1310114003409 putative Zn2+ binding site [ion binding]; other site 1310114003410 Predicted transcriptional regulator [Transcription]; Region: COG2345 1310114003411 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1310114003412 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1310114003413 protein-splicing catalytic site; other site 1310114003414 thioester formation/cholesterol transfer; other site 1310114003415 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1310114003416 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1310114003417 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1310114003418 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1310114003419 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1310114003420 Walker A/P-loop; other site 1310114003421 ATP binding site [chemical binding]; other site 1310114003422 Q-loop/lid; other site 1310114003423 ABC transporter signature motif; other site 1310114003424 Walker B; other site 1310114003425 D-loop; other site 1310114003426 H-loop/switch region; other site 1310114003427 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1310114003428 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1310114003429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114003430 catalytic residue [active] 1310114003431 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1310114003432 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1310114003433 trimerization site [polypeptide binding]; other site 1310114003434 active site 1310114003435 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1310114003436 potential frameshift: common BLAST hit: gi|471337393|ref|YP_007610106.1| acyl-CoA dehydrogenase 1310114003437 potential frameshift: common BLAST hit: gi|471337393|ref|YP_007610106.1| acyl-CoA dehydrogenase 1310114003438 PE family; Region: PE; pfam00934 1310114003439 potential frameshift: common BLAST hit: gi|449063550|ref|YP_007430633.1| cation transporter ATPase D ctpD 1310114003440 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1310114003441 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310114003442 catalytic residues [active] 1310114003443 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310114003444 catalytic residues [active] 1310114003445 enoyl-CoA hydratase; Provisional; Region: PRK05864 1310114003446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114003447 substrate binding site [chemical binding]; other site 1310114003448 oxyanion hole (OAH) forming residues; other site 1310114003449 trimer interface [polypeptide binding]; other site 1310114003450 potential frameshift: common BLAST hit: gi|433626574|ref|YP_007260203.1| Putative macrolide-transport ATP-binding protein ABC transporter 1310114003451 potential frameshift: common BLAST hit: gi|471337400|ref|YP_007610113.1| macrolide ABC transporter ATP-binding protein 1310114003452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114003453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114003454 potential frameshift: common BLAST hit: gi|449063557|ref|YP_007430640.1| aconitate hydratase 1310114003455 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310114003456 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310114003457 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310114003458 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310114003459 MoxR-like ATPases [General function prediction only]; Region: COG0714 1310114003460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114003461 Walker A motif; other site 1310114003462 ATP binding site [chemical binding]; other site 1310114003463 Walker B motif; other site 1310114003464 arginine finger; other site 1310114003465 potential frameshift: common BLAST hit: gi|433641632|ref|YP_007287391.1| Conserved membrane protein of unknown function 1310114003466 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1310114003467 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1310114003468 NAD(P) binding site [chemical binding]; other site 1310114003469 homotetramer interface [polypeptide binding]; other site 1310114003470 homodimer interface [polypeptide binding]; other site 1310114003471 active site 1310114003472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114003473 NAD(P) binding site [chemical binding]; other site 1310114003474 active site 1310114003475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114003476 potential frameshift: common BLAST hit: gi|471337413|ref|YP_007610126.1| ferrochelatase 1310114003477 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1310114003478 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1310114003479 Transposase domain (DUF772); Region: DUF772; pfam05598 1310114003480 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1310114003481 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310114003482 potential frameshift: common BLAST hit: gi|471337422|ref|YP_007610135.1| methylmalonyl-CoA mutase small subunit 1310114003483 potential frameshift: common BLAST hit: gi|433630601|ref|YP_007264229.1| Methylmalonyl-CoA mutase small subunit MutA (MCM) 1310114003484 potential frameshift: common BLAST hit: gi|449063576|ref|YP_007430659.1| methylmalonyl-CoA mutase small subunit mutA 1310114003485 potential frameshift: common BLAST hit: gi|471337423|ref|YP_007610136.1| methylmalonyl-CoA mutase 1310114003486 potential frameshift: common BLAST hit: gi|471337423|ref|YP_007610136.1| methylmalonyl-CoA mutase 1310114003487 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310114003488 potential frameshift: common BLAST hit: gi|471337426|ref|YP_007610139.1| arginine/ornithine transport system ATPase 1310114003489 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114003490 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114003491 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310114003492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003493 S-adenosylmethionine binding site [chemical binding]; other site 1310114003494 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1310114003495 NUDIX domain; Region: NUDIX; pfam00293 1310114003496 nudix motif; other site 1310114003497 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1310114003498 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1310114003499 Ligand binding site; other site 1310114003500 Putative Catalytic site; other site 1310114003501 DXD motif; other site 1310114003502 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1310114003503 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1310114003504 active site 1310114003505 potential frameshift: common BLAST hit: gi|433641656|ref|YP_007287415.1| Lipopolysaccharide biosynthesis protein RffA 1310114003506 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1310114003507 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1310114003508 putative trimer interface [polypeptide binding]; other site 1310114003509 putative CoA binding site [chemical binding]; other site 1310114003510 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1310114003511 S-adenosylmethionine binding site [chemical binding]; other site 1310114003512 WbqC-like protein family; Region: WbqC; pfam08889 1310114003513 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1310114003514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114003515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114003516 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310114003517 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1310114003518 potential frameshift: common BLAST hit: gi|433641664|ref|YP_007287423.1| Conserved membrane protein of unknown function 1310114003519 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1310114003520 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1310114003521 NADP-binding site; other site 1310114003522 homotetramer interface [polypeptide binding]; other site 1310114003523 substrate binding site [chemical binding]; other site 1310114003524 homodimer interface [polypeptide binding]; other site 1310114003525 active site 1310114003526 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1310114003527 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1310114003528 NADP binding site [chemical binding]; other site 1310114003529 active site 1310114003530 putative substrate binding site [chemical binding]; other site 1310114003531 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1310114003532 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1310114003533 metal-binding site 1310114003534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003535 S-adenosylmethionine binding site [chemical binding]; other site 1310114003536 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310114003537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310114003538 active site 1310114003539 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1310114003540 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310114003541 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1310114003542 active site 1310114003543 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1310114003544 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114003545 potential frameshift: common BLAST hit: gi|392432880|ref|YP_006473924.1| sugar transferase 1310114003546 acyl-CoA synthetase; Validated; Region: PRK05850 1310114003547 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114003548 acyl-activating enzyme (AAE) consensus motif; other site 1310114003549 active site 1310114003550 Transport protein; Region: actII; TIGR00833 1310114003551 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310114003552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003553 S-adenosylmethionine binding site [chemical binding]; other site 1310114003554 potential frameshift: common BLAST hit: gi|471337460|ref|YP_007610173.1| glycosyltransferase 1310114003555 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310114003556 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1310114003557 Probable Catalytic site; other site 1310114003558 metal-binding site 1310114003559 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1310114003560 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1310114003561 homodimer interface [polypeptide binding]; other site 1310114003562 active site 1310114003563 TDP-binding site; other site 1310114003564 acceptor substrate-binding pocket; other site 1310114003565 potential frameshift: common BLAST hit: gi|433626632|ref|YP_007260261.1| Putative polyketide synthase pKs5 1310114003566 potential frameshift: common BLAST hit: gi|397673380|ref|YP_006514915.1| phthioceranic/hydroxyphthioceranic acid synthase 1310114003567 potential frameshift: common BLAST hit: gi|397673380|ref|YP_006514915.1| phthioceranic/hydroxyphthioceranic acid synthase 1310114003568 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1310114003569 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310114003570 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114003571 active site 1310114003572 acyl-CoA synthetase; Validated; Region: PRK05850 1310114003573 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114003574 acyl-activating enzyme (AAE) consensus motif; other site 1310114003575 active site 1310114003576 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1310114003577 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114003578 NAD(P) binding site [chemical binding]; other site 1310114003579 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114003580 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310114003581 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1310114003582 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1310114003583 CoenzymeA binding site [chemical binding]; other site 1310114003584 subunit interaction site [polypeptide binding]; other site 1310114003585 PHB binding site; other site 1310114003586 Nitronate monooxygenase; Region: NMO; pfam03060 1310114003587 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1310114003588 FMN binding site [chemical binding]; other site 1310114003589 substrate binding site [chemical binding]; other site 1310114003590 putative catalytic residue [active] 1310114003591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114003592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114003593 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1310114003594 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1310114003595 HIGH motif; other site 1310114003596 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1310114003597 active site 1310114003598 KMSKS motif; other site 1310114003599 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1310114003600 tRNA binding surface [nucleotide binding]; other site 1310114003601 anticodon binding site; other site 1310114003602 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1310114003603 potential frameshift: common BLAST hit: gi|449063611|ref|YP_007430694.1| DNA-damage-inducible protein P, putative 1310114003604 Y-family of DNA polymerases; Region: PolY; cl12025 1310114003605 DNA binding site [nucleotide binding] 1310114003606 lipoprotein signal peptidase; Provisional; Region: PRK14764 1310114003607 lipoprotein signal peptidase; Provisional; Region: PRK14787 1310114003608 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1310114003609 active site 1310114003610 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1310114003611 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1310114003612 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1310114003613 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1310114003614 apolar tunnel; other site 1310114003615 heme binding site [chemical binding]; other site 1310114003616 dimerization interface [polypeptide binding]; other site 1310114003617 short chain dehydrogenase; Provisional; Region: PRK05866 1310114003618 classical (c) SDRs; Region: SDR_c; cd05233 1310114003619 NAD(P) binding site [chemical binding]; other site 1310114003620 active site 1310114003621 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310114003622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114003623 NAD(P) binding site [chemical binding]; other site 1310114003624 active site 1310114003625 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310114003626 hydrophobic ligand binding site; other site 1310114003627 potential frameshift: common BLAST hit: gi|449063622|ref|YP_007430705.1| DNA polymerase III subunit alpha 1310114003628 potential frameshift: common BLAST hit: gi|449063622|ref|YP_007430705.1| DNA polymerase III subunit alpha 1310114003629 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114003630 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114003631 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1310114003632 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1310114003633 acyl-activating enzyme (AAE) consensus motif; other site 1310114003634 putative AMP binding site [chemical binding]; other site 1310114003635 putative active site [active] 1310114003636 putative CoA binding site [chemical binding]; other site 1310114003637 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1310114003638 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1310114003639 putative acyl-acceptor binding pocket; other site 1310114003640 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1310114003641 L-aspartate oxidase; Provisional; Region: PRK06175 1310114003642 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1310114003643 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1310114003644 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1310114003645 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1310114003646 D-subunit interface [polypeptide binding]; other site 1310114003647 Iron-sulfur protein interface; other site 1310114003648 proximal quinone binding site [chemical binding]; other site 1310114003649 distal quinone binding site [chemical binding]; other site 1310114003650 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1310114003651 Iron-sulfur protein interface; other site 1310114003652 proximal heme binding site [chemical binding]; other site 1310114003653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114003654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114003655 MMPL family; Region: MMPL; pfam03176 1310114003656 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310114003657 potential frameshift: common BLAST hit: gi|433634621|ref|YP_007268248.1| Putative threonine dehydratase IlvA 1310114003658 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310114003659 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310114003660 putative active site [active] 1310114003661 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1310114003662 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1310114003663 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1310114003664 catalytic site [active] 1310114003665 active site 1310114003666 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1310114003667 potential frameshift: common BLAST hit: gi|471337499|ref|YP_007610212.1| maltooligosyltrehalose synthase 1310114003668 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1310114003669 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1310114003670 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1310114003671 active site 1310114003672 catalytic site [active] 1310114003673 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310114003674 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310114003675 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310114003676 potential frameshift: common BLAST hit: gi|449063642|ref|YP_007430725.1| adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 1310114003677 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114003678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114003679 catalytic residue [active] 1310114003680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310114003681 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1310114003682 Phage capsid family; Region: Phage_capsid; pfam05065 1310114003683 Phage head maturation protease [General function prediction only]; Region: COG3740 1310114003684 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 1310114003685 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1310114003686 D5 N terminal like; Region: D5_N; smart00885 1310114003687 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1310114003688 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1310114003689 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114003690 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114003691 active site 1310114003692 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1310114003693 biotin synthase; Validated; Region: PRK06256 1310114003694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114003695 FeS/SAM binding site; other site 1310114003696 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1310114003697 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1310114003698 Secretory lipase; Region: LIP; pfam03583 1310114003699 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1310114003700 nudix motif; other site 1310114003701 potential frameshift: common BLAST hit: gi|471337514|ref|YP_007610227.1| quinolinate synthetase 1310114003702 potential frameshift: common BLAST hit: gi|397673449|ref|YP_006514984.1| L-aspartate oxidase 1310114003703 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1310114003704 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1310114003705 dimerization interface [polypeptide binding]; other site 1310114003706 active site 1310114003707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003708 S-adenosylmethionine binding site [chemical binding]; other site 1310114003709 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1310114003710 potential frameshift: common BLAST hit: gi|449063657|ref|YP_007430740.1| histidinol dehydrogenase 1310114003711 potential frameshift: common BLAST hit: gi|449063657|ref|YP_007430740.1| histidinol dehydrogenase 1310114003712 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1310114003713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310114003714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114003715 homodimer interface [polypeptide binding]; other site 1310114003716 catalytic residue [active] 1310114003717 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1310114003718 4-fold oligomerization interface [polypeptide binding]; other site 1310114003719 putative active site pocket [active] 1310114003720 metal binding residues [ion binding]; metal-binding site 1310114003721 3-fold/trimer interface [polypeptide binding]; other site 1310114003722 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1310114003723 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1310114003724 putative active site [active] 1310114003725 oxyanion strand; other site 1310114003726 catalytic triad [active] 1310114003727 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1310114003728 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1310114003729 catalytic residues [active] 1310114003730 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1310114003731 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1310114003732 active site 1310114003733 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1310114003734 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1310114003735 substrate binding site [chemical binding]; other site 1310114003736 glutamase interaction surface [polypeptide binding]; other site 1310114003737 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1310114003738 potential frameshift: common BLAST hit: gi|471337527|ref|YP_007610240.1| ionic transporter integral membrane protein 1310114003739 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1310114003740 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1310114003741 catalytic triad [active] 1310114003742 anthranilate synthase component I; Provisional; Region: PRK13571 1310114003743 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1310114003744 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1310114003745 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1310114003746 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310114003747 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1310114003748 active site 1310114003749 product (indole) binding pocket [chemical binding]; other site 1310114003750 substrate (anthranilate) binding pocket [chemical binding]; other site 1310114003751 ribulose/triose binding site [chemical binding]; other site 1310114003752 phosphate binding site [ion binding]; other site 1310114003753 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1310114003754 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1310114003755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114003756 catalytic residue [active] 1310114003757 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1310114003758 substrate binding site [chemical binding]; other site 1310114003759 active site 1310114003760 catalytic residues [active] 1310114003761 heterodimer interface [polypeptide binding]; other site 1310114003762 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1310114003763 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1310114003764 TM2 domain; Region: TM2; pfam05154 1310114003765 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1310114003766 potential frameshift: common BLAST hit: gi|449063675|ref|YP_007430758.1| pyruvate kinase 1310114003767 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1310114003768 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1310114003769 active site 1310114003770 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1310114003771 catalytic triad [active] 1310114003772 dimer interface [polypeptide binding]; other site 1310114003773 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1310114003774 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1310114003775 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1310114003776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114003777 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1310114003778 Walker A/P-loop; other site 1310114003779 Walker A/P-loop; other site 1310114003780 ATP binding site [chemical binding]; other site 1310114003781 ATP binding site [chemical binding]; other site 1310114003782 Q-loop/lid; other site 1310114003783 potential frameshift: common BLAST hit: gi|471337541|ref|YP_007610254.1| vytochrome' transport transmembrane ATP-bindingprotein ABC 1310114003784 potential frameshift: common BLAST hit: gi|471337541|ref|YP_007610254.1| vytochrome' transport transmembrane ATP-bindingprotein ABC 1310114003785 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1310114003786 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1310114003787 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1310114003788 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1310114003789 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1310114003790 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1310114003791 cyclase homology domain; Region: CHD; cd07302 1310114003792 nucleotidyl binding site; other site 1310114003793 metal binding site [ion binding]; metal-binding site 1310114003794 dimer interface [polypeptide binding]; other site 1310114003795 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1310114003796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114003797 active site 1310114003798 phosphorylation site [posttranslational modification] 1310114003799 intermolecular recognition site; other site 1310114003800 dimerization interface [polypeptide binding]; other site 1310114003801 ANTAR domain; Region: ANTAR; pfam03861 1310114003802 potential frameshift: common BLAST hit: gi|471337547|ref|YP_007610260.1| lipid-transfer protein 1310114003803 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1310114003804 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1310114003805 DUF35 OB-fold domain; Region: DUF35; pfam01796 1310114003806 potential frameshift: common BLAST hit: gi|339631685|ref|YP_004723327.1| DNA polymerase I 1310114003807 potential frameshift: common BLAST hit: gi|339631685|ref|YP_004723327.1| DNA polymerase I 1310114003808 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1310114003809 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1310114003810 RNA binding site [nucleotide binding]; other site 1310114003811 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1310114003812 RNA binding site [nucleotide binding]; other site 1310114003813 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1310114003814 RNA binding site [nucleotide binding]; other site 1310114003815 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1310114003816 RNA binding site [nucleotide binding]; other site 1310114003817 potential frameshift: common BLAST hit: gi|471337551|ref|YP_007610264.1| fused dephospho-CoA kinase/unknowndomain-containing protein 1310114003818 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1310114003819 excinuclease ABC subunit B; Provisional; Region: PRK05298 1310114003820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310114003821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310114003822 nucleotide binding region [chemical binding]; other site 1310114003823 ATP-binding site [chemical binding]; other site 1310114003824 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1310114003825 UvrB/uvrC motif; Region: UVR; pfam02151 1310114003826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114003827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310114003828 putative substrate translocation pore; other site 1310114003829 Predicted membrane protein [Function unknown]; Region: COG5305 1310114003830 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114003831 Ligand Binding Site [chemical binding]; other site 1310114003832 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310114003833 potential frameshift: common BLAST hit: gi|15841093|ref|NP_336130.1| excinuclease ABC subunit A 1310114003834 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1310114003835 Predicted esterase [General function prediction only]; Region: COG0627 1310114003836 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1310114003837 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1310114003838 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1310114003839 dimer interface [polypeptide binding]; other site 1310114003840 putative anticodon binding site; other site 1310114003841 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310114003842 motif 1; other site 1310114003843 dimer interface [polypeptide binding]; other site 1310114003844 active site 1310114003845 motif 2; other site 1310114003846 motif 3; other site 1310114003847 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1310114003848 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1310114003849 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1310114003850 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1310114003851 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1310114003852 23S rRNA binding site [nucleotide binding]; other site 1310114003853 L21 binding site [polypeptide binding]; other site 1310114003854 L13 binding site [polypeptide binding]; other site 1310114003855 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310114003856 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310114003857 PE family; Region: PE; pfam00934 1310114003858 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310114003859 cyclase homology domain; Region: CHD; cd07302 1310114003860 nucleotidyl binding site; other site 1310114003861 metal binding site [ion binding]; metal-binding site 1310114003862 dimer interface [polypeptide binding]; other site 1310114003863 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1310114003864 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1310114003865 dimer interface [polypeptide binding]; other site 1310114003866 motif 1; other site 1310114003867 active site 1310114003868 motif 2; other site 1310114003869 motif 3; other site 1310114003870 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1310114003871 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1310114003872 putative tRNA-binding site [nucleotide binding]; other site 1310114003873 B3/4 domain; Region: B3_4; pfam03483 1310114003874 tRNA synthetase B5 domain; Region: B5; smart00874 1310114003875 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310114003876 active site 1310114003877 motif 3; other site 1310114003878 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1310114003879 PE family; Region: PE; pfam00934 1310114003880 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1310114003881 potential frameshift: common BLAST hit: gi|471337578|ref|YP_007610291.1| bifunctional ornithineacetyltransferase/N-acetylglutamate synthase 1310114003882 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1310114003883 nucleotide binding site [chemical binding]; other site 1310114003884 potential frameshift: common BLAST hit: gi|471337580|ref|YP_007610293.1| acetylornithine aminotransferase 1310114003885 potential frameshift: common BLAST hit: gi|471337580|ref|YP_007610293.1| acetylornithine aminotransferase 1310114003886 potential frameshift: common BLAST hit: gi|471337581|ref|YP_007610294.1| ornithine carbamoyltransferase 1310114003887 potential frameshift: common BLAST hit: gi|392432760|ref|YP_006473804.1| arginine repressor argR 1310114003888 potential frameshift: common BLAST hit: gi|471337583|ref|YP_007610296.1| argininosuccinate synthase 1310114003889 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1310114003890 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1310114003891 tetramer interface [polypeptide binding]; other site 1310114003892 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1310114003893 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1310114003894 malonyl-CoA binding site [chemical binding]; other site 1310114003895 dimer interface [polypeptide binding]; other site 1310114003896 active site 1310114003897 product binding site; other site 1310114003898 potential frameshift: common BLAST hit: gi|471337586|ref|YP_007610299.1| polyketide synthase 1310114003899 potential frameshift: common BLAST hit: gi|471337586|ref|YP_007610299.1| polyketide synthase 1310114003900 potential frameshift: common BLAST hit: gi|471337586|ref|YP_007610299.1| polyketide synthase 1310114003901 potential frameshift: common BLAST hit: gi|471337587|ref|YP_007610300.1| polyketide synthase 1310114003902 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114003903 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1310114003904 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310114003905 putative NADP binding site [chemical binding]; other site 1310114003906 active site 1310114003907 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310114003908 potential frameshift: common BLAST hit: gi|471337589|ref|YP_007610302.1| polyketide synthase 1310114003909 potential frameshift: common BLAST hit: gi|433630759|ref|YP_007264387.1| Putative chalcone synthase Pks11 1310114003910 Cytochrome P450; Region: p450; cl12078 1310114003911 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114003912 potential frameshift: common BLAST hit: gi|392432750|ref|YP_006473794.1| macrolide-transport ATP-binding protein ABC transporter 1310114003913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1310114003914 potential frameshift: common BLAST hit: gi|471337595|ref|YP_007610308.1| integral membrane transport protein 1310114003915 potential frameshift: common BLAST hit: gi|471337595|ref|YP_007610308.1| integral membrane transport protein 1310114003916 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310114003917 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1310114003918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114003919 dimerization interface [polypeptide binding]; other site 1310114003920 putative DNA binding site [nucleotide binding]; other site 1310114003921 putative Zn2+ binding site [ion binding]; other site 1310114003922 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1310114003923 active site residue [active] 1310114003924 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310114003925 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310114003926 ligand binding site [chemical binding]; other site 1310114003927 flexible hinge region; other site 1310114003928 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1310114003929 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1310114003930 putative catalytic residues [active] 1310114003931 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1310114003932 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310114003933 catalytic residues [active] 1310114003934 potential frameshift: common BLAST hit: gi|471337602|ref|YP_007610315.1| integral membrane protein 1310114003935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114003936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114003937 active site 1310114003938 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1310114003939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114003940 FeS/SAM binding site; other site 1310114003941 DivIVA protein; Region: DivIVA; pfam05103 1310114003942 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1310114003943 acyl-CoA synthetase; Validated; Region: PRK07868 1310114003944 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114003945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114003946 acyl-activating enzyme (AAE) consensus motif; other site 1310114003947 AMP binding site [chemical binding]; other site 1310114003948 active site 1310114003949 CoA binding site [chemical binding]; other site 1310114003950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114003951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114003952 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1310114003953 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1310114003954 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310114003955 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1310114003956 Walker A/P-loop; other site 1310114003957 ATP binding site [chemical binding]; other site 1310114003958 Q-loop/lid; other site 1310114003959 ABC transporter signature motif; other site 1310114003960 Walker B; other site 1310114003961 D-loop; other site 1310114003962 H-loop/switch region; other site 1310114003963 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1310114003964 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1310114003965 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1310114003966 active site 1310114003967 HIGH motif; other site 1310114003968 dimer interface [polypeptide binding]; other site 1310114003969 KMSKS motif; other site 1310114003970 S4 RNA-binding domain; Region: S4; smart00363 1310114003971 RNA binding surface [nucleotide binding]; other site 1310114003972 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114003973 potential frameshift: common BLAST hit: gi|471337617|ref|YP_007610330.1| phosphatase 1310114003974 potential frameshift: common BLAST hit: gi|471337617|ref|YP_007610330.1| phosphatase 1310114003975 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1310114003976 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310114003977 RNA binding surface [nucleotide binding]; other site 1310114003978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114003979 S-adenosylmethionine binding site [chemical binding]; other site 1310114003980 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1310114003981 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1310114003982 potential frameshift: common BLAST hit: gi|471337621|ref|YP_007610334.1| DNA repair protein 1310114003983 potential frameshift: common BLAST hit: gi|339631750|ref|YP_004723392.1| recombination protein N 1310114003984 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1310114003985 Thiamine pyrophosphokinase; Region: TPK; cl08415 1310114003986 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1310114003987 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1310114003988 CTP synthetase; Validated; Region: pyrG; PRK05380 1310114003989 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1310114003990 Catalytic site [active] 1310114003991 active site 1310114003992 UTP binding site [chemical binding]; other site 1310114003993 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1310114003994 active site 1310114003995 putative oxyanion hole; other site 1310114003996 catalytic triad [active] 1310114003997 potential frameshift: common BLAST hit: gi|433641837|ref|YP_007287596.1| Nudix hydrolase 1310114003998 potential frameshift: common BLAST hit: gi|471337626|ref|YP_007610339.1| site-specific tyrosine recombinase 1310114003999 potential frameshift: common BLAST hit: gi|449063764|ref|YP_007430847.1| catechol-O-methyltransferase 1310114004000 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1310114004001 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004002 PPE family; Region: PPE; pfam00823 1310114004003 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114004004 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004005 PPE family; Region: PPE; pfam00823 1310114004006 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1310114004007 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310114004008 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1310114004009 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1310114004010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310114004011 P-loop; other site 1310114004012 Magnesium ion binding site [ion binding]; other site 1310114004013 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310114004014 Magnesium ion binding site [ion binding]; other site 1310114004015 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1310114004016 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1310114004017 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1310114004018 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310114004019 RNA binding surface [nucleotide binding]; other site 1310114004020 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1310114004021 active site 1310114004022 potential frameshift: common BLAST hit: gi|471337639|ref|YP_007610352.1| cytidylate kinase 1310114004023 potential frameshift: common BLAST hit: gi|449063775|ref|YP_007430858.1| GTP-binding protein engA 1310114004024 potential frameshift: common BLAST hit: gi|449063775|ref|YP_007430858.1| GTP-binding protein engA 1310114004025 potential frameshift: common BLAST hit: gi|449063776|ref|YP_007430859.1| oxidoreductase 1310114004026 potential frameshift: common BLAST hit: gi|471337642|ref|YP_007610355.1| 3-hydroxybutyryl-CoA dehydrogenase 1310114004027 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1310114004028 potential frameshift: common BLAST hit: gi|471337646|ref|YP_007610359.1| transcriptional regulator 1310114004029 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1310114004030 homotetrameric interface [polypeptide binding]; other site 1310114004031 putative active site [active] 1310114004032 metal binding site [ion binding]; metal-binding site 1310114004033 biotin carboxylase-like protein; Validated; Region: PRK06524 1310114004034 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1310114004035 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114004036 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114004037 Predicted transcriptional regulators [Transcription]; Region: COG1733 1310114004038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114004039 dimerization interface [polypeptide binding]; other site 1310114004040 putative DNA binding site [nucleotide binding]; other site 1310114004041 putative Zn2+ binding site [ion binding]; other site 1310114004042 Predicted transcriptional regulators [Transcription]; Region: COG1733 1310114004043 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310114004044 FAD binding domain; Region: FAD_binding_4; pfam01565 1310114004045 Berberine and berberine like; Region: BBE; pfam08031 1310114004046 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114004047 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114004048 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114004049 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114004050 potential frameshift: common BLAST hit: gi|471337662|ref|YP_007610375.1| succinic semialdehyde dehydrogenase 1310114004051 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1310114004052 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310114004053 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1310114004054 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1310114004055 gating phenylalanine in ion channel; other site 1310114004056 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1310114004057 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114004058 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1310114004059 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1310114004060 potential frameshift: common BLAST hit: gi|449063801|ref|YP_007430884.1| nitrate/nitrite transporter narK2 1310114004061 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1310114004062 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1310114004063 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1310114004064 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310114004065 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1310114004066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1310114004067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1310114004068 putative active site [active] 1310114004069 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1310114004070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310114004071 active site 1310114004072 ATP binding site [chemical binding]; other site 1310114004073 substrate binding site [chemical binding]; other site 1310114004074 activation loop (A-loop); other site 1310114004075 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1310114004076 Thioredoxin; Region: Thioredoxin_4; cl17273 1310114004077 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1310114004078 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1310114004079 active site 1310114004080 metal binding site [ion binding]; metal-binding site 1310114004081 nudix motif; other site 1310114004082 potential frameshift: common BLAST hit: gi|433641881|ref|YP_007287640.1| Anchored-membrane serine/threonine-protein kinase PknF (protein 1310114004083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310114004084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310114004085 phosphopeptide binding site; other site 1310114004086 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310114004087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310114004088 phosphopeptide binding site; other site 1310114004089 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1310114004090 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1310114004091 Walker A/P-loop; other site 1310114004092 ATP binding site [chemical binding]; other site 1310114004093 Q-loop/lid; other site 1310114004094 ABC transporter signature motif; other site 1310114004095 Walker B; other site 1310114004096 D-loop; other site 1310114004097 H-loop/switch region; other site 1310114004098 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1310114004099 acyl-CoA synthetase; Provisional; Region: PRK13388 1310114004100 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114004101 acyl-activating enzyme (AAE) consensus motif; other site 1310114004102 AMP binding site [chemical binding]; other site 1310114004103 active site 1310114004104 CoA binding site [chemical binding]; other site 1310114004105 hypothetical protein; Provisional; Region: PRK06185 1310114004106 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310114004107 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310114004108 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310114004109 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004110 PPE family; Region: PPE; pfam00823 1310114004111 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114004112 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114004113 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1310114004114 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1310114004115 putative transposase OrfB; Reviewed; Region: PHA02517 1310114004116 HTH-like domain; Region: HTH_21; pfam13276 1310114004117 Integrase core domain; Region: rve; pfam00665 1310114004118 Integrase core domain; Region: rve_3; pfam13683 1310114004119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114004120 Transposase; Region: HTH_Tnp_1; cl17663 1310114004121 Cutinase; Region: Cutinase; pfam01083 1310114004122 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114004123 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114004124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114004125 Transposase; Region: HTH_Tnp_1; cl17663 1310114004126 putative transposase OrfB; Reviewed; Region: PHA02517 1310114004127 HTH-like domain; Region: HTH_21; pfam13276 1310114004128 Integrase core domain; Region: rve; pfam00665 1310114004129 Integrase core domain; Region: rve_3; pfam13683 1310114004130 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114004131 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114004132 active site 1310114004133 Integrase core domain; Region: rve; pfam00665 1310114004134 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1310114004135 putative homotetramer interface [polypeptide binding]; other site 1310114004136 putative homodimer interface [polypeptide binding]; other site 1310114004137 putative allosteric switch controlling residues; other site 1310114004138 putative metal binding site [ion binding]; other site 1310114004139 putative homodimer-homodimer interface [polypeptide binding]; other site 1310114004140 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1310114004141 PE family; Region: PE; pfam00934 1310114004142 FAD binding domain; Region: FAD_binding_4; pfam01565 1310114004143 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1310114004144 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1310114004145 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1310114004146 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310114004147 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310114004148 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310114004149 FAD binding domain; Region: FAD_binding_4; pfam01565 1310114004150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114004151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114004152 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114004153 Cytochrome P450; Region: p450; cl12078 1310114004154 potential frameshift: common BLAST hit: gi|471337725|ref|YP_007610438.1| integral membrane protein 1310114004155 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1310114004156 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1310114004157 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1310114004158 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1310114004159 potential frameshift: common BLAST hit: gi|448816588|ref|YP_007410461.1| ESX conserved component EccC5 ESX-5 type VII secretion system protein 1310114004160 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114004161 Cytochrome P450; Region: p450; cl12078 1310114004162 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1310114004163 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004164 PPE family; Region: PPE; pfam00823 1310114004165 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114004166 PE family; Region: PE; pfam00934 1310114004167 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004168 PPE family; Region: PPE; pfam00823 1310114004169 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114004170 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004171 PPE family; Region: PPE; pfam00823 1310114004172 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114004173 PE family; Region: PE; pfam00934 1310114004174 potential frameshift: common BLAST hit: gi|433630299|ref|YP_007263927.1| Putative ESAT-6-like protein EsxJ (ESAT-6-like protein 2) 1310114004175 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310114004176 EspG family; Region: ESX-1_EspG; pfam14011 1310114004177 potential frameshift: common BLAST hit: gi|433641930|ref|YP_007287689.1| ESX conserved component EccD5 1310114004178 potential frameshift: common BLAST hit: gi|471337743|ref|YP_007610456.1| proline rich membrane-anchored mycosin 1310114004179 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1310114004180 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310114004181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114004182 Walker A motif; other site 1310114004183 ATP binding site [chemical binding]; other site 1310114004184 Walker B motif; other site 1310114004185 arginine finger; other site 1310114004186 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004187 PPE family; Region: PPE; pfam00823 1310114004188 PE-PPE domain; Region: PE-PPE; pfam08237 1310114004189 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004190 PPE family; Region: PPE; pfam00823 1310114004191 potential frameshift: common BLAST hit: gi|471337749|ref|YP_007610462.1| PPE family protein 1310114004192 PE family; Region: PE; pfam00934 1310114004193 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114004194 PE family; Region: PE; pfam00934 1310114004195 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004196 PPE family; Region: PPE; pfam00823 1310114004197 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004198 PPE family; Region: PPE; pfam00823 1310114004199 potential frameshift: common BLAST hit: gi|386004767|ref|YP_005923046.1| PPE family protein 1310114004200 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114004201 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1310114004202 MgtC family; Region: MgtC; pfam02308 1310114004203 potential frameshift: common BLAST hit: gi|397673677|ref|YP_006515212.1| NADH dehydrogenase-like protein 1310114004204 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1310114004205 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1310114004206 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1310114004207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114004208 hypothetical protein; Validated; Region: PRK07121 1310114004209 PE family; Region: PE; pfam00934 1310114004210 potential frameshift: common BLAST hit: gi|397673684|ref|YP_006515219.1| ATP-binding protein 1310114004211 potential frameshift: common BLAST hit: gi|433641952|ref|YP_007287711.1| Putative acetolactate synthase IlvG (acetohydroxy-acid 1310114004212 potential frameshift: common BLAST hit: gi|383307643|ref|YP_005360454.1| preprotein translocase subunit SecA 1310114004213 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1310114004214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1310114004215 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1310114004216 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1310114004217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1310114004218 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1310114004219 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1310114004220 lipoyl attachment site [posttranslational modification]; other site 1310114004221 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310114004222 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310114004223 phosphopeptide binding site; other site 1310114004224 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1310114004225 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310114004226 DNA binding residues [nucleotide binding] 1310114004227 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1310114004228 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1310114004229 DNA binding residues [nucleotide binding] 1310114004230 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310114004231 putative dimer interface [polypeptide binding]; other site 1310114004232 potential frameshift: common BLAST hit: gi|471337778|ref|YP_007610491.1| glycine dehydrogenase 1310114004233 haloalkane dehalogenase; Provisional; Region: PRK03204 1310114004234 potential frameshift: common BLAST hit: gi|449063895|ref|YP_007430978.1| hydrolase 1310114004235 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1310114004236 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1310114004237 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310114004238 metal ion-dependent adhesion site (MIDAS); other site 1310114004239 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1310114004240 active site 1310114004241 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310114004242 putative active site [active] 1310114004243 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310114004244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310114004245 FOG: CBS domain [General function prediction only]; Region: COG0517 1310114004246 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310114004247 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310114004248 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310114004249 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1310114004250 active site 1310114004251 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310114004252 FOG: CBS domain [General function prediction only]; Region: COG0517 1310114004253 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1310114004254 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310114004255 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1310114004256 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1310114004257 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1310114004258 Predicted transcriptional regulator [Transcription]; Region: COG3682 1310114004259 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1310114004260 CoenzymeA binding site [chemical binding]; other site 1310114004261 subunit interaction site [polypeptide binding]; other site 1310114004262 PHB binding site; other site 1310114004263 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1310114004264 beta-gamma subunit interface [polypeptide binding]; other site 1310114004265 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1310114004266 gamma-beta subunit interface [polypeptide binding]; other site 1310114004267 alpha-beta subunit interface [polypeptide binding]; other site 1310114004268 potential frameshift: common BLAST hit: gi|471337796|ref|YP_007610509.1| urease subunit alpha 1310114004269 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1310114004270 UreF; Region: UreF; pfam01730 1310114004271 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310114004272 potential frameshift: common BLAST hit: gi|392432567|ref|YP_006473611.1| urease accessory protein UreD 1310114004273 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1310114004274 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1310114004275 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1310114004276 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114004277 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310114004278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114004279 short chain dehydrogenase; Provisional; Region: PRK07890 1310114004280 NAD(P) binding site [chemical binding]; other site 1310114004281 active site 1310114004282 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1310114004283 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1310114004284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114004285 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1310114004286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114004287 Walker A/P-loop; other site 1310114004288 ATP binding site [chemical binding]; other site 1310114004289 Q-loop/lid; other site 1310114004290 ABC transporter signature motif; other site 1310114004291 Walker B; other site 1310114004292 D-loop; other site 1310114004293 H-loop/switch region; other site 1310114004294 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1310114004295 Predicted membrane protein [Function unknown]; Region: COG2261 1310114004296 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1310114004297 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1310114004298 putative NAD(P) binding site [chemical binding]; other site 1310114004299 putative substrate binding site [chemical binding]; other site 1310114004300 catalytic Zn binding site [ion binding]; other site 1310114004301 structural Zn binding site [ion binding]; other site 1310114004302 CAAX protease self-immunity; Region: Abi; pfam02517 1310114004303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1310114004304 MOSC domain; Region: MOSC; pfam03473 1310114004305 short chain dehydrogenase; Provisional; Region: PRK07825 1310114004306 classical (c) SDRs; Region: SDR_c; cd05233 1310114004307 NAD(P) binding site [chemical binding]; other site 1310114004308 active site 1310114004309 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310114004310 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310114004311 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310114004312 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310114004313 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1310114004314 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1310114004315 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310114004316 active site 1310114004317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310114004318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114004319 hypothetical protein; Provisional; Region: PRK12320 1310114004320 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1310114004321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310114004322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114004323 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310114004324 potential frameshift: common BLAST hit: gi|385994854|ref|YP_005913152.1| putative L-lactate dehydrogenase (cytochrome) lldD2 1310114004325 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1310114004326 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1310114004327 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1310114004328 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1310114004329 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1310114004330 heme binding site [chemical binding]; other site 1310114004331 ferroxidase pore; other site 1310114004332 ferroxidase diiron center [ion binding]; other site 1310114004333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114004334 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310114004335 putative substrate translocation pore; other site 1310114004336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114004337 putative substrate translocation pore; other site 1310114004338 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 1310114004339 23S rRNA interface [nucleotide binding]; other site 1310114004340 L3 interface [polypeptide binding]; other site 1310114004341 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310114004342 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1310114004343 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310114004344 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1310114004345 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114004346 Cytochrome P450; Region: p450; cl12078 1310114004347 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1310114004348 short chain dehydrogenase; Provisional; Region: PRK08267 1310114004349 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1310114004350 putative NAD(P) binding site [chemical binding]; other site 1310114004351 active site 1310114004352 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310114004353 hydrophobic ligand binding site; other site 1310114004354 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310114004355 chorismate mutase; Provisional; Region: PRK09269 1310114004356 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1310114004357 Putative esterase; Region: Esterase; pfam00756 1310114004358 potential frameshift: common BLAST hit: gi|433634937|ref|YP_007268564.1| Putative S-adenosyl-L-methionine-dependent methyltransferase 1310114004359 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1310114004360 Nitronate monooxygenase; Region: NMO; pfam03060 1310114004361 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1310114004362 FMN binding site [chemical binding]; other site 1310114004363 substrate binding site [chemical binding]; other site 1310114004364 putative catalytic residue [active] 1310114004365 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114004366 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1310114004367 NAD(P) binding site [chemical binding]; other site 1310114004368 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114004369 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114004370 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1310114004371 putative active site [active] 1310114004372 dimerization interface [polypeptide binding]; other site 1310114004373 putative tRNAtyr binding site [nucleotide binding]; other site 1310114004374 Domain of unknown function DUF77; Region: DUF77; pfam01910 1310114004375 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1310114004376 ADP-ribose binding site [chemical binding]; other site 1310114004377 potential frameshift: common BLAST hit: gi|433642035|ref|YP_007287794.1| Putative lignin peroxidase LipJ 1310114004378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114004379 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1310114004380 potential frameshift: common BLAST hit: gi|449063968|ref|YP_007431051.1| competence damage-inducible protein A 1310114004381 putative sialic acid transporter; Region: 2A0112; TIGR00891 1310114004382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114004383 putative substrate translocation pore; other site 1310114004384 Predicted membrane protein [Function unknown]; Region: COG1950 1310114004385 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310114004386 anti sigma factor interaction site; other site 1310114004387 regulatory phosphorylation site [posttranslational modification]; other site 1310114004388 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1310114004389 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1310114004390 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1310114004391 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1310114004392 dimer interface [polypeptide binding]; other site 1310114004393 active site 1310114004394 heme binding site [chemical binding]; other site 1310114004395 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1310114004396 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1310114004397 metal binding site 2 [ion binding]; metal-binding site 1310114004398 putative DNA binding helix; other site 1310114004399 metal binding site 1 [ion binding]; metal-binding site 1310114004400 dimer interface [polypeptide binding]; other site 1310114004401 structural Zn2+ binding site [ion binding]; other site 1310114004402 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1310114004403 substrate binding site [chemical binding]; other site 1310114004404 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1310114004405 substrate binding site [chemical binding]; other site 1310114004406 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114004407 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1310114004408 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310114004409 potential frameshift: common BLAST hit: gi|471337865|ref|YP_007610578.1| isocitrate lyase 1310114004410 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 1310114004411 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114004412 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004413 PPE family; Region: PPE; pfam00823 1310114004414 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114004415 potential frameshift: common BLAST hit: gi|385994899|ref|YP_005913197.1| PPE family protein 1310114004416 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1310114004417 putative hydrophobic ligand binding site [chemical binding]; other site 1310114004418 protein interface [polypeptide binding]; other site 1310114004419 gate; other site 1310114004420 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114004421 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1310114004422 putative acyl-acceptor binding pocket; other site 1310114004423 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1310114004424 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114004425 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114004426 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114004427 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114004428 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1310114004429 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114004430 acyl-activating enzyme (AAE) consensus motif; other site 1310114004431 active site 1310114004432 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1310114004433 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1310114004434 short chain dehydrogenase; Provisional; Region: PRK05867 1310114004435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114004436 NAD(P) binding site [chemical binding]; other site 1310114004437 active site 1310114004438 TIGR03085 family protein; Region: TIGR03085 1310114004439 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1310114004440 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1310114004441 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1310114004442 conserved cys residue [active] 1310114004443 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310114004444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310114004445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310114004446 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1310114004447 dimer interface [polypeptide binding]; other site 1310114004448 catalytic triad [active] 1310114004449 peroxidatic and resolving cysteines [active] 1310114004450 potential frameshift: common BLAST hit: gi|471337887|ref|YP_007610600.1| acyl-CoA dehydrogenase 1310114004451 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114004452 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1310114004453 FAD binding site [chemical binding]; other site 1310114004454 substrate binding site [chemical binding]; other site 1310114004455 catalytic base [active] 1310114004456 enoyl-CoA hydratase; Provisional; Region: PRK08290 1310114004457 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114004458 substrate binding site [chemical binding]; other site 1310114004459 oxyanion hole (OAH) forming residues; other site 1310114004460 trimer interface [polypeptide binding]; other site 1310114004461 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114004462 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1310114004463 potential frameshift: common BLAST hit: gi|471337891|ref|YP_007610604.1| oxygenase 1310114004464 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310114004465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310114004466 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1310114004467 potential frameshift: common BLAST hit: gi|471337894|ref|YP_007610607.1| riboflavin biosynthesis protein 1310114004468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114004469 NAD(P) binding site [chemical binding]; other site 1310114004470 active site 1310114004471 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310114004472 SEC-C motif; Region: SEC-C; pfam02810 1310114004473 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114004474 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114004475 active site 1310114004476 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1310114004477 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1310114004478 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1310114004479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310114004480 non-specific DNA binding site [nucleotide binding]; other site 1310114004481 salt bridge; other site 1310114004482 sequence-specific DNA binding site [nucleotide binding]; other site 1310114004483 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1310114004484 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1310114004485 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1310114004486 putative active site [active] 1310114004487 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310114004488 potential frameshift: common BLAST hit: gi|449064031|ref|YP_007431114.1| tetR-family transcriptional repressor mce3R 1310114004489 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310114004490 Permease; Region: Permease; pfam02405 1310114004491 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310114004492 Permease; Region: Permease; pfam02405 1310114004493 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114004494 mce related protein; Region: MCE; pfam02470 1310114004495 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310114004496 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114004497 mce related protein; Region: MCE; pfam02470 1310114004498 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114004499 mce related protein; Region: MCE; pfam02470 1310114004500 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114004501 mce related protein; Region: MCE; pfam02470 1310114004502 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114004503 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114004504 mce related protein; Region: MCE; pfam02470 1310114004505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114004506 mce related protein; Region: MCE; pfam02470 1310114004507 potential frameshift: common BLAST hit: gi|471337929|ref|YP_007610642.1| MCE associated membrane protein 1310114004508 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114004509 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1310114004510 YacP-like NYN domain; Region: NYN_YacP; cl01491 1310114004511 Peptidase family M48; Region: Peptidase_M48; pfam01435 1310114004512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114004513 S-adenosylmethionine binding site [chemical binding]; other site 1310114004514 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1310114004515 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1310114004516 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1310114004517 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1310114004518 dimer interface [polypeptide binding]; other site 1310114004519 putative radical transfer pathway; other site 1310114004520 diiron center [ion binding]; other site 1310114004521 tyrosyl radical; other site 1310114004522 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1310114004523 putative active site [active] 1310114004524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1310114004525 PE family; Region: PE; pfam00934 1310114004526 Cutinase; Region: Cutinase; pfam01083 1310114004527 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1310114004528 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1310114004529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310114004530 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310114004531 dimerization interface [polypeptide binding]; other site 1310114004532 Lysine efflux permease [General function prediction only]; Region: COG1279 1310114004533 Cellulose binding domain; Region: CBM_2; pfam00553 1310114004534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114004535 S-adenosylmethionine binding site [chemical binding]; other site 1310114004536 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1310114004537 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1310114004538 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1310114004539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114004540 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310114004541 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114004542 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1310114004543 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1310114004544 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310114004545 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1310114004546 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114004547 dimerization interface [polypeptide binding]; other site 1310114004548 putative DNA binding site [nucleotide binding]; other site 1310114004549 putative Zn2+ binding site [ion binding]; other site 1310114004550 Hemerythrin-like domain; Region: Hr-like; cd12108 1310114004551 Fe binding site [ion binding]; other site 1310114004552 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114004553 Ligand Binding Site [chemical binding]; other site 1310114004554 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114004555 Ligand Binding Site [chemical binding]; other site 1310114004556 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310114004557 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1310114004558 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310114004559 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310114004560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310114004561 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1310114004562 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310114004563 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310114004564 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310114004565 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1310114004566 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1310114004567 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1310114004568 tetramer interface [polypeptide binding]; other site 1310114004569 active site 1310114004570 Mg2+/Mn2+ binding site [ion binding]; other site 1310114004571 potential frameshift: common BLAST hit: gi|385994971|ref|YP_005913269.1| integral membrane protein 1310114004572 potential frameshift: common BLAST hit: gi|471337959|ref|YP_007610672.1| integral membrane protein 1310114004573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310114004574 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1310114004575 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1310114004576 homotetramer interface [polypeptide binding]; other site 1310114004577 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1310114004578 NAD binding site [chemical binding]; other site 1310114004579 homodimer interface [polypeptide binding]; other site 1310114004580 active site 1310114004581 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1310114004582 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1310114004583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1310114004584 Predicted kinase [General function prediction only]; Region: COG0645 1310114004585 AAA domain; Region: AAA_17; pfam13207 1310114004586 Universal stress protein family; Region: Usp; pfam00582 1310114004587 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114004588 Ligand Binding Site [chemical binding]; other site 1310114004589 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1310114004590 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1310114004591 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1310114004592 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1310114004593 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1310114004594 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1310114004595 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1310114004596 Ferredoxin [Energy production and conversion]; Region: COG1146 1310114004597 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310114004598 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1310114004599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114004600 Walker A motif; other site 1310114004601 ATP binding site [chemical binding]; other site 1310114004602 Walker B motif; other site 1310114004603 arginine finger; other site 1310114004604 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310114004605 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310114004606 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310114004607 MarR family; Region: MarR_2; pfam12802 1310114004608 Phage envelope protein [General function prediction only]; Region: COG5562 1310114004609 Predicted helicase [General function prediction only]; Region: COG4889 1310114004610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310114004611 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310114004612 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114004613 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114004614 active site 1310114004615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310114004616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310114004617 non-specific DNA binding site [nucleotide binding]; other site 1310114004618 salt bridge; other site 1310114004619 sequence-specific DNA binding site [nucleotide binding]; other site 1310114004620 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1310114004621 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1310114004622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310114004623 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310114004624 non-specific DNA binding site [nucleotide binding]; other site 1310114004625 salt bridge; other site 1310114004626 sequence-specific DNA binding site [nucleotide binding]; other site 1310114004627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1310114004628 Predicted helicase [General function prediction only]; Region: COG4889 1310114004629 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1310114004630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310114004631 putative Mg++ binding site [ion binding]; other site 1310114004632 Cation efflux family; Region: Cation_efflux; pfam01545 1310114004633 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1310114004634 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1310114004635 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114004636 Ligand Binding Site [chemical binding]; other site 1310114004637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114004638 Ligand Binding Site [chemical binding]; other site 1310114004639 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1310114004640 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1310114004641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310114004642 Histidine kinase; Region: HisKA_3; pfam07730 1310114004643 potential frameshift: common BLAST hit: gi|397673905|ref|YP_006515440.1| universal stress protein 1310114004644 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1310114004645 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1310114004646 putative substrate binding site [chemical binding]; other site 1310114004647 putative ATP binding site [chemical binding]; other site 1310114004648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310114004649 active site 1310114004650 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1310114004651 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1310114004652 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1310114004653 putative dimer interface [polypeptide binding]; other site 1310114004654 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310114004655 dimer interface [polypeptide binding]; other site 1310114004656 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1310114004657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114004658 putative DNA binding site [nucleotide binding]; other site 1310114004659 dimerization interface [polypeptide binding]; other site 1310114004660 putative Zn2+ binding site [ion binding]; other site 1310114004661 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1310114004662 putative hydrophobic ligand binding site [chemical binding]; other site 1310114004663 CLM binding site; other site 1310114004664 L1 loop; other site 1310114004665 DNA binding site [nucleotide binding] 1310114004666 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310114004667 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1310114004668 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1310114004669 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1310114004670 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1310114004671 nucleophile elbow; other site 1310114004672 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1310114004673 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310114004674 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1310114004675 Walker A/P-loop; other site 1310114004676 ATP binding site [chemical binding]; other site 1310114004677 Q-loop/lid; other site 1310114004678 ABC transporter signature motif; other site 1310114004679 Walker B; other site 1310114004680 D-loop; other site 1310114004681 H-loop/switch region; other site 1310114004682 TOBE domain; Region: TOBE_2; pfam08402 1310114004683 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310114004684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114004685 dimer interface [polypeptide binding]; other site 1310114004686 conserved gate region; other site 1310114004687 putative PBP binding loops; other site 1310114004688 ABC-ATPase subunit interface; other site 1310114004689 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1310114004690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114004691 dimer interface [polypeptide binding]; other site 1310114004692 conserved gate region; other site 1310114004693 putative PBP binding loops; other site 1310114004694 ABC-ATPase subunit interface; other site 1310114004695 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1310114004696 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1310114004697 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1310114004698 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1310114004699 Isochorismatase family; Region: Isochorismatase; pfam00857 1310114004700 catalytic triad [active] 1310114004701 metal binding site [ion binding]; metal-binding site 1310114004702 conserved cis-peptide bond; other site 1310114004703 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1310114004704 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310114004705 substrate binding pocket [chemical binding]; other site 1310114004706 catalytic triad [active] 1310114004707 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310114004708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114004709 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310114004710 Enoylreductase; Region: PKS_ER; smart00829 1310114004711 NAD(P) binding site [chemical binding]; other site 1310114004712 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1310114004713 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310114004714 putative NADP binding site [chemical binding]; other site 1310114004715 active site 1310114004716 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310114004717 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1310114004718 Enoylreductase; Region: PKS_ER; smart00829 1310114004719 NAD(P) binding site [chemical binding]; other site 1310114004720 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1310114004721 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1310114004722 putative NADP binding site [chemical binding]; other site 1310114004723 active site 1310114004724 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310114004725 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114004726 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310114004727 active site 1310114004728 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310114004729 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310114004730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114004731 potential frameshift: common BLAST hit: gi|385998828|ref|YP_005917126.1| polyketide synthase 1310114004732 potential frameshift: common BLAST hit: gi|449064102|ref|YP_007431185.1| polyketide synthase 1310114004733 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1310114004734 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1310114004735 putative active site [active] 1310114004736 putative dimer interface [polypeptide binding]; other site 1310114004737 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1310114004738 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1310114004739 Ligand binding site; other site 1310114004740 Putative Catalytic site; other site 1310114004741 DXD motif; other site 1310114004742 potential frameshift: common BLAST hit: gi|471338021|ref|YP_007610734.1| polyprenol-monophosphomannose synthase 1310114004743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310114004744 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310114004745 active site 1310114004746 potential frameshift: common BLAST hit: gi|471338023|ref|YP_007610736.1| inner membrane protein 1310114004747 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1310114004748 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1310114004749 30S ribosomal protein S18; Provisional; Region: PRK13401 1310114004750 potential frameshift: common BLAST hit: gi|471338027|ref|YP_007610740.1| 30S ribosomal protein S14 1310114004751 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1310114004752 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1310114004753 potential frameshift: common BLAST hit: gi|397673936|ref|YP_006515471.1| zinc/manganese transporter substrate-binding protein 1310114004754 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1310114004755 potential frameshift: common BLAST hit: gi|449064116|ref|YP_007431199.1| cobaltochelatase subunit CobN 1310114004756 potential frameshift: common BLAST hit: gi|385995032|ref|YP_005913330.1| cobaltochelatase subunit CobN 1310114004757 potential frameshift: common BLAST hit: gi|471338033|ref|YP_007610746.1| cobaltochelatase 1310114004758 potential frameshift: common BLAST hit: gi|385995032|ref|YP_005913330.1| cobaltochelatase subunit CobN 1310114004759 PemK-like protein; Region: PemK; pfam02452 1310114004760 potential frameshift: common BLAST hit: gi|471338036|ref|YP_007610749.1| cobalamin biosynthesis protein 1310114004761 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1310114004762 potential frameshift: common BLAST hit: gi|471338038|ref|YP_007610751.1| bifunctionalS-adenosyl-L-methionine-precorrin-2 1310114004763 potential frameshift: common BLAST hit: gi|433642226|ref|YP_007287985.1| Putative cobalamin biosynthesis protein cobIJ [Includes: 1310114004764 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310114004765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114004766 S-adenosylmethionine binding site [chemical binding]; other site 1310114004767 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1310114004768 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1310114004769 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1310114004770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114004771 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1310114004772 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1310114004773 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1310114004774 active site 1310114004775 SAM binding site [chemical binding]; other site 1310114004776 homodimer interface [polypeptide binding]; other site 1310114004777 potential frameshift: common BLAST hit: gi|471338044|ref|YP_007610757.1| precorrin-6y methyltransferase 1310114004778 potential frameshift: common BLAST hit: gi|15841561|ref|NP_336598.1| precorrin-6y c5,15-methyltransferase 1310114004779 potential frameshift: common BLAST hit: gi|471338045|ref|YP_007610758.1| shortchain dehydrogenase 1310114004780 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1310114004781 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1310114004782 catalytic site [active] 1310114004783 active site 1310114004784 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1310114004785 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310114004786 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1310114004787 putative transposase OrfB; Reviewed; Region: PHA02517 1310114004788 potential frameshift: common BLAST hit: gi|471338063|ref|YP_007610776.1| transmembrane serine/threonine-protein kinase J 1310114004789 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1310114004790 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1310114004791 active site 1310114004792 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1310114004793 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1310114004794 active site 1310114004795 metal binding site 1 [ion binding]; metal-binding site 1310114004796 putative 5' ssDNA interaction site; other site 1310114004797 metal binding site 3; metal-binding site 1310114004798 metal binding site 2 [ion binding]; metal-binding site 1310114004799 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1310114004800 putative DNA binding site [nucleotide binding]; other site 1310114004801 putative metal binding site [ion binding]; other site 1310114004802 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1310114004803 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1310114004804 potential frameshift: common BLAST hit: gi|471338067|ref|YP_007610780.1| ATP-dependent DNA helicase 1310114004805 potential frameshift: common BLAST hit: gi|471338067|ref|YP_007610780.1| ATP-dependent DNA helicase 1310114004806 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1310114004807 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1310114004808 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1310114004809 potential frameshift: common BLAST hit: gi|397673975|ref|YP_006515510.1| protein pafC 1310114004810 potential frameshift: common BLAST hit: gi|397673975|ref|YP_006515510.1| protein pafC 1310114004811 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1310114004812 potential frameshift: common BLAST hit: gi|471338073|ref|YP_007610786.1| PE-PGRS family protein 1310114004813 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1310114004814 SNF2 Helicase protein; Region: DUF3670; pfam12419 1310114004815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310114004816 ATP binding site [chemical binding]; other site 1310114004817 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1310114004818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1310114004819 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1310114004820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1310114004821 ATP-binding site [chemical binding]; other site 1310114004822 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310114004823 putative active site [active] 1310114004824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114004825 Transposase; Region: HTH_Tnp_1; cl17663 1310114004826 putative transposase OrfB; Reviewed; Region: PHA02517 1310114004827 HTH-like domain; Region: HTH_21; pfam13276 1310114004828 Integrase core domain; Region: rve; pfam00665 1310114004829 Integrase core domain; Region: rve_3; pfam13683 1310114004830 PE family; Region: PE; pfam00934 1310114004831 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114004832 PPE family; Region: PPE; pfam00823 1310114004833 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1310114004834 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1310114004835 active site 1310114004836 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1310114004837 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1310114004838 active site 1310114004839 Pup-like protein; Region: Pup; pfam05639 1310114004840 Pup-ligase protein; Region: Pup_ligase; cl15463 1310114004841 Pup-ligase protein; Region: Pup_ligase; cl15463 1310114004842 proteasome ATPase; Region: pup_AAA; TIGR03689 1310114004843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114004844 Walker A motif; other site 1310114004845 ATP binding site [chemical binding]; other site 1310114004846 Walker B motif; other site 1310114004847 arginine finger; other site 1310114004848 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1310114004849 Protein of unknown function (DUF503); Region: DUF503; cl00669 1310114004850 potential frameshift: common BLAST hit: gi|471338091|ref|YP_007610804.1| RNA methyltransferase 1310114004851 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1310114004852 Predicted membrane protein [Function unknown]; Region: COG3918 1310114004853 potential frameshift: common BLAST hit: gi|471338094|ref|YP_007610807.1| ATP phosphoribosyltransferase 1310114004854 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1310114004855 homodimer interface [polypeptide binding]; other site 1310114004856 putative metal binding site [ion binding]; other site 1310114004857 potential frameshift: common BLAST hit: gi|471338096|ref|YP_007610809.1| PPE family protein 1310114004858 potential frameshift: common BLAST hit: gi|471338097|ref|YP_007610810.1| 5-methyltetrahydrofolate-homocysteinmethyltransferase 1310114004859 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1310114004860 PAC2 family; Region: PAC2; pfam09754 1310114004861 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1310114004862 potential frameshift: common BLAST hit: gi|471338103|ref|YP_007610816.1| short chain dehydrogenase 1310114004863 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1310114004864 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114004865 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 1310114004866 active site 1310114004867 HIGH motif; other site 1310114004868 nucleotide binding site [chemical binding]; other site 1310114004869 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114004870 active site 1310114004871 KMSKS motif; other site 1310114004872 potential frameshift: common BLAST hit: gi|471338105|ref|YP_007610818.1| monophosphatase 1310114004873 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114004874 conserved hypothetical protein; Region: TIGR03843 1310114004875 conserved hypothetical protein; Region: TIGR03847 1310114004876 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310114004877 catalytic core [active] 1310114004878 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1310114004879 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310114004880 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310114004881 phosphate binding site [ion binding]; other site 1310114004882 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1310114004883 substrate binding site [chemical binding]; other site 1310114004884 hypothetical protein; Provisional; Region: PRK07906 1310114004885 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1310114004886 putative metal binding site [ion binding]; other site 1310114004887 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1310114004888 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1310114004889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310114004890 active site 1310114004891 Predicted integral membrane protein [Function unknown]; Region: COG0762 1310114004892 Protein of unknown function (DUF552); Region: DUF552; cl00775 1310114004893 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1310114004894 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310114004895 catalytic residue [active] 1310114004896 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1310114004897 cell division protein FtsZ; Validated; Region: PRK09330 1310114004898 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1310114004899 nucleotide binding site [chemical binding]; other site 1310114004900 SulA interaction site; other site 1310114004901 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1310114004902 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1310114004903 Cell division protein FtsQ; Region: FtsQ; pfam03799 1310114004904 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1310114004905 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310114004906 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310114004907 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1310114004908 potential frameshift: common BLAST hit: gi|471338128|ref|YP_007610841.1| N-acetylglucosaminyl transferase 1310114004909 cell division protein FtsW; Region: ftsW; TIGR02614 1310114004910 potential frameshift: common BLAST hit: gi|385995117|ref|YP_005913415.1| UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1310114004911 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1310114004912 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1310114004913 Mg++ binding site [ion binding]; other site 1310114004914 putative catalytic motif [active] 1310114004915 putative substrate binding site [chemical binding]; other site 1310114004916 potential frameshift: common BLAST hit: gi|471338132|ref|YP_007610845.1| UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate- 1310114004917 potential frameshift: common BLAST hit: gi|386005096|ref|YP_005923375.1| UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1310114004918 potential frameshift: common BLAST hit: gi|386005096|ref|YP_005923375.1| UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1310114004919 potential frameshift: common BLAST hit: gi|449064216|ref|YP_007431299.1| UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1310114004920 potential frameshift: common BLAST hit: gi|449064216|ref|YP_007431299.1| UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1310114004921 potential frameshift: common BLAST hit: gi|397674043|ref|YP_006515578.1| alkylhydroperoxidase AhpD family core domain-containing protein 1310114004922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114004923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114004924 PE family; Region: PE; pfam00934 1310114004925 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1310114004926 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1310114004927 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310114004928 MraW methylase family; Region: Methyltransf_5; cl17771 1310114004929 MraW methylase family; Region: Methyltransf_5; cl17771 1310114004930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1310114004931 MraZ protein; Region: MraZ; pfam02381 1310114004932 MraZ protein; Region: MraZ; pfam02381 1310114004933 putative transposase OrfB; Reviewed; Region: PHA02517 1310114004934 HTH-like domain; Region: HTH_21; pfam13276 1310114004935 Integrase core domain; Region: rve; pfam00665 1310114004936 Integrase core domain; Region: rve_3; pfam13683 1310114004937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114004938 Transposase; Region: HTH_Tnp_1; cl17663 1310114004939 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1310114004940 potential frameshift: common BLAST hit: gi|433642349|ref|YP_007288108.1| Gcn5-related N-acetyltransferase 1310114004941 potential frameshift: common BLAST hit: gi|433642349|ref|YP_007288108.1| Gcn5-related N-acetyltransferase 1310114004942 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1310114004943 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310114004944 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310114004945 substrate binding pocket [chemical binding]; other site 1310114004946 chain length determination region; other site 1310114004947 substrate-Mg2+ binding site; other site 1310114004948 catalytic residues [active] 1310114004949 aspartate-rich region 1; other site 1310114004950 active site lid residues [active] 1310114004951 aspartate-rich region 2; other site 1310114004952 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1310114004953 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310114004954 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310114004955 active site 1310114004956 ATP binding site [chemical binding]; other site 1310114004957 substrate binding site [chemical binding]; other site 1310114004958 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1310114004959 substrate binding site [chemical binding]; other site 1310114004960 activation loop (A-loop); other site 1310114004961 activation loop (A-loop); other site 1310114004962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310114004963 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310114004964 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1310114004965 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1310114004966 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114004967 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310114004968 putative acyl-acceptor binding pocket; other site 1310114004969 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1310114004970 putative hydrophobic ligand binding site [chemical binding]; other site 1310114004971 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1310114004972 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1310114004973 acyl-activating enzyme (AAE) consensus motif; other site 1310114004974 putative AMP binding site [chemical binding]; other site 1310114004975 putative active site [active] 1310114004976 putative CoA binding site [chemical binding]; other site 1310114004977 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310114004978 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1310114004979 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310114004980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310114004981 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1310114004982 hypothetical protein; Validated; Region: PRK07883 1310114004983 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1310114004984 active site 1310114004985 catalytic site [active] 1310114004986 substrate binding site [chemical binding]; other site 1310114004987 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1310114004988 GIY-YIG motif/motif A; other site 1310114004989 active site 1310114004990 catalytic site [active] 1310114004991 putative DNA binding site [nucleotide binding]; other site 1310114004992 metal binding site [ion binding]; metal-binding site 1310114004993 hypothetical protein; Validated; Region: PRK07883 1310114004994 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1310114004995 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1310114004996 Subunit I/III interface [polypeptide binding]; other site 1310114004997 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1310114004998 Cytochrome c; Region: Cytochrom_C; pfam00034 1310114004999 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1310114005000 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1310114005001 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1310114005002 iron-sulfur cluster [ion binding]; other site 1310114005003 [2Fe-2S] cluster binding site [ion binding]; other site 1310114005004 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1310114005005 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1310114005006 heme bH binding site [chemical binding]; other site 1310114005007 intrachain domain interface; other site 1310114005008 heme bL binding site [chemical binding]; other site 1310114005009 interchain domain interface [polypeptide binding]; other site 1310114005010 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1310114005011 Qo binding site; other site 1310114005012 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1310114005013 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1310114005014 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1310114005015 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1310114005016 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1310114005017 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1310114005018 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1310114005019 dimer interface [polypeptide binding]; other site 1310114005020 active site 1310114005021 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1310114005022 Ligand Binding Site [chemical binding]; other site 1310114005023 Molecular Tunnel; other site 1310114005024 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1310114005025 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1310114005026 substrate binding site [chemical binding]; other site 1310114005027 ATP binding site [chemical binding]; other site 1310114005028 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1310114005029 Glycerate kinase family; Region: Gly_kinase; cl00841 1310114005030 Glycerate kinase family; Region: Gly_kinase; cl00841 1310114005031 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1310114005032 potential frameshift: common BLAST hit: gi|471338181|ref|YP_007610894.1| nicotinate-nucleotide- 1310114005033 potential frameshift: common BLAST hit: gi|471338181|ref|YP_007610894.1| nicotinate-nucleotide- 1310114005034 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1310114005035 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1310114005036 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1310114005037 homodimer interface [polypeptide binding]; other site 1310114005038 substrate-cofactor binding pocket; other site 1310114005039 catalytic residue [active] 1310114005040 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1310114005041 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1310114005042 cyclase homology domain; Region: CHD; cd07302 1310114005043 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1310114005044 nucleotidyl binding site; other site 1310114005045 metal binding site [ion binding]; metal-binding site 1310114005046 dimer interface [polypeptide binding]; other site 1310114005047 potential frameshift: common BLAST hit: gi|471338187|ref|YP_007610900.1| leucyl aminopeptidase 1310114005048 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 1310114005049 potential frameshift: common BLAST hit: gi|471338188|ref|YP_007610901.1| short chain dehydrogenase 1310114005050 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310114005051 E3 interaction surface; other site 1310114005052 lipoyl attachment site [posttranslational modification]; other site 1310114005053 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310114005054 E3 interaction surface; other site 1310114005055 lipoyl attachment site [posttranslational modification]; other site 1310114005056 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310114005057 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1310114005058 lipoyl synthase; Provisional; Region: PRK05481 1310114005059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114005060 FeS/SAM binding site; other site 1310114005061 potential frameshift: common BLAST hit: gi|471338193|ref|YP_007610906.1| transmembrane protein 1310114005062 RDD family; Region: RDD; pfam06271 1310114005063 glutamine synthetase, type I; Region: GlnA; TIGR00653 1310114005064 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1310114005065 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310114005066 potential frameshift: common BLAST hit: gi|471338196|ref|YP_007610909.1| glutamate-ammonia-ligase adenylyltransferase 1310114005067 potential frameshift: common BLAST hit: gi|471338196|ref|YP_007610909.1| glutamate-ammonia-ligase adenylyltransferase 1310114005068 potential frameshift: common BLAST hit: gi|471338196|ref|YP_007610909.1| glutamate-ammonia-ligase adenylyltransferase 1310114005069 potential frameshift: common BLAST hit: gi|433631340|ref|YP_007264968.1| Glutamate-ammonia-ligase adenylyltransferase GlnE 1310114005070 potential frameshift: common BLAST hit: gi|471338196|ref|YP_007610909.1| glutamate-ammonia-ligase adenylyltransferase 1310114005071 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1310114005072 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310114005073 potential frameshift: common BLAST hit: gi|471338198|ref|YP_007610911.1| exported protease 1310114005074 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1310114005075 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310114005076 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114005077 potential frameshift: common BLAST hit: gi|385995187|ref|YP_005913485.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase 1310114005078 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 1310114005079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1310114005080 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1310114005081 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1310114005082 RNA/DNA hybrid binding site [nucleotide binding]; other site 1310114005083 active site 1310114005084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310114005085 catalytic core [active] 1310114005086 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1310114005087 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1310114005088 hypothetical protein; Provisional; Region: PRK07908 1310114005089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310114005090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114005091 homodimer interface [polypeptide binding]; other site 1310114005092 catalytic residue [active] 1310114005093 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1310114005094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1310114005095 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1310114005096 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310114005097 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 1310114005098 potential frameshift: common BLAST hit: gi|397674120|ref|YP_006515655.1| 5'-nucleotidase 1310114005099 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1310114005100 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1310114005101 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1310114005102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1310114005103 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1310114005104 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1310114005105 dimer interface [polypeptide binding]; other site 1310114005106 catalytic triad [active] 1310114005107 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1310114005108 potential frameshift: common BLAST hit: gi|471338221|ref|YP_007610934.1| pyruvate dehydrogenase subunit E1 1310114005109 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310114005110 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310114005111 potential frameshift: common BLAST hit: gi|433627364|ref|YP_007260993.1| Malonyl CoA-acyl carrier protein transacylase 1310114005112 potential frameshift: common BLAST hit: gi|471338223|ref|YP_007610936.1| acyl-carrier-protein S-malonyltransferase 1310114005113 potential frameshift: common BLAST hit: gi|471338223|ref|YP_007610936.1| acyl-carrier-protein S-malonyltransferase 1310114005114 acyl carrier protein; Provisional; Region: acpP; PRK00982 1310114005115 potential frameshift: common BLAST hit: gi|449064305|ref|YP_007431388.1| 3-oxoacyl-(acyl carrier protein) synthase II 1310114005116 potential frameshift: common BLAST hit: gi|449064306|ref|YP_007431389.1| 3-oxoacyl-ACP synthase II 1310114005117 potential frameshift: common BLAST hit: gi|471338227|ref|YP_007610940.1| acetyl/propionyl-CoA carboxylase beta subunit 1310114005118 potential frameshift: common BLAST hit: gi|449064309|ref|YP_007431392.1| glycerol-3-phosphate dehydrogenase 1310114005119 potential frameshift: common BLAST hit: gi|449064309|ref|YP_007431392.1| glycerol-3-phosphate dehydrogenase 1310114005120 potential frameshift: common BLAST hit: gi|339632277|ref|YP_004723919.1| flavoprotein 1310114005121 diacylglycerol kinase; Reviewed; Region: PRK11914 1310114005122 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1310114005123 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1310114005124 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114005125 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114005126 potential frameshift: common BLAST hit: gi|471338238|ref|YP_007610951.1| transcriptional regulator 1310114005127 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114005128 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310114005129 potential frameshift: common BLAST hit: gi|253798671|ref|YP_003031672.1| apolipoprotein N-acyltransferase 1310114005130 potential frameshift: common BLAST hit: gi|471338241|ref|YP_007610954.1| short chain dehydrogenase 1310114005131 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310114005132 nucleotide binding site [chemical binding]; other site 1310114005133 potential frameshift: common BLAST hit: gi|471338244|ref|YP_007610957.1| integral membrane protein 1310114005134 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114005135 Cytochrome P450; Region: p450; cl12078 1310114005136 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1310114005137 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114005138 Cytochrome P450; Region: p450; cl12078 1310114005139 Septum formation; Region: Septum_form; pfam13845 1310114005140 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1310114005141 Predicted membrane protein [Function unknown]; Region: COG2149 1310114005142 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114005143 Cytochrome P450; Region: p450; cl12078 1310114005144 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1310114005145 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1310114005146 putative active site [active] 1310114005147 catalytic site [active] 1310114005148 putative metal binding site [ion binding]; other site 1310114005149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114005150 Transposase; Region: HTH_Tnp_1; cl17663 1310114005151 putative transposase OrfB; Reviewed; Region: PHA02517 1310114005152 HTH-like domain; Region: HTH_21; pfam13276 1310114005153 Integrase core domain; Region: rve; pfam00665 1310114005154 Integrase core domain; Region: rve_3; pfam13683 1310114005155 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1310114005156 FAD binding domain; Region: FAD_binding_4; pfam01565 1310114005157 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1310114005158 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1310114005159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310114005160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310114005161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310114005162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310114005163 dimerization interface [polypeptide binding]; other site 1310114005164 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310114005165 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310114005166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310114005167 Secretory lipase; Region: LIP; pfam03583 1310114005168 potential frameshift: common BLAST hit: gi|433642472|ref|YP_007288231.1| Putative triacylglycerol synthase (diacylglycerol acyltransferase) 1310114005169 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1310114005170 potential frameshift: common BLAST hit: gi|449064346|ref|YP_007431429.1| integral membrane transport protein 1310114005171 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1310114005172 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310114005173 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310114005174 active site residue [active] 1310114005175 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310114005176 active site residue [active] 1310114005177 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1310114005178 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1310114005179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310114005180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114005181 homodimer interface [polypeptide binding]; other site 1310114005182 catalytic residue [active] 1310114005183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1310114005184 haloalkane dehalogenase; Provisional; Region: PRK00870 1310114005185 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310114005186 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310114005187 active site 1310114005188 catalytic tetrad [active] 1310114005189 heat shock protein 90; Provisional; Region: PRK05218 1310114005190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114005191 ATP binding site [chemical binding]; other site 1310114005192 Mg2+ binding site [ion binding]; other site 1310114005193 G-X-G motif; other site 1310114005194 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310114005195 Cutinase; Region: Cutinase; pfam01083 1310114005196 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1310114005197 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1310114005198 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1310114005199 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1310114005200 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1310114005201 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310114005202 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1310114005203 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310114005204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1310114005205 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1310114005206 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310114005207 DNA binding site [nucleotide binding] 1310114005208 active site 1310114005209 Int/Topo IB signature motif; other site 1310114005210 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310114005211 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1310114005212 DNA binding residues [nucleotide binding] 1310114005213 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310114005214 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1310114005215 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1310114005216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114005217 putative PBP binding loops; other site 1310114005218 ABC-ATPase subunit interface; other site 1310114005219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310114005220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114005221 dimer interface [polypeptide binding]; other site 1310114005222 conserved gate region; other site 1310114005223 putative PBP binding loops; other site 1310114005224 ABC-ATPase subunit interface; other site 1310114005225 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1310114005226 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1310114005227 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114005228 Ligand Binding Site [chemical binding]; other site 1310114005229 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114005230 Ligand Binding Site [chemical binding]; other site 1310114005231 amino acid transporter; Region: 2A0306; TIGR00909 1310114005232 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1310114005233 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1310114005234 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114005235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114005236 catalytic residue [active] 1310114005237 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114005238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114005239 Amidinotransferase; Region: Amidinotransf; pfam02274 1310114005240 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1310114005241 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1310114005242 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1310114005243 putative DNA binding site [nucleotide binding]; other site 1310114005244 putative Zn2+ binding site [ion binding]; other site 1310114005245 AsnC family; Region: AsnC_trans_reg; pfam01037 1310114005246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114005247 ABC transporter signature motif; other site 1310114005248 Walker B; other site 1310114005249 D-loop; other site 1310114005250 H-loop/switch region; other site 1310114005251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114005252 Walker A/P-loop; other site 1310114005253 ATP binding site [chemical binding]; other site 1310114005254 ABC transporter; Region: ABC_tran; pfam00005 1310114005255 Q-loop/lid; other site 1310114005256 ABC transporter signature motif; other site 1310114005257 Walker B; other site 1310114005258 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1310114005259 potential frameshift: common BLAST hit: gi|385995276|ref|YP_005913574.1| transmembrane ABC transporter ATP-binding protein 1310114005260 MarR family; Region: MarR; pfam01047 1310114005261 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310114005262 PE family; Region: PE; pfam00934 1310114005263 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1310114005264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114005265 putative substrate translocation pore; other site 1310114005266 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1310114005267 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114005268 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1310114005269 malate dehydrogenase; Provisional; Region: PRK13529 1310114005270 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1310114005271 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1310114005272 NAD(P) binding site [chemical binding]; other site 1310114005273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114005274 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310114005275 putative substrate translocation pore; other site 1310114005276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114005277 putative substrate translocation pore; other site 1310114005278 potential frameshift: common BLAST hit: gi|471338314|ref|YP_007611027.1| cysteine synthase A 1310114005279 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1310114005280 serine O-acetyltransferase; Region: cysE; TIGR01172 1310114005281 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1310114005282 trimer interface [polypeptide binding]; other site 1310114005283 active site 1310114005284 substrate binding site [chemical binding]; other site 1310114005285 CoA binding site [chemical binding]; other site 1310114005286 hypothetical protein; Provisional; Region: PRK14851 1310114005287 hypothetical protein; Validated; Region: PRK08223 1310114005288 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1310114005289 ATP binding site [chemical binding]; other site 1310114005290 substrate interface [chemical binding]; other site 1310114005291 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310114005292 PE family; Region: PE; pfam00934 1310114005293 potential frameshift: common BLAST hit: gi|471338326|ref|YP_007611039.1| DNA primase 1310114005294 potential frameshift: common BLAST hit: gi|471338326|ref|YP_007611039.1| DNA primase 1310114005295 potential frameshift: common BLAST hit: gi|471338326|ref|YP_007611039.1| DNA primase 1310114005296 potential frameshift: common BLAST hit: gi|471338326|ref|YP_007611039.1| DNA primase 1310114005297 potential frameshift: common BLAST hit: gi|471338327|ref|YP_007611040.1| deoxyguanosinetriphosphatetriphosphohydrolase-like protein 1310114005298 potential frameshift: common BLAST hit: gi|471338328|ref|YP_007611041.1| transmembrane protein 1310114005299 pseudaminic acid synthase; Region: PseI; TIGR03586 1310114005300 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310114005301 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1310114005302 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1310114005303 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1310114005304 potential frameshift: common BLAST hit: gi|471338333|ref|YP_007611046.1| membrane-associated phospholipase C 1310114005305 potential frameshift: common BLAST hit: gi|471338334|ref|YP_007611047.1| membrane-associated phospholipase C 1310114005306 PPE family; Region: PPE; pfam00823 1310114005307 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114005308 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114005309 PPE family; Region: PPE; pfam00823 1310114005310 PPE family; Region: PPE; pfam00823 1310114005311 PPE family; Region: PPE; pfam00823 1310114005312 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1310114005313 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310114005314 motif 1; other site 1310114005315 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1310114005316 active site 1310114005317 motif 2; other site 1310114005318 motif 3; other site 1310114005319 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1310114005320 anticodon binding site; other site 1310114005321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114005322 dimerization interface [polypeptide binding]; other site 1310114005323 putative DNA binding site [nucleotide binding]; other site 1310114005324 putative Zn2+ binding site [ion binding]; other site 1310114005325 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1310114005326 metal binding site 2 [ion binding]; metal-binding site 1310114005327 putative DNA binding helix; other site 1310114005328 metal binding site 1 [ion binding]; metal-binding site 1310114005329 dimer interface [polypeptide binding]; other site 1310114005330 structural Zn2+ binding site [ion binding]; other site 1310114005331 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1310114005332 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1310114005333 catalytic residue [active] 1310114005334 putative FPP diphosphate binding site; other site 1310114005335 putative FPP binding hydrophobic cleft; other site 1310114005336 dimer interface [polypeptide binding]; other site 1310114005337 putative IPP diphosphate binding site; other site 1310114005338 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1310114005339 Recombination protein O N terminal; Region: RecO_N; pfam11967 1310114005340 Recombination protein O C terminal; Region: RecO_C; pfam02565 1310114005341 potential frameshift: common BLAST hit: gi|471338349|ref|YP_007611062.1| amidase 1310114005342 potential frameshift: common BLAST hit: gi|471338349|ref|YP_007611062.1| amidase 1310114005343 GTPase Era; Reviewed; Region: era; PRK00089 1310114005344 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1310114005345 G1 box; other site 1310114005346 GTP/Mg2+ binding site [chemical binding]; other site 1310114005347 Switch I region; other site 1310114005348 G2 box; other site 1310114005349 Switch II region; other site 1310114005350 G3 box; other site 1310114005351 G4 box; other site 1310114005352 G5 box; other site 1310114005353 KH domain; Region: KH_2; pfam07650 1310114005354 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310114005355 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310114005356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310114005357 Transporter associated domain; Region: CorC_HlyC; smart01091 1310114005358 potential frameshift: common BLAST hit: gi|471338353|ref|YP_007611066.1| putative metalloprotease 1310114005359 K homology RNA-binding domain; Region: KH; smart00322 1310114005360 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1310114005361 PhoH-like protein; Region: PhoH; pfam02562 1310114005362 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310114005363 PE family; Region: PE; pfam00934 1310114005364 potential frameshift: common BLAST hit: gi|449064433|ref|YP_007431516.1| 16S ribosomal RNA methyltransferase RsmE 1310114005365 chaperone protein DnaJ; Provisional; Region: PRK14278 1310114005366 chaperone protein DnaJ; Provisional; Region: PRK14278 1310114005367 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1310114005368 HSP70 interaction site [polypeptide binding]; other site 1310114005369 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1310114005370 Zn binding sites [ion binding]; other site 1310114005371 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1310114005372 dimer interface [polypeptide binding]; other site 1310114005373 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1310114005374 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310114005375 potential frameshift: common BLAST hit: gi|471338364|ref|YP_007611077.1| low molecular weight antigen 1310114005376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1310114005377 potential frameshift: common BLAST hit: gi|471338366|ref|YP_007611079.1| lysine-N-oxygenase 1310114005378 potential frameshift: common BLAST hit: gi|392432014|ref|YP_006473058.1| peptide synthetase mbtF 1310114005379 potential frameshift: common BLAST hit: gi|449064440|ref|YP_007431523.1| peptide synthetase MBTF (peptide synthase) 1310114005380 potential frameshift: common BLAST hit: gi|449064440|ref|YP_007431523.1| peptide synthetase MBTF (peptide synthase) 1310114005381 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1310114005382 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1310114005383 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1310114005384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114005385 potential frameshift: common BLAST hit: gi|471338368|ref|YP_007611081.1| peptide synthetase MBTE (peptide synthase) 1310114005386 potential frameshift: common BLAST hit: gi|433635462|ref|YP_007269089.1| Polyketide synthetase MbtD (polyketide synthase) 1310114005387 potential frameshift: common BLAST hit: gi|15841893|ref|NP_336930.1| polyketide synthase 1310114005388 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114005389 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310114005390 active site 1310114005391 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1310114005392 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114005393 CoA binding site [chemical binding]; other site 1310114005394 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310114005395 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114005396 active site 1310114005397 AMP binding site [chemical binding]; other site 1310114005398 potential frameshift: common BLAST hit: gi|471338371|ref|YP_007611084.1| phenyloxazoline synthase 1310114005399 potential frameshift: common BLAST hit: gi|471338371|ref|YP_007611084.1| phenyloxazoline synthase 1310114005400 potential frameshift: common BLAST hit: gi|471338372|ref|YP_007611085.1| bifunctional salicyl-AMP ligase/salicyl-S-arcpsynthetase 1310114005401 potential frameshift: common BLAST hit: gi|433635465|ref|YP_007269092.1| Bifunctional enzyme MbtA: salicyl-AMP ligase (Sal-AMP 1310114005402 potential frameshift: common BLAST hit: gi|471338373|ref|YP_007611086.1| putative acetyl hydrolase 1310114005403 potential frameshift: common BLAST hit: gi|471338374|ref|YP_007611087.1| salicylate synthase 1310114005404 Predicted permease [General function prediction only]; Region: COG3329 1310114005405 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1310114005406 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310114005407 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1310114005408 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1310114005409 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1310114005410 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1310114005411 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1310114005412 Active Sites [active] 1310114005413 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1310114005414 putative active site [active] 1310114005415 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1310114005416 putative active site [active] 1310114005417 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1310114005418 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1310114005419 Predicted membrane protein [Function unknown]; Region: COG1297 1310114005420 putative oligopeptide transporter, OPT family; Region: TIGR00733 1310114005421 PE family; Region: PE; pfam00934 1310114005422 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1310114005423 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1310114005424 Walker A/P-loop; other site 1310114005425 ATP binding site [chemical binding]; other site 1310114005426 Q-loop/lid; other site 1310114005427 ABC transporter signature motif; other site 1310114005428 Walker B; other site 1310114005429 D-loop; other site 1310114005430 H-loop/switch region; other site 1310114005431 sulfate transport protein; Provisional; Region: cysT; CHL00187 1310114005432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114005433 dimer interface [polypeptide binding]; other site 1310114005434 conserved gate region; other site 1310114005435 putative PBP binding loops; other site 1310114005436 ABC-ATPase subunit interface; other site 1310114005437 sulfate transport protein; Provisional; Region: cysT; CHL00187 1310114005438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114005439 dimer interface [polypeptide binding]; other site 1310114005440 conserved gate region; other site 1310114005441 putative PBP binding loops; other site 1310114005442 ABC-ATPase subunit interface; other site 1310114005443 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1310114005444 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1310114005445 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310114005446 GTP-binding protein LepA; Provisional; Region: PRK05433 1310114005447 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1310114005448 G1 box; other site 1310114005449 putative GEF interaction site [polypeptide binding]; other site 1310114005450 GTP/Mg2+ binding site [chemical binding]; other site 1310114005451 Switch I region; other site 1310114005452 G2 box; other site 1310114005453 G3 box; other site 1310114005454 Switch II region; other site 1310114005455 G4 box; other site 1310114005456 G5 box; other site 1310114005457 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1310114005458 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1310114005459 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1310114005460 PemK-like protein; Region: PemK; pfam02452 1310114005461 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1310114005462 FOG: CBS domain [General function prediction only]; Region: COG0517 1310114005463 ribonuclease Z; Reviewed; Region: PRK00055 1310114005464 PE family; Region: PE; pfam00934 1310114005465 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310114005466 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1310114005467 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1310114005468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1310114005469 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1310114005470 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1310114005471 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1310114005472 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1310114005473 Competence protein; Region: Competence; pfam03772 1310114005474 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1310114005475 Helix-hairpin-helix motif; Region: HHH; pfam00633 1310114005476 potential frameshift: common BLAST hit: gi|449064482|ref|YP_007431565.1| enhanced intracellular survival protein eis 1310114005477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1310114005478 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1310114005479 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1310114005480 active site 1310114005481 catalytic triad [active] 1310114005482 oxyanion hole [active] 1310114005483 potential frameshift: common BLAST hit: gi|449064485|ref|YP_007431568.1| phosphoglycerate mutase (phosphoglyceromutase) 1310114005484 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1310114005485 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1310114005486 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1310114005487 active site 1310114005488 (T/H)XGH motif; other site 1310114005489 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310114005490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114005491 S-adenosylmethionine binding site [chemical binding]; other site 1310114005492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310114005493 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310114005494 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1310114005495 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310114005496 metal ion-dependent adhesion site (MIDAS); other site 1310114005497 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1310114005498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114005499 Walker A motif; other site 1310114005500 ATP binding site [chemical binding]; other site 1310114005501 Walker B motif; other site 1310114005502 arginine finger; other site 1310114005503 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1310114005504 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1310114005505 putative catalytic cysteine [active] 1310114005506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310114005507 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1310114005508 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1310114005509 dimer interface [polypeptide binding]; other site 1310114005510 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1310114005511 catalytic triad [active] 1310114005512 peroxidatic and resolving cysteines [active] 1310114005513 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1310114005514 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1310114005515 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114005516 PPE family; Region: PPE; pfam00823 1310114005517 PE family; Region: PE; pfam00934 1310114005518 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1310114005519 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1310114005520 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310114005521 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310114005522 ligand binding site [chemical binding]; other site 1310114005523 flexible hinge region; other site 1310114005524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310114005525 dimerization interface [polypeptide binding]; other site 1310114005526 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1310114005527 cyclase homology domain; Region: CHD; cd07302 1310114005528 nucleotidyl binding site; other site 1310114005529 metal binding site [ion binding]; metal-binding site 1310114005530 dimer interface [polypeptide binding]; other site 1310114005531 alpha-dioxygenase; Region: PLN02283 1310114005532 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1310114005533 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1310114005534 substrate binding site [chemical binding]; other site 1310114005535 dimer interface [polypeptide binding]; other site 1310114005536 ATP binding site [chemical binding]; other site 1310114005537 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1310114005538 NAD synthetase; Reviewed; Region: nadE; PRK02628 1310114005539 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1310114005540 multimer interface [polypeptide binding]; other site 1310114005541 active site 1310114005542 catalytic triad [active] 1310114005543 protein interface 1 [polypeptide binding]; other site 1310114005544 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1310114005545 homodimer interface [polypeptide binding]; other site 1310114005546 NAD binding pocket [chemical binding]; other site 1310114005547 ATP binding pocket [chemical binding]; other site 1310114005548 Mg binding site [ion binding]; other site 1310114005549 active-site loop [active] 1310114005550 gamma-glutamyl kinase; Provisional; Region: PRK05429 1310114005551 potential frameshift: common BLAST hit: gi|397674341|ref|YP_006515876.1| glutamate 5-kinase 1310114005552 potential frameshift: common BLAST hit: gi|471338439|ref|YP_007611152.1| GTPase 1310114005553 potential frameshift: common BLAST hit: gi|471338439|ref|YP_007611152.1| GTPase 1310114005554 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1310114005555 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1310114005556 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1310114005557 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1310114005558 potential frameshift: common BLAST hit: gi|471338443|ref|YP_007611156.1| ribonuclease E 1310114005559 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1310114005560 active site 1310114005561 multimer interface [polypeptide binding]; other site 1310114005562 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1310114005563 potential frameshift: common BLAST hit: gi|471338446|ref|YP_007611159.1| folylpolyglutamate synthase protein 1310114005564 potential frameshift: common BLAST hit: gi|471338446|ref|YP_007611159.1| folylpolyglutamate synthase protein 1310114005565 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1310114005566 tRNA binding surface [nucleotide binding]; other site 1310114005567 anticodon binding site; other site 1310114005568 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1310114005569 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1310114005570 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114005571 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1310114005572 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114005573 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114005574 active site 1310114005575 HIGH motif; other site 1310114005576 nucleotide binding site [chemical binding]; other site 1310114005577 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1310114005578 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1310114005579 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1310114005580 NAD(P) binding pocket [chemical binding]; other site 1310114005581 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310114005582 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1310114005583 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1310114005584 GTP binding site; other site 1310114005585 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1310114005586 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1310114005587 TPP-binding site [chemical binding]; other site 1310114005588 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1310114005589 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1310114005590 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1310114005591 dimer interface [polypeptide binding]; other site 1310114005592 PYR/PP interface [polypeptide binding]; other site 1310114005593 TPP binding site [chemical binding]; other site 1310114005594 substrate binding site [chemical binding]; other site 1310114005595 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1310114005596 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1310114005597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114005598 Walker A motif; other site 1310114005599 ATP binding site [chemical binding]; other site 1310114005600 Walker B motif; other site 1310114005601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1310114005602 potential frameshift: common BLAST hit: gi|449064528|ref|YP_007431611.1| homocysteine methyltransferase 1310114005603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114005604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310114005605 putative substrate translocation pore; other site 1310114005606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114005607 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1310114005608 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1310114005609 oligomer interface [polypeptide binding]; other site 1310114005610 active site residues [active] 1310114005611 Clp protease; Region: CLP_protease; pfam00574 1310114005612 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1310114005613 oligomer interface [polypeptide binding]; other site 1310114005614 active site residues [active] 1310114005615 trigger factor; Provisional; Region: tig; PRK01490 1310114005616 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1310114005617 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1310114005618 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 1310114005619 potential frameshift: common BLAST hit: gi|471338462|ref|YP_007611175.1| esterase 1310114005620 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1310114005621 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1310114005622 DNA binding site [nucleotide binding] 1310114005623 putative catalytic residues [active] 1310114005624 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310114005625 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1310114005626 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1310114005627 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1310114005628 potential frameshift: common BLAST hit: gi|471338466|ref|YP_007611179.1| aminopeptidase N 1310114005629 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1310114005630 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114005631 active site 1310114005632 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1310114005633 apolar tunnel; other site 1310114005634 heme binding site [chemical binding]; other site 1310114005635 dimerization interface [polypeptide binding]; other site 1310114005636 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1310114005637 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1310114005638 active site 1310114005639 catalytic site [active] 1310114005640 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1310114005641 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1310114005642 active site 1310114005643 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1310114005644 potential frameshift: common BLAST hit: gi|433627610|ref|YP_007261239.1| Putative NAD-dependent glutamate dehydrogenase Gdh (NAD-GDH) 1310114005645 potential frameshift: common BLAST hit: gi|433642675|ref|YP_007288434.1| Putative NAD-dependent glutamate dehydrogenase Gdh (NAD-GDH) 1310114005646 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1310114005647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310114005648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310114005649 ABC transporter; Region: ABC_tran_2; pfam12848 1310114005650 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310114005651 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1310114005652 dimer interface [polypeptide binding]; other site 1310114005653 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1310114005654 ssDNA binding site [nucleotide binding]; other site 1310114005655 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1310114005656 putative transposase OrfB; Reviewed; Region: PHA02517 1310114005657 HTH-like domain; Region: HTH_21; pfam13276 1310114005658 Integrase core domain; Region: rve; pfam00665 1310114005659 Integrase core domain; Region: rve_3; pfam13683 1310114005660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114005661 Transposase; Region: HTH_Tnp_1; cl17663 1310114005662 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1310114005663 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1310114005664 putative acyl-acceptor binding pocket; other site 1310114005665 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310114005666 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1310114005667 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114005668 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310114005669 putative acyl-acceptor binding pocket; other site 1310114005670 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114005671 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114005672 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114005673 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310114005674 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310114005675 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310114005676 potential frameshift: common BLAST hit: gi|471338483|ref|YP_007611196.1| enoyl-CoA hydratase 1310114005677 PE family; Region: PE; pfam00934 1310114005678 potential frameshift: common BLAST hit: gi|15842015|ref|NP_337052.1| LuxR family transcriptional regulator 1310114005679 potential frameshift: common BLAST hit: gi|385999268|ref|YP_005917567.1| LuxR family transcriptional regulator 1310114005680 PE family; Region: PE; pfam00934 1310114005681 TIGR00725 family protein; Region: TIGR00725 1310114005682 thymidylate synthase; Provisional; Region: thyA; PRK00956 1310114005683 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310114005684 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1310114005685 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310114005686 E3 interaction surface; other site 1310114005687 lipoyl attachment site [posttranslational modification]; other site 1310114005688 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310114005689 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1310114005690 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1310114005691 alpha subunit interface [polypeptide binding]; other site 1310114005692 TPP binding site [chemical binding]; other site 1310114005693 heterodimer interface [polypeptide binding]; other site 1310114005694 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1310114005695 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1310114005696 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1310114005697 tetramer interface [polypeptide binding]; other site 1310114005698 TPP-binding site [chemical binding]; other site 1310114005699 heterodimer interface [polypeptide binding]; other site 1310114005700 phosphorylation loop region [posttranslational modification] 1310114005701 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1310114005702 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1310114005703 putative active site [active] 1310114005704 putative catalytic site [active] 1310114005705 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114005706 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114005707 active site 1310114005708 potential frameshift: common BLAST hit: gi|449064574|ref|YP_007431657.1| acetyl-coenzyme A carboxylase subunit alpha 1310114005709 potential frameshift: common BLAST hit: gi|449064574|ref|YP_007431657.1| acetyl-coenzyme A carboxylase subunit alpha 1310114005710 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310114005711 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310114005712 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310114005713 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1310114005714 potential frameshift: common BLAST hit: gi|471338504|ref|YP_007611217.1| succinyl-CoA:3-ketoacid-coenzyme A transferasesubunit alpha 1310114005715 AMP-binding domain protein; Validated; Region: PRK08315 1310114005716 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114005717 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1310114005718 acyl-activating enzyme (AAE) consensus motif; other site 1310114005719 acyl-activating enzyme (AAE) consensus motif; other site 1310114005720 putative AMP binding site [chemical binding]; other site 1310114005721 putative active site [active] 1310114005722 putative CoA binding site [chemical binding]; other site 1310114005723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114005724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114005725 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1310114005726 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310114005727 classical (c) SDRs; Region: SDR_c; cd05233 1310114005728 NAD(P) binding site [chemical binding]; other site 1310114005729 active site 1310114005730 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1310114005731 potential frameshift: common BLAST hit: gi|397674414|ref|YP_006515949.1| AAA ATPase 1310114005732 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1310114005733 catalytic site [active] 1310114005734 putative active site [active] 1310114005735 putative substrate binding site [chemical binding]; other site 1310114005736 dimer interface [polypeptide binding]; other site 1310114005737 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114005738 MULE transposase domain; Region: MULE; pfam10551 1310114005739 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1310114005740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1310114005741 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1310114005742 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1310114005743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310114005744 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310114005745 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1310114005746 PE family; Region: PE; pfam00934 1310114005747 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1310114005748 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1310114005749 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310114005750 catalytic triad [active] 1310114005751 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1310114005752 potential frameshift: common BLAST hit: gi|433642722|ref|YP_007288481.1| Putative fatty acid synthase Fas (fatty acid synthetase) 1310114005753 potential frameshift: common BLAST hit: gi|433631637|ref|YP_007265265.1| Putative fatty acid synthase Fas (fatty acid synthetase) 1310114005754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114005755 active site 1310114005756 potential frameshift: common BLAST hit: gi|385995451|ref|YP_005913749.1| fatty acid synthase 1310114005757 potential frameshift: common BLAST hit: gi|385995451|ref|YP_005913749.1| fatty acid synthase 1310114005758 potential frameshift: common BLAST hit: gi|385995451|ref|YP_005913749.1| fatty acid synthase 1310114005759 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310114005760 active site 2 [active] 1310114005761 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1310114005762 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1310114005763 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1310114005764 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310114005765 phosphate binding site [ion binding]; other site 1310114005766 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1310114005767 potential frameshift: common BLAST hit: gi|433627658|ref|YP_007261287.1| Putative fatty acid synthase Fas (fatty acid synthetase) 1310114005768 potential frameshift: common BLAST hit: gi|433642723|ref|YP_007288482.1| Conserved exported protein of unknown function 1310114005769 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310114005770 putative active site [active] 1310114005771 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1310114005772 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1310114005773 Restriction endonuclease; Region: Mrr_cat; pfam04471 1310114005774 ERCC4 domain; Region: ERCC4; pfam02732 1310114005775 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310114005776 putative active site [active] 1310114005777 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1310114005778 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114005779 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114005780 catalytic residue [active] 1310114005781 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1310114005782 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1310114005783 potential frameshift: common BLAST hit: gi|471338538|ref|YP_007611251.1| elongation factor P 1310114005784 potential frameshift: common BLAST hit: gi|449064610|ref|YP_007431693.1| cytoplasmic peptidase PepQ 1310114005785 potential frameshift: common BLAST hit: gi|449064611|ref|YP_007431694.1| transmembrane protein 1310114005786 potential frameshift: common BLAST hit: gi|471338541|ref|YP_007611254.1| 3-dehydroquinate dehydratase 1310114005787 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1310114005788 active site 1310114005789 dimer interface [polypeptide binding]; other site 1310114005790 metal binding site [ion binding]; metal-binding site 1310114005791 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1310114005792 shikimate kinase; Reviewed; Region: aroK; PRK00131 1310114005793 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 1310114005794 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 1310114005795 potential frameshift: common BLAST hit: gi|449064616|ref|YP_007431699.1| putative alanine rich protein 1310114005796 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310114005797 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310114005798 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310114005799 putative active site [active] 1310114005800 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114005801 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1310114005802 oligomeric interface; other site 1310114005803 putative active site [active] 1310114005804 homodimer interface [polypeptide binding]; other site 1310114005805 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1310114005806 putative active site [active] 1310114005807 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114005808 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1310114005809 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1310114005810 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 1310114005811 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1310114005812 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1310114005813 dimerization interface [polypeptide binding]; other site 1310114005814 potential frameshift: common BLAST hit: gi|471338561|ref|YP_007611274.1| alanyl-tRNA synthetase 1310114005815 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1310114005816 recombination factor protein RarA; Reviewed; Region: PRK13342 1310114005817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114005818 Walker A motif; other site 1310114005819 ATP binding site [chemical binding]; other site 1310114005820 Walker B motif; other site 1310114005821 arginine finger; other site 1310114005822 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1310114005823 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1310114005824 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1310114005825 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310114005826 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310114005827 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310114005828 Walker A/P-loop; other site 1310114005829 ATP binding site [chemical binding]; other site 1310114005830 Q-loop/lid; other site 1310114005831 ABC transporter signature motif; other site 1310114005832 Walker B; other site 1310114005833 D-loop; other site 1310114005834 H-loop/switch region; other site 1310114005835 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310114005836 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310114005837 ligand binding site [chemical binding]; other site 1310114005838 flexible hinge region; other site 1310114005839 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310114005840 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310114005841 ligand binding site [chemical binding]; other site 1310114005842 flexible hinge region; other site 1310114005843 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1310114005844 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1310114005845 active site 1310114005846 nucleophile elbow; other site 1310114005847 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1310114005848 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1310114005849 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1310114005850 potential frameshift: common BLAST hit: gi|148662405|ref|YP_001283928.1| transglutaminase 1310114005851 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1310114005852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1310114005853 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1310114005854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1310114005855 Predicted membrane protein [Function unknown]; Region: COG4129 1310114005856 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1310114005857 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310114005858 active site 1310114005859 motif 3; other site 1310114005860 potential frameshift: common BLAST hit: gi|449064649|ref|YP_007431732.1| Aspartyl-tRNA synthetase 1310114005861 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1310114005862 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1310114005863 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1310114005864 putative hydrophobic ligand binding site [chemical binding]; other site 1310114005865 protein interface [polypeptide binding]; other site 1310114005866 gate; other site 1310114005867 Predicted metalloprotease [General function prediction only]; Region: COG2321 1310114005868 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1310114005869 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1310114005870 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1310114005871 active site 1310114005872 metal binding site [ion binding]; metal-binding site 1310114005873 haloalkane dehalogenase; Provisional; Region: PRK03592 1310114005874 potential frameshift: common BLAST hit: gi|471338587|ref|YP_007611300.1| histidyl-tRNA synthetase 1310114005875 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310114005876 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1310114005877 active site 1310114005878 potential frameshift: common BLAST hit: gi|253798336|ref|YP_003031337.1| GTP pyrophosphokinase 1310114005879 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1310114005880 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1310114005881 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310114005882 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1310114005883 Protein export membrane protein; Region: SecD_SecF; pfam02355 1310114005884 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1310114005885 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1310114005886 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1310114005887 potential frameshift: common BLAST hit: gi|471338596|ref|YP_007611309.1| 4-aminobutyrate aminotransferase 1310114005888 potential frameshift: common BLAST hit: gi|433642790|ref|YP_007288549.1| Putative fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) 1310114005889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114005890 acyl-activating enzyme (AAE) consensus motif; other site 1310114005891 AMP binding site [chemical binding]; other site 1310114005892 active site 1310114005893 CoA binding site [chemical binding]; other site 1310114005894 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1310114005895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114005896 NAD(P) binding site [chemical binding]; other site 1310114005897 active site 1310114005898 PE family; Region: PE; pfam00934 1310114005899 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1310114005900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114005901 Walker A motif; other site 1310114005902 ATP binding site [chemical binding]; other site 1310114005903 Walker B motif; other site 1310114005904 arginine finger; other site 1310114005905 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1310114005906 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1310114005907 RuvA N terminal domain; Region: RuvA_N; pfam01330 1310114005908 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1310114005909 active site 1310114005910 putative DNA-binding cleft [nucleotide binding]; other site 1310114005911 dimer interface [polypeptide binding]; other site 1310114005912 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1310114005913 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1310114005914 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310114005915 putative active site [active] 1310114005916 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1310114005917 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1310114005918 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1310114005919 potential frameshift: common BLAST hit: gi|471338608|ref|YP_007611321.1| spermidine synthase 1310114005920 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1310114005921 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310114005922 hypothetical protein; Validated; Region: PRK00110 1310114005923 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 1310114005924 conserved cys residue [active] 1310114005925 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1310114005926 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1310114005927 active site 1310114005928 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1310114005929 catalytic triad [active] 1310114005930 dimer interface [polypeptide binding]; other site 1310114005931 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1310114005932 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1310114005933 active site 1310114005934 multimer interface [polypeptide binding]; other site 1310114005935 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1310114005936 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1310114005937 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1310114005938 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114005939 PPE family; Region: PPE; pfam00823 1310114005940 PPE family; Region: PPE; pfam00823 1310114005941 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114005942 PE-PPE domain; Region: PE-PPE; pfam08237 1310114005943 potential frameshift: common BLAST hit: gi|471338618|ref|YP_007611331.1| alpha-mannosyltransferase 1310114005944 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1310114005945 putative acyl-acceptor binding pocket; other site 1310114005946 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1310114005947 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1310114005948 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1310114005949 nucleotide binding site/active site [active] 1310114005950 HIT family signature motif; other site 1310114005951 catalytic residue [active] 1310114005952 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1310114005953 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1310114005954 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1310114005955 active site 1310114005956 dimer interface [polypeptide binding]; other site 1310114005957 motif 1; other site 1310114005958 motif 2; other site 1310114005959 motif 3; other site 1310114005960 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1310114005961 anticodon binding site; other site 1310114005962 PE family; Region: PE; pfam00934 1310114005963 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 1310114005964 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1310114005965 Predicted transcriptional regulator [Transcription]; Region: COG2345 1310114005966 Helix-turn-helix domain; Region: HTH_20; pfam12840 1310114005967 potential frameshift: common BLAST hit: gi|449064703|ref|YP_007431786.1| methyltransferase/methylase 1310114005968 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114005969 Ligand Binding Site [chemical binding]; other site 1310114005970 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114005971 Ligand Binding Site [chemical binding]; other site 1310114005972 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114005973 Ligand Binding Site [chemical binding]; other site 1310114005974 Universal stress protein family; Region: Usp; pfam00582 1310114005975 Ligand Binding Site [chemical binding]; other site 1310114005976 FOG: CBS domain [General function prediction only]; Region: COG0517 1310114005977 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1310114005978 peptide chain release factor 1; Provisional; Region: PRK04011 1310114005979 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 1310114005980 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1310114005981 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1310114005982 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1310114005983 Hemerythrin-like domain; Region: Hr-like; cd12108 1310114005984 Fe binding site [ion binding]; other site 1310114005985 PE family; Region: PE; pfam00934 1310114005986 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1310114005987 P-loop motif; other site 1310114005988 ATP binding site [chemical binding]; other site 1310114005989 Chloramphenicol (Cm) binding site [chemical binding]; other site 1310114005990 catalytic residue [active] 1310114005991 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1310114005992 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1310114005993 hypothetical protein; Provisional; Region: PRK02237 1310114005994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114005995 putative DNA binding site [nucleotide binding]; other site 1310114005996 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1310114005997 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310114005998 putative metal binding site [ion binding]; other site 1310114005999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114006000 dimerization interface [polypeptide binding]; other site 1310114006001 putative DNA binding site [nucleotide binding]; other site 1310114006002 putative Zn2+ binding site [ion binding]; other site 1310114006003 potential frameshift: common BLAST hit: gi|471338651|ref|YP_007611364.1| arsenic-transport integral membrane protein 1310114006004 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1310114006005 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1310114006006 potential frameshift: common BLAST hit: gi|471338655|ref|YP_007611368.1| integrase 1310114006007 potential frameshift: common BLAST hit: gi|471338655|ref|YP_007611368.1| integrase 1310114006008 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1310114006009 ParB-like nuclease domain; Region: ParBc; cl02129 1310114006010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114006011 Transposase; Region: HTH_Tnp_1; cl17663 1310114006012 putative transposase OrfB; Reviewed; Region: PHA02517 1310114006013 HTH-like domain; Region: HTH_21; pfam13276 1310114006014 Integrase core domain; Region: rve; pfam00665 1310114006015 Integrase core domain; Region: rve_3; pfam13683 1310114006016 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1310114006017 Phage capsid family; Region: Phage_capsid; pfam05065 1310114006018 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1310114006019 Phage terminase, small subunit; Region: Terminase_4; cl01525 1310114006020 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1310114006021 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1310114006022 DNA binding domain, excisionase family; Region: excise; TIGR01764 1310114006023 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1310114006024 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1310114006025 active site 1310114006026 catalytic residues [active] 1310114006027 DNA binding site [nucleotide binding] 1310114006028 Int/Topo IB signature motif; other site 1310114006029 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114006030 MULE transposase domain; Region: MULE; pfam10551 1310114006031 potential frameshift: common BLAST hit: gi|471338673|ref|YP_007611386.1| ATP-dependent protease ATP-binding subunit 1310114006032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1310114006033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310114006034 Coenzyme A binding pocket [chemical binding]; other site 1310114006035 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1310114006036 hypothetical protein; Provisional; Region: PRK14059 1310114006037 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1310114006038 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114006039 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310114006040 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1310114006041 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1310114006042 SelR domain; Region: SelR; pfam01641 1310114006043 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1310114006044 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1310114006045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310114006046 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1310114006047 potential frameshift: common BLAST hit: gi|471338684|ref|YP_007611397.1| uroporphyrinogen decarboxylase 1310114006048 potential protein location (hypothetical protein) that overlaps protein (uroporphyrinogen decarboxylase) 1310114006049 potential frameshift: common BLAST hit: gi|449064746|ref|YP_007431829.1| enoyl-CoA hydratase 1310114006050 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1310114006051 potential frameshift: common BLAST hit: gi|397674590|ref|YP_006516125.1| ribonuclease D 1310114006052 potential frameshift: common BLAST hit: gi|471338688|ref|YP_007611401.1| 1-deoxy-D-xylulose-5-phosphate synthase 1310114006053 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1310114006054 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1310114006055 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1310114006056 transmembrane helices; other site 1310114006057 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1310114006058 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1310114006059 transmembrane helices; other site 1310114006060 potential frameshift: common BLAST hit: gi|449064755|ref|YP_007431838.1| putative antibiotic-transport ATP-binding protein ABC transporter 1310114006061 TRAM domain; Region: TRAM; cl01282 1310114006062 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1310114006063 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1310114006064 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1310114006065 TrkA-N domain; Region: TrkA_N; pfam02254 1310114006066 TrkA-C domain; Region: TrkA_C; pfam02080 1310114006067 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1310114006068 TrkA-N domain; Region: TrkA_N; pfam02254 1310114006069 TrkA-C domain; Region: TrkA_C; pfam02080 1310114006070 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1310114006071 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1310114006072 generic binding surface II; other site 1310114006073 ssDNA binding site; other site 1310114006074 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1310114006075 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1310114006076 trimer interface [polypeptide binding]; other site 1310114006077 active site 1310114006078 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1310114006079 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1310114006080 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310114006081 potential frameshift: common BLAST hit: gi|449064768|ref|YP_007431851.1| Inositol-1-monophosphatase 1310114006082 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1310114006083 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310114006084 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1310114006085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114006086 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1310114006087 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310114006088 DNA binding residues [nucleotide binding] 1310114006089 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1310114006090 homotrimer interaction site [polypeptide binding]; other site 1310114006091 putative active site [active] 1310114006092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1310114006093 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1310114006094 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1310114006095 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1310114006096 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1310114006097 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1310114006098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114006099 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1310114006100 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310114006101 DNA binding residues [nucleotide binding] 1310114006102 potential frameshift: common BLAST hit: gi|471338717|ref|YP_007611430.1| iron-dependent repressor and activator 1310114006103 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1310114006104 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1310114006105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310114006106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114006107 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310114006108 PAC2 family; Region: PAC2; pfam09754 1310114006109 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114006110 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1310114006111 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1310114006112 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1310114006113 heme-binding site [chemical binding]; other site 1310114006114 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1310114006115 ATP cone domain; Region: ATP-cone; pfam03477 1310114006116 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1310114006117 LexA repressor; Validated; Region: PRK00215 1310114006118 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1310114006119 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1310114006120 Catalytic site [active] 1310114006121 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1310114006122 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1310114006123 LGFP repeat; Region: LGFP; pfam08310 1310114006124 LGFP repeat; Region: LGFP; pfam08310 1310114006125 LGFP repeat; Region: LGFP; pfam08310 1310114006126 LGFP repeat; Region: LGFP; pfam08310 1310114006127 LGFP repeat; Region: LGFP; pfam08310 1310114006128 Integral membrane protein TerC family; Region: TerC; cl10468 1310114006129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114006130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114006131 active site 1310114006132 GTPases [General function prediction only]; Region: HflX; COG2262 1310114006133 HflX GTPase family; Region: HflX; cd01878 1310114006134 G1 box; other site 1310114006135 GTP/Mg2+ binding site [chemical binding]; other site 1310114006136 Switch I region; other site 1310114006137 G2 box; other site 1310114006138 G3 box; other site 1310114006139 Switch II region; other site 1310114006140 G4 box; other site 1310114006141 G5 box; other site 1310114006142 GTPases [General function prediction only]; Region: HflX; COG2262 1310114006143 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1310114006144 potential frameshift: common BLAST hit: gi|449064793|ref|YP_007431876.1| diaminopimelate epimerase dapF 1310114006145 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 1310114006146 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1310114006147 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1310114006148 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1310114006149 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1310114006150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114006151 FeS/SAM binding site; other site 1310114006152 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1310114006153 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1310114006154 recA bacterial DNA recombination protein; Region: RecA; cl17211 1310114006155 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1310114006156 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1310114006157 protein-splicing catalytic site; other site 1310114006158 thioester formation/cholesterol transfer; other site 1310114006159 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1310114006160 recA bacterial DNA recombination protein; Region: RecA; cl17211 1310114006161 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1310114006162 Walker A motif; other site 1310114006163 ATP binding site [chemical binding]; other site 1310114006164 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1310114006165 potential frameshift: common BLAST hit: gi|471338745|ref|YP_007611458.1| UDP-glucosyltransferase 1310114006166 potential frameshift: common BLAST hit: gi|471338745|ref|YP_007611458.1| UDP-glucosyltransferase 1310114006167 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1310114006168 PE family; Region: PE; pfam00934 1310114006169 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1310114006170 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1310114006171 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1310114006172 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1310114006173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310114006174 non-specific DNA binding site [nucleotide binding]; other site 1310114006175 salt bridge; other site 1310114006176 sequence-specific DNA binding site [nucleotide binding]; other site 1310114006177 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1310114006178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310114006179 Coenzyme A binding pocket [chemical binding]; other site 1310114006180 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1310114006181 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310114006182 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1310114006183 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1310114006184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114006185 NAD(P) binding site [chemical binding]; other site 1310114006186 classical (c) SDRs; Region: SDR_c; cd05233 1310114006187 NAD(P) binding site [chemical binding]; other site 1310114006188 active site 1310114006189 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114006190 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114006191 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1310114006192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310114006193 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1310114006194 potential frameshift: common BLAST hit: gi|471338762|ref|YP_007611475.1| dihydrodipicolinate synthase 1310114006195 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1310114006196 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1310114006197 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1310114006198 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1310114006199 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1310114006200 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1310114006201 putative active site [active] 1310114006202 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1310114006203 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1310114006204 putative active site [active] 1310114006205 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1310114006206 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1310114006207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1310114006208 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1310114006209 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1310114006210 folate binding site [chemical binding]; other site 1310114006211 NADP+ binding site [chemical binding]; other site 1310114006212 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1310114006213 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1310114006214 dimerization interface [polypeptide binding]; other site 1310114006215 active site 1310114006216 Dienelactone hydrolase family; Region: DLH; pfam01738 1310114006217 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1310114006218 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1310114006219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114006220 classical (c) SDRs; Region: SDR_c; cd05233 1310114006221 NAD(P) binding site [chemical binding]; other site 1310114006222 active site 1310114006223 PE family; Region: PE; pfam00934 1310114006224 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114006225 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114006226 PPE family; Region: PPE; pfam00823 1310114006227 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1310114006228 potential frameshift: common BLAST hit: gi|471338782|ref|YP_007611495.1| transmembrane protein 1310114006229 potential frameshift: common BLAST hit: gi|385995669|ref|YP_005913967.1| dihydrodipicolinate reductase 1310114006230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1310114006231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310114006232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310114006233 Coenzyme A binding pocket [chemical binding]; other site 1310114006234 potential frameshift: common BLAST hit: gi|471338786|ref|YP_007611499.1| oxidoreductase 1310114006235 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1310114006236 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1310114006237 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310114006238 hydrophobic ligand binding site; other site 1310114006239 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1310114006240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114006241 putative DNA binding site [nucleotide binding]; other site 1310114006242 putative Zn2+ binding site [ion binding]; other site 1310114006243 AsnC family; Region: AsnC_trans_reg; pfam01037 1310114006244 potential frameshift: common BLAST hit: gi|471338790|ref|YP_007611503.1| secreted L-alanine dehydrogenase 1310114006245 potential frameshift: common BLAST hit: gi|471338790|ref|YP_007611503.1| secreted L-alanine dehydrogenase 1310114006246 potential frameshift: common BLAST hit: gi|471338791|ref|YP_007611504.1| alanine rich oxidoreductase 1310114006247 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1310114006248 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1310114006249 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1310114006250 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1310114006251 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1310114006252 oligomer interface [polypeptide binding]; other site 1310114006253 RNA binding site [nucleotide binding]; other site 1310114006254 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1310114006255 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1310114006256 RNase E interface [polypeptide binding]; other site 1310114006257 trimer interface [polypeptide binding]; other site 1310114006258 active site 1310114006259 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1310114006260 putative nucleic acid binding region [nucleotide binding]; other site 1310114006261 G-X-X-G motif; other site 1310114006262 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1310114006263 RNA binding site [nucleotide binding]; other site 1310114006264 domain interface; other site 1310114006265 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1310114006266 16S/18S rRNA binding site [nucleotide binding]; other site 1310114006267 S13e-L30e interaction site [polypeptide binding]; other site 1310114006268 25S rRNA binding site [nucleotide binding]; other site 1310114006269 potential frameshift: common BLAST hit: gi|471338796|ref|YP_007611509.1| bifunctional riboflavin kinase/FMNadenylyltransferase 1310114006270 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310114006271 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310114006272 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1310114006273 potential frameshift: common BLAST hit: gi|471338798|ref|YP_007611511.1| transcriptional repressor 1310114006274 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114006275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114006276 active site 1310114006277 lipid-transfer protein; Provisional; Region: PRK08256 1310114006278 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1310114006279 active site 1310114006280 potential frameshift: common BLAST hit: gi|471338801|ref|YP_007611514.1| transposase 1310114006281 potential frameshift: common BLAST hit: gi|471338802|ref|YP_007611515.1| resolvase 1310114006282 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1310114006283 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1310114006284 RNA binding site [nucleotide binding]; other site 1310114006285 active site 1310114006286 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1310114006287 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1310114006288 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1310114006289 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1310114006290 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1310114006291 active site 1310114006292 metal binding site [ion binding]; metal-binding site 1310114006293 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1310114006294 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310114006295 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1310114006296 Predicted acyl esterases [General function prediction only]; Region: COG2936 1310114006297 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1310114006298 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1310114006299 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1310114006300 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 1310114006301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1310114006302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310114006303 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310114006304 potential frameshift: common BLAST hit: gi|397674724|ref|YP_006516259.1| transposase 1310114006305 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1310114006306 putative transposase OrfB; Reviewed; Region: PHA02517 1310114006307 HTH-like domain; Region: HTH_21; pfam13276 1310114006308 Integrase core domain; Region: rve; pfam00665 1310114006309 Integrase core domain; Region: rve_3; pfam13683 1310114006310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114006311 Transposase; Region: HTH_Tnp_1; cl17663 1310114006312 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1310114006313 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1310114006314 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 1310114006315 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 1310114006316 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 1310114006317 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1310114006318 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1310114006319 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1310114006320 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1310114006321 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1310114006322 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1310114006323 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 1310114006324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1310114006325 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1310114006326 putative active site [active] 1310114006327 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310114006328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114006329 substrate binding site [chemical binding]; other site 1310114006330 oxyanion hole (OAH) forming residues; other site 1310114006331 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114006332 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310114006333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114006334 Walker B; other site 1310114006335 D-loop; other site 1310114006336 H-loop/switch region; other site 1310114006337 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1310114006338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114006339 Walker A/P-loop; other site 1310114006340 ATP binding site [chemical binding]; other site 1310114006341 Q-loop/lid; other site 1310114006342 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1310114006343 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1310114006344 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310114006345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114006346 dimer interface [polypeptide binding]; other site 1310114006347 conserved gate region; other site 1310114006348 putative PBP binding loops; other site 1310114006349 ABC-ATPase subunit interface; other site 1310114006350 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1310114006351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114006352 dimer interface [polypeptide binding]; other site 1310114006353 conserved gate region; other site 1310114006354 putative PBP binding loops; other site 1310114006355 ABC-ATPase subunit interface; other site 1310114006356 potential frameshift: common BLAST hit: gi|471338853|ref|YP_007611566.1| DNA-damage-inducible protein F 1310114006357 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1310114006358 DHH family; Region: DHH; pfam01368 1310114006359 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1310114006360 potential frameshift: common BLAST hit: gi|339632848|ref|YP_004724490.1| translation initiation factor 2 1310114006361 potential frameshift: common BLAST hit: gi|449064913|ref|YP_007431996.1| translation initiation factor IF-2 infB 1310114006362 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1310114006363 putative RNA binding cleft [nucleotide binding]; other site 1310114006364 potential frameshift: common BLAST hit: gi|471338859|ref|YP_007611572.1| transcription elongation factor 1310114006365 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1310114006366 Sm and related proteins; Region: Sm_like; cl00259 1310114006367 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1310114006368 putative oligomer interface [polypeptide binding]; other site 1310114006369 putative RNA binding site [nucleotide binding]; other site 1310114006370 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1310114006371 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1310114006372 dinuclear metal binding motif [ion binding]; other site 1310114006373 potential frameshift: common BLAST hit: gi|471338863|ref|YP_007611576.1| prolyl-tRNA synthetase 1310114006374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114006375 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310114006376 putative substrate translocation pore; other site 1310114006377 potential frameshift: common BLAST hit: gi|471338865|ref|YP_007611578.1| multifunctional uroporphyrinogen IIImethylase/precorrin-2 1310114006378 potential frameshift: common BLAST hit: gi|449064922|ref|YP_007432005.1| cobyrinic acid a,c-diamide synthase 1310114006379 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1310114006380 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1310114006381 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310114006382 potential frameshift: common BLAST hit: gi|471338868|ref|YP_007611581.1| magnesium chelatase 1310114006383 malate:quinone oxidoreductase; Validated; Region: PRK05257 1310114006384 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1310114006385 PE family; Region: PE; pfam00934 1310114006386 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1310114006387 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310114006388 mycothione reductase; Reviewed; Region: PRK07846 1310114006389 mycothione reductase; Reviewed; Region: PRK07846 1310114006390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310114006391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114006392 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310114006393 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1310114006394 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310114006395 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310114006396 short chain dehydrogenase; Provisional; Region: PRK06057 1310114006397 classical (c) SDRs; Region: SDR_c; cd05233 1310114006398 NAD(P) binding site [chemical binding]; other site 1310114006399 active site 1310114006400 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310114006401 potential frameshift: common BLAST hit: gi|471338878|ref|YP_007611591.1| aldehyde dehydrogenase 1310114006402 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1310114006403 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1310114006404 catalytic triad [active] 1310114006405 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1310114006406 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1310114006407 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310114006408 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1310114006409 active site 1310114006410 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310114006411 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1310114006412 putative active site [active] 1310114006413 potential frameshift: common BLAST hit: gi|471338884|ref|YP_007611597.1| penicillin-binding lipoprotein 1310114006414 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1310114006415 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1310114006416 potential frameshift: common BLAST hit: gi|433643058|ref|YP_007288817.1| Gcn5-related N-acetyltransferase 1310114006417 potential frameshift: common BLAST hit: gi|449064945|ref|YP_007432028.1| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1310114006418 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1310114006419 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1310114006420 active site 1310114006421 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1310114006422 protein binding site [polypeptide binding]; other site 1310114006423 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1310114006424 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1310114006425 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1310114006426 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1310114006427 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114006428 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310114006429 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1310114006430 Fasciclin domain; Region: Fasciclin; pfam02469 1310114006431 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310114006432 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1310114006433 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1310114006434 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1310114006435 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310114006436 catalytic residues [active] 1310114006437 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1310114006438 Fasciclin domain; Region: Fasciclin; pfam02469 1310114006439 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1310114006440 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1310114006441 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310114006442 catalytic residues [active] 1310114006443 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1310114006444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114006445 FeS/SAM binding site; other site 1310114006446 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1310114006447 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1310114006448 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1310114006449 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1310114006450 hinge region; other site 1310114006451 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1310114006452 putative nucleotide binding site [chemical binding]; other site 1310114006453 uridine monophosphate binding site [chemical binding]; other site 1310114006454 homohexameric interface [polypeptide binding]; other site 1310114006455 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114006456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114006457 DNA binding site [nucleotide binding] 1310114006458 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310114006459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310114006460 Probable transposase; Region: OrfB_IS605; pfam01385 1310114006461 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310114006462 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1310114006463 catalytic residues [active] 1310114006464 catalytic nucleophile [active] 1310114006465 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310114006466 MarR family; Region: MarR; pfam01047 1310114006467 amidase; Provisional; Region: PRK07869 1310114006468 Amidase; Region: Amidase; pfam01425 1310114006469 potential frameshift: common BLAST hit: gi|471338911|ref|YP_007611624.1| elongation factor Ts 1310114006470 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1310114006471 rRNA interaction site [nucleotide binding]; other site 1310114006472 S8 interaction site; other site 1310114006473 putative laminin-1 binding site; other site 1310114006474 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114006475 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114006476 potential frameshift: common BLAST hit: gi|471338918|ref|YP_007611631.1| site-specific tyrosine recombinase 1310114006477 potential frameshift: common BLAST hit: gi|471338919|ref|YP_007611632.1| mycobactin utilization protein 1310114006478 potential frameshift: common BLAST hit: gi|397674814|ref|YP_006516349.1| DNA protecting protein DprA 1310114006479 potential frameshift: common BLAST hit: gi|397674815|ref|YP_006516350.1| Mg chelatase-like protein 1310114006480 potential frameshift: common BLAST hit: gi|471338923|ref|YP_007611636.1| formate dehydrogenase accessory protein 1310114006481 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1310114006482 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1310114006483 putative molybdopterin cofactor binding site [chemical binding]; other site 1310114006484 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1310114006485 putative molybdopterin cofactor binding site; other site 1310114006486 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1310114006487 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1310114006488 RNA/DNA hybrid binding site [nucleotide binding]; other site 1310114006489 active site 1310114006490 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1310114006491 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1310114006492 Catalytic site [active] 1310114006493 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1310114006494 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1310114006495 potential frameshift: common BLAST hit: gi|471338929|ref|YP_007611642.1| alanine rich lipoprotein 1310114006496 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1310114006497 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1310114006498 RimM N-terminal domain; Region: RimM; pfam01782 1310114006499 hypothetical protein; Provisional; Region: PRK02821 1310114006500 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1310114006501 G-X-X-G motif; other site 1310114006502 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1310114006503 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1310114006504 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1310114006505 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1310114006506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114006507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114006508 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1310114006509 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1310114006510 active site 1310114006511 putative substrate binding pocket [chemical binding]; other site 1310114006512 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310114006513 potential frameshift: common BLAST hit: gi|471338938|ref|YP_007611651.1| transmembrane serine/threonine-protein kinase I 1310114006514 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310114006515 active site 1310114006516 signal recognition particle protein; Provisional; Region: PRK10867 1310114006517 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1310114006518 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310114006519 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1310114006520 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310114006521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310114006522 ATP binding site [chemical binding]; other site 1310114006523 putative Mg++ binding site [ion binding]; other site 1310114006524 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310114006525 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1310114006526 metal binding triad; other site 1310114006527 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1310114006528 PII uridylyl-transferase; Provisional; Region: PRK03381 1310114006529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310114006530 Zn2+ binding site [ion binding]; other site 1310114006531 Mg2+ binding site [ion binding]; other site 1310114006532 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1310114006533 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1310114006534 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1310114006535 potential frameshift: common BLAST hit: gi|471338944|ref|YP_007611657.1| ammonium transporter 1310114006536 potential frameshift: common BLAST hit: gi|433643112|ref|YP_007288871.1| Putative ammonium-transport integral membrane protein Amt 1310114006537 potential frameshift: common BLAST hit: gi|471338945|ref|YP_007611658.1| cell division protein 1310114006538 potential frameshift: common BLAST hit: gi|433628040|ref|YP_007261669.1| Putative cell division protein FtsY (SRP receptor) (signal 1310114006539 potential frameshift: common BLAST hit: gi|433643114|ref|YP_007288873.1| Chromosome partition protein Smc 1310114006540 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1310114006541 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1310114006542 Acylphosphatase; Region: Acylphosphatase; cl00551 1310114006543 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1310114006544 AAA domain; Region: AAA_23; pfam13476 1310114006545 Walker A/P-loop; other site 1310114006546 ATP binding site [chemical binding]; other site 1310114006547 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1310114006548 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1310114006549 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1310114006550 DNA binding site [nucleotide binding] 1310114006551 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310114006552 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1310114006553 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1310114006554 catalytic residue [active] 1310114006555 H2TH interface [polypeptide binding]; other site 1310114006556 putative catalytic residues [active] 1310114006557 ribonuclease III; Reviewed; Region: rnc; PRK00102 1310114006558 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1310114006559 dimerization interface [polypeptide binding]; other site 1310114006560 active site 1310114006561 metal binding site [ion binding]; metal-binding site 1310114006562 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1310114006563 dsRNA binding site [nucleotide binding]; other site 1310114006564 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1310114006565 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1310114006566 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1310114006567 acyl-CoA synthetase; Validated; Region: PRK05850 1310114006568 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114006569 acyl-activating enzyme (AAE) consensus motif; other site 1310114006570 active site 1310114006571 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310114006572 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310114006573 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114006574 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310114006575 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310114006576 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1310114006577 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310114006578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114006579 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1310114006580 KR domain; Region: KR; pfam08659 1310114006581 active site 1310114006582 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310114006583 potential frameshift: common BLAST hit: gi|397674851|ref|YP_006516386.1| phenolpthiocerol synthesis polyketide synthase PpsB 1310114006584 potential frameshift: common BLAST hit: gi|383308675|ref|YP_005361486.1| phenolpthiocerol synthesis type-I polyketide synthase ppsB 1310114006585 potential frameshift: common BLAST hit: gi|471338957|ref|YP_007611670.1| phenolpthiocerol synthesis type-I polyketidesynthase 1310114006586 potential frameshift: common BLAST hit: gi|392431456|ref|YP_006472500.1| phenolpthiocerol synthesis type-I polyketide synthase ppsc 1310114006587 potential frameshift: common BLAST hit: gi|449065013|ref|YP_007432096.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC 1310114006588 potential frameshift: common BLAST hit: gi|449065013|ref|YP_007432096.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC 1310114006589 potential frameshift: common BLAST hit: gi|449065013|ref|YP_007432096.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC 1310114006590 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114006591 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310114006592 active site 1310114006593 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310114006594 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310114006595 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310114006596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114006597 potential frameshift: common BLAST hit: gi|471338959|ref|YP_007611672.1| phenolpthiocerol synthesis type-I polyketidesynthase 1310114006598 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310114006599 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114006600 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114006601 active site 1310114006602 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1310114006603 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310114006604 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310114006605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310114006606 Condensation domain; Region: Condensation; pfam00668 1310114006607 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1310114006608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114006609 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1310114006610 Walker A/P-loop; other site 1310114006611 ATP binding site [chemical binding]; other site 1310114006612 Q-loop/lid; other site 1310114006613 ABC transporter signature motif; other site 1310114006614 Walker B; other site 1310114006615 D-loop; other site 1310114006616 H-loop/switch region; other site 1310114006617 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1310114006618 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1310114006619 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1310114006620 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1310114006621 acyltransferase PapA5; Provisional; Region: PRK09294 1310114006622 potential frameshift: common BLAST hit: gi|471338965|ref|YP_007611678.1| multifunctional mycocerosic acid synthasemembrane-associated MAS 1310114006623 potential frameshift: common BLAST hit: gi|471338965|ref|YP_007611678.1| multifunctional mycocerosic acid synthasemembrane-associated MAS 1310114006624 potential frameshift: common BLAST hit: gi|471338965|ref|YP_007611678.1| multifunctional mycocerosic acid synthasemembrane-associated MAS 1310114006625 acyl-CoA synthetase; Validated; Region: PRK05850 1310114006626 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114006627 acyl-activating enzyme (AAE) consensus motif; other site 1310114006628 active site 1310114006629 potential frameshift: common BLAST hit: gi|449065022|ref|YP_007432105.1| transmembrane transporter mmpL7 1310114006630 potential frameshift: common BLAST hit: gi|471338969|ref|YP_007611682.1| IS1533 transposase 1310114006631 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1310114006632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114006633 ATP binding site [chemical binding]; other site 1310114006634 Walker A motif; other site 1310114006635 Walker B motif; other site 1310114006636 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1310114006637 potential frameshift: common BLAST hit: gi|383308689|ref|YP_005361500.1| polyketide synthase pks1 1310114006638 potential frameshift: common BLAST hit: gi|385995831|ref|YP_005914129.1| polyketide synthase PKS1 1310114006639 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310114006640 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310114006641 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1310114006642 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310114006643 active site 1310114006644 Erythronolide synthase docking; Region: Docking; pfam08990 1310114006645 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310114006646 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310114006647 acyl-CoA synthetase; Validated; Region: PRK06060 1310114006648 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1310114006649 dimer interface [polypeptide binding]; other site 1310114006650 acyl-activating enzyme (AAE) consensus motif; other site 1310114006651 putative active site [active] 1310114006652 putative AMP binding site [chemical binding]; other site 1310114006653 putative CoA binding site [chemical binding]; other site 1310114006654 chemical substrate binding site [chemical binding]; other site 1310114006655 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310114006656 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1310114006657 acyl-CoA synthetase; Validated; Region: PRK05850 1310114006658 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114006659 acyl-activating enzyme (AAE) consensus motif; other site 1310114006660 active site 1310114006661 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1310114006662 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310114006663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114006664 S-adenosylmethionine binding site [chemical binding]; other site 1310114006665 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1310114006666 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1310114006667 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310114006668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114006669 S-adenosylmethionine binding site [chemical binding]; other site 1310114006670 potential frameshift: common BLAST hit: gi|397674873|ref|YP_006516408.1| FkbM family methyltransferase 1310114006671 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1310114006672 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1310114006673 metal-binding site 1310114006674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114006675 potential frameshift: common BLAST hit: gi|471338985|ref|YP_007611698.1| glycosyl transferase 1310114006676 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1310114006677 potential frameshift: common BLAST hit: gi|449065045|ref|YP_007432128.1| glycosyl transferase 1310114006678 potential frameshift: common BLAST hit: gi|471338989|ref|YP_007611702.1| integral membrane protein 1310114006679 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1310114006680 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1310114006681 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1310114006682 putative active site [active] 1310114006683 putative substrate binding site [chemical binding]; other site 1310114006684 putative cosubstrate binding site; other site 1310114006685 catalytic site [active] 1310114006686 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1310114006687 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1310114006688 active site 1310114006689 (T/H)XGH motif; other site 1310114006690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310114006691 pyruvate carboxylase; Reviewed; Region: PRK12999 1310114006692 potential frameshift: common BLAST hit: gi|471338994|ref|YP_007611707.1| pyruvate carboxylase 1310114006693 potential frameshift: common BLAST hit: gi|471338994|ref|YP_007611707.1| pyruvate carboxylase 1310114006694 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1310114006695 putative active site [active] 1310114006696 redox center [active] 1310114006697 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1310114006698 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1310114006699 catalytic residues [active] 1310114006700 potential frameshift: common BLAST hit: gi|449065054|ref|YP_007432137.1| lipase/esterase lipN 1310114006701 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1310114006702 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310114006703 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310114006704 active site 1310114006705 catalytic tetrad [active] 1310114006706 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1310114006707 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1310114006708 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1310114006709 generic binding surface II; other site 1310114006710 ssDNA binding site; other site 1310114006711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310114006712 ATP binding site [chemical binding]; other site 1310114006713 putative Mg++ binding site [ion binding]; other site 1310114006714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310114006715 nucleotide binding region [chemical binding]; other site 1310114006716 ATP-binding site [chemical binding]; other site 1310114006717 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1310114006718 DAK2 domain; Region: Dak2; cl03685 1310114006719 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1310114006720 DAK2 domain; Region: Dak2; cl03685 1310114006721 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1310114006722 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1310114006723 ligand binding site [chemical binding]; other site 1310114006724 active site 1310114006725 UGI interface [polypeptide binding]; other site 1310114006726 catalytic site [active] 1310114006727 potential frameshift: common BLAST hit: gi|471339006|ref|YP_007611719.1| thiamine monophosphate kinase 1310114006728 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310114006729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310114006730 Probable transposase; Region: OrfB_IS605; pfam01385 1310114006731 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310114006732 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1310114006733 catalytic residues [active] 1310114006734 catalytic nucleophile [active] 1310114006735 potential frameshift: common BLAST hit: gi|449065065|ref|YP_007432148.1| secreted protein 1310114006736 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1310114006737 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1310114006738 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1310114006739 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1310114006740 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1310114006741 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1310114006742 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1310114006743 polyphosphate kinase; Provisional; Region: PRK05443 1310114006744 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1310114006745 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1310114006746 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1310114006747 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1310114006748 putative active site [active] 1310114006749 catalytic site [active] 1310114006750 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1310114006751 PLD-like domain; Region: PLDc_2; pfam13091 1310114006752 putative active site [active] 1310114006753 catalytic site [active] 1310114006754 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1310114006755 active site 1310114006756 Ap6A binding site [chemical binding]; other site 1310114006757 nudix motif; other site 1310114006758 metal binding site [ion binding]; metal-binding site 1310114006759 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310114006760 catalytic core [active] 1310114006761 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1310114006762 IHF - DNA interface [nucleotide binding]; other site 1310114006763 IHF dimer interface [polypeptide binding]; other site 1310114006764 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1310114006765 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1310114006766 substrate binding site [chemical binding]; other site 1310114006767 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1310114006768 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1310114006769 substrate binding site [chemical binding]; other site 1310114006770 ligand binding site [chemical binding]; other site 1310114006771 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1310114006772 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310114006773 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310114006774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310114006775 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1310114006776 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1310114006777 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1310114006778 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114006779 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1310114006780 active site 1310114006781 HIGH motif; other site 1310114006782 nucleotide binding site [chemical binding]; other site 1310114006783 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1310114006784 active site 1310114006785 KMSKS motif; other site 1310114006786 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1310114006787 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1310114006788 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1310114006789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114006790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310114006791 putative substrate translocation pore; other site 1310114006792 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1310114006793 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1310114006794 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1310114006795 dimerization interface [polypeptide binding]; other site 1310114006796 NAD binding site [chemical binding]; other site 1310114006797 catalytic site [active] 1310114006798 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1310114006799 putative L-serine binding site [chemical binding]; other site 1310114006800 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1310114006801 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1310114006802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1310114006803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1310114006804 phosphorylation site [posttranslational modification] 1310114006805 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1310114006806 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1310114006807 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1310114006808 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1310114006809 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1310114006810 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1310114006811 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1310114006812 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1310114006813 putative valine binding site [chemical binding]; other site 1310114006814 dimer interface [polypeptide binding]; other site 1310114006815 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1310114006816 potential frameshift: common BLAST hit: gi|471339033|ref|YP_007611746.1| acetolactate synthase 1 catalytic subunit 1310114006817 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1310114006818 Predicted membrane protein [Function unknown]; Region: COG2259 1310114006819 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1310114006820 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1310114006821 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1310114006822 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1310114006823 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1310114006824 GatB domain; Region: GatB_Yqey; smart00845 1310114006825 6-phosphofructokinase; Provisional; Region: PRK03202 1310114006826 active site 1310114006827 ADP/pyrophosphate binding site [chemical binding]; other site 1310114006828 allosteric effector site; other site 1310114006829 dimerization interface [polypeptide binding]; other site 1310114006830 fructose-1,6-bisphosphate binding site; other site 1310114006831 potential frameshift: common BLAST hit: gi|433628133|ref|YP_007261762.1| Putative glutamyl-tRNA(Gln) amidotransferase (subunit A) GatA 1310114006832 potential frameshift: common BLAST hit: gi|471339041|ref|YP_007611754.1| aspartyl/glutamyl-tRNA amidotransferase subunitA 1310114006833 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1310114006834 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1310114006835 potential frameshift: common BLAST hit: gi|471339044|ref|YP_007611757.1| NAD-dependent DNA ligase 1310114006836 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310114006837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310114006838 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114006839 PPE family; Region: PPE; pfam00823 1310114006840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310114006841 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114006842 PPE family; Region: PPE; pfam00823 1310114006843 PE family; Region: PE; pfam00934 1310114006844 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114006845 MULE transposase domain; Region: MULE; pfam10551 1310114006846 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1310114006847 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1310114006848 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1310114006849 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1310114006850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114006851 catalytic residue [active] 1310114006852 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114006853 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310114006854 putative acyl-acceptor binding pocket; other site 1310114006855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1310114006856 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1310114006857 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1310114006858 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1310114006859 Ligand Binding Site [chemical binding]; other site 1310114006860 potential frameshift: common BLAST hit: gi|471339056|ref|YP_007611769.1| electron transfer flavoprotein subunit beta 1310114006861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114006862 S-adenosylmethionine binding site [chemical binding]; other site 1310114006863 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1310114006864 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1310114006865 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1310114006866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310114006867 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310114006868 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1310114006869 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1310114006870 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1310114006871 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1310114006872 trimer interface [polypeptide binding]; other site 1310114006873 active site 1310114006874 substrate binding site [chemical binding]; other site 1310114006875 CoA binding site [chemical binding]; other site 1310114006876 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1310114006877 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1310114006878 active site 1310114006879 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1310114006880 potential frameshift: common BLAST hit: gi|397674963|ref|YP_006516498.1| methyltransferase 1310114006881 potential frameshift: common BLAST hit: gi|471339067|ref|YP_007611780.1| enoyl-CoA hydratase 1310114006882 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1310114006883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114006884 Walker A/P-loop; other site 1310114006885 ATP binding site [chemical binding]; other site 1310114006886 Q-loop/lid; other site 1310114006887 ABC transporter signature motif; other site 1310114006888 Walker B; other site 1310114006889 D-loop; other site 1310114006890 H-loop/switch region; other site 1310114006891 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1310114006892 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1310114006893 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310114006894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310114006895 motif II; other site 1310114006896 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1310114006897 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1310114006898 D-pathway; other site 1310114006899 Putative ubiquinol binding site [chemical binding]; other site 1310114006900 Low-spin heme (heme b) binding site [chemical binding]; other site 1310114006901 Putative water exit pathway; other site 1310114006902 Binuclear center (heme o3/CuB) [ion binding]; other site 1310114006903 K-pathway; other site 1310114006904 Putative proton exit pathway; other site 1310114006905 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1310114006906 potential frameshift: common BLAST hit: gi|449065132|ref|YP_007432215.1| FEIII-dicitrate-binding periplasmic lipoprotein 1310114006907 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1310114006908 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1310114006909 putative NAD(P) binding site [chemical binding]; other site 1310114006910 putative substrate binding site [chemical binding]; other site 1310114006911 catalytic Zn binding site [ion binding]; other site 1310114006912 structural Zn binding site [ion binding]; other site 1310114006913 dimer interface [polypeptide binding]; other site 1310114006914 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1310114006915 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1310114006916 dimer interface [polypeptide binding]; other site 1310114006917 putative radical transfer pathway; other site 1310114006918 diiron center [ion binding]; other site 1310114006919 tyrosyl radical; other site 1310114006920 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114006921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310114006922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114006923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114006924 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1310114006925 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1310114006926 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1310114006927 active site 1310114006928 dimer interface [polypeptide binding]; other site 1310114006929 catalytic residues [active] 1310114006930 effector binding site; other site 1310114006931 R2 peptide binding site; other site 1310114006932 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1310114006933 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1310114006934 catalytic residues [active] 1310114006935 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1310114006936 DNA binding site [nucleotide binding] 1310114006937 short chain dehydrogenase; Provisional; Region: PRK07832 1310114006938 classical (c) SDRs; Region: SDR_c; cd05233 1310114006939 NAD(P) binding site [chemical binding]; other site 1310114006940 active site 1310114006941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114006942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114006943 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114006944 Cytochrome P450; Region: p450; cl12078 1310114006945 potential frameshift: common BLAST hit: gi|449065150|ref|YP_007432233.1| GntR family transcriptional regulator 1310114006946 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114006947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114006948 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114006949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114006950 active site 1310114006951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114006952 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1310114006953 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1310114006954 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 1310114006955 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1310114006956 active site 1310114006957 DNA binding site [nucleotide binding] 1310114006958 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1310114006959 DNA binding site [nucleotide binding] 1310114006960 potential frameshift: common BLAST hit: gi|385995944|ref|YP_005914242.1| carbon starvation protein A cstA 1310114006961 Predicted membrane protein [Function unknown]; Region: COG2259 1310114006962 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1310114006963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1310114006964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114006965 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114006966 potential frameshift: common BLAST hit: gi|471339099|ref|YP_007611812.1| phosphoglucomutase 1310114006967 camphor resistance protein CrcB; Provisional; Region: PRK14216 1310114006968 camphor resistance protein CrcB; Provisional; Region: PRK14228 1310114006969 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114006970 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114006971 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1310114006972 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1310114006973 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1310114006974 putative hydrophobic ligand binding site [chemical binding]; other site 1310114006975 protein interface [polypeptide binding]; other site 1310114006976 gate; other site 1310114006977 potential frameshift: common BLAST hit: gi|397675003|ref|YP_006516538.1| hydrolase 1310114006978 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1310114006979 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114006980 potential frameshift: common BLAST hit: gi|449065171|ref|YP_007432254.1| serine/threonine-protein kinase transcriptional regulatory protein 1310114006981 potential frameshift: common BLAST hit: gi|433628221|ref|YP_007261850.1| Putative serine/threonine-protein kinase transcriptional regulatory 1310114006982 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1310114006983 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1310114006984 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310114006985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310114006986 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114006987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310114006988 potential frameshift: common BLAST hit: gi|397675010|ref|YP_006516545.1| esterase/lipase 1310114006989 short chain dehydrogenase; Provisional; Region: PRK07832 1310114006990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114006991 NAD(P) binding site [chemical binding]; other site 1310114006992 active site 1310114006993 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1310114006994 catalytic Zn binding site [ion binding]; other site 1310114006995 substrate binding site [chemical binding]; other site 1310114006996 structural Zn binding site [ion binding]; other site 1310114006997 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114006998 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114006999 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114007000 potential frameshift: common BLAST hit: gi|397675014|ref|YP_006516549.1| acyltransferase, WS/DGAT/MGAT 1310114007001 potential frameshift: common BLAST hit: gi|471339120|ref|YP_007611833.1| chain-fatty-acid-CoA ligase 1310114007002 potential frameshift: common BLAST hit: gi|471339120|ref|YP_007611833.1| chain-fatty-acid-CoA ligase 1310114007003 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1310114007004 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1310114007005 Patatin-like phospholipase; Region: Patatin; pfam01734 1310114007006 Protein of unknown function (DUF808); Region: DUF808; cl01002 1310114007007 Protein of unknown function (DUF808); Region: DUF808; cl01002 1310114007008 potential frameshift: common BLAST hit: gi|397675020|ref|YP_006516555.1| oxidoreductase 1310114007009 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114007010 active site 1310114007011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114007012 Predicted transcriptional regulators [Transcription]; Region: COG1733 1310114007013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114007014 dimerization interface [polypeptide binding]; other site 1310114007015 putative DNA binding site [nucleotide binding]; other site 1310114007016 putative Zn2+ binding site [ion binding]; other site 1310114007017 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1310114007018 PE family; Region: PE; pfam00934 1310114007019 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310114007020 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1310114007021 De-etiolated protein 1 Det1; Region: Det1; pfam09737 1310114007022 PemK-like protein; Region: PemK; pfam02452 1310114007023 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1310114007024 SmpB-tmRNA interface; other site 1310114007025 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1310114007026 FtsX-like permease family; Region: FtsX; pfam02687 1310114007027 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1310114007028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310114007029 Walker A/P-loop; other site 1310114007030 ATP binding site [chemical binding]; other site 1310114007031 Q-loop/lid; other site 1310114007032 ABC transporter signature motif; other site 1310114007033 Walker B; other site 1310114007034 D-loop; other site 1310114007035 H-loop/switch region; other site 1310114007036 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1310114007037 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1310114007038 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1310114007039 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1310114007040 RF-1 domain; Region: RF-1; pfam00472 1310114007041 potential frameshift: common BLAST hit: gi|471339141|ref|YP_007611854.1| NADPH:adrenodoxin oxidoreductase 1310114007042 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310114007043 FAD binding domain; Region: FAD_binding_4; pfam01565 1310114007044 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1310114007045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114007046 FeS/SAM binding site; other site 1310114007047 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1310114007048 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1310114007049 aromatic arch; other site 1310114007050 DCoH dimer interaction site [polypeptide binding]; other site 1310114007051 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1310114007052 DCoH tetramer interaction site [polypeptide binding]; other site 1310114007053 substrate binding site [chemical binding]; other site 1310114007054 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1310114007055 trimer interface [polypeptide binding]; other site 1310114007056 dimer interface [polypeptide binding]; other site 1310114007057 putative active site [active] 1310114007058 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1310114007059 MoaE interaction surface [polypeptide binding]; other site 1310114007060 MoeB interaction surface [polypeptide binding]; other site 1310114007061 thiocarboxylated glycine; other site 1310114007062 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1310114007063 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1310114007064 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1310114007065 nucleoside/Zn binding site; other site 1310114007066 dimer interface [polypeptide binding]; other site 1310114007067 catalytic motif [active] 1310114007068 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114007069 MULE transposase domain; Region: MULE; pfam10551 1310114007070 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1310114007071 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1310114007072 ATP binding site [chemical binding]; other site 1310114007073 substrate interface [chemical binding]; other site 1310114007074 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310114007075 active site residue [active] 1310114007076 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310114007077 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310114007078 active site residue [active] 1310114007079 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310114007080 active site residue [active] 1310114007081 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1310114007082 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1310114007083 MoaE homodimer interface [polypeptide binding]; other site 1310114007084 MoaD interaction [polypeptide binding]; other site 1310114007085 active site residues [active] 1310114007086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114007087 S-adenosylmethionine binding site [chemical binding]; other site 1310114007088 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114007089 Cytochrome P450; Region: p450; cl12078 1310114007090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1310114007091 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1310114007092 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1310114007093 DNA binding site [nucleotide binding] 1310114007094 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007095 PPE family; Region: PPE; pfam00823 1310114007096 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310114007097 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1310114007098 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114007099 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114007100 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310114007101 dimer interface [polypeptide binding]; other site 1310114007102 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1310114007103 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1310114007104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1310114007105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310114007106 Histidine kinase; Region: HisKA_3; pfam07730 1310114007107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114007108 ATP binding site [chemical binding]; other site 1310114007109 Mg2+ binding site [ion binding]; other site 1310114007110 G-X-G motif; other site 1310114007111 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310114007112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114007113 active site 1310114007114 phosphorylation site [posttranslational modification] 1310114007115 intermolecular recognition site; other site 1310114007116 dimerization interface [polypeptide binding]; other site 1310114007117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310114007118 DNA binding residues [nucleotide binding] 1310114007119 dimerization interface [polypeptide binding]; other site 1310114007120 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310114007121 Ligand Binding Site [chemical binding]; other site 1310114007122 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007123 PPE family; Region: PPE; pfam00823 1310114007124 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007125 PPE family; Region: PPE; pfam00823 1310114007126 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114007127 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1310114007128 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1310114007129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114007130 FeS/SAM binding site; other site 1310114007131 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114007132 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114007133 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114007134 active site 1310114007135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114007136 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114007137 active site 1310114007138 potential frameshift: common BLAST hit: gi|471339180|ref|YP_007611893.1| NADPH quinone oxidoreductase 1310114007139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114007140 active site 1310114007141 phosphorylation site [posttranslational modification] 1310114007142 intermolecular recognition site; other site 1310114007143 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007144 PPE family; Region: PPE; pfam00823 1310114007145 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1310114007146 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1310114007147 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1310114007148 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1310114007149 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1310114007150 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1310114007151 potential frameshift: common BLAST hit: gi|449065244|ref|YP_007432327.1| NADH dehydrogenase I chain F 1310114007152 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310114007153 catalytic loop [active] 1310114007154 iron binding site [ion binding]; other site 1310114007155 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1310114007156 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114007157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310114007158 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1310114007159 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1310114007160 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1310114007161 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1310114007162 4Fe-4S binding domain; Region: Fer4; pfam00037 1310114007163 4Fe-4S binding domain; Region: Fer4; pfam00037 1310114007164 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1310114007165 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1310114007166 potential frameshift: common BLAST hit: gi|471339196|ref|YP_007611909.1| NADH dehydrogenase subunit L 1310114007167 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1310114007168 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310114007169 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1310114007170 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310114007171 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007172 PPE family; Region: PPE; pfam00823 1310114007173 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1310114007174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114007175 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1310114007176 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1310114007177 [2Fe-2S] cluster binding site [ion binding]; other site 1310114007178 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1310114007179 putative alpha subunit interface [polypeptide binding]; other site 1310114007180 putative active site [active] 1310114007181 putative substrate binding site [chemical binding]; other site 1310114007182 Fe binding site [ion binding]; other site 1310114007183 potential frameshift: common BLAST hit: gi|433636243|ref|YP_007269870.1| Conserved exported protein of unknown function 1310114007184 MoxR-like ATPases [General function prediction only]; Region: COG0714 1310114007185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114007186 Walker A motif; other site 1310114007187 ATP binding site [chemical binding]; other site 1310114007188 Walker B motif; other site 1310114007189 arginine finger; other site 1310114007190 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1310114007191 potential frameshift: common BLAST hit: gi|471339207|ref|YP_007611920.1| TetR family transcriptional regulator 1310114007192 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1310114007193 putative active site [active] 1310114007194 putative substrate binding site [chemical binding]; other site 1310114007195 ATP binding site [chemical binding]; other site 1310114007196 Phosphotransferase enzyme family; Region: APH; pfam01636 1310114007197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310114007198 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1310114007199 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114007200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310114007201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114007202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114007203 short chain dehydrogenase; Validated; Region: PRK08264 1310114007204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114007205 NAD(P) binding site [chemical binding]; other site 1310114007206 active site 1310114007207 potential frameshift: common BLAST hit: gi|471339215|ref|YP_007611928.1| amidase 1310114007208 potential frameshift: common BLAST hit: gi|433628306|ref|YP_007261935.1| Putative epoxide hydrolase MesT (epoxide hydratase) (arene-oxide 1310114007209 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310114007210 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310114007211 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310114007212 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310114007213 putative active site [active] 1310114007214 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310114007215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1310114007216 potential frameshift: common BLAST hit: gi|449065281|ref|YP_007432364.1| transcriptional regulatory protein 1310114007217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114007218 Transposase; Region: HTH_Tnp_1; cl17663 1310114007219 putative transposase OrfB; Reviewed; Region: PHA02517 1310114007220 HTH-like domain; Region: HTH_21; pfam13276 1310114007221 Integrase core domain; Region: rve; pfam00665 1310114007222 Integrase core domain; Region: rve_3; pfam13683 1310114007223 RES domain; Region: RES; pfam08808 1310114007224 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1310114007225 Helix-turn-helix domain; Region: HTH_38; pfam13936 1310114007226 Integrase core domain; Region: rve; pfam00665 1310114007227 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114007228 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1310114007229 hypothetical protein; Validated; Region: PRK00068 1310114007230 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1310114007231 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1310114007232 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1310114007233 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1310114007234 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1310114007235 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1310114007236 ABC1 family; Region: ABC1; pfam03109 1310114007237 Phosphotransferase enzyme family; Region: APH; pfam01636 1310114007238 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1310114007239 active site 1310114007240 ATP binding site [chemical binding]; other site 1310114007241 Transcription factor WhiB; Region: Whib; pfam02467 1310114007242 potential frameshift: common BLAST hit: gi|471339245|ref|YP_007611958.1| ATP-dependent DNA helicase 1310114007243 potential frameshift: common BLAST hit: gi|449065298|ref|YP_007432381.1| ATP-dependent DNA helicase II uvrD2 1310114007244 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1310114007245 catalytic residues [active] 1310114007246 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1310114007247 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1310114007248 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1310114007249 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1310114007250 putative NADH binding site [chemical binding]; other site 1310114007251 putative active site [active] 1310114007252 nudix motif; other site 1310114007253 putative metal binding site [ion binding]; other site 1310114007254 potential frameshift: common BLAST hit: gi|397675135|ref|YP_006516670.1| NAD+ diphosphatase 1310114007255 potential frameshift: common BLAST hit: gi|385992449|ref|YP_005910747.1| ATP-dependent DNA helicase 1310114007256 potential frameshift: common BLAST hit: gi|471339249|ref|YP_007611962.1| ATP-dependent DNA helicase 1310114007257 potential frameshift: common BLAST hit: gi|471339250|ref|YP_007611963.1| ATP-dependent DNA helicase 1310114007258 potential frameshift: common BLAST hit: gi|449065303|ref|YP_007432386.1| ATP-dependent DNA helicase 1310114007259 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310114007260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310114007261 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1310114007262 active site 1310114007263 DNA binding site [nucleotide binding] 1310114007264 TIGR02569 family protein; Region: TIGR02569_actnb 1310114007265 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1310114007266 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1310114007267 ATP binding site [chemical binding]; other site 1310114007268 substrate interface [chemical binding]; other site 1310114007269 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310114007270 active site residue [active] 1310114007271 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1310114007272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114007273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114007274 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1310114007275 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1310114007276 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1310114007277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1310114007278 putative Mg++ binding site [ion binding]; other site 1310114007279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310114007280 nucleotide binding region [chemical binding]; other site 1310114007281 ATP-binding site [chemical binding]; other site 1310114007282 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1310114007283 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310114007284 P-loop; other site 1310114007285 Magnesium ion binding site [ion binding]; other site 1310114007286 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310114007287 Magnesium ion binding site [ion binding]; other site 1310114007288 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310114007289 catalytic core [active] 1310114007290 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1310114007291 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1310114007292 Transcription factor WhiB; Region: Whib; pfam02467 1310114007293 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1310114007294 PAS domain S-box; Region: sensory_box; TIGR00229 1310114007295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1310114007296 Histidine kinase; Region: HisKA_2; pfam07568 1310114007297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114007298 ATP binding site [chemical binding]; other site 1310114007299 Mg2+ binding site [ion binding]; other site 1310114007300 G-X-G motif; other site 1310114007301 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310114007302 carboxyltransferase (CT) interaction site; other site 1310114007303 biotinylation site [posttranslational modification]; other site 1310114007304 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1310114007305 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1310114007306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114007307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310114007308 DNA binding residues [nucleotide binding] 1310114007309 short chain dehydrogenase; Provisional; Region: PRK08278 1310114007310 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1310114007311 NAD(P) binding site [chemical binding]; other site 1310114007312 homodimer interface [polypeptide binding]; other site 1310114007313 active site 1310114007314 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1310114007315 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1310114007316 putative deacylase active site [active] 1310114007317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1310114007318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310114007319 Coenzyme A binding pocket [chemical binding]; other site 1310114007320 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1310114007321 Phosphotransferase enzyme family; Region: APH; pfam01636 1310114007322 putative active site [active] 1310114007323 putative substrate binding site [chemical binding]; other site 1310114007324 ATP binding site [chemical binding]; other site 1310114007325 potential frameshift: common BLAST hit: gi|433643421|ref|YP_007289180.1| 3-phosphoshikimate 1-carboxyvinyltransferase AroA 1310114007326 Predicted GTPases [General function prediction only]; Region: COG1162 1310114007327 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1310114007328 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1310114007329 GTP/Mg2+ binding site [chemical binding]; other site 1310114007330 G4 box; other site 1310114007331 G5 box; other site 1310114007332 G1 box; other site 1310114007333 Switch I region; other site 1310114007334 G2 box; other site 1310114007335 G3 box; other site 1310114007336 Switch II region; other site 1310114007337 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1310114007338 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1310114007339 putative di-iron ligands [ion binding]; other site 1310114007340 potential frameshift: common BLAST hit: gi|471339281|ref|YP_007611994.1| oxidoreductase 1310114007341 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1310114007342 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114007343 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114007344 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1310114007345 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1310114007346 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1310114007347 TrkA-C domain; Region: TrkA_C; pfam02080 1310114007348 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1310114007349 potential frameshift: common BLAST hit: gi|471339290|ref|YP_007612003.1| transmembrane transport protein 1310114007350 potential frameshift: common BLAST hit: gi|471339290|ref|YP_007612003.1| transmembrane transport protein 1310114007351 potential frameshift: common BLAST hit: gi|471339290|ref|YP_007612003.1| transmembrane transport protein 1310114007352 potential frameshift: common BLAST hit: gi|449065344|ref|YP_007432427.1| preprotein translocase subunit SecA 1310114007353 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1310114007354 30S subunit binding site; other site 1310114007355 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1310114007356 lipoprotein LpqB; Provisional; Region: PRK13616 1310114007357 Sporulation and spore germination; Region: Germane; pfam10646 1310114007358 potential frameshift: common BLAST hit: gi|385996120|ref|YP_005914418.1| two component system sensor transduction histidine kinase mtrB 1310114007359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114007360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114007361 active site 1310114007362 phosphorylation site [posttranslational modification] 1310114007363 intermolecular recognition site; other site 1310114007364 dimerization interface [polypeptide binding]; other site 1310114007365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114007366 DNA binding site [nucleotide binding] 1310114007367 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1310114007368 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1310114007369 TMP-binding site; other site 1310114007370 ATP-binding site [chemical binding]; other site 1310114007371 potential frameshift: common BLAST hit: gi|471339300|ref|YP_007612013.1| S-adenosyl-L-homocysteine hydrolase 1310114007372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114007373 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1310114007374 Rubredoxin [Energy production and conversion]; Region: COG1773 1310114007375 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1310114007376 iron binding site [ion binding]; other site 1310114007377 Rubredoxin [Energy production and conversion]; Region: COG1773 1310114007378 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1310114007379 iron binding site [ion binding]; other site 1310114007380 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1310114007381 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1310114007382 Di-iron ligands [ion binding]; other site 1310114007383 amino acid transporter; Region: 2A0306; TIGR00909 1310114007384 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1310114007385 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1310114007386 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1310114007387 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1310114007388 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1310114007389 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1310114007390 active site 1310114007391 substrate binding site [chemical binding]; other site 1310114007392 metal binding site [ion binding]; metal-binding site 1310114007393 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1310114007394 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1310114007395 Transcription factor WhiB; Region: Whib; pfam02467 1310114007396 potential frameshift: common BLAST hit: gi|471339313|ref|YP_007612026.1| LPPG:FO 2-phospho-L-lactate transferase 1310114007397 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1310114007398 potential frameshift: common BLAST hit: gi|471339314|ref|YP_007612027.1| F420-0-gamma-glutamyl ligase 1310114007399 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1310114007400 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1310114007401 potential frameshift: common BLAST hit: gi|471339318|ref|YP_007612031.1| D-alpha-D-mannose-1-phosphatguanylyltransferase 1310114007402 potential frameshift: common BLAST hit: gi|471339319|ref|YP_007612032.1| dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenolA-3-L-rhamnosyl 1310114007403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114007404 NAD(P) binding site [chemical binding]; other site 1310114007405 active site 1310114007406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114007407 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1310114007408 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310114007409 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1310114007410 potential frameshift: common BLAST hit: gi|471339324|ref|YP_007612037.1| metal cation transporter P-type ATPase 1310114007411 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310114007412 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310114007413 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1310114007414 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1310114007415 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1310114007416 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310114007417 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1310114007418 active site clefts [active] 1310114007419 zinc binding site [ion binding]; other site 1310114007420 dimer interface [polypeptide binding]; other site 1310114007421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114007422 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1310114007423 FAD binding site [chemical binding]; other site 1310114007424 homotetramer interface [polypeptide binding]; other site 1310114007425 substrate binding pocket [chemical binding]; other site 1310114007426 catalytic base [active] 1310114007427 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1310114007428 potential frameshift: common BLAST hit: gi|449065381|ref|YP_007432464.1| phosphoribosylaminoimidazole carboxylase ATPase subunit purK 1310114007429 potential frameshift: common BLAST hit: gi|449065381|ref|YP_007432464.1| phosphoribosylaminoimidazole carboxylase ATPase subunit purK 1310114007430 Predicted membrane protein [Function unknown]; Region: COG2246 1310114007431 GtrA-like protein; Region: GtrA; pfam04138 1310114007432 Bacterial PH domain; Region: DUF304; pfam03703 1310114007433 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1310114007434 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1310114007435 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1310114007436 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310114007437 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310114007438 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310114007439 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1310114007440 Maf-like protein; Region: Maf; pfam02545 1310114007441 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1310114007442 active site 1310114007443 dimer interface [polypeptide binding]; other site 1310114007444 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310114007445 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310114007446 active site residue [active] 1310114007447 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310114007448 active site residue [active] 1310114007449 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310114007450 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310114007451 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310114007452 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1310114007453 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310114007454 carboxyltransferase (CT) interaction site; other site 1310114007455 biotinylation site [posttranslational modification]; other site 1310114007456 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1310114007457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114007458 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1310114007459 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1310114007460 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1310114007461 L-lysine aminotransferase; Provisional; Region: PRK08297 1310114007462 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310114007463 inhibitor-cofactor binding pocket; inhibition site 1310114007464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114007465 catalytic residue [active] 1310114007466 putative DNA binding site [nucleotide binding]; other site 1310114007467 dimerization interface [polypeptide binding]; other site 1310114007468 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1310114007469 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1310114007470 putative Zn2+ binding site [ion binding]; other site 1310114007471 AsnC family; Region: AsnC_trans_reg; pfam01037 1310114007472 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1310114007473 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310114007474 potential frameshift: common BLAST hit: gi|433643489|ref|YP_007289248.1| Putative piperideine-6-carboxilic acid dehydrogenase Pcd 1310114007475 potential frameshift: common BLAST hit: gi|385996165|ref|YP_005914463.1| piperideine-6-carboxylic acid dehydrogenase 1310114007476 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1310114007477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114007478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114007479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310114007480 putative Mg++ binding site [ion binding]; other site 1310114007481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310114007482 nucleotide binding region [chemical binding]; other site 1310114007483 ATP-binding site [chemical binding]; other site 1310114007484 DEAD/H associated; Region: DEAD_assoc; pfam08494 1310114007485 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1310114007486 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1310114007487 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1310114007488 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1310114007489 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1310114007490 putative DNA binding site [nucleotide binding]; other site 1310114007491 catalytic residue [active] 1310114007492 putative H2TH interface [polypeptide binding]; other site 1310114007493 putative catalytic residues [active] 1310114007494 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310114007495 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1310114007496 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310114007497 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1310114007498 Sulfatase; Region: Sulfatase; pfam00884 1310114007499 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1310114007500 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1310114007501 active site 1310114007502 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1310114007503 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1310114007504 PhoU domain; Region: PhoU; pfam01895 1310114007505 PhoU domain; Region: PhoU; pfam01895 1310114007506 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1310114007507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114007508 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310114007509 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1310114007510 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1310114007511 putative active site pocket [active] 1310114007512 dimerization interface [polypeptide binding]; other site 1310114007513 putative catalytic residue [active] 1310114007514 potential frameshift: common BLAST hit: gi|433628447|ref|YP_007262076.1| Putative N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino 1310114007515 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1310114007516 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1310114007517 metal binding site [ion binding]; metal-binding site 1310114007518 potential frameshift: common BLAST hit: gi|471339361|ref|YP_007612074.1| purine nucleoside phosphorylase 1310114007519 potential frameshift: common BLAST hit: gi|471339362|ref|YP_007612075.1| phosphomannomutase 1310114007520 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310114007521 active site 1310114007522 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1310114007523 potential frameshift: common BLAST hit: gi|385996185|ref|YP_005914483.1| alpha/beta fold family hydrolase 1310114007524 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1310114007525 adenosine deaminase; Provisional; Region: PRK09358 1310114007526 active site 1310114007527 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1310114007528 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1310114007529 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1310114007530 potential frameshift: common BLAST hit: gi|449065422|ref|YP_007432505.1| cytidine deaminase cdd 1310114007531 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1310114007532 putative Iron-sulfur protein interface [polypeptide binding]; other site 1310114007533 putative proximal heme binding site [chemical binding]; other site 1310114007534 putative SdhD-like interface [polypeptide binding]; other site 1310114007535 putative distal heme binding site [chemical binding]; other site 1310114007536 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1310114007537 putative Iron-sulfur protein interface [polypeptide binding]; other site 1310114007538 putative proximal heme binding site [chemical binding]; other site 1310114007539 putative SdhC-like subunit interface [polypeptide binding]; other site 1310114007540 putative distal heme binding site [chemical binding]; other site 1310114007541 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1310114007542 L-aspartate oxidase; Provisional; Region: PRK06175 1310114007543 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1310114007544 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1310114007545 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1310114007546 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310114007547 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1310114007548 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1310114007549 MoaE interaction surface [polypeptide binding]; other site 1310114007550 MoeB interaction surface [polypeptide binding]; other site 1310114007551 thiocarboxylated glycine; other site 1310114007552 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1310114007553 MoaE homodimer interface [polypeptide binding]; other site 1310114007554 MoaD interaction [polypeptide binding]; other site 1310114007555 active site residues [active] 1310114007556 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1310114007557 trimer interface [polypeptide binding]; other site 1310114007558 dimer interface [polypeptide binding]; other site 1310114007559 putative active site [active] 1310114007560 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 1310114007561 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310114007562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310114007563 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310114007564 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310114007565 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310114007566 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1310114007567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114007568 potential frameshift: common BLAST hit: gi|449065439|ref|YP_007432522.1| aminotransferase 1310114007569 potential frameshift: common BLAST hit: gi|449065440|ref|YP_007432523.1| penicillin-binding protein DacB1 1310114007570 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1310114007571 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310114007572 active site 1310114007573 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1310114007574 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310114007575 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114007576 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1310114007577 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1310114007578 DNA binding residues [nucleotide binding] 1310114007579 dimer interface [polypeptide binding]; other site 1310114007580 metal binding site [ion binding]; metal-binding site 1310114007581 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1310114007582 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1310114007583 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1310114007584 active site 1310114007585 HIGH motif; other site 1310114007586 dimer interface [polypeptide binding]; other site 1310114007587 KMSKS motif; other site 1310114007588 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310114007589 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1310114007590 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1310114007591 isocitrate dehydrogenase; Validated; Region: PRK08299 1310114007592 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1310114007593 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1310114007594 homodimer interface [polypeptide binding]; other site 1310114007595 substrate-cofactor binding pocket; other site 1310114007596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114007597 catalytic residue [active] 1310114007598 potential frameshift: common BLAST hit: gi|471339397|ref|YP_007612110.1| homoserine O-acetyltransferase 1310114007599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114007600 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1310114007601 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007602 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007603 PPE family; Region: PPE; pfam00823 1310114007604 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007605 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007606 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007607 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007608 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007609 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007610 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007611 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007612 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007613 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007614 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007615 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007616 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007617 PE family; Region: PE; pfam00934 1310114007618 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1310114007619 potential frameshift: common BLAST hit: gi|148663209|ref|YP_001284732.1| PPE family protein 1310114007620 potential frameshift: common BLAST hit: gi|471339403|ref|YP_007612116.1| PPE family protein 1310114007621 PPE family; Region: PPE; pfam00823 1310114007622 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007623 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007624 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007625 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007626 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1310114007627 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310114007628 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310114007629 potential frameshift: common BLAST hit: gi|392433836|ref|YP_006474880.1| PPE family protein 1310114007630 potential frameshift: common BLAST hit: gi|148663212|ref|YP_001284735.1| PPE family protein 1310114007631 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007632 PPE family; Region: PPE; pfam00823 1310114007633 Berberine and berberine like; Region: BBE; pfam08031 1310114007634 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310114007635 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1310114007636 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1310114007637 potential frameshift: common BLAST hit: gi|433628500|ref|YP_007262129.1| Putative bifunctional protein FolD: methylenetetrahydrofolate 1310114007638 potential frameshift: common BLAST hit: gi|471339415|ref|YP_007612128.1| bifunctional methylenetetrahydrofolatedehydrogenase/ 1310114007639 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1310114007640 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1310114007641 potential frameshift: common BLAST hit: gi|449065474|ref|YP_007432557.1| oxidoreductase 1310114007642 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1310114007643 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1310114007644 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1310114007645 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1310114007646 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1310114007647 G1 box; other site 1310114007648 GTP/Mg2+ binding site [chemical binding]; other site 1310114007649 G2 box; other site 1310114007650 Switch I region; other site 1310114007651 G3 box; other site 1310114007652 Switch II region; other site 1310114007653 G4 box; other site 1310114007654 G5 box; other site 1310114007655 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1310114007656 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1310114007657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310114007658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310114007659 ATP binding site [chemical binding]; other site 1310114007660 Mg2+ binding site [ion binding]; other site 1310114007661 G-X-G motif; other site 1310114007662 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1310114007663 PE family; Region: PE; pfam00934 1310114007664 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1310114007665 FMN binding site [chemical binding]; other site 1310114007666 dimer interface [polypeptide binding]; other site 1310114007667 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1310114007668 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1310114007669 generic binding surface II; other site 1310114007670 generic binding surface I; other site 1310114007671 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1310114007672 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1310114007673 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1310114007674 PHP Thumb interface [polypeptide binding]; other site 1310114007675 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114007676 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1310114007677 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1310114007678 PE family; Region: PE; pfam00934 1310114007679 potential frameshift: common BLAST hit: gi|449065488|ref|YP_007432571.1| enoyl-CoA hydratase 1310114007680 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1310114007681 Amidase; Region: Amidase; pfam01425 1310114007682 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1310114007683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310114007684 motif II; other site 1310114007685 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1310114007686 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1310114007687 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1310114007688 TPP-binding site [chemical binding]; other site 1310114007689 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1310114007690 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1310114007691 PYR/PP interface [polypeptide binding]; other site 1310114007692 dimer interface [polypeptide binding]; other site 1310114007693 TPP binding site [chemical binding]; other site 1310114007694 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1310114007695 putative transposase OrfB; Reviewed; Region: PHA02517 1310114007696 HTH-like domain; Region: HTH_21; pfam13276 1310114007697 Integrase core domain; Region: rve; pfam00665 1310114007698 Integrase core domain; Region: rve_3; pfam13683 1310114007699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310114007700 Transposase; Region: HTH_Tnp_1; cl17663 1310114007701 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1310114007702 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1310114007703 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310114007704 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310114007705 substrate binding pocket [chemical binding]; other site 1310114007706 chain length determination region; other site 1310114007707 substrate-Mg2+ binding site; other site 1310114007708 catalytic residues [active] 1310114007709 aspartate-rich region 1; other site 1310114007710 active site lid residues [active] 1310114007711 aspartate-rich region 2; other site 1310114007712 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1310114007713 putative active site [active] 1310114007714 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310114007715 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310114007716 Transposase domain (DUF772); Region: DUF772; pfam05598 1310114007717 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1310114007718 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1310114007719 PE family; Region: PE; pfam00934 1310114007720 enoyl-CoA hydratase; Region: PLN02864 1310114007721 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310114007722 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310114007723 active site 2 [active] 1310114007724 active site 1 [active] 1310114007725 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310114007726 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1310114007727 putative NAD(P) binding site [chemical binding]; other site 1310114007728 active site 1310114007729 putative substrate binding site [chemical binding]; other site 1310114007730 classical (c) SDRs; Region: SDR_c; cd05233 1310114007731 NAD(P) binding site [chemical binding]; other site 1310114007732 active site 1310114007733 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114007734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114007735 S-adenosylmethionine binding site [chemical binding]; other site 1310114007736 potential frameshift: common BLAST hit: gi|471339449|ref|YP_007612162.1| nucleoside hydrolase 1310114007737 Y-family of DNA polymerases; Region: PolY; cl12025 1310114007738 potential frameshift: common BLAST hit: gi|449065509|ref|YP_007432592.1| GMP synthase 1310114007739 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1310114007740 active site lid residues [active] 1310114007741 substrate binding pocket [chemical binding]; other site 1310114007742 catalytic residues [active] 1310114007743 substrate-Mg2+ binding site; other site 1310114007744 aspartate-rich region 1; other site 1310114007745 aspartate-rich region 2; other site 1310114007746 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310114007747 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310114007748 substrate binding pocket [chemical binding]; other site 1310114007749 chain length determination region; other site 1310114007750 substrate-Mg2+ binding site; other site 1310114007751 catalytic residues [active] 1310114007752 aspartate-rich region 1; other site 1310114007753 active site lid residues [active] 1310114007754 aspartate-rich region 2; other site 1310114007755 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114007756 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114007757 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1310114007758 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1310114007759 potential frameshift: common BLAST hit: gi|397675351|ref|YP_006516886.1| kojibiose phosphorylase 1310114007760 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1310114007761 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114007762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114007763 catalytic residue [active] 1310114007764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1310114007765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1310114007766 hypothetical protein; Provisional; Region: PRK07579 1310114007767 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1310114007768 active site 1310114007769 cosubstrate binding site; other site 1310114007770 substrate binding site [chemical binding]; other site 1310114007771 catalytic site [active] 1310114007772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114007773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114007774 potential frameshift: common BLAST hit: gi|471339464|ref|YP_007612177.1| dioxygenase 1310114007775 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1310114007776 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1310114007777 putative active site [active] 1310114007778 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1310114007779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310114007780 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1310114007781 potential frameshift: common BLAST hit: gi|339633415|ref|YP_004725057.1| IMP dehydrogenase 1310114007782 potential frameshift: common BLAST hit: gi|471339468|ref|YP_007612181.1| inositol-5-monophosphate dehydrogenase 1310114007783 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310114007784 phosphate binding site [ion binding]; other site 1310114007785 potential frameshift: common BLAST hit: gi|449065524|ref|YP_007432607.1| inosine 5'-monophosphate dehydrogenase 1310114007786 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1310114007787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310114007788 Transcription factor WhiB; Region: Whib; pfam02467 1310114007789 potential frameshift: common BLAST hit: gi|471339475|ref|YP_007612188.1| chaperonin 1310114007790 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1310114007791 oligomerisation interface [polypeptide binding]; other site 1310114007792 mobile loop; other site 1310114007793 roof hairpin; other site 1310114007794 UGMP family protein; Validated; Region: PRK09604 1310114007795 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1310114007796 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1310114007797 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1310114007798 Coenzyme A binding pocket [chemical binding]; other site 1310114007799 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1310114007800 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1310114007801 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1310114007802 alanine racemase; Reviewed; Region: alr; PRK00053 1310114007803 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1310114007804 active site 1310114007805 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310114007806 dimer interface [polypeptide binding]; other site 1310114007807 substrate binding site [chemical binding]; other site 1310114007808 catalytic residues [active] 1310114007809 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007810 PPE family; Region: PPE; pfam00823 1310114007811 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007812 PPE family; Region: PPE; pfam00823 1310114007813 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1310114007814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1310114007815 potential frameshift: common BLAST hit: gi|471339486|ref|YP_007612199.1| transposase 1310114007816 PE family; Region: PE; pfam00934 1310114007817 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007818 PPE family; Region: PPE; pfam00823 1310114007819 Integrase core domain; Region: rve; pfam00665 1310114007820 Integrase core domain; Region: rve_3; pfam13683 1310114007821 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114007822 MULE transposase domain; Region: MULE; pfam10551 1310114007823 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1310114007824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114007825 catalytic residue [active] 1310114007826 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1310114007827 putative ATP binding site [chemical binding]; other site 1310114007828 putative substrate binding site [chemical binding]; other site 1310114007829 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1310114007830 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1310114007831 active site 1310114007832 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1310114007833 dimer interface [polypeptide binding]; other site 1310114007834 active site 1310114007835 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1310114007836 dimer interface [polypeptide binding]; other site 1310114007837 active site 1310114007838 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1310114007839 potential frameshift: common BLAST hit: gi|471339506|ref|YP_007612219.1| phospho-sugar mutase 1310114007840 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1310114007841 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1310114007842 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1310114007843 23S rRNA interface [nucleotide binding]; other site 1310114007844 L3 interface [polypeptide binding]; other site 1310114007845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310114007846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310114007847 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1310114007848 potential frameshift: common BLAST hit: gi|397675401|ref|YP_006516936.1| ESX-4 secretion system protein eccC4 1310114007849 potential frameshift: common BLAST hit: gi|471339514|ref|YP_007612227.1| integral membrane protein 1310114007850 potential frameshift: common BLAST hit: gi|449065561|ref|YP_007432644.1| membrane-anchored mycosin mycP4 1310114007851 Protein of unknown function (DUF690); Region: DUF690; cl04939 1310114007852 Protein of unknown function (DUF690); Region: DUF690; cl04939 1310114007853 Cutinase; Region: Cutinase; pfam01083 1310114007854 Cutinase; Region: Cutinase; pfam01083 1310114007855 Cutinase; Region: Cutinase; pfam01083 1310114007856 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1310114007857 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1310114007858 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1310114007859 active site 1310114007860 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1310114007861 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1310114007862 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1310114007863 alphaNTD - beta interaction site [polypeptide binding]; other site 1310114007864 alphaNTD homodimer interface [polypeptide binding]; other site 1310114007865 alphaNTD - beta' interaction site [polypeptide binding]; other site 1310114007866 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1310114007867 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1310114007868 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1310114007869 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310114007870 RNA binding surface [nucleotide binding]; other site 1310114007871 30S ribosomal protein S11; Validated; Region: PRK05309 1310114007872 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1310114007873 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1310114007874 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1310114007875 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1310114007876 rRNA binding site [nucleotide binding]; other site 1310114007877 predicted 30S ribosome binding site; other site 1310114007878 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1310114007879 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1310114007880 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1310114007881 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1310114007882 NAD binding site [chemical binding]; other site 1310114007883 substrate binding site [chemical binding]; other site 1310114007884 homodimer interface [polypeptide binding]; other site 1310114007885 active site 1310114007886 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1310114007887 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310114007888 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310114007889 active site 1310114007890 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310114007891 extended (e) SDRs; Region: SDR_e; cd08946 1310114007892 NAD(P) binding site [chemical binding]; other site 1310114007893 active site 1310114007894 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1310114007895 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1310114007896 active site 1310114007897 catalytic residues [active] 1310114007898 metal binding site [ion binding]; metal-binding site 1310114007899 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1310114007900 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310114007901 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1310114007902 TPP-binding site [chemical binding]; other site 1310114007903 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1310114007904 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310114007905 PYR/PP interface [polypeptide binding]; other site 1310114007906 dimer interface [polypeptide binding]; other site 1310114007907 TPP binding site [chemical binding]; other site 1310114007908 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1310114007909 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1310114007910 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1310114007911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114007912 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310114007913 putative substrate translocation pore; other site 1310114007914 PE family; Region: PE; pfam00934 1310114007915 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114007916 PPE family; Region: PPE; pfam00823 1310114007917 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114007918 patatin-related protein; Region: TIGR03607 1310114007919 Patatin-like phospholipase; Region: Patatin; pfam01734 1310114007920 nucleophile elbow; other site 1310114007921 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1310114007922 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114007923 potential frameshift: common BLAST hit: gi|471339557|ref|YP_007612270.1| integral membrane protein 1310114007924 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1310114007925 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1310114007926 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1310114007927 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310114007928 short chain dehydrogenase; Provisional; Region: PRK05875 1310114007929 classical (c) SDRs; Region: SDR_c; cd05233 1310114007930 NAD(P) binding site [chemical binding]; other site 1310114007931 active site 1310114007932 Predicted membrane protein [Function unknown]; Region: COG2259 1310114007933 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310114007934 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1310114007935 Predicted transcriptional regulators [Transcription]; Region: COG1695 1310114007936 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1310114007937 potential frameshift: common BLAST hit: gi|397675444|ref|YP_006516979.1| trehalose-phosphate synthase 1310114007938 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114007939 mce related protein; Region: MCE; pfam02470 1310114007940 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114007941 mce related protein; Region: MCE; pfam02470 1310114007942 mce related protein; Region: MCE; pfam02470 1310114007943 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114007944 mce related protein; Region: MCE; pfam02470 1310114007945 potential frameshift: common BLAST hit: gi|471339576|ref|YP_007612289.1| MCE-family protein 1310114007946 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1310114007947 mce related protein; Region: MCE; pfam02470 1310114007948 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1310114007949 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310114007950 Permease; Region: Permease; pfam02405 1310114007951 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1310114007952 Permease; Region: Permease; pfam02405 1310114007953 potential frameshift: common BLAST hit: gi|471339580|ref|YP_007612293.1| 3-ketoacyl-(acyl-carrier-protein) reductase 1310114007954 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1310114007955 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1310114007956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114007957 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1310114007958 FAD binding site [chemical binding]; other site 1310114007959 substrate binding site [chemical binding]; other site 1310114007960 catalytic base [active] 1310114007961 potential frameshift: common BLAST hit: gi|433643697|ref|YP_007289456.1| Putative acyl-CoA dehydrogenase FadE27 1310114007962 acyl-CoA synthetase; Validated; Region: PRK07867 1310114007963 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1310114007964 acyl-activating enzyme (AAE) consensus motif; other site 1310114007965 putative AMP binding site [chemical binding]; other site 1310114007966 putative active site [active] 1310114007967 putative CoA binding site [chemical binding]; other site 1310114007968 PE family; Region: PE; pfam00934 1310114007969 PE family; Region: PE; pfam00934 1310114007970 potential frameshift: common BLAST hit: gi|433628651|ref|YP_007262280.1| Putative acetohydroxyacid synthase IlvX (acetolactate synthase) 1310114007971 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1310114007972 PE family; Region: PE; pfam00934 1310114007973 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114007974 CoA binding site [chemical binding]; other site 1310114007975 PE family; Region: PE; pfam00934 1310114007976 acyl-CoA synthetase; Validated; Region: PRK07798 1310114007977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114007978 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1310114007979 acyl-activating enzyme (AAE) consensus motif; other site 1310114007980 acyl-activating enzyme (AAE) consensus motif; other site 1310114007981 putative AMP binding site [chemical binding]; other site 1310114007982 putative active site [active] 1310114007983 putative CoA binding site [chemical binding]; other site 1310114007984 enoyl-CoA hydratase; Provisional; Region: PRK07799 1310114007985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114007986 substrate binding site [chemical binding]; other site 1310114007987 oxyanion hole (OAH) forming residues; other site 1310114007988 trimer interface [polypeptide binding]; other site 1310114007989 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114007990 Cytochrome P450; Region: p450; cl12078 1310114007991 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1310114007992 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310114007993 lipid-transfer protein; Provisional; Region: PRK07937 1310114007994 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310114007995 active site 1310114007996 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310114007997 active site 1310114007998 NHL repeat; Region: NHL; pfam01436 1310114007999 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1310114008000 NHL repeat; Region: NHL; pfam01436 1310114008001 NHL repeat; Region: NHL; pfam01436 1310114008002 NHL repeat; Region: NHL; pfam01436 1310114008003 NHL repeat; Region: NHL; pfam01436 1310114008004 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1310114008005 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1310114008006 trimer interface [polypeptide binding]; other site 1310114008007 putative metal binding site [ion binding]; other site 1310114008008 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1310114008009 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1310114008010 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1310114008011 short chain dehydrogenase; Provisional; Region: PRK07890 1310114008012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114008013 NAD(P) binding site [chemical binding]; other site 1310114008014 active site 1310114008015 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114008016 PPE family; Region: PPE; pfam00823 1310114008017 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114008018 potential frameshift: common BLAST hit: gi|449065646|ref|YP_007432729.1| PPE family protein 1310114008019 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1310114008020 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1310114008021 active site 1310114008022 catalytic residues [active] 1310114008023 metal binding site [ion binding]; metal-binding site 1310114008024 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1310114008025 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1310114008026 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1310114008027 potential frameshift: common BLAST hit: gi|471339617|ref|YP_007612330.1| hydratase 1310114008028 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1310114008029 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1310114008030 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1310114008031 enoyl-CoA hydratase; Region: PLN02864 1310114008032 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1310114008033 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1310114008034 dimer interaction site [polypeptide binding]; other site 1310114008035 substrate-binding tunnel; other site 1310114008036 active site 1310114008037 catalytic site [active] 1310114008038 substrate binding site [chemical binding]; other site 1310114008039 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114008040 PPE family; Region: PPE; pfam00823 1310114008041 PE-PPE domain; Region: PE-PPE; pfam08237 1310114008042 lipid-transfer protein; Provisional; Region: PRK07855 1310114008043 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1310114008044 active site 1310114008045 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1310114008046 putative active site [active] 1310114008047 putative catalytic site [active] 1310114008048 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1310114008049 active site 1310114008050 catalytic site [active] 1310114008051 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1310114008052 DUF35 OB-fold domain; Region: DUF35; pfam01796 1310114008053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114008054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114008055 active site 1310114008056 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114008057 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1310114008058 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114008059 active site 1310114008060 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114008061 Cytochrome P450; Region: p450; cl12078 1310114008062 potential frameshift: common BLAST hit: gi|471339627|ref|YP_007612340.1| acetyl-CoA acetyltransferase 1310114008063 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1310114008064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114008065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114008066 NAD(P) binding site [chemical binding]; other site 1310114008067 active site 1310114008068 short chain dehydrogenase; Provisional; Region: PRK07856 1310114008069 classical (c) SDRs; Region: SDR_c; cd05233 1310114008070 NAD(P) binding site [chemical binding]; other site 1310114008071 active site 1310114008072 potential frameshift: common BLAST hit: gi|471339631|ref|YP_007612344.1| enoyl-CoA hydratase 1310114008073 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1310114008074 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1310114008075 potential frameshift: common BLAST hit: gi|471339634|ref|YP_007612347.1| oxidoreductase 1310114008076 potential frameshift: common BLAST hit: gi|471339634|ref|YP_007612347.1| oxidoreductase 1310114008077 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1310114008078 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1310114008079 putative di-iron ligands [ion binding]; other site 1310114008080 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1310114008081 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1310114008082 FAD binding pocket [chemical binding]; other site 1310114008083 FAD binding motif [chemical binding]; other site 1310114008084 phosphate binding motif [ion binding]; other site 1310114008085 beta-alpha-beta structure motif; other site 1310114008086 NAD(p) ribose binding residues [chemical binding]; other site 1310114008087 NAD binding pocket [chemical binding]; other site 1310114008088 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1310114008089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310114008090 catalytic loop [active] 1310114008091 iron binding site [ion binding]; other site 1310114008092 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1310114008093 putative active site [active] 1310114008094 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310114008095 dimer interface [polypeptide binding]; other site 1310114008096 active site 1310114008097 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1310114008098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114008099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114008100 PPE family; Region: PPE; pfam00823 1310114008101 classical (c) SDRs; Region: SDR_c; cd05233 1310114008102 active site 1310114008103 classical (c) SDRs; Region: SDR_c; cd05233 1310114008104 potential frameshift: common BLAST hit: gi|471339641|ref|YP_007612354.1| acyl-CoA dehydrogenase 1310114008105 potential frameshift: common BLAST hit: gi|471339642|ref|YP_007612355.1| acyl-CoA synthetase 1310114008106 potential frameshift: common BLAST hit: gi|471339642|ref|YP_007612355.1| acyl-CoA synthetase 1310114008107 potential frameshift: common BLAST hit: gi|385996426|ref|YP_005914724.1| long-chain-fatty-acid-CoA ligase 1310114008108 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114008109 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114008110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114008111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114008112 active site 1310114008113 potential frameshift: common BLAST hit: gi|471339644|ref|YP_007612357.1| acyl-CoA dehydrogenase 1310114008114 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114008115 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1310114008116 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114008117 active site 1310114008118 potential frameshift: common BLAST hit: gi|449065678|ref|YP_007432761.1| aspartate aminotransferase 1310114008119 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1310114008120 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1310114008121 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1310114008122 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1310114008123 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1310114008124 active site 1310114008125 Fe binding site [ion binding]; other site 1310114008126 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1310114008127 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1310114008128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1310114008129 potential frameshift: common BLAST hit: gi|471339654|ref|YP_007612367.1| hemoglobine-like protein 1310114008130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310114008131 active site 1310114008132 potential frameshift: common BLAST hit: gi|471339656|ref|YP_007612369.1| acyl-CoA dehydrogenase 1310114008133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114008134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114008135 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310114008136 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1310114008137 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1310114008138 putative dimerization interface [polypeptide binding]; other site 1310114008139 putative ligand binding site [chemical binding]; other site 1310114008140 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310114008141 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1310114008142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1310114008143 potential frameshift: common BLAST hit: gi|449065692|ref|YP_007432775.1| arsenical PUMP integral membrane protein ArsB2 1310114008144 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310114008145 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1310114008146 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310114008147 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1310114008148 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310114008149 active site 1310114008150 HIGH motif; other site 1310114008151 nucleotide binding site [chemical binding]; other site 1310114008152 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1310114008153 KMSKS motif; other site 1310114008154 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1310114008155 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1310114008156 homotrimer interaction site [polypeptide binding]; other site 1310114008157 zinc binding site [ion binding]; other site 1310114008158 CDP-binding sites; other site 1310114008159 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1310114008160 substrate binding site; other site 1310114008161 dimer interface; other site 1310114008162 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1310114008163 potential frameshift: common BLAST hit: gi|449065699|ref|YP_007432782.1| DNA repair protein radA 1310114008164 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1310114008165 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1310114008166 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1310114008167 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1310114008168 active site clefts [active] 1310114008169 zinc binding site [ion binding]; other site 1310114008170 dimer interface [polypeptide binding]; other site 1310114008171 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1310114008172 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310114008173 minor groove reading motif; other site 1310114008174 helix-hairpin-helix signature motif; other site 1310114008175 substrate binding pocket [chemical binding]; other site 1310114008176 active site 1310114008177 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1310114008178 PE family; Region: PE; pfam00934 1310114008179 potential frameshift: common BLAST hit: gi|433643784|ref|YP_007289543.1| Conserved protein of unknown function TB11.2 1310114008180 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1310114008181 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1310114008182 Ami_2 domain; Region: Ami_2; smart00644 1310114008183 amidase catalytic site [active] 1310114008184 Zn binding residues [ion binding]; other site 1310114008185 substrate binding site [chemical binding]; other site 1310114008186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114008187 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1310114008188 Walker A motif; other site 1310114008189 ATP binding site [chemical binding]; other site 1310114008190 Walker B motif; other site 1310114008191 arginine finger; other site 1310114008192 UvrB/uvrC motif; Region: UVR; pfam02151 1310114008193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114008194 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1310114008195 Walker A motif; other site 1310114008196 ATP binding site [chemical binding]; other site 1310114008197 Walker B motif; other site 1310114008198 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1310114008199 Clp amino terminal domain; Region: Clp_N; pfam02861 1310114008200 Clp amino terminal domain; Region: Clp_N; pfam02861 1310114008201 Lsr2; Region: Lsr2; pfam11774 1310114008202 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1310114008203 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1310114008204 dimer interface [polypeptide binding]; other site 1310114008205 putative anticodon binding site; other site 1310114008206 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310114008207 motif 1; other site 1310114008208 dimer interface [polypeptide binding]; other site 1310114008209 active site 1310114008210 motif 2; other site 1310114008211 motif 3; other site 1310114008212 pantothenate kinase; Reviewed; Region: PRK13318 1310114008213 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1310114008214 tetramerization interface [polypeptide binding]; other site 1310114008215 active site 1310114008216 potential frameshift: common BLAST hit: gi|471339685|ref|YP_007612398.1| pantoate-beta-alanine ligase 1310114008217 Rossmann-like domain; Region: Rossmann-like; pfam10727 1310114008218 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1310114008219 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1310114008220 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1310114008221 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1310114008222 catalytic center binding site [active] 1310114008223 ATP binding site [chemical binding]; other site 1310114008224 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1310114008225 homooctamer interface [polypeptide binding]; other site 1310114008226 active site 1310114008227 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1310114008228 dihydropteroate synthase; Region: DHPS; TIGR01496 1310114008229 substrate binding pocket [chemical binding]; other site 1310114008230 dimer interface [polypeptide binding]; other site 1310114008231 inhibitor binding site; inhibition site 1310114008232 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1310114008233 homodecamer interface [polypeptide binding]; other site 1310114008234 GTP cyclohydrolase I; Provisional; Region: PLN03044 1310114008235 active site 1310114008236 putative catalytic site residues [active] 1310114008237 zinc binding site [ion binding]; other site 1310114008238 GTP-CH-I/GFRP interaction surface; other site 1310114008239 potential frameshift: common BLAST hit: gi|471339693|ref|YP_007612406.1| membrane-bound protease FTSH (cell divisionprotein) 1310114008240 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1310114008241 potential frameshift: common BLAST hit: gi|471339697|ref|YP_007612410.1| epoxide hydrolase 1310114008242 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310114008243 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1310114008244 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310114008245 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1310114008246 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1310114008247 PE family; Region: PE; pfam00934 1310114008248 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1310114008249 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1310114008250 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310114008251 active site 1310114008252 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1310114008253 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1310114008254 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1310114008255 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1310114008256 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1310114008257 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1310114008258 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1310114008259 dimer interface [polypeptide binding]; other site 1310114008260 substrate binding site [chemical binding]; other site 1310114008261 metal binding sites [ion binding]; metal-binding site 1310114008262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1310114008263 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1310114008264 Ligand binding site; other site 1310114008265 Putative Catalytic site; other site 1310114008266 DXD motif; other site 1310114008267 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1310114008268 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1310114008269 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310114008270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114008271 NAD(P) binding site [chemical binding]; other site 1310114008272 active site 1310114008273 potential frameshift: common BLAST hit: gi|471339715|ref|YP_007612428.1| transmembrane protein 1310114008274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1310114008275 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1310114008276 Integrase core domain; Region: rve; pfam00665 1310114008277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1310114008278 transposase; Provisional; Region: PRK06526 1310114008279 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1310114008280 Walker B motif; other site 1310114008281 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1310114008282 MULE transposase domain; Region: MULE; pfam10551 1310114008283 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1310114008284 Fic/DOC family; Region: Fic; cl00960 1310114008285 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1310114008286 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1310114008287 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1310114008288 potential frameshift: common BLAST hit: gi|433632734|ref|YP_007266362.1| Conserved membrane protein of unknown function 1310114008289 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1310114008290 domain II; other site 1310114008291 domain III; other site 1310114008292 nucleotide binding site [chemical binding]; other site 1310114008293 DNA binding groove [nucleotide binding] 1310114008294 catalytic site [active] 1310114008295 domain IV; other site 1310114008296 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1310114008297 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1310114008298 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1310114008299 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1310114008300 active site 1310114008301 interdomain interaction site; other site 1310114008302 putative metal-binding site [ion binding]; other site 1310114008303 nucleotide binding site [chemical binding]; other site 1310114008304 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1310114008305 domain I; other site 1310114008306 phosphate binding site [ion binding]; other site 1310114008307 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1310114008308 DNA-binding site [nucleotide binding]; DNA binding site 1310114008309 RNA-binding motif; other site 1310114008310 potential frameshift: common BLAST hit: gi|15843261|ref|NP_338298.1| DEAD/DEAH box helicase 1310114008311 PE family; Region: PE; pfam00934 1310114008312 PE family; Region: PE; pfam00934 1310114008313 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1310114008314 potential frameshift: common BLAST hit: gi|471339739|ref|YP_007612452.1| transmembrane protein 1310114008315 potential frameshift: common BLAST hit: gi|397675610|ref|YP_006517145.1| helicase/secretion ATPase 1310114008316 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1310114008317 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1310114008318 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310114008319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310114008320 motif II; other site 1310114008321 potential frameshift: common BLAST hit: gi|471339745|ref|YP_007612458.1| peptide ABC transporter ATP-binding protein 1310114008322 potential frameshift: common BLAST hit: gi|449065774|ref|YP_007432857.1| dipeptide-transport ATP-binding protein ABC transporter dppD 1310114008323 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1310114008324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114008325 ABC-ATPase subunit interface; other site 1310114008326 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1310114008327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114008328 dimer interface [polypeptide binding]; other site 1310114008329 conserved gate region; other site 1310114008330 ABC-ATPase subunit interface; other site 1310114008331 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1310114008332 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1310114008333 acetyl-CoA synthetase; Provisional; Region: PRK00174 1310114008334 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1310114008335 active site 1310114008336 CoA binding site [chemical binding]; other site 1310114008337 acyl-activating enzyme (AAE) consensus motif; other site 1310114008338 AMP binding site [chemical binding]; other site 1310114008339 acetate binding site [chemical binding]; other site 1310114008340 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1310114008341 potential frameshift: common BLAST hit: gi|471339752|ref|YP_007612465.1| epoxide hydrolase 1310114008342 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310114008343 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1310114008344 putative active site [active] 1310114008345 putative CoA binding site [chemical binding]; other site 1310114008346 nudix motif; other site 1310114008347 metal binding site [ion binding]; metal-binding site 1310114008348 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1310114008349 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1310114008350 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310114008351 minor groove reading motif; other site 1310114008352 helix-hairpin-helix signature motif; other site 1310114008353 substrate binding pocket [chemical binding]; other site 1310114008354 active site 1310114008355 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1310114008356 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310114008357 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310114008358 ligand binding site [chemical binding]; other site 1310114008359 flexible hinge region; other site 1310114008360 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1310114008361 putative switch regulator; other site 1310114008362 non-specific DNA interactions [nucleotide binding]; other site 1310114008363 DNA binding site [nucleotide binding] 1310114008364 sequence specific DNA binding site [nucleotide binding]; other site 1310114008365 putative cAMP binding site [chemical binding]; other site 1310114008366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310114008367 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1310114008368 homotrimer interaction site [polypeptide binding]; other site 1310114008369 putative active site [active] 1310114008370 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1310114008371 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1310114008372 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1310114008373 DTAP/Switch II; other site 1310114008374 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1310114008375 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1310114008376 DTAP/Switch II; other site 1310114008377 Switch I; other site 1310114008378 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1310114008379 Transcription factor WhiB; Region: Whib; pfam02467 1310114008380 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1310114008381 Transglycosylase; Region: Transgly; pfam00912 1310114008382 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1310114008383 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1310114008384 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1310114008385 phosphodiesterase YaeI; Provisional; Region: PRK11340 1310114008386 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1310114008387 putative active site [active] 1310114008388 putative metal binding site [ion binding]; other site 1310114008389 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1310114008390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114008391 catalytic residue [active] 1310114008392 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114008393 Cytochrome P450; Region: p450; cl12078 1310114008394 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310114008395 Cytochrome P450; Region: p450; cl12078 1310114008396 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1310114008397 anti sigma factor interaction site; other site 1310114008398 regulatory phosphorylation site [posttranslational modification]; other site 1310114008399 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1310114008400 potential frameshift: common BLAST hit: gi|433643878|ref|YP_007289637.1| Conserved membrane protein of unknown function 1310114008401 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1310114008402 MoxR-like ATPases [General function prediction only]; Region: COG0714 1310114008403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114008404 Walker A motif; other site 1310114008405 ATP binding site [chemical binding]; other site 1310114008406 Walker B motif; other site 1310114008407 arginine finger; other site 1310114008408 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1310114008409 Protein of unknown function DUF58; Region: DUF58; pfam01882 1310114008410 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1310114008411 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1310114008412 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1310114008413 glycerol kinase; Provisional; Region: glpK; PRK00047 1310114008414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310114008415 nucleotide binding site [chemical binding]; other site 1310114008416 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1310114008417 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1310114008418 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310114008419 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1310114008420 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1310114008421 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114008422 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1310114008423 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1310114008424 putative active site [active] 1310114008425 putative dimer interface [polypeptide binding]; other site 1310114008426 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 1310114008427 PknH-like extracellular domain; Region: PknH_C; pfam14032 1310114008428 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1310114008429 potential frameshift: common BLAST hit: gi|449065823|ref|YP_007432906.1| aspartate-semialdehyde dehydrogenase 1310114008430 aspartate kinase; Reviewed; Region: PRK06635 1310114008431 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1310114008432 putative nucleotide binding site [chemical binding]; other site 1310114008433 putative catalytic residues [active] 1310114008434 putative Mg ion binding site [ion binding]; other site 1310114008435 putative aspartate binding site [chemical binding]; other site 1310114008436 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1310114008437 putative allosteric regulatory site; other site 1310114008438 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1310114008439 putative allosteric regulatory residue; other site 1310114008440 2-isopropylmalate synthase; Validated; Region: PRK03739 1310114008441 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1310114008442 active site 1310114008443 catalytic residues [active] 1310114008444 metal binding site [ion binding]; metal-binding site 1310114008445 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1310114008446 potential frameshift: common BLAST hit: gi|385996567|ref|YP_005914865.1| DNA polymerase III subunit epsilon 1310114008447 potential frameshift: common BLAST hit: gi|471339799|ref|YP_007612512.1| probable ligase 1310114008448 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1310114008449 catalytic triad [active] 1310114008450 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1310114008451 putative active site [active] 1310114008452 recombination protein RecR; Reviewed; Region: recR; PRK00076 1310114008453 RecR protein; Region: RecR; pfam02132 1310114008454 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1310114008455 putative active site [active] 1310114008456 putative metal-binding site [ion binding]; other site 1310114008457 tetramer interface [polypeptide binding]; other site 1310114008458 hypothetical protein; Validated; Region: PRK00153 1310114008459 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1310114008460 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1310114008461 active site 1310114008462 metal binding site [ion binding]; metal-binding site 1310114008463 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1310114008464 hydrophobic ligand binding site; other site 1310114008465 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310114008466 FAD binding domain; Region: FAD_binding_4; pfam01565 1310114008467 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1310114008468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310114008469 S-adenosylmethionine binding site [chemical binding]; other site 1310114008470 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1310114008471 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1310114008472 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1310114008473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114008474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114008475 catalytic residue [active] 1310114008476 potential frameshift: common BLAST hit: gi|471339810|ref|YP_007612523.1| transmembrane protein 1310114008477 Cutinase; Region: Cutinase; pfam01083 1310114008478 Cutinase; Region: Cutinase; pfam01083 1310114008479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114008480 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1310114008481 NAD(P) binding site [chemical binding]; other site 1310114008482 active site 1310114008483 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114008484 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1310114008485 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1310114008486 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1310114008487 putative NAD(P) binding site [chemical binding]; other site 1310114008488 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1310114008489 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1310114008490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114008491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310114008492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310114008493 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310114008494 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310114008495 ligand binding site [chemical binding]; other site 1310114008496 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1310114008497 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1310114008498 active site 1310114008499 nucleophile elbow; other site 1310114008500 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1310114008501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310114008502 FeS/SAM binding site; other site 1310114008503 potential frameshift: common BLAST hit: gi|378773508|ref|YP_005173241.1| putative transferase 1310114008504 potential frameshift: common BLAST hit: gi|433643919|ref|YP_007289678.1| Putative transferase 1310114008505 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1310114008506 nucleotide binding site [chemical binding]; other site 1310114008507 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1310114008508 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1310114008509 active site 1310114008510 DNA binding site [nucleotide binding] 1310114008511 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1310114008512 DNA binding site [nucleotide binding] 1310114008513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1310114008514 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1310114008515 nudix motif; other site 1310114008516 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114008517 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114008518 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1310114008519 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1310114008520 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310114008521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310114008522 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1310114008523 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1310114008524 potential frameshift: common BLAST hit: gi|471339828|ref|YP_007612541.1| PPE family protein 1310114008525 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114008526 PPE family; Region: PPE; pfam00823 1310114008527 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1310114008528 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1310114008529 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114008530 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114008531 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1310114008532 potential frameshift: common BLAST hit: gi|471339834|ref|YP_007612547.1| cation transporter P-type ATPase J 1310114008533 potential frameshift: common BLAST hit: gi|339633734|ref|YP_004725376.1| ATPase P 1310114008534 potential frameshift: common BLAST hit: gi|339633734|ref|YP_004725376.1| ATPase P 1310114008535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310114008536 dimerization interface [polypeptide binding]; other site 1310114008537 putative DNA binding site [nucleotide binding]; other site 1310114008538 putative Zn2+ binding site [ion binding]; other site 1310114008539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 1310114008540 DNA binding domain, excisionase family; Region: excise; TIGR01764 1310114008541 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310114008542 active site 1310114008543 Int/Topo IB signature motif; other site 1310114008544 Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590 1310114008545 active site 1310114008546 Zn binding site [ion binding]; other site 1310114008547 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1310114008548 prephenate dehydrogenase; Validated; Region: PRK08507 1310114008549 prephenate dehydrogenase; Validated; Region: PRK06545 1310114008550 prephenate dehydrogenase; Validated; Region: PRK06545 1310114008551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1310114008552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310114008553 ABC-ATPase subunit interface; other site 1310114008554 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1310114008555 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1310114008556 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1310114008557 Walker A/P-loop; other site 1310114008558 ATP binding site [chemical binding]; other site 1310114008559 Q-loop/lid; other site 1310114008560 ABC transporter signature motif; other site 1310114008561 Walker B; other site 1310114008562 D-loop; other site 1310114008563 H-loop/switch region; other site 1310114008564 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1310114008565 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1310114008566 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1310114008567 putative active site [active] 1310114008568 putative substrate binding site [chemical binding]; other site 1310114008569 ATP binding site [chemical binding]; other site 1310114008570 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1310114008571 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310114008572 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1310114008573 potential frameshift: common BLAST hit: gi|471339856|ref|YP_007612569.1| two component sensor kinase 1310114008574 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310114008575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310114008576 active site 1310114008577 phosphorylation site [posttranslational modification] 1310114008578 intermolecular recognition site; other site 1310114008579 dimerization interface [polypeptide binding]; other site 1310114008580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310114008581 DNA binding site [nucleotide binding] 1310114008582 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 1310114008583 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114008584 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114008585 SnoaL-like domain; Region: SnoaL_2; pfam12680 1310114008586 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310114008587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310114008588 homodimer interface [polypeptide binding]; other site 1310114008589 catalytic residue [active] 1310114008590 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1310114008591 TIGR03086 family protein; Region: TIGR03086 1310114008592 enoyl-CoA hydratase; Provisional; Region: PRK06142 1310114008593 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310114008594 substrate binding site [chemical binding]; other site 1310114008595 oxyanion hole (OAH) forming residues; other site 1310114008596 trimer interface [polypeptide binding]; other site 1310114008597 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114008598 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114008599 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310114008600 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310114008601 potential protein location (hypothetical protein J113_26365 [Mycobacterium tuberculosis CAS/NITR204]) that overlaps RNA (tRNA-S) 1310114008602 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114008603 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310114008604 NAD(P) binding site [chemical binding]; other site 1310114008605 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1310114008606 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310114008607 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310114008608 catalytic residue [active] 1310114008609 potential frameshift: common BLAST hit: gi|471339873|ref|YP_007612586.1| transmembrane protein 1310114008610 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1310114008611 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1310114008612 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1310114008613 Walker A/P-loop; other site 1310114008614 ATP binding site [chemical binding]; other site 1310114008615 Q-loop/lid; other site 1310114008616 ABC transporter signature motif; other site 1310114008617 Walker B; other site 1310114008618 D-loop; other site 1310114008619 H-loop/switch region; other site 1310114008620 potential frameshift: common BLAST hit: gi|471339876|ref|YP_007612589.1| L-rhamnosyltransferase 1310114008621 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1310114008622 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1310114008623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114008624 NAD(P) binding site [chemical binding]; other site 1310114008625 active site 1310114008626 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310114008627 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310114008628 active site 1310114008629 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1310114008630 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1310114008631 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1310114008632 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1310114008633 Predicted membrane protein [Function unknown]; Region: COG2246 1310114008634 GtrA-like protein; Region: GtrA; pfam04138 1310114008635 potential frameshift: common BLAST hit: gi|15843412|ref|NP_338449.1| oxidoreductase, FAD-binding 1310114008636 short chain dehydrogenase; Provisional; Region: PRK07904 1310114008637 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310114008638 NAD(P) binding site [chemical binding]; other site 1310114008639 active site 1310114008640 potential frameshift: common BLAST hit: gi|449065909|ref|YP_007432992.1| conserved transmembrane protein 1310114008641 potential frameshift: common BLAST hit: gi|433636893|ref|YP_007270520.1| Conserved membrane protein of unknown function 1310114008642 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1310114008643 potential frameshift: common BLAST hit: gi|397675754|ref|YP_006517290.1| arabinosyltransferase C 1310114008644 potential frameshift: common BLAST hit: gi|397675754|ref|YP_006517290.1| arabinosyltransferase C 1310114008645 potential frameshift: common BLAST hit: gi|471339888|ref|YP_007612601.1| integral membrane indolylacetylinositolarabinosyltransferase 1310114008646 potential frameshift: common BLAST hit: gi|471339888|ref|YP_007612601.1| integral membrane indolylacetylinositolarabinosyltransferase 1310114008647 potential frameshift: common BLAST hit: gi|471339888|ref|YP_007612601.1| integral membrane indolylacetylinositolarabinosyltransferase 1310114008648 potential frameshift: common BLAST hit: gi|471339888|ref|YP_007612601.1| integral membrane indolylacetylinositolarabinosyltransferase 1310114008649 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1310114008650 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1310114008651 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1310114008652 potential frameshift: common BLAST hit: gi|471339891|ref|YP_007612604.1| acyl-CoA dehydrogenase 1310114008653 potential frameshift: common BLAST hit: gi|433628941|ref|YP_007262570.1| Putative acyl-CoA dehydrogenase FadE35 1310114008654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310114008655 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310114008656 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310114008657 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310114008658 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310114008659 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1310114008660 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310114008661 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310114008662 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310114008663 potential frameshift: common BLAST hit: gi|471339894|ref|YP_007612607.1| polyketide synthase 1310114008664 potential frameshift: common BLAST hit: gi|471339894|ref|YP_007612607.1| polyketide synthase 1310114008665 potential frameshift: common BLAST hit: gi|397675762|ref|YP_006517298.1| fatty acid CoA ligase FadD32 1310114008666 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310114008667 acyl-activating enzyme (AAE) consensus motif; other site 1310114008668 CoA binding site [chemical binding]; other site 1310114008669 Cutinase; Region: Cutinase; pfam01083 1310114008670 potential frameshift: common BLAST hit: gi|471339897|ref|YP_007612610.1| secreted MPT51/MPB51 antigen protein 1310114008671 Putative esterase; Region: Esterase; pfam00756 1310114008672 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1310114008673 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1310114008674 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310114008675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310114008676 active site 1310114008677 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1310114008678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310114008679 UDP-galactopyranose mutase; Region: GLF; pfam03275 1310114008680 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1310114008681 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1310114008682 amidase catalytic site [active] 1310114008683 Zn binding residues [ion binding]; other site 1310114008684 substrate binding site [chemical binding]; other site 1310114008685 LGFP repeat; Region: LGFP; pfam08310 1310114008686 PE family; Region: PE; pfam00934 1310114008687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310114008688 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1310114008689 active site 1310114008690 motif I; other site 1310114008691 motif II; other site 1310114008692 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1310114008693 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114008694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310114008695 putative acyl-acceptor binding pocket; other site 1310114008696 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114008697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310114008698 putative acyl-acceptor binding pocket; other site 1310114008699 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310114008700 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310114008701 putative acyl-acceptor binding pocket; other site 1310114008702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1310114008703 Phosphotransferase enzyme family; Region: APH; pfam01636 1310114008704 active site 1310114008705 ATP binding site [chemical binding]; other site 1310114008706 substrate binding site [chemical binding]; other site 1310114008707 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1310114008708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1310114008709 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1310114008710 iron-sulfur cluster [ion binding]; other site 1310114008711 [2Fe-2S] cluster binding site [ion binding]; other site 1310114008712 Condensation domain; Region: Condensation; pfam00668 1310114008713 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1310114008714 PE-PPE domain; Region: PE-PPE; pfam08237 1310114008715 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310114008716 Condensation domain; Region: Condensation; pfam00668 1310114008717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310114008718 KR domain; Region: KR; pfam08659 1310114008719 active site 1310114008720 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310114008721 potential frameshift: common BLAST hit: gi|397675786|ref|YP_006517322.1| phthioceranic/hydroxyphthioceranic acid synthase 1310114008722 acyl-CoA synthetase; Validated; Region: PRK05850 1310114008723 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310114008724 acyl-activating enzyme (AAE) consensus motif; other site 1310114008725 active site 1310114008726 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1310114008727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1310114008728 Probable transposase; Region: OrfB_IS605; pfam01385 1310114008729 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1310114008730 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1310114008731 catalytic residues [active] 1310114008732 catalytic nucleophile [active] 1310114008733 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1310114008734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310114008735 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1310114008736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114008737 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1310114008738 Cupin domain; Region: Cupin_2; cl17218 1310114008739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310114008740 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310114008741 seryl-tRNA synthetase; Provisional; Region: PRK05431 1310114008742 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1310114008743 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1310114008744 dimer interface [polypeptide binding]; other site 1310114008745 active site 1310114008746 motif 1; other site 1310114008747 motif 2; other site 1310114008748 motif 3; other site 1310114008749 Septum formation; Region: Septum_form; pfam13845 1310114008750 Septum formation; Region: Septum_form; pfam13845 1310114008751 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1310114008752 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1310114008753 Prephenate dehydratase; Region: PDT; pfam00800 1310114008754 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1310114008755 putative L-Phe binding site [chemical binding]; other site 1310114008756 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1310114008757 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1310114008758 Ferritin-like domain; Region: Ferritin; pfam00210 1310114008759 ferroxidase diiron center [ion binding]; other site 1310114008760 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1310114008761 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1310114008762 putative active site [active] 1310114008763 catalytic site [active] 1310114008764 putative metal binding site [ion binding]; other site 1310114008765 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1310114008766 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310114008767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310114008768 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1310114008769 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1310114008770 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1310114008771 Predicted membrane protein [Function unknown]; Region: COG2119 1310114008772 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1310114008773 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1310114008774 Fimbrial protein; Region: Fimbrial; cl01416 1310114008775 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1310114008776 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310114008777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310114008778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310114008779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310114008780 hypothetical protein; Provisional; Region: PRK07945 1310114008781 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1310114008782 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1310114008783 active site 1310114008784 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1310114008785 potential frameshift: common BLAST hit: gi|471339961|ref|YP_007612674.1| ferredoxin-dependent glutamate synthase [NADPH]large subunit 1310114008786 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310114008787 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310114008788 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1310114008789 EspG family; Region: ESX-1_EspG; pfam14011 1310114008790 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310114008791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114008792 Walker A motif; other site 1310114008793 ATP binding site [chemical binding]; other site 1310114008794 Walker B motif; other site 1310114008795 arginine finger; other site 1310114008796 potential frameshift: common BLAST hit: gi|397675833|ref|YP_006517369.1| ESX-1 secretion system protein eccB1 1310114008797 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310114008798 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310114008799 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1310114008800 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310114008801 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310114008802 PE family; Region: PE; pfam00934 1310114008803 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1310114008804 PPE family; Region: PPE; pfam00823 1310114008805 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1310114008806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310114008807 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310114008808 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1310114008809 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1310114008810 potential frameshift: common BLAST hit: gi|433629028|ref|YP_007262657.1| ESX conserved componant EccE1 1310114008811 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1310114008812 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1310114008813 active site 1310114008814 catalytic residues [active] 1310114008815 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1310114008816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310114008817 Walker A motif; other site 1310114008818 ATP binding site [chemical binding]; other site 1310114008819 Walker B motif; other site 1310114008820 arginine finger; other site 1310114008821 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1310114008822 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310114008823 catalytic residues [active] 1310114008824 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1310114008825 active site 1310114008826 catalytic residues [active] 1310114008827 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1310114008828 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1310114008829 potential frameshift: common BLAST hit: gi|433629035|ref|YP_007262664.1| Putative ESX-2 secretion-associated protein EspG2 1310114008830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310114008831 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1310114008832 PPE family; Region: PPE; pfam00823 1310114008833 potential frameshift: common BLAST hit: gi|397675858|ref|YP_006517394.1| type VII secretion protein EccCa 1310114008834 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310114008835 potential frameshift: common BLAST hit: gi|397675859|ref|YP_006517395.1| ESX-2 secretion system protein eccB2 1310114008836 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1310114008837 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1310114008838 catalytic residue [active] 1310114008839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310114008840 potential frameshift: common BLAST hit: gi|471340014|ref|YP_007612727.1| poly(A) polymerase 1310114008841 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1310114008842 nudix motif; other site 1310114008843 active site 1310114008844 metal binding site [ion binding]; metal-binding site 1310114008845 Ap6A binding site [chemical binding]; other site 1310114008846 potential frameshift: common BLAST hit: gi|397675875|ref|YP_006517411.1| integral membrane protein MviN 1310114008847 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1310114008848 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1310114008849 potential frameshift: common BLAST hit: gi|449066034|ref|YP_007433117.1| putative alanine rich protein 1310114008850 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1310114008851 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310114008852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310114008853 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310114008854 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310114008855 catalytic residues [active] 1310114008856 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1310114008857 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1310114008858 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1310114008859 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1310114008860 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1310114008861 active site 1310114008862 metal binding site [ion binding]; metal-binding site 1310114008863 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1310114008864 ParB-like nuclease domain; Region: ParB; smart00470 1310114008865 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1310114008866 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310114008867 P-loop; other site 1310114008868 Magnesium ion binding site [ion binding]; other site 1310114008869 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310114008870 Magnesium ion binding site [ion binding]; other site 1310114008871 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1310114008872 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1310114008873 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1310114008874 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1310114008875 G-X-X-G motif; other site 1310114008876 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1310114008877 RxxxH motif; other site 1310114008878 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1310114008879 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1310114008880 Ribonuclease P; Region: Ribonuclease_P; cl00457 1310114008881 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399